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1 50 2 Vol. 2 No. 999
2 0 Vol. 2 No. 999
3 Vol. 2 No. 999
4 5 Vol. 2 No
5 6 Vol. 2 No
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7 9 Vol. 2 No ,88 R
8 () CCU 0DNA (2) () () (2) 0 Vol. 2 No. 999
9 Vol. 2 No. 999 DIDI () (4) GCP GCP 00 0
10 600500,000 Evidence-Based Medicine POS 72,000, /FAX /22 /2 /7,0000,0005, /FAX Vol. 2 No. 999
11 ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Michaelis-Menten VmaxS V kms VS Vmax kmvmax Michaelis-MentenV SFDose/ Michaelis-Menten VmaxCss.ave SFDose/ kmcss.ave Css.aver SFDose/Css.aveCr Vol. 2 No
12 Css.ave Css.avekm Crphenytoin Vmax/kmVmaxkm Css.avekm Crphenytoin MichaelisMenten 9 CrVdKelKel0.69/t/2 t/2 t/26. VmaxCss.ave Css.aveCr kmcss.ave Vmax Crphenytoin kmcss.ave CrVd0.69/t/2 Vd0.69 t/2 Cr 6. Vd0.69 t/2phenytoin Vmax kmcss.ave Vd0.69 kmcss.ave 6.2 Vmax 60kg 2mg/L20mg/L 0.65L/kgVmax mg/kg/daykmmg/l 60kgVd9L Vmax7.5mg/h 2mg/L Vd0.69 t/2phenytoinkmcss.ave Vmax 9L0.69 mg/l2mg/l 7.5mg/h mg/L 9L0.69 t/2mg/l20mg/l 7.5mg/h mg/L Vol. 2 No. 999
13 7 Vol. 2 No. 999 Cfree Cbound Cpat Cadjust Alb.pat Alb.normal Cadjust 4.4mg/dl Cpat Cadjust Alb.pat Alb.normal 6. Cpat Cadjust Alb.pat Alb.normal Cfree CfreeCbound 5mg/L.0mg/dl 5mg/L 0. 2.mg/L 020mg/L 24 Cmax Cpat Cadjust 2.mg/L Alb.pat Alb.normal 5mg/L
14 LDphenytoin VdCmax LDphenytoin SF LD Vd Cmax F S 58kg 0mg/L L/kg 0.65L/kg58kg0mg/L LDphenytoin mg Michaelis-Menten VmaxCss.ave SFDose/ kmcss.ave Vmaxkm Vmaxkm VmaxCss.ave Dose kmcss.avefs cm 50kg 2mg/L F.0S.0 Vmaxmg/kg/daykmmg/L VmaxCss.ave Dose kmcss.avefs mg/kg50kg2mg/lday mg/l2mg/l mg/day F S.0 Vmaxkm VmaxCss.ave Dose kmcss.ave Dose DosekmVmax Css.ave Dose Vmax km Vmax/ Css.ave Dose/Css.aveDose y ax b x Dose/Css.avexDosey DoseCss.ave kmy Vmax Ludden mg/day mg/l 8 Vol. 2 No. 999
15 9 Vol. 2 No mg/day 0mg/L 2mg/L 260mgmg/L 00mg0mg/L Ludden Vmax476mg/daykmmg/L 2mg/L 7mg mg2mg/l 00mg/day 50mg/day 6.5 VmaxCss.ave Dose kmcss.ave 476mg2mg/Lday mg/l2mg/l 7.mg/day 6.7mg/L Population pharmacokinetics kmdose/ Css.ave VmaxDose/ mg/l50mg/day 476mg/day50mg/day 6.7mg/L
16 The rd Edition of Michael E. Winter's BASIC CLINICAL PHARMACOKINETICSApplied Therapiutics,Inc. Drug Information Vol.20No ng/ml0.52.0ng/ml Vol.2No.422.7L/kg0.5L/kg Vd=.7L/kg55kg=9.5LVd=0.5L/kg55kg=27.5L 9.5L.0mg/L2.mg/L 27.5L.0mg/L2.mg/L mg28.5mg 20 Vol. 2 No. 999
17 ddddddddddddddddddddddddddddddddddddddddddddd ddddddddddddddddddddddddddddddddddddddddddddd first impression Secord,P.E.,etal, Asch,S.E.,946 Vol. 2 No
18 24 Vol. 2 No. 999 PO X
19 25 Vol. 2 No. 999 Lederer,952
20 26 Vol. 2 No. 999 Kubler-Ross969 5 ü
21 27 Vol. 2 No No.79, FAX FAX
22 R R 28 Vol. 2 No. 999
23 29 Vol. 2 No R R R
24 Vol. 2 No
25 2 Vol. 2 No OUTPUT OUTPUT TIP 8 DI
26 Vol. 2 No ,000 2,
27 4 Vol. 2 No. 999
28 5 Vol. 2 No NARCISSINON Publius Ovidius Naso47 Narkissos
29 Narcissus narcissist Narcissism Daffodil Persephone Hãdẽs 0 PolyanthusnarcissusTazette narcisse à bouguets, Narcissus tazetta L 045cm 2.5 cmmm 2 Chinense sacred lily, Ntazetta Lvarchinensis Roem. 40cm jonquiljonquille jonquille Njonquilla L 045cm cm poet's narcissus Dichternarzisse jeannette Npoeticus L 045cm0.60.8cm 0cm 4.5cm.6cm daffodillentlilytrumpet narcissus OsterglockeTrompetenndrzisse 6 Vol. 2 No. 999
30 aiaultcoucoufaux narcisse Npseudonarcissus L 5cm0.5.cm cm 920 campernelle jonquil campernellegrande jonquille N odorus L 5cm 8cm.2cm 0 0cm cm m 2 0g25g 25g 0 5cm 2cm 5cm LicorineTazettine Glucomannane27 EugenolBenzaldehyde Benzoic acidester NarcissinLinalool Benzylacetate BenzylalcoholTerpineol cineol Vol. 2 No
31 , Vol. 2 No. 999
32 4 Vol. 2 No ,970,20, ,27,960 8,44 6,82 7,02 25,702 5,75 26,25 46,27 9,
33 42 Vol. 2 No , ,960,
34 HUS 9, HUS.4 6.Salmonella spp. 2.Vibrio parahaemolyticus.escharichia coli 4.Staphylococcus aureus 5.Clostridium perfringens 6.Bacillus cereus 7.Campylobacter jejuni 8.Campylobacter coli 9.Clostridium botulinum 0.Yersinia enterocolitica.vibrio choleras non-ol 2.Vibrio fluvaialis.vibrio mimicus 4.Aeromonas hydrophila 5.Aeromonas sobria 6. Plesiomonasshigelloides.Shigella spp. 2.Vibrio cholerae Ol.Salmonella serovar Typhi 4.Listeria monocytogenes 5.Yersinia pseudotuberculosis 6.Streptococcus spp. 7.Vibrio vulnificus.small Round Structured Virus 2. Vol. 2 No
35 44 Vol. 2 No , , ,
36 45 Vol. 2 No From Farm To Table , ,
37 HACCP , , , , , , , , , , ,758, ,29 46 Vol. 2 No. 999
38 47 Vol. 2 No. 999 NASA From Farm To Table O
39 48 Vol. 2 No // 0
40 Preventive Medicine Preventive Medicine nocebo effect placebo effect, 47 nocebo effect placebo effect , 50 Vol. 2 No. 999
41 Bri Med J Drug Development Research 9920 Lancet 958i08 J Clin Psychopharmacology bioequivalence Drug Development Research 9920 J Clin Psychopharmacology Bri J Psychiat Bri J Med PTP PTPpress through packing PTP press through packing MEDLINB PTPpress through packing PTPblister packblister pak blister wrappedtablet or capusule, blister PTP PTP PTP PTP PL lancet Otolaryngology Head and Neck Surgery Vol. 2 No
42 F TEL FAX
43 5 Vol. 2 No GDP5 HMOMGO MGO HMO OBRA 90
44 54 Vol. 2 No. 999 QOL SOAP SO A P HMO 65
45 55 Vol. 2 No ,600 6,6005,000 7,500 9,
46 Vol. 2 No. 999
47 200 OK Vol. 2 No
48 DI REPORT 58 Vol. 2 No. 999 DI NSG-L SG-L NSG SG-L SG N SG-L -L -N UHBKGApHNSL UHAGKBNSpH UHAGKBSpH UHAGKBNpH UHAGKSpH UHAGKBpH UHAGSpH UHAGKpH UHAGpH UAGpH HAGpH AGpH ApH GpH B H K U G'' '' '' BM0 BM9 BM9-RL BM8- BM6L BM5L BM6 BM S 8S 8 7S 7 6S 6 5 4U 4 A G B H K U 50,0,0,0,0,0,0,0,0,0,0,0, , , , , , , , , , , , ,
49 DI REPORT 59 Vol. 2 No. 999 BM4- BM- BMGPS- BMPGU- BMBU BMLN BM5000 BMS BM BMMAU 0s 0 9a 9s 8a 8s 7a 7s 6a 5a 5b 5 4a 4b a b h k -MN -M -Tf -Te -Tc -Kc -Pc -Tb -Db -Ga B 4U B K U 2 G P B 0EA 9EA 8EA 7EA 6EA 5EA 4EA L U GPB GPU B K U U-7 U-5 BIO-Gen8 BIO-Hemo GP/ ph-u , ,0,0,0,0,0, , , , , , , ,
50 Vol. 2 No. 999
51 6 Vol. 2 No
52 6 Vol. 2 No B D E A B C D E A
53 64 Vol. 2 No X YMCA 27 28
54 65 Vol. 2 No ,8074, ,
55 Vol. 2 No. 999
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