化学療法剤の適切な使い方について

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1

2 5 6 7 Che E, in Cancer: Principles & Practice of Oncology (7th ed) in Devita, 2005 Marangolo M, Oncol Rep, 2006 hryniuk WM, Important Adv Oncol, Cancer: Principles & Practice of Oncology 5th Ed. Devita, 1997

3 9 Rassnick KM, Vet Comp Oncol, 2010 Vaughan A, JVIM, 2007 Frimberger AE, JVIM, IIIVn= 66 L-CHOP-CCNU-MOPP p= 0.05 L-CHOP Rassnick KM, Vet Comp Oncol, IIIVn= Vaughan A, JVIM, IIIVn= 28 VELCAP p= Frimberger AE, JVIM, 2006

4 13 14 CCNU (70mg/m 2 ) CCNU(60mg/m 2 ) CCNU (60mg/m 2 ) CCNU (60mg/m 2 ) SD PR CR Grade4 Seg= 37 Grade4 Seg= 34 Grade4 Seg= 251 Grade4 Seg= kg 16

5 17 Ogilvie GK, JAVMA, !20 PDGFR= VEGFR= PDGF PDGF & PDGFR-β binding VEGF PDGFR-β トセラニブ VEGF & VEGFR-2 binding VEGFR-2 トセラニブ

6 21 London CA, Vet Compar Oncol, n= 85 % n=32 n=23 n=15 n=8 n=7 London CA, Vet Compar Oncol, n= 85 London CA, Vet Compar Oncol,

7 25!26 27 Samm, 2010 Phillips, 2009 Kow, CI: -211 to -52) Boerman I, BMC Vet Res,

8 !29! Give Up? Yeah, used to be...!32 286

9 !33 363!34 412!35 440!36 475

10 !37 501! Lee KW et al., Cancer, 2003

11 41 Lee KW et al., Cancer,

12 45 46 n CR CR 9 50% 5 Jeglum KA, JAVMA, % 7.1 Mahony OM, JAVMA, Vail DM, JVIM, % 4.7 Zwahlen CH, JAVMA, % 8.2 Teske E, JVIM, % 34.8 Limmer S, VCO, % 1.7PFI Collette SA, VCO, 2015 * CHOP 47!48 n=20 Gouldin ED, VCO, 2015

13 49 Rassnick KM, JAVMA, Dank G, Vet Comp Oncol, % 1. Moore AS, J Vet Intern Med. 1990, 2. Chun R, J Am Vet Med Assoc. 1996, 3. Knapp DW, Cancer Chemother Pharmacol. 2000, 4. Chun R, Vet Intern Med. 1997, 5. Knapp DW, J Vet Intern Med. 1994, 6. Mutsaers AJ, J Vet Intern Med. 2003, 7. Knapp DW, J Vet Intern Med. 2013, 9. Arnold EJ, J Vet Intern Med. 2011, 12. Robat C, J Small Anim Pract. 2013, 13. Mohammed SI, Cancer Res. 2002, 14. Mohammed SI, Mol Cancer Ther. 2003, 15. Boria PA, Vet Comp Oncol. 2005, 16. Greene SN, J Am Vet Med Assoc. 2007, 18. Marconato L, J Am Vet Med Assoc. 2011, 19. Kaye ME, Vet Comp Oncol. 2013, 20. Schrempp DR, J Am Vet Med Assoc. 2013, 21. Henry CJ, Clin Cancer Res. 2003, 22. Knapp DW, Small Animal Clinical Oncology (5 th ed), 2013, 23. Perazella MA, Semin Nephrol. 2010, 24. Rao P, J Pharm Pharm Sci. 2008, 25. Allstadt SD, J Vet Intern Med 2015, 26. Knapp DW, ILAR J % 1. Moore AS, J Vet Intern Med. 1990, 2. Chun R, J Am Vet Med Assoc. 1996, 3. Knapp DW, Cancer Chemother Pharmacol. 2000, 4. Chun R, Vet Intern Med. 1997, 5. Knapp DW, J Vet Intern Med. 1994, 6. Mutsaers AJ, J Vet Intern Med. 2003, 7. Knapp DW, J Vet Intern Med. 2013, 9. Arnold EJ, J Vet Intern Med. 2011, 12. Robat C, J Small Anim Pract. 2013, 13. Mohammed SI, Cancer Res. 2002, 14. Mohammed SI, Mol Cancer Ther. 2003, 15. Boria PA, Vet Comp Oncol. 2005, 16. Greene SN, J Am Vet Med Assoc. 2007, 18. Marconato L, J Am Vet Med Assoc. 2011, 19. Kaye ME, Vet Comp Oncol. 2013, 20. Schrempp DR, J Am Vet Med Assoc. 2013, 21. Henry CJ, Clin Cancer Res. 2003, 22. Knapp DW, Small Animal Clinical Oncology (5 th ed), 2013, 23. Perazella MA, Semin Nephrol. 2010, 24. Rao P, J Pharm Pharm Sci. 2008, 25. Allstadt SD, J Vet Intern Med 2015, 26. Knapp DW, ILAR J. 2014

14 53 % 1. Moore AS, J Vet Intern Med. 1990, 2. Chun R, J Am Vet Med Assoc. 1996, 3. Knapp DW, Cancer Chemother Pharmacol. 2000, 4. Chun R, Vet Intern Med. 1997, 5. Knapp DW, J Vet Intern Med. 1994, 6. Mutsaers AJ, J Vet Intern Med. 2003, 7. Knapp DW, J Vet Intern Med. 2013, 9. Arnold EJ, J Vet Intern Med. 2011, 12. Robat C, J Small Anim Pract. 2013, 13. Mohammed SI, Cancer Res. 2002, 14. Mohammed SI, Mol Cancer Ther. 2003, 15. Boria PA, Vet Comp Oncol. 2005, 16. Greene SN, J Am Vet Med Assoc. 2007, 18. Marconato L, J Am Vet Med Assoc. 2011, 19. Kaye ME, Vet Comp Oncol. 2013, 20. Schrempp DR, J Am Vet Med Assoc. 2013, 21. Henry CJ, Clin Cancer Res. 2003, 22. Knapp DW, Small Animal Clinical Oncology (5 th ed), 2013, 23. Perazella MA, Semin Nephrol. 2010, 24. Rao P, J Pharm Pharm Sci. 2008, 25. Allstadt SD, J Vet Intern Med 2015, 26. Knapp DW, ILAR J

15 !57!58 60

16 61 Berg J, Cancer, n= 102) mg/m 2 IV 60mg/m 2 ) IV 23 x 3 Berg J, Cancer, n vs. P< vs. 10p=0.727 Berg J, Cancer, Berg J, Cancer, 1997

17 65 Berg J, Cancer,

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