医薬品リスク管理計画書

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1

2 2.5 mg 3.75 mg 5 mg 20mg RMP 2.5 mg 3.75 mg 5 mg 20mg TTP 9 梗 6 TIA CABG mg RMP

3 AMX AMX AMX AMX mg 3.75 mg 5 mg 20 mg mg 2.5 mg mg 3.75 mg mg 5 mg 1 22 mg 20 mg 20 mg mg 1

4 PCI ST 梗 ST 梗 梗 2

5

6 III ACS-PCI III PCI CABG 45.7% 482 / % 13 /1055 1) 1 PCI III CABG 5 g/dl

7 III ACS-PCI III PCI 1.3% 14 /1055 ACS III 1. TTP 1. TTP TTP 5

8 III ACS-PCI III PCI 0.7% 7 /1055 ACS III 1. III ACS-PCI III PCI 0.1% 1 /1055 ACS III 1. 6

9 7

10 III ACS-PCI III PCI 3.8% 40 /

11 ACS III ACS III 1. 9

12

13 梗 梗 TIA III ACS-PCI III PCI 1. 梗 TIA 梗 TIA 1. 11

14 1. CABG CABG 1. 12

15 CABG CABG PCI PCI PCI PCI 48 13

16 1. 14

17 PCI kg mg 2.5 mg 3.75 mg 2.5 mg 15

18 2. TTP 梗 TIA CABG ACS ACS ,000 1) 2) 2) 3) 25% 16

19 2% 4% 2 5% 80% 3, % 4,000 1) Marui A et al., Ann Thorac Surg, 91 (5), (2011) 2) Shihara M, et al., Circ J, 66 (1), (2002) 3) Kushiro T et al., J Hum Hypertens, 26 (6), (2012)

20

21 4. MR 6 MR 6 19

22 20

23 ,

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