第14〜15回 T細胞を介する免疫系.pptx

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1

2

3 MBL CD8 CD4

4 8.1

5 8.2

6 5.20

7 8.3

8

9

10

11 8.10

12 8.18 B7 CD28 CD28 B7 CD28

13 NK

14 Toll(TLR) LBP! LPS dsrna ssrna TLR1/2/6! TLR4 TLR5 TLR3 TLR7/9 CD14! JNK/p38! MyD88! IRAK! TRAF! NFκB! TNF-α +

15 Toll(TLR) LPS dsrna ssrna LBP! TLR1/2/6! TLR4 TLR5 TLR3 TLR7/9 CD14!

16

17 MHC分子へのペプチド抗原の結合過程 図5.20

18 8.11

19 8.17

20

21 IFN-γ IL-12 IFN-γ CD4 TGF-β IL-4 IL-6 TGF-β Th1 Th2 Th17 IL-4, IL-5 IL-17, IL-21 TGF-β, IL-10 Treg Treg Treg

22

23 APC: antigen presenting cell)

24

25 8.4 CD62L 8.7

26 24 weeks old! Molano, et al, clinical immunol, 2003

27 68.2 " 6 " 12 " 24 " 8.1" 61.9" 4.8" 37.7 " 7.6" CD62L 6.0" 32.1" 17.7" 22.0" 17.8" 29.1" 15.7" 18.8" 22.8" 1.0 " 31.9 " 4.7" 2.9" 43.0" 1.4" 50.7" 3.8" 90.5 " CD44

28

29

30

31

32

33 LT LT LT: GM-CSF:- CXCL2:

34

35

36 B7 CD28 CD28 B7 CD28

37 IgM Hyper-IgM Syndrome (HIGM) B CSR SHM IgM " HIGM Type 1~6 " " IgG IgA " " /3 4 "

38 Type" HIGM Type 1!!!! HIGM Type 2!!! HIGM Type 3!!! HIGM Type 4!!! HIGM Type 5!!! HIGM Type 6!! IgM Hyper-IgM Syndrome (HIGM) Mutation (genetic inheritance)" CD40-L " (X-linked R)" " " AID (AR)! " " CD40 (AR)" " " Unknown (AR?)" " " UNG (AR)" " " NEMO " (X-linked R)" NFκB " A co-stimulatory molecule on T cells. Altered T cell-b cell interaction. " " An essential factor for SHM and CSR. C 5." " A co-stimulatory on B cells. Altered T cell-b cell interaction.." " Intact SHM but altered CSR; It is supposed that." " R C." " Mutated NEMO is u "

39 IgM " T " HIGM Type 1! HIGM Type 3! HIGM Type 6! κ κ B " HIGM Type 2! HIGM Type 5! HIGM Type 4! "

40 CD8 CD

41 CD8 CD

42 CD

43 CD

44 CD

45 CD

46

47

48 Vol.2 No.12

49 b(haemophilus influenzae: Hi ) Hi a~f 6 b (Hib) 500 Hib (Streptococcus pneumoniae: ) (H22 013

50 IgG 11

51 class II Th2 IgG Th2

52 + IgM IgM IgM IgG MHC class II Th2 MHC class II Th2 IgG

53 + IgM IgM IgM IgG MHC class II Th2 MHC class II Th2 IgG

54

55 Vol.2 No.12

第86回日本感染症学会総会学術集会後抄録(I)

第86回日本感染症学会総会学術集会後抄録(I) κ κ κ κ κ κ μ μ β β β γ α α β β γ α β α α α γ α β β γ μ β β μ μ α ββ β β β β β β β β β β β β β β β β β β γ β μ μ μ μμ μ μ μ μ β β μ μ μ μ μ μ μ μ μ μ μ μ μ μ β

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2 CSR - 20312-1819 2 CSR - 3 1 2 3 ( ) 4 - A 5 B C 5. 6 7 8 9 8. - 9. - 58 9 8 25 16, 7 5 2,500 ( ) 0751,920 07125,2000815,700 10 11 10. - - 12 13 - - 14 13. - - 15 1 61 171228 1843 16F 1 80 25 55 ( 3-21-5 http://akan-nt.or.jp

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