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1 544( 56 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec * *

2 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 57 ) % Escherichia coli Pseudomonas aeruginosa Enterococcus faecalis E. coli P. aeruginosa E. faecalis E. coli 40% E. coli E. coli P. aeruginosa E. faecalis P. aeruginosa E. coli P. aeruginosa E. faecalis

3 546( 58 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. 1 23) I. 1. Fig % (236/565) 58.2% (329/565) % (30/236) 26.7% (8/30) 60.0% (18/30) 13.3% (4/30) % (84/236) % (158/329) % 2. Fig. 2 Escherichia coli 51.7% 23.5% 13.6% Pseudomonas aeruginosa 2.9% 7.9% 13.6% Enterococcus faecalis 8.8% 12.6% 21.5% 3. Fig. 3 Fig. 3 1 E. coli %, % %, % E. faecalis %, %, %, % Fig. 3 2 E. coli %, %, %, % E. faecalis %, %, %, % E. coli P. aeruginosa Fig E. faecalis %, % E. coli, P. aeruginosa, S. aureus

4 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 59 ) Fig

5 548( 60 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. Fig

6 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 61 ) Fig

7 550( 62 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec Fig E. coli 50.3%54.0% P. aeruginosa 2.0% 4.6% E. faecalis 9.2% 8.0% E. coli E. faecalis 25.7%, 12.4% 13.2% E. coli P. aeruginosa S. aureus 6.4%, 6.4% 15.1%, 7.5% P. aeruginosa 10.3% 18.6% E. coli S. aureus 16.8%, 11.2%, 8.6%, 7.1% E. faecalis 20.6% 22.9% 5. Fig E. coli E. faecalis 33.3% 14.8% E. coli 57.0% 6 Klebsiella spp., Proteus spp., Enterobacter spp., P. aeruginosa, S. aureus, E. faecalis E. coli, E. faecalis, P. aeruginosa 22.3%, 13.9%, 11.4% E. coli, E. faecalis, S. aureus 25.0%, 11.0%, 7.4% E. faecalis 25.0% P. aeruginosa 14.5% E. coli 17.0% E. faecalis 13.2% II. 1 23) %, % E. coli

8 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 63 ) Fig

9 552( 64 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. Fig

10 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 65 ) P. aeruginosa E. faecalis P. aeruginosa E. coli % E. faecalis E. coli E. faecalis E. coli P. aeruginosa E. faecalis E. faecalis 55.6% E. coli P. aeruginosa E. coli P. aeruginosa E. coli Klebsiella spp., P. aeruginosa, E. faecalis E. coli, E. faecalis P. aeruginosa E. coli, E. faecalis E. coli P. aeruginosa P. aeruginosa E. faecalis E. coli, P. aeruginosa, E. faecalis 1) E.coli, Klebsiella, Citrobacter Proteus Jpn. J. Antibiotics 34: , ) Escherichia coli, Klebsiella, Citrobacter Proteus Jpn. J. Antibiotics 36: , ) Jpn. J. Antibiotics 37: , ) Jpn. J. Antibiotics 38: , ) Jpn. J. Antibiotics 39: , ) Jpn. J. Antibiotics 40: , ) Jpn. J. Antibiotics 42: , ) Jpn. J. Antibiotics 43: , ) Jpn. J. Antibiotics 45: , ) Jpn. J. Antibiotics 48: , ) Jpn. J. Antibiotics 48: , ) Jpn. J. Antibiotics

11 554( 66 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. 48: , ) Jpn. J. Antibiotics 48: , ) Jpn. J. Antibiotics 48: , ) Jpn. J. Antibiotics 49: , ) Jpn. J. Antibiotics 50: , ) Jpn. J. Antibiotics 51: , ) Jpn. J. Antibiotics 52: , ) Jpn. J. Antibiotics 53: , ) Jpn. J. Antibiotics 54: , ) Jpn. J. Antibiotics 55: , ) Jpn. J. Antibiotics 56: , ) Jpn. J. Antibiotics 57: , 2004 COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM PATIENTS WITH URINARY TRACT INFECTIONS (2003) II. BACKGROUND OF PATIENTS YOSHIAKI KUMAMOTO*, TAIJI TSUKAMOTO, MASANORI MATSUKAWA and YASUHARU KUNISHIMA Department of Urology, Sapporo Medical University School of Medicine (*: a honorary professor at present) TAKAOKI HIROSE Department of Urology, Hokkaido Social Insurance Hospital OSAMU YAMAGUTI and KEI ISHIBASHI Department of Urology, Fukushima Medical University TATSUO SUZUTANI Department of Microbiology, Fukushima Medical University SHIRO SHIGETA Division, Bureau of Hospital Administration, Fukushima Prefectural Goverment HIROSHI YOSHIDA and YUUJI IMAFUKU Department of Clinical Laboratory Medicine, Fukushima Medical University

12 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 67 ) MASARU MURAI Department of Urology, Keio University School of Medicine KIYOAKI WATANABE, YOSHIO KOBAYASHI and HIROSHI UCHIDA Central Clinical Laboratories, Keio University School of Medicine SEIJI MATSUDA Department of Gynecology, Koto Hospital SHINICHI SATO Department of Clinical Laboratories, Koto Hospital TOSHITSUGU OKA and MASAYA KITAMURA Department of Urology Osaka National Hospital YOSHINORI FUKUHARA Department of Clinical Laboratories, Osaka National Hospital SADAO KAMIDONO Division of Urology, Kobe University Graduate School of Medicine SOICHI ARAKAWA Department of Surgical Operation, Kobe University Hospital MAKOTO FUJIME and KAZUHIKO FUJITA Department of Urology, Juntendo University School of Medicine HIROMI KUMON and KOICHI MONDEN Department of Urology, Okayama University Graduate School of Medicine and Dentistry JUN IGARI Urayasu Hospital, Juntendo University School of Medicine TOYOKO OGURI Department of Clinical Laboratories, Juntendo University Hospital KEIZO YAMAGUCHI and NOBUHIKO FURUYA Department of Microbiology, Toho University School of Medicine TAKASHI DEGUCHI and SATOSHI ISHIHARA Urological Devision, Disease Control Course, Gifu University Graduate School of Medicine HIROSHI OOE Department of Urology, Kyoto Second Red Cross Hospital TETSURO MATSUMOTO and KOICHI TAKAHASHI Department of Urology, School of Medicine, University of Occupational and Environmental Health SEIJI NAITO, TOSHIHISA EGASHIRA, and TAKATOSHI KONISHI Department of Urology, Kyushu University Graduate School of Medicine SHIGERU KOHNO Second Department of Internal Medicine, Nagasaki University School of Medicine YOICHI HIRAKATA, AKIRA KONDO, JUNICHI MATSUDA and MICHIKO NAKANO Department of Laboratory Medicine, Nagasaki University Hospital of Medicine and Dentistry MINEKO NISHIKAWA Department of Clinical Laboratory, Kyoto Second Red Cross Hospital YUMIKO SUZUKI Department of Laboratory, Yamada Evidence Research

13 556( 68 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. Seven hundred and nineteen bacterial strains isolated from 565 patients diagnosed as having urinary tract infections (UTIs) in 14 institutions in Japan were collected between August 2002 and July The frequency of bacteria isolation divided with patient clinical background was compared. The clinical background investigated included sex, age, type of infections, timing of antibiotics administration, and presence or absence of surgery affecting a decrease in defense against infection. The bacterial strains were divided with the age and sex of the patients and the types of infections. In males, the number of patients aged less than 50 years was few and the complicated UTIs without indwelling catheter was observed most frequently. Number of patients aged years was greater in female than male. In all of ages except 0 9 and years, the ratio of the uncomplicated UTIs was high, accounting for % of all types of infections. In the present time, the bacteria most frequently isolated were Escherichia coli, Pseudomonas aeruginosa and Enterococcus faecalis also were relatively frequently isolated. E. coli was most frequently isolated from the uncomplicated UTIs, and P. aeruginosa and E. faecalis were frequently isolated from the complicated UTIs with indwelling catheter. With respect to the relation of these results to the age of the patients, in the uncomplicated UTIs, the isolation frequency of E. coli was the highest in all age groups, accounting for 40% or higher. In the complicated UTIs without indwelling catheter, the isolation frequency of E. coli decreased with aging of the patients but still was the highest in all age groups. In the complicated UTIs with indwelling catheter, the isolation frequency of E. coli was lower than in the uncomplicated UTIs in all age groups and P. aeruginosa and E. faecalis were more frequently isolated. In comparison of causative bacteria in UTIs between before and after the administration of antibiotics, P. aeruginosa increased after the administration in any types of UTIs. In comparison of causative bacteria in UTIs with or without surgery, E. coli was more frequently isolated in the patients without surgery, while P. aeruginosa and E. faecalis were more frequently isolated in the patients with surgery in any UTIs.

03-b-„FŒ{›xŒ¾-4.02

03-b-„FŒ{›xŒ¾-4.02 518( 30 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. 25 2003 1. * * Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 519( 31 ) 9 5 2003 8 2004 7 14 565 701 258 (36.8%) 443 (63.2%) Staphylococcus aureus

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