2つの疑問

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1 Daiichi College of Pharmaceutical Sciences 22-1 Tamagawa-cho, Minami-ku,Fukuoka , Japan 1. B

2

3 G. Edelman 3. H (heavy chain) L (light chain) 2 4 S-S

4 R. Porter papain) N Fab(Fragment antigen binding) C Fc(Fragment crystallizable) Fab Fc Fab N Fc C 4.

5 S-S110 5.

6 Complemetarity-determining region, CDR) 6.

7 antigenic determinant epitope (88-58) (85-31) (89-33) (83-58)

8 6. V C Fc 7.

9 H H 8. 5 IgG II III Rh IgG IgM 10 5 ABO

10 IgM IgA 80 I A I A IgA IgA IgA IgA J IgA Sc IgA Sc IgA IgA IgA IgASc 390,000

11 IgA 170,000 IgA2 J IgE IgD B 9.

12 1 1 Fab 2 Fab Fab

13 11.1 VH CH AA/110AA AA/110AA IgM IgD IgG AA/110AA IgE IgA L( 90AA/110AA AA/110AA

14 Ig) IgM IgG IgD IgE IgA IgM IgMIgG IgM IgG IgD IgE IgA IgD

15 H TGF- BIgA IL-4 IFN-IL-4 BIgE ex) IL4 IgM IgE INF IgM IgG M)E) 2. a. b. c. IgG d.(monoclonal) (polyclonal)

16 2. a. b. c. IgG d.(monoclonal) (polyclonal) 3. a. H b. L c. IgE d. IgA 3. a. H b. L c. IgE d. IgA 4. a IgE b IgG c IgA d IgM 4. a IgE b IgG c IgA d IgM 2007

17 121 a HL 2 1 b Fab Fc c 5H d Fc FabFab a HL 2 1 b Fab Fc c 5H d Fc FabFab a B b H c IgM d IgA a B b H c IgM d IgA a IgM b IgE c IgG IgM d IgA Ig e IgMIgA -1 1 (a b c) 2 (a b d) 3 (a b e) 4 (b c d) 5 (b c e) 6 (c d e) a IgM b IgE c IgG IgM d IgA Ig e IgMIgA -1 1 (a b c) 2 (a b d) 3 (a b e) 4 (b c d) 5 (b c e) 6 (c d e)

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