本文/YA3180C

Size: px
Start display at page:

Download "本文/YA3180C"

Transcription

1 pp. D- Frontier Science in Amino Acid and Protein Research L L D D-D-Asp Asp D Asp D L D L D L D L D L D L-D- Racemization of aspartyl residues of proteins in age-related disease Noriko FujiiResearch Reactor Institute, Kyoto University, Kumatori, Sennan, Osaka, Japan Yuichi KajiDepartment of Ophthalmology, Tsukuba University Institute of Clinical Medicine, Tennoudai, Tsukuba, Ibaraki, Japan LD- L- LD- D-L- L- D- L- L- L- L- L- L D D- D-Asp

2 D- D- αa- αb- D-Asp D-Asp D-Asp Asp, Asp Asp, Asp D-Asp D-Asp D-Asp β- D-Asp β- D-Ser D-Asp D- D-Asp D- D-Asp D-Asp Asp D-Asp α- αa- αb- αβγ- βγ- D-Asp Asp, Asp, Asp Ser, D-Asp D-Asp C D-Asp D-Asp Asp D-Asp D-Asp αaαb- Asp Asp AspDL αa Asp- β α Ser- αa Asp- β α Ala- αb Asp- β α Leu- αb Asp- β α Thr- αa-αb- kda αa- Asp AsnαB- Asp Asn AspAsn D αa-αb- HPLC AspAsn AspAsn DL αa-αb- Asp DL αa- Asp-Asp- αb- Asp-Asp- D AspAsn αa- Asp- DL Asp- DL D L Asp DL αa- αa-αb-l-asp D-Asp α β β-asp Asp D Asp L D α β L-α-

3 Asp Asp C α β D- D-α-Asp D-β-Asp L- L-α-AspL-β-Asp D- Asp Asp L D H Asp Asp αa- Asp-Asp- Ser-Ala- Asp Asp-Asp- αb- Asp- Asp- Asp αb- Asp-GlyAsn-Gly Asp Asp αa- Asp-Asp- DL I D- Asp

4 2 9 0 生化学 第8 0巻 第 4 号 図2 老人の顔の皮膚に存在する D-β-Asp 含有タンパク質 赤色部位 図3 瞼裂斑における D-β-Asp 含有タンパク質の局在 図4 加齢性黄斑変性における D-β-Asp 含有タンパク質の局在

5 αa- Asp- αa- Asp- D-β-Asp αa- Asp- D-β-Asp D-β-Asp Asp D-β-Asp D-β-Asp D-β-Asp D-β-Asp D-β-Asp kda D-β-Asp D-β-Asp spheroid degeneration D-β-Asp D-β-Asp D-β-Asp D-β-Asp D- D- L- Asp α β D-Asp α- β- β β D- β- D-Asp D-D-Ser Roher β- Asp-Asp-Asp- L-β-Asp D-Asp β- Asp- D β-β L β β- Asp L-β-Asp Asp Ser- D β- Ser- β-

6 D- D-Asp Masuda D-Asp I C CTx CTxAHDGGR Asp- CTx Asp- D-Asp Asp D-Asp Asp Asp Asp Asp A Asp A Asp GVADAAAAREGDPSSSAGADEGVR Asp DL Asp Asp Asp E kcalmol k GVADAAAA A- REGDPSSS A- AGADEGVR EkAsp Y Asp DL Y Asp DL Asp Asp Asp D L Asp Asp αa- αb- Asp D-Asp L-β-Asp PIMTprotein L- isoaspartyl methyltransferase D-α-Asp DAEPD-aspartyl endopeptidase Fujii, N., Satoh, K., Harada, K., & Ishibashi, Y.J. Biochem.,,. Fujii, N., Ishibashi, Y., Satoh, K., Fujino, M., & Harada, K. Biochim. Biophys. Acta,,. Kaji, Y., Oshika, T., Takazawa, Y., Fukayama, M., Takata, T., &Fujii, N.Invest. Ophthalmol. Vis. Sci.,,. Fisher, G.H., Garcia, N.M., Payan, I.L., Cadilla-Perezrios, R., Sheremata, W.A., & Man, E.H.Biochem. Biophys. Res. Commun.,,. Roher, A.E., Lowenson, J.D., Clarke, S., Wolkow, C., Wang,

7 R., Cotter, R.J., Reardon, I.M., Zurcher-Neely, H.A., Heinrikson, R.L., Ball, M.J., & Greenberg, B.D. J. Biol. Chem.,,. Kaneko, I., Yamada, N., Sakuraba, Y., Kamenosono, M., & Tutumi, S.J. Neurochem.,,. Fujii, N., Tajima, S., Tanaka, N., Fujimoto, N., Takata, T., & Shimo-Oka, T.Biochem. Biophys. Res. Commun.,,. Masuda, W., Nouso, C., Kitamura, C., Terashita, M., & Noguchi, T.Arch. Oral. Biol.,. Ritz, S., Turzynski, A., Schutz, H.W., Hollmann, A., & Rochholz, G.Forensic Sci. Int.,,. Cloos, P.A. & Fledelius, C.Biochem. J.,,. Powell, J.T., Vine, N., & Crossman, M.Atherosclerosis,,. Ritz-Timme, S., Laumeier, I., & Collins, M.Int. J. Legal Med.,,. Fujii, N., Harada, K., Momose, Y., Ishii, N., & Akaboshi, M. Biochem. Biophys. Res. Commun.,,. Fujii, N., Shimo-oka, T., Ogiso, M., Momose, Y., Kodama, M., & Akaboshi, M.,Mol. Vis.,,. Tomiyama, T., Asano, S., Furiya, Y., Shirasawa, T., Endo, N., &Mori,H.J. Biol. Chem.,,. Shimizu, T., Fukuda, H., Murayama, S., Izumiyama, N., & Shirasawa, T.Neurosci. Res.,,. Kuge, K., Fujii, N., Miura, Y., Tajima, S., & Saito, T. Amino Acids,,. McFadden, P.N. & Clarke, S.Proc. Natl. Acad. Sci. USA,,. Kinouchi, T., Ishiura, S., Mabuchi, Y., Urakami-Manaka, Y., Nishio, H., Nishiuchi, Y., Tsunemi, M., Takada, K., Watanabe, M., Ikeda, M., Matsui, H., Tomioka, S., Kawahara, H., Hamamoto, T., Suzuki, K., & Kagawa, Y.Biochem. Biophys. Res. Commun.,,.

本文/YA4278I

本文/YA4278I pp. D- D-DAO DAO D- D- D- D- o- DAO-D- D-DAO DAO Hans Krebs FAD X DAO DAO DAO D- Structure and reaction mechanism of D-amino acid oxidase Yasuzo Nishina School of Health Sciences, Kumamoto University,

More information

2007050781......_.L.O...z.W

2007050781......_.L.O...z.W a s d f g a s d f g h j k l 0 in vitro in vivo in vitro in vivo in vivo in vivo in vitro Metabolism Metabolism Endocr Endocr Endocrinol Ann NYA cad Sci J clin Endocr Metab

More information

Database Center for Life Science Online Service (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*,

Database Center for Life Science Online Service (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*, (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*, E mail : takaabe@mail.cc.tohoku.ac.jp Taro Tokui, Molecular identification of organic anion transporter

More information

表1.eps

表1.eps Vol.1 C ontents 1 2 cell-free EMBO J Proc. Natl. Acad. Sci. USA NatureEMBO J 3 RNA NatureEMBO J Nature EMBO J 4 5 HCV HCV HCV HCV RNA HCV in situ 6 7 8 Nat Struct Mol Biol J Biol Chem Nat Commun J Virol

More information

本文/YA3180B

本文/YA3180B pp. D- Frontier Science in Amino Acid and Protein Research D- D- D- D- D-Asp D-Asp D-Asp D- HPLC D- Asp PC D-Asp D- D- D- D-Asp D- D-Asp D- D- D- Asp D-Asp D- D-Asp D-Asp D-Asp D-Asp D- D- Biochemical

More information

1_alignment.ppt

1_alignment.ppt " " " " n " n n " n " n n n " n n n n " n LGPSSKQTGKGW-SRIWDN! + +! LN-ITKSAGKGAIMRLGDA! " n -------TGKG--------!! -------AGKG--------! " n w w w " n w w " " " 11 12 " n w w w " n w w A! M! O! A!

More information

1) van Meer, G., Op den Kamp, J. A.: J. Cell. Biochem., 19, 193-2040982) 2) Gaffet, P., Bettache, N., Bienvenue, A.: Biochemistry, 34, 6762-6769(1995) 3) Sims, P. J., Wiedmer, T.: Thromb. Haemost., 86,

More information

10中西_他.indd

10中西_他.indd Streptomyces mobaraensis N N N Sm b Sm N N Sm Sm Sm ' ' Sm Sm ak K k K bk k K Sm Sm a b S. mobaraensis a b a b Sm b b bb b b Sm Sm S. lividans ab Sm ab Sm ab ab ab ab SmSm S. lividansab S. lividans ab

More information

Bio-No.57/3....

Bio-No.57/3.... 2004. MAR. 3No.57 http://www.wako-chem.co.jp C O N T E N T S 2 Wako Bio Window No.57 MAR.2004 l l l l wako wako l l mmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmm Wako Bio Window No.57 MAR.2004 3 4 Wako Bio Window

More information

The function and structure of NAD kinase: the key enzyme for biosynthesis of NADP (H) Database Center for Life Science Online Service Key words Shigey

The function and structure of NAD kinase: the key enzyme for biosynthesis of NADP (H) Database Center for Life Science Online Service Key words Shigey The function and structure of NAD kinase: the key enzyme for biosynthesis of NADP (H) Key words Shigeyuki Kawai, Chikako Fukuda, Kousaku Murata E-mail : kawais@kais.kyoto-u.ac.jp, chikakko@kais.kyotou.ac.jp,

More information

Kazumitsu Ueda, [Department of Applied Life Science, Kyoto University Graduate School of Agriculture, Kitashirakawa, Sakyo-ku, Kyoto 606-01, Japan] Molecular Mechanisms for Drug Transport by MDR1/P-glycoprotein

More information

本文/YA6280C

本文/YA6280C H., Hoshino, K., Kaisho, T., Kuwata, H., Takeushi, O., Takeshige,K.,Saitoh,T.,Yamaoka,S.,Yamamoto,N.,Yamamoto, S., Muta, T., Takeda, K., & Akira, S.Nature,,. Yamazaki, S., Muta, T., Matsuo, S., & Takeshige,

More information

1949 1902 1872 1886 1873 04 UNIVERSITY OF TSUKUBA 2002 1973 1962 UNIVERSITY OF TSUKUBA 05 06 UNIVERSITY OF TSUKUBA UNIVERSITY OF TSUKUBA 07 10 UNIVERSITY OF TSUKUBA 105 UNIVERSITY OF TSUKUBA 11 1.85%

More information

Novel chemical mediators in the resolution of inflammation Charles N. Serhan Key words E-mail : marita@nih.go.jp Charles N. Serhan Brigham & Women's Hospital/Harvard Medical School 1) Serhan, C. N.,

More information

drug development Toshimi Michigami, E-mail : michigami@mch.pref.osaka.jp Keiichi Ozono, E-mail : keioz@ped.med.osaka-u.ac.jp The progress in the research on vitamin D 1) McCollum, E. V. et al.:

More information

Lipids of Seeds Manjiro NODA Department of Agricultural Chemistry, College of Agriculture, Kyoto Prefectural University (Sakyo-ku, Kyoto)

Lipids of Seeds Manjiro NODA Department of Agricultural Chemistry, College of Agriculture, Kyoto Prefectural University (Sakyo-ku, Kyoto) Lipids of Seeds Manjiro NODA Department of Agricultural Chemistry, College of Agriculture, Kyoto Prefectural University (Sakyo-ku, Kyoto) and Other Lipids", Vol. 11, p. 137 (1970) 2) C.Y. Hopkins,

More information

本文/YA3180D

本文/YA3180D pp. D- Frontier Science in Amino Acid and Protein Research D- D- N - D- D- D-DAP, EC D-DaaA Ser β- D D- Discovery of D-stereoselective amino acid amidases, and their use in kinetic resolution of amino

More information

VOL33NO.3/2010 A B A B p-erk1/2 Time (min) 0 1 2 5 10 15 30 60 90 120 Erk1/2 Time (min) 0 1 2 5 10 15 30 60 90 120 p-vasp VASP C D enos/gapdh x-fold vs sham 2.0 1.5 1.0 0.5 * 0 ANP (-) (+) (-)

More information

タンパク質を物性科学的に見た場合、単なるアミド結合の集合体であると片づけるにはもったいなさすぎる

タンパク質を物性科学的に見た場合、単なるアミド結合の集合体であると片づけるにはもったいなさすぎる Precise Functional Analysis of Biological Macromolecules Promoted by the Encounter of Crystallographic and Spectroscopic Molecular Structure Analyses Takamitsu Kohzuma*, Sachiko Yanagisawa, and Tomotake

More information

Correlation between molecular evolution of P450s and evolution of plant secondary metabolism Masaharu Mizutani E-mail : mizutani@scl.kyoto-u.ac.jp URL : http://biofun.kuicr.kyoto-u.ac.jp/index-j.html 13)

More information

tary adenylate cyclase activating polypeptide ; PA-

tary adenylate cyclase activating polypeptide ; PA- Conformation of a peptide ligand bound to its G-protein coupled receptor and its implication for ligand transportation tary adenylate cyclase activating polypeptide ; PA- molecular biology (ed. Rich,

More information

Microsoft Word - ■3中表紙(2006版).doc

Microsoft Word - ■3中表紙(2006版).doc 18 Annual Report on Research Activity by Faculty of Medicine, University of the Ryukyus 2006 FACULTY OF MEDICINE UNIVERSITY OF THE RYUKYUS α αγ α β α βγ β α β α β β β γ κα κ κ βγ ε α γδ β

More information

untitled

untitled Fig.1 t O O N,N p n J J J J J t J J J J J J J J J J J t t J J J J J J J J J p Fig.2 p t Fig.3 Fig.4 synanti p Table1 Table2t Table2 synanti antisyn synanti synanti Fig.5 syn anti anti Fig.6 Table3 Table4

More information

3) Z. Nambu: in preparation (1971). 4) N. P. Wilkins & J. D. Iles: Comp. Biochem. Physiol., 17, 1141 (1966). 5) V. M. Ingram: Nature, 235, 338 (1972). Bacillus cereus var. mycoides, Bacillus thuringiensis

More information

DNA Reck-Peterson DNA - - - - - DNA DNA DNA DNA A DNA DNA DNA DNA DNA nmnm nm B DNA DNA DNA SNAP Halo DNA DNA DNA - DNA -nm DNA DNA - A - DNA m B - C

DNA Reck-Peterson DNA - - - - - DNA DNA DNA DNA A DNA DNA DNA DNA DNA nmnm nm B DNA DNA DNA SNAP Halo DNA DNA DNA - DNA -nm DNA DNA - A - DNA m B - C !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! DNA ICT Cooperative activation of motor proteins revealed by bioimaging and a high-speed optical tweezer Kenya Furuta, Takayuki Torisawa

More information

The Heart Healthy Tocotrienol Complex Tocomin SupraBio

The Heart Healthy Tocotrienol Complex Tocomin SupraBio The Heart Healthy Tocotrienol Complex Tocomin SupraBio The Heart Healthy Tocotrienol Complex Tocomin SupraBio 1. Fact Sheet No. 317; World Health Organization (WHO), 2007 2. LLOYD-JONES D. et al. Circulation

More information

Juntendo Medical Journal

Juntendo Medical Journal The hair growth effect of minoxidil Susumu OTOMO, Ph. D. Key words : minoxidil, minoxidil sulfate, hair growth, K+-channel opener, male pattern baldness Dept. of Pharmacology, Research Center Taisho Pharmaceutical

More information

Spatio-temporal regulation of ERK1/2 MAP kinase 20) Murphy, L. 0., MacKeigan, J. P., Blenis, J.: Mol. Cell. Biol., 24, 144-153 (2004) 21) Harada, T., Morooka, T., Ogawa, S., Nishida, E.: Nature Cell

More information

4) H. Takayama et al.: J. Med. Chem., 45, 1949 (2002). 5) H. Takayama et al.: J. Am. Chem. Soc., 112, 8635 (2000). 6) H. Takayama et al.: Tetrahedron Lett., 42, 2995 (2001). 9) M. Kitajima et al: Chem.

More information

本文/YA9255F

本文/YA9255F pp. ATP ε ATP ATP ATP ε Bacillus PS ATP ATP H H µ H ATP ATP ADP µ H ATP FoF -ATP FoF -ATP µ H H ADP ATP H Na On the regulatory role of the epsilon subunit in ATP synthase Yasuyuki Kato-Yamada Department

More information

Database Center for Life Science Online Service Signal transduction of growth factor mediated by heparin heparan sulfate

Database Center for Life Science Online Service Signal transduction of growth factor mediated by heparin heparan sulfate Signal transduction of growth factor mediated by heparin heparan sulfate 1) Zhu. X.. Komiya, H., Chirino, A.. Faham. S.. Fox, G. M., Arakawa, T., Hsu, B.T., Rees, D. C.: Science. 251, 90-93 (1991)

More information

日本皮膚科学会雑誌第121巻第11号

日本皮膚科学会雑誌第121巻第11号 β Clin Rheumatol Arthritis Rheum Am J Cardiol J Rheumatol J Rheumatol Arthritis Rheum Arthritis Rheum Arthritis Rheum Rheumatology Oxford Rheumatology Oxford Br J Dermatol Arch Dermatol Ann Rheum Dis

More information

5200) [Department of Biochemistry, Miyazaki Medical College, Kihara, Kiyotake-cho, Miyazaki 889-16, Japan] Natriuretic Peptide Family: ANP and BNP 1) de Bold, A. J.: Science, 230, 767-770 (1985)

More information

64) M.L. Gefter, R.L. Russell: J. Mol. Biol., 39, 145 (1969) 65) F. Harada, F. Kimura and S. Nishimura: Biochim. Biophys. Acta., 182, 590 (1969) 65a) F.H.C. Crick: J. Mol, Biol., 19, 548 (1966); M. Nirenberg

More information

色覚(初組4).pm

色覚(初組4).pm 733 3 1 520 1 8 4 0.2500 1 30012 1 AB 3 22 3 1 2 http://www.nig.ac.jp/labs/devgen/mou.html 734 1.1 360nm 830nm 380nm 780nm 540nm 580nm 660nm 540nm 660nm Log relative corneal sensitivity 0 1 2 400 500 600

More information

Database Center for Life Science Online Service Miho Shimizu, [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sap

Database Center for Life Science Online Service Miho Shimizu, [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sap Miho Shimizu, [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060, Japan] Molecular Basis of Triplet Repeat Diseases : Genetic Instabillity and Unusual DNA

More information

寄稿論文 高い発ガン活性を示す鉄キレートお構造特性 | 東京化成工業

寄稿論文 高い発ガン活性を示す鉄キレートお構造特性 | 東京化成工業 NTBI = nontransferrin-bound iron NTBI DNA H DNA 2 NTBI NTBI NTBI NTBI NTBI NTBI (nta) (nta) (nta) NTBI (nta) (nta) NTBI (nta)ntbi Fe-(nta) (nta) N(CH 2 CH) 3 HCCH 2 NHCH 2 CH 2 NHCH 2 CH (HCCH 2 ) 2 NH

More information

本文/YA9255C

本文/YA9255C pp. E- -SH X in vitro in vivo -SH Structure-based drug development and medical biological application of cathepsin specific inhibitors Nobuhiko Katunuma Institute for Health Sciences, Tokushima Bunri University,Nishihamabouji,

More information

Database Center for Life Science Online Service Natronobacterium pharaonis Crystal structure of phoborhodopsin : Mechanisms of color tuning and signal

Database Center for Life Science Online Service Natronobacterium pharaonis Crystal structure of phoborhodopsin : Mechanisms of color tuning and signal Natronobacterium pharaonis Crystal structure of phoborhodopsin : Mechanisms of color tuning and signal transduction Needleman, R., Lanyi, J. K. : Science, 269,73-75 (1995) 3) Bogomolni, R. A., Stoeckenius,

More information

2007 Vol.56 No.6 総説 丸山浩樹

2007 Vol.56 No.6 総説 丸山浩樹 Reprinted from RADIOISOTOPES, Vol.56,.6 June 2007 Japan Radioisotope Association http : //www.jrias.or.jp/ α β α β ε m z α µ µ α m z m z µ µ Curr. Opin. Biotechnol J. Proteome Res Rapid Commun. Mass

More information

1) Y. Hatefi: Annu. Rev. Biochem., 54, 1015 (1985). 2) H. Weiss, T. Friedrich, G. Hofhaus & D. Preis: Eur. 4) M. Yamaguchi & Y. Hatefi: Biochemistry, 32, 1935 (1993). 5) K. Leonard, H. Haiker & H. Weiss:

More information

本文/AY380L

本文/AY380L RNA- RNA RNA Nanotechnology & Therapeutics Lexington RNA Salt Lake City FNANO FNANO RNA RNA RNA- RNP RNA DNA DNA DNA RNA RNA ips CiRA RNA-Protein nanotechnology & synthetic biology Hirohide Saito The Hakubi

More information

受賞講演要旨2012cs3

受賞講演要旨2012cs3 アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート アハ ート α β α α α α α

More information

[Department of Pediatrics, Gifu University School Clinical. Pathological and Biochemical Abnormality in peroxisomal Disorders 1) Goldfischer, S., Moore, C. L., Johnson, A. B., Spiro, A. J., Valsamis,

More information

Various function and toxicity of iron Key words 1) Hentze, M. W. et al: Cell, 117, 285-297 (2004) 2) Ganz, T.: Blood, 102, 783-788 (2003) 3) Nemeth, E. et al.: Science, 306, 2090-2093 (2004) 4) Hentze,

More information

.i...j...[.X8-2

.i...j...[.X8-2 Vol. 8 No.2 Nov. 2007 1 2 4 12 20 37 45 54 56 62 1 2 3 4 5 7 6 8 9 10 11 13 12 15 14 17 16 19 18 21 20 Hatena 23 22 Oidiodendron Oidiodendron 25 24 Monosiga ovata Monosiga 27 26 Toxoplasma gondii 29 28

More information

University of Tsukuba2014

University of Tsukuba2014 University of Tsukuba S c h o o l o f H e a l t h & P h y s i c a l E d u c a t i o n University of Tsukuba 2014 http://www.taiiku.tsukuba.ac.jp University of Tsukuba2014 School of Health & Physical Education,

More information

VITAMIN _R21172(高解像度).pdf

VITAMIN _R21172(高解像度).pdf 280 89 2014 11 AREDS I AREDS I AMD AREDS I AMD AMD AREDS I DHA EPA AMD AREDS II 2006-2012 1 2 AREDS II GRAS Generally Recognized as a Safe FAO/WHO JECFA 1 2 mg/kg 2006 OSL Observed Safety Level 20 mg/

More information

日本皮膚科学会雑誌第122巻第2号

日本皮膚科学会雑誌第122巻第2号 J Dermatol Sci Vitam Horm NEnglJMed Lancet J Clin Invest Antitoxid Redox Signal Diabetes Metab Res Rev Diabetes Care Diabet Med Diabetes care Diabetes Care J Foot Ankle Surg Wound Repair Regen Lancet Foot

More information

一般演題(ポスター)

一般演題(ポスター) 6 5 13 : 00 14 : 00 A μ 13 : 00 14 : 00 A β β β 13 : 00 14 : 00 A 13 : 00 14 : 00 A 13 : 00 14 : 00 A β 13 : 00 14 : 00 A β 13 : 00 14 : 00 A 13 : 00 14 : 00 A β 13 : 00 14 : 00 A 13 : 00 14 : 00 A

More information

日本皮膚科学会雑誌第122巻第7号

日本皮膚科学会雑誌第122巻第7号 Br J Dermatol NEnglJ Med 尋常性白斑診療ガイドライン 図 1 先天性白斑 白皮症の病型分類 図 2 後天性白斑 白皮症の病型分類 の尋常性白斑患者で家系内発症がみられることより 3 5 れらの合併が染色体 17p13 における一塩基多型に起 非分節 因し その候補遺伝子の一つが自然免疫に重要とされ 型に含まれる汎発型には甲状腺に対する抗サイログロ る NALP1 遺伝子であると報告している6

More information

P1-1 P1-2 P1-3 P1-4 P1-5 P1-6 P3-1 P3-2 P3-3 P3-4 P3-5 P3-6 P5-1 P5-2 P5-3 P5-4 P5-5 P5-6 P7-1 P7-2 P7-3 P7-4 P7-5 P7-6 P9-1 P9-2 P9-3 P9-4 P9-5 P9-6 P11-1 P11-2 P11-3 P11-4 P13-1 P13-2 P13-3 P13-4 P13-5

More information

ü β 93

ü β 93 Amyloid Fibril Formation and Protein Science Yuji GOTO Institute for Protein Research, Osaka University E-mail: ygoto@protein.osaka-u.ac.jp Abstract: Amyloid fibrils have been a critical subject in recent

More information

Database Center for Life Science Online Service Discovery, analysis and chemical mechanism of protein splicing

Database Center for Life Science Online Service Discovery, analysis and chemical mechanism of protein splicing Discovery, analysis and chemical mechanism of protein splicing VMA1 VMA1 2) Anraku, Y.: Genes to Cells, 2, 359-367 (1997) 3) Perler, F. B.: Cell, 92,1-4 (1998) 4) Perler, F. B.: Trends Biochem.

More information

1 913 10301200 A B C D E F G H J K L M 1A1030 10 : 45 1A1045 11 : 00 1A1100 11 : 15 1A1115 11 : 30 1A1130 11 : 45 1A1145 12 : 00 1B1030 1B1045 1C1030

1 913 10301200 A B C D E F G H J K L M 1A1030 10 : 45 1A1045 11 : 00 1A1100 11 : 15 1A1115 11 : 30 1A1130 11 : 45 1A1145 12 : 00 1B1030 1B1045 1C1030 1 913 9001030 A B C D E F G H J K L M 9:00 1A0900 9:15 1A0915 9:30 1A0930 9:45 1A0945 10 : 00 1A1000 10 : 15 1B0900 1B0915 1B0930 1B0945 1B1000 1C0900 1C0915 1D0915 1C0930 1C0945 1C1000 1D0930 1D0945 1D1000

More information

J Life Sci Res 2014; 12: Osaka Prefecture University Journal of Life Science Research Online ISSN

J Life Sci Res 2014; 12: Osaka Prefecture University Journal of Life Science Research Online ISSN J Life Sci Res 2014; 12: 15-19 2014 Osaka Prefecture University Journal of Life Science Research Online ISSN 2186-5809 583-8555 3-7-30 577-8567 3-1-1 2014 9 11 2014 10 21 Exposure mild-level LED light

More information

Graduate School of Clinical Psychology, Kibi International University 8 Iga-machi, Takahashi, Okayama, Japan(716-8508) Research Institute of Clinical Psychology, Kibi International University Department

More information

本文/YAY116K

本文/YAY116K pp. GH GH GH β- - D- β- β- β- - EC J Alkalitolerant mechanism and improvement of alkalitolerancy of glycoside hydrolases Satoshi Nakamura Department of Bioengineering, Tokyo Institute of Technology, J

More information

15K00827 研究成果報告書

15K00827 研究成果報告書 (TG) TG sterol regulatory element- binding protein (SREBP)-1c (Diabetes 53:560-569, 2004) SREBP-1c (1) SREBP-1c SREBP-1c liver X receptor (LXR)LXR O-Glc NAc (O-linked -N-acetyl glucosamine) (J Biol Chem

More information

Kazumitsu Ueda, E-mail : uedak@kais.kyoto-u.ac.jp http : //cseika-1, kais.kyoto-u.ac.j p Molecular mechanism of multidrug transporter MDR I : ABC in host-defense machinery 32P-ATP 1) Chen, C., Chin,

More information

P-12 P-13 3 4 28 16 00 17 30 P-14 P-15 P-16 4 14 29 17 00 18 30 P-17 P-18 P-19 P-20 P-21 P-22

P-12 P-13 3 4 28 16 00 17 30 P-14 P-15 P-16 4 14 29 17 00 18 30 P-17 P-18 P-19 P-20 P-21 P-22 1 14 28 16 00 17 30 P-1 P-2 P-3 P-4 P-5 2 24 29 17 00 18 30 P-6 P-7 P-8 P-9 P-10 P-11 P-12 P-13 3 4 28 16 00 17 30 P-14 P-15 P-16 4 14 29 17 00 18 30 P-17 P-18 P-19 P-20 P-21 P-22 5 24 28 16 00 17 30 P-23

More information

本文/YA7261E

本文/YA7261E J. Cell Biol.,,. Segev, N.Curr. Opin. Cell Biol.,,. Lafont, F., Lecat, S., Verkade, P., & Simons, K.J. Cell Biol.,,. Mostov, K.E., Verges, M., & Altschuler, Y.Curr. Opin. Cell Biol.,,. Sato, T., Mushiake,

More information

YK250 Human GIP (Active) ELISA FOR RESEARCH LABORATORY USE ONLY FAX: TEL: Website: E-mai

YK250 Human GIP (Active) ELISA FOR RESEARCH LABORATORY USE ONLY FAX: TEL: Website:   E-mai YK250 Human GIP (Active) ELISA FOR RESEARCH LABORATORY USE ONLY 418-0011 2480-1 FAX: 0544-22-2770 TEL: 0544-22-2771 Website: www.yanaihara.co.jp E-mail: ask@yanaihara.co.jp . 2. 3. 4. 56. 7. 812. 12. 1213

More information

Database Center for Life Science Online Service 35) [Laboratory of Hepatitis Viruses II, Department of Enteroviruses, National Institute of Health, Ka

Database Center for Life Science Online Service 35) [Laboratory of Hepatitis Viruses II, Department of Enteroviruses, National Institute of Health, Ka 35) [Laboratory of Hepatitis Viruses II, Department of Enteroviruses, National Institute of Health, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan] Hepatitis C Virus 1) Choo, Q.-L., Kuo, G., Weiner,

More information

untitled

untitled 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Int J Radiat Oncol Biol Phys 49 Cancer 101 Int J Radiat Oncol Biol Phys 60 Chest 124 Int J Radiat Oncol Biol Phys 56 Int J Radiat Oncol Biol Phys 49 Chest 124 Int J

More information

本文/AY380P

本文/AY380P ARF-like GTPase RAS G RAS, RHO RAC, RAB, ARF ARL, RAN ARF RAB G ARF-like ARL GTPase ARF G ARL GTPase ARF ARL GTPase G ARF ARL GTPase-activating proteins GAPs ARF G N ARF N ARF GDP GTP N ARL ARL ARF N ARL

More information

Database Center for Life Science Online Service Vol.48 No.16 (2003)

Database Center for Life Science Online Service Vol.48 No.16 (2003) Database Center for Life Science Online Service Key words Kikuya Kato, E-mail : kkato@bs.aist-nara. ac.jp http://love2.aist-nara.ac.jp Shin Ishii, E-mail : ishii@is.aist-nara.ac.jp http://hawaii.aist-nara.

More information

444 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. +*,..../. (,**2) 12 Present State and Issues of Rice Powder Utilization : Rice Bread Koh-ichi Yo

444 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. +*,..../. (,**2) 12 Present State and Issues of Rice Powder Utilization : Rice Bread Koh-ichi Yo 444 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. +*,..../. (,**2) 12 Present State and Issues of Rice Powder Utilization : Rice Bread Koh-ichi Yoza, Mayuko Okabe and Jun Shima National Food Research

More information

Database Center for Life Science Online Service School of Medicine, Seiryo-machi, Sendai 980, Japan] Biological Role of NDP-kinase in Cell Proliferati

Database Center for Life Science Online Service School of Medicine, Seiryo-machi, Sendai 980, Japan] Biological Role of NDP-kinase in Cell Proliferati School of Medicine, Seiryo-machi, Sendai 980, Japan] Biological Role of NDP-kinase in Cell Proliferation and Activation Mechanism of GTP Binding Proteins by the Enzyme 3) Nishizuka, Y.: Nature,

More information

2 350 1610

2 350 1610 2 350 1610 1 2 3 1 1 2 2 3 3 4 5 1 11 20 34 47 49 50 52 53 62 70 75 89 100 116 119 121 126 147 148 163 167 qqqqqqqq qqqqqqqq 1 9 2 24 3 33 4 36 5 40 6 47 7 54 8 56 9 64 10 78 11 86 12 94 13 129 14 151

More information