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1 3 A B C
2 A A
3 A
4 3 1 A proven invasive fungal diseases BAL 24 : Fusarium spp. 4 2 : Candida Trichosporon B probable invasive fungal diseases Cpossible invasive fungal diseases Grocott-Gomori methenamine Periodic Acid Schiff PAS Calcofluor Blancophor 3 proven mold invasive fungal disease 4 Fusarium spp. proven invasive fungal disease
5 A T mm mg kg 3 ABPA 4 90 TNF- 5 A CT halo sign Air-crescent sign B 6 MRI CT Bull s eye 1BAL 2 3 sign 4 ELISA a bbal CSF 5 Rhizopus spp. Rhizomucor spp. Absidia spp. -D- 6 PCR PCR BALF PCR 65
6 3 3 66
7 A
8
9 A 1 69
10 3 2 AMPH-B 2 2 AMPH-B L-AMB AMPH-B ITCZ L-AMB VRCZ L-AMB ,
11 A
12 3 3 72
13 A
14 3 74
15 A 75
16 3 76
17 B-1 B
18 3 2. CNPA 78
19 B-1 3. IPA 79
20 3 4. HIV 80
21 B-1 81
22 B-2 B
23 B
24 3 4 84
25 B
26 3 86
27 C C proven fungal infection 2. clinically documented fungal infection probable fungal infection 3. possible fungal infection
28 3 1 88
29 C 2. empiric therapy 1 95 CI ICU
30 3 90
31 D D
32 3 1. empiric therapy 2. targeted therapy 1 92
33 D 1 Candida species FLCZ VRCZ AMPH-B C. albicans S S S S C. tropicalis S S S S C. parapsilosis S S S to? S C. glabrata S-DD to R S to S S to C. krusei R S to S S to C. Iusitaniae S S S S to R I RSS-DD 1.0 Candida spp. colonization index Days 1 colonization Candida spp. colonization index Days 2 93
34
35 E E ? 1 %
36 3 1 2.? 3.?
37 E possible -D- 1 G: pg ml W: pg ml 2 X CT 2 probable -D- G: pg ml W: pg ml 3 X CT -D- G: 100 pg ml W: 50 pg ml PCR 3 X CT proven G: RG W: - 1 -D- -D
38 Fos FLCZ mg 5.0 mg kg 1 1 ITCZ MCFG AMPH-B L-AMB Fos FLCZ MCFG AMPH-B L-AMB mg mg 1 1 AMPH-B ITCZ MCFG mg mg mg mg kg AMPH-B mg kg mg kg mg mg kg 1 1 loading dose mg mg 1 1 L-AMB VRCZ MCFG mg kg mg kg loading dose 6.0 mg kg mg mg kg AMPH-B mg kg mg kg 1 1 L-AMB ITCZ loading dose 59 MCFG Fos FLCZ F-FLCZ FLCZF-FLCZ FLCZ AMPH-B VRCZ 58 ITCZ mg kg mg1 1 loading dose 200 mg
39 E Fos FLCZ mg mg kg 1 1 loading dose mg MCFG mg 1 1 VRCZ 4.0 mg kg loading dose 6.0 mg kg 1 2 AMPH-B mg kg 1 1 L-AMB mg kg 1 1 ITCZ 200 mg 1 1 loading dose 200 mg VRCZ 4.0 mg kg loading dose 6.0 mg kg 1 2 MCFG mg 1 1 AMPH-B 5-FC L-AMB ITCZ Fos FLCZ 5-FC ITCZ 5-FC VRCZ AMPH-BL-AMB 5-FC FLCZ loading dose 59 Fos FLCZ F-FLCZ FLCZF-FLCZ FLCZ AMPH-B ITCZ58 VRCZ mg kg mg kg mg kg mg1 1 loading dose 200 mg mg 1 1 loading dose mg mg kg mg 1 1 loading dose 200 mg mg kg mg kg loading dose 6.0 mg kg mg kg L-AMB mg kg mg kg mg 99
40
41 E
42 3 102
43 F F
44
45 F empiric therapy 105
46 FDA AMPH-B FLCZ ITCZ 5-FC MCFG VRCZ A B C D X B C C C C C B D 106
47 F
48 3 108
49 G G
50
51 G 111
52 H H
53 H
54
55 H 1 MIC: g ml AMPH-B 5-FC MCZ FLCZ ITCZ MCFG VRCZ 0.6 mg kg 1.5 g 1,000 mg 200 mg 100 mg 2.5 mg kg 400 mg ND ND Candida albicans C. glabrata C. krusei C. parapsilosis C. tropicalis
56 AMPH-B MCZ FLCZ ITCZ MCFG VRCZ g 0.1 ml g ml
57 H 117
58 I I Extramucosal non-invasive fungal rhinosinusitis Superficial sinonasal mycosis Fungal ball Allergic fungal rhinosinusitis Invasive fungal rhinosinusitis Chronic invasive indolent fungal rhinosinusitis Acute fulminant fungal rhinosinusitis
59 I
60 3 120
61 J HIV J
62 3 2 HIV HIV 3. 1 HIV 4. PCP 1PCP HIV 122
63 J HIV 2PCP 3 ST 123
64 3 124
65 K 1 125
66
67 K
68 2007 Guidelines for Management of Deep-seated Mycoses 2007 ISBN C E
THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr non-albicans 4 non-albicans C. glabrata, C. parapsilosis, C. tropicalis, C. krusei 4 C. guil
Apr. 2012 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 111 13 B ACTIONs Bundle ACTIONs Bundle 2009 7 ACTIONs Bundle ACTIONs project Appropriate Candidal Treatment, Implementation Of Nonneutropenic strategies
112 54 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 Apr. 2013 8 2005 3 10 8 2012 6 7 B 2 NTT 2012 6
Apr. 2013 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 111 53 8 8 1. Ph-ALL Liposomal amphotericin B 1 2. CBT MCFG L-AMBAML 2 112 54 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 Apr. 2013 8 2005 3 10 8 2012 6
感染症学雑誌第80巻第6号
Candida Candida albicans Candida parapsilosis Candida glabrata Candida tropicalis C. albicans C. grabrata C. tropicalis µ Candida guilliermondii µc. parapsilosis µ Candida µcandida C. albicans µ µ µ µ
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1.8.2 Page MIC () MIC 50 / MIC 90 µg/ml Candida albicans (54) / Candida glabrata (25) 0.25 / 0.5 Candida guilliermondii a) (2)
1.8.2 Page1 1.8.2 96% 2002 40 B 1 123 (1) in vitro 1) in vitro C. glabrata C. krusei 1 2 19951997 3 1999 2002 MIC MIC 2 1.8.2 Page2 1 19951997 MIC () MIC 50 / MIC 90 µg/ml Candida albicans (54) 0.016 /
23 3 11 14 46 9.0 7 10m 40.1m 15,883 2,681 25 4 10 39 40 800 180 24 2425 22 21 24 5 3 21 24 10,899 20,472 13,723 33,007 667 400 79,167 8,620 11,694 10,089 25,131 690 215 56,439 13,614 20,897 15,200 32,213
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Feb. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 1 51(51) ABPA(M) 1 ABPM ITCZ 2 ABPA ITCZ 3 ABPA ABPM ABPM 52(52) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 1 Feb. 9 2004 3 6 4 Feb. THE JAPANESE JOURNAL OF ANTIBIOTICS
Candida albicans In Vitro Diagnostics (13)--D-Glucan Determination Reagents
D 012 Candida albicans In Vitro Diagnostics (13)--D-Glucan Determination Reagents DATA : 1 DATA : 2 3 DATA : UNGITEC 1 1 DATA : 20pg/mL 1020pg/mL 10pg/mL (cut off 20pg/mL) 90.2%(37/41) 100%(85/85) 96.8%(122/126)
10 44 1.2 5 4 5 3 6-1 - 1 2 3 4 5 1 2 3 4 5 6 7 8 1 2 3 4 5 6 7 8 9 10 TEL TEL 1 2 TEL FAX TEL FAX TEL FAX 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 1 2 3 4 5 6 ( ) ( ) 2
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Study on Clinical Factors Affecting the Fungal Culture Test - Relevance of Dry Mouth - Yoshiko YAMAMURA, Yukihiro MOMOTA, Hideyuki TAKANO, Koichi KANI, Katsumi MOTEGI, Fumihiro MATSUMOTO, Masayuki AZUMA
Key words: Candida, fungemia, antifungal activity, micafungin, fluconazole-resistant
Key words: Candida, fungemia, antifungal activity, micafungin, fluconazole-resistant Fig. 1 Annual changes in percentages of fungi isolated from blood and vascular catheters Fig. 2 Frequencies of fungi
Key words: yeast, Etest(R), microdilution method, MIC Table 1 MICs of quality control strains The data shown are the range of MIC performed in triplicate Table 2 Renge of MICs, MIC50s and MIC90s for 81
日本化学療法学会雑誌第56巻第3号
β Key words Candida albicans albicans Candida C. albicans Candida glabrata Candida krusei albicans Candida C. glabrata C. albicans albicans Candida β in vitro in vivo C. glabrata C. krusei I β γ µ Candida
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日本化学療法学会雑誌第54巻第S-1号
β β Key words β Candida krusei Candida glabrata β I β Drugadministration Baselinecharacteristics Clinicalsymptom Mycologicaltests Plasmadrugconcn Adverseevents Laboratorytests ) -leadecg Clinicalphotograph
38 38 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 1 Feb CT A B A CT B 20xx 2 8 LAM 20xx 1 12 CT S6, S10 Aspergillus spp. Micafungin MCFG 150 mg/ I
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2011 年 11 月 30 日放送 真菌感染症 兵庫医科大学感染制御学教授竹末芳生はじめに深在性真菌症の診断 治療ガイドラインの改訂版が 2007 年に発表され それを普及させる目的で 真菌症フォーラムでは ACTIONs プロジェクトを行ってきました これは侵襲性カンジダ症の病態 診断 治療を Antifungals, Blood stream infection, Colonization &
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平成 25 年 11 月 29 日 ( 金 ) 第 7 回大阪真菌症研究会ホテル日航大阪 深在性真菌症の治療を考える 公益財団法人鹿島病院感染症診療支援センター 菅野治重 講演内容 1 深在性真菌症について 2 抗真菌薬について 3 抗真菌薬の感受性試験について 4 耐性菌の動向 5 今後の課題 内臓真菌症の推移 FLCZ ITCZ MCFG 50.00% VRCZ 40.00% 30.00% 20.00%
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原 著 日集中医誌.2010;17:33 ~38. 深在性真菌症の診断 治療における β-d- グルカン値の評価 *1 *1, 2, 5 *3 藤木早紀子志馬伸朗廣瀬有里 *4 *3, 5 小阪直史藤田直久 要約 : 目的 深在性真菌症の診断における β-d- グルカン (BDG) の測定意義と適正な適用 評価法を考察した 方法 単一大学病院の感染症検査室および薬剤部データベース解析により, 1998
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[] HIV 4 sexually transmitted diseases 1975 WHO 12 3 2 5 3 1 1 4 3 40 1 1947 4 WHO 1975 STDsexually transmitted diseases STIsexually transmitted infection 5 STD 5 10 20 5 5 HIV STD RTIreproductive tract
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1 e N >. C 40 41 2 >. C 3 >.. C 26 >.. C .mm 4 C 106 e A 107 1 C 2 C 3 C 4 C 1 C 2 C 3 C 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124
(1519) () 1 ( ) () 1 ( ) - 1 - - 2 - (1531) (25) 5 25,000 (25) 5 30,000 25,000 174 3 323 174 3 323 (1532) () 2 () 2-3 - - 4 - (1533) () 1 (2267)204 () (1)(2) () 1 (2267)204 () (1)(2) (3) (3) 840,000 680,000
平成２４年財政投融資計画ＰＤＦ出後８／０１６‐０３０
24 23 28,707,866 2,317,737 26,390,129 29,289,794 2,899,665 24 23 19,084,525 21,036,598 1952,073 24 23 8,603,613 8,393,427 967,631 925,404 202,440 179,834 217,469 219,963 66,716 64,877 3,160,423 2,951,165
1 2 http://www.japan-shop.jp/ 3 4 http://www.japan-shop.jp/ 5 6 http://www.japan-shop.jp/ 7 2,930mm 2,700 mm 2,950mm 2,930mm 2,950mm 2,700mm 2,930mm 2,950mm 2,700mm 8 http://www.japan-shop.jp/ 9 10 http://www.japan-shop.jp/
第18回海岸シンポジウム報告書
2011.6.25 2011.6.26 L1 2011.6.27 L2 2011.7.6 2011.12.7 2011.10-12 2011.9-10 2012.3.9 23 2012.4, 2013.8.30 2012.6.13 2013.9 2011.7-2011.12-2012.4 2011.12.27 2013.9 1m30 1 2 3 4 5 6 m 5.0m 2.0m -5.0m 1.0m