FISH Medical Technology C UDCA Helicobacter pylori 1 2PEG Client Nakagawa Y, Yamane Y, Okanoue T, Tsukita S, Tsukita T. Outer dense fiber 2 is a wides

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1 A Medical View Lamivudine B YMDD motif B 2 HCV C IP- 10 MIP-1 MCP-1 C C IFN ribavirin C Current Therapy B C Therapeutic Research lamivudine Okuda T Nishimura M Nakao M Fujita Y RUNX1/AML1 a central player in hematopoiesis Int J Hematol

Therapeutic Research lamivudine Okuda T Nishimura M Nakao

2 FISH Medical Technology C UDCA Helicobacter pylori 1 2PEG Client Nakagawa Y, Yamane Y, Okanoue T, Tsukita S, Tsukita T. Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: its identification from isolated centrosomes. Mol Biol Cell. 12: , Orito E, Ichiba T, Sakugawa H, Sata M, Horiike N, Hino K, Okita K, Okanoue T, Iino S, Tanaka E, Suzuki K, Watanabe H, Hige S, Mizokami M. Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan. Hepatology. 34: , Sumida Y, Nakashia T, Yoh T, Kakisaka Y, Nakajima Y, Ishikawa H, Mitsuyoshi H, Okanoue T, Nakamura H, Yodoi J. Serum thioredoxin elucidates the significance of serum ferritin as a marker of oxidative stress in chronic liver diseases. Liver. 21: , Gozuacik D, Murakami Y, Saigo K, Chami M, Mugnier C, Lagorec D, Okanoue T, Urashima T, Brechot C, Paterlini-Brechot P. Identification of human cancer-related genes by naturally occurring hepatitis B virus DNA tagging. Oncogene. 20: , Itoh Y, Morita A, Nishioji K, Narumi S, Toyama T, Daimon Y, Nakamura H, Kirishima T, Okanoue T. Clinical significance of elevated serum interferon-inducible protein-10 levels in hepatitis C virus carriers with persistently nomal serum transaminase levels. J Viral Hepat. 8: , Itoh Y, Morita A, Nishioji K, Fujii H, Nakamura H, Kirishima T, Toyama T, Yamauchi N, Nagao Y, Narumi S, Okanoue T. Time course profile and cell-type-specific production of monokine induced by interferon in Concanavalin A-induced hepatic injury in mice: comprative study with interferoninducible protein-10. Scand J Gastroenterol. 36: , Yagita K, Iwai M, Yagita-Toguri M, Kimura H, Taniwaki M, Misawa S, Okanoue T, Kashima K, Tsuchihashi Y. Langerhans cell histiocytosis of an adult with tumors in liver and spleen. Hapato- Gastroenterol. 48: , Nakashima T, Yoh T, Sumida Y, Kakisaka Y, Mitsuyoshi N. Differences in the efficacy of ursodeoxycholic acid and bile acid metabolism between viral liver diseases and primary biliary cirrhosis. J Gastroent Hepatol. 16 (5) : , Tanaka H, Takamatsu T. Calcium spots. Elementary signals in response to mechanical stress in vascular endothelial cells. Circ Res. 88: , Inoguchi K, Hamaguchi H, Taniwaki M, Yamaguchi H, Tanosaki S, Dan k. Establishment of a cell line with AML-MTG8, TP53, and TP73 abnormalities from acute myelogenous leukemia. Gene Chromosomes Cancer. 32: , Otsuki T, Wada H, Nakazawa N, Taniwaki M, Kouguchi K, Ohkura M, Uehira K, Isoda K, Yata K, Sakaguchi H, Yawata Y, Ueki A, Yamada O. Establishment of CD7+human myeloma sister cell lines,

Orito E, Ichiba T, Sakugawa H, Sata M, Horiike N, Hino K, Okita K, Okanoue T, Iino S, Tanaka E, Suzuki K, Watanabe H, Hige S, Mizokami M.

3 KMS-21-PE and KMS-21-BM, carrying t (11; 14) and t (8; 14). Leuk Lymphoma. 42: , Kaneko H, Kita Y, Taniwaki M, Kashima K, Ohkawara Y. Cryptococcal meningitis in a patient with chronic adult T-cell leukemia in complete remission. J Jpn Association. 75: , Kaneko H, Kita Y, Taniwaki M, Kashima K, Ohkawara Y. Clinicopathologic and cytogenetic analyses of three cases of primary uterine Non-Hodgikin's lymphoma. Intern Med. 40: , Kita Y, Horiike S, Misawa S, Kaneko H, Kobayashi M, Nakao M, Nakagawa H, Fujii H, Taniwaki M. International prognostic scoring system and TP53 mutations are independent prognostic indicators for patients with myelodysplastic syndrome. Br J Haematol. 115: , Tatsumi K, Taki T, Taniwaki M, Nakamura H, Taguchi J, Chen Y Z, Bessho F, Yanagisawa M, Hayashi Y. The CDCRELI gene fused to MLL in de nove acute myeloid leukemia with t (11; 22) (q23; q11. 2) and its frequent expression in myeloid leukemia cell line. Gene Chromosomes Cancer 30: , Hatzivassillou G, Miller I, Takizawa J, Palanisamy N, Rao P H, Lida S, Tagawa S, Taniwaki M, Russo J, Neri A, Cattoretti G, Clynes R, Mendelsohn C, Chaganti R S K, Dalla-favera R. IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. Immunity. 14: , Hanamura I, Iida S, Akano Y, Hayami Y, Kato M, Miura k, Harada S, Banno S, Wakita A, Kiyoi H, Naoe T, Shimizu S, Nitta M, Taniwaki M, Ueda R. Ectopic expression of MAFB gene in human myeloma cells carrying (14; 20) (q32; q11) chromosomal translocations. Jpn J Cancer Res. 92: , Fujita Y, Nishimura M, Taniwaki M, Abe T, Okuda T. Identification of an alternatively spliced form of the mouse AML1/RUNX1 gene transcript AML1c, and its expression in early hematopoietic development. Biochem Bioph Res Co. 281: , Yagasaki F, Wakao D, Yokoyama Y, Uchida Y, Murohashi I, Kayano H, Taniwaki M, Matsuda A, Bessho M. Fusion of ETV6 fibroblast growth factor receptor 3 in peripheral T-Cell lymphoma with a t (4; 12) (p16; p13) chromosomal translocation. Cancer Res. 61: , Orito E, Mizokami M, Sakugawa H, Michitaka K, Ishikawa K, Ichiba T, Okanoue T, Yotsuyanagi H, Iino S. A-case control study for clinical and molecular biological differences between hepatitis B viruses of genotype B and C. Hepatology. 33: , Nishioji K, Okanoue T, Itoh Y, Narumi S, Sakamoto M, Nakamura H, Morita A, Kashima K. Increase of chemokine interferon-inducible protein-10 (IP-10) in the serum of patients with autoimmune liver diseases and increase of its mrna expression in hepatocytes. Clin Exp Immunol. 123: , Okanoue T, Daimon Y, Kirishima T, Ohnishi N, Nakamura H, Nagao Y, Minami M, Itoh Y. Retreatment with interferon- at dosages or period increased by 1. 3 times is effective for treatment for transient responders and non-responders in chronic hepatitis C patients. Hepatol Res. 20: , Tanaka H, Habuchi Y, Suto F, Morikawa J. Effects of hydrogen peroxide on the transient outward current in rabbit atrial myocytes. Clin Exp Pharmacol Physiol. 28: , Gastroenterol Endosc small lymphocytic lymphoma/ chronic lymphoma leukemia Add (12p) double Ph ERCP

Clinicopathologic and cytogenetic analyses of three cases of primary uterine Non-Hodgikin's lymphoma. Intern Med. 40: 1028-1031, 2001.

4 C C GM Pharma Medica S2 C S2 G-1 DDW Japan QT dispersion 4 DDW Japan cyclin D1 DDW Japan

5 ERCP The effects of intravenous and intramuscular high dose interferon therapy on hepatitis C virus dynamics Serum thioredoxin levels as an indicater of oxidative stress in patients with hepatitis C virus infection Biloma Abscess JTE-907 Tanaka H, Tsujii E, Oyamada M, Takamatsu T. Excitation-coupled calcium waves at the border zone of cryo-injured rat heart revealed by in situ real-time confocal microscopy. 74th Annual Scientific Sessions, American Heart Association, Anaheim CA, USA, Circulation Suppl. 2 B Japan Medicine C Japan Medicine Japan Medicine Japan Medicine C Imai H, Kasahara A, Okanoue T, Tsubouchi H, Kawata S, Tamura S, Yoshioka K, Kiyosawa K, Kakumu S, Okita K, Hayashi N. Effect of interferon therapy on the risk of the hepatocellular carcinoma and mortality in patients with chronic hepatitis C: A large retrospective cohort study of 3296 patients. 52th Annual Meeting of the American Association for the Study of Liver Disease ; Dallas, USA. Okanoue T, Itoh Y, Sakamoto M, Kirishima T, Daimon Y, Toyama T, Morita A, Nakajima T, Minami M. Transient biochemical response in interferon thrapy decreases the development of hepatocellular carcinoma for five years and improved the long-term survival of chronic hepatitis C patients. 53th Annual Meeting of the American Association for the Study of Liver Disease (AASLD) ; Dallas, USA. Ohnishi N, Itoh Y, Yamaguchi K, Okanoue T, Itoh K, Fujita J. Efficient expression of transduced genes by a novel hybrid retrovirus vector in hepatocytes are regulated by two elements in the upstream control region on the SFFVp LTR. 53th Annual Meeting of the American Association for the study of Liver Disease AASLD ; Dallas, USA.

Excitation-coupled calcium waves at the border zone of cryo-injured rat heart revealed by in situ real-time confocal microscopy.

6 Minami M, Kirishima T, Daimon Y, Mori Y, Itoh Y, Okanoue T. A Novel sensitive method for the detection of lamivudine-resistant HBV mutants using peptide nucleic acids-mediated PCR clamping and restriction fragment length polymorphism. 53th Annual Meeting of the American Association for the study of Liver Disease (AASLD) ; Dallas, USA. Imai Y, Kasahara A, Okanoue T, Tsubouchi H, Kawata S, Tamura S, Yoshioka K, kiyosawa K, Kakumu S, Okita K, Hayashi N. Effect of interferon therapy on the risk of hepatocellular carcinoma and mortality in patients with chronic hepatitis C: a large retrospective cohort study of 3296 patients. 53th Annual Meeting of the American Association for the study of Liver Disease (AASLD) ; Dallas, USA. Tanaka H, Tsujii E, Oyamada M, Takamatsu T. Abnormal intracellular calcium handlings at the epicardial border zone of the cryo-injured rat heart revealed by real-time confocal microscopy. International Symposium; Cardiac function-osaka ; Osaka. Noda M, TakamaT, Morgan D, Poulsom R, Tatsumi Y, Mitsufuji S, Sugihara H, Cox H. Wright N, Hattori T. A possible mechanism of gastric carcinoma dedifferentiation, regulation of the e-cadherincatenin complex by intestinal trefoil factor. 4th international Gastric Cancer congress ; New York. T Yoh, T Nakashima, Y Sumida, Y Kakisaka, H Ishikawa, H Mitsuyoshi, T Okanoue. Glycyrrhizin effects rat hepatocytes via the reduction of heat shock portein 90 expression. Digestive Disease Week ; Georgia World Congress Center, Atlanta, Georgia, USA. Y Sumida, T Nakashima, T Yoh, Y Kakisaka, H Mitsuyoshi, T Okanoue, H Nakamura, J Yodoi. Independent predictors of hepatic steatosis and fibrosis in Japanese patients with chronic hepatitis C. Digestive Disease Week ; Georgia World Congress Center, Atlanta, Georgia, USA. Kodama T, Sato H, Imamura Y, Koshitani T, Abe M, Kato K, Uehira H, Horii Y, Yamane Y, Kashima K. The Diagnosis of Chronic Pancreatitis with the electronic Pancreatoscope System. Digestive disease week ; Atlanta. T Nakashima, Y Sumida, T Yoh, Y Kakisaka, H Mitsuyoshi, T Okanoue, H Nakamura, J Yodoi. Serum thioredoxin levels as an indicator of oxidative stress in patients with nonalcoholic steatohepatitis. Research Forum: NASH-Pathogenesis. Digestive Disease Week ; Georgia World Congress Center, Atlanta, Georgia, USA. Fujita Y, Nishimura M, Taniwaki M,, Abe T, Okuda T. Identification of an alternative splice form of the mouse AML1/RUNX1 gene transcript AMLc, and its expression pattern in early hematopoietic development. Nomura K, Nakao M, Ueda K, Matsumoto Y, Yokota S, Horiike S, NIshida K, Nakamura S, Taniwaki M. Cytogenetic evidence for the development and transformation of follicular and mantle cell lymphoma by using fluorecence in site hybridization on paraffin-embedded tissue. 43rd Annual Meeting of The American Society of Hematology ; Orland, USA. Ono R, Taki T, Taketani t, Kawaguchi H, Taniwaki M, Okumura T, Kawa K, Hanada R, Kobayashi M, Hayashi Y. The SEPTING Is fused to the MLL gene in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24. 43rd Annual Meeting of The American Society of Hematology ; Orland, USA. Matsumoto Y, Nomura K, Ueda K, Akano Y, Fujita Y, Kakazu N, Nishida K, Okuda T, Taniwaki M. The immunoglobulin heavy chain gene translocation in Hodgkin and Reed-Sternberg cells detected by fluorescence in situ hybridization on paraffin-embedded tissue section. 43rd Annual Meeting of The American Society of Hematology ; Orland, USA. Taki T, Akano Y, Taniwaki M, Y. Z Chen, Soeda E, Fukushima T, Tsuchida M, Hayashi Y. Fusion of the OTT and MAL gene in infant acute magakaryoblastic leukemia with t (1; 22) (p13; q13). 43rd Annual Meeting of The American Society of Hematology ; Orland, USA.

53th Annual Meeting of the American Association for the study of Liver Disease (AASLD). 2001. 11. 10; Dallas, USA.

7 Nakao M, Horiike S, Fujita Y, Ueda K, Kashima K, Okuda T, Taniwaki M. Novel insertion mutation of the hematopoiesis-related Transcription factor, AML1/RUNX1, associated with myelodysplastic syndromes (MDS). 43rd Annual Meeting of The American Society of Hematology ; Orland, USA. Nishimura M, Fujita Y, Nakao M, Fukushima Y, Toda S, Kitamura N, Abe T, Okuda T. Genetically modified mouse line with a limited repertoire of the isoforms for leukemia-associated transcription factor. 43rd Annual Meeting of The American Society of Hematology ; Orland, USA. Hayami Y, Shinsuke Iida, Hanamura I, Kato M, Nakazawa N, Ishida T, Miura K, Ito M, Komatsu H, Wakita A, Miura I, Dave B. J, Sanger W. G, Taniwaki M, Ueda R. Inactivation of E3/LAPTM5 Gene by Either Chromosomal Rearrangement or Methylation at the First Intronic Sequences in Human Multiple Myeloma. 43rd Annual Meeting of The American Society of Hematology ; Orland, USA. EMR EMR Chemoprevention. Selective cyclooxy-genase-2 COX-2 Inhibitor Chemoprevention Endoscopic Day Surgery Endoscopic Day Surgery Endoscopic Day Surgery Endoscopic Day Surgery MALT Molecular cytogenetic diagnosis of MALT lymphoma 2 C HPA-axis

2001. 12. 9; Orland, USA. Nishimura M, Fujita Y, Nakao M, Fukushima Y, Toda S, Kitamura N, Abe T, Okuda T.

8 HCC EBV Cytoprotection MALToma Tanaka H, Tsujii E, Habuchi Y, Morikawa J. Arrhythmogenic intracellular calcium dynamics at the border zone of cryo-injured rat heart revealed by real-time confocal microscopy. Featured Research Session, 65 th Annual Scientific Meeting of the Japanse Circulation Society trientine B FISH Spectral Karyotyping SKY HSP90 p36 q32 sorter-fish IgH masked type APL MN1-TEL PASG TCR-delta

9 AML1 RUNX1 Musashi-1 Msi-1 sm AML1 AML1 RUNX1 Myeloid/NK precursor Hanamura I Iida S Akano Y Kiyoi H NAoe T Shimizu S Taniwaki M Ueda R Altered expression on MAFB gene in human myeloma cells carring (14 20) chromosomal translocation Kaneko H Kita Y Ohkawara Y Taniwaki M Kashima K Sonoda Y Autologous peripheral blood stem cell transplantation for high-risk or relapsed non-hodgkin lymphoma Helicobacter Pylori HP HP q32 q11 MAFB Serrated Adenoma Catenin EIS APC C C

Kaneko H Kita Y Ohkawara Y Taniwaki M Kashima K Sonoda Y Autologous peripheral blood stem cell transplantation for

10 C ERCP C ESR ESR JTE-907 AML1/RUNX1 C UDCA t q22 q23 AML MLL AF10q22 Billoma Abscess HCV ERCP EBM TIPS

11 gastrointestinal stromal tumor GIST p34 q32 IgH B Target cytogenetics IgH AML1/RUNX1 UDCA DDW-Japan 2001 NUD non-ulcer dyspepsia Musahi-1 IEC-6 Helicobacter pylori HP HP ConA TNF IFNPPAR -RXR

12 C DDW-Japan G-1 cyclin D1 EIS EVL SSL EIS Helicobacter pylori HPA axis t (X 11) (q24 q23 MLL FISH t (14 18) de novo CD5 B CML Ph AML M2 TCR/Ig ALL MRD p13 q13 OTT-MAL

13 Bartram CR TCR- VJ Castleman's disease Hodgikin's lymphoma mixed cellularity PSC NASH C HCV vanishing bile duct syndrome YMDD motif mutant B AFP Caroli AP CTRL-1 homologue QTD

14 GERD B T Proton magnetic resonance assay of total and taurine-conjugated bile acids in bile PCR MRD ALL G-CSF sweet MDS Mini Transplant TOY SOL CML IFN SKY target cytogenetics PEG SKY FISH IGH CDL

15 Cannabinoid Agonist JTE-907 Castleman mixed cellularity ERCP EBM CD20 C C IFN Gleevec CML auto-pbsct NK NO Interphase detection of immunogloblin heavy chain gene translocation with specific oncogene loci in 173 patients with B-cell lymphoma GM Chemical agent ENNG Helicobacter HP SOL Forum Helicobacter Pylori HP HP

gene translocation with specific oncogene loci in 173 patients with B-cell

16 sm HPA-axis responses during experimental colitis in the rat

研究成果報告書

研究成果報告書系レニン 1. Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Shimokawa H, Kohzuki M. Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure.