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1

2 IPO FDA

3 CEO CSO Scientific Advisory Board IPO M&A /3 IPO IPO M&A IPO ,457 2

4 342 ExitIPO M&A 20 R&D 3

5 NIH VC Scientific Advisory Board 7. CRO NASDAQ 10. FDA M&A IPO

6 , , IT IT % 5

7

8 The Global Biotechnology Report 2002, ERNST & YOUNG 6 6 7

9 TLO CEO CEO CSO Scientific Advisory Board IT 7 2 The Global Biotechnology Report 2002, ERNST & YOUNG ,

10 , FDA ,000-3, , , JETRO FDA 3 FDA FDA ,000 FDA 1 1 9

11 FDA FDA FDA CT

12 , / /3 4 IT FDA IPO IPO IPO Biotechnology Industry Organization , ,000 11

13 VC IPO IPO VC IPO VC VC VC IT VC 12 VC 6 Money Tree Survey, PricewaterhouseCoopers VC 12 VC

14 IPO IPO M&A IPO ES , ,210 2 ES ES M&A R&D VC 13

15 Onyx Pharmaceuticals ONYX ONXX/ Bayer BAY BAY Raf Geron GERN/ Applied Biosystems NY ABI/ 4000 Maxygen 1030 MAXY/ 80 CuraGen CRGN/ 4 OSI Pharmaceuticals 8 40 OSIP/ IntraBiotics IBPI/ Iseganan hydrochloride 3 Cell Pathways Aptosyn CP461 CLPA/ Bio Business News VC IT 14

16 + NIH The Global Biotechnology Report 2002, ERNST & YOUNG UCSF 15

17 UCB 1976 EX- OB IT IT IT 16

18 UCSD UCSD Eli Lilly & Co. IDECGen-ProbeProgenix IDECGeneSys TherapeuticsCorixa IDEC EX- UCSD CONNECT UCSD

19 MG 18

20 VC IPO FDA 9 18 Phase Phase Phase VC MG 18 IPO 19

21 97 21 NIH NIH 1998 NIH , , NIH Research Grant 2001, JETRO NIH NIH NIH NIH NIH 20

22 10 NIH NIH NIH 1 NIH DC NIH SBIRSmall Business Innovation Research 19 SBIR 500 SBIR NIH , ,340 1 SBIR VC VC Challenge Investment Program Enterprise Investment Fund STAR Bio Star Project 20 SBIR 13 FDA SBIR SBIR FDA

23 22 23 TLO TLO TLO 15 1/3 1/3 11 TLO TLO Genetics Institute EPO Genetics Institute 22

24 NIH 1980 TLO 10 TLO TLO 10 TLO (1) 24 (2) (3) Licensing Officer (4) (5) (6) TLO CEO VC TLO UCSD TLO exclusive non-exclusive 27 23

25 Report on California s Biomedical R&D Industry, California Healthcare Institute The Scripps Research Institute The Salk Institute 24

26 29 30 VC VC VC VC VC 29 Conflict of Interest 30 Conflict of Commitment 25

27 CEO CEO VC VC VC IPO M&A IPO M&A 1 Scientific Advisory Board 1 25 VC UCSF DNA 26

28 The Global Biotechnology Report 2002, ERNST & YOUNG The Global Biotechnology Report 2002, ERNST & YOUNG 27

29 VC VC VC 1 VC VC Scientific Advisor Scientific Advisor VC ,000 Scientific Advisor 28

30 31 VC VC VC VC VC VC VC CEO CEO CSO VC VC Preferred Stock 32 VC 270 CEO VC VC NPV 32 Common Stock Preferred Stock 2 VC 29

31 VC A B C B C A VC VC VC VC IPO M&A VC IPO M&A IPO VC VC VC 3 VC

32 VC The Global Biotechnology Report 2002, ERNST & YOUNG 33 VC VC VC 34 VC VC Ph.D. M.D. MBA VC 33 A VC VC (Limited Partnership) VC General Partner VC VC 31

33 VC 10 VC VC VC VC VC Money Tree Survey, PricewaterhouseCoopers 27 CEO VC 32

34 VC CEO CEO CSO CEO VC VC CEO CSO Scientific Advisory BoardSAB VC CEO MBA CEO CEO VC B 100 CEO CFO CEO CSO CSO 10 IPO CEO CEO FDA Scientific Advisory BoardSAB 46 SAB CEO CSO SAB VC CEO SAB SAB SAB 33

35 SAB SAB SAB SAB SAB SAB CROContract Research Organization CRO CRO CRO FDA CRO 1970 CRO 1980 CRO CRO CRO 500 CRO CRO CRO CRO CRO CRO 34

36 CRO CRO 50 CRO CRO CRO 35 17CRO % 58% MG CRO CRO CRO CRO 35 CRO 1997 Good Clinical Practice CRO CRO 50 MG HP 35

37 CRO Catalyst Pharmaceutical Research LLC, Dr. Richard AnthonyCEO Alpha Therapeutic Corporationwww.alphather.com 1998 CRO Catalyst Pharmaceutical Research LLC 2003 JETRO 36

38 FDA The Global Biotechnology Report 2002, ERNST & YOUNG 37

39 VC 39 IDEC 20 IDEC Rituxan IDEC IDEC 38

40 1 M&A M&A M&A M&A IPO M&A M&A , NASDAQ IPO 1 VC IPO IPO IPO 2 2 1, VC 39

41 IPO VC 20NASDAQ ,800 7,500 7,500 7, ,800 2,000, NTT IPO IPO IPO VC IPO VC IPO

42 FDA IPO 1 FDA IPO IPO IPO 21FDA Biotechnology Industry Organization FDA FDA FDA Jane E. Henney FDA Mark B. McClellan FDA McClellan 41

43 FDA , M&A 42

44 20 4,016 1,120 7, Annual Report 1980 UCLA

45 IPO FDA FDA Applied Molecular Genetics EPOGEN 1989 EPOGEN 1991 NEUPOGEN INFERGEN 2001 ARANESP KINERET 2002 NEULASTA Immunex

46 , FDA Yahoo Finance MA Novantrone Leukine 45

47 46

48 MEDICINOVA CEO 1989 MIT Sloan School MIT CEO IPO , MN-001 Store-Operated Calcium Channel Modulators Vascular Targeting Agents ( Angiogene ) Pharmaceuticals (UK) Ltd CRO FDA

49 26 JAFCO Avigen CEO USA Kenneth W. Locke, Ph.D. USA Hoechst 27 Scientific Advisory Board Ronald A. Simon, M.D Adjunct Professor, Dept. of Molecular & Experimental Medicine, The Scripps Research Institute Carl F. Ware, Ph.D. La Jolla Institute of Allergy and Immunology Adjunct Professor of Biology, University of California, San Diego Director JAFCO Avigen IPO M&A IPO IPO IPO

50 U U U OB MBA VC 49

51 MEDICINOVA, CEO 47 Maximize MIT Sloan School 91 MBA MIT MIT MBA USA CEO

52 ExitIPO M&A 20 R&D 51

53 University of Southern California, School of Medicine MediciNova, Inc. President and CEO ProSpine, Inc. President and CEO JAFCO Life Science Investment Officer Bio-Xcelerator K.K. President and CSO Catalyst Pharmaceutical Research LLC Dr. Richard AnthonyPresident and CEO, University of Southern California, Keck School of Medicine Mr. Pablo ValenciaDirector University of California, San Diego, Technology Transfer Office Dr. Alan S. PaauDirector University of California, San Diego, CONNECT Ms. Carolyn LeeDirector, Mr. Bob BensonManager IDEC Pharmaceuticals Co. Dr. Roland A. NewmanSenior Director, Business Development, Mr. Vince ReadonDirector, Corporate Communications Stanford University, Office of Technology Licensing Mr. Jon SandelinSenior Associate, Ms. Sally O NeilManager, Industrial Contracts Catellus Urban Development Corporation Mr. Michael W. MonroeSenior VP The Global Biotechnology Report 2002, ERNST & YOUNG Money Tree SurveyPricewaterhouseCoopers Amgen Annual Report UC Technology Transfer Annual Report 2001 (University of California, Office of Technology Transfer) AUTM Licensing Survey FY2000 (Association of University Technology Managers, Inc.) Editors and Reporters Guide to Biotechnology (Biotechnology Industry Organization) 2002 Report on California s Biomedical R&D Industry California Healthcare Institute,,,,H&I DNA, 52

54 21,SCI, 2001, NTT, , , (JETRO, ) 3 ) 1 JETRO, , , Biotechnology Industry Organization ( PricewaterhouseCoopershttp:// NASDAQ Yahoo Finance Bio Business News Amgen Inc. MediciNova, Inc. Catalyst Pharmaceutical Research LLC University of California, Office of Technology Transfer ( University of California, San Diego, CONNECT ( 53

IP Management Within Universities: Experiences in the US

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