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7 70% ADCA 28% SCA6 30% MJD 30% DRPLA 13% 20% SCA1 4% SCA2 3% RCA 2%

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18 537 25

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21 T2

22 C3 C6) LCL MRI

23 OB ph3 ph9

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25 60/40/20mg/ 1000mg/ 3 500mg/ 6

26 1000mg/ 3 6/

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29 %

30 / 24 (88%) 15 / 21 (71%) MS % 3 LCL: Long Cord Lesion 15 / 21 71% AQP4 1 2

31 MS Goodkin, D., et al.: Neurology 42: , 1992 Kurtzke, J. F.: Neurology 33: , 1983

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34 MRI MRI CIS RRMS SPMS McDonald MS

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39 β 2 β β β 3

40 4 APP)

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43 5% 95% ε 5 6

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45 7 n (n-3 PUFA) AD

46 8 β

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49 9 10 Integrated treatment approach, Combination therapy

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53 1 MRI

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57 3 MIBG 4

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59 3 MAO-B

60 4 7

61 4 a b 1 1 1

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