1 A : : 00 Rho G DOCK Rho G Rac1 DOCK GFP FRET Förster resonance energy transfer : Apico - Basal 3 FRET G 3 Rac1 Ras 1 A : :

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "1 A : : 00 Rho G DOCK Rho G Rac1 DOCK GFP FRET Förster resonance energy transfer : Apico - Basal 3 FRET G 3 Rac1 Ras 1 A : :"

Transcription

1 1 A : 00 9 : 40 SLE RA SLE RA 1 1 SLE RA SLE SLE 1,2,4,11,17 1 synteny SLE SLE 1 SLE RA SLE RA SLE RA 1 A : : 20 L L B L26 Ishii Y, et al. Clin Exp Immunol L26 CD20 L L22 B L22 Takami T, et al. J Immunol L22 L ALOX5 Nagashima T, et al. Am J Pathol ALOX5 Alox5 B T Tfh Tfh T T T Th0 Tfh ALOX5 L ALOX5 B T ALOX5

2 1 A : : 00 Rho G DOCK Rho G Rac1 DOCK GFP FRET Förster resonance energy transfer : Apico - Basal 3 FRET G 3 Rac1 Ras 1 A : : S19 RP S19 RP S19 Lys122 Gln137 RP S19 C5a Ca 2+ /Mg 2+ TRPM p38map RP S19 C5a Ca 2+ /Mg 2+ TRPM p38map A3 G 3 Gln137Asn - RP S19 HL - 60 RP S19 C5a C5a RP S19 C5a C5a RP S19 C5a RP S19 RP S19

3 1 B : : F. tularensis 2001 CDC A HE realtime PCR GenePoint Dako QIAGEN QIAamp FFPE DNA mini kit DanoDrop 0D 260 nm/280 nm 23kDa tul4 Taqman probe primer PCR MX3005 ABI Prism 7900HT : F. tularensis 12 1 : DNA japonica F. tularensis F. tularensis 1 14 : : 35 Pancreatic neoplasms and their different origins Günter Klöppel Department of Pathology, Technical University of Munich, Germany The exact morphological classification of tumors of the pancreas combined with their molecular analysis has broadened our understanding of cancer development and progression in the pancreas. It is evident from these studies that the general phenotypical classification of pancreatic neoplasms into tumors with either ductal, acinar, endocrine, or indeterminate differentiation is associated with distinct molecular profiles that suggest that there are profound differences in the molecular pathways that lead to the various types of pancreatic neoplasms. The molecular pathway of neoplasms with ductal differentiation is characterized by a K - ras mutation, which seems to mark the first step in the development of these cancers. The second step then includes alterations in the tumor suppressor genes p16, p53 and DPC4. Tumors with acinar, endocrine, or indeterminate differentiation, in contrast to ductal tumors, follow molecular pathways that are not initiated by a K - ras mutation. Instead, there is involvement of the APC/ β - catenin pathway, as in acinar cell carcinoma and pancreatoblastoma, the menin/loh 11q pathway, as in neuroendocrine tumors and the β - catenin pathway, as in solid - pseudopapillary tumors. The fact that the various molecular pathways are associated with certain phenotypes of the pancreatic neoplasms suggests that the stem cells from which the tumors originate are already more or less committed to distinct differentiation pathways.

4 : : matricellular RECK 3A 1 S1-1

5 1 S L/day 4 in situ II III ANCA 1 S1-3

6 1 S1-4 tumor necrosis factor - α interleukin6 50% angiotensinii matricellular matricellular, matricellular Tenascin - C 1 S1-5 osteoarthritis=oa II XI OA fibrillation cleft ADAMTS4, 5 MMP - 1, 13 chondrocyte cloning clustering OA chondrocyte cloning 2 RECK reversion - inducing cysteine - rich protein with Kazal motifs OA cloning OA RECK focal adhesion VEGF vascular endothelial growth factor OA VEGFR2-1 VEGF 165 3A cloning OA VEGF 165 3A

7 2 A : 50 9 : 30 β - catenin CTNNB1 CTNNB1 β - catenin β - catenin CTNNB1 CTNNB1 β - catenin 3 liver zonation CTNNB1 30% CTNNB1 β - catenin β - catenin β - catenin zone 3 necrosis β - catenin β - catenin CTNNB1 SLCO1B3 CTNNB1 SLCO1B3 CTNNB1 β - catenin 2 A : : 10 KEAP1 - NRF2 NRF2 KEAP1 E3 KEAP1 NRF2 N DLG ETGE NRF2 CGH KEAP1 KEAP1 Shibata et al, Gastroenterology, 2008, Ohta et al, Cancer Res, 2008 NRF2 Shibata et al, PNAS, 2008, Neoplasia, 2011 in press NRF2 DLG ETGE NRF2 KEAP1 NRF2 NRF2 mtor NRF2 mtor Shibata et al, Cancer Res, 2010 NRF2 NRF2 DeNicola GM et al, Nature, 2011 NRF2 NRF2 KEAP1 NRF2

8 2 A : : 50 divergent pathway 3 1 ALKBH ALKBH DNA 8 ALKBH - 3, 8 dysplasia grade ALKBH - 3, 8 ROS ALKBH - ROS - key signal ROS 2 Mitogen activated protein MAP MAP / MAP c - jun NH2 terminal kinase JNK MMP9 VEGF JNK JNK MAP kinase phosphatase MKP - 1 JNK JNK MKP CD138 plasmacytoid variant plasma cell marker CD138 CD138 CD138 sirna CD138 CD138 ALKBH CD138 JNK ROS A : : 30 blood - brain barrier : BBB BBB BBB BBB BBB BBB BBB mrna cdna BBB P - BBB P - Aβ Aβ LDL LDL CD36 P - CD36 BBB Aβ BBB matrix metalloproteinase MMP MMP - 1,2,3,9 MMP - 13 Hif - 1α T Hif - 1α T T Hif - 1α BBB Aβ MMP Hif - 1α Aβ

9 2 A : : : : 20 IgG4 : Institute of Liver Studies, King s College Hospital, London IgG4 : IgG4 IgG4 IgG4 IgG 40% IgG4 IgG4 Küttner : IgG4 IgG % 9% : IgG4 4 : Th2 IL - 4 IL - 5 IL - 13 Th2 mrna T IL - 10 TGF - β Th2 IgE IgG4 Th2 : IgG GIST

10 2 S2-1 2 S2-2 : GIST 1,2 1 2 K - ras EGFR HER - 2 MammaPrint Pathwork Tissue of Origin Test FDA EML4 - ALK BRAF K - ras 2,000 2 EGFR HER - 2 FISH FDA Home Brew Test Oncotype Dx Mammaprint TAILORx MINDACT Companion Diagnostics GIST c - kit c - kit KIT c - kit KIT PDGFRα GIST c - kit PDGFRα GIST MIB - 1 Ki - 67 /PNET /PNET VAC VDC/IE GIST /PNET

11 2 S2-3 2 S2-4 EGFR ALK 60% EGFR 5% ALK EGFR ALK EML4 - ALK ALK EGFR BAC hobnail BAC hobnail EGFR ALK cribriform pattern ALK FISH RT - PCR iaep TP53 - TP oncogene - addiction KIT imatinib Glivec RNA : molecular taxonomy prognostic signature ER HER2 intrinsic subtype Luminal A, Luminal B, HER2, Basal - like, claudin - low, molecular apocrine MammaPrint, OncotypeDx, Theros, MapQuantDx GGI Intrinsic subtype PAM50 stem cell signature, fibroblast signature ER PgR HER2 Ki - 67 ER /HER2 ER PgR HER2 ER /HER2 Pertuzumab T - DM1 Neratinib p95her2 HER3 HER2 ER/HER2 PARP1 BRCA1 AR ERα33 ERβ1

12 2 S2-5 VEGF EGF EGF HER2 EGF DNA K - RAS K - RAS EGF K - RAS HER2 IHC3+IHC2+ FISH/DISH K - RAS B : : 45 HCA 90%, HCA 1 Hepatocyte nuclear factor 1α HNF1α 2 β - catenin 3 Inflammatory HCA IHCA 3 1 liver fatty acid binding protein LFABP 2 Glutamine synthetase GS 3 serum amyloid A SAA HCA HCA HCA 19 M/F=10/9, 40.8±15.0 LFABP GS SAA HCA 19 HNF1α % ; M/ F=0/2 40.5±4.9 β - catenin % ; M/F=1/1 28.5±3.5 IHCA % ; M/F=8/3 45.8± % ; M/F=1/3 33.5± IHCA 8 M/F=6/ % 36% 50% % 50% HCA % HCA 4.0±1.4 cm 17.5±2.1 cm 3.0±2.6 cm 4.4±2.6 cm β - catenin 1 HCA HNF1α IHCA

13 : : core needle biopsy : CNB vacuum associated biopsy : VAB OSNA HER2 1. ER PgR HER : : A. CIN CIN HPV p16 INK4a Ki - 67 CIN1 CIN2 HPV B. p63 CK5/6 2. A. ER p16 INK4a B. p16 INK4a WHO glandular dysplasia de novo C.

; cm 4. ; 2. ; 3. ; 5. 2 ; 120 ng/ml Mφ 6 7, 8 9

; cm 4. ; 2. ; 3. ; 5. 2 ; 120 ng/ml Mφ 6 7, 8 9 32, 21-25, 2012 CASLE 1 1 80 26 6 5 4 cm 1 2 CEA 3 4 CEA 2 44 22 2 3 1.5 cm 22 1. 1 ; 6 5 4 cm 4. ; 2. ; 3. ; 5. 2 ; 120 ng/ml 0-40 5 Mφ 6 7, 8 9 23 6. ; 9. ; 7. ; 10. ; 8. 7 10 CK3 CK3 24 1,2 3 2 8% 4,5

More information

2

2 2 3 4 5 6 7 8 9 1 2 3 4 5 10 11 12 1 2 1 2 1 2 13 14 3 17 15 1 2 3 D Usefulness of Tc-99m MIBI SPECT in predicting multidrug resistance gene expression level in non-small cell lung cancer a preliminary

More information

第14〜15回 T細胞を介する免疫系.pptx

第14〜15回 T細胞を介する免疫系.pptx MBL CD8 CD4 8.1 8.2 5.20 8.3 8.4 8.5 8.6 8.7 8.8 8.9 8.10 8.18 B7 CD28 CD28 B7 CD28 8.13 2.22 NK Toll(TLR) LBP! LPS dsrna ssrna TLR1/2/6! TLR4 TLR5 TLR3 TLR7/9 CD14! JNK/p38! MyD88! IRAK! TRAF! NFκB! TNF-α

More information

mrna Zc3h12a IL-6

mrna Zc3h12a IL-6 mrna Zc3h12a IL-6 IgG4 The 4th East Asian Group of Rheumatology (EAGOR2011) S3PE CaMK EBM PubMed NHK TBS European Thyroid Journal Nature, Lancet msv ICRP msv msv msv WHO COE sirna M M M VS VS VS

More information

untitled

untitled COLAK Mehmed 11000 305 305 180 10000 9000 8000 160 140 120 7000 100 6000 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 80 GH IGF-1 GH GH 5 4 3 2 1 0 2 3 4 5

More information

9 : 00 11 : 00 12 : 00 12 : 10 12 : 50 13 : 30 14 : 40 16 : 00 17 : 00

9 : 00 11 : 00 12 : 00 12 : 10 12 : 50 13 : 30 14 : 40 16 : 00 17 : 00 9 : 00 11 : 00 12 : 00 12 : 10 12 : 50 13 : 30 14 : 40 16 : 00 17 : 00 ポスターについて 1. ポスター 貼 付 用 の 展 示 ボードは 縦 180 横 90cm の 大 きさです 2. 演 題 名 発 表 者 名 所 属 を 明 記 したもの(20 70cm) をご 用 意 ください 実 際 使 用 できるスペースは 155

More information

indd

indd Molecular Targeted Therapy for Lung Cancer from a Pharmaceutical Point of Viewe Naho SASAKI epidermal growth factor receptor tyrosine kinase inhibitor :EGFR-TKI vascular endothelial growth factor:vegf

More information

pp 427 438 2006 Dimensional Change Card Sort ****** ** 2005 9 30 2004 8 2002 4 Zelazo, P. D., Carter, A., Reznick, J. S. & Frye, D. 1997 10 2003 Zelaz

pp 427 438 2006 Dimensional Change Card Sort ****** ** 2005 9 30 2004 8 2002 4 Zelazo, P. D., Carter, A., Reznick, J. S. & Frye, D. 1997 10 2003 Zelaz Title 幼 児 の 実 行 機 能 の 発 達 過 程 : Dimensional Change C を 用 いたルールの 理 解 とその 使 用 に 関 する 検 討 Author(s) 浮 穴, 寿 香 ; 橋 本, 創 一 ; 出 口, 利 定 Citation 東 京 学 芸 大 学 紀 要. 総 合 教 育 科 学 系, 57: 427-438 Issue Date 2006-02-00

More information

第124回日本医学会シンポジウム

第124回日本医学会シンポジウム III γ γ γ α γ Molecular Mechanism of Insulin Resistance by Adipocytes TAKASHI KADOWAKI Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo Key words γ 110 124 TNFα FFA 1,2

More information

untitled

untitled 13 13 2014 3 1415 TEL.0859-33-3531 / FAX.0859-33-3607 TEL 0859-38-6292 FAX 0859-38-6293 E-mail: gan-center@med.tottori-u.ac.jp 13 13 Department of Medical Oncology, Thomas Jefferson University) 1F 2F

More information

島根大チュートリアル学習2011

島根大チュートリアル学習2011 2011 Bench pathologist bench pathologist 2000 130 60 WHO UICC 1 34 6500 1-2% 1960 dysplasia squamous intraepithelial neoplasia SIN CIN cervical intraepithelial neoplasia WHO 1992 WHO 3 2005 basal cell

More information

19 8 1970 20 10 4 1

19 8 1970 20 10 4 1 19 8 1970 20 10 4 1 IgE 1960 % 1970 20%, 1990 40% 1998 70% 20 IgE 21 90% IgE IgE (%) 70 60 50 40 30 20 10 0 1970 1975 1980 1985 1990 1995 2000 2005 1. 2005 10 2 30 IgE 2. 3 1. B IgE T IgE IgE IgE 2 T IgE

More information

第4回 JISSスポーツ科学会議 ポスターセッション

第4回 JISSスポーツ科学会議 ポスターセッション - 33 - - 34 - - 35 - - 36 - - 37 - - 38 - 投 球 方 向 1 日 目 3 日 目 50cm - 39 - [First half] [Second half] Segment angle (deg) 40 30 20 110 100 90 80 70 60 50 40 30 80 70 Torso Thigh CM Z Torso Y Thigh Shank

More information

第79回_プログラム.indd

第79回_プログラム.indd Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons. Phase I clinical trial using peptide vaccine for human vascular endothelial

More information

Squamous metaplasia in the uterine cervix Kiichiro NODA Department obstetrics and gynecology, School of Medicine, Tohoku University The process of squamous metaplasia in the uterine cervix might be discussed

More information

免疫Ⅱ

免疫Ⅱ 100 100 100 1990 127 DNA DNA DNA DNA hybridization DNA RNA DNA DNA 128 12 µδγαε 129 300 1,200 500 50012 4 24,000 1,20024,000 2.910 7 10 8 rejection major histocompatibility complex MHC MHC MHC 130 MHC

More information

Table 1. Numbers of Cancerous Pleurisy Cases According to Primary Site Table 2. Histological Type of Lung Carcinoma with Cancerous Pleurisy at Autopsy

Table 1. Numbers of Cancerous Pleurisy Cases According to Primary Site Table 2. Histological Type of Lung Carcinoma with Cancerous Pleurisy at Autopsy Clinicopathological Studies on Cancerous Pleurisy, with Emphasis on Extra-Pulmonary Malignancy Table 1. Numbers of Cancerous Pleurisy Cases According to Primary Site Table 2. Histological Type of Lung

More information

表1.eps

表1.eps Vol.1 C ontents 1 2 cell-free EMBO J Proc. Natl. Acad. Sci. USA NatureEMBO J 3 RNA NatureEMBO J Nature EMBO J 4 5 HCV HCV HCV HCV RNA HCV in situ 6 7 8 Nat Struct Mol Biol J Biol Chem Nat Commun J Virol

More information

05_藤田先生_責

05_藤田先生_責 This report shows innovation of competency of our faculty of social welfare. The aim of evaluation competency is improvement in the Social welfare education effects, by understanding of studentʼs development

More information

Unknown

Unknown Journal of Breast and Thyroid Sonology Journal of Breast and Thyroid Sonology Vol.2, No.3 July 2013 Report The 30 th Meeting of Japan Association of Breast and Thyroid Sonology... 1 Department of Organ

More information

PCR 3 Mature mirna PCR 7 miscript mirna PCR Array C T 12 Mature mirna cdna 15 miscript mirna QC PCR Array miscript mirna PCR Array 10/2011

PCR 3 Mature mirna PCR 7 miscript mirna PCR Array C T 12 Mature mirna cdna 15 miscript mirna QC PCR Array miscript mirna PCR Array 10/2011 October 2011 miscript mirna PCR Array miscript II RT Kit miscript SYBR Green PCR Kit miscript mirna PCR Arrays miscript mirna QC PCR Array Pathway-Focused mirna PCR Array mirnome miscript mirna PCR Array

More information

24

24 24 1) Hales M, Resenau W, Okerlund MD, et al: Carcinoma of the thyroid with a mixed medul lary and follicular pattern: morphologic, im munohistochemical, and clinical laboratory studies. Cancer 50: 1352-1359,

More information

\ (1963): Recent Trends of Urban Geography in Japan A, A, A, G, 53 93^ 102 Yamaga S, & Y, Masai (1966) : Japanese Urban Geography-General View Japanese Geography 1966; Spec, Publ, No,1 Ass, Jap, Geogrs,

More information

~ ユリシーズ における語りのレベル Synopsis Who Is the Man in Macintosh? - Narrative Levels in Ulysses Wataru TAKAHASHI Who is the man in macintosh? This is a famous enigma in Ulysses. He comes out of the blue on the

More information

東洋医学雑誌

東洋医学雑誌 Vol.61 No.7 924-929, 2010 a b c d Naoki OKADA ad Masaru NATSUAKI b Takashi NISHIMOTO ac Nishimoto Clinic, 2-8-31 Koshienguchi, Nishinomiya, Hyogo 663-8113, Japan Department of Dermatology, Hyogo College

More information

BAANs理論に基づく保健指導プログラム暫定版

BAANs理論に基づく保健指導プログラム暫定版 WHO 4 5 10% L- -3 RNA L - 1960-3 RNA mrna Bio Activating Advanced Nutrients BAANs BAANs BAANs BAANs L- (NO) -3 EPA, DHA) RNA RNA DNA TNF- PAI-1 ( ) BAANs 40 50% 20% 1Kg 7,000Kcal 50Kcal 11 50Kcal

More information

NO.80 2012.9.30 3

NO.80 2012.9.30 3 Fukuoka Women s University NO.80 2O12.9.30 CONTENTS 2 2 3 3 4 6 7 8 8 8 9 10 11 11 11 12 NO.80 2012.9.30 3 4 Fukuoka Women s University NO.80 2012.9.30 5 My Life in Japan Widchayapon SASISAKULPON (Ing)

More information

AllPrep DNA/RNA Micro プロトコールとトラブルシューティング ( /2008)

AllPrep DNA/RNA Micro プロトコールとトラブルシューティング ( /2008) July 2007 AllPrep DNA/RNA Micro DNA RNA 5 x 10 5 5 mg Sample & Assay Technologies DNA RNA 3 DNA RNA 11 DNA RNA 19 24 2 AllPrep DNA/RNA Micro 07/2007 DNA RNA RNA AllPrep DNA Spin Column DNA RNeasy MinElute

More information

28 1 1a 1b 2 MRI T2 3 CT C3 N95 N95 6ml 90

28 1 1a 1b 2 MRI T2 3 CT C3 N95 N95 6ml 90 2015 28 1 89 93 CT C3 Tb PCR XP WBC 7 600/mm 3 CRP 4 08mg/dl MRI MRI CT MRI WBC 9 700/mm 3 CRP 6 09mg/dl CT C3 C2 C7 low density area CT 89 28 1 1a 1b 2 MRI T2 3 CT C3 N95 N95 6ml 90 28 1 4 CT C2 C7 low

More information

未婚者の恋愛行動分析 : なぜ適当な相手にめぐり会わないのか

未婚者の恋愛行動分析 : なぜ適当な相手にめぐり会わないのか Kwansei Gakuin University Rep Title 未 婚 者 の 恋 愛 行 動 分 析 : なぜ 適 当 な 相 手 にめぐり 会 わないのか Author(s) Nishimura, Tomo, 西 村, 智 Citation 経 済 学 論 究, 68(3): 493-515 Issue Date 2014-12-20 URL http://hdl.handle.net/10236/13428

More information

<96DA8E9F82D982A95F944E95F1906C8AD489C88A775F33332E696E6464>

<96DA8E9F82D982A95F944E95F1906C8AD489C88A775F33332E696E6464> 33 27-42 2012 27 4 4 4 1 4 4 4 4 1993:6 1910 1920 1993 1) 28 1987; 2004 2000; 2001 1997; 2000Heath and Cleaver 2003; 2008; 2009a DINKS 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4

More information

2 146

2 146 28 2004 pp. 145 159 1 Received October 29, 2004 In 1999, North Korea reversed the negative economic growth of the 90s, and displayed a positive trend which, although weak, was maintained at 1.8% in 2003.

More information

Z B- B- PHP - - [ ] PHP New York Times, December,,. The origins of the Japan-U.S. War and Adm. Isoroku Yamamoto Katsuhiko MATSUKAWA Abstract There are huge amount of studies concerning the origins

More information

研究報告B

研究報告B * ** Casualties by the 3 June 1991 pyroclastic flow at Unzen volcano Shinichi SUGIMOTO * and Daisuke NAGAI ** Abstract The 1990-1995 eruption of Unzen volcano, Japan, was characterized by lava dome growth

More information

ただし EMT はメタや invasion と 同 義 ではないことを 強 調 しておきたい c. Apoptosis や anoikis に 対 する 抵 抗 性 正 常 では 表 皮 細 胞 は 間 質 細 胞 との 接 着 に 失 敗 すると apoptosis(programmed cell

ただし EMT はメタや invasion と 同 義 ではないことを 強 調 しておきたい c. Apoptosis や anoikis に 対 する 抵 抗 性 正 常 では 表 皮 細 胞 は 間 質 細 胞 との 接 着 に 失 敗 すると apoptosis(programmed cell 癌 転 移 : 最 近 の 発 見 新 しい 治 療 戦 略 Metastasis: recent discoveries and novel treatment strategies The Lancet, vol369, No.9574, May 19-25, 2007, Suzanne A Eccles 他 西 伊 豆 早 朝 カンファランス 仲 田 1.Introduction 癌 転 移

More information

-1 - -2 - -3 - -4 - -5 - -6 - -7 - -8 - -9 - - 10 - -11 - - 12 - - 13 - - 14 - - 15 - - 16 - - 17 - - 18 - - 19 - - 20 - - 21 - - 22 - - 23 - - 24 - - 25 - - 26 - - 27 - - 28 - - 29 - - 30 - - 31 - - 32

More information

【教】⑮長島真人先生【本文】/【教】⑮長島真人先生【本文】

【教】⑮長島真人先生【本文】/【教】⑮長島真人先生【本文】 CD CD CD CD CD pp pp pp p p p p p pp PP p pp pp pp p Characteristics and Potentialities of the School Song Ware Wa Uminoko : Based on an Analysis and an Interpretation of the Song as a Music Teaching

More information

Author Workshop 20111124 Henry Cavendish 1731-1810 Biot-Savart 26 (1) (2) (3) (4) (5) (6) Priority Proceeding Impact factor Full paper impact factor Peter Drucker 1890-1971 1903-1989 Title) Abstract

More information

ABSTRACT The Social Function of Boys' Secondary Schools in Modern Japan: From the Perspectives of Repeating and Withdrawal TERASAKI, Satomi (Graduate School, Ochanomizu University) 1-4-29-13-212, Miyamaedaira,

More information

t Uhlenhaut NH, Jakob S,Anlag K, et al. Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell. 2009;139(6): ll3o-42. 2 Chalvardjian A, Scully RE. Sclerosing stromal tumors of

More information

02[021-046]小山・池田(責)岩.indd

02[021-046]小山・池田(責)岩.indd Developing a Japanese Enryo-Sasshi Communication Scale: Revising a Trial Version of a Scale Based on Results of a Pilot Survey KOYAMA Shinji and IKEDA Yutaka Toward exploring Japanese Enryo-Sasshi communication

More information

untitled

untitled 11-19 2012 1 2 3 30 2 Key words acupuncture insulated needle cervical sympathetick trunk thermography blood flow of the nasal skin Received September 12, 2011; Accepted November 1, 2011 I 1 2 1954 3 564-0034

More information

Title 骨量規定転写因子シュニュリ3の新規標的遺伝子同定と機能解析 Author(s) 石堂, 康弘 Citation Issue Date 2014-06-27 URL http://hdl.handle.net/10232/24125 http://ir.kagoshima-u.ac.jp adult (Schnurri, Shn)3/Hivep3 Runx2 Shn/Hivep Shn3

More information

中高齢者の健康・いきいきライフスタイルづくり調査

中高齢者の健康・いきいきライフスタイルづくり調査 1 -- -- 10 11 12 1998-2000 Exercise: A Guide from the National Institute on Aging 1 61-80 26 T PHA Streptoccocal enterotoxin ASEA (IL-2; Th1 ) IL-4Th2 IgE T T - Bcl-2 Fas T PHA SEA IL2 T PHA SEA IL2

More information

【生】④廣瀬政雄先生【本文】/【生】④廣瀬政雄先生【本文】

【生】④廣瀬政雄先生【本文】/【生】④廣瀬政雄先生【本文】 YOMIURI ONLINE MSN Jp Yahoo!Japan HIV RS MR MR Statens Serum human immunodefficiency virus HIV HIV HIV UNAIDS WHO HIV HIV HIV NGO WHO CDC CDC RS RS E T A E T ATL Adult T cell leukemia ATL A A O O O O O

More information

AS アハ ートE AS アハ ート 27 AS アハ ート 27

AS アハ ートE AS アハ ート 27 AS アハ ート 27 IL1 4 29 16 00 18 30 アハ ート Mythe de l intériorité et aporie de la psychologie développementale 27 Université Paris, FR IL2 4 30 9 00 11 00 アハ ート Diversity in the Development of the Social Brain Birkbeck,

More information

情意要因が英語の読解力と会話力に及ぼす影響-JGSS-2008 のデータから-

情意要因が英語の読解力と会話力に及ぼす影響-JGSS-2008 のデータから- JGSS-2008 The Influence of Affective Factors on English Reading and Conversation Proficiency among Japanese from the Data of JGSS-2008 Kaoru KOISO Faculty of Business Administration Osaka University of

More information

星医会00表紙.pdf

星医会00表紙.pdf H A,, , ,,, Facebook PSP PSP in situ hybridization New York Bronx Veterans Administration Hospital, Alcohol Research and Treatment Center demanding education e-ducare S. M. McCann Proc. Natl. Acad.

More information

平成14年度 本態性多種化学物質過敏状態の調査研究 研究報告書

平成14年度 本態性多種化学物質過敏状態の調査研究 研究報告書 226 227 µ 228 Ω 229 230 0 ppb 2000ppb DG subthreshold (µa) 91 ± 59 86 ± 68 max stim. (µa) 755 ± 287 n=37 678 ± 300 max PS (mv) 8.7 ± 3.9 7.7 ± 4.3 n=61 CA1 subthreshold (µa) 36 ± 26 32 ± 13 max stim. (µa)

More information

フィナレビ106号.indb

フィナレビ106号.indb 2009 3 30 2009 4 14 CDC 2009 4 25 WHO 2009 4 26 2009 4 28 2009 4 28 2009 4 30 2009 5 1 2009 5 8 6 2009 5 9 2009 5 23 2009 6 3 2009 6 9 2500 2009 6 12 WHO 6 2009 6 28 2009 8 9 1 1 2009 8 15 2009 8 19 2010

More information

Otto Friedrich Bollnow,~

Otto Friedrich Bollnow,~ Summary: In the modern society the development of children s cheerful feeling is gradually declined. The change of society for example, a low birth rate and nuclear family tendency affects children s lives.

More information

(1) a. He has gone already. b. He hasn't gone yet. c. Has he gone yet?

(1) a. He has gone already. b. He hasn't gone yet. c. Has he gone yet? Title yet についての 一 考 察 : yet, already, still, だ と もう Author(s) 吉 村, あき 子 Citation Osaka Literary Review. 28 P.16-P.29 Issue 1989-12-20 Date Text Version publisher URL http://hdl.handle.net/11094/25546 DOI

More information

Hirosaki University Repository 妊 娠 可 能 てんかん 女 性 の 治 療 管 理 基 準 設 定 に 関 する 研 Title 究 Author(s) 兼 子, 直 Citation てんかん 治 療 研 究 振 興 財 団 研 究 年 報. 4, 1992, p.24-35 Issue Date 1992 URL http://hdl.handle.net/10129/1905

More information

1 Department of Legal Medicine, Toyama University School of Medicine 2 3 4 5 6 7 8 Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama VEGF Key words

More information

/†yL:†zServer/−Ö’¼−w›@‚å−w/”Лï−wŁfl‰IŠv/”Лï−wŁfl‰IŠv‚æ108“ƒ/‘¼Œ{ Š²”u

/†yL:†zServer/−Ö’¼−w›@‚å−w/”Лï−wŁfl‰IŠv/”Лï−wŁfl‰IŠv‚æ108“ƒ/‘¼Œ{ Š²”u October October OB OB BLACK EMPEROR vol OB October P P OB P P October PL OB October B A. K. Cohen push pull October P G. H. P P P P A. K. Cohen Cohen, A. K. Delinquent Boys; the culture of gang, Free

More information

untitled

untitled [] 2007 3 2 Hodgkin Plasma cell dysclasia Atrial myxoma with emboli histiocytosis multicentric reticulohistiocytosis Schuller-Christian Gaucher Weber-Christian 1.SLE 2. Gottron Gottron 3. sclerodactyly

More information

Š²”u

Š²”u Kwansei Gakuin University Rep Title 不 良 物 語 という 名 の 搾 取 構 造 Author(s) Matsumoto, Takashi, 松 本, 隆 志 Citation 関 西 学 院 大 学 社 会 学 部 紀 要, 108: 85-98 Issue Date 2009-10-30 URL http://hdl.handle.net/10236/3262

More information

化学療法剤の適切な使い方について

化学療法剤の適切な使い方について 1 2 3 4 5 6 7 Che E, in Cancer: Principles & Practice of Oncology (7th ed) in Devita, 2005 Marangolo M, Oncol Rep, 2006 hryniuk WM, Important Adv Oncol, 1988 8 Cancer: Principles & Practice of Oncology

More information

C 1) 2) 3) 4) 5) 6) 7) 8) 9)

C 1) 2) 3) 4) 5) 6) 7) 8) 9) 130603 (1-3) C 1) 2) 3) 4) 5) 6) 7) 8) 9) C 1) 2) 3) DNA 4) DNA RNA 5) 6) PCR 7) DNA C Cyclops Odlilon Redon, The Cyclops, 1914 WAGR www.wagr.org WAGR www.wagr.org Cell 126, 663-676, 2006 Wikipedia

More information

日本看護管理学会誌15-2

日本看護管理学会誌15-2 The Journal of the Japan Academy of Nursing Administration and Policies Vol. 15, No. 2, PP 135-146, 2011 Differences between Expectations and Experiences of Experienced Nurses Entering a New Work Environment

More information

II

II No. 19 January 19 2013 19 Regionalism at the 19 th National Assembly Elections Focusing on the Yeongnam and Honam Region Yasurou Mori As the biggest issue of contemporary politics at South Korea, there

More information

無水エタノールによる硬化療法および鼻粘膜癒着処置を施行したオスラー病による難治性鼻出血の1例

無水エタノールによる硬化療法および鼻粘膜癒着処置を施行したオスラー病による難治性鼻出血の1例 119 874 2016 : 0 1cc : : : : : :WBC3 640/μl RBC 247 10 /μl PLT 22 9 10 /μl Hb 7 9g/dl PT APTT : : : 1ml 30G absolute ethanol Et 0 1 0 2ml 2mm 119 875 1 000mg/day Et 0 3ml Al Deen endoglin ALK1 1 3 a b

More information

..

.. A general framework of interventional study in cognitive rehabilitation for the elderly. YOSHIDA Hajime, OOKAWA Ichiro and TUCHIDA Noriaki The present article describes the general framework of our interventional

More information

Studies on the Antigens Expressed on Trophoblasts Related to MLR-blocking Antibodies Shigenori GOTO Department of Obstetrics and Gynecology, Niigata University School of Medicine (Director: Prof. Shoshichi

More information

B5 H1 H5 H2 H1 H1 H2 H4 H1 H2 H5 H1 H2 H4 S6 S1 S14 S5 S8 S4 S4 S2 S7 S7 S9 S11 S1 S14 S1 PC S9 S1 S2 S3 S4 S5 S5 S9 PC PC PC PC PC PC S6 S6 S7 S8 S9 S9 S5 S9 S9 PC PC PC S9 S10 S12 S13 S14 S11 S1 S2

More information

1 ) Birnberg et al; Am. J. Obst. Gyn., 54 :88E 1947. 2) Bromberg, Y.M. & Bercovici, B. : Acta Endocrin., 7; 71, 1956. 23 : 33, 1956; Fertil. and Steril. 3) Fluhmann, C. F. : The management of menstrual

More information

-March N ~......... : National Statistical Office,n.d., Population & Housing Census Whole Kingdom National Statistical Office,, Population & Housing C

-March N ~......... : National Statistical Office,n.d., Population & Housing Census Whole Kingdom National Statistical Office,, Population & Housing C joint family : -March N ~......... : National Statistical Office,n.d., Population & Housing Census Whole Kingdom National Statistical Office,, Population & Housing Census Whole Kingdom National Statistical

More information

MM0506-Ariyoshi.ind

MM0506-Ariyoshi.ind 51 2005133 Six years of experiences at the U.K. MRC Laboratories, The Gambia, in West Africa Koya ARIYOSHI 130 1965 1992 Jonathan Weber Medical Research Council MRC Laboratories, The Gambia HIV Virologist/Immunologist

More information

4 8 6 1 1 4 8 2001, 3 2 Marshall [1890]1920, 240 19 1 2001 2008 1990 1997 2007 2 Marshall [1890]1920

4 8 6 1 1 4 8 2001, 3 2 Marshall [1890]1920, 240 19 1 2001 2008 1990 1997 2007 2 Marshall [1890]1920 8 2011. 3 199 213 D. H. D. H. 1877-1953 The Evolution of Industry 1911 1904 1908 1919 1922 45 1906 Industrial Combination 2009 20 4 8 6 1 1 4 8 2001, 3 2 Marshall [1890]1920, 240 19 1 2001 2008 1990 1997

More information

名称未設定-1

名称未設定-1 Study on Clinical Factors Affecting the Fungal Culture Test - Relevance of Dry Mouth - Yoshiko YAMAMURA, Yukihiro MOMOTA, Hideyuki TAKANO, Koichi KANI, Katsumi MOTEGI, Fumihiro MATSUMOTO, Masayuki AZUMA

More information

A comparison of abdominal versus vaginal hysterectomy for leiomyoma and adenomyosis Kenji ARAHORI, Hisasi KATAYAMA, Suminori NIOKA Department of Obstetrics and Gnecology, National Maizuru Hospital,Kyoto,

More information

13:00 13:1513:25 13:2514:40 14:5015:35 15:4516:45 16:4516:50 i 2 AF ii 3 AF AF I 1 1 iii AF (+)- 1. AF +++ +++ +++ +++ +++ +++ + AF I AF II AF III 1. AF AF I AF IIAF I 1. 2. 植 物 病 原 糸 状 菌 のゲノム 解 析 法

More information

喘息について\(公健協会宛02-5作成\)

喘息について\(公健協会宛02-5作成\) Q & A Q & A 1.? 20 2. 1) 2) 3) 4) 5) 6) 7) 1) 2) 3) 4) 5) 6) 7) 8) 9) 3. NHK ( ) 4 10 1 200mg ( ) ( 1 ) 4. ( ) ( ) 5. ( ) ( ) 6. β 2 ( ) 7. ( ) 1 8. 1. 2. 3. 4. 5. 6. 7. 8. 9. 2 5 7 1. 1 10 1) 2) 3) 30

More information

437“ƒ

437“ƒ et al., et al., et al., et al., et al., et al., 2 et al., et al., et al., Lancet Pharmacol Res. et al. Jpn J Cancer Res. et al. Jpn J Cancer Res. et al. Tohoku J Exp Med. et al. Jpn Circ J. et al. Cancer

More information

process of understanding everyday language is similar, finally as far as word production is concerned, individual variations seem to be greater at an

process of understanding everyday language is similar, finally as far as word production is concerned, individual variations seem to be greater at an Understanding of Language in Early Development ( ) Research by Visiting Home (3) Center of developmenta1 education and research Center of developmenta1 education and research Center of developmenta1 education

More information

日本職業・災害医学会会誌第51巻第5号

日本職業・災害医学会会誌第51巻第5号 太田ら 同時多発性高血圧性脳葉出血の 1 手術例 図 1 搬入時 CT 上段 単純 CT 下段 造影 CT 図 2 術後の脳血管撮影検査では明らかな出血源は認めない 379 Reprint request: MULTIPLE SIMULTANEOUS HYPERTENSIVE LOBAR HEMORRHAGE Hirotsugu OHTA M.D. 1) and Akira YOKOTA M.D.

More information

OJT Planned Happenstance

OJT Planned Happenstance OJT Planned Happenstance G H J K L M N O P Q R . %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. .... Q ......... . Planned Happenstance.. pp.- VOL.,NO. pp., Current Status of Ritsumeikan Employees

More information

Various function and toxicity of iron Key words 1) Hentze, M. W. et al: Cell, 117, 285-297 (2004) 2) Ganz, T.: Blood, 102, 783-788 (2003) 3) Nemeth, E. et al.: Science, 306, 2090-2093 (2004) 4) Hentze,

More information

) 2) , , ) 1 2 Q1 / Q2 Q Q4 /// Q5 Q6 3,4 Q7 5, Q8 HP Q9 Q10 13 Q11

) 2) , , ) 1 2 Q1 / Q2 Q Q4 /// Q5 Q6 3,4 Q7 5, Q8 HP Q9 Q10 13 Q11 2009 0612001. 1) 2) 2 2009 3 2009 8, 10 1 3, 12 50 4) 1 2 Q1 / Q2 Q3 910203040 5060708090 Q4 /// Q5 Q6 3,4 Q7 5,6711 123 4 Q8 HP Q9 Q10 13 Q11 , A 5 2 3 3 3 3 3 2 8 5 3 3 4 A C B 1 1 KJ 1 9 1 12 12 15

More information

041-057_’¼Œì

041-057_’¼Œì 542012 4157 Nishino Toshiaki The purpose of this paper is to analyze the present conditions of the mountain villages of Japan in the early 21 st century. The revolution of fuel sources from a predominance

More information

1) a) b) CRP c) d) e) a,b b,c c,d d,e a,e b,d 2) CKD a) ACE ARB b) 2mg/dL ACE ARB c) 2mg/dL d) e) ACE ARB a,b b,c c,d d,e a,e b,d 3) a) 130/85mmHg b)

1) a) b) CRP c) d) e) a,b b,c c,d d,e a,e b,d 2) CKD a) ACE ARB b) 2mg/dL ACE ARB c) 2mg/dL d) e) ACE ARB a,b b,c c,d d,e a,e b,d 3) a) 130/85mmHg b) 2010.1.13 1) 4) 2 18 1) 1 2 3 4 2) 1 2 85 3 3) 1 metabolizer 2 metabolizer 3 metabolizer 4 metabolizer 4) CYP 1 2 metabolizer 3 metabolizer 4 5 6 4 7 2 5 (PPI) 1 2 PPI 2 3 2 3 3 3 3 PPI 3 1 ph 4 5 1) 5)

More information

- March

- March Grzegorz W. Ko odko TIGER - March - March - March - March - March - March - March - March - March Economist - March - March Economist - March PlanEcon - March - March - March - March - March

More information

Tsuken Technical Information 1

Tsuken Technical Information 1 March 2004 Vol.6 Tsuken Technical Information 1 Since microprocessors (MPUs) first appeared in the 1970s, they have developed at a remarkable pace, and now found in a huge range of devices that we use

More information

研修コーナー

研修コーナー l l l l l l l l l l l α α β l µ l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l

More information

:. SPSS

:. SPSS Title 被 服 製 作 に 関 する 知 識 と 技 能 の 実 態 : 帰 国 生 と 一 般 生 と の 比 較 ( fulltext ) Author(s) 山 崎, 真 澄 ; 池 﨑, 喜 美 惠 Citation 東 京 学 芸 大 学 紀 要. 総 合 教 育 科 学 系, 64(2): 175-182 Issue Date 2013-02-28 URL http://hdl.handle.net/2309/132633

More information

12021108_07.indd

12021108_07.indd 雯 A Study of Japanese Time Adverbs Focusing on Adverbs that Express Immediacy Wen - Shun CAIANG Tamkang University of Taiwan This study focuses on adverbs that express immediacy : sugu, sikyuu, tadachini,

More information

揃 24 1681 0 20 40 60 80 100 0 21 42 63 84 Lag [hour] Lag [day] 35

揃 24 1681 0 20 40 60 80 100 0 21 42 63 84 Lag [hour] Lag [day] 35 Forecasting Model for Electricity Consumption in Residential House Based on Time Series Analysis * ** *** Shuhei Kondo Nobayasi Masamori Shuichi Hokoi ( 2015 7 3 2015 12 11 ) After the experience of electric

More information

semen quality or those without WBC in semen. In the patients with azoospermia and normal FSH levels (normogonadotropic azzospermia), the antibody (IgG

semen quality or those without WBC in semen. In the patients with azoospermia and normal FSH levels (normogonadotropic azzospermia), the antibody (IgG CLINICAL STUDIES OF UROGENITAL INFECTIONS WITH CHLAMYDIA TRACHOMA TIS Report 2. The Epidemiology of Chlamydial Infections in Okayama District in Japan and Detection of Antibodies to Chlamydiae in the Sera

More information

p _08森.qxd

p _08森.qxd Foster care is a system to provide a new home and family to an abused child or to a child with no parents. Most foster children are youngsters who could not deepen the sense of attachment and relationship

More information

or or 100,261 76.96 55.04 18,234 77.55 58.74 12,150 57.27 25.25 14,354 95.12 81.69 8,270 92.38 79.36 4,168 84.82 58.88 5,569 83.80 61.55 4,204 55.48 19.57 11,671 25.3 6.7 5 5 10 12 10 1 10 9 30 10

More information

11塩田勉.indd

11塩田勉.indd 論 文 藤 枝 静 男 田 紳 有 楽 塩 田 勉 Fujieda Shizuo, DenshinYuraku The Horizon of Impostors Mystic Vision SHIODA Tsutomu Abstract Fujieda Shizuo wrote a novel dealing with his private life with realistic description

More information

口腔癌の早期発見のために For the early detection of oral cancer Kazumasa Sugihara Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and M

口腔癌の早期発見のために For the early detection of oral cancer Kazumasa Sugihara Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and M Title 口腔癌の早期発見のために Author(s) 杉原, 一正 Citation 鹿児島大学歯学部紀要, 34: 3-11 Issue Date 2014 URL http://hdl.handle.net/10232/20682 http://ir.kagoshima-u.ac.jp 口腔癌の早期発見のために For the early detection of oral cancer Kazumasa

More information

2

2 2011 8 6 2011 5 7 [1] 1 2 i ii iii i 3 [2] 4 5 ii 6 7 iii 8 [3] 9 10 11 cf. Abstracts in English In terms of democracy, the patience and the kindness Tohoku people have shown will be dealt with as an exception.

More information

J53-01

J53-01 53 Bulletin of Hiroshima Jogakuin University : 126Dec. 2003 1 TAT 200310 Object relations in TAT analysis Kyoko YAMASHITA Abstract I carried out TAT with 54 female university students as subjects, and

More information