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1 134 07ｨｺ08ｨ 07ｨｪ09ｨｹｨｺｨｨｨｦ ｨｪ02ｨｦ ｨｮ ﾂｨｪｨｨｨｦ 03ｨｮ08ｨｪｨ 05, 014, ｨｰｨ ｨｰｨｰ ｨC018.46(048.8): 616ｨC : ｨC ｨｰ02ｨｪ02ｨｨｨ 05ｨｹｨｪｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 06ｨ ｨ ｨｺｨｨ09ｨ 06ｨｴｨｨ01 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨ0602ｨｨｨｰ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06ｨｬ 0502 ﾂ02ｨｪｨｨｨｨ ｨ 0302ｨｪｨｨ ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ ｨｬｨ ｨ 0506ｨｺ , 0502ｨｬ02ｨｪ0609ｨ , 08ｨｬｨｨｨｪ09ｨｺｨｨｨｦ , ｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｪ02ｨｦ080601ｨｨ08ｨｮ0800ｨｨｨｨ ｨｨｨｬ. ｨ ｨｺｨ ｨｬ0601ｨ ｨｪ0609ｨ ｨｺ08ｨ ｨｨｨｪ04, ｨｨ0209, 07ｨｺ08ｨ ｨｨｨｪｨ 04ｨ 0909ｨｬ06ｨｰ0802ｨｪ ｨｬ02ｨｪｨｪ ｨｰｨ ｨｪｨｨ ｨｨ09ｨｰ06ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨｦ09ｨｰ09ｨ 01 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨ ｨ ｨｺｨｨ09ｨ 06ｨｴｨｨ ｨｨ0602ｨｨｨｰ0609 (020201) ｨｬ0502ｨｺ0607ｨｨｨｰｨ 06ｨｴｨｨ ﾂｨｨｨｰ0409ｨ 07 09ｨ 03ｨｪｨｮ ｨｹ ｨｺ0502ｨｰ06ｨｺ 05ｨｰ ｨｰｨｨ07ｨ 09 ｨｪｨ 0708ｨ ｨｪｨｨｨｨ ｨｰｨ ｨｪ02ｨｦ08ｨｨｨｰ ｨｪ090608ｨｪ0401 ｨｪ02ｨｦ0806ｨｪ ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨｨｰ0205ｨｨ07 ｨｨ 06ｨ ﾂ02ｨｪｨｨｨｨ ｨｨ ｨ 09ｨｰｨ ｨｪｨｨ07 09 ｨｰｨｺｨ ｨｪｨｹ 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ06ｨｦ 05ｨｮｨｺ0609ｨｨ0204, 09 05ｨｺ ｨｨｨｬ02ｨｪｨｰ02 ｨｨ04ｨｮ ﾂ02ｨｪ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ ｨｺｨｰｨｨ0904 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｰｨ ｨｪ ｨｪｨｨ ｨｨｨｬ0609ｨｰｨｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ ﾂ ｨ : 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪｨ 07 05ｨｮｨｺ0609ｨｨ02ｨ, 06ｨ ｨ ｨｺｨｨ09ｨ 06ｨｴｨｨ02 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨ0602ｨｨｨｰ04, ｨｪ02ｨｦ ｨｪｨｪ ｨｰ ｨｺ0502ｨｰｨｺｨｨ, ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ07 ｨｺ0502ｨｰ06ｨｺ, ｨｰ08ｨ 09ｨｬｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｪ09ｨｰ090609ｨ ｨｪｨｨ02 ｨｬ02ｨｰ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ ﾂ02ｨｪｨｨ ｨｪｨｨ ｨｨｨｪｨｪ ｨｬ060400ｨ 01ｨｨｨｺｨｰｨｮ02ｨｰ ｨｪ0206ｨ ｨｨｨｬ0609ｨｰｨｹ 0904ｨ 0608ｨ ｨｺｨｰｨｨ09ｨｪ0401 ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺ0609 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｬｨ ｨｰ0208ｨｨｨ 05ｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ. 0201ｨｪｨｨｨｬ ｨｨ04 ｨｪ ｨｰ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ 0709ｨｨ05ｨ 09ｨｹ 05ｨｺ ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪｨ 07 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨ ｨ ｨｨｨｬ02ｨｪ02ｨｪｨｨ ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｰ08ｨ ｨｺｨｰｨ, ｨｺ06ｨｰ060804ｨｦ 09ｨｺ0506 ﾂｨ 02ｨｰ ｨｮ050702ｨｨｨｨ ｨｪ02ｨｦ ｨｪｨｪ ｨｰ ｨｺ0502ｨｰ06ｨｺ (010508) ｪ 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ06ｨｦ 05ｨｮｨｺ0609ｨｨ0204 (0209) ｨｨ 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ06ｨｦ 0406ｨｪ04 ｨｪｨ 04ｨ 05ｨｹｨｪ ｨｨｨｰ0205ｨｨ ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨ 0909ｨｬｨ ｨｰ08ｨｨ09ｨ 06ｨｰ ｨｺｨ ｨｺ ｨｮｨ 08 ｨｪ02ｨｦ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ, ｨｺ06ｨｰ ｨｬｨｨ0008ｨｨ08ｨｮ06ｨｰ 09 ｨｪ0202 ｨｨ04 09ｨｮｨ 0902ｨｪｨｰ08ｨｨｨｺｨｮ050708ｨｪ06ｨｦ 0406ｨｪ04 ｨ 06ｨｺ ｨｮ0106 ﾂｨｺ ｨｮ06ｨｴ02ｨｦ 01ｨｨ ｨｪ02ｨｨ080609ｨｺ06ｨｦ ｨｪ02ｨｦ080602ｨｨｨｰ04 [25, 38] ｨ 00ｨ 06ｨｰ, ﾂｨｰ06 08ｨ 04ｨｬｨｪ060302ｨｪｨｪ ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ ｨｪ02ｨｦ ｨｪｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 0209 ｨｨ05ｨｨ ｨｨ ｨｪ02ｨｨ080609ｨ ｨｪｨｪ ｨ ｨｬｨｨｨｪ020800ｨｨ ﾂ0209ｨｺｨｨ02 ｨｪ02ｨｦ0806ｨｪ04 ｨｬ0600ｨｮｨｰ ｨ 04ｨｰｨｹ ｨｨ ｨｹ040609ｨ ｨｪ ｨ ｨｮｨｰ06ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ, ｨｪｨ 0708ｨｨｨｬ0208, 0708ｨｨ 0502 ﾂ02ｨｪｨｨｨｨ 07ｨ 08ｨｺｨｨｨｪ0906ｨｪｨｨ04ｨｬｨ ｨｬ02ｨｪ ｨｺｨｰｨｨ09ｨｪ04ｨｬ ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺ06ｨｬ ｨｮ- ﾂ02ｨｪｨｨ07 ｨｪ02ｨｦ0806ｨｺ0502ｨｰ06ｨｺ ｨ ｨｬ0209ｨｰｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ ｨｰ ｨｨ000208ｨｨ ﾂ0209ｨｺｨ 07 ﾂｨ 09ｨｰｨｹ 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨ ｨｪｨ 05ｨｨ04ｨ ｨｰ0608ｨ ｪ 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪｨ ｨｪｨ ｨｪｨ 04ｨ 05ｨｹｨｪ ｨｨｨｰ0205ｨｨ ｨｬ02ｨｪｨｪ04ｨｬ ｨｰｨ ｨｪｨｨ07ｨｬ, ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨｨｰ0205ｨｨ07 01ｨ 06ｨｰ ｨｪｨ ﾂｨ ｨｪ090608ｨｪ04ｨｬ ｨｪ02ｨｦ0806ｨｪｨ ｨｬ, ｨｨ09ｨ 06ｨｴｨｨｨｬ ｨｺ0502ｨｰｨｺｨ ｨｬ, ｨ ｨｰｨ ｨｺ [2], ｨｺ06ｨｰ ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｨ08ｨｮ06ｨｰ0907 ｨｰ06ｨｪｨｺｨｨｨｬｨｨ 02ｨｨｨｰ060705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ 06ｨｰ080609ｨｰｨｺｨ ｨｬｨｨ, 06ｨｺｨｮｨｰ0409ｨ 06ｨｴｨｨｨｬｨｨ ｨ ｨｺ0906ｨｪ ｨｪ090608ｨｪ0401 ｨｪ02ｨｦ0806ｨｪ ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨｨｰ0205ｨｨ07 ｨｪｨ ｨｬ ｨｰ070302ｨｪｨｨｨｨ ｨ 09ｨｰｨ ｨｪｨｨ ｨｬ0208ｨｮ050708ｨｪ04ｨｦ ｨｦ 0209 [28]. 06ｨｰｨｨ ｨ 08ｨ 04ｨｪ ｨｨｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ, ｨｨ09ｨ ｨｪｨｪ0402 Golgi ｨｨ Blanes 09 ｨｺ06ｨｪ0202 XIX 09ｨｰ060502ｨｰｨｨ07 ｨｨ ｨｮ ﾂｨｨ0903ｨｨ02 ｨｪｨ 0409ｨ ｨｪｨｨ02 ｰｨ 0502ｨｦｨｪ ｨｺ06ｨｦ 0005ｨｨｨｨ ｱ [31], ｨｨｨｰ0205ｨｹｨｪ ｨｨ ｨｰ ｨｨ04 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨ ｨｺ ｨ ｨ ｨ 00ｨ 06ｨｰ0907 ｨｺｨ ｨｺ ｨｪｨｰｨｪ ｨｺ06ｨｪ 0209, ｨｰｨ ｨｺ ｨｨ 09 ｨ ｨ 04ｨ 05ｨｹｨｪ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ02 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨｨｰ0205ｨｨ07 [9, 22, 31] ｨ ｨ 04ｨ 05ｨｹｨｪ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ04 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨｨｰ0205ｨｨ07 06ｨｰ05ｨｨ ﾂｨ 06ｨｰ0907 ｨ ｨ 0302ｨｪｨｪ06ｨｦ ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 ｨｨ ｨｬｨｨ0008ｨ 02ｨｨ06ｨｪｨｪ06ｨｦ ｨ ｨｪ0609ｨｰｨｹ06 in vitro [33]. 07 ﾂｨｨｨｰ0409ｨ 07, ﾂｨｰ06 ｨｪ02ｨｦ0806ｨｪ060002ｨｪ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 06ｨｰ010205ｨ 01 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨ ｨｪｨ 05ｨｨ04ｨ ｨｰ0608ｨ ｨｨ ｨｨｨｰ ｨｪｨ ｨｰ070302ｨｪｨｨｨｨ ｨｦ 03ｨｨ04ｨｪｨｨ ﾂ ｨｺｨ, , ｨｨ01ｨｨｨｬ06ｨｬｨｮ, ｨｮ02ｨｰ 08ｨ 0909ｨｬｨ ｨｰ08ｨｨ09ｨ ｨｰｨｹ ｨｺｨ ｨｺ 0201ｨｨｨｪ09ｨｰ0902ｨｪｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ ﾂ ｨｺｨ, 06ｨ ﾂｨｨ09ｨ 06ｨｴｨｨ02 ｨｪｨ 0708ｨ ｨｪｨｪ04ｨｦ ｨｰ ｨｬ ｨ ｨｺ0906ｨｪ ｨｪｨｮ 0902ｨｴ0209ｨｰ09ｨ ｨｬ060400ｨ. 06ｨｰｨ ｨ 02ｨｪｨｪ0609ｨｰｨｹ ｨｮ03ｨｨ05ｨ 0609ｨｪ0609ｨ ｨｪｨｨ02ｨｬ ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ ｨｨ04ｨｮ ﾂ02ｨｪｨｨ07 ｨｨ ｨｦ09ｨｰ09 ｨｨ ｨｪｨｨｨｰ0608ｨｪ ｨｰ02ｨｪ02ｨｨｨ 05ｨ, ｨ ｨｰｨ ｨｺ ｨｪｨｺｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ ｨｨｨｬ02ｨｪ02ｨｪｨｨ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06ｨｬ 0502 ﾂ02ｨｪｨｨｨｨ ｨｪｨｨ ｨｨｨｪｨｪ ｨｬ060400ｨ. 0608ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ ｨｰｨ ｨｪ ｨｪｨｨ ｨｨｨｪｨｪ ｨｬ060400ｨ 0708ｨｨ ｨｰ08ｨ 09ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｬ ｨｪｨｨｨｨ. 00 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨｺ ｨｨｨｬ02ｨｪｨｰ02 ｨ ｨｺｨｰｨｨ09ｨｪ06 ｨｨ04ｨｮ ﾂｨ 02ｨｰ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ ｨｰｨ ｨｪ ｨｪｨｨ ｨｨｨｬ0609ｨｰｨｨ ｨｪｨｪ0401 ｨｪ020809ｨｪ ｨｺ06ｨｪ 0708ｨｨ ｨｬ0201ｨ ｨｪｨｨ ﾂ0209ｨｺ06ｨｦ ｨｰ08ｨ 09ｨｬ ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ A. Ramon-Cueto ｨｨ 0906ｨ 09ｨｰ [32] ｨｬ ｨｨ080609ｨ 05ｨｨ ｨ ｨｪｨ ｨｰ06ｨｬｨｨ ﾂ0209ｨｺｨｨｨｦ 08ｨ ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｺ ｨｮｨｰ02ｨｬ ｨｮ01ｨ 0502ｨｪｨｨ ｨｬ02ｨｪｨｰｨ TIX. 07 ﾂｨ 09ｨｰ06ｨｺ ｨｪｨｨ07 06ｨｺｨｮｨｰ0409ｨ 05ｨｨ ｨｬ ｨｨｨｪｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨｨ ｨｨ05ｨｨ ｨｺｨ ｨｺ 09 06ｨ 08ｨ ｨ 0903ｨｨｨｦ ｨｺｨｰ, ｨｰｨ ｨｺ ｨｨ 09 09ｨｬ0203ｨｪｨｮ06 ｨｰｨｺｨ ｨｪｨｹ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ ｨｨ 01ｨｨ09ｨｰｨ 05ｨｹｨｪ ｨｮ ﾂｨ 09ｨｰｨｺ ｨｨｨｪｨｪ ｨｬ060400ｨ.

2 130306ｨｰ02ｨｪ02ｨｨｨ 05ｨｹｨｪｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 06ｨ ｨ ｨｺｨｨ09ｨ 06ｨｴｨｨ01 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨ0602ｨｨｨｰ0609 ｭ ｨｰｨ ｨｪ ｨｪｨ ｨｪ0208ｨ 02ｨｨ07 ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ ｨｺ06ｨｪ- ﾂｨ ｨｪｨｨｨｦ ｨｪ02ｨｦ0806ｨｪ ｨｰ08ｨ 05ｨｹｨｪ06ｨｬ ｨｨ ｨｺｨ ｨｮ01ｨ 05ｨｹｨｪ06ｨｬ ｨｪｨ 0708ｨ ｨｪｨｨ0701 ｨｪｨ 08ｨ 0909ｨｰ0607ｨｪｨｨ02 06ｨｺ ,5 09ｨｬ 06ｨｰ ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ01 ｨｺ08ｨ 0209 ｨｺｨｮ05ｨｹｨｰ02ｨｦ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨ 09ｨｰｨ ｨｪｨｨ02ｨｬ ｨｪ02ｨｦ08ｨｨｨｰ0609 ﾂ ｨｨｨｪｨｨｨｰ0205ｨｹｨｪ06ｨｰｨｺｨ ｨｪｨｪｨｮ06 06ｨ ﾂｨｺｨｮ ｨｺｨｰｨ. N. Keyvan-Foulad06 ｨｨ 0906ｨ 09ｨｰ [15] ｨｨ ｨｹ040609ｨ 05ｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ06 09ｨｮ090702ｨｪ04ｨｨｨｨ ｨｪｨｪ04ｨｦ ｨｮ ﾂｨ 09ｨｰ06ｨｺ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｺ080409, ｨｮ ｨｺ06ｨｰ ﾂ ｨｬ ｨｬ ｨｨ080609ｨ ｨｪｨｨ07 ｨｰ08ｨ 09ｨｬ04 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｰｨ ｨｪ ｨｪｨｨ02 ｨｪ02 06ｨｰｨｬ02 ﾂ02ｨｪ ｨｰ02 ﾂ02ｨｪｨｨ02 1 ｨｪ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｮ 03ｨｨ0906ｨｰｨｪ0401 ｨｮ05ｨｮ ﾂ03ｨ ｨｹ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨｨ080609ｨ ｨｪｨｨ02 ｨｨ0709ｨｨ05ｨ ｨｰ0208ｨ 05ｨｹｨｪ ｨｰｨｪ060302ｨｪｨｨ06 ｨｺ 0406ｨｪ ｨ 0302ｨｪｨｨ07 ｨｺ06ｨｪ02 ﾂｨｪ0609ｨｰ02ｨｦ. 05 ｨｨ ｨｹ040609ｨ ｨｪｨｨ02ｨｬ ｨｬ02ｨｰ0601ｨ ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ ｨｰ08ｨ ｨｪ ｨｰｨ ｨｬ060502ｨｺｨｮ05 ｨ ｨｨ06ｨｰｨｨｨｪ0102ｨｺ09ｨｰ08ｨ ｨｪｨ ｨｮ09ｨｰｨ ｨｪ ｨｪ06, ﾂｨｰ ｨｪｨｪ0402 ｨ ｨｺ0906ｨｪ04 ｨｺ0608ｨｰｨｨｨｺ060907ｨｨｨｪｨ 05ｨｹｨｪ ｨｰ08ｨ ｨｺｨｰｨ 06ｨ 08ｨ 04ｨｮ06ｨｰ ｨｬ0609ｨｰｨｨｨｺｨｨ ﾂ ｨｪｨｮ ｨｪｨｨ07, ｨ 09ｨｰｨ 06ｨｰ 09 ｨｺｨ ｨｮ01ｨ 05ｨｹｨｪ06ｨｬ ｨｪｨ 0708ｨ ｨｪｨｨｨｨ ｨｪｨ 08ｨ 0909ｨｰ0607ｨｪｨｨ ｨｬｨｬ ｨｨ 04ｨ ｨｺｨ ｨｪ ﾂｨｨ09ｨ 06ｨｰ ｨ ｨｰ090502ｨｪｨｨ07ｨｬｨｨ ｨｬ 0902ｨｴ0209ｨｰ ｨｨｨｪｨｪ ｨｬ060400ｨ. 0308ｨｨ 05ｨｰ06ｨｬ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ04ｨｦ ｨｺｨｰ ｨｰｨ ｨｪ ｨｪｨｨ07 ｨｪｨ ｨ ｨ 05ｨｨ ｨｮ ｨｨ ｨｪ0208ｨ 02ｨｨｨｨ 1% ｨ ｨｺ0906ｨｪ0609 ｨｺ0608ｨｰｨｨｨｺ060907ｨｨｨｪｨ 05ｨｹｨｪ ｨｰ08ｨ ｨｺｨｰｨ, ﾂｨｰ ｨｰ ｨ 02ｨｰ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0402 ｨｺ06ｨｬ0702ｨｪ09ｨ ｨｰ0608ｨｪ ｨｬ0603ｨｪ0609ｨｰｨｨ ｨｪ020809ｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ ｨｮｨｪ0609 [15]. 00.I. Chuah ｨｨ 0906ｨ 09ｨｰ [7] ｨｨ ｨｹ040609ｨ 05ｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｪｨｮ ｨｪｨｨ ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｺ ｨｺｨｨ ｨ 05ｨｹｨｪ ｨｰ0605ｨ 0609 ｨｪｨ ｨｮ080609ｨｪ02 TVIIIｨCTIX ｨｺｨ 0709ｨｮ0504 ｨｨ ｨｨ09ｨｰ ｨｨｨｬ0208ｨ, ｨｪｨ ｨｪ02ｨｪｨｪ ﾁ ｨｪ0201 ｨ 09ｨｰ ｨ ｨｪｨ 08ｨｮ03ｨｨ05ｨｨ 0601ｨｨｨｪ06 ﾂｨｪ ｨｪ0208ｨｨ08ｨｮ06ｨｴｨｨ02 ｨ ｨｺ0906ｨｪ04, 08ｨ ｨｪｨｪ ｨ 05ｨｨ04ｨｨ ｨｺｨ 0709ｨｮ ｨｰ05ｨｨ- ﾂｨｨ02 06ｨｰ 05ｨｰ060006, 0708ｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨ 0204 ｨｪ0609ｨｨｨｰ ｨｪｨ ｨ ｨ 05ｨｨ 06ｨ 08ｨ ｨ ｨｪｨｨ02 ｨｺ060505ｨ ｨｰ0208ｨ 05ｨｹｨｪ ｨ ｨｰ090502ｨｪｨｨｨｦ ｨｺ06ｨｪ ｨｨｨｪｨｰｨ ｨｺｨｰｨｪ ｨｪｨｰ08ｨ 05ｨｹｨｪ ｨｺ0608ｨｰｨｨｨｺ060907ｨｨｨｪｨ 05ｨｹｨｪ ｨｰ08ｨ ｨｺｨｰｨ 09 ｨｪｨ 0708ｨ ｨｪｨｨｨｨ ｨｮ ﾂｨ 09ｨｰｨｺｨ ｨｪｨｨ07 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ ｨｰｨ ｨ ｨｪｨｪ04ｨｬ M.W. Richter ｨｨ 0906ｨ 09ｨｰ [33], ｨ ｨ 04ｨ 05ｨｹｨｪ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ04 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨｨｰ0205ｨｨ ｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｪｨｮ ｨｮｨｪｨｨ05ｨ ｨｰ0208ｨ 05ｨｹｨｪ ｨｪｨｨ07 04ｨ 01ｨｪ02ｨ 06ｨｺ ｨｰ ｨ ｨｴ0209ｨｰ09ｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｰ ｨｪｨｪｨｮ ｨ ｨｪ0609ｨｰｨｹ ｨｺ ｨｬｨｨ0008ｨ 02ｨｨｨｨ, 09ｨｰｨｨｨｬｨｮ050702ｨｨｨｨ ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ ｨｰｨ ｨｨ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ06 08ｨ 04ｨｬ ｨｪ04 ｨｮ03ｨｨｨ ｨ. J. Lu ｨｨ 0906ｨ 09ｨｰ [21] 0106ｨｺｨ 04ｨ 05ｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｹｨｪ0401 ｨ 0506ｨｺ0609 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 0406ｨｪ04 ｨｪｨ 04ｨ 05ｨｹｨｪ ｨｨｨｰ0205ｨｨ07 ｨｺ ｨｨ ｨｰｨ ｨｪ ｨｪｨｨｨｨ ｨ ｨｪｨ ｨｰ06ｨｬｨｨ ﾂ0209ｨｺ ｨ ｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ. 0201ｨｪｨ ｨｺ06 ｨｪ02 ｨｮ09ｨｰｨ ｨｪ ｨｪ06, 04ｨ 09 ﾂ02ｨｰ ｨｺｨ ｨｺｨｨ01 ｨｨｨｬ02ｨｪｨｪ06 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｬ02ｨｪｨｰ0609 ｨ ｨｰｨｨ00ｨｪｨｮｨｰ ｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨｺｨｰ. 0201ｨｪｨｨｨｬ ｨｨ ｨｪｨｨｨｦ ｨｰ ｨｬ0603ｨｪ0609ｨｰｨｹ 01ｨｨ ｨｪ02ｨｨ080609ｨｺｨｨ ｨｪｨｨｨｰ ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨｨｰ0205ｨｨ ｨｨ 05ｨｺ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ 05ｨｹｨｪ0401 ｨｮ ｨｨ0701 ｨｨ05ｨｨ ｨｨ01 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｪｨｮ 08ｨ ｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ [21, 38]. 01. Huang ｨｨ 0906ｨ 09ｨｰ [13] ｨｨ ｨｺ05ｨｨｨｪｨｨ- ﾂ0209ｨｺ0602 ｨｨ ｨ ｨｪｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ﾂ02ｨｪｨｨｨｨ 0907ｨｨｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ08ｨ 09ｨｬ ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ ｨｮｨｴ0209ｨｰ ｨｨ ｨｬ ｨ ｨｰｨｨ09ｨｪ ｨｬ0203ｨ ｨｰ0205ｨｹ09ｨｰ09, ｨｮ09ｨｬｨ ｨｰ08ｨｨ09ｨ 06ｨｴｨｨ01 ｨｮ09ｨｰ08ｨ ｨｪ02ｨｪｨｨ02 ｨｺ06ｨｬ ｨｨｨｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｨ 09ｨｰｨ ｨ ｨｨ05ｨｨ04ｨ 02ｨｨ ｨｪ06 ﾂｨｪｨｨｨｺｨ. 02ｨｰｨｬ02 ﾂ02ｨｪ06 ｨｪ0204ｨｪｨ - ﾂｨｨｨｰ0205ｨｹｨｪ0602 ｨｮ05ｨｮ ﾂ0302ｨｪｨｨ02 ｨｪ ｨｨ ﾂ0209ｨｺ ｨｰｨ ｨｰｨｮ09ｨ 07ｨ 02ｨｨ02ｨｪｨｰ ｨ 09ｨｰｨｪ ｨｮ ｨｨ01ｨｨｨｬ06ｨｬｨｮ, ｨｪｨｪ ｨｪｨ ﾂ02ｨｪｨｨ02 ｨｨｨｬ0205ｨ 0105ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨｨ0601ｨ ｨｬ020301ｨｮ ｨｪｨｨｨｺｨｪ060902ｨｪｨｨ02ｨｬ ｨｰ08ｨ 09ｨｬ04 ｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ02ｨｦ ｨ ｨｪｨｪ04ｨｬ J.E. Collazos-Castro ｨｨ 0906ｨ 09ｨｰ [8], ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ ｨｺ ｨｨｨｬ02ｨｪｨｰ02 06ｨｺｨ 04ｨ 05ｨ 09ｨｹ ｨｪ ｨｺｨｰｨｨ09ｨｪ06ｨｦ 0708ｨｨ ｨｰ08ｨ 09ｨｬ ｨｦｨｪ ｨｰ ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｺ (ｨｮ03ｨｨｨ ｨｪｨ ｨｮ080609ｨｪ ｨｬ02ｨｪｨｰｨ 05VII) ｨｨ ﾂｨ 09ｨｰ ｨ 05ｨ 09ｨｹ ｨ ｨｪ06ｨｬｨ 05ｨｹｨｪ04ｨｬ ｨｰ06ｨｬ ｨ ｨｺ0906ｨｪ ｨ 08ｨ ｨ ｨｪｨｨ02ｨｬ 0702ｨｰ0205ｨｹ. 00ｨｨ0008ｨ 02ｨｨ ｨ ｨｪ ｨｪｨｨ07 ｨｨ05ｨｨ ｨ 09ｨｰｨ ｨｪｨｨ02 ｨ ｨｺ0906ｨｪ0609 ﾂ ｨｮ ﾂｨ 09ｨｰ06ｨｺ ｨｮ03ｨｨｨ ｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｪ02 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ04. V.M. Gomez ｨｨ 0906ｨ 09ｨｰ [12] ｨｨ04ｨｮ ﾂｨｨ05ｨｨ ｨｬ0603ｨｪ0609ｨｰｨｹ ｨｰｨ ｨｪ ｨｪｨｨ ｨｨ ﾂｨｪ0401 ｨ ｨｪｨｰ ｨ 01ｨｪｨｨ ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｺ ｨｺ ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ06ｨｦ DREZ06ｨｰ06ｨｬｨｨｨｨ ｨｪｨ ｨｮ080609ｨｪ02 05IIIｨCTIII 07ｨｮｨｰ02ｨｬ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｪｨｮ ｨｪｨｨ07. 05ｨｰ020702ｨｪｨｹ ｨｪ0208ｨ 02ｨｨｨｨ ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ ｨｺ06ｨｪ ﾂｨ ｨｪｨｨｨｦ ｨｨ ｨｬ06ｨｴｨｹ ｨｰ ｨ 01ｨｪ ｨｬ02 ﾂ02ｨｪｨｨ ｨｪ04ｨｬ ｨｰ06ｨｺ09ｨｨｨｪ06ｨｬ 00, ｨ ｨｰｨ ｨｺ ｨｺ ｨｨｨｨ ｨｰｨｨ01ｨ CGRP ｨｨ 07ｨｮ08ｨｨｨｪ ｨｰ0608ｨ ｨｰ ｨｮ09ｨｰｨ ｨｪ0609ｨｨ05ｨｨ, ﾂｨｰ06 CGRP- ｨｨ P2X ｨｨｨｰ0205ｨｹｨｪ0402 ｨ ｨｺ0906ｨｪ ｨ ｨ ｨ 09ｨｰｨ 05ｨｨ ﾂ ｨｮ ﾂｨ 09ｨｰ06ｨｺ ｨｪｨｨ07, ｨｪ06 ｨｨ09ｨｺ0506 ﾂｨｨｨｰ0205ｨｹｨｪ06 ｨ 05ｨ ｨ ｨｪ0208ｨ 02ｨｨ06 ｨ ｨｺ0906ｨｪ ｨｰ0605ｨｴ ｨ 05ｨｹｨｪ ｨ ｨｪ02 ｨｪｨ ｨ ｨ 05ｨｨ, 0601ｨｪｨ ｨｺ ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ ｨｬ0209ｨｰ02 09 ｨｪ020809ｨｪ04ｨｬｨｨ ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ 0907ｨｨｨｪｨ 05ｨｹｨｪ ｨ ｨｪ0005ｨｨ ｨｰｨｬ02 ﾂｨ 05ｨｨ ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ04ｨｦ ｨｰ ｨｪ02ｨｦ08ｨｨｨｰ0609. Y. Li ｨｨ 0906ｨ 09ｨｰ [19] 0708ｨｨ ｨｰ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｺｨｰｨｨ09ｨｪ ｨｨ ｨｹ040609ｨ ｨｪｨｨ ｨｰｨ ｨｪ ｨｪｨｨ ｨｨｨｪｨｪ ｨｬ060400ｨ DREZ06ｨｰ06ｨｬｨｨｨｨ. 0709ｨｰｨ ｨｪ ｨｪ06, ﾂｨｰ ｨ ﾂｨ 06ｨｰ 0908ｨ 09ｨｰｨ ｨｪｨｨ02 ｨ ｨｺ0906ｨｪ ｨｰｨｺｨ ｨｪｨｹ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ. 00 ｨｰ ｨｬ07, L.M. Ramer ｨｨ 0906ｨ 09ｨｰ [29] ｨｮ09ｨｰｨ ｨｪ0609ｨｨ05ｨｨ, ﾂｨｰ06 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ ｨｨ04 ｨ ｨ 04ｨ 05ｨｹｨｪ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ04 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨｨｰ0205ｨｨ07 ｨｬ0403ｨｨ ｨｪ ｨｰ02ｨｪ02ｨｨ08ｨｮ02ｨｰ ｨ 09ｨｰｨ ｨｪｨｨ02 ｨ ｨｺ0906ｨｪ0609 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0401 ｨｪ02ｨｦ0806ｨｪ ｨｨｨｪｨｪ06ｨｬ ｨｮ ｨｺ DREZ06ｨｰ06ｨｬｨｨｨｨ. 06ｨｰｨｨ ｨｪ02ｨｮ01ｨ ﾂｨｪ ｨｰｨｺｨｨ 06ｨ ｨｮ ｨｨ05ｨｨ ｨｪ0206ｨ ｨｨｨｬ0609ｨｰｨｹ 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ ｨｪ ｨｺ ｨｪｨｨ ｨ 0502ｨｬ04 ｨ ｨｪｨ ｨｰ06ｨｬｨｨ ﾂ0209ｨｺ ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｰｨ ｨｪ ｨｪｨｨ ｨｪｨｪ ｨｨｨｪｨｪ ｨｬ060400ｨ 07ｨｮｨｰ02ｨｬ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ. 06ｨ ｨｺ, ｨ ｨｪｨｨ07 ｨｮ ｨｨｨｦ 0105ｨｨｨｰ0205ｨｹｨｪ ｨｮ ｨｨ09ｨ ｨｪｨｨ07 09ｨｮ090702ｨｪ04ｨｨｨｨ ｨｬ0209ｨｰ ｨｪｨｨ ｨ ｨｰ ｨｨ ﾂ0209ｨｺｨｨｨｦ 06 ﾂｨ ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ07 08ｨ 0408ｨ ｨ ｨ ｨｰ0409ｨ 06ｨｰ ｨｨｨ 05ｨｹｨｪ ｨｨｨｬ0208ｨｪ0402 ｨｪ0609ｨｨｨｰ0205ｨｨ

3 ｨｬｨ ｨ 0506ｨｺ , 0502ｨｬ02ｨｪ0609ｨ , 08ｨｬｨｨｨｪ09ｨｺｨｨｨｦ , ｨｺ0502ｨｰ06 ﾂｨｪ0401 ｨｬｨｨｨｺ09ｨｰ0609 ｨｨ 00ｨ ｨｺｨｰ ｨｰｨ ｨ 00ｨ 06ｨｰ, ﾂｨｰ06 05ｨｰｨｨ 0708ｨｨ02ｨｬ04 ｨ ｨｮ01ｨｮｨｰ ｨ 09ｨｰ090609ｨ ｨｰｨｹ 0607ｨｰｨｨｨｬｨｨ04ｨ 02ｨｨｨｨ ｨｨｨｰ0205ｨｹｨｪ ｨｦ09ｨｰ09ｨｨ ｨｪｨ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ ｨｪ ｨｪｨｨ ｨｨｨｪｨｪ ｨｬ060400ｨ. 04ｨ ｨ 06ｨｰ ｨｰ06ｨｬ ｨｪｨ 0708ｨ ｨｪｨｨｨｨ 09 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ07 ｨ ｨｺｨｰｨｨ09ｨｪ ｨｮｨｰ ｨ 0708ｨｨｨｬ0208, L.N. Novikova ｨｨ 0906ｨ 09ｨｰ [24] ｨｮ09ｨｰｨ ｨｪ0609ｨｨ05ｨｨ, ﾂｨｰ06 ｨ ｨｨ ｨｨｨｬ0208ｨｪ04ｨｦ ｨｬｨ ｨｰ08ｨｨｨｺ09ｨｪ04ｨｦ ｨ 08ｨ ｨｰ, ｨｰ080602ｨｪｨｪ04ｨｦ ｨｪｨ 0609ｨｪ ｨ 05ｨｹ00ｨｨｨｪｨ ｨｰｨｪ ｨｨ ｨｦ ｪ ｨｬｨ ｨｰ08ｨｨ000205ｨｹ ｨｨｨｪ01ｨｮ02ｨｨ08ｨｮ02ｨｰ ｨｬｨ 0909ｨｨ09ｨｪ04ｨｦ ｨ ｨｮｨｰｨｨｨｪ00 ｨｪ02ｨｦ0806ｨｪ ｨｨｨｪｨ 05ｨｹｨｪ ｨ ｨｪ0005ｨｨ0209 in vitro ｨｨ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ ｨｨ 0605ｨｨ ｨｪ ｨｨｨｰ ｨｺｨｰｨｨ09ｨｪ04ｨｬ ｨｬ02ｨｰ060106ｨｬ ｨｰｨ ｨｪ ｨｪｨｨ ｨｪｨｪ ｨｨｨｪｨｪ ｨｬ060400ｨ 09 ﾂｨｨｨｰｨ 06ｨｰ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ ｨｨ 0605ｨｨ ｨｪ ｨｨｨｰ0609 ﾂ ｨｪ ｨｰ08ｨ 09ｨｬ04 ｨｪｨ 0006ｨｪ ｨｪｨｨ07 ｨｬ02ｨｰｨｨ ｨｪｨｨ ｨｪｨ ｨｨ ｨｨｨｪｨｰ ｨｦｨｺｨｨｨｪｨ ｨｰ0806ｨｬ ｨｨ ｨｰ08ｨ 09ｨｬ04 [26] ｨｬｨｪ02ｨｪｨｨ06 ｨｨ ｨ ｨｰ020502ｨｦ, 0607ｨｰｨｨｨｬｨ 05ｨｹｨｪ04ｨｬ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ ｨｰｨ 09 ｨｺｨｮ05ｨｹｨｰｨｮ ｨｰ0907 ｨｨ ｨｹ040609ｨ ｨｪｨｨ ｨｰ ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨ01 ｨｺｨｮ05ｨｹｨｰｨｮ , 09ｨｺ0506 ﾂｨ 06ｨｴｨｨ ｨｨｨｰ0205ｨｹｨｪ0402 ｨｨ ｨｰ08ｨｨ02ｨ ｨｰ0205ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ [16]. 0308ｨｨ 05ｨｰ06ｨｬ 0708ｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｪｨ ｨｬ ｨｨ ｨｬ0201ｨ ｨｪｨｨ ﾂ0209ｨｺ06ｨｦ ｨｰ08ｨ 09ｨｬ ｨｨｨｪｨｪ ｨｬ060400ｨ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨ 09ｨｰ080602ｨｨｨｰｨ 08ｨｪ06ｨｦ 0005ｨｨｨｨ ｨｨ 09ｨｨｨｪｨｰ ｨｪ010806ｨｨｨｰｨｨｨｪ09ｨｮ05ｨｹ00ｨ ｨｰ0609 ｨｬ02ｨｪ ｨ 0302ｨｪ04, ﾂ02ｨｬ ｨｪｨｨ02 ｨｺ0502ｨｰ06ｨｺ 0605ｨｨ ｨｪ ｨｨｨｨ [17] ｨｰ06ｨｬｨｮ K. Fouad ｨｨ 0906ｨ 09ｨｰ [10] ｨ 00ｨ 06ｨｰ ｨｨｨｰｨｹ 09 ｨｮ ﾂｨ 09ｨｰ06ｨｺ ｨｪｨｨ ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｺ06ｨｬ070502ｨｺ ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ 0605ｨｨ ｨｪ ｨｨｨｨ ｨｨ 0106ｨｪ010806ｨｨｨｰｨｨｨｪｨ ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 09 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨｺｨｰｨｨ09ｨｪ04ｨｬ 09ｨ 08ｨｨｨ ｨｪｨｰ06ｨｬ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 0708ｨｨ ｨｰｨ ｨｪ ｨｪｨｨｨｨ ｨｨｨｬ0609ｨｰｨｨ ｨｪｨｪ ｨｨｨｪｨｪ ｨｬ060400ｨ 09 ﾂｨｨｨｰｨ 06ｨｰ ｨｪｨｨ02 ｨｺ0502ｨｰ06 ﾂｨｪ0401 ｨｬｨｨｨｺ09ｨｰ0609 ｨｨ ｨｮｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ01 ｨｰ080600ｨｨ ﾂ0209ｨｺｨｨ01 00ｨ ｨｺｨｰ ｨｺ06ｨｬ070502ｨｺ ｨｨ09ｨｺｨｮ0909ｨｰ0902ｨｪｨｪ04ｨｬｨｨ ｨｨｨｬ0208ｨｪ04ｨｬｨｨ ｨｪ0609ｨｨｨｰ020507ｨｬｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｪｨ ｨｬ ｨｨ ｨｰ08ｨ 09ｨｬ ｨｨ000208ｨｨ ﾂ0209ｨｺ ｨｪ020809ｨ. 0608ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ ｨｬ060302ｨｰ 06ｨｺｨ 04ｨ ｨｰｨｹ ｨｺｨｰｨｨ09ｨｪ06ｨｦ ｨｰｨ ｨｺ ｨｨ ｨｰｨ ｨｪ ｨｪｨｨｨｨ ｨｰｨｪ0609ｨｰｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ S.Y. Cheng ｨｨ 0906ｨ 09ｨｰ [5] ｨｺｨｨ ｨ 05ｨｨｨｴｨｪ ｨｪ020809ｨ 09ｨ 05ｨｨ03ｨ 05ｨｨ ｨｨ 00ｨｨｨｺ09ｨｨ080609ｨ 05ｨｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪｨｮ06 ｨｨ 01ｨｨ09ｨｰｨ 05ｨｹｨｪｨｮ06 ﾂｨ 09ｨｰｨｨ ｨｨ05ｨｨ ｨｰ08ｨ ｨｪ09ｨｰ0906 ｨｬ020301ｨｮ ｨｺｨｮ05ｨｹｨｰ07ｨｬｨｨ ｨｪ020809ｨ ｨｨ ﾂ ｨｨ 90 09ｨｮｨｰ ｨｨ04ｨｮ ﾂｨ 05ｨｨ ｨｺｨｰ08ｨｨ ﾂ0209ｨｺｨｮ ｨｨｨｬ0609ｨｰｨｹ. 0709ｨｰｨ ｨｪ ｨｪ06 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 05ｨ ｨｰ02ｨｪｨｰｨｪ ｨｨ0601ｨ , ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 09ｨｺ ｨｰｨｨ ｨｪｨｨ07 ｨｨ ｨ ｨｬ0705ｨｨｨｰｨｮ ｨｺｨｰ08ｨｨ ﾂ0209ｨｺ ｨ ｨｮ030102ｨｪｨｨ07, ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ HRP ｨｨｨｰ0205ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 05ｨ ｨｰ0208ｨ 05ｨｹｨｪ ｨ ｨｪ ｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｨ ｨｪ020809ｨｪ ｨｺ06ｨｪ ｨｪｨ 0201ｨｨｨｪｨｨ02ｨｮ ｨｴｨ 01ｨｨ ﾂｨｪ ﾂ02ｨｪｨｨ07 ｨｪ020809ｨ, ｨ ｨｰｨ ｨｺ0302 ｨｮｨｰ0605ｨｴ02ｨｪｨｨ02 ｨｬｨｨ0205ｨｨｨｪ ｨ ﾂ02ｨｺ ｨ ｨｺ0906ｨｪ ,63 ｨｬｨｺｨｬ. Y. L06 ｨｨ 0906ｨ 09ｨｰ [20] ｨｨ ｨｹ040609ｨ 05ｨｨ ｨｰｨ ｨｪ ｨｪｨｨ ｨｰｨｪ0609ｨｰｨｨ 0408ｨｨｨｰ0205ｨｹｨｪ ｨｪ020809ｨ ｨｺ ｨｬ ｨｨ080609ｨ ｨｪｨｨ ｨｪ ｨｪｨｮｨｰ08ｨｨ0608ｨ ｨｨｨｰｨ 05ｨｹｨｪ ｨ ｨ. 02 ﾂｨｨｨｴ02ｨｪｨｪ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨｨ080609ｨ 05ｨｨ ｨｬ0203ｨｮｨｰ06ｨｺ ｨｬ020301ｨｮ 09ｨ 05ｨｨ0302ｨｪｨｪ04ｨｬｨｨ ｨｺ06ｨｪ02ｨ ｨｬｨｨ ｨｪ020809ｨ. ﾁ ｨｬ ｨｰｨｨｨｪｨ 05ｨｹｨｪ0402 ｨ ｨｺ0906ｨｪ ｨｪｨｨｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨ 09ｨｰｨ 05ｨｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪｨｮ06 ｨｺｨｮ05ｨｹｨｰ06 ｨｪ020809ｨ ｨｪｨ 10 ｨｬｨｬ ｨｨ 04ｨ ｨｺｨ ｨｪ ﾂｨｨ09ｨ 05ｨｨ09ｨｹ 08ｨ 0903ｨｨ0802ｨｪｨｨ07ｨｬｨｨ, 04ｨ ｨｺ06ｨｰ060804ｨｬｨｨ ｨｪｨ ｨ ｨ 05ｨｨ ｨ ｨｰ080600ｨｨ ｨｨｨｰ0205ｨｹｨｪ ｨｪ020809ｨ 09 ｨｰｨｨ07ｨｨ ﾂｨｪ04ｨｬ ｨ 09ｨｰ ｨｨ060406ｨｬ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｪｨ ｨｬ ｨｨ 0102ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨｨｪｨｪ06ｨｬ ｨｬ ﾂｨ 09ｨｰｨｨ ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｺ06ｨｪ ｨｪｨｪ ｨｨｨｪｨｪ ｨｬ060400ｨ. 0608ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ ｨｺｨｰｨｨ09ｨｪｨ ｨｨ ﾂ02ｨｪｨｨｨｨ 0102ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨｨ08ｨｮ06ｨｴｨｨ01 04ｨ ｨ ｨ ｨｪｨｨｨｦ 09 05ｨｺ ｨｨｨｬ02ｨｪｨｰ02. 06ｨ ｨｺ, S.C. Barnett ｨｨ 0906ｨ 09ｨｰ [1] 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ , ｨｨ040605ｨｨ080609ｨ ｨｪｨｪ0402 ｨｨ ﾂ ｨｺｨ, ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｺ0906ｨｪ0609 ｨｮ ｨｺ ｨ 08ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 0102ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ 07ｨｮｨｰ02ｨｬ ｨｦ09ｨｰ09ｨｨ ｨｪｨｰ0002ｨｪ060909ｨｺ ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 ｨｪｨ 0006ｨｪ ｨｪｨｨ07 05ｨｰｨｨ01ｨｨ07 ｨ 0806ｨｬｨｨ01ｨ. 01ｨ ｨ ｨｪｨ ｨｨ ﾂｨｪ06ｨｦ ｨｬ ｨｨ 0102ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ T. Imaizumi ｨｨ 0906ｨ 09ｨｰ [14] ｨｮ09ｨｰｨ ｨｪ0609ｨｨ05ｨｨ, ﾂｨｰ ｨ 09ｨｨ09ｨｨｨｬｨ 07 ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨ07 ｨ ｨｺ0906ｨｪ ｨｪｨｪ ｨｬ060400ｨ 06ｨ ｨｮ ｨｨ09ｨ 02ｨｰ ｨｮ05ｨｮ ﾂ0302ｨｪｨｨ ｨｺｨ 04ｨ ｨｰ020502ｨｦ ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｨｨｬ0609ｨｰｨｨ ｨｺｨｰ08ｨｨ ﾂ0209ｨｺ ｨ ｨｮ030102ｨｪｨｨ Radtke ｨｨ 0906ｨ 09ｨｰ [27] 0609ｨｮｨｴ0209ｨｰ ｨｨ ｨｺ0902ｨｪ060002ｨｪｨｪｨｮ06 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ ｨｺ06 06 ﾂｨｨｨｴ02ｨｪｨｪ ｨｮ ﾂｨ 09ｨｰ06ｨｺ 0102ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨ 0008ｨｨｨｺｨ ｨｪ09ｨｺｨｨ ｨｪ ｨ 0204ｨｹ07ｨｪ06ｨｺ. 0102ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｬ0601ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ , ｨｺ06ｨｰ ｨｮ ﾂｨ 05ｨｨ ｨｨ ｨｨｨｪｨｹｨｨ, 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｨ080609ｨ 05ｨｨ09ｨｹ ｨｺ06ｨｪ09ｨｰｨｨｨｰｨｮ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ 05ｨｺ ｨｨ02ｨｦ 0002ｨｪｨ H-ｨｰ08ｨ ｨｪ ｨ ﾁ ｨｬ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｮ 62,5% 03ｨｨ0906ｨｰｨｪ0401 ｨｪｨ ｨ ｨ 05ｨｨ ｨ 0302ｨｪｨｪｨｮ ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨ ｨ ｨｪｨｪ04ｨｬ ｨｨｨｬｨｬｨｮｨｪ0600ｨｨ09ｨｰ0601ｨｨｨｬｨｨ ﾂ0209ｨｺ ｨｨ ｨ ｨｪｨｨ ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨ07 ｨｪ020809ｨｪ ｨｺ06ｨｪ 0609ｨｮｨｴ0209ｨｰ ｨ 09ｨｹ ｨ 05ｨ ｨ ｨｪｨ ｨｺ ｨｹ ｨｬｨｨ080609ｨ ｨｪｨｨｨｨ ｨｬｨｨ0205ｨｨｨｪｨ ｨｪｨ. M. Sasaki ｨｨ 0906ｨ 09ｨｰ [34] ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨｨ080609ｨ 05ｨｨ , ｨｬ02 ﾂ02ｨｪｨｪ ｨｪ06ｨｬ ｨ 0205ｨｺｨ ｨｪ06ｨｦ 0005ｨｮ ｨｪ02ｨｨｨｨ, 09 06ｨ 05ｨ 09ｨｰｨｹ ｨｺｨｨ 04ｨ 01ｨｪ ｨｺｨ ｨｪｨ ｨｰｨｨｨｺｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｺ ｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨｨｨ 08ｨ ｨｪｨｨ07 ｨｬ02 ﾂ02ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 09 06ｨ 05ｨ 09ｨｰｨｨ ｨｪｨｨ07 ﾂ ｨｪ ｨｰ08ｨ 09ｨｬ04 ｨｮ09ｨｰｨ ｨｪ ｨｪ06, ﾂｨｰ ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ 09 ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｺ0906ｨｪ0609, ｨ 09ｨｰｨ 06ｨｴｨｨ01 09 ｨｨ ｨｬ06ｨｴｨｹ06 ﾂ ｨｪｨｮ ｨｺｨｨ ｨｰｨｨ ｨｪ0609ｨｰｨｹ 05ｨｰ06ｨｬｨｮ, J.G. Boyd ｨｨ 0906ｨ 09ｨｰ [4], ｨｨ ｨｹ04ｨｮ07 ｨｬ02 ﾂ02ｨｪｨｨ ｨｺｨｰ060806ｨｬ LacZ ｨｨ ｨｪｨｨ02 ｨｨ ｨ 05ｨ 09ｨｰｨｹ ｨｮ03ｨｨｨ ｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｺ , ﾂ ｨｪ ｨｬ ｨｨ080609ｨ ｨｪｨｨ ｨｪｨｨ07 ｨｪ02 ｨｪｨ ｨ ｨ 05ｨｨ ｨｮ ﾂｨ 09ｨｰｨｨ ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｺ0906ｨｪ ｨｨ 05ｨｰ06ｨｬ 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ06 ｨｮ ﾂｨ 09ｨｰｨｨ ｨ 08ｨ ｨ ｨｪｨｨｨｨ ｨｰ08ｨｮｨｺｨｰｨｮ08, 06ｨｺ08ｨｮ03ｨ 06ｨｴｨｨ01 ｨ ｨｺ0906ｨｪ04, ｨｺ06ｨｰ ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨｨ0806-

4 130306ｨｰ02ｨｪ02ｨｨｨ 05ｨｹｨｪｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 06ｨ ｨ ｨｺｨｨ09ｨ 06ｨｴｨｨ01 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨ0602ｨｨｨｰ0609 ｭ 7 09ｨ 05ｨｨ09ｨｹ 04ｨ 09 ﾂ02ｨｰ ｨ ｨｮｨｰ060002ｨｪｨｪ ｨｨ ｨｪ ｨｨｨｰ ｨｪｨｪ ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｮ 09ｨｪｨｮｨｰ0802ｨｪｨｪ02ｨｦ ｨｪ0609ｨｰｨｹ06 ｨｬ02 ﾂ02ｨｪ ｨｨ ｨｪ02ｨｦ ｨｬｨｬ0602ｨｨｨｰｨ ｨｬｨｨ 0609ｨｰｨ 09ｨ ｨｹ ｨ 0601ｨｪ ｨｰ08ｨ ｨｪ09ｨｰ0906 ｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ090609ｨ 05ｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ0402 ｨｺ06ｨｪｨｰｨ ｨｺｨｰ ｨ ｨｪｨｪ04ｨｬ T. Takami ｨｨ 0906ｨ 09ｨｰ [36], ｨｪｨ ｨｨｨ ｨｺｨｰｨｨ09ｨｪ04ｨｬｨｨ 09 06ｨｰｨｪ060302ｨｪｨｨｨｨ 0802ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｺ0906ｨｪ ｨｪ02 ｨｮ03ｨｨｨ ｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｰ0907 ｨｺ0502ｨｰｨｺｨｨ 0605ｨｨ ｨｪ ｨｨｨｨ, 0601ｨｪｨ ｨｺ06 ｨ ｨｰｨｰ08ｨ ｨｺ02ｨｨ07 ｨｪ02ｨｦ08ｨｨｨｰ ｨｪｨｮ ｨｪｨｨ ｨｮｨｴ0209ｨｰ ｨｰ0907 ｨ 05ｨ ｨ ｨｨ 09 05ｨｰｨｨｨｬ ｨｪ06 ｨｨ ｨｹ040609ｨ ｨｰｨｹ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ06 ｨｺ0502ｨｰ06ｨｺ 0605ｨｨ ｨｪ ｨｨｨｨ ﾂｨ 00 ｨｮ03ｨｨｨ ｨ, ｨ ｪ ｨｨ050203ｨ ｨｴｨｨ02 ｨｰｨｺｨ ｨｪｨｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ. 08ｨ ｨｺ 0601ｨｨｨｪ ｨｨ04 09ｨ 08ｨｨｨ ｨｪｨｰ0609 ｨｰ08ｨ ｨｺｨｰ0609ｨｺｨｨ ｨｮ ﾂ02ｨｪｨｪ ｨ ｨｺｨｰ0609, ｨｮ02ｨｰ 0708ｨｨ090209ｨｰｨｨ ｨｰ06 ﾂｨｺｨｮ ｨｪｨｨ07 Y. Li ｨｨ 0906ｨ 09ｨｰ [18], ｨｺ06ｨｰ ｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｪ0609ｨｰ060806ｨｪｨｪ02ｨｦ ｨｺｨｨ ｨｺ0608ｨｰｨｨｨｺ060907ｨｨｨｪｨ 05ｨｹｨｪ ｨｰ08ｨ ｨｺｨｰｨ ｨｺ ｨｮ09ｨｰｨ ｨｪ0609ｨｨ05ｨｨ, ﾂｨｰ06 ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨ07 ｨ ｨｺ0906ｨｪ ｨｮｨｴ0209ｨｰ ｨ 09ｨｹ 04ｨ 09 ﾂ02ｨｰ ｨｪ02ｨｦ ｨｬｨｬ0602ｨｨｨｰ ｨ ｨｪ , ｨｰ060001ｨ ｨｺｨ ｨｺ ｨ 09ｨｰ080602ｨｨｨｰ ｨ ｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ ｨｨ04 ｨｺｨｮ05ｨｹｨｰｨｮ ｨｬｨｨ080609ｨ 05ｨｨ 06ｨ ｨｴｨｨ02 ｨｪｨ 0708ｨ ｨｴｨｨ02 ｨｰ06ｨｪｨｪ0205ｨｨ ｨｮ ﾂｨｺ ｨｪ0208ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｪ02ｨｦ08ｨｨｨｰ ｨｰ06 04ｨ ｨｺ0506 ﾂ02ｨｪｨｨ ｨ 09ｨｮ02ｨｰ ｨｰｨ ｨｪｨｨ07ｨｬｨｨ ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺ06ｨｦ 08ｨ 04ｨｪ ｨｪ0609ｨｰｨｨ ｨｮ ｨｨ0701 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｪｨ ｨｺ06, J.G. Boyd ｨｨ 0906ｨ 09ｨｰ [3] ｨｮ09ｨｰｨ ｨｪ0609ｨｨ05ｨｨ, ﾂｨｰ , 09 06ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ ｨｺ0502ｨｰ06ｨｺ 0605ｨｨ ｨｪ ｨｨｨｨ, in vitro ｨｨ in vivo 05ｨｺ ｨｨ08ｨｮ06ｨｰ ｨ ｨｺｨｰｨｨｨｪ ｨ 06ｨｴｨｨｨｦ ｨ ｨｺ ｨｺｨ 05ｨｹ0706ｨｪｨｨｨｪ. 0308ｨｨ 05ｨｰ06ｨｬ ｨｨｨｪｨｰ08ｨ 0907ｨｨｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｪ02 ｨｪｨ ｨ ｨ 05ｨｨ ｨｰ08ｨ ｨｪ ｨｬｨ 02ｨｨｨｨ ｨｺｨ 05ｨｹ0706ｨｪｨｨｨｪ ｨｨｨｰ0205ｨｹｨｪ ｨｰｨ ｨｺ ｨｪｨ ｨ 02ｨｬ0402 ｨｪ02ｨｦ ｨｬｨｬ0602ｨｨｨｰ ｨ ｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ ｨ ｨｪ02ｨｪｨｨ02ｨｬ 0708ｨｨ09ｨｮｨｴｨｨ01 ｨｨｨｬ ｨｬ ｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ ｨｪ02ｨｦ080601ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ ｨｦ09ｨｰ ｨ ｨｪｨｨ04ｨｬ04 ｨ ｨｰｨｰ08ｨ ｨｺ02ｨｨｨｨ ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ0401 ｨｺ06ｨｪｨｮ ｨｰｨ 0708ｨｨ ｨｮ ﾂｨ 09ｨｰｨｨｨｨ ｨｨ ﾂｨｨｨｪ ｨｨｨｰ0205ｨｹｨｪ ｨｨ07ｨｪｨｨ ｨｪｨ ｨｪ0208ｨｨ08ｨｮ06ｨｴｨｨｨｦ ｨ ｨｺ0906ｨｪ ｨｪ02 ｨｨ04ｨｮ ﾂ02ｨｪ ｨ 00ｨ 06ｨｰ, ﾂｨｰ ｨｬｨｨ08ｨｮ06ｨｰ ｨｰｨｮｨ ｨｮ ｨ ｨｪ ｨｰ08ｨｮｨｺｨｰｨｮ0804 ｨｨ ｨ 05ｨ ｨ ｨｺ ｨｨｨｨ ｨ ｨｨｨｪ0609, 0902ｨｺ080202ｨｨｨｨ 00ｨ ｨｺｨｰ ｨｰｨ ｨｨ ｨ 0205ｨｺ0609 ｨｰｨｺｨ ｨｪ ｨｬｨ ｨｰ08ｨｨｨｺ09ｨ 0902ｨｺｨｰ0608ｨｨ04ｨｨ08ｨｮ06ｨｰ ｨｬ02ｨｴ02ｨｪｨｨ02 ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ0401 ｨｺ06ｨｪｨｮ090609, ﾂｨｰ06 06ｨ ﾂｨ 02ｨｰ 0908ｨ 09ｨｰｨ ｨｪｨｨ02 ｨｪ02ｨｦ08ｨｨｨｰ ｨｪｨｮ ｨｪｨｨ07 ｨｨ 01ｨｨ09ｨｰｨ 05ｨｹｨｪ0402 ｨｺ ｨｪ02ｨｬｨｮ ｨｮ ﾂｨ 09ｨｰｨｺｨｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ. 06ｨ ｨｺ, ｨｬ0502ｨｺ0607ｨｨｨｰｨ 06ｨｴｨｨ01 in vitro 05ｨｺ ｨｨ08ｨｮ06ｨｰ PSA-NCAM ｨｨ NCAM, in vivo ｨｨ in vitro 05ｨｺ ｨｨ08ｨｮ06ｨｰ L1, 05ｨ ｨｬｨｨｨｪｨｨｨｪ ｨｨ 0108ｨｮ00ｨｨ02 ｨ 0205ｨｺｨｨ 09ｨｪ02ｨｺ0502ｨｰ06 ﾂｨｪ ｨｬｨ ｨｰ08ｨｨｨｺ09ｨ, 06ｨ 05ｨ 01ｨ 06ｨｴｨｨ ｨ 0302ｨｪｨｪ04ｨｬ ｨｪ02ｨｦ08ｨｨｨｰ060002ｨｪｨｪ04ｨｬ 0102ｨｦ09ｨｰ09ｨｨ02ｨｬ [6, 11, 30, 31] ｨｺ0802ｨｰｨｨ08ｨｮ06ｨｰ NGF, BDNF, GDNF ｨｨ CNTF; 05ｨｺ ｨｨ08ｨｮ06ｨｰ ｨｺｨｨ090504ｨｦ ｨｨ 0609ｨｪ0609ｨｪ06ｨｦ FGF, TGFｦﾁ, IGF-I, IGF-II, PDGFｦﾁ, PDGFｦﾂ, ｨｪ02ｨｦ ｨｰｨｨ01 Y, ｨｪ02ｨｺ09ｨｨｨｪ 0005ｨｨｨ 05ｨｹｨｪ ｨｨ ｨｪｨｨ07, trkb, neurturin, ｨｰ GFRｦﾁ1 ｨｨ GFRｦﾁ2, ｨｪ06 ｨｪ02 05ｨｺ ｨｨ08ｨｮ06ｨｰ Ret, ｨ 0204 ｨｺ06ｨｰ ｨｨ00ｨｪｨ 05ｨｹｨｪｨ 07 ｨｰ08ｨ ｨｪ0901ｨｮｨｺ02ｨｨ07 ﾂ ｨｰｨｨ ｨｰ ｨｪ ｨｬ0603ｨｪｨ [4, 23, 32, 37]. 01ｨ ｨｺ06ｨｪ0202, in vivo 05ｨｺ ｨｨ08ｨｮ06ｨｰ 00ｨ 0502ｨｺｨｰｨｨｨｪ-3, ｨｺ06ｨｰ060804ｨｦ 0708ｨｨｨｪｨｨｨｬｨ 02ｨｰ ｨｮ ﾂｨ 09ｨｰｨｨ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨｨｨ 05ｨｰｨｨ01 ｨｺ0502ｨｰ06ｨｺ 09 ｨ ｨｺ0906ｨｪｨ ｨｬｨｨ 0902ｨｪ090608ｨｪ0401 ｨｪ02ｨｦ0806ｨｪ0609 [35]. 08ｨｪｨ 05ｨｨ ｨｨ ｨｪｨｪ ｨ ｨｪｨｪ ｨｨｨｰ0208ｨ ｨｰｨｮ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ, ﾂｨｰ ｨｺｨ ｨｺ ｨ 04ｨｦ ｨｬ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ04ｨｦ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ ｨｨ000208ｨｨ ﾂ0209ｨｺ ｨｰ010205ｨ 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨ ｨｪｨ 05ｨｨ04ｨ ｨｰ0608ｨ ｨｬ0600ｨｮｨｰ ｨ 04ｨｰｨｹ ｨｺｨｰｨｨ09ｨｪ06 ｨｨ ｨｹ040609ｨ ｨｪ ｨｪ02ｨｦ0806ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 0708ｨｨ ｨｰ08ｨ 09ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｬ ｨｪｨｨｨｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ , ｨ ｨｰｨ ｨｺ ｨｨ 0102ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨｨ08ｨｮ06ｨｴｨｨ ｨ ｨｪｨ ｨｺ06, ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ ｨｪｨ ｨｺ ｨｪｨｪ04ｨｦ ｨ 0605ｨｹ0306ｨｦ 05ｨｺ ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ04ｨｦ ｨｬｨ ｨｰ0208ｨｨｨ ｨ ｨｪｨｪ06ｨｬ ｨｪｨ 0708ｨ ｨｪｨｨｨｨ, ｨｬｨｪ0600ｨｨ ｨｬ02ｨｰ0601ｨｨ ﾂ0209ｨｺ ｨ 08ｨ ｨｺｨｰ0208ｨ ｨｪ020709ｨｪ04 ｨｨ ｨｰ0802ｨ ｨｮ06ｨｰ ｨｪｨｨ07 01ｨ 05ｨｹｨｪ02ｨｦ03ｨｨ01 ｨｨ ｨ ｨｪｨｨｨｦ ｨ ｨｨｨｬ06 ｨｮ0005ｨｮｨ 0502ｨｪｨｪ0602 ｨｨ04ｨｮ ﾂ02ｨｪｨｨ ｨｰ02ｨｪ02ｨｨｨ 05ｨｹｨｪ ｨｬ0603ｨｪ0609ｨｰ02ｨｦ , 09 ﾂｨ 09ｨｰｨｪ0609ｨｰｨｨ, ｨｨ ｨｨ000208ｨ ｨｰｨｨ09ｨｪ ｨｨ 01ｨｨ ｨｪ02ｨｨ ﾂｨｪ ｨｰ02ｨｪ02ｨｨｨ 05ｨ 09 ｨｮ ｨｨ01 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨ ｨｮ06ｨｰ ｨｪｨｨｨｰ0205ｨｹｨｪ06ｨｦ 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ ｨｬ02ｨｰ ｨｨ ｨｪ02ｨｨｨ 05ｨｹｨｪ ｨ ｨｪｨｨ ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨ01 09ｨ 08ｨｨｨ ｨｪｨｰ0609 ｨｺ0502ｨｰ06ｨｺ 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ ｨｮ06ｨｴｨｨｨｬ ｨｨ04ｨｮ ﾂ02ｨｪｨｨ02ｨｬ ｨｨ ｨｰ02ｨｪ02ｨｨｨ 05ｨｹｨｪ ｨｦ09ｨｰ09 ｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ ｨｹ040609ｨ ｨｪｨｨ07 09 ｨｺｨ ﾂ0209ｨｰ0902 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｬｨ ｨｰ0208ｨｨｨ 05ｨ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ 0708ｨｨ ｨｪｨｨｨｨ 0907ｨｨｨｪｨｪ ｨｬ060400ｨ ｨ ｨｨｨｬｨ ｨｰｨ ｨｺ ｨｺ ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪｨ 07 ｨ ｨ ｨ 02ｨｨ ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 08ｨ 0405ｨｨ ﾂｨｪ ｨｨ ｨｨｨｬ0208ｨｪ0401 ｨｪ0609ｨｨｨｰ020502ｨｦ ｨｺ0502ｨｰ06 ﾂｨｪ ｨｮ090702ｨｪ04ｨｨｨｦ ｨ ｨｰ06ｨｬ ｨｨ ﾂ0209ｨｺｨｨｨｬ ｨｨ04ｨｮ ﾂ02ｨｪｨｨ02ｨｬ 0802ｨ ｨｺ02ｨｨｨｨ 06ｨｺ08ｨｮ03ｨ 06ｨｴ ｨｴ0209ｨｰ09ｨ ｨｬ060400ｨ ｨｪｨ ｨｨｨｬ0705ｨ ｨｪｨｰｨ 02ｨｨ06 ｨｨ09ｨｺｨｮ0909ｨｰ0902ｨｪｨｪ0401 ｨｬｨ ｨｰ0208ｨｨｨ ｨｪｨｨ02 05ｨｰｨｨ ｨｨｨｬ0202ｨｰ 09ｨ 03ｨｪ ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺ ｨｪｨ ﾂ02ｨｪｨｨ ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ ｨｨ ｨｪ09ｨｰ090609ｨ ｨｪｨｨ07 08ｨ 02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｬ02ｨｰ ｨｨ ｨｹ040609ｨ ｨｪｨｨ ｨｪ02ｨｦ0806ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰ ｨｨｨｨ. 0507ｨｨ0906ｨｺ 05ｨｨｨｰ0208ｨ ｨｰｨｮ Barnett S.C., Alexander C.L., Iwashita Y. et al. 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6 130306ｨｰ02ｨｪ02ｨｨｨ 05ｨｹｨｪｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 06ｨ ｨ ｨｺｨｨ09ｨ 06ｨｴｨｨ01 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｨ0602ｨｨｨｰ0609 ｭ 9 spinal cord // J. Neurosci. ｪ ｪ V.25, N46. ｪ P.10700ｨC Sasaki M., Lankford K.L., Zemedkun M., Kocsis J.D. Identified olfactory ensheathing cells transplanted into the transected dorsal funiculus bridge the lesion and form myelin // J. Neurosci. ｪ ｪ V.24, N39. ｪ P.8485ｨC Storan M.J., Magnaldo T., Biol-N'Garagba M.C. et al. Expression and putative role of lactoseries carbohydrates present on NCAM in the rat primary olfactory pathway // J. Comp. Neurol. ｪ ｪ V.475, N3. ｪ P.289ｨC Takami T., Oudega M., Bates M.L. et al. Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord // J. Neurosci. ｪ ｪ V.22, N15. ｪ P.6670ｨC Woodhall E., West A.K., Chuah M.I. Cultered olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors // Brain Res. Mol. Brain Res. ｪ ｪ V.88. ｪ P.203ｨC Zhang X., Klueber K.M., Guo Z. et al. Adult human olfactory neural progenitors cultured in defined medium // Exp. Neurol. ｪ ｪ V.186, N2. ｪ P.112ｨC ｨｰ02ｨｪ0206ｨｦｨｪｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｰｨ 06 ﾂｨｨ01 ｨｪ ｨｨ ｨｨｨｰ0609 ｨｮ ｨｪ0609ｨｪ06ｨｬｨｮ 0506ｨｺｨｮ09ｨ ｨｪｨｪ ｨｺ ｨｪｨｪ ｨｨｨｪｨｪ ｨｬ0604ｨｺｨｮ ｨｨ ｨｦｨｪｨｨ01 ｨｪ ｨｨｨｬｨ ｨ 0506ｨｺ , 0502ｨｬ02ｨｪ0609ｨ , 08ｨｬ06ｨｪ09ｨｹｨｺｨｨｨｦ , ｨｪｨｮｨｰ06 09ｨｮ ﾂｨ 09ｨｪ06 ｨｮ ｨｪｨｪ ｨｰ06ｨ ﾂｨｪ ｨ 09ｨｰｨｨ090609ｨｰ ｨｰｨ 06 ﾂｨｨ01 ｨｪ ｨｨ ｨｨｨｰ0609 (020101) 0909ｨ ｨｮ ｨｪｨ 09ｨ 0305ｨｨ09ｨｮ ｨｹ ｨｺ0506ｨｰｨｨｨｪ 02ｨｹ ｨｰｨｨ07ｨｮ ｨｮ ｨｬｨｮ09ｨ ｨｪｨｪ ｨｰｨｮ ｨｪ02ｨｦ08ｨｨｨｰ ｨｪ090608ｨｪｨｨ01 ｨｪ02ｨｦ0806ｨｪ0609 ｨｪ ｨｰ ｨ ｨ ﾂ02ｨｪｨｪ ｨｰｨ ｨｪｨｪ07 09 ｨｰｨｺｨ ｨｪｨｨｨｪｨｮ ｨｪ ｨｨｨ ｨｮ05ｨｨｨｪｨｨ, 09 02ｨｺ ｨｨｨｬ02ｨｪｨｰ06 09ｨｨ09 ﾂ02ｨｪ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｰｨ ｨｺｨｰｨｨ09ｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ ｨｬ02ｨｰ ｨｪ ｨｪｨｪ ｨｪ0609ｨｰ ｨｨｨｪｨｪ ｨｬ0604ｨｺｨｮ ｨｨ ｨｦｨｪｨｨ01 ｨｪ Olfactory ensheathing cells potential effectiveness in spinal cord and peripheral nerves injury recovery treatment Tsymbalyuk V.I., Semenova V.M., Yaminsky Yu.Ya., Medvedev V.V. Modern conceptions of mammalian olfactory ensheathing cells (OEC) properties are presented. Taking into consideration an important role of this cell type in ensuring axons of receptor neurons ｯ into olfactory bulb tissue growth, some experimental data on OEC application for transplantation effectiveness and it ｯs perspectives for the aim to restore the spinal cord and peripheral nerves conduction are listed.