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1 OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE FACULTY OF MEDICINE 2016 OUTLINE

2 From rote learning to communication Inheriting the free and open academic character and fundamental forward-looking spirit of its predecessor Tekijuku, founded in Osaka by OGATA Koan, the Graduate School of Medicine/Faculty of Medicine, Osaka University has contributed to society and to the development of medicine in Japan and around the world, while also undergoing a number of changes in name. In the future as well, it will continue to play a leading role in world medicine as it ceaselessly communicates information on new medical science OGATA Koan founds Tekijuku as a facility for medical education 1849 OGATA Koan founds Jotokan as a facility for technical education of Western-style doctors 1868 The Meiji Emperor orders the construction of a hospital at the Osaka court of law 1869 Osaka Provisional Hospital opened Headed by OGATA Koreyoshi and the Western doctor Anthonius Franciscus Bauduin 1870 Jotokan merged with the Osaka School of Medicine (to become Shutokan, the School s affiliated vaccination center) 1879 Osaka Public Hospital opened in Nakanoshima 1993 Osaka University Hospital was moved from Nakanoshima, Osaka to the Suita campus. OGATA Koan Tekijuku Historical landmark & important cultural asset Jotokan OGATA Koan was revered during the closing days of the Tokugawa Shogunate as a leading Western-style doctor and educator on Western science through the Dutch language. Together with translating numerous Western works into English in order to introduce the latest medical knowledge to Japan, he also authored a number of works himself. Of these, the publication of his translation of Enchiridion medicum, or, the practice of medicine (30 volumes) was his life s work. This was a secondhand translation into Japanese of the Dutch translation of German doctor Christoph Wilhelm Hufeland s summation of his 50 years of experience as a physician. It contributed greatly to the advancement of internal medicine in Japan. Tekijuku was a school of Western science through the Dutch language founded in Osaka in 1838 by OGATA Koan. While teaching advanced Western subjects such as medicine and pathology, it also strived to promote and improve medicine through means including publishing guidelines for treatment of infectious diseases such as cholera, which was prevalent at the time. Students who studied under Koan, who was both a doctor and an outstanding educator, later served as a driving force behind Japan s modernization during the Meiji Period. Tekijuku graduated numerous exceptional talents including NAGAYO Sensai and FUKUZAWA Yukichi. Koan established this facility together with doctors HINO Katsumin and YAMATOYA Kihei, among others, in Osaka s Doshomachi in 1849, when smallpox was introduced to Japan, as a base for promoting natural prevention of smallpox. Use in Japan of the cowpox vaccine, developed in 1796 by the English doctor Edward Jenner, began at this facility (renamed Shutokan in 1870).

3 INDEX 06 Prize 08 Initiatives 10 Message from the Dean The origins of the Graduate School of Medicine/Faculty of Medicine, Osaka University can be traced back to Tekijuku, founded in Osaka in 1838 by OGATA Koan. Stepping forward to promote smallpox vaccination in order to control the disease, which was prevalent at the time, OGATA dedicated his life to the introduction of Western medicine in Japan. Inheriting this spirit from Koan, today we educate new medical professionals and promote advances in basic medicine to support the medicine of the future, based on the keywords of Innovation, Translation, and Globalization. For these purposes, we have developed three initiatives as comprehensive, cross-functional organizations extending from the Faculty of Medicine to the University Hospital as well as other affiliated sections and other institutions. These are the Global Health Initiative, intended to promote international exchange, the Industry-Academy Cross-Innovation Initiative to promote industry-academy alliances, and the Bio-informatics Initiative aiming to develop clinical applications of big data in human genome analysis research. We also are carrying out educational reforms in Faculty of Medicine education as well as our master s and doctoral degree programs, intended to teach Professionalism and Globalism. In research, we are advancing new developments in cooperation with the University Hospital to link advanced medical knowledge discovered and developed at Osaka University to new innovations, and in the future as well we plan to put to use the considerable results that we have achieved as one of Japan s leading institutions to promote advanced medicine through translational research. To expand into the world and play an active role in the local community over the coming 50 to 100 years, while also respecting the efforts of our predecessors and traditional culture, we will strive for the further progress of the Graduate School of Medicine/Faculty of Medicine, Osaka University as a Challenging, Sustainable, and Tough institution with a free and broad-minded culture focused on practical applications and the forward-looking ability to envision the future. Number of Staff and Students 12 Support for Studying Abroad / in Osaka 14 Medical Education 16 Overview 24 Institutions 28 Accounting / Systematical Anatomy / Press release 30 History

4 Prize International Prize Domestic Prize Japan Prize 2 Tadamitsu KISHIMOTO / Toshio HIRANO <Year 2011> 2 Gairdner Prize Shizuo AKIRA Year 2011> 1 Wolf Prize Osamu HAYAISHI Year 1986> Crafood Prize 2 Tadamitsu KISHIMOTO / Toshio HIRANO <Year 2009> Shimon SAKAGUCHI <Year 2015> Robert Koch Award 5 Tadatsugu TANIGUCHI Year 1991> Shigekazu NAGATA <Year 1995> Shizuo AKIRA Year 2004> Tasuku HONJO <Year 2012> Robert Koch Gold Medal Tadamitsu KISHIMOTO Year 2003>

5 Initiative = Global Health Initiative = = Strategic Global Partnership & Cross-Innovation Initiative = = Bioinformatics Initiative =

6 Number of Staff and Students Full-Time Staff (Medical School) 708 Undergraduate Students (Medical School) 674 Graduate Students (Medicine / Medical Sciences) 849 Part-Time Staff (Medical School) 492 Full-Time Staff (Allied Health Sciences ) 98 Undergraduate Students (Allied Health Sciences ) 686 Graduate Students (Health Sciences) 267 Part-Time Staff (Allied Health Sciences ) 41 Actual results of 2016 Entrance Examination (Undergraduate) Actual results of 2016 Entrance Examination (Graduate School) Undergraduates enrolled as non first year student Degrees Awarded Number of Main Chair Number of Joint Research Chair Number of Endowed Chair Affiliate Graduate School

7 Support for Studying Abroad / in Osaka Number of International Students Inter-Faculty Academic Exchange Agreement Medical School Allied Health Sciences

8 医学教 育システム Medical Education 受賞 医学部医学科 6年 Medical School, Undergraduate Program (6 years) 医 学 部 医 学 科では グローバルな視 点をもった医 師を養 成する目的で医 学 英 語 教 育を開 始し 海 外 留 学も推 奨しています M D 研 たに未 来 臨 床 科 学コースを開 設 また公 衆 衛 生 学コースの内 容も改 革し バイオインフォマティクス スポーツ医 学 医 学 統 計 医 学 st 1 2年 2 4年 3年 nd 3 rd 4 th 5年 5 6年 th 6th イ ニ シ ア ティ ブ 究 者 育 成プログラムにより 研 究マインドをもち将 来 基 礎 医 学の領 域で 活 躍できる医 師の養 成も行っています 修 士 課 程では 新 1年 医学英語 倫 理など キャリアパスの明 確な教 育を行います 修 士 課 程 修 了 時には修 士 医 科 学 または修 士 公 衆 衛 生 学 の学 位が 授 与さ Medical English れます 博 士 課 程では 世界の医学研究や医療の発 展に貢 献するリーダーと成り得る人材の養 成を行っています MD-研究者育成プログラム MD-Researcher Education Program In the Graduate School of Medicine, we offer undergraduate, master and doctoral degree programs. The undergradum.d. mended to have a shor t study-abroad experience. This program also includes a Medical Doc tor Scientist Program aimed at cultivating research mind to produce researchers equipped with abilit y to engage in ac tive basic research. The master program of fers new futuristic clinical courses and a reformed public health course in which students take cour ses such as bioinfor matic s, spor t s medicine, bios t atis tic s and medic al ethic s. All cour ses are designed to 教職員数 学生数 ate program focuses on training young students with a global perspective and during the program, students are recom- 基礎配属 基 共通教育 Liberal Arts Research e Program 基礎医学 学 Basic Medicine e 臨床医学 海外研修! Go Abroad! Clinical Clerkship h 国際交流 strengthen the capacity of our students and clarify their career paths. At the end of the master program, students will be awarded the degree of Master of Medical Science or Master of Public Health. In the doctor course, our educational program aims at producing graduates able to contribute to the development of basic and clinical research. 修士課程 2年 Master Course (2 years) 6 医科学コース Medical Science Course 博士課程医学専攻 M.D. 年 4 臨床研修 年 Residency 2-5 years Medicine Doctor course 4 years Ph.D. M.A. 未来臨床科学コース(2017年から) Clinical Science Course (from 2017) スポーツ医学 バイオインフォマティクスなど Master of Medical Science 概要 2-5 Medical School Undergraduate Program 6 years 年 医学教育 医学部医学科 Sport Medicine, Bioinformatics, Biomechanics 公衆衛生学コース Public Health Course 医学以外の学部 年 Non-medical universities 4 years B.A. 2 年 Master Course 2 years 公衆衛生学 医学統計* 医学倫理*など * 2017年から M. A. Public Health, Medical Statistics*, Medical Ethics* (*: from 2017) M.A. 死因究明学コース 学位 Degree 施設 4 修士課程 Master of Public Health Cause-of-death Investigation Course 医学英語教育 Medical English Training 財 務 系 統 解 剖 プレ ス リ リ ー ス 博士課程 4年 Doctor Course (4 years) Ph.D. 医学専攻 Medicine 年表 14 Doctor of Philosophy in Medical Science 15

9 Osaka University Graduate School of Medicine Faculty of Medicine Division of Medicine Overview Organization Faculty and Faculty Members

10 Endowed Chair Affiliate Graduate School Division of Medicine Affiliate Graduate School

11 Center and Institute Independent Associate Professor Endowed Chair Joint Research Chair

12 Division of Health Sciences Affiliate Graduate School Endowed Chair Joint Research Chair Center and Institute

13 Institutions 1 2 Icho kaikan The Center of Medical Innovation and Translational Research (CoMIT) This is an R&D facility based on industry-academy-government alliance aiming to develop advanced medical technologies and innovative new medicines through the fusing of research from across differing fields. The primary research fields of the CoMIT are immunology and regenerative medicine, in which Osaka University has played a leading role, and the integration of these two fields. This center aims to promote open innovation and accelerate industrialization of research results while deepening cooperation with diverse companies and institutions both on and off campus. 3 Osaka University Hospital First floor: Medical History Museum etc. Second floor: Igaku Shinko Ichokai, Osaka Eye Bank, Restaurant Minerva, Icho Club Third floor: Hankyu Corporation-Sanwa Bank Hall (capacity 250 persons), Large Meeting Room (capacity 68 persons), Meeting Room B (capacity 42 persons), Meeting Room C (capacity 36 persons), Small Meeting Room (capacity 7 persons) Consultation times: *First-time visitors to Osaka University Hospital must have a referral from a physician. First visit 8:30 am to 11:00 am Revisit 8:30 am to 11:30 am Revisit with appointment 8:30 am to 3:00 pm Non-consulation days: Saturdays, Sundays, Holidays New Year s Holidays: Dec. 29 to Jan. 3 Number of beds: 1,086 Guide for Visitors Department of Medicine Department of Surgery Department of Sensory, Cutaneous and Motor Organ Medicine Department of Clinical Neuroscience Department of Woman, Child Health and Urology Department of Radiology Unit of Dentistry Number of patient Total Number of Inpatients (Unit: person) Average Number of Inpatients Per Day (Unit: person) Total Number of Outpatients (UnitPerson) Cardiovascular Medicine/ Nephrology/ Gastroenterology and Hepatology/ Metabolic Medicine/ Respiratory Medicine/ Allergy and Rheumatic Diseases/ Hematology and Oncology/ Geriatrics and Hypertension/ Kampo Medicine Cardiovascular Surgery/ General Thoracic Surgery/ Gastroenterological Surgery/ Breast and Endocrine Surgery/ Pediatric Surgery/ Department of Diagnostic Pathology Ophthalmology/ Otorhinolaryngology-Head and Neck Surgery/ Orthopaedic Surgery/ Dermatology/ Plastic Surgery Rehabilitation Medicine Neurology and Cerebrovascular Diseases/ Neuropsychiatry Neurosurgery/ Anesthesiology Obstetrics & Gynecology/ Pediatrics/ Urology Diagnostic and Interventional Radiology/ Radiotherapy/ Nuclear Medicine Dentistry Average Number of Outpatients Per Day (Unit: person) 337, ,314 2,429.3

14 4 PET Molecular Imaging Center Equipped with a cyclotron, radiotracer synthesis equipment, a facility for raising animals, and animal Positron Emission Tomography (PET) cameras, this Center is capable of imaging of molecular behavior inside the living bodies of disease model animals and genetically modified animals and analyzing medical conditions at a molecular level. It also researches basic molecular imaging technologies such as those used in pharmacokinetics of candidate compounds in new drug development and pharmacometerics. Suita Campus N 5 Center for Medical Research and Education The Center for Medical Research and Education was established to support collaborative use of advanced equipment for life science. Technical staff persons in the center proactively provide technical support for research and student education. 6 Institute of Experimental Animal Sciences This Institute manages animal experimentation in compliance with international guidelines on use of lab animals. It supports advanced medical research in areas including generation of genetically modified animals through genome editing, breeding a wide range of disease model animals, and elucidation of the mechanism and development of the therapeutic strategy for intractable disieases Center for Twin Research This Center is the first research institution in Japan to specialize in twin research.partnering with leading twin research institutions in Japan and around the world, it aims to advance the field of preventive medicine-the paramount of medical research-through precise analyses of environmental factors.we conduct innovative research in multidisciplinary approaches,in collaboration with education, behavioral science, psychology, and social sciences. Tokyo Branch Center for communication and collection of information in the greater Tokyo area Meeting Room 911 (capacity 18 persons) / Meeting Room 912 (capacity 36 persons) Meeting Room 913 (capacity 54 persons) / Small Meeting Room (capacity 12 persons) *Note: A Joint Meeting Room with maximum capacity of 210 persons also is available (at a charge). Address: 9F, Nihonbashi Life Science Building, 3-11 Nihonbashihoncho 2-chome, Chuo-ku, Tokyo

15 Accounting Revenue Expenditure Grants in Aid for Scientific Research (KAKENHI) 9,444,058,216 9,345,335, ,664, ,278,478 Transition of the number of outside funds in five years Number of Cadavers Collected Number of Cadavers Used Systematical Anatomy Health Labour Sciences Research Grant Numbers of Patents Press release (FY 2015) Number of release 28 Number of newspaper serial 37 * Including the research-related indirect costs * Including the research-related indirect costs

16 History

17

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