Microsoft PowerPoint - MRカラー(國澤)

Size: px
Start display at page:

Download "Microsoft PowerPoint - MRカラー(國澤)"

Transcription

1 Purinergic signaling mediates mast cell activation in intestinal inflammation Yosuke Kurashima, Hiroshi Kiyono and Jun Kunisawa Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minatoku, Tokyo, Japan; Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Asagi Saito, Ibaraki, Osaka, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan - TNF IL- NOD WBBFkit-Kit w Kit w-v c-kit WBBF-Kit WW-v Kraneveld TNF WBBF-Kit WW-v T c-kit CBL-Kit W-shW-sh T CBL-Kit W-shW-sh c-kit DTDTR pp.

2 toxin receptor mediated conditional cell knock outtreck CBL-Kit W-shW-sh mast cell specific-treckmas-treck MaS-TRECK IL- HS IE DTR MaS-TRECK DT CBL-Kit W-shW-sh MaS-TRECK Kraneveld A CD A in vitro IgE A A A CD IgE L L IgE L T B CD F F ATP PX ATP Burnstock ATP purinergic hypothesis ATP PX PY ATP PX PX PX PX PX PX C ATP pore C pore ATP K efflux NLRP IL- IL- ATP ATP GVHD ATP ATP ATP T Th

3 Pannexin-Panx ConnexinConx ATP PX PY CDCD ADP-PY ATP ATP T Th ATP CDCD ATP PXF PXATP CD- CCL CXCL IL-IL-TNF CD PX ATP F PX PX PX PX ATP-PX PX PX PX ATP ATP CD CD ATP ATPADPAMP ATP AB A ATP ADP ATP

4 PX ATP ATP PX ATP ADPAMP ATP ATP ATP ADP PX ATP ADP ADP PX ADP ATP ATP Pannexin- Connexin ADP ADPATP ADPATP ATP diadenosine pentaphosphateadp UDP ADP ADP ATP ATP ADP ATP PX ATP ADP ATP PX ATP PX PX PX ATP Kaser, A., Zeissig, S., Blumberg, R.S.Annu. Rev. Immunol.,,. Kurashima, Y., Goto, Y., Kiyono, H.Eur. J. Immunol.,,. Hamilton, M.J., Sinnamon, M.J., Lyng, G.D., Glickman, J.N., Wang, X., Xing, W., Krilis, S.A., Blumberg, R.S., Adachi, R., Lee, D.M., Stevens, R.L. Proc. Natl. Acad. Sci. USA,,. Rijnierse, A., Redegeld, F.A., Blokhuis, B.R., Van der Heijden, M.W., Te Velde, A.A., Pronk, I., Hommes, D.W., Nijkamp, F. P., Koster, A.S., Kraneveld, A.D.J. Immunol.,,. Reber, L.L., Marichal, T., Galli, S.J.Trends Immunol.,,. Kurashima, Y., Amiya, T., Nochi, T., Fujisawa, K., Haraguchi, T., Iba, H., Tsutsui, H., Sato, S., Nakajima, S., Iijima, H., Kubo, M., Kunisawa, J., Kiyono, H.Nat. Commun.,,. doi:.ncomms. Idzko, M., Ferrari, D., Eltzschig, H.K.Nature.,,. Junger, W.G.Nat. Rev. Immunol.,,. Ochoa-Cortes, F., Liñán-Rico, A., Jacobson, K.A., Christofi, F.L.Inflamm. Bowel Dis.,,. Burnstock, G.Eur. J. Pharmacol.,,. Colgan, S.P. Eltzschig, H.K.Annu. Rev. Physiol.,,. Kurashima, Y. Kiyono, H.Exp. Mol. Med.,, e. doi:.emm.. Marques, C.C., Castelo-Branco, M.T., Pacheco, R.G., Buongusto, F., do Rosário, A. Jr., Schanaider, A., Coutinho-Silva, R., de, Souza, H.S.Biochim. Biophys. Acta,,

5 . Neves, A.R., Castelo-Branco, M.T., Figliuolo, V.R., Bernardazzi, C., Buongusto, F., Yoshimoto, A., Nanini, H.F., Coutinho, C.M., Carneiro, A.J., Coutinho-Silva, R., de Souza, H.S.Inflamm. Bowel Dis.,,. Kurashima, Y., Amiya, T., Fujisawa, K., Shibata, N., Suzuki, Y., Kogure, Y., Hashimoto, E., Otsuka, A., Kabashima, K., Sato, S., Sato, T., Kubo, M., Akira, S., Miyake, K., Kunisawa, J., Kiyono, H.Immunity,,. DCPD

2007050781......_.L.O...z.W

2007050781......_.L.O...z.W a s d f g a s d f g h j k l 0 in vitro in vivo in vitro in vivo in vivo in vivo in vitro Metabolism Metabolism Endocr Endocr Endocrinol Ann NYA cad Sci J clin Endocr Metab

More information

19 8 1970 20 10 4 1

19 8 1970 20 10 4 1 19 8 1970 20 10 4 1 IgE 1960 % 1970 20%, 1990 40% 1998 70% 20 IgE 21 90% IgE IgE (%) 70 60 50 40 30 20 10 0 1970 1975 1980 1985 1990 1995 2000 2005 1. 2005 10 2 30 IgE 2. 3 1. B IgE T IgE IgE IgE 2 T IgE

More information

表1.eps

表1.eps Vol.1 C ontents 1 2 cell-free EMBO J Proc. Natl. Acad. Sci. USA NatureEMBO J 3 RNA NatureEMBO J Nature EMBO J 4 5 HCV HCV HCV HCV RNA HCV in situ 6 7 8 Nat Struct Mol Biol J Biol Chem Nat Commun J Virol

More information

Novel chemical mediators in the resolution of inflammation Charles N. Serhan Key words E-mail : marita@nih.go.jp Charles N. Serhan Brigham & Women's Hospital/Harvard Medical School 1) Serhan, C. N.,

More information

Database Center for Life Science Online Service (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*,

Database Center for Life Science Online Service (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*, (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*, E mail : takaabe@mail.cc.tohoku.ac.jp Taro Tokui, Molecular identification of organic anion transporter

More information

Florigen in rice Key words Shojiro Tamaki, Ko Shimamoto E-mail : s-tamaki@bs.naist.jp, simamoto@bs.naist.jp URL : http://bsw3.naist.jp/simamoto/simaoto.html 1) Thomas, B., Vince-prue, D.: Photoperiodism

More information

10中西_他.indd

10中西_他.indd Streptomyces mobaraensis N N N Sm b Sm N N Sm Sm Sm ' ' Sm Sm ak K k K bk k K Sm Sm a b S. mobaraensis a b a b Sm b b bb b b Sm Sm S. lividans ab Sm ab Sm ab ab ab ab SmSm S. lividansab S. lividans ab

More information

untitled

untitled Fig.1 t O O N,N p n J J J J J t J J J J J J J J J J J t t J J J J J J J J J p Fig.2 p t Fig.3 Fig.4 synanti p Table1 Table2t Table2 synanti antisyn synanti synanti Fig.5 syn anti anti Fig.6 Table3 Table4

More information

The Plasma Boundary of Magnetic Fusion Devices

The Plasma Boundary of Magnetic Fusion Devices ASAKURA Nobuyuki, Japan Atomic Energy Research Institute, Naka, Ibaraki 311-0193, Japan e-mail: asakuran@fusion.naka.jaeri.go.jp The Plasma Boundary of Magnetic Fusion Devices Naka Fusion Research Establishment,

More information

1) Murphy, T.H., Miyamoto, M., Sastre, A., Schnaar, R.L., Coyle, J.T.: Neuron, 2, 1547-1558 (1989) 2) Pellegrini-Giampietro, D.E., Cherici, G., Ale siani,m., Carla, V., Moroni, F.: J. Neuro science,10,

More information

本文/AY380J

本文/AY380J MHC-II II MHC-II MHC- II CD T T TCR T T MHC-II MHC-II T MHC-II MHC-II MHC-II MHC-II Ii Ii-MHC-II MHC-II antigen processing compartment MIIC Regulation of cell surface expression of MHC-II in dendritic

More information

2. 研究実施内容 ( 文中に番号がある場合は (3-1) に対応する ) (1) 清野 グループ 1.Alcaligenes を中心とするパイエル板内共生細菌による慢性炎症制御機構の解明平成 24 年度はペンシルバニア大学の David Artis 先生との共同研究により 腸管での生体防御や炎症

2. 研究実施内容 ( 文中に番号がある場合は (3-1) に対応する ) (1) 清野 グループ 1.Alcaligenes を中心とするパイエル板内共生細菌による慢性炎症制御機構の解明平成 24 年度はペンシルバニア大学の David Artis 先生との共同研究により 腸管での生体防御や炎症 炎症の慢性化機構の解明と制御に向けた基盤技術の創出 平成 22 年度採択研究代表者 H24 年度 実績報告 清野宏 東京大学医科学研究所 教授 炎症性腸疾患の慢性化制御機構の解明と治療戦略の基盤構築 1. 研究実施体制 (1) 清野 グループ 1 研究代表者 : 清野宏 ( 東京大学医科学研究所 教授 ) 2 研究項目 炎症性腸疾患の慢性化制御機構の解明と治療戦略の基盤構築 (2) 高橋 グループ

More information

Various function and toxicity of iron Key words 1) Hentze, M. W. et al: Cell, 117, 285-297 (2004) 2) Ganz, T.: Blood, 102, 783-788 (2003) 3) Nemeth, E. et al.: Science, 306, 2090-2093 (2004) 4) Hentze,

More information

本文/YA1174C

本文/YA1174C RecF DNA RecA DNA RecA RecF Steve Kowalczykowski Susan Lovett RecJ Mimitou, E.P. & Symington, L.S.Nature,,. Zhu, Z., Chung, W.H., Shim, E.Y., Lee, S.E., & Ira, G. Cell,,. Gravel, S., Chapman, J.R., Magill,

More information

Database Center for Life Science Online Service 35) [Laboratory of Hepatitis Viruses II, Department of Enteroviruses, National Institute of Health, Ka

Database Center for Life Science Online Service 35) [Laboratory of Hepatitis Viruses II, Department of Enteroviruses, National Institute of Health, Ka 35) [Laboratory of Hepatitis Viruses II, Department of Enteroviruses, National Institute of Health, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan] Hepatitis C Virus 1) Choo, Q.-L., Kuo, G., Weiner,

More information

1) van Meer, G., Op den Kamp, J. A.: J. Cell. Biochem., 19, 193-2040982) 2) Gaffet, P., Bettache, N., Bienvenue, A.: Biochemistry, 34, 6762-6769(1995) 3) Sims, P. J., Wiedmer, T.: Thromb. Haemost., 86,

More information

/‚“1/ŒxŒ{‚×›î’æ’¶

/‚“1/ŒxŒ{‚×›î’æ’¶ 60 1 pp.3-8 2010 1. H1N1 1) 2) 3) 4) ERATO 2009 H1N1 21 H1N1 HA PB2 2009 3 Pandemic H1N1 2009 WHO 6 11 21 2009 11 2010 4 21 H1N1 H1N1 2009 4 15 CDC 108-8639 4-6-1 TEL: 03-5449-5281 FAX: 03-5449-5408 E-mail:

More information

Graduate School of Clinical Psychology, Kibi International University 8 Iga-machi, Takahashi, Okayama, Japan(716-8508) Research Institute of Clinical Psychology, Kibi International University Department

More information

合併後の交付税について

合併後の交付税について (1) (2) 1 0.9 0.7 0.5 0.3 0.1 2 3 (1) (a), 4 (b) (a), (c) (a) 0.9 0.7 0.5 0.3 0.1 (b) (d),(e) (f) (g) (h) (a) (i) (g) (h) (j) (i) 5 (2) 6 (3) (A) (B) (A)+(B) n 1,000 1,000 2,000 n+1 970 970 1,940 3.0%

More information

Short Review Hidenori Takagi, Fumio Takaiwa, E-mail : takaiwa@nias.affrc.go.jp 13) Hirahara, K. et al. : J. Allergy Clin. Immunol., 102, 961-967 (1998) 14) Takagi, H. et al.: Proc. Natl. Acad. Sci.

More information

肺癌第50巻第4号

肺癌第50巻第4号 1 Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan; 2 Department of Thoracic Surgery, Aichi Cancer Center, Japan;

More information

物理化学I-第12回(13).ppt

物理化学I-第12回(13).ppt I- 12-1 11 11.1 2Mg(s) + O 2 (g) 2MgO(s) [Mg 2+ O 2 ] Zn(s) + Cu 2+ (aq) Zn 2+ (aq) + Cu(s) - 2Mg(s) 2Mg 2+ (s) + 4e +) O 2 (g) + 4e 2O 2 (s) 2Mg(s) + O 2 (g) 2MgO(s) Zn(s) Zn 2+ (aq) + 2e +) Cu 2+ (aq)

More information

福岡大学人文論叢47-3

福岡大学人文論叢47-3 679 pp. 1 680 2 681 pp. 3 682 4 683 5 684 pp. 6 685 7 686 8 687 9 688 pp. b 10 689 11 690 12 691 13 692 pp. 14 693 15 694 a b 16 695 a b 17 696 a 18 697 B 19 698 A B B B A B B A A 20 699 pp. 21 700 pp.

More information

研究成果報告書

研究成果報告書 500μm Before ATP After 10 Sikora J, Orlov SN, Furuya K, and Grygorczyk R (2015) Hemolysis is a primary and physiologically relevant ATP release mechanism in human. Blood 125: 1845 (Response to a letter)

More information

tary adenylate cyclase activating polypeptide ; PA-

tary adenylate cyclase activating polypeptide ; PA- Conformation of a peptide ligand bound to its G-protein coupled receptor and its implication for ligand transportation tary adenylate cyclase activating polypeptide ; PA- molecular biology (ed. Rich,

More information

444 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. +*,..../. (,**2) 12 Present State and Issues of Rice Powder Utilization : Rice Bread Koh-ichi Yo

444 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. +*,..../. (,**2) 12 Present State and Issues of Rice Powder Utilization : Rice Bread Koh-ichi Yo 444 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. +*,..../. (,**2) 12 Present State and Issues of Rice Powder Utilization : Rice Bread Koh-ichi Yoza, Mayuko Okabe and Jun Shima National Food Research

More information

Microsoft Word - プログラム詳細.doc

Microsoft Word - プログラム詳細.doc SL1 Nanobiology at UCLA and the CNSI Using Nanoparticle Design to Study Biocompatability and Material Toxicity André Nel, MD, PhD Division of NanoMedicine, Department of Medicine and the California NanoSystems

More information

研究成果報告書

研究成果報告書 X-SCID T NK Omenn T T 2007 2008 0menn T 1. 研究開始当初の背景 T T T T reversion T T 2. 研究の目的 RAG1/RAG2 Artemis T TCR T TCR 3. 研究の方法 RAG1/RAG2 μ μ μ μ μ μμ μμ μ 解析ダイアグラム 3-D display による TCR 多様性の評価 4. 研究成果 TCR T

More information

sigmusdemo.dvi

sigmusdemo.dvi V IT Demonstrations: Introduction of Research by Young Researchers V Masatoshi Hamanaka Akira Nishimura Hiroshi Takaesu Shigeyuki Hirai Katsutoshi Itoyama Akiyuki Yoshino Shohei Kajiwara Nozomi Kigimoto

More information

drug development Toshimi Michigami, E-mail : michigami@mch.pref.osaka.jp Keiichi Ozono, E-mail : keioz@ped.med.osaka-u.ac.jp The progress in the research on vitamin D 1) McCollum, E. V. et al.:

More information

The Heart Healthy Tocotrienol Complex Tocomin SupraBio

The Heart Healthy Tocotrienol Complex Tocomin SupraBio The Heart Healthy Tocotrienol Complex Tocomin SupraBio The Heart Healthy Tocotrienol Complex Tocomin SupraBio 1. Fact Sheet No. 317; World Health Organization (WHO), 2007 2. LLOYD-JONES D. et al. Circulation

More information

[Department of Pediatrics, Gifu University School Clinical. Pathological and Biochemical Abnormality in peroxisomal Disorders 1) Goldfischer, S., Moore, C. L., Johnson, A. B., Spiro, A. J., Valsamis,

More information

取扱説明書 [F-02F]

取扱説明書 [F-02F] F-02F 4. 2 3 4 5 6 7 8 9 0 2 3 4 5 6 7 8 a b c d a b c d a b cd 9 e a b c d e 20 2 22 ab a b 23 a b 24 c d e 25 26 o a b c p q r s t u v w d h i j k l e f g d m n a b c d e f g h i j k l m n x 27 o

More information

1) Y. Hatefi: Annu. Rev. Biochem., 54, 1015 (1985). 2) H. Weiss, T. Friedrich, G. Hofhaus & D. Preis: Eur. 4) M. Yamaguchi & Y. Hatefi: Biochemistry, 32, 1935 (1993). 5) K. Leonard, H. Haiker & H. Weiss:

More information

星医会00表紙.pdf

星医会00表紙.pdf H A,, , ,,, Facebook PSP PSP in situ hybridization New York Bronx Veterans Administration Hospital, Alcohol Research and Treatment Center demanding education e-ducare S. M. McCann Proc. Natl. Acad.

More information

Juntendo Medical Journal

Juntendo Medical Journal The hair growth effect of minoxidil Susumu OTOMO, Ph. D. Key words : minoxidil, minoxidil sulfate, hair growth, K+-channel opener, male pattern baldness Dept. of Pharmacology, Research Center Taisho Pharmaceutical

More information

 

  炎症の慢性化機構の解明と制御に向けた基盤技術の創出 平成 22 年度採択研究代表者 H25 年度 実績報告 清野宏 東京大学医科学研究所 教授 炎症性腸疾患の慢性化制御機構の解明と治療戦略の基盤構築 1. 研究実施体制 (1) 清野 グループ 1 研究代表者 : 清野宏 ( 東京大学医科学研究所 教授 ) 2 研究項目 炎症性腸疾患の慢性化制御機構の解明と治療戦略の基盤構築 (2) 高橋 グループ

More information

Bio-No.57/3....

Bio-No.57/3.... 2004. MAR. 3No.57 http://www.wako-chem.co.jp C O N T E N T S 2 Wako Bio Window No.57 MAR.2004 l l l l wako wako l l mmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmm Wako Bio Window No.57 MAR.2004 3 4 Wako Bio Window

More information

本文/YA7261E

本文/YA7261E J. Cell Biol.,,. Segev, N.Curr. Opin. Cell Biol.,,. Lafont, F., Lecat, S., Verkade, P., & Simons, K.J. Cell Biol.,,. Mostov, K.E., Verges, M., & Altschuler, Y.Curr. Opin. Cell Biol.,,. Sato, T., Mushiake,

More information

4) H. Takayama et al.: J. Med. Chem., 45, 1949 (2002). 5) H. Takayama et al.: J. Am. Chem. Soc., 112, 8635 (2000). 6) H. Takayama et al.: Tetrahedron Lett., 42, 2995 (2001). 9) M. Kitajima et al: Chem.

More information

Kazumitsu Ueda, [Department of Applied Life Science, Kyoto University Graduate School of Agriculture, Kitashirakawa, Sakyo-ku, Kyoto 606-01, Japan] Molecular Mechanisms for Drug Transport by MDR1/P-glycoprotein

More information

Review Column 1) Extavour, C. G., Akam, M. : Development, 130, 5869-5884 (2003) 2) Saitou, M. et al.: Philos. Trans. R. Soc. Lond. B. Biol. Sci., 358,1363-1370(2003) 3) Eddy, E. M. : Int. Rev.

More information

36 th IChO : - 3 ( ) , G O O D L U C K final 1

36 th IChO : - 3 ( ) , G O O D L U C K final 1 36 th ICh - - 5 - - : - 3 ( ) - 169 - -, - - - - - - - G D L U C K final 1 1 1.01 2 e 4.00 3 Li 6.94 4 Be 9.01 5 B 10.81 6 C 12.01 7 N 14.01 8 16.00 9 F 19.00 10 Ne 20.18 11 Na 22.99 12 Mg 24.31 Periodic

More information

431 a s a s a s d a s a 10 d s 11 f a 12 g s 13 a 14 a 15

431 a s a s a s d a s a 10 d s 11 f a 12 g s 13 a 14 a 15 431 a s a s a s d a sa 10ds 11fa 12gs 13a 14a 15 a s d f g h a s d 10f 11g a 12h s 13j a 14k s 15 432 433 10 11 12 13 14 15 10 11 12 13 14 15 434 10 11 12 13 14 15 10 11 12 13 14 15 10 11 12 13 14 15 435

More information

研究成果報告書(基金分)

研究成果報告書(基金分) (1) 種類 程度 肥満細胞数の測定と組織でのサ RT-PCR FACS () (1) NMU-/- IgE NMU IgE -/-NMU -/-B IgE NMU -/-B6 IgE NMU NMU CTLMC BMMC IgE NMU CTLMC 13 1. Hayakawa J, Mizukawa Y, Kurata M, Shiohara T: A syringotropic variant

More information

Correlation between molecular evolution of P450s and evolution of plant secondary metabolism Masaharu Mizutani E-mail : mizutani@scl.kyoto-u.ac.jp URL : http://biofun.kuicr.kyoto-u.ac.jp/index-j.html 13)

More information

Taro13-第6章(まとめ).PDF

Taro13-第6章(まとめ).PDF % % % % % % % % 31 NO 1 52,422 10,431 19.9 10,431 19.9 1,380 2.6 1,039 2.0 33,859 64.6 5,713 10.9 2 8,292 1,591 19.2 1,591 19.2 1,827 22.0 1,782 21.5 1,431 17.3 1,661 20.0 3 1,948 1,541 79.1 1,541 79.1

More information

33312004_先端融合開発専攻_観音0314PDF用

33312004_先端融合開発専攻_観音0314PDF用 Advanced Course for Interdisciplinary Technology Development National Institute of Technology, Gifu College Advanced Course for Interdisciplinary Technology Development 1 5 Curriculum National Institute

More information

3 6 6 8 5 5 0 4 3 4 4 0,000 3 ID ID ID 4 7 9 :5 4 5 60-8048 NACOS TEL: 075-45-366 FAX: 075-45-366 E-mail: jiao@nacos.com 3. Power Point PC 0 5. Power Point PC 7 3 3. 3 5 PC PC PC Windows Power Point USB

More information

第84回日本遺伝学会-抄録集.indd

第84回日本遺伝学会-抄録集.indd A S1 9 24 14 00 17 00 Epigenomic regulation of cell fate determination and homeostasis Organizers: (National Institute of GeneticsKyushu University 14 00 S1-1 1 RIKEN BioResource Center 2 Graduate School

More information

…O…›…fi…V…b…v›ï‘ê.Qx

…O…›…fi…V…b…v›ï‘ê.Qx 900 915 90 945 1000 1015 100 1045 1100 1115 110 1145 1,2 2 2 1 2 Department of Anatomy and Histology, University of Sydeney 1 2 1 2 2 1 1 1 2 NIDCR, NIH, USA 1 1 2 2 2 1 1 2 NIDCRNIHUSA 1 2 1 1 University

More information

jw_pant201406

jw_pant201406 6 7 8 6 7 8 9 0 Total Gym ₁ Project Walk Spinal Cord Injury Recovery, Department of Research and Development, Carlsbad, CA, USA; ₂ Department of Neurology, University of California, Irvine, CA, USA and

More information

0.02ml IgE RAST MAST CAP 2

0.02ml IgE RAST MAST CAP 2 ( ) 1 0.02ml IgE RAST MAST CAP 2 3 1963 30 4 1986 20 39 IgE 30% 1988 54.7% IgE 47.6% 1990 892 IgE 27% 12% 1995 2379 1995 8 15 1996 1 12 2335 98.5% 2335 24 61 47 44.0 1 1) 2335 613 26.3% 2 5 613 43.4 44.2

More information

大 気 海 洋 研 究 所 創 立 50 年 を 迎 えて

大 気 海 洋 研 究 所 創 立 50 年 を 迎 えて 大 気 海 洋 研 究 所 創 立 50 年 を 迎 えて 大 気 海 洋 研 究 所 創 立 50 年 を 迎 えて 0 1 0 2 0 2 1 0 2 2 0 2 3 0 3 0 3 1 0 3 2 0 3 3 0 4 0 4 1 0 4 2 0 4 3 0 5 Part 1 ATMOSPHERE AND OCEAN RESEARCH

More information

Stress-responsive MAP kinases 15) Lu, H. T., Yang, D. D., Wysk, M., Gatti, E., Mellman, I., Davis, R. J., Flavell, R. A. : EMBO J., 18,1845-1857 (1999) 16) Lu, B., Yu, H., Chow, C., Li, B., Zheng,

More information

本文/YA1300B

本文/YA1300B pp. T T B T T T NKT T Ig B BCR T TCR Generation of T-lineage cells and their functions Kazunori Onoé Division of Immunobiology, Department of Pathophysiology, Institute for Genetic Medicine, Hokkaido University,

More information

64) M.L. Gefter, R.L. Russell: J. Mol. Biol., 39, 145 (1969) 65) F. Harada, F. Kimura and S. Nishimura: Biochim. Biophys. Acta., 182, 590 (1969) 65a) F.H.C. Crick: J. Mol, Biol., 19, 548 (1966); M. Nirenberg

More information

ÿþ

ÿþ インターロイキン インターロイキンは リンパ球や単球 マクロファージなどの免疫反応への寄与が知られる白血球から産生されることから 細胞間 ( inter-) 白血球 ( leukocyte -leukin) より Interleukin と名づけられました 現在までに 30 種類以上のインターロイキンが同定され 発見された順番に番号が付与されており 中にはケモカイン ( IL-8) やインターフェロン

More information

C79 A11 A12 A13 A19 B11 B12 B13 B14 B15 B19 B21 B22 B23 B24 B25 C11 C12 C19 C21 C31 C32 C33 C34 C35 C36 C37 C39 C41 C51 C52 C53 C54 C55 C61 ( ) C62 C6

C79 A11 A12 A13 A19 B11 B12 B13 B14 B15 B19 B21 B22 B23 B24 B25 C11 C12 C19 C21 C31 C32 C33 C34 C35 C36 C37 C39 C41 C51 C52 C53 C54 C55 C61 ( ) C62 C6 C79 A11 A12 A13 A19 B11 B12 B13 B14 B15 B19 B21 B22 B23 B24 B25 C11 C12 C19 C21 C31 C32 C33 C34 C35 C36 C37 C39 C41 C51 C52 C53 C54 C55 C61 ( ) C62 C63 C64 C71 C72 C73 C74 C99 1 A11 A12 A13 A19 B11 B12

More information

CAR-T実施

CAR-T実施 Building a Clinical CAR-T Program - Jichi Medical University Experience l l l Anti-CD3/28 mabs & IL-2: 29% Anti-CD3/28 beads: 66% Retroviral: 41% Lentiviral: 54% T-Flasks: 22% Static Culture Bags: 35%

More information

高校生の就職への数学II

高校生の就職への数学II II O Tped b L A TEX ε . II. 3. 4. 5. http://www.ocn.ne.jp/ oboetene/plan/ 7 9 i .......................................................................................... 3..3...............................

More information

JR東日本会社要覧2012-2013

JR東日本会社要覧2012-2013 Technology Planning Department Frontier Service Development Laboratory Advanced Railway System Development Center Safety Research Laboratory Disaster Prevention Research Laboratory Technical Center Environmental

More information

untitled

untitled The 42 nd Annual Meeting of Japan Brain Science society 42 2015 111213 42 1. 2. 3. 4. 5. 1. 2. 3. 4. 10 http://www.anahirmiyazaki.com/ 10 269 220 ANA 2 2 1000 1016 930 946 1110 1126 1040 1056 1340 1356

More information

2

2 1999 No. 5 CHAPERONE NEWSLETTER CONTENTS 2 3 4 JEM JEM JEM, SEC, SCJ JEM JEM SCJ jem, scj 5 in vitro S. cerevisiae 6 K 7 in vitro Cell Mol. Cell in vitro 8 9 E. coli E. coli 10 in vitro ssc - b 11 in vivo

More information

本文/YA9255F

本文/YA9255F pp. ATP ε ATP ATP ATP ε Bacillus PS ATP ATP H H µ H ATP ATP ADP µ H ATP FoF -ATP FoF -ATP µ H H ADP ATP H Na On the regulatory role of the epsilon subunit in ATP synthase Yasuyuki Kato-Yamada Department

More information

プラズマ・核融合学会

プラズマ・核融合学会 1. Philosophy of Radiological Protection and Radiation Hazard Protection Law 1) Oita University of Nursing and Health Sciences, Oita, OITA 870-1201, Japan 2) National Institute for Fusion Science, Toki,

More information

CRA3689A

CRA3689A AVIC-DRZ90 AVIC-DRZ80 2 3 4 5 66 7 88 9 10 10 10 11 12 13 14 15 1 1 0 OPEN ANGLE REMOTE WIDE SET UP AVIC-DRZ90 SOURCE OFF AV CONTROL MIC 2 16 17 1 2 0 0 1 AVIC-DRZ90 2 3 4 OPEN ANGLE REMOTE SOURCE OFF

More information

4

4 4 r r 43 44 a b c f d e a r b c d e f 45 r r r 46 47 a b g a b r c d e f r g c d e f e 48 mm r r 1 49 a r b c a b 1 1 a 3 a 50 1 a 3 1 mb a 1 mm 3 a a a 51 1 mm 1 mm 1 5 mb 3 4 1 3 4 1 53 1 1 mj r 1 a

More information

J Life Sci Res 2014; 12: Osaka Prefecture University Journal of Life Science Research Online ISSN

J Life Sci Res 2014; 12: Osaka Prefecture University Journal of Life Science Research Online ISSN J Life Sci Res 2014; 12: 15-19 2014 Osaka Prefecture University Journal of Life Science Research Online ISSN 2186-5809 583-8555 3-7-30 577-8567 3-1-1 2014 9 11 2014 10 21 Exposure mild-level LED light

More information

1

1 I II II 1 dw = pd = 0 1 U = Q (4.10) 1K (heat capacity) (mole heat capacity) ( dq / d ) = ( du d C = / ) (4.11) du = C d U = C d (4.1) 1 1 du = dq + dw dw = pd dq = du + pd (4.13) p dq = d( U + p ) p (4.14)

More information

CONTENS

CONTENS Center for Innovation Kanazawa University Vol.4 2011-10 CONTENS 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 1 2 3 4 5 6 7 8 9 10 11 12 13 25 26 27 28 29 1 2 3 4 5 6 7 8 9 10 11 12 13

More information

Database Center for Life Science Online Service Signal transduction of growth factor mediated by heparin heparan sulfate

Database Center for Life Science Online Service Signal transduction of growth factor mediated by heparin heparan sulfate Signal transduction of growth factor mediated by heparin heparan sulfate 1) Zhu. X.. Komiya, H., Chirino, A.. Faham. S.. Fox, G. M., Arakawa, T., Hsu, B.T., Rees, D. C.: Science. 251, 90-93 (1991)

More information

少子化の動向と出生率に関する研究サーベイ

少子化の動向と出生率に関する研究サーベイ ESRI Research Note No.17 March 2011 Economic and Social Research Institute Cabinet Office Tokyo, Japan ESRI Research Note ESRI 03-3581-0919 1 1 2 3 4 5 6 2 3 18 50 2005 6 1 7 12,482 8,734 70.0 50 2005

More information

空き容量一覧表(154kV以上)

空き容量一覧表(154kV以上) 1/3 A. 電気所 ( 発電所, 変電所, 配電塔 ) における変圧器の空き容量 覧 < 留意事項 > (1) 空容量は 安であり 系統接続の前には 接続検討のお申込みによる詳細検討が必要となります その結果 空容量が変更となる場合があります (2) 熱容量を考慮した空き容量を記載しております その他の要因 ( や系統安定度など ) で連系制約が発 する場合があります (3) 表 は 既に空容量がないため

More information

2011 Vol.53 No.3 Jpn J School Health Jpn J School Health Jpn J School Health Kagawa Nutrition University Jpn J School Health Kagawa Nutrition University Jpn J School Health Jpn J School Health Japan

More information

2/8 一次二次当該 42 AX 変圧器 なし 43 AY 変圧器 なし 44 BA 変圧器 なし 45 BB 変圧器 なし 46 BC 変圧器 なし

2/8 一次二次当該 42 AX 変圧器 なし 43 AY 変圧器 なし 44 BA 変圧器 なし 45 BB 変圧器 なし 46 BC 変圧器 なし 1/8 A. 電気所 ( 発電所, 変電所, 配電塔 ) における変圧器の空き容量一覧 < 留意事項 > (1) 空容量は目安であり 系統接続の前には 接続検討のお申込みによる詳細検討が必要となります その結果 空容量が変更となる場合があります (2) 特に記載のない限り 熱容量を考慮した空き容量を記載しております その他の要因 ( や系統安定度など ) で連系制約が発生する場合があります (3)

More information

Kazumitsu Ueda, E-mail : uedak@kais.kyoto-u.ac.jp http : //cseika-1, kais.kyoto-u.ac.j p Molecular mechanism of multidrug transporter MDR I : ABC in host-defense machinery 32P-ATP 1) Chen, C., Chin,

More information

Database Center for Life Science Online Service Chiharu Ueguchi, Molecular mechanism and biological function of t

Database Center for Life Science Online Service Chiharu Ueguchi,   Molecular mechanism and biological function of t Chiharu Ueguchi, E-mail : cueguchi@agr.nagoya-u.ac.jp Molecular mechanism and biological function of the cytokinin signal tansduction pathway 1) Miller, C. 0., Skoog, F., von Saltza, M. H., Strong,

More information

その他/SP03 栂尾 016‐026(4)Y◎

その他/SP03 栂尾 016‐026(4)Y◎ CLINICIAN 11 NO. 602 16 Chemical Exchange Saturation Transfer Forsen Hoffman Balaban Exchange Magnetization Transfer CEST agent -NH -OH CEST agent CEST agent 17 CLINICIAN 11 NO. 602 A B Z- CEST CLINICIAN

More information

本文/YA9255C

本文/YA9255C pp. E- -SH X in vitro in vivo -SH Structure-based drug development and medical biological application of cathepsin specific inhibitors Nobuhiko Katunuma Institute for Health Sciences, Tokushima Bunri University,Nishihamabouji,

More information

A (1) = 4 A( 1, 4) 1 A 4 () = tan A(0, 0) π A π

A (1) = 4 A( 1, 4) 1 A 4 () = tan A(0, 0) π A π 4 4.1 4.1.1 A = f() = f() = a f (a) = f() (a, f(a)) = f() (a, f(a)) f(a) = f 0 (a)( a) 4.1 (4, ) = f() = f () = 1 = f (4) = 1 4 4 (4, ) = 1 ( 4) 4 = 1 4 + 1 17 18 4 4.1 A (1) = 4 A( 1, 4) 1 A 4 () = tan

More information

NIBEN Frontier 24

NIBEN Frontier 24 Yoshino Oishi Hiroshi Miyake Yasuo Ijima Shigeo Suzuki Akira Takayama NIBEN Frontier 23 NIBEN Frontier 24 NIBEN Frontier 25 NIBEN Frontier 26 NIBEN Frontier 27 NIBEN Frontier 28 NIBEN Frontier 29 NIBEN

More information

D., Nicola, N. A., Hilton, D. J.: Nature, 387, 917-921 (1997) 12) Alexander, W. S. : Nat. Rev. Immunol., 2,410-416 (2002) 13) Chung, C. D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., Shuai, K. : Science,

More information

RX501NC_LTE Mobile Router取説.indb

RX501NC_LTE Mobile Router取説.indb 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 1 2 3 4 5 6 7 8 19 20 21 22 1 1 23 1 24 25 1 1 26 A 1 B C 27 D 1 E F 28 1 29 1 A A 30 31 2 A B C D E F 32 G 2 H A B C D 33 E 2 F 34 A B C D 2 E 35 2 A B C D 36

More information