日本組織適合性学会誌第23巻2号

Size: px
Start display at page:

Download "日本組織適合性学会誌第23巻2号"

Transcription

1 Major Histocompatibility Complex 2016; 23 (2): HLA HLA 1)2) 1)2) 1)2) 1) 2) HLA T HLA X HLA HLA I HLA HLA KIR LILR NKG2/CD94 X 1 major histocompatibility complex: MHC human leukocyte antigen: HLA HLA HLA HLA 6 X HLA HLA I II HLA T HLA I T HLA I II HLA I X TEL: FAX: maenaka@pharm.hokudai.ac.jp 80

2 HLA MHC 2016; 23 (2) 2 HLA 1 HLA I HLA I 8-11 T I T HLA I HLA-A B C HLA I I I I I I HLA I 3 α1 α2 α3 1 β2 β2m 1 β2m 15 MHC HLA I α3 HLA I α1 α2 8 β 2 α 1B HLA I β2m HLA I free heavy chain:fhc fhc CD8 TCR/CD3 MHCI MHCII 1) 2 HLA II HLA II HLA-DR DQ DP B T HLA II 2 α α1 α2 β β1 β2 α β α1 β1 I 2 2) I I II α β 1A 2A II 図 1 HLA I A HLA I B HLA-A2 PDB ID: 2BCK β2m 81

3 MHC 2016; 23 (2) HLA 図 2 HLA II A HLA II B HLA-DR PDB ID: 3C5J α β 3 HLA HLA I II 1 2 HLA I II 3 I 8 11 II II B 3) II HLA I I transporter associated with antigen processing TAP I 図 3 HLA I II HLA-A2 HLA-DR HLA N 8 16 I 1 endoplasmic reticulum aminopeptidase 1 ERAP1 HLA I HLA-B27 ERAP1 4) HLA-B51 5) I I HLA-B27 N 2 P2 82

4 HLA MHC 2016; 23 (2) Arg 4 I HLA 4B HLA I X HLA-B*5701 T 6) HLA HLA II II II II class II-associated invariant-chain peptides CLIP II I II 5C II I II 3 HLA T 1 HLA I T T T cell receptor: TCR MHC I α1-α2 MHC I 図 4 HLA-B27 A HLA-B27/HIV KRWIILGLNK PDB ID: 2BSS HLA-B27 N P1-P10 B HLA-B27 P2 Arg C PDB ID 83

5 MHC 2016; 23 (2) HLA 図 5 HLA I II TCR A HLA I TCR PDB ID: 2VLR B HLA II TCR PDB ID: 1FYT C B IIβ TCR TCR HLA 1 2 TCR α β 5A I TCR HLA T I MHC I TCR Human immunodeficiency virus HIV 2 HLA II HLA II T HLA II T T HLA II 5B, C CLIP HLA-DR1 P1 C 7) TCR 4 HLA I HLA I HLA-A B C I I 1 1 HLA-E HLA-E I HLA-E 10 HLA-E*0101 HLA-E* % 1 Arg107Gly 2 8) HLA-E HLA I I 84

6 HLA MHC 2016; 23 (2) 1 I I HLA-E HLA I NKG2/CD94 HLA-F LILR? HLA-G LILRB1 LILRB2 LILRA3 KIR2DL4 CD1a 1b 1c T TCR CD1d NKT TCR CD1e MICA MICB NKG2D HLA-E NKG2/CD94 HLA-E I HLA-E I P2 P3 P6 P7 P9 2 HLA-G HLA-G HLA I HLA-G T HLA-G HLA-G I HLA-G1 G7 Cys42 HLA-G1 HLA-G5 HLA-G1 Cys42 N Asn86 9) in vivo 9,10) α2 HLA-G2 HLA-G6 HLA-G1 11) HLA-G 3 CD1 CD1 HLA I 6 CD1 CD1a, 1b, 1c, 1d 1e 5 3 I CD1a, 1b, 1c II CD1d III CD1e I, II CD1 CD1e CD1e CD1 I CD1 CD1 NKT γδ T IFN-γ IL-4 NKT I NKT II NKT I NKT TCR α Vα24Jα18 β Vβ11 invariant NKT inkt semi-invariant NKT 6 I NKT α- αgalcer αgalcer α αgalcer II NKT CD1d I NKT TCR αgalcer II NKT 1 7 CD1 85

7 MHC 2016; 23 (2) HLA 図 6 HLA I HLA II CD1d HLA I CD8 T HLA II CD4 T CD1d inkt HLA I HLA II TCR T CD1d inkt TCR inkt inkt inkt CD1 T 1 Mycobacterium tuberculosis I CD1 CD1a, 1b, 1c 7 inkt T inkt αgalcer α- α inkt NKT CD1a, 1b, 1c T CD1 MHC I α1, α2, α3 β2m α1-α2 MHC I 7 CD1 A F MHC A F 7 2 CD1b A F C T CD1 F F CD1b CD1c 86

8 HLA MHC 2016; 23 (2) 図 7 CD1d HLA-A2 A. CD1d PDB ID: 1ZT4 α1 α2 CD1d β2m αgalcer B. HLA-A2 PDB ID: 1DUZ α1 α2 HLA-A2 β2m C. A αgalcer D. CD1 C D C D TCR CD1 TCR CD1 TCR 8 I NKT TCR V α24-vβ11 CD1d II NKT TCR Vα1Jα26-Vβ16Jβ2.1 CD1d TCR HLA TCR TCR MHC MHC α1, α2 I NKT TCR TCR α β CD1d α1, α2 F CDR1α αgalcer CDR3α CD1d αgalcer CDR2β Tyr48, Tyr50 CD1d F II NKT TCR TCR α β CD1d α1, α2 A TCR CDR3α CD1d CDR3β αgalcer II NKT TCR II NKT TCR 5 HLA I 1 HLA I HLA I 87

9 MHC 2016; 23 (2) HLA の立体構造と免疫制御受容体の分子認識機構 図8 TCR-HLA 複合体と TCR-CD1d 複合体の比較 A. TCR と HLA-A2 複合体の結晶構造 PDB ID: 5D2L TCR HLA-A2 と β2m をリボンモデル ペプチドをスティックモデルで示した B. I 型 NKT 細胞の TCR と CD1d 複合体の結晶構造 PDB ID: 2PO6 TCR CD1d と β2m をリボンモデル αgalcer をスティックモデ ルで示した C. II 型 NKT 細胞の TCR と CD1d 複合体の結晶構造 PDB ID: 4EI5 TCR CD1d と β2m をリボンモデル スルファチドをスティッ クモデルで示した 細胞受容体がどのように認識し 免疫反応制御を行って 構造やクラス I に対する結合様式 特異性が異なってお いるのか HLA クラス I と受容体の複合体構造解析に り HLA クラス I が多種の受容体を用いて多面的に免 より明らかとなってきた HLA クラス I 受容体としては 疫制御を行っていることがうかがえる TCR CD8 に加え ペア型受容体に属する killer cell im- KIR LILR および CD94/NKG2 は いずれも相同性の munoglobulin-like receptor KIR および leukocyte immu- 高いリガンド結合部位を含む細胞外ドメインを持つが noglobulin-like receptor LILR CD94/NKG2 ファミリー 抑制性受容体と活性化受容体がそれぞれペアで存在する が報告されている 表 2 それぞれの受容体は自身の ペア型受容体である 88 12) 抑制性受容体は細胞内に immu-

10 HLA MHC 2016; 23 (2) 表 2 HLA I KIR2DL1 2 HLA-C KIR2DL2 1 HLA-C 2 HLA-C HLA-B KIR2DL3 1 HLA-C 2 HLA-C HLA-B KIR2DL4 HLA-G KIR2DL5 KIR3DL1 HLA-Bw4 HLA-A KIR3DL2 HLA-A3 A11 CpG ODN KIR3DL3 KIR2DS1 2 HLA-C KIR2DS2 HLA-A11 1 HLA-C KIR2DS3 2 HLA-C KIR2DS4 HLA-Cw4 A11 KIR2DS5 KIR3DS1 HLA-Bw4 HLA-A LILRB1 HLA-A B C E F UL18 CD94/NKG2A HLA-E CD94/NKG2C HLA-E CD94/NKG2E HLA-E NKG2D/NKG2D MICA MICB ULBP noreceptor tyrosine-based inhibitory motif ITIM Arg Lys immunoreceptor tyrosine-based activation motif ITAM HLA I I 2 2 KIR KIR KIR NK T Ig D0 D1 D2 2 KIR2D 3 KIR3D short S long L 9 HLA I KIR2DL KIR3DL ITIM KIR2DS KIR3DS Lys ITAM DNAX activating protein of 12 kda DAP12 KIR KIR2DL1 KIR2DS1 D1D2 5 KIR2D HLA KIR2D 2 β D1 D2 10A HLA 2 X KIR2D HLA-C HLA-C 2 77 Ser 80 Asn 1 HLA-C Cw1 Cw3 Cw7 Cw8 Cw12 Cw13 Cw14 KIR2DL2 2DL3 KIR2DS2 77 Asn 80 Lys 2 89

11 MHC 2016; 23 (2) HLA 図 9 KIR KIR2D D1-D2 D0-D2 ITIM KIR ITAM KIR KIR2DL4 ITIM ITAM FcRγ KIR2DL4 HLA-G A KIR2DL1 PDB ID: 2VLR B LILRB1 D1D2 PDB ID: 1G0X B LILRB2 D1D2 PDB ID: 2GW5 図 10 HLA I HLA-C Cw2 Cw4 Cw5 Cw6 Cw15 Cw17 Cw18 KIR2DL1 KIR2DS1 2 HLA-Cw3 1 /KIR2DL2 HLA-Cw4 2 /KIR2DL1 KIR HLA-C α1-α A HLA-C 80 KIR D1 44 KIR 44 Lys KIR2DL2 1 HLA-Cw3 Asn80 11B 44 Met KIR2DL1 HLA-Cw4 HLA-Cw4 Lys80 Lys80 KIR2DL1 Met44 Ser184 Glu187 11C KIR2DL1 Met44 Lys Lys HLA-Cw4 Lys80 HLA-Cw4 KIR KIR KIR2DL3 3 90

12 HLA MHC 2016; 23 (2) 図 11 KIR HLA I A KIR2DL1 HLA-Cw4 PDB ID: 1IM9 C B HLA-Cw3/KIR2DL2 1EFX HLA-Cw3 Asn80 KIR2DL2 Lys44 C HLA-Cw4/KIR2DL1 1IM9 HLA-Cw4 Lys80 KIR2DL1 Met44 Lys80 KIR2DL1 Ser184 Glu187 D KIR3DL1 HLA-B*5701 PDB ID: 3VH8 KIR2D KIR3DL1 HLA-Cw7 KYFDEHYEY RYRPGTVAL K d =6.9 μm NKADVILKY K d =115 μm MHCI / KIR2DS2 HLA-A11 KIR2D HLA-C KIR-HLA KIR3D HLA KIR3D HLA-A HLA-B 2 X KIR3DL1D1 HLA-B C KIR3D D0 11D KIR3DL2 HLA I CpG oligodeoxynucleotide ODN TLR9 NK KIR HLA I KIR 2 KIR KIR/HLA I KIR HLA I KIR/HLA I 13 15) KIR HLA KIR KIR MHC KIR HLA I 16,17) 3 LILR LILR 11 LILRB1-5 LILRA LILRA3 91

13 MHC 2016; 23 (2) LILRB1 B2 I I 2 KIR LILR KIR LILR 4 N D1D2 KIR2DL 2 10B, C KIR LILR HLA I LILRB1/HLA-A2 LILRB2/ HLA-G LILR B1 B2 D1-D2 β2m D1 α3 TCR KIR 12 LILR α3 β2m MHC I HLA TCR KIR KIR LILR 18) I T CD8 HLA I 18) LILRB1 B2 ITIM CD8 HLA I T in vivo T 19) LILRB1 B2 HLA I LILRB1 LILRB2 HLA-G HLA-G LILR LILRB1 HCMV HLA I UL18 LILRB1/UL18 HLA 図 12 LILRB1 HLA-A2 PDB ID: 1P7Q TCR KIR HLA I α3 β2m 2 LILRB1 LILRB1 HLA I UL18 α3 β2m α3 HLA I 1000 UL18 TCR KIR CD8 LILRB1 4 CD94/NKG2 HLA I HLA-E NK HLA-E HLA 9 5 Arg 8 HLA-E NK NKG2 CD94 NKG2 CD94 C NKG2 7 NKG2A, B, C, D, E, F, H NKG2 NK 13 CD94 / NKG2 NKG2C NKG2E NKG2H 92

14 HLA MHC 2016; 23 (2) 図 13 CD94/NKG2 CD94/NKG2 HLA-E NKG2C DAP12 NKG2A ITIM ITAM DAP12 NKG2A NKG2B ITIM NKG2D HLA-E NKG2A/CD94 NKG2C/CD94 HLA-E 6 NKG2 HLA-E NKG2A/CD94 HLA-G VMAPRTLFL HLA-E PDB IDs: 3CII and 3CDG 14 α1-α2 NKG2A CD94 HLA-E α1-α2 P5 Arg P8 Phe NKG2A/CD94 Arg Phe CD94 HLA-E NKG2A/CD94 CD94 NKG2A/CD94 HLA-E CD94 HLA-E 6 NKG2A/CD94 NKG2C/ CD94 NKG2 CD94 P5 Arg HLA-E 図 14 CD94/NKG2A HLA-G VMAPRTLFL HLA-E PDB ID: 3CDG HLA-E α1-α2 P5 Arg P8 Phe CD94/NKG2A 6 HLA TCR HLA-KIR HLA I HLA 1) Arosa FA, Santos SG, and Powis SJ: Open conformers: the hidden face of MHC-I molecules. Trends Immunol (28): , ) Dai S, Crawford F, Marrack P, et al.: The structure of HLA- DR52c: comparison to other HLA-DRB3 alleles. Proceedings of the National Academy of Sciences of the United States of America (105): , ) Jin H, Arase N, Hirayasu K, et al.: Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility. Proceedings of the National Academy of Sciences of the United States of America (111): ,

15 MHC 2016; 23 (2) 4) Keidel S, Chen L, Pointon J, et al.: ERAP1 and ankylosing spondylitis. Curr Opin Immunol (25): , ) Kirino Y, Bertsias G, Ishigatsubo Y, et al.: Genome-wide association analysis identifies new susceptibility loci for Behcet s disease and epistasis between HLA-B*51 and ERAP1. Nat Genet (45): , ) Chessman D, Kostenko L, Lethborg T, et al.: Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity. Immunity (28): , ) Gunther S, Schlundt A, Sticht J, et al.: Bidirectional binding of invariant chain peptides to an MHC class II molecule. Proceedings of the National Academy of Sciences of the United States of America (107): , ) Iwaszko M, and Bogunia-Kubik K: Clinical significance of the HLA-E and CD94/NKG2 interaction. Arch Immunol Ther Exp (Warsz) (59): , ) Shiroishi M, Kuroki K, Ose T, et al.: Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA- G dimer. The Journal of biological chemistry (281): , ) Kuroki K, Hirose K, Okabe Y, et al.: The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis. Human immunology (74): , ) Takahashi A, Kuroki K, Okabe Y, et al.: The immunosuppressive effect of domain-deleted dimer of HLA-G2 isoform in collageninduced arthritis mice. Human immunology ) Kuroki K, Furukawa A, and Maenaka K: Molecular recognition of paired receptors in the immune system. Frontiers in microbiol- HLA ogy (3): 429, ) Williams AP, Bateman AR, and Khakoo SI: Hanging in the balance. KIR and their role in disease. Mol Interv (5): , ) Parham P: MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol (5): , ) Carrington M, and Martin MP: The impact of variation at the KIR gene cluster on human disease. Curr Top Microbiol Immunol (298): , ) Hong HA, Loubser AS, de Assis Rosa D, et al.: Killer-cell immunoglobulin-like receptor genotyping and HLA killer-cell immunoglobulin-like receptor-ligand identification by real-time polymerase chain reaction. Tissue Antigens (78): , ) Bari R, Leung M, Turner VE, et al.: Molecular determinantbased typing of KIR alleles and KIR ligands. Clin Immunol (138): , ) Shiroishi M, Tsumoto K, Amano K, et al.: Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. Proceedings of the National Academy of Sciences of the United States of America (100): , ) Liang S, Zhang W, and Horuzsko A: Human ILT2 receptor associates with murine MHC class I molecules in vivo and impairs T cell function. European journal of immunology (36): ,

16 HLA MHC 2016; 23 (2) Structures and receptor recognition mechanism of HLA molecules Kimiko Kuroki 1)2), Shunsuke Kita 1)2), Katsumi Maenaka 1)2) 1) Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University. 2) Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University. Human Leukocyte Antigens (HLAs) are glycoproteins that exhibit unusually high genetic polymorphism as well as high polygenecity by forming a wide variety of gene families. HLAs generally display peptides derived from intracellular proteins to T cells, and furthermore, they interact with various immune cell surface receptors to control broad aspects of immune responses pleiotropically, resulting in the maintenance of homeostasis in our body. X-ray crystallography has remarkably contributed to understanding of precise mechanisms for these HLA interactions. In this issue, we describe molecular structures of HLAs and HLA-receptor complexes, showing how HLA molecules regulate immune responses, and further discuss about their relationship with diseases. Key Words: killer cell Ig-like receptors, leukocyte Ig-like receptors, X-ray crystallography, nonclassical HLA, CD94/NKG2 receptors

日本組織適合性学会誌第23巻2号

日本組織適合性学会誌第23巻2号 Major Histocompatibility Complex 2016; 23 (2): 115 122 HLA 1 1) 1) HLA MHC 1900 HLA HLA キーワード : HLA HLA HLA HLA 2 HLA HLA HLA 3 1 1 HLA HLA 図 1 2016 6 30 2016 8 2 105 0013 1 10 14 3 5 TEL: 03 5776 0048

More information

[ 別紙 1] 論文の内容の要旨 論文題目 NK 細胞受容体 NKG2 の発現解析および KIR (Killer cell Immunoglobulin-like receptor) の遺伝的多型解析より導き出せる 脱落膜 NK 細胞による母児免疫寛容機構の考察 指導教官 武谷雄二教授 東京大学大学

[ 別紙 1] 論文の内容の要旨 論文題目 NK 細胞受容体 NKG2 の発現解析および KIR (Killer cell Immunoglobulin-like receptor) の遺伝的多型解析より導き出せる 脱落膜 NK 細胞による母児免疫寛容機構の考察 指導教官 武谷雄二教授 東京大学大学 [ 別紙 1] 論文の内容の要旨 論文題目 NK 細胞受容体 NKG2 の発現解析および KIR (Killer cell Immunoglobulin-like receptor) の遺伝的多型解析より導き出せる 脱落膜 NK 細胞による母児免疫寛容機構の考察 指導教官 武谷雄二教授 東京大学大学院医学系研究科 平成 15 年 4 月入学 医学博士課程 生殖 発達 加齢医学専攻 久須美真紀 産科領域には

More information

第14〜15回 T細胞を介する免疫系.pptx

第14〜15回 T細胞を介する免疫系.pptx MBL CD8 CD4 8.1 8.2 5.20 8.3 8.4 8.5 8.6 8.7 8.8 8.9 8.10 8.18 B7 CD28 CD28 B7 CD28 8.13 2.22 NK Toll(TLR) LBP! LPS dsrna ssrna TLR1/2/6! TLR4 TLR5 TLR3 TLR7/9 CD14! JNK/p38! MyD88! IRAK! TRAF! NFκB! TNF-α

More information

免疫Ⅱ

免疫Ⅱ 100 100 100 1990 127 DNA DNA DNA DNA hybridization DNA RNA DNA DNA 128 12 µδγαε 129 300 1,200 500 50012 4 24,000 1,20024,000 2.910 7 10 8 rejection major histocompatibility complex MHC MHC MHC 130 MHC

More information

/‚“1/ŒxŒ{‚×›î’æ’¶

/‚“1/ŒxŒ{‚×›î’æ’¶ 60 1 pp.3-8 2010 1. H1N1 1) 2) 3) 4) ERATO 2009 H1N1 21 H1N1 HA PB2 2009 3 Pandemic H1N1 2009 WHO 6 11 21 2009 11 2010 4 21 H1N1 H1N1 2009 4 15 CDC 108-8639 4-6-1 TEL: 03-5449-5281 FAX: 03-5449-5408 E-mail:

More information

Major Histocompatibility Complex 2017; 24 (3): II MHC MHC Precision Medicine HLA personalized medicine precision medicine

Major Histocompatibility Complex 2017; 24 (3): II MHC MHC Precision Medicine HLA personalized medicine precision medicine 24 3 29 12 20 27 171 30 172 22 HLA-QC 175 30 HLA 182 183 30 HLA 190 30 192 30 HLA 194 29 HLA 196 29 HLA 198 J.J. van Rood 215 16 217 28 219 MHC 28 2 1 220 223 Major Histocompatibility Complex Official

More information

MHC23-3

MHC23-3 Major Histocompatibility Complex 2016; 23 (3): 168 184 1) 2) 3) 4) 5) 1) 6) 7) 8) 1) 2) 3) 4) HLA 5) 6) 7) 8) HLA 11 25 28 10 22 1 4 61 44 6 1 10 11 5 HLA 60 3 27 3 5 9 5 10 19 5 50 22.4 5.9 8.2% 78.7%

More information

α β αβ α β α β γ δ ε ζ α β α ζ β α β α α β

α β αβ α β α β γ δ ε ζ α β α ζ β α β α α β α β αβ α β αβ γδε ζ α β α ζ β αβ α α β A P-1 Lys N P2 Val P3 Lys P5 Asn P8 Lys P11 Thr C P-2 Pro P4 Gln P7 Leu P10 Ala P6 Thr P9 Leu B P1Tyr 1-1-N N P 4 P 6 P 7 P 9 1 1 C 1-N 1- T (TCR) C V HLA II 2 CD4

More information

Medical Journal of Aizawa Hospital Medical Journal of Aizawa Hospital Vol. 10 (2012) Key words ö γ µ Graves disease and Hashimoto s thyroiditis are autoimmune thyroid diseases. Graves disease causes

More information

PowerPoint プレゼンテーション

PowerPoint プレゼンテーション JSHI 教育講演 2018.9.23 認定制度試験問題を 中心とした HLA の解説 木村彰方東京医科歯科大学 難治疾患研究所 1 はじめに 日本組織適合性学会認定 HLA 検査技術者認定制度では 指導者および技術者の認定要件として筆記試験を課しています 昨年に引き続き 正答率が 40% 未満の問題 ( 難問 ) を中心に HLAの基礎について解説を行いますので 知識を確認してください. 2 問題

More information

平成24年7月x日

平成24年7月x日 荒瀬尚 ( あらせひさし ) 大阪大学免疫学フロンティア研究センター免疫化学研究室 / 微生物病研究所免疫化学分野 大阪大学の荒瀬尚教授らの研究グループは 自己免疫疾患で産生される自己抗体が 異常な分子複合体 ( 変性蛋白質と主要組織適合抗原との分子複合体 ) を認識することを発見し それが自己免疫疾患の発症に関 与していることを突き止めました < 研究背景 > 自己免疫疾患は 自己に対する抗体等が自己組織を誤って攻撃してしまうことで生じる疾患です

More information

A I (MHC-I; HLA-A, B, C H-2K, D, L ) II (MHC-II; HLA-DR, DQ, DP I-A, I-E ) CHO CHO m CHO CHO CHO B MHCI MHCII MHC-I MHC-II B (APC) T α β2 α α1, α2 α3 α β α β α1, α2, β1 β α1α2 ΙΙ α1β1 3 B B CD4 TCR MHC-II

More information

サイトメトリー20-1.indd

サイトメトリー20-1.indd The role of NK cell receptor-expressing cell on anti-leukemia/cancer immunological effect Junji Tanaka, M.D., Ph.D. Hematology and Oncology, Hokkaido University Graduate School of Medicine Abstract NK

More information

α κ λ α β β β β α

α κ λ α β β β β α α κ λ α β β β β α DR CDR2 CDR1 TCR V CDR1 CDR3 CDR3 74 73 71 70 CDR2 67 DR TCR V 66 DRB1*0101 (DR1Dw1) DRB1*0404 (DR4Dw14) RA DRB1*0405 (DR4Dw15) DRB1*0401 (DR4Dw4) DRB1*1001 (DR10) Asp 67 70 71 73 74

More information

Sport and the Media: The Close Relationship between Sport and Broadcasting SUDO, Haruo1) Abstract This report tries to demonstrate the relationship be

Sport and the Media: The Close Relationship between Sport and Broadcasting SUDO, Haruo1) Abstract This report tries to demonstrate the relationship be Sport and the Media: The Close Relationship between Sport and Broadcasting SUDO, Haruo1) Abstract This report tries to demonstrate the relationship between broadcasting and sport (major sport and professional

More information

1_alignment.ppt

1_alignment.ppt " " " " n " n n " n " n n n " n n n n " n LGPSSKQTGKGW-SRIWDN! + +! LN-ITKSAGKGAIMRLGDA! " n -------TGKG--------!! -------AGKG--------! " n w w w " n w w " " " 11 12 " n w w w " n w w A! M! O! A!

More information

1 Department of Legal Medicine, Toyama University School of Medicine 2 3 4 5 6 7 8 Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama VEGF Key words

More information

THE JAPANESE JOURNAL OF PERSONALITY 2007, Vol. 15 No. 2, 217–227

THE JAPANESE JOURNAL OF PERSONALITY 2007, Vol. 15 No. 2, 217–227 2007 15 2 217 227 2007 1 2 445 238 207 1 7 7 (2005) (2005) (2006a) 2006a (2004) (assumed-competence) 218 15 2 1 2005 2004 (2004) (2004) (2004) 16PF (2006) 4 Hayamizu, 2002 2006a (2006a) 1 Hayamizu, Kino,

More information

DynalTransplantDiagnostic.indd

DynalTransplantDiagnostic.indd 2011 1 SeCore HLA SBT 1 2 AllSet + Gold SSP HLA 7 3 SSP UniTray HLA 11 4 27 5 32 ii 1 SeCore HLA SBT SeCore 2 SeCore HLA SBT SeCore 3 SeCore 4 HLA-I 5 HLA-II 5 utype 5 GSSP 6 1 SeCore HLA SBT Sequencing

More information

く 細胞傷害活性の無い CD4 + ヘルパー T 細胞が必須と判明した 吉田らは 1988 年 C57BL/6 マウスが腹腔内に移植した BALB/c マウス由来の Meth A 腫瘍細胞 (CTL 耐性細胞株 ) を拒絶すること 1991 年 同種異系移植によって誘導されるマクロファージ (AIM

く 細胞傷害活性の無い CD4 + ヘルパー T 細胞が必須と判明した 吉田らは 1988 年 C57BL/6 マウスが腹腔内に移植した BALB/c マウス由来の Meth A 腫瘍細胞 (CTL 耐性細胞株 ) を拒絶すること 1991 年 同種異系移植によって誘導されるマクロファージ (AIM ( 様式甲 5) 氏 名 山名秀典 ( ふりがな ) ( やまなひでのり ) 学 位 の 種 類 博士 ( 医学 ) 学位授与番号 甲 第 号 学位審査年月日 平成 26 年 7 月 30 日 学位授与の要件 学位規則第 4 条第 1 項該当 Down-regulated expression of 学位論文題名 monocyte/macrophage major histocompatibility

More information

CAR-T実施

CAR-T実施 Building a Clinical CAR-T Program - Jichi Medical University Experience l l l Anti-CD3/28 mabs & IL-2: 29% Anti-CD3/28 beads: 66% Retroviral: 41% Lentiviral: 54% T-Flasks: 22% Static Culture Bags: 35%

More information

BE0005 TS-1/ InVivoMab anti-human LFA-1α (CD11a) mouse IgG , ,000 BE0005 TS-1/ InVivoMab anti-human LFA-1α (CD11a) mous

BE0005 TS-1/ InVivoMab anti-human LFA-1α (CD11a) mouse IgG , ,000 BE0005 TS-1/ InVivoMab anti-human LFA-1α (CD11a) mous Bio X Cell 社価格表 (2018 年 4 月 ) < 株式会社シン コーポレーション > Bio X Cell 社価格表 (2018 年 4 月 ) ご注文ごとに別途取扱手数料 (2( 万円 税別 ) を申し受けます 大学向け価格でのご購入には アカデミックプライス適用申込書のご提出が必須となります 品番クローン品名イソタイプ 容量 (mg) 大学向希望小売価格 ( 円 ) 税別 希望小売価格

More information

VENTANA PD-L1 SP142 Rabbit Monoclonal Antibody OptiView PD-L1 SP142

VENTANA PD-L1 SP142 Rabbit Monoclonal Antibody OptiView PD-L1 SP142 VENTANA PD-L1 SP142 Rabbit Monoclonal Antibody OptiView PD-L1 SP142 2 OptiView PD-L1 SP142 OptiView PD-L1 SP142 OptiView PD-L1 SP142 PD-L1 OptiView PD-L1 SP142 PD-L1 OptiView PD-L1 SP142 PD-L1 OptiView

More information

) 5 Lawton QOL 4 4 QOL Lawton 4) Philadelphia Geriatric Center Affect Rating ScaleARS ARS QOL 5) HDS R

) 5 Lawton QOL 4 4 QOL Lawton 4) Philadelphia Geriatric Center Affect Rating ScaleARS ARS QOL 5) HDS R Vol. 12 No. 2 2002 389 397 Λ1 Λ2 16 10 30 1 2 Lawton Philadelphia Geriatric Center Affect Rating ScaleARS Lawton ARS + ARS 6 2 ARS 2 12:00 15:0017:00 11:30 16:00 1 2 ARS 1 2 ARS QOL QOL QOL 1) QOL QOL

More information

…GŒÆ›u››‘KŒâ‚è_cs1.indd

…GŒÆ›u››‘KŒâ‚è_cs1.indd 1 1-1 4 1-2 a. b. c. d. e. 1-3 A. 4 B. 3 1-4 a. b. c. d. e. 1-5 1-6 4 1-7 a. b. c. d. e. 1-8 a. b. c. d. e. 1-9 1-10 A. 2 B. C. 1-11 a. / 2 b. / c. / d. / e. / 1-12 a. T b. c. M d. e. 1-13 1-14 1-15 16

More information

History I COE

History I COE 2008 108-8641 5-9-1 TEL 03-5791-6334FAX 03-5791-6335 e-mailgakufu@lisci.kitasato-u.ac.jp 228-8555 1-15-1 TEL 042-778-9760FAX 042-778-9761 e-mailnyushi@kitasato-u.ac.jp URL http://www.kitasato-u.ac.jp/lisci/index.html

More information

第124回日本医学会シンポジウム

第124回日本医学会シンポジウム III γ γ γ α γ Molecular Mechanism of Insulin Resistance by Adipocytes TAKASHI KADOWAKI Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo Key words γ 110 124 TNFα FFA 1,2

More information

平成14年度 本態性多種化学物質過敏状態の調査研究 研究報告書

平成14年度 本態性多種化学物質過敏状態の調査研究 研究報告書 226 227 µ 228 Ω 229 230 0 ppb 2000ppb DG subthreshold (µa) 91 ± 59 86 ± 68 max stim. (µa) 755 ± 287 n=37 678 ± 300 max PS (mv) 8.7 ± 3.9 7.7 ± 4.3 n=61 CA1 subthreshold (µa) 36 ± 26 32 ± 13 max stim. (µa)

More information

25 6 7 X (crystallizing ligand) Fv Fv 3.5 Co-crystallization of membrane proteins with antibody fragments may emerge as a general tool to facilitate crystal growth and improve crystal quality. The bound

More information

Dill,, pp. - - EU i - - i - - - COE - COE COE COE Good Practice GP GP GP GP JABEE INQAAHE PDCA Plan-Do-Check-Action - FD FD - - Rice,, p. niche - i - -Jones,, pp. - MCAT - - - - - - - - - - - - - -

More information

udc-2.dvi

udc-2.dvi 13 0.5 2 0.5 2 1 15 2001 16 2009 12 18 14 No.39, 2010 8 2009b 2009a Web Web Q&A 2006 2007a20082009 2007b200720082009 20072008 2009 2009 15 1 2 2 2.1 18 21 1 4 2 3 1(a) 1(b) 1(c) 1(d) 1) 18 16 17 21 10

More information

16_.....E...._.I.v2006

16_.....E...._.I.v2006 55 1 18 Bull. Nara Univ. Educ., Vol. 55, No.1 (Cult. & Soc.), 2006 165 2002 * 18 Collaboration Between a School Athletic Club and a Community Sports Club A Case Study of SOLESTRELLA NARA 2002 Rie TAKAMURA

More information

Perspective-Taking Perspective-Taking.... Vol. No.

Perspective-Taking Perspective-Taking.... Vol. No. Nurses Thinking Process in Understanding Patients Unconscious Denial Tomoko Hayashi Key Words putting oneself in the patient s place, perspective-taking, misunderstand patient s perspective, modifying

More information

著者 : 黒木喜美子 1, 三尾和弘 2, 高橋愛実 1, 松原永季 1, 笠井宣征 1, 間中幸絵 2, 吉川雅英 3, 浜田大三 4, 佐藤主税 5 1, 前仲勝実 ( 1 北海道大学大学院薬学研究院, 2 産総研 - 東大先端オペランド計測技術オープンイノベーションラボラトリ, 3 東京大学大

著者 : 黒木喜美子 1, 三尾和弘 2, 高橋愛実 1, 松原永季 1, 笠井宣征 1, 間中幸絵 2, 吉川雅英 3, 浜田大三 4, 佐藤主税 5 1, 前仲勝実 ( 1 北海道大学大学院薬学研究院, 2 産総研 - 東大先端オペランド計測技術オープンイノベーションラボラトリ, 3 東京大学大 PRESS RELEASE (2017/4/4) 北海道大学総務企画部広報課 060-0808 札幌市北区北 8 条西 5 丁目 TEL 011-706-2610 FAX 011-706-2092 E-mail: kouhou@jimu.hokudai.ac.jp URL: http://www.hokudai.ac.jp 異なるクラスの MHC 分子の特徴的構造をあわせ持つ免疫抑制タンパク質 HLA-G

More information

第26回日本サルコイドーシス/肉芽腫性疾患学会総会議事報告

第26回日本サルコイドーシス/肉芽腫性疾患学会総会議事報告 26 2005 2005 2006 2006 2005 2005 Prof. Gianfranco Rizzato D. Geraint James W. Jones Williams Om P. Sharma 28 28 26 26 10WASOG 2007WASOG-DLD Diffuse Lung Disease Conference2007 10 WASOG2007 109 2007, 27

More information

untitled

untitled Quantitative Risk Assessment on the Public Health Impact of Pathogenic Vibrio parahaemolyticus in Raw Oyster 1 15 5 23 48 2 21 1 16 1 16 1 11 3 1 3 4 23 1 2 16 12 16 5 6 Hazard IdentificationExposure

More information

udc-4.dvi

udc-4.dvi 43 (2) 20 21 14 19 20 21 1 11 14 2009 12 10 44 No.39, 2010 2005 2008 19 2009 20 2 2009 21 20 21 2 20 21 20 8 31 21 11 12 20 6 21 5 1 2 3 20 21 8 1 2 2 1 21 3.1 3.1.1 1 20 20 8 31 1. (5) 2. 3. AO 4. AO

More information

研究成果報告書

研究成果報告書 Functional analysis on EphB and ephrin-b expressing in gastric mucosaand their expression behavior in gastric ulcer and cancer EphBephrin-B EphBephrin-Bephrin-BEphB Gastric UnitEphB2 EphBephrin-BEphB/ephrin-B

More information

第4回企画展 わたしたちの脳

第4回企画展 わたしたちの脳 "The Wisdom of the Body" The Structure of Brain Peripheral Nervous System Localization of Brain Function Homeostasis The Brain Difference between Humans and Other Mammals The history of brain research

More information

研究成果報告書

研究成果報告書 X-SCID T NK Omenn T T 2007 2008 0menn T 1. 研究開始当初の背景 T T T T reversion T T 2. 研究の目的 RAG1/RAG2 Artemis T TCR T TCR 3. 研究の方法 RAG1/RAG2 μ μ μ μ μ μμ μμ μ 解析ダイアグラム 3-D display による TCR 多様性の評価 4. 研究成果 TCR T

More information

Microsoft Word - 要旨集3.doc

Microsoft Word - 要旨集3.doc RIKEN Symposium MHC Dynamics and functions of the MHC genes of animals from fish to human- Friday, Apl. 15, 2005 10:00-17:10 Okochi Hall, RIKEN (The Institute of Physical and Chemical Research) Contact:

More information

2 251 Barrera, 1986; Barrera, e.g., Gottlieb, 1985 Wethington & Kessler 1986 r Cohen & Wills,

2 251 Barrera, 1986; Barrera, e.g., Gottlieb, 1985 Wethington & Kessler 1986 r Cohen & Wills, 2014 25 1 1 11 1 3,085 100 1 1988 e.g., 2000 3 e.g., 2005; 1999 100 1960 100 2012 2 6 23 1 98.2 1999 1999 3 65.3 1999 1996 1 21 e.g., 1999 3 1 2 251 Barrera, 1986; 1993 1 2 2001 3 2001 Barrera, 1981 1993

More information

137 Author s E-mail Address: torii@shoin.ac.jp Relationship between appearance modifying behavior and narcissistic tendency in Japanese males TORII Sakura Faculty of Human Sciences, Kobe Shoin Women s

More information

<31302D8EC091488CA48B862D8E52936389698E7190E690B691BC2D3296BC976C2E706466>

<31302D8EC091488CA48B862D8E52936389698E7190E690B691BC2D3296BC976C2E706466> 77 1 1 1 Comparative analysis of training regimens between top European and Japanese women s youth handball teams with a focus on shooting Eiko Yamada 1 Hiroshi Aida 1 and Akira Nakagawa 1 Abstract In

More information

56 56 The Development of Preschool Children s Views About Conflict Resolution With Peers : Diversity of changes from five-year-olds to six-year-olds Y

56 56 The Development of Preschool Children s Views About Conflict Resolution With Peers : Diversity of changes from five-year-olds to six-year-olds Y 56 56 The Development of Preschool Children s Views About Conflict Resolution With Peers : Diversity of changes from five-year-olds to six-year-olds Yukari KUBO 311615 1 1 1 97 43-2 2005 Rubin, Bukowski,

More information

社会技術論文集

社会技術論文集 STS Studies on Kanemi-Yusho Case with Special Interests on the Accident Investigation 1 1 M.Sc. (E-mail:tnakaji@plum.ocn.ne.jp) 1968 PCB 1. 2003 15 5 23 9;37 1900 2003 33 2 2 BSE 3 8; 14 2001 9 BSE 1 BSE

More information

303 Human Factors in Nuclear Power Plant with Focus on Application of Man-machine Interface and Advanced Data Processing Technologies to Nuclear Power Industry Abstract We discuss issues involved in a

More information

20 Method for Recognizing Expression Considering Fuzzy Based on Optical Flow

20 Method for Recognizing Expression Considering Fuzzy Based on Optical Flow 20 Method for Recognizing Expression Considering Fuzzy Based on Optical Flow 1115084 2009 3 5 3.,,,.., HCI(Human Computer Interaction),.,,.,,.,.,,..,. i Abstract Method for Recognizing Expression Considering

More information

MM0506-Ariyoshi.ind

MM0506-Ariyoshi.ind 51 2005133 Six years of experiences at the U.K. MRC Laboratories, The Gambia, in West Africa Koya ARIYOSHI 130 1965 1992 Jonathan Weber Medical Research Council MRC Laboratories, The Gambia HIV Virologist/Immunologist

More information

process of understanding everyday language is similar, finally as far as word production is concerned, individual variations seem to be greater at an

process of understanding everyday language is similar, finally as far as word production is concerned, individual variations seem to be greater at an Understanding of Language in Early Development ( ) Research by Visiting Home (3) Center of developmenta1 education and research Center of developmenta1 education and research Center of developmenta1 education

More information

WATOC2005 Best Poster Diamond Certificate α -(BEDT-TTF) 2 IBr 2 H.turkmenica X H C H O Brønsted Al K Electronic structure of CeNiGe 2 x Si x studied by Ce 4d-4f resonant and angleresolved photoemission

More information

untitled

untitled ORYZA POLYAMINE ORYZA POLYAMINE -P -PC -LC 1. Ver.1.0 MM ver. 1.0MM 1) Roseeuw D.I. et al., Epidermal keratinocytes actively maintain their intracellular polyamine levels. Cell Tissue Kinet. 16, 493-504

More information

研究成果報告書(基金分)

研究成果報告書(基金分) (1) 種類 程度 肥満細胞数の測定と組織でのサ RT-PCR FACS () (1) NMU-/- IgE NMU IgE -/-NMU -/-B IgE NMU -/-B6 IgE NMU NMU CTLMC BMMC IgE NMU CTLMC 13 1. Hayakawa J, Mizukawa Y, Kurata M, Shiohara T: A syringotropic variant

More information

622 3) 4 6) ) 8) , ,921 40, ) ) 10 11) ) ) ,434 43, ,18

622 3) 4 6) ) 8) , ,921 40, ) ) 10 11) ) ) ,434 43, ,18 Vol. 15 No. 2 2006 621 626 Λ1 1959 1995 2004 1959 1995 2004 7 1 2) 1 6 3) 11 Λ1 701-0193 288 E-Mail: takao@mw.kawasaki-m.ac.jp 621 622 3) 4 6) 8 15 7) 8) 2 2 1 1959 34 4,697 401 38,921 40,838 500 9) 9

More information

KII, Masanobu Vol.7 No Spring

KII, Masanobu Vol.7 No Spring KII, Masanobu 1 2 3 4 5 2 2.1 1945 60196075 19759019904 002 Vol.7 No.1 2004 Spring 1194560 1 1946 2 195328 3 4 1958 1960 2196075 5 6 7 8 1946 2 1972 1/23/4 1974 1968481973 1969 3197590 9 1980 1987 41990

More information

VOL. 37 NO. 3 Key words: Drug allergy, LMIT, Penams, Cephems, Cross-reactivity

VOL. 37 NO. 3 Key words: Drug allergy, LMIT, Penams, Cephems, Cross-reactivity VOL. 37 NO. 3 Key words: Drug allergy, LMIT, Penams, Cephems, Cross-reactivity CHEMOTHERAPY MAR. 1989 Mble 1. Allcrgy in parients nduced by penams VOL. 37 NO. 3 Table 2. Allergy in patients induced by

More information

研修コーナー

研修コーナー l l l l l l l l l l l α α β l µ l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l

More information

日本消化器外科学会雑誌第29巻第9号

日本消化器外科学会雑誌第29巻第9号 Table 1 Oligonucleotide primers used for RT-PCR and internal probes used for Southern blot hybridization Cytokine Primer Sequence (5'-3') 5' 3' Internal probe s' 3' Internal probe 5' 3' Internal probe

More information

16 MHC 2018; 25 (1) 参加費 1 2, , ,000 会議等 :00 13: :00 13: :20 会場地図 TEL JR 350 m 57

16 MHC 2018; 25 (1) 参加費 1 2, , ,000 会議等 :00 13: :00 13: :20 会場地図 TEL JR 350 m 57 Major Histocompatibility Complex 2018; 25 (1): 56 82 抄録集 16 2018 3 3 7 2 4 43 TEL 06 6962 7001 594 1101 840 TEL 0725 56 1220 56 16 MHC 2018; 25 (1) 参加費 1 2,000 2 1,000 3 3,000 会議等 1 3 3 13:00 13:10 2 3

More information

( 報告様式 4) 16cm h0001 平成 29 年 5 月 30 日 平成 28 年度委託研究開発成果報告書 I. 基本情報 事業名 : ( 日本語 ) 次世代がん医療創生研究事業 ( 英語 ) Project for Cancer Research and Therapeutic

( 報告様式 4) 16cm h0001 平成 29 年 5 月 30 日 平成 28 年度委託研究開発成果報告書 I. 基本情報 事業名 : ( 日本語 ) 次世代がん医療創生研究事業 ( 英語 ) Project for Cancer Research and Therapeutic ( 報告様式 4) 16cm0106111h0001 平成 29 年 5 月 30 日 平成 28 年度委託研究開発成果報告書 I. 基本情報 事業名 : ( 日本語 ) 次世代がん医療創生研究事業 ( 英語 ) Project for Cancer Research and Therapeutic Evolution 研究 研究開発担当者 ( 日本語 ) 国立大学法人神戸大学大学院医学研究科特命教授高井義美所属役職氏名

More information

00.\...ec5

00.\...ec5 Yamagata Journal of Health Science, Vol. 6, 23 Kyoko SUGAWARA, Junko GOTO, Mutuko WATARAI Asako HIRATUKA, Reiko ICHIKAWA Recently in Japan, there has been a gradual decrease in the practice of community

More information

MHC 2013; 20 (1) 11 参加費 1 2, , ,000 会議等 :50 14: :30 13: :00 会場地図 参天製薬株式会社本社案内図 TEL 新大阪駅より

MHC 2013; 20 (1) 11 参加費 1 2, , ,000 会議等 :50 14: :30 13: :00 会場地図 参天製薬株式会社本社案内図 TEL 新大阪駅より Major Histocompatibility Complex 2013; 20 (1): 63 89 抄録集 11 2013 2 2 3 9 19 TEL: 06 6321 7000 630 0293 1248 1 TEL: 0743 77 0880 E-mail: tubaki@nara.med.kindai.ac.jp 63 MHC 2013; 20 (1) 11 参加費 1 2,000 2

More information

Fig.l Music score for ensemble Fig.Z Definition of each indicator Table I Correlation coefficient between hitting lag variation /,(n) and hitting cycl

Fig.l Music score for ensemble Fig.Z Definition of each indicator Table I Correlation coefficient between hitting lag variation /,(n) and hitting cycl It is difficult problem to make a human like ensemble system, In this research, we analyzed the rhythm interaction between performers by measure the hutting time and hitting cycle of keyboard performance.

More information

理科教育学研究

理科教育学研究 Vol.No. 資料論文 doi:. /sjst.sp 昆虫の体のつくり の学習前後における児童の認識状態の評価 自由記述法と描画法を併用して A B AB A A B B [ キーワード ] 1. はじめに 1.1 問題の所在 Cinici Shepardson Shepardson Cinici 1.2 評価実施の目的 2. 評価の実施の方法 2.1 評価ツールの選定, 及び評価シートの作成 B

More information

untitled

untitled 2010 58 1 39 59 c 2010 20 2009 11 30 2010 6 24 6 25 1 1953 12 2008 III 1. 5, 1961, 1970, 1975, 1982, 1992 12 2008 2008 226 0015 32 40 58 1 2010 III 2., 2009 3 #3.xx #3.1 #3.2 1 1953 2 1958 12 2008 1 2

More information

2009年度 東京薬科大学 薬学部 授業計画

2009年度 東京薬科大学 薬学部 授業計画 2009 2 234 Tokyo University of Pharmacy and Life Sciences since 880 Tokyo University of Pharmacy and Life Sciences Department of Clinical Pharmacy Men's Division Department of Clinical Applied Pharmacy

More information

Japanese Journal of Applied Psychology

Japanese Journal of Applied Psychology Japanese Journal of Applied Psychology 2014, Vol. 40, No. 2, 71 81 1) * Donations and Money-Beliefs, Empathy, and Normative Attitudes About Helping after Great East Japan Earthquake Nobuko WATANABE* Relationships

More information

本文/AY380J

本文/AY380J MHC-II II MHC-II MHC- II CD T T TCR T T MHC-II MHC-II T MHC-II MHC-II MHC-II MHC-II Ii Ii-MHC-II MHC-II antigen processing compartment MIIC Regulation of cell surface expression of MHC-II in dendritic

More information

ŁRŁ¸•ñŁŁŁ‘

ŁRŁ¸•ñŁŁŁ‘ 16 11 5 25mg 14 11 18 1 25mg 1 150,000 934 1 2 : 1-235-tumor necrosis factor receptor (human) fusion protein with 236-467-immunoglobulin G1 (human γ1-chain Fc fragment), dimmer : : 1 235 236 467 G 1 γ1

More information

Juntendo Medical Journal

Juntendo Medical Journal * Department of Health Science Health Sociology Section, Juntendo University School of Health and Sports Science, Chiba, Japan (WHO: Ottawa Charter for Health promotion, 1986.) (WHO: Bangkok Charter

More information

06_学術_関節単純X線画像における_1c_梅木様.indd

06_学術_関節単純X線画像における_1c_梅木様.indd Arts and Sciences X The formulation of femoral heard measurement corrected enlargement ratio using hip joints X-ray Imaging 1 2 1 1 1 2 Key words: Bipolar Hip Arthroplasty (BHA) Preoperative planning Enlargement

More information

IR0036_62-3.indb

IR0036_62-3.indb 62 3 2016 253 272 1921 25 : 27 8 19 : 28 6 3 1921 25 1921 25 1952 27 1954 291960 35 1921 25 Ⅰ 0 5 1 5 10 14 21 25 34 36 59 61 6 8 9 11 12 16 1921 25 4 8 1 5 254 62 3 2016 1 1938.8 1926 30 1938.6.23 1939.9

More information

untitled

untitled Vol. 19 No. 1 2009 13 23 Λ1 Λ2 2 1) 10 1 Infertility 1785 1978 1980 1983 IVF-ET 2) 1 1 1 6 65% 1 80% Λ1 Λ2 701-0193 288 E-Mail: hiro210691@yahoo.co.jp 13 14 2 90% 3 93% 2 10% 40% 40% 15% 5% 3) 2 4) 5)

More information

IPSJ SIG Technical Report Vol.2016-CE-137 No /12/ e β /α α β β / α A judgment method of difficulty of task for a learner using simple

IPSJ SIG Technical Report Vol.2016-CE-137 No /12/ e β /α α β β / α A judgment method of difficulty of task for a learner using simple 1 2 3 4 5 e β /α α β β / α A judgment method of difficulty of task for a learner using simple electroencephalograph Katsuyuki Umezawa 1 Takashi Ishida 2 Tomohiko Saito 3 Makoto Nakazawa 4 Shigeichi Hirasawa

More information

Instability of Aerostatic Journal Bearings with Porous Floating Bush at High Speeds Masaaki MIYATAKE *4, Shigeka YOSHIMOTO, Tomoaki CHIBA and Akira CH

Instability of Aerostatic Journal Bearings with Porous Floating Bush at High Speeds Masaaki MIYATAKE *4, Shigeka YOSHIMOTO, Tomoaki CHIBA and Akira CH Instability of Aerostatic Journal Bearings with Porous Floating Bush at High Speeds Masaaki MIYATAKE *4, Shigeka YOSHIMOTO, Tomoaki CHIBA and Akira CHIBA Department of Mechanical Engineering, Tokyo University

More information

1 2 1 2012 39 1964 1997 1 p. 65 1 88 2 1 2 2 1 2 5 3 2 1 89 1 2012 Frantzen & Magnan 2005 2010 6 N2 2014 3 3.1 2015 2009 1 2 3 2 90 2 3 2 B1 B1 1 2 1 2 1 2 1 3.2 1 2014 2015 2 2 2014 2015 9 4.1 91 1 2

More information

The Japanese Journal of Psychology 2000, Vol. 71, No. 3, Emotion recognition: Facial components associated with various emotions Ken Gouta and

The Japanese Journal of Psychology 2000, Vol. 71, No. 3, Emotion recognition: Facial components associated with various emotions Ken Gouta and The Japanese Journal of Psychology 2000, Vol. 71, No. 3, 211-218 Emotion recognition: Facial components associated with various emotions Ken Gouta and Masakazu Miyamoto (Department of Psychology, Faculty

More information

untitled

untitled () No.4 2006 pp.50-61 1 1 ( 020-0193 152-52) 2004 2004 11 737 364 Yahoo! 35%2004 10% 39% 12%2003 15% 21% 2004 : Victoria(2001) 1989 Loma Prieta ( 2004) (disaster subculture)( 19972000 ) (2004)1997 7 10

More information

Public Pension and Immigration The Effects of Immigration on Welfare Inequality The immigration of unskilled workers has been analyzed by a considerab

Public Pension and Immigration The Effects of Immigration on Welfare Inequality The immigration of unskilled workers has been analyzed by a considerab Public Pension and Immigration The Effects of Immigration on Welfare Inequality The immigration of unskilled workers has been analyzed by a considerable amount of research, which has noted an ability distribution.

More information

NL10

NL10 Information September, 2006 1 2 Japanese Association for Molecular Target Therapy of Cancer News Letter No.10 September, 2006 3 2006 4 Japanese Association for Molecular Target Therapy of Cancer News Letter

More information

1 HLA MHC 2017; 24 (2) HLA HLA 1967 HLA HLA HLA HLA 1980 HLA HLA ABO HLA 2000 HLA DSA 2010 HLA HLA HLA HLA HLA HLA HLA HLA HLA GVHD HLA HLA

1 HLA MHC 2017; 24 (2) HLA HLA 1967 HLA HLA HLA HLA 1980 HLA HLA ABO HLA 2000 HLA DSA 2010 HLA HLA HLA HLA HLA HLA HLA HLA HLA GVHD HLA HLA Major Histocompatibility Complex 2017; 24 (2): 150 157 抄録集 1 HLA 2017 5 13 150 1 HLA MHC 2017; 24 (2) HLA 1960 1964 HLA 1967 HLA HLA HLA HLA 1980 HLA HLA ABO HLA 2000 HLA DSA 2010 HLA HLA HLA HLA HLA HLA

More information

小児感染免疫第25巻第2号

小児感染免疫第25巻第2号 2013 Vol. 25No. 2175 44 1972 28 1 Kikuchi s diseasekikuchifujmoto diseasehistiocytic necrotizing lymphadenitis Histiocytic necrotizing lymphadenitis, Kikuchi s disease, KikuchiFujimoto disease, subacute

More information

79 Author s E-mail Address: marluna@shoin.ac.jp Consideration of food education needs that parents ask for nurseries MIYAMOTO Keiko Faculty of Human Sciences, Kobe Shoin Women s University Abstract 1 100

More information

e-learning station 1) 2) 1) 3) 2) 2) 1) 4) e-learning Station 16 e-learning e-learning key words: e-learning LMS CMS A Trial and Prospect of Kumamoto

e-learning station 1) 2) 1) 3) 2) 2) 1) 4) e-learning Station 16 e-learning e-learning key words: e-learning LMS CMS A Trial and Prospect of Kumamoto e-learning station 1) 2) 1) 3) 2) 2) 1) 4) e-learning Station 16 e-learning e-learning key words: e-learninglms CMS A Trial and Prospect of Kumamoto University e-learning Station Hiroshi Nakano 1) Kazuhisa

More information

マスコミへの訃報送信における注意事項

マスコミへの訃報送信における注意事項 逃 げようとする 変 異 型 HIV と 追 いかける 免 疫 の 攻 防 を 結 晶 構 造 レベルで 解 明 1. 発 表 者 : 東 京 大 学 医 科 学 研 究 所 附 属 先 端 医 療 研 究 センター 感 染 症 分 野 教 授 岩 本 愛 吉 2. 発 表 のポイント: ヒト 免 疫 不 全 ウイルス(HIV)の 変 異 とヒトの 免 疫 防 御 能 の 攻 防 を 分 子 レベルで

More information

2014Vol.63No.4p.383393 Thermal environment for health and safety Hirohumi HAYAMA Masaya SAITO Haruka MIKAMI Faculty of Engineering, Hokkaido University School of Design, Sapporo City University Graduate

More information

狂牛病調査第2巻1章,2章.doc

狂牛病調査第2巻1章,2章.doc 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 2.1 A LD50/30mg () 10 ND 1 2.8 ND ND ND 11 ND 2.3 1.0 ND ND 11 ND ND 1.3 1.7 ND 13 ND

More information

52-2.indb

52-2.indb Jpn. J. Health Phys., 52 (2) 55 60 (2017) DOI: 10.5453/jhps.52.55 * 1 * 2 * 2 * 3 * 3 2016 10 28 2017 3 8 Enhancement of Knowledge on Radiation Risk Yukihiko KASAI,* 1 Hiromi KUDO,* 2 Masahiro HOSODA,*

More information

Key words : Adverse reactions, Egg allergy, IgG antibody, Mills allergy, FAST

Key words : Adverse reactions, Egg allergy, IgG antibody, Mills allergy, FAST Key words : Adverse reactions, Egg allergy, IgG antibody, Mills allergy, FAST 13) Danaeus, A., Johansson, S. G. O., Foucard, T. & Ohman, S.: Clinical and immunogical aspects of food allergy in childhood.

More information

e.g., Mahoney, Vandell, Simpkins, & Zarrett, Bohnert, Fredricks, & Randall2010 breadth intensitydurationengagement e.g., Mahone

e.g., Mahoney, Vandell, Simpkins, & Zarrett, Bohnert, Fredricks, & Randall2010 breadth intensitydurationengagement e.g., Mahone 2014 25 4 453465 1 670 6 1 2 2008, 2009 2002 e.g., 2002; 1999 100 1 2 2013; 2002; 1999 1 2007 2009 2006; 20082006 2013 454 254 e.g., Mahoney, Vandell, Simpkins, & Zarrett, 2009 1 23 2013 Bohnert, Fredricks,

More information

Title Author(s) Kobe University Repository : Kernel 認知症高齢者と家族介護者間のコミュニケーション改善のために訪問看護師が実施した支援のプロセス : 共依存事例について (The Support Process in Improving Communication Between Elderly with Dementia and the Family

More information

自殺の経済社会的要因に関する調査研究報告書

自殺の経済社会的要因に関する調査研究報告書 17 1 2 3 4 5 11 16 30,247 17 18 21,024 +2.0 6 12 13 WHO 100 14 7 15 2 5 8 16 9 10 17 11 12 13 14 15 16 17 II I 18 Durkheim(1897) Hamermesh&Soss(1974)Dixit&Pindyck(1994) Becker&Posner(2004) Rosenthal(1993)

More information

本文/YA9255C

本文/YA9255C pp. E- -SH X in vitro in vivo -SH Structure-based drug development and medical biological application of cathepsin specific inhibitors Nobuhiko Katunuma Institute for Health Sciences, Tokushima Bunri University,Nishihamabouji,

More information

自然言語処理16_2_45

自然言語処理16_2_45 FileMaker Pro E-learning GUI Phrase Reading Cloze. E-learning Language Processing Technology and Educational Material Development Generating English Educational Material using a Database Software Kenichi

More information