化学療法剤の適切な使い方について
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2 5 6 7 Che E, in Cancer: Principles & Practice of Oncology (7th ed) in Devita, 2005 Marangolo M, Oncol Rep, 2006 hryniuk WM, Important Adv Oncol, Cancer: Principles & Practice of Oncology 5th Ed. Devita, 1997
3 9 Rassnick KM, Vet Comp Oncol, 2010 Vaughan A, JVIM, 2007 Frimberger AE, JVIM, IIIVn= 66 L-CHOP-CCNU-MOPP p= 0.05 L-CHOP Rassnick KM, Vet Comp Oncol, IIIVn= Vaughan A, JVIM, IIIVn= 28 VELCAP p= Frimberger AE, JVIM, 2006
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6 21 London CA, Vet Compar Oncol, n= 85 % n=32 n=23 n=15 n=8 n=7 London CA, Vet Compar Oncol, n= 85 London CA, Vet Compar Oncol,
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13 49 Rassnick KM, JAVMA, Dank G, Vet Comp Oncol, % 1. Moore AS, J Vet Intern Med. 1990, 2. Chun R, J Am Vet Med Assoc. 1996, 3. Knapp DW, Cancer Chemother Pharmacol. 2000, 4. Chun R, Vet Intern Med. 1997, 5. Knapp DW, J Vet Intern Med. 1994, 6. Mutsaers AJ, J Vet Intern Med. 2003, 7. Knapp DW, J Vet Intern Med. 2013, 9. Arnold EJ, J Vet Intern Med. 2011, 12. Robat C, J Small Anim Pract. 2013, 13. Mohammed SI, Cancer Res. 2002, 14. Mohammed SI, Mol Cancer Ther. 2003, 15. Boria PA, Vet Comp Oncol. 2005, 16. Greene SN, J Am Vet Med Assoc. 2007, 18. Marconato L, J Am Vet Med Assoc. 2011, 19. Kaye ME, Vet Comp Oncol. 2013, 20. Schrempp DR, J Am Vet Med Assoc. 2013, 21. Henry CJ, Clin Cancer Res. 2003, 22. Knapp DW, Small Animal Clinical Oncology (5 th ed), 2013, 23. Perazella MA, Semin Nephrol. 2010, 24. Rao P, J Pharm Pharm Sci. 2008, 25. Allstadt SD, J Vet Intern Med 2015, 26. Knapp DW, ILAR J % 1. Moore AS, J Vet Intern Med. 1990, 2. Chun R, J Am Vet Med Assoc. 1996, 3. Knapp DW, Cancer Chemother Pharmacol. 2000, 4. Chun R, Vet Intern Med. 1997, 5. Knapp DW, J Vet Intern Med. 1994, 6. Mutsaers AJ, J Vet Intern Med. 2003, 7. Knapp DW, J Vet Intern Med. 2013, 9. Arnold EJ, J Vet Intern Med. 2011, 12. Robat C, J Small Anim Pract. 2013, 13. Mohammed SI, Cancer Res. 2002, 14. Mohammed SI, Mol Cancer Ther. 2003, 15. Boria PA, Vet Comp Oncol. 2005, 16. Greene SN, J Am Vet Med Assoc. 2007, 18. Marconato L, J Am Vet Med Assoc. 2011, 19. Kaye ME, Vet Comp Oncol. 2013, 20. Schrempp DR, J Am Vet Med Assoc. 2013, 21. Henry CJ, Clin Cancer Res. 2003, 22. Knapp DW, Small Animal Clinical Oncology (5 th ed), 2013, 23. Perazella MA, Semin Nephrol. 2010, 24. Rao P, J Pharm Pharm Sci. 2008, 25. Allstadt SD, J Vet Intern Med 2015, 26. Knapp DW, ILAR J. 2014
14 53 % 1. Moore AS, J Vet Intern Med. 1990, 2. Chun R, J Am Vet Med Assoc. 1996, 3. Knapp DW, Cancer Chemother Pharmacol. 2000, 4. Chun R, Vet Intern Med. 1997, 5. Knapp DW, J Vet Intern Med. 1994, 6. Mutsaers AJ, J Vet Intern Med. 2003, 7. Knapp DW, J Vet Intern Med. 2013, 9. Arnold EJ, J Vet Intern Med. 2011, 12. Robat C, J Small Anim Pract. 2013, 13. Mohammed SI, Cancer Res. 2002, 14. Mohammed SI, Mol Cancer Ther. 2003, 15. Boria PA, Vet Comp Oncol. 2005, 16. Greene SN, J Am Vet Med Assoc. 2007, 18. Marconato L, J Am Vet Med Assoc. 2011, 19. Kaye ME, Vet Comp Oncol. 2013, 20. Schrempp DR, J Am Vet Med Assoc. 2013, 21. Henry CJ, Clin Cancer Res. 2003, 22. Knapp DW, Small Animal Clinical Oncology (5 th ed), 2013, 23. Perazella MA, Semin Nephrol. 2010, 24. Rao P, J Pharm Pharm Sci. 2008, 25. Allstadt SD, J Vet Intern Med 2015, 26. Knapp DW, ILAR J
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I II II 1 dw = pd = 0 1 U = Q (4.10) 1K (heat capacity) (mole heat capacity) ( dq / d ) = ( du d C = / ) (4.11) du = C d U = C d (4.1) 1 1 du = dq + dw dw = pd dq = du + pd (4.13) p dq = d( U + p ) p (4.14)
Juntendo Medical Journal
The hair growth effect of minoxidil Susumu OTOMO, Ph. D. Key words : minoxidil, minoxidil sulfate, hair growth, K+-channel opener, male pattern baldness Dept. of Pharmacology, Research Center Taisho Pharmaceutical
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1 5% 4% 11% 8% 13% 12% 10% 6% 17% 6% 8% 4% 6% 6% 2% 17% 17% 12% 14% 16% 6% 37% 11% 17% 35% 2 (N=6,239) 0 200 400 600 800 1,000 1,200 1,400 1,600 1,800 1,585 1,126 950 494 345 296 242 263 191 150 131 116
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Mg-LPSO 2566 2016 3 2001 Mg-Zn-Y LPSO(Long Period Stacking Order) Mg,,,. LPSO ( ), Mg, Zn,Y. Mg Zn, Y fcc( ) L1 2. LPSO Mg,., Mg L1 2, Zn,Y,, Y.,, Zn, Y Mg. Zn,Y., 926, 1 1,.,,., 1 C 8, 2 A 9.., Zn,Y,.
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twatanab@oncoloplan.com http://www.oncoloplan.com I II - III IV Fig 3. Survival curves overall and according to response Bruzzi, P. et al. J Clin Oncol; 23:5117-5125 25 Copyright merican Society of Clinical