平成15 年度 大気汚染と花粉症の相互作用に関する調査研究(疫学研究)研究報告書

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1 MEDLINE (1) ) ,108 50, %

2 5.2% ) ,471 4, % 17,301 8,527 8, % 17.3% % 19.8% 60 Okuda ) 10, , , % 3, , , % %

3 19.4% 100% 12.2% %54.1% 82% ) 3) population study ) D (Definite) P (Possible) N (Negative) 2 1 D D P % %1998 D 27.2% P 30.1% N 37.6% % 29.2% 34.7% U ,7) ,123

4 , % 6, % 4 2, % 31.3% 28.9% 37.8% 36.8% 1, % % 23.1% 22.4% 29.0% 26.5% EC PM2.5 SPM 3 EC PM2.5 SPM NOx 2 3 (2) IgE Ozasa ) % IgE IgE 1.5 IU/ml % 1.5 IU/ml % 15.0 IU/ml % <0.35, , IU/ml

5 Okawa ) , IgE , 2000, IgE IgE IgE 60 IgE IgE CAP RAST % IgE IgE (3) ,7) PM PM2.5 SPM TSP PM2.5 SPM TSP EC PM2.5 SPM TSP EC

6 Nakamura ) 408 1) 2) ±45.5± ±17.3 IgE eosinophil peroxidase (EPO) interleukin-4 recepter α-chain (IL4RA) 206 IgE 75 EPO Pro358Leu IL4RA Ile50Val Glu357Ala EPO Pro358Leu IgE IL4RA Ile50Val Glu357Ala IgE IgE 10 EPO Pro358Leu IL4RA Ile50Val Glu357Ala Ile50Val Glu357Ala EPO IL4RA EPO Pro358Leu (4) )

7 r = 0.383, r = r = % 1 (5) QOL (Quality of life) ) IgE QOL (Quality of life) 15 4 QOL IgE 271 QOL IgE QOL ) QOL health related QOL: HRQOL 2 Juniper rhinoconjunctivitis quality of life questionnaire: RQLQ SF

8 SF-36 QOL 8 QOL QOL QOL ) Juniper rhinoconjunctivitis quality of life questionnaire: RQLQ AR QOL JRQLQ No1 QOL ± % 88% 72% 73% (6) ) Mitakakis ) New South Wales (NSW)9 33 Personal Air Samplers Nasal Air Samplers Alternaria spores, Cladosporium spores, Alternaria spore spores/hr 11 Cladosporium spores spores/hr 4, 0 81 grains/hr grains/hr 5

9 ) PVDF ) IS IgE 2 2) 17, % 16.2%Okuda 3) 10,920 5, % 17.3% 19.4% 12.2%

10 4 6,7) 68.3% IgE Ozasa 8) % 7) Nakamura 10) ) QOL 12-14) 7) 3 (1) 14, 15

11 (2) a. QOL b. IgE IgE c. 3

12 13 IgE

13 1),,, 51: 15-19, ),,,, 105: , ) Okuda M.: Epidemiology of Japanese cedar pollinosis throughout Japan. Ann Allergy Asthma Immunol 91: , ) 4093: 17-24, ),,,, 21:64-65, ) ) ) Ozasa K, Dejima K, Takenaka H: Prevalence of Japanese cedar pollinosis among schoolchildren in Japan. Int Arch Allergy Immunol 128: , ) Okawa T, Konnno A, Yamakoshi T, Numata T, Terada N, Shima M: Analysis of natural history of Japanese cedar pollinosis. Int Arch Allergy Immunol 131:39-45, ) Nakamura H, Miyagawa K, Ogino K, Endo T, Imai T, Ozasa K, Motohashi Y, Matsuzaki I, Sasahara S, Hatta, Eboshida A. High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor -chain in Japanese cedar pollinosis. L Allergy Clin Immunol 112: , ),,,,,,,,

14 49: , ),,,,,,,, QOL 50 (7):1-7, ) QOL 200: , ),,,,,,,,,,,,, CrawfordBruce QOL (2002 ) 52 (Suppl.1): 21-56, ) Mitakakis TZ, Tovey ER, Xuan W, Marks GB: Personal exposure to allergenic pollen and mould spores in inland New South Wales, Australia. Clin Exp Allergy 30: , ),, (Cry j 1, Dac g) 51: , ) 200: , 2002.

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