第4回クッキーテスト研究会研究報告集(PDF)

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1 2007 H ()

2

3 2

4 () (g g kcal) mg/dl.mg/dl ( U/mlhr).(mg/dl*U/ml) cm 70.7kg 28.1kg/ 92.5cm ( ) () ( ) (.(.-.)g/ml.(-.) g/ml ((MS) MS MS cm 2 MS () 3

5 4 122/74 124/68 108/70 114/77 134/76 134/76 142/82 142/96 128/88 136/86

6 n=5 n=5 5

7 cm cm cm cm 6

8 7

9 Effects of Acarbose and Miglitol on plasma glucose and insulin concentrations after the test meal BS (mg/dl) IRI (microu/ml) A vs. M p= (ANOVA) M 120 >A 120 p<0.05 (Bonferroni/Dunn) A vs. M p= (ANOVA) M 120 >A 120 p<0.01 (Bonferroni/Dunn) Effects of Acarbose and Miglitol on peak FBF and FDR after the test meal FBF(ml/dl/min) % ** * * * * ** * Baseline 60min 120min Peak FBF Placebo Acarbose Miglitol ** * * * * * Baseline 60min 120min FDR 8

10 1) 2) 3) 4) 1) 2) 3) 4) 10 Cookie test LDL-CHOIRISa FRAS 4,, MC-FANmicro channel array flow analyzermc KH-6,100l Sa Sa IGTIFG IRI IGT Sa (2 )120 () HOMA-R Sa Ht LDL- ( ) ()IRI IRI HOMA-R

11 sec 90 HOMA-R;2.5< Sa time P<0.05 P<0.05 Pre 30 min 60 min 120 min Time (Sa time) (sec) p<

12 (Sa time) (sec) p<0.01 mg / dl) 11

13 12

14 13

15 14

16 15

17 16

18 *** ** ** ** 17

19 18

20 19

21 20

22 DMIGTIFG BMI 21

23 SM 23 / 31 6 /

24 23

25 24

26 25

27 key words: small dense LDL, Tel: Fax:

28 1ATG)B48 TG (mg/dl) (n=38) (n=19) (n=8) ApoB48 (mg/l) (n=19) (n=38) (n=8) h 2LDL phenotype, d<1.006 d<1.006(mm mm) d<1.006(mm mm) P< Pattern A Pattern B P< P< ns ns h A B 27

29 1. Proctor SD, Mamo JCL: Intimal retention of cholesterol derived from apolipoprotein B100- and apolipoprotein B48-containing lipoproteins in carotid arteries of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol 23: , Hirano T, Oi K, Sakai S, Kashiwazaki K, Adachi M, Yoshino G. High prevalence of small dense LDL in diabetic nephropathy is not directly associated with kidney damage: a possible role of postprandial lipemia. Atherosclerosis. 141:77-85,

30 29

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