Инактивация микроорганизмов в среде сверхкритического CO2

Transcription

1 , ﾁ CO ｨｮ , ｨｮ ｨ, ｨｦ, ｨ 0108ｨｨｨｪ*, ｨｮ0804ｨｨｨｪ, ｨ ｨｪｨｨｨｺ0609ｨ, ｨｮｨｬ070609, ｨｬｨｨ0106ｨｪ0609ｨ ｨｨｨｬ ｨｪ09ｨｰｨ ｨｪｨｰｨｨｨｪ0609ｨ, 01ｨ ｨｰ ﾂｨｨｨｪｨ, ｨｨ ｰ04ｨ 01ｨｨ020904ｨｦ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｨｨｬ ｨｨｨｪｨ ｱ03, 05ｨ ｨｪｨｺｨｰ-0302ｨｰ0208 ｨ ｨｮ0800, ｨｨ07 *shadrin@atom.nw.ru ｨｰｨｮ07ｨｨ05ｨ ｨ ｨｺ02ｨｨ ｨ ｨｰｨ ｨｪ ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ ｨ ｨｪｨｨｨｦ ｨｬ0603ｨｪ06 09ｨｰ02ｨｦ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ ｨ ｨｪｨｨ02ｨｬ 09 ｨｺｨ ﾂ0209ｨｰ ｨｺ ｨｨ ﾂｨｪ (00green03), ｨ 05ｨｹｨｰ0208ｨｪｨ ｨｰｨｨ09ｨｪ ｨｰ08ｨ 01ｨｨ02ｨｨ06ｨｪｨｪ04ｨｬ, 09ｨｰ0208ｨｨ05ｨｨ04ｨｮ06ｨｴ ｨ 0002ｨｪｨｰｨ. 02ｨ 09ｨｮ0301ｨ 06ｨｰ ｨｪｨｪ ｨｨｨｰ0208 ｨ ｨｰｨｮ0802 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ04 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｨ 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｹ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 06ｨｰ 01ｨ ｨｪｨｨ07, ｨｰ02ｨｬ070208ｨ ｨｰｨｮ0804, ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ, 09ｨｨ01ｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609, 06ｨ 08ｨ ｨ ｨ ｨｰ0409ｨ 02ｨｬ ｨｬｨ ｨｰ0208ｨｨｨ 05ｨ ｨｨ ｨ 0108ｨｮ00ｨｨ01 00ｨ ｨｺｨｰ ﾂ ｨ : ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ CO 2, ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07, 09ｨｰ0208ｨｨ05ｨｨ04ｨ 02ｨｨ07, ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｹ040609ｨ ｨｪｨｨ ｨ ｨｪｨｨ02ｨｬ ｨｰ ｨｪｨｨｨｬ ｨｨ04 09ｨ ｨｬ ｨｺｨｰｨｨ09ｨｪ ｨ ｨｪ06ｨｦ 07ｨ 09ｨｰ0208ｨｨ04ｨ 02ｨｨｨｨ ｨｨ/ｨｨ05ｨｨ 09ｨｰ0208ｨｨ05ｨｨ04ｨ 02ｨｨｨｨ 03ｨｨ01ｨｺｨｨ 01 ｨｨ ｨｰ ｨｬｨ ｨｰ0208ｨｨｨ , ｨｺ06ｨｰ ｨ ｨｪ ｨｪ0609ｨｰｨｹ06 ｨｨ05ｨｨ ﾂｨ 09ｨｰｨｨ ﾂｨｪ06 04ｨ ｨｬ02ｨｪｨｨｨｰｨｹ 03ｨｨ0806ｨｺ06 ｨｨ ｨｹ04ｨｮ02ｨｬｨｮ06 ｨｰ0208ｨｬ0606ｨ 08ｨ ｨ 06ｨｰｨｺｨｮ ｨｬ06ｨｰ0807 ｨｪｨ ｨｰ06, ﾂｨｰ ｨ ｨｪ0609ｨｰｨｹ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｰｨｹ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ04 ｨｨ ｨｰｨｪｨ ｨｺｨ [1], ｨｰ0605ｨｹｨｺ ｨｪ ｨｨ ｨｰ ｨ ｨｪ ｨ 04ｨｦ ｨｪｨ ｨｮ ﾂｨｪ04ｨｦ ｨｨ 05ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｨｨｪｨｰ ｨｺ 0708ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺ06ｨｬｨｮ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ06 01ｨ ｨｪｨｪ ｨｬ02ｨｰ0601ｨ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ02ｨｦ 0706ｨｪｨｨｨｬｨ 02ｨｰ0907 ﾂｨ 09ｨｰｨｨ ﾂｨｪｨ 07 ｨｨ05ｨｨ ｨｪｨ ｨｰ ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ04ｨｬ 0902ｨｴ0209ｨｰ0906ｨｬ ｨｨ05ｨｨ ｨ 0002ｨｪｨｰ06ｨｬ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ, 09 ｨｰ06ｨｬ ﾂｨｨ ｨｨ000208ｨ 02ｨｨ07, ｨｰ ｨｰ ｨ ｨｪ0609ｨｰｨｨ ｨｺ 08ｨ 04ｨｬｨｪ060302ｨｪｨｨ06, ｨｨ ｨｺｨ ｨｺ ｨｰ09ｨｨ02 05ｨｰ ｪ 0706ｨｰ ｨ ｨｰ060002ｨｪｨｪ0609ｨｰｨｨ ｨｨ ｨ ｨｪ0609ｨｰｨｨ ｨｺ 09ｨｨｨｪｨｰ0204ｨｮ ｨｪ ｨｴ0209ｨｰ09. 02ｨｪｨ ｨｰ0907 ﾂ ﾂｨ ｨｦｨｪ06 09ｨ 03ｨｪ04ｨｬ 00ｨ ｨｺｨｰ060806ｨｬ ｨｨｨｴ020906ｨｦ ｨｨ 00ｨ 08ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｬ ｨｪｨｪ06 09ｨｰ02ｨｦ, ｨ ｨｰｨ ｨｺ ｨｮ00ｨｨ01 06ｨ 05ｨ 09ｨｰ02ｨｦ, ｨ ｨｪｨｪ ｨ ｨｪ02ｨｪｨｨ02ｨｬ ｨｹ07 ｨｪｨ ｨｪｨｨ ｨｬ06ｨｰ0807 ｨｪｨ ｨｰ06, ﾂｨｰ06 09 ｨｰ02 ﾂ02ｨｪｨｨ ｨｬ02ｨｪｨｨ 08ｨ 0408ｨ ｨ ｨ ｨｰ0409ｨ 05ｨｨ09ｨｹ ｨｪ ｨｰ0201ｨｪ ｨｨｨｨ 09ｨｰ0208ｨｨ05ｨｨ04ｨ 02ｨｨｨｨ, 09 ｨｰ06ｨｬ ﾂｨｨ ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ 00ｨｨ04ｨｨ ﾂ0209ｨｺｨｨ02 ｨｬ02ｨｰ [2], 09ｨ ｨｬ04ｨｬ ｨｺｨｰ ｨｨ09ｨｪ04ｨｬ ｨｬ02ｨｰ060106ｨｬ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｨ ｨｰ0907 ｨｰ0208ｨｬｨｨ ﾂ02 09ｨｺｨ 07 09ｨｰ0208ｨｨ05ｨｨ04ｨ 02ｨｨ ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ06 ｨｰ0208ｨｬ0606ｨ 08ｨ ｨ 06ｨｰｨｺｨ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ ｨｨ0702ｨｰ ｨｪｨ ｨｺｨ ﾂ0209ｨｰ ｨｮｨｺｨｰ0609, ｨｮｨｬ02ｨｪｨｹ03ｨ 07 ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｨｨｰｨ ｨｬｨｨｨｪ0609, ｨｮ01ｨｮ0103ｨ 02ｨｰ 07ｨｨｨｰｨ ｨｰ0205ｨｹｨｪ ｨｦ09ｨｰ09ｨ, 09ｨｪ0203ｨｪｨｨｨｦ 09ｨｨ01, ｨｰ, 09ｨｺｨｮ09 ｨｨ ｨｰ ｨｰ06ｨｬｨｮ 09 ｨｰ ｨｮ ﾂｨ 0701, ｨｺ060001ｨ ｨｰ0208ｨｬ0606ｨ 08ｨ ｨ 06ｨｰｨｺｨ ｨｪ ｨｬ0603ｨｪｨ, 06ｨ 04 ﾂｨｪ ｨｨ010601ｨｨｨｰ0907 ｨｨ ｨｹ040609ｨ ｨｰｨｹ ｨ 05ｨｹｨｰ0208ｨｪｨ ｨｰｨｨ09ｨｪ0402 ｨｪ02ｨｰ0208ｨｬｨｨ ﾂ0209ｨｺｨｨ02 ｨｬ 02ｨｰ060104, ｨｰｨ ｨｺｨｨ02 ｨｺｨ ｨｺ ｨｨ0108ｨ ｨｰｨ 02ｨｨ07, ｨｪ0602 ｨｺ06ｨｪ ｨｨ080609ｨ ｨｪｨｨ02 ｨｨ ｨ ｨｪｨｨ ｨｪｨ ｨｺ06 01 ｨ ｨｪｨｪ0402 ｨｬ02ｨｰ ｨｰｨ 06ｨｰ0907 ｨｬｨ ｨｺｨｰｨｨ09ｨｪ04ｨｬｨｨ ｨ ｨｪｨｨｨｨ 08ｨ 04ｨｬｨｪ060302ｨｪｨｨ07 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609 [3] ｨｪ ｨｬ ｨｰ09ｨｨ02 ｨ ｨｪｨｰｨｪ ｨｰｨ ｨｨ ｨｰ09ｨ ｨｨ ｨｮｨｺｨｰ ｨｨｨｰｨ ｨｪｨｨ07 ｨｨ 00ｨ 08ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ ｨｨｨｦ ｨ ｨｪ 0206ｨ ｨｨｨｬ0609ｨｰｨｹ 09 08ｨ 04-3

2 ｨｮ , ｨｮ ｨ, ｨｦ, ｨ 0108ｨｨｨｪ, ｨｮ0804ｨｨｨｪ, ｨ ｨｪｨｨｨｺ0609ｨ, ｨｮｨｬ070609, ｨｬｨｨ0106ｨｪ0609ｨ 08ｨ ｨ 06ｨｰｨｺ02 ｨ ｨｺｨｰｨｨ09ｨｪ0401 ｨｪ02ｨｰ0208ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｬ02ｨｰ ｨｰ0208ｨｨ05 ｨｨ04ｨ 02ｨｨｨｨ, ｨｮ ｨｰ ｨｴｨｨ ｨｰ0802ｨ ｨｪ0609ｨｰ07ｨｬ 0804ｨｪｨｺｨ ｨｹ040609ｨ ｨｪｨｨ ｨｺ ｨｨ ｨｰ ｨ ｨｰｨｨ ﾂ0209ｨｺ ｨ ｨｪｨｨ07, ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ ｨｮ05ｨｹ09ｨｨ08ｨｮ06ｨｴｨｨ ｨｺｨｰ08ｨｨ ﾂ0209ｨｺｨｨ ｨｦ, 08ｨ 01ｨｨｨ 02ｨｨ06ｨｪｨｪ ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 ｨｨ05ｨｨ 0906 ﾂ02ｨｰｨ ｨｪｨｨ02 05ｨｰｨｨ01 ｨｬ02ｨｰ ｪ ｨｰ0605ｨｹｨｺ06 ｨｪ02ｨｺ06ｨｰ ｨｨ04 ｨｪ02ｨｰ02 08ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｬ02ｨｰ , ｨｨ ｨ ｨｪｨｪ ｨｪ ｨｬ07 09 ｨｺｨ ﾂ0209ｨｰ0902 ｨ 05ｨｹｨｰ0208ｨｪｨ ｨｰｨｨ09ｨｪ 0401 ｨｰ0208ｨｬ0606ｨ 08ｨ ｨ 06ｨｰｨｺ02 [3]. 0201ｨｪｨ ｨｺ ｨｨｨｬ02ｨｪ02ｨｪｨｨ ｨｮｨｺｨ 04ｨ ｨｪｨｪ0401 ｨｬ02ｨｰ ｨｬ ｨｪｨｪ0401 ｨｬｨ 0903ｨｰｨ ｨ ｨ 01 06ｨｺｨ 04ｨ ｨｹ ｨｬｨ ｨｨ000601ｨｪ04ｨｬ ｨｮ 06ｨ ｨｲ02ｨｺｨｰｨｨ09ｨｪ ｨｨ ﾂｨｨｨｪ: ｨｺｨｨ02 ｨｺｨ 07ｨｨｨｰｨ 05ｨｹｨｪ ｨ ｨｰ08ｨ ｨｰ04, ｨｰ0607ｨｴｨ 07 05ｨｺ090705ｨｮｨ ｨｰｨ 02ｨｨ07, ｨｪｨｨ04ｨｺｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨｨｪｨ ｨｺｨｰ ｨｨ09ｨ 02ｨｨｨｨ ｨｬｨｨｨｺ ｨｨ ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪｨ 07 ｨ ｨ 09ｨｪ0609ｨｰｨｹ ｨｪ ｨｰ0902ｨｪｨｪ ｨｬ07 08ｨ ｨ 06ｨｰ04. 06ｨ ｨｺ, ｨｪｨ 0708ｨｨｨｬ0208, 06ｨ 08ｨ ｨ 06ｨｰｨｺｨ 0708ｨｨ ｨｺ06ｨｬ 00ｨｨ ｨｰｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｬ 01ｨ ｨｪｨｨｨｨ ｨｨ05ｨｨ 01ｨｨｨｪｨ ｨｬｨｨ ﾂ0209ｨｺ06ｨｬ 01ｨ ｨｪｨｨｨｨ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ Listeria monocytogenes, Salmonella typhimurium [4] ｨｨ Esherichia coli (E. coli) [5] ｨｨ05ｨ 09ｨｹ 0708ｨｨ 2000 ｨｨ 6000 ｨ ｨｰｨｬ ｨｨ 09 ｨｰ02ｨｬ, ﾂｨｰ06 09 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ 07 ｨｰ0802ｨ 0609ｨ ｨｪｨｨ07 ｨｺ ｨｬ ｨｪｨｪ06ｨｬｨｮ 06ｨ 0608ｨｮ010609ｨ ｨｪｨｨ06 ｨｪ ｨｰ ｨｨ ｨｹ040609ｨ ｨｰｨｹ 01ｨ ｨｪｨｨ ｨ ｨｰｨｬ, 05ｨｰ06ｨｰ ｨｬ02ｨｰ0601 ｨｺ08ｨ ｨｦｨｪ ｨｪ ｨｨｨｬ02ｨｪｨｨｨｰｨｹ ｨｬ ｨｪｨｪ06ｨｬ ｨｬ ｨ 0903ｨｰｨ ｨ 02 [6, 7]. 0005ｨ 03ｨｪｨ 07 ｨｰ0208ｨｬ0606ｨ 08ｨ ｨ 06ｨｰｨｺｨ ｪ 02ｨｴ ｨｨｨｪ ﾂｨ 09ｨｰ06 ｨｨ ｨｹ04ｨｮ02ｨｬ04ｨｦ ｨｬ02ｨｰ 0601 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ [8]. 0906ｨｰ ｨｪｨｨ ｨ 03ｨｪ06ｨｦ ｨｰ0208ｨｬ0606ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ 0708ｨｨ ｨｰ02ｨｬ070208ｨ ｨｰｨｮ0802 ｨｪｨｨ 縺05 (010204ｨｨｨｪ0002ｨｺ02ｨｨ07) [2] ｨｨ 0708ｨｨ090601ｨｨｨｰ ｨｺ 08ｨ 0408ｨｮ0302ｨｪｨｨ ｨ 07ｨ ｨｰ060002ｨｪｨｪ0401 ｨｨ05ｨｨ 0108ｨｮ00 ｨｨ ｨ 09ｨｪ0401 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609, ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ 0708ｨｨ 05ｨｰ06ｨｬ ｨｪ ｨｨｨ ｨ 06ｨｰ [9] ｨｮ0006ｨｦ 09ｨｰ060806ｨｪ04, 05ｨｰ06ｨｰ ｨｨ ｨｰ02ｨｬ070208ｨ ｨｰｨｮ08ｨ 縺05 (09ｨｰ0208ｨｨ05ｨｨ04ｨ 02ｨｨ07) [2] 08ｨ 0408ｨｮ03ｨ 02ｨｰ ｨｬ04 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609 [9]. 0201ｨｪｨ ｨｺ06 09ｨｰ0605ｨｹ ｨｺｨｨ02 ｨｰ02ｨｬ070208ｨ ｨｰｨｮ ｨｺｨｮｨｰ 04ｨ 0906ｨ 06ｨｦ ｨ ｨｪｨｪ ｨｰ0208ｨｬ0606ｨ 08ｨ ｨ 06ｨｰｨｺ06ｨｦ ｨｪ ｨｰｨ ｨｰｨｺｨｨ, 06ｨｰｨｬ02 ﾂ02ｨｪｨｪ [10] ｨｨ 09 05ｨｰｨｨｨｬ 08ｨ 0409ｨｨｨｰｨｨ02 ｨ 05ｨｹｨｰ0208ｨｪｨ ｨｰｨｨ09ｨｪ ｨｬ02ｨｰ0601ｨ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ ｨｨ06ｨｺ09ｨｨ01ｨ ｨｮ ｨ ( ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺ06ｨｬ, 03ｨｨ01ｨｺ06ｨｬ ｨｨ 00ｨ ｨ 08ｨ 04ｨｪ06ｨｬ ｨｰ 0607ｨｪｨｨ0701), ｨｺ06ｨｰ060804ｨｦ 09 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ 05ｨｨ0302ｨｪ ﾂｨｨ090502ｨｪｨｪ ｨｪ ｨｰｨ ｨｰ ｨｺ0609, ｨｦ09ｨｰ0902ｨｪｨｪ0401 ｨｰ0208ｨｬｨｨ ﾂ0209ｨｺｨｨｨｬ ｨｨ 0609ｨｰｨ 05ｨｹｨｪ04ｨｬ ｨｬ02ｨｰ0601ｨ ｨｬ, ｨｰｨ ｨｰ ｨｪ020906ｨｬｨｪ02ｨｪｨｪ 04ｨｦ ｨｨｨｪｨｰ ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪ06 ｨ 0605ｨｹ ﾂｨｨ ｨｰｨ ｨｰ02ｨｦ ｨｨ 06ｨ ｨｪｨ ｨｰ02ｨｬｨｮ ｨｨ ｨ ｨｪｨｨｨｦ 09 01ｨ ｨｪｨｪ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ, ｨｨ ｨｺ06ｨｰ ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ 06ｨ Perrut [1 1], Spilimbergo [12], Koutchma [13]. 09ｨｨ ｨｨ ﾂ0209ｨｺ ｨｦ09ｨｰ09ｨｨ ｨｪｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ04 02ｨｨ06ｨｺ09ｨｨ01 ｨｮ ｨ ｪ 05ｨｰ06 ｨｪ02ｨｰ06ｨｺ09ｨｨ ﾂｨｪ04ｨｦ 00ｨ ｨ ｨｪｨｰｨｨｨｬｨｨｨｺ0806ｨ ｨｪ04ｨｬｨｨ ｨｦ09ｨｰ09ｨ ｨｬｨｨ, ｨｺ06ｨｰ060804ｨｦ ﾂｨ 09ｨｰ ｨｨ09ｨｮｨｰ09ｨｰ09ｨｮ02ｨｰ 09 07ｨｨｨｴ ｨｮｨｺｨｰｨ 01 ｨｨ ｨｪｨ 07ｨｨｨｰｨｺｨ 01 [14] ｨｰｨｪ06, ﾂｨｰ06 ｨ ｨｪｨｰｨｨｨｬｨｨｨｺ0806ｨ ｨｪｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ CO 2 04ｨ 09ｨｨ09ｨｨｨｰ ｨｪ02 ｨｰ0605ｨｹｨｺ06 06ｨｰ 01ｨ ｨｪｨｨ07 ｨｨ ｨｰ02ｨｬ070208ｨ ｨｰｨｮ0804 [15, 16], ｨｪ06 ｨｰｨ ｨｺ ｨｰ ｨ ｨｰ0607ｨｪｨｨ07 (00ｨ 04, 03ｨｨ01ｨｺ0609ｨｰｨｹ ｨｨ05ｨｨ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｨ01) ｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 08ｨ 09ｨｰ ｨｪｨｪ CO 2 09 ｨｨ ｨｮ02ｨｬ06ｨｬ 06ｨ 08ｨ [14] ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ CO 2 ( ) [17] 06ｨ 05ｨ 01ｨ 02ｨｰ ｨｦ 08ｨ 09ｨｰ090608ｨｨｨｬ0609ｨｰｨｹ06 ｨｨ ｨｪｨｨｨｺｨ 06ｨｴ02ｨｦ ｨ ｨｪ0609ｨｰｨｹ06, ﾂｨｰ ｨｰ 02ｨｬｨｮ ｨｨｨｰｨｹ ﾂ ｨｺ0502ｨｰ06 ﾂｨｪｨｮ 06 06ｨ ﾂｨｺｨｮ ｨｨ 09ｨｪｨｮｨｰ08ｨｹ , ｨ 09 ﾂ02ｨｰ 06ｨ 08ｨ ｨ ｨｪｨｨ ｨ ｨ 06ｨｦ ｨｮ000605ｨｹｨｪ06ｨｦ ｨｺｨｨ090506ｨｰ ｨｪｨｨ03ｨ 02ｨｰ ｨｪｨｮｨｰ08ｨｨｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ [18 ｪ20] ｨｬ0603ｨｪ06 01ｨ 0302 ｨｮ01ｨ 0502ｨｪｨｨ02 ﾂｨ 09ｨｰｨｨ ｨｨ ｨｬ ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｺ0502ｨｰｨｺｨｨ ﾂ ｨｨ080609ｨ ｨｪｨｪｨｮ CO 2 ｨｺ0502ｨｰ06 ﾂｨｪｨｮ06 09ｨｰ02ｨｪｨｺｨｮ [21, 22]. 02ｨ ｨｪｨｪ ｨｨ09ｨｰ02ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ ｨ ｨｪｨｨｨｦ 06 ｨｰ06ｨｬ, ﾂｨｰ ｨｨ ｨｰ02ｨｬ070208ｨ ｨｰｨｮ0802 ｨｨ 01ｨ ｨｪｨｨｨｨ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺｨｨ01 (06 ｨｺ08 = 31,2 紊, P ｨｺ08 = 71,1 ｨ ｨｰｨｬ) 06ｨｰ05ｨｨ ﾂｨｪ06 04ｨ ｨｴｨｨｨｴｨ 02ｨｰ ｨｮｨｺｨｰ04 06ｨｰ 06ｨｺｨｨ090502ｨｪｨｨ07, ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｰ 09ｨｨ08ｨｮ0904 ｨｨ ｨ ｨｰ ｨｰ ｨｪ02ｨｺ06ｨｰ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609, ｨ 0405ｨｨ ｨｰｨ ｨｪ ｨｨｨｬ0208ｨｪ ｨｰ ｨｪｨ 04ｨ 01 Jones [23] ｨｨ Daniels [14]. 0201ｨｪｨ ｨｺ06 ｨｰ0605ｨｹｨｺ06 ｨ 05ｨ ｨ ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺｨｨｨｬ 00ｨ ｨｺｨｰ0608ｨ ｨｬ ｨｪ ｨｬ07 ｨｪｨ ｨ ｨ 02ｨｰ ｨ 04ｨｦ ｨｪｨ ｨｮ ﾂｨｪ04ｨｦ ｨｨｨｪｨｰ ｨｺ 0708ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺ06ｨｬｨｮ 0708ｨｨｨｬ02ｨｪ 02ｨｪｨｨ06 01ｨ ｨｪｨｪ ｨｬ02ｨｰ0601ｨ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ, , 07ｨｨｨｴ ｨｬｨ ｨｰ0208ｨｨｨ ｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09 ｨｺｨｨ ｨ 08ｨ ｨｰ ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ 00ｨ ｨｰ0607ｨｪｨｨ07 CO 2 ｨｪｨ 0904ｨｴ02ｨｪｨｨ02 ｨｨｨｬ ｨｨ ｨｮ02ｨｬ ｨ 09ｨｰ090608ｨ ｨｬ060302ｨｰ 0609ｨｮｨｴ0209ｨｰ090507ｨｰｨｹ0907 ｨｪ0209ｨｺ0605ｨｹｨｺｨｨｨｬｨｨ 07ｨｮｨｰ07ｨｬｨｨ: 4

3 1306ｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺ CO 2 ｪ ｨｮ09ｨｺ06ｨｦ CO 2 02ｨｬｨｺ0609ｨｰｨｨ 09 06ｨ 08ｨ ｨｬ [24]; ｪ ｨ ﾂ02ｨｦ 03ｨｨ01ｨｺ CO ｨｬｨｺ0609ｨｰｨｹ 09 ｨｨ ｨｮ02ｨｬ04ｨｬ 06ｨ 08ｨ ｨｬ [25]; ｪ ｨｺ06ｨｬ 0508-CO ｨｮ01 09 ｨｨ ｨｮ02ｨｬ04ｨｬ 06ｨ 08ｨ ｨｬ [18, 19, 26]; 09ｨ 08ｨｨｨ ｨｪｨｰ06ｨｬ ｨｺｨ ｨｰ ｨｮ09ｨｺｨ CO 2 ﾂ ｨｬｨｨｨｺ080600ｨｨ05ｨｹｨｰ08 [18, 19, 27] ｨｰｨｨｨｬｨｨ04ｨ 02ｨｨｨｨ ｨｨ0601ｨｨ ﾂ0209ｨｺ ｨ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ 08ｨ 0408ｨ ｨ ｨ ｨｰ0409ｨ 06ｨｰ0907 ｨｪ , ｨ ｨｺ06ｨｪ06ｨｬｨｨ ﾂｨｪ0402 ｨｰ0201ｨｪ ｨｨｨｨ ｨ ｨ 06ｨｰ02 Spilimbergo [28] ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ ｨｨ05ｨ 09ｨｹ ｨｮｨｪ ｨｪ06ｨｬ ｨｨｨｬ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｪ ｨｪ04ｨｦ 0706ｨｰ06ｨｺ ｨｨ01ｨ ｨ ｨｺｨｰｨｨ0902ｨｪ, ﾂ02ｨｬ 09ｨｰｨ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ [29]. 01ｨ ｨｨｨ ｨｺ ｨｰｨｨ09ｨｪ ｨ ｨ 06ｨｰ04 09 ｨｪ ｨｪ06ｨｬ ｨｨｨｬ ｨｰｨｨ0906ｨｰ06 ﾂｨｪ0402 ｨｺ060506ｨｪｨｺｨｨ ｨｨ05ｨｨ ｨｬ02ｨｬｨ 08ｨ ｨｪ04 (ｨｰｨ ｨｺｨｨ02 ｨｺｨ ｨｺ POROCRIT) [30 ｪ32] ｨ ｨ 06ｨｰｨ 01 Shimoda [21] ｨｨ Ishikawa [30, 33] ｨ ｨ 08ｨ 06ｨｰｨｨ080609ｨ ｨｪｨｨ ｨｰｨｮ07ｨ 06ｨｴ ｨｪｨ ｨ 0405 ｨｮ09ｨｰｨ ｨｪ ｨｪ ｨｨｨ 05ｨｹｨｪ04ｨｦ 00ｨｨ05ｨｹｨｰ08, 0708ｨｨ 05ｨｰ06ｨｬ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 ｨｮ090205ｨｨ ﾂｨｨ05ｨ 09ｨｹ. 05ｨ ｨｪｨｨ02 ｨｪ0209ｨｺ0605ｨｹｨｺ ｨｰ 0607ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪ06 ｨ 0605ｨｹ ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨ ｨ 06ｨｰ 0706 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ06ｨｴ02ｨｬｨｮ 0102ｨｦ09ｨｰ09ｨｨ ｨｪｨ 08ｨ 0405ｨｨ ﾂｨｪ0402 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ04 [34 ｪ38]. 0102ｨｺ06ｨｰ ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｪ ｨ ｨｪｨｪ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｰｨ ｨｰ ｨｨ09ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ ｨｨ ｨｦ09ｨｰ09ｨｨ02ｨｬ ｨｰｨ ｨｪ04 09 ｨｰｨ ｨ 05ｨｨ ｨｪｨ 05ｨｨ04 05ｨｨｨｰ0208ｨ ｨｰｨｮ08ｨｪ ｨ ｨｪｨｪ ｨｺｨ 04ｨ 05, ﾂｨｰ06 E. coli ｨｰ0907 ｨｪｨ ｨｨｨ ﾂｨ 09ｨｰ06 ｨｨ ｨｹ04ｨｮ02ｨｬ04ｨｬ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ06ｨｬ ｨｨ ｨ ｨｪｨｨ07 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｺｨ ｨｺ 09 09ｨｮｨ - [17, 20, 49], ｨｰｨ ｨｺ ｨｨ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺｨｨ01 [20, 22, 31, 49 ｪ51] ｨｮ ｨｨ ｨ ｨｺ, ｨｪｨ 0708ｨｨｨｬ0208, Kamihira ｨ 09ｨｰ0608ｨ ｨｬｨｨ [20] 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 ｨｪｨ ｨｨｨ ｨｺｨ ｨｺｨｰｨｨ09 ｨｪ0609ｨｰｨｹ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ, ｨ ｨｨｨｬ02ｨｪｨｪ ｨ 04 (8-log) 07ｨ 0102ｨｪｨｨ ｨｨ09ｨ 02ｨｬ0609ｨｰｨｨ (CFU/ml ｪ Colony Forming Unit/ml) E. coli, ｨｪｨ ｨ ｨ 02ｨｰ ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ01 08ｨ 09ｨｰ090608ｨ 01 (PS ｪ physiological saline) 0708ｨｨ 06ｨ 08ｨ ｨ 06ｨｰｨｺ02 09ｨｮｨ - ｨｨ05ｨｨ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺｨｨｨｬ (100 ﾂ200 ｨ ｨｰｨｬ, 30 ﾂ45 縺05, 25 ﾂ60 ｨｬｨｨｨｪ) ｨｬ02 ｨｰ060006, 09 08ｨ ｨ 06ｨｰ02 [20] ｨｪ02 06ｨ ｨｪｨ 08ｨｮ03ｨｨ05ｨｨ 06ｨｰ05ｨｨ ﾂｨｨｨｦ 09 ｨｨｨｪｨ ｨｺｨｰｨｨ - 09ｨ 02ｨｨｨｨ 06ｨｰ010205ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ E. coli (ｨｪ02 09ｨｮ090702ｨｪ04ｨｨｨｨ) 00ｨ ｨ 08ｨ 04ｨｪ04ｨｬ (40 ｨ ｨｰｨｬ, 35 縺05) ｨｨ05ｨｨ 03ｨｨ01ｨｺｨｨｨｬ (100 ﾂ200 ｨ ｨｰｨｬ, 20 縺05). 0201ｨｪｨ ｨｺ06 ｨｺ060001ｨ ｨｮ ｨｨ07 ｨ 0405ｨｨ ｨｨ04ｨｬ02ｨｪ02ｨｪ04 ｨｪｨ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺｨｨ02 (100 ﾂ200 ｨ ｨｰｨｬ, 35 縺05), ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 E. coli 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 ｨｮ090205ｨｨ ﾂｨｨ05ｨ 09ｨｹ. 0308ｨｨ 05ｨｰ06ｨｬ ｨ 09ｨｰ0608ｨ ｨｬ ｨｪ02 ｨｮ01ｨ ｨｹ ｨｨｨｰｨｹ, ﾂｨｰ06 ｨｨｨｬ02ｨｪｨｪ06 ｪ 01 09ｨｮ06ｨｺｨｨ09ｨｹ ｨｮ ｨ ｨｨ05ｨｨ ｨ ｨｺ ｨ ｨｪｨｨ02 ｪ 06ｨｺｨ 04ｨ ｨｹ 0708ｨｨ ﾂｨｨｨｪ06ｨｦ 09ｨｰ0605ｨｹ ｨｺ06ｨｦ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ. 06ｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 E. coli 0708ｨｨ 06ｨ 08ｨ ｨ 06ｨｰｨｺ02 07ｨｨｨｴ ｨｮｨｺｨｰ0609 ｨｬ02ｨｪ ｨｺｨｰｨｨ09ｨｪｨ. 06ｨ ｨｺ, 09 08ｨ ｨ 06ｨｰ02 [31] 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ ｨｨ 06ｨ 08ｨ ｨ 06ｨｰｨｺ02 ｨ ｨｹ09ｨｨｨｪ ｨｺｨ (200 ﾂ1000 ｨ ｨｰｨｬ, 34,5 縺05, 10 ｨｬｨｨｨｪ) ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ E. 09oli 0215: ｨｰｨ 09ｨｨ05ｨ ｨｰ0605ｨｹｨｺ06 06ｨｰ 2-log log ｨｮ0006ｨｦ 09ｨｰ060806ｨｪ04, Rasanayagam ｨ 09ｨｰ0608ｨ ｨｬｨｨ [40] 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 ｨｨ ｨｹ040609ｨ ｨｪｨｨ ｨｺｨ ﾂ ｨｬｨｨｨｺ ｨｨ09ｨｰ04ｨｦ 00ｨｨ05ｨｹｨｰ08 (ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪｨ 07 ｨｰ0201ｨｪ ｨｨ07) ｨｰ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｰｨｹ ｨ ﾂ02ｨｬ ｨｪｨ 6-log 07ｨ ｨｰ060002ｨｪｨｪ0401 ｨｨ ｨｪ0207ｨ ｨｰ060002ｨｪｨｪ0401 ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ (E. coli K12, ｨｦ, ｨｺｨｨ090506ｨｬ ﾂｨｪ0401 ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ, E. coli 02157:H7, Salmonella spp. ｨｨ05ｨｨ L. monocytogenes) 0708ｨｨ 06ｨ 08ｨ ｨ 06ｨｰｨｺ02 ｨ ｨｹ09ｨｨｨｪ ｨｺｨ (79 ｨ ｨｰｨｬ, 40 縺05, 2 ｨｬｨｨｨｪ) ｨｬ06ｨｰ0807 ｨｪｨ ｨｰ06, ﾂｨｰ06 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｨｨｴ ｨｮｨｺｨｰｨ ｨｨｨｰ ｨｪ0202, ﾂ02ｨｬ ｨｨ 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ01 08ｨ 09ｨｰ090608ｨ 01, ｨｬｨｪ ﾂｨｨ090502ｨｪｨｪ0402 ｨｨ ｨ ｨｪｨｨ ｨｰ ｨｨ05ｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ. 04ｨ 0408ｨ ｨ 06ｨｰｨ ｨｪ04 ｨｬ02ｨｰ ｨｨ 06ｨ 0608ｨｮ010609ｨ ｨｪｨｨ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ 09 ｨｰｨ ｨｺｨｨ ｨｮｨｺｨｰｨ 01, ｨｺｨ ｨｺ ｨ ｨｹ09ｨｨｨｪ060904ｨｦ 0906ｨｺ [8, 27, 32, 40, 4 7, 52], 07ｨ 0506 ﾂｨｪ04ｨｦ 0906ｨｺ [7, 53 ｪ55], ｨｬ060506ｨｺ06 [7, 27, 35, 48, 50], ｨｰ06ｨｬｨ ｨｰｨｪ04ｨｦ 0906ｨｺ [44, 45], ｨｺ [27], 09ｨｨｨｪ060008ｨ 01ｨｪ ｨｨｨｪ06 [47, 56]. 0002ｨｪｨｹ03ｨ 07, ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪｨ ｨ ｨｺｨｰｨｨ ﾂ02 09ｨｺ ｨｨ ｨｹ040609ｨ ｨｪｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｪｨ ｨ ｨ 02ｨｰ0907 ｨｨ ｨｰ ｨｮｨｺｨｰ0609, ｨｰｨ ｨｺｨｨ01 ｨｺｨ ｨｺ ｨｬ070906, 09 ｨｰ06ｨｬ ﾂｨｨ ｨｰ0208ｨｬｨｨ ﾂ0209ｨｺｨｨ 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ0602 [45, 46], ｨｴｨｨ [8, 46], ｨｰ 06ｨｬｨ ｨｰｨｪｨ 07 07ｨ 09ｨｰｨ [47], ｨ ｨｨ ｨｨｨｬ [29, 38] ｨｬ06ｨｰ0807 ｨｪｨ ｨｰ06, ﾂｨｰ06 ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ ｨｹｨｬｨ ｨｮ09ｨｰ06ｨｦ ﾂｨｨ ｨｰｨｪ060302ｨｪｨｨ06 ｨｺ ｨｪｨ ｨ ｨｪｨｨ06, ｨ ｨｪｨｨ06, 0102ｨｦ09ｨｰ09ｨｨ06 08ｨ 01ｨｨｨ 02ｨｨｨｨ, 01ｨｨｨｬｨｨ- ﾂ0209ｨｺｨｨ ｨｴ0209ｨｰ09 ｨｨ ｨｺｨｨ01 01ｨ ｨｪｨｨｨｦ ( ｨ ｨｰｨｬ 0708ｨｨ ｨｰ02ｨｬ070208ｨ ｨｰｨｮ08ｨ 01 ｨｪｨｨ 縺05), ｨｨ ｨｰｨｪ04 ｨｬｨｪ ﾂｨｨ090502ｨｪｨｪ0402 ｨｮ ｨｪ0402 ｨｨ ｨ ｨｪｨｨ07 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ

4 ｨｮ , ｨｮ ｨ, ｨｦ, ｨ 0108ｨｨｨｪ, ｨｮ0804ｨｨｨｪ, ｨ ｨｪｨｨｨｺ0609ｨ, ｨｮｨｬ070609, ｨｬｨｨ0106ｨｪ0609ｨ ｨｦ09ｨｰ09ｨｨ ｨｪｨ 08ｨ 0405ｨｨ ﾂｨｪ0402 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ04 ｨｨ ｨｬ070208ｨ ｨｰｨｮ08ｨ, 02ｨ ｨｪｨｨ02, ｨｬ07, 00ｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨ 05 ｨ ｨｰｨｬ ｨｬｨｨｨｪ 06ｨ ｨ 05ｨｨ02ｨ ｨｺｨｨ E. coli K12, 25 0; 365 ﾂ ,1 % ｨｰ06ｨｪ [24] Lactobacillus plantarum ATCC8014 E. coli K ; 350; 0; 1,7; ｨ [25] ATCC25253, 400 3,3; 5 Listeria innocua137 Bacillus subtilis 80; ﾂ15 04ｨ 09ｨｰ ｨｨｨｪ000208ｨ [26] Bacillus coagulans, 35; 65; 85 10; 200; 300 ｪ ｨｺ06, ｨ ｨｹ09ｨｨｨｪ060904ｨｦ Bacillus subtilis, 0906ｨｺ, ｨｺ060002, 09ｨｮ07 [27] Bacillus cereus ｨｨ L. monocytogenes 35; 45 7 ﾂ21 0 ﾂ ｨｺ06 (020205ｨｹｨｪ0602, ｨｪｨｪ06ｨｦ 03ｨｨ08ｨｪ0609ｨｰｨｨ, 06ｨ ｨｨ0802ｨｪｨｪ0602) [33] Aspergillus niger 44 ﾂ52 5 ﾂ19 0,25 ﾂ2,1 08ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨｨｦ [39] ( ) 08ｨ 09ｨｰ E. coli, 40 7,9 2, ｨｹ09ｨｨｨｪ060904ｨｦ 0906ｨｺ [40] Salmonella enteritidis, L. monocytogenes ｨｨ Bacillus coagulans, 35; 55 ﾂ ｨ [27] Bacillus subtilis, Bacillus cereus ｨｨ Bacillus subtilis, 25 0 ﾂ ｨｨｨｰｨ ｨｰ0205ｨｹｨｪｨ ｨ, Staphylococcus aureus ｨｰ0609ｨ ｨ [41] E. coli, 20 ﾂ65 50 ｨC 06ｨｺｨ ｨｪｨｹ [42] Micrococcus luteus Salmonella Enteritidis 58 ﾂ60 0,95 30 ﾂ 35 05ｨｺ060805ｨｮ07ｨ 06ｨｰ 07ｨｨ02 [43] Staphylococcus aureus, 25 ﾂ ﾂ210 36; ｨｨｨｬ0208ｨｪ0402 ｨｬｨ ｨｰ0208ｨｨ- [29] Salmonella salford, ｨ 0504, ｨｬ0201ｨｨｨｺｨ ｨｬ02ｨｪｨｰ04, Legionella dunnifii ｨｨ ｨｨｨｬ0705ｨ ｨｪｨｰｨ ｨｪｨｰ04 Bacillus subtilis 7 ﾂ45 75 ﾂ ﾂ ｨｬｨ ｨｰｨｪ04ｨｦ 0906ｨｺ [44] Streptococcus faecalis, 20 ﾂ ﾂ ｨ 0802ｨｪｨ ｨｨｨｪｨｨｨｪｨ [45] Bacillus subtilis Enterococcus faecalis, ｨｨｨｪｨｨｨｪｨ, ｨｬ0608ｨｺ0609ｨｹ, [46] Staphylococcus aureus, Clostridium spp. ｨｨ Bacillus subtilis, 26; ﾂ ﾂ55 08ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨｨｦ 08ｨ 09- [47] Lactobacillus genus, Candida ｨｨ ｨｰ090608, 09ｨｨｨｪ060008ｨ 01ｨｪ ｨｨｨｪ06, ｨ ｨｹ09ｨｨｨｪ060904ｨｦ 0906ｨｺ, ｨｰ06ｨｬｨ ｨｰｨｪｨ 07 07ｨ 09ｨｰｨ Pseudomonas fluo- 15; 30; 103; 483 ｪ ｨｺ06 [48] rescens, 35; 40 Alcaligenes Bacillus, Pseudomonas ｨｨ

5 1306ｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺ CO 2 [19, 20, 26, 27, 38, 39, 57, 58]. 06ｨ ｨｺ, ｨｪｨ 0708ｨｨｨｬ0208, 09 08ｨ ｨ 06ｨｰ02 [39] 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 06ｨ 08ｨ ｨ 06ｨｰｨｺｨ ｨｰ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｰｨｹ 01ｨ Aspergillus niger, ｨｺ06ｨｰ ｨｮ09ｨｰ06ｨｦ- ﾂｨｨ0904 ｨｺ 0108ｨｮ00ｨｨｨｬ ｨｬ02ｨｰ0601ｨ ｨｬ ｨｦ09ｨｰ09ｨｨ07. 06ｨ ｨｺ0302 ｨｨ ｨｰｨｪ06, ﾂｨｰ ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ 0902ｨｬ07ｨｪ ｨｦ ｨｪｨｨ0204 [52], 08ｨｨ ｨｰ08ｨｮｨ 02ｨｦ [59, 60] ｨｪｨｨ02 09ｨｰ0208ｨｨ05ｨｹｨｪ04 ｨｨ ｨｪ02 ｨｰ0802ｨ ｨｮ06ｨｰ ｨｪｨｨｨｰ0205ｨｹｨｪ06ｨｦ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ. 0201ｨｪｨ ｨｺ06 09ｨ 03ｨｪ ｨｬｨｪｨｨｨｰｨｹ, ﾂｨｰ06 05ｨｺ ｨｨｨｬ02ｨｪｨｰ ｨｨｨｪｨ ｨｺ ｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｺｨ 04ｨ 05ｨｨ: 0708ｨｨ080601ｨ 06ｨ 08ｨ ｨ ｨ ｨｰ0409ｨ 02ｨｬ06ｨｦ ｨｪ0609ｨｰｨｨ ｨｨ 05ｨｨ ｨｬ060302ｨｰ 06ｨｺｨ ｨ ｨｰｨｹ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ ｨｨ07ｨｪｨｨ02 ｨｪｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｦ09ｨｰ09 ｨｨ07 [61 ｪ64]. 08ｨｪｨ 05ｨｨ ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｪ ｨ ｨｪｨｪ ｨｺｨ ｨ 02ｨｰ, ﾂｨｰ ｨｰ06ｨｬ 01ｨ ｨｪｨｨ ｨｰ020702ｨｪｨｹ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ, ｨｺｨ ｨｺ 0708ｨ 09ｨｨ0506, ｨ 09ｨｰｨ 02ｨｰ [22, 25, 43, 52, 65]. 00 ｨｰ ｨｬ ｨ 09ｨｰ ｨｺｨ 04ｨ 05, ﾂｨｰ06 ｨ ｨｪｨ ｨｨ ﾂｨｪ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｮ ﾂ02ｨｪ04 ｨｨ ｨｮｨ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺ [38, 50, 52] ｨｬ02ｨｪ ﾂ0209ｨｨ01ｨｪ06, ﾂｨｰ ｨｪｨｨ02 ｨｰ02ｨｬ070208ｨ ｨｰｨｮ ｨ 0708ｨｨ ｨｰ ｨｺ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ [26, 27, 38] ｨ ｨｨｨｬ06 06 ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｮｨ -/ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨｨ01ｨ ｨｬｨｨ ｨｰ02ｨｺ ｨ 02ｨｰ ｨｪ0202, ﾂ02ｨｬ ｨｮ ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ, ｨｨ, 0706 ｨｬｨｪ02ｨｪｨｨ06 ｨｬｨｪ0600ｨｨ01 ｨ 09ｨｰ [20, 27, 38, 57], ｨｺｨｰｨｨ09ｨｪｨ 07 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ ｨｹｨｬｨ ｨｮ09ｨｰ06ｨｦ ﾂｨｨ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｰｨｨ00ｨｪｨｮｨｰｨ ｨｰ0605ｨｹｨｺ ｨｨ 0906 ﾂ02ｨｰｨ ｨｪｨｨｨｨ ｨｺ ｨ ｨｪｨｨ07 ｨｨ ｨｺ06ｨｦ ｨｰ02ｨｬ070208ｨ ｨｰｨｮ ｨｬ02 ｨｰ060006, ｨｬ0603ｨｪ ｨ ｨｰｨｹ , ﾂｨｰ06 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609, 0708ｨｨ09ｨｮｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ , ｨｮ ｨｨ07 ｨｨ 07ｨ 08ｨ ｨｬ02ｨｰ ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ ｨｪ0206ｨ ｨｨｨｬ ｨｰｨｹ ｨｺｨ ｨｺ06ｨｪｨｺ0802ｨｰｨｪ ｨｰ0201ｨｪ ｨｨ ﾂ0209ｨｺ ｨ ｨｨ07 ｨｨ 07ｨ 08ｨ ｨｬ02ｨｰ ｨ 00ｨｪ ﾂｨｨ090502ｨｪｨｪ0402 ｨｨ ｨ ｨｪｨｨ ｨｺｨ 04ｨ 05ｨｨ [64, 66 ｪ70], ﾂｨｰ06 01ｨ ｨｪｨｨ02, ｨｰ02ｨｬ070208ｨ ｨｰｨｮ08ｨ ｨｨ ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ ｨｰ0907 ｨ ｨ ｨｬｨｨ 07ｨ 08ｨ ｨｬ02ｨｰ08ｨ ｨｬｨｨ, ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ06ｨｴｨｨｨｬｨｨ 09ｨｰ020702ｨｪｨｹ ｨｨ09ｨ ｨｪｨｨ07 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ [26] Ballestra ｨｨ Cuq ｨｺ ｨ 04ｨ ｨｪ ｨｪｨｨ02, ﾂｨｰ ｨ 06ｨｴ ｨｨ07ｨｪｨｨ02 ｨｪｨ 09ｨｰ020702ｨｪｨｹ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02 ｨｨｨｨ 06ｨｺｨ ｨ 02ｨｰ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07 08ｨ 09ｨｰ ｨｪｨｪ (d ), 01ｨ ｨｨ 09ｨ ｨｬｨｨ ｨｺ0502ｨｰｨｺｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨ ｨｰ ｨｮ. 06ｨｰ ｨｪｨｨ ｨｹ ｨｪｨ 0708ｨｨｨｬ Geobacillus stearothermophilus, Bacillus subtilis, ｨ 09ｨｺ Bacillus fulva ｨｨ ｨｺ06ｨｪｨｨ01ｨｨｨｦ Aspergillus niger [71, 26, 37]. 0809ｨｰ ｨｰ ｨｪ ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07 08ｨ 09ｨｰ ｨｪｨｪ ｨｨ0702ｨｰ ｨｪｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｪｨ ｨｺ06 ｨｬｨ ｨｰ02ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｺ ｨｨｨｦ ｨｰ0806ｨｨｨｰｨｹ ｨｪ02 ｨｮ01ｨ ｨｹ, ｨｺ0605ｨｹｨｺｨｮ 04ｨ 09ｨｨ09ｨｨｨｬ06 09ｨｰｨｹ dco 2 06ｨｰ ｨｰ02ｨｬ070208ｨ ｨｰｨｮ0804 ｨｨ 01ｨ ｨｪｨｨ07 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｪ06ｨｦ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｨ09ｨ ｨｪｨｪ ｨｨ ｨ ｨｪｨｨｨｦ, ﾂ02ｨｰｨ ｨｪｨｨｨｨ 09 08ｨ ｨｪ ｨ ｨｪｨ 08ｨｮ0302ｨｪｨｪ04ｨｬ 00ｨ ｨｺｨｰ060806ｨｬ [20] ｨｬｨ ｨｺｨｰｨｨ09ｨｪ06ｨｦ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ 09ｨｮ01ｨｨ01 ｨｺ0502ｨｰ06ｨｺ E. coli, ｨｨ05ｨｨ ｨｨｨｰｨｹ, ﾂｨｰ ｨｺｨｰｨｨ09ｨｪ06ｨｦ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｪ0206ｨ ｨｨｨｬ ｨｨ09ｨｮｨｰ09ｨｰ09ｨｨ ｨｨ09ｨｰ02ｨｬ ｨｰ09ｨｨｨｨ ｨ ｨｮｨ 05ｨｨｨｺｨ 02ｨｨｨｦ ｨｰ ｨｨ 05ｨｨ ｨｹ ｨ 01 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609 (09ｨｬ., ｨｪｨ 0708ｨｨｨｬ0208, [22, 49, 72 ｪ 75]) ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｪ ｨｰｨ ｨｰｨｹ0701 ｨｨ 07ｨ ｨｰ02ｨｪｨｰｨ 01 [21, 50, 56, 72 ｪ 74, 76, 77] 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｨ ｨｹ040609ｨ ｨｪｨｨ ｨｬ060302ｨｰ 09ｨｰｨ ｨｰｨｹ ｨ ｨｺ06ｨｪ06ｨｬｨｨ ﾂｨｪ04ｨｬ ｨｬ 0708ｨｨ 0106ｨ ｨ ｨｪｨｨｨｨ ｨｪ02 ｨｰ0605ｨｹｨｺ , ｨｪ06 ｨｨ 05ｨｰｨ ｨｪ0605ｨ, ｨｬ02ｨｰｨ ｨｪ0605ｨ, ｨｺｨｨ09ｨｨ ｨ ｨｨ05ｨｨ 0108ｨｮ00ｨｨ ｨ ｨ 0906ｨｺ. Kamihira ｨ 09ｨｰ0608ｨ ｨｬｨｨ [20] 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ ｨｺｨｰｨｨ09ｨｪ06ｨｦ ｨｨｨｪｨ ｨｺｨｰｨｨ 09ｨ 02ｨｨｨｨ 09ｨｮ01ｨｨ01 ｨｺ06ｨｪｨｨ01ｨｨｨｦ 08. niger ｨｬ0600ｨｮｨｰ ｨ 04ｨｰｨｹ ｨｨ ｨｹ040609ｨ ｨｪ ｨ ｨ 09ｨｺｨｨ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0401 ｨｺ0605ｨｨ- ﾂ0209ｨｰ09 05ｨｰｨ ｨｪ0605ｨ ｨｨ05ｨｨ ｨｮｨｺ09ｨｮ09ｨｪ06ｨｦ ｨｺｨｨ090506ｨｰ ｨ ｨｨｨｬ06 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ ｨｺｨｨ09ｨｹ ｨ, 0106ｨ ｨ ｨｪｨｪｨ 07 01ｨ ｨ ｨｬ0401 ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0401 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07 01, ｨｺ ｨ 02ｨｰ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ [57, 67, 78 ｪ80] ｨ ｨｪｨｨ04ｨｬ04 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨ ｨｺ 09ｨｨ01ｨｪ06 ｨｨ ｨｰｨ ｨｪｨｪ ｨ ｨｪｨｪ0401, ｨ ｨｪｨｰｨｨｨｬｨｨｨｺ0806ｨ ｨｪ04ｨｦ ｨｺｨｰ 04ｨ 09ｨｨ09ｨｨｨｰ 06ｨｰ ｨｬｨｪ ｨｰ09ｨ 00ｨ ｨｺｨｰ , ｨｰｨ ｨｺｨｨ01 ｨｺｨ ｨｺ ｨｰ02ｨｬ070208ｨ ｨｰｨｮ08ｨ, 01ｨ ｨｪｨｨ02, ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 06ｨ 08ｨ ｨ 06ｨｰ- 7

6 ｨｮ , ｨｮ ｨ, ｨｦ, ｨ 0108ｨｨｨｪ, ｨｮ0804ｨｨｨｪ, ｨ ｨｪｨｨｨｺ0609ｨ, ｨｮｨｬ070609, ｨｬｨｨ0106ｨｪ0609ｨ ｨｺｨｨ ｨｨ ｨｪｨ 05ｨｨ ﾂｨｨ ｨ ｨ 0906ｨｺ, ｨ ｨｰｨ ｨｺ ｨｰ 09ｨｨ01ｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬｨ ｨｨ , ﾂｨｰ06 ｨｮ ｨ ｨｬ ｨ ｨｰ ｨｨｨｰｨｹ ﾂ ﾂｨ ｨｦｨｪ ｨｪ04ｨｦ ｨｬ0201ｨ ｨｪｨｨ 04ｨｬ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｦ09ｨｰ09ｨｨｨｰ0205ｨｹｨｪ06, ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ ｨｬｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｺ ｨｨｨｬ 02ｨｪｨｰｨ 05ｨｹｨｪ ｨ ｨｪｨｪ0401, ｨｨ ｨｪ ｨｬｨｨ080609ｨ ｨｪ 0201ｨｨｨｪ04ｨｦ ｨｪｨ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ ｨ ｨｪｨｰｨｨｨｬｨｨｨｺ0806ｨ ｨｪ ｨｦ09ｨｰ09ｨｨ07 CO ｨｨ ｨ ｨｪｨｨｨｦ 00ｨｨｨ 0205ｨｹ ｨｺ0502ｨｰ06ｨｺ 06ｨ ｨｲ0709ｨｪ0705ｨ 09ｨｹ 08ｨ 0405ｨｨ ﾂｨｪ04ｨｬｨｨ 0708ｨｨ ﾂｨｨｨｪｨ ｨｬｨｨ: ｨｺ 0708ｨｨｨｬ0208ｨｮ, 04ｨ ｨｺｨｨ090502ｨｪｨｨ02ｨｬ (ｨ 02ｨｨ01ｨｨ00ｨｨｨｺｨ 02ｨｨ02ｨｦ) 08ｨ 09ｨｰ ｨｪｨｪ04ｨｬ CO 2, 0708ｨｨ ｨｴｨｨｨｬ ｨｺ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｺ0506 ﾂ ｨｬ02ｨｪｨｰ0609, ｨｴｨｨ ｨ 03ｨｪ02ｨｦ 03ｨｨ01 ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ [7, 8, 10, 35, 81, 82], ｨｨ 05ｨｺ09ｨｰ08ｨ ｨｺ02ｨｨ02ｨｦ 09ｨｪｨｮｨｰ08ｨｨｨｺ0502ｨｰ06 ﾂｨｪ ｨｮｨ 09ｨｰｨ ｨｪ02ｨｨｨｦ, ｨｰｨ ｨｺｨｨ01 ｨｺｨ ｨｺ 00ｨｨ ｨ ｨｪ ｨｨｨｪ02ｨｪｨｨ07 09 ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 09ｨｰ02ｨｪｨｺ02 ｨｨ 02ｨｨｨｰ ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ02, 0708ｨｨ ｨｴ02ｨｦ ｨｺ 00ｨｨｨ 0205ｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬｨ [20]. 04ｨ ｨｺ 0502ｨｰ06 ﾂｨｪ06ｨｦ 06ｨ ﾂｨｺｨｨ 0708ｨｨ ｨｪｨｨｨｺｨｪ060902ｨｪｨｨｨｨ CO 2 09ｨｪｨｮｨｰ08ｨｹ ｨｺ0502ｨｰｨｺｨｨ ｨｬ0600ｨｮｨｰ ｨｮｨｬ02ｨｪｨｹ03ｨ ｨｰｨｹ ｨｨ09ｨ 02ｨｬ0609ｨｰｨｹ [21, 22], ｨ ｨｪｨｨ02 ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ ｨｨ ｨｪｨ ｨ ｨｮ01ｨ ｨｪｨｨｨｨ ｨｦ09ｨｰ09ｨｨ02ｨｬ 0903ｨ ｨｰ CO 2 ｨｬ060302ｨｰ ｨｮｨ ｨｨ09ｨ ｨｰｨｹ ｨｺ0502ｨｰｨｺｨｨ ｨｨ05ｨｨ ｨ ｨｰｨｹ ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ02 ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ01 09ｨｨ09ｨｰ02ｨｬ [37, 71, 78] ｨ ｨｪｨｨ ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｦ09ｨｰ09ｨｨ 07 06ｨｺｨ ｨ 02ｨｰ ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ ｨｨ 0105ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 06ｨ 08ｨ ｨ 06ｨｰｨｺ ｨｺｨｨｨｬ 01ｨ ｨｪｨｨ02ｨｬ CO 2 ｨｨ ｨ 0409ｨｰ0806ｨｦ 0102ｨｺ06ｨｬ ｨｨｨｨ, ﾂ02ｨｬ 0708ｨｨ 02ｨｨｨｺ05ｨｨ ﾂ0209ｨｺ06ｨｦ 06ｨ 08ｨ ｨ 06ｨｰｨｺ02 ｨｨ ｨｬ ｨｪｨｪ06ｨｦ 01 02ｨｺ06ｨｬ ｨｨｨｨ [21]. 0308ｨｨ 0105ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 06ｨ 08ｨ ｨ 06ｨｰｨｺ ｨｰ ｨｨ ﾂｨｨｨｪ04 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｬ0600 ｨ 04ｨｰｨｹ ｨ ｨｪ ｨｬ ｨｬ02ｨｬｨ 08ｨ ｨｪ ｨｨ ｨｺ06ｨｬ ｨｪｨｨｨｺｨｪ060902ｨｪｨｨｨｨ 09 ｨｺ0502ｨｰｨｺｨｨ 0903ｨ ｨｰ CO 2. Debs-Louka ｨｨ 0906ｨｰ08ｨｮ01ｨｪｨｨｨｺｨｨ [22] ｨｪ02 ｨｪｨ ｨ ｨ 05ｨｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ ｨｨ07ｨｪｨｨ07 09ｨｺ ｨｰｨｨ 0102ｨｺ06ｨｬ ｨｨｨｨ ｨｪｨ ｨｺ0605ｨｨ- ﾂ0209ｨｰ ｨｨ0903ｨｨ01 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｮｨ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 06 ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ ｨｺ0502ｨｰ06ｨｺ CO ｨｨ ｨｰ ｨ 0405ｨｨ ﾂｨｪ ｨｬ02ｨｪｨ ｨｺ06ｨｬ ｨｨｨｨ (0,4 09, 15 ｨｬｨｨｨｪ, 50 ｨｬｨｨｨｪ) ｨｰ ｨｮ00ｨｨ01 08ｨ ｨ 06ｨｰ [27, 50, 51] 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 05ｨｰｨ 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｹ 09ｨｮｨｴ0209ｨｰ09ｨｮ02ｨｰ ( ﾂ02ｨｬ ｨｬ02 ｨｪｨｹ ｨｬ ｨｺ06ｨｬ ｨｨｨｨ, ｨｰ02ｨｬ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07) ｨｬ0603ｨｪ06, 0708ｨｨ ｨ 0409ｨｰ0806ｨｦ 0102ｨｺ06ｨｬ ｨｨｨｨ 08ｨ ｨｰ08ｨ ｨｪ02ｨｪｨｨ ｨｪｨｮｨｰ08ｨｨ ｨｺ0502ｨｰｨｺｨｨ ｨｬ ｨｨ090209ｨｰｨｨ ｨｺ 08ｨ 0408ｨｮ0302ｨｪｨｨ ｨｪ02ｨｦ. 0201ｨｪｨ ｨｺ06 01ｨ ｨｪｨｪ ｨｪｨｨ02 06 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ02 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｰ0802ｨ ｨｮ 02ｨｰ ｨｺｨｨ ｨ ｨｲ0709ｨｪ02ｨｪｨｨ ｨｦ09ｨｰ09ｨｨ ｨ ｨｰ CO ｨ ｨ 06ｨｰ [51, 71] ｨｨ ｨｹ040609ｨ 05ｨｨ 0601ｨｪ06ｨｮ01ｨ 08ｨｪ04ｨｦ 01ｨ 08ｨ ｨｺｨｰ ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ ｨｺ08ｨｨ0906ｨｦ ｨｨ09ｨ 02ｨｬ0609ｨｰｨｨ ｨｺ 0502ｨｰ06ｨｺ (04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｹ ｨ 08ｨｨ00ｨｬｨ ﾂｨｨ0905ｨ ｨｨ0903ｨｨ01 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｰ ｨｬ02ｨｪｨｨ, ｨｰ02ｨｬ ｨ ｨｰｨｮ0804 ｨｨ05ｨｨ 01ｨ ｨｪｨｨ07). 0201ｨｪｨ ｨｺ06 ｨｰｨ ｨｺｨ ｨｪ06ｨｮ01ｨ 08ｨｪｨ 07 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｹ ｨｨ ｨ 02ｨｰ 05ｨｨ03ｨｹ 00ｨ 04ｨｮ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 00ｨｨｨ 0205ｨｨ ｨｪｨ ｨｪ02ｨｦ ﾂｨ 09ｨｰｨｨ ｨｺ08ｨｨ0906ｨｦ. 06ｨｰ06 06ｨ ｨｲ0709ｨｪ0702ｨｰ 0907 ｨｰ02ｨｬ, ﾂｨｰ06 09ｨｪｨ ﾂｨ 05ｨ 0508-CO 2 08ｨ 09ｨｰ ｨｰ ｨｮ090702ｨｪ04ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ ｨｨ 05ｨｨ03ｨｹ 04ｨ ｨｰ02ｨｬ ｨｪｨｨｨｺｨ 02ｨｰ ﾂ ｨｺ0502ｨｰ06 ﾂｨｪｨｮ06 ｨｬ02ｨｬｨ 08ｨ ｨｪｨｮ ｨｰ ﾂｨｰ06ｨ 04 ｨ ﾂ02ｨｰｨｺ ｨｰｨ 09ｨｨｨｰｨｹ 04ｨ 09ｨｨ 09ｨｨｨｬ0609ｨｰｨｹ ｨｺｨｨｨｪ02ｨｰｨｨｨｺｨｨ 00ｨｨｨ 0205ｨｨ ｨｺ0502ｨｰ06ｨｺ ｨ 05ｨｹｨｪ06ｨｦ 09ｨｨｨｰｨｮｨ 02ｨｨｨｨ, ｨｬｨ ｨｰ02ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨ02 ｨｬ ｨｨ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ 0508-CO ｨｪ04 ｨｮ ﾂｨｨｨｰ0409ｨ ｨｰｨｹ 06ｨ 02 09ｨｰｨ 01ｨｨｨｨ. 08ｨ ｨｺ ｨ ｨｴｨ ｨｹ 09 [18, 34, 35, 81, 82], ｨｪｨ ｨｺ08ｨｨ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｪｨ ｨ ｨ 05ｨｨ09ｨｹ ﾂ02ｨｰｨｺｨｨ02 00ｨ ｨ 04ｨｪ04ｨｬｨｨ 09ｨｺ ｨｰ07ｨｬｨｨ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｰｨ ｨｬｨｬ0609 E. 09oli, ｨｺ06ｨｰ ｨ 08ｨ ｨ ｨ ｨｰ0409ｨ 05ｨｨ09ｨｹ 0508-CO 2. 06ｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｺ0502ｨｰ06ｨｺ E. coli ｨｬ ｨｪｨｪ ｨ ｨｪｨ ｨｪｨ ﾂｨ 05ｨｹｨｪ06ｨｦ 09ｨｰｨ 01ｨｨｨｨ (00ｨ 04ｨ ｨｪｨ ｨｺ ｨｪｨｨ07), ｨ 04ｨ ｨｰ02ｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｨ04ｨｪ ｨ ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 09ｨｰ0802ｨｬｨｨｨｰ0205ｨｹｨｪ06 07ｨ 01ｨ 0506 (00 ｨ 04ｨ 00ｨｨｨ 0205ｨｨ) ｨｨｨｰ0208ｨ ｨｰｨｮ ｨｪ06 ｨｪ0209ｨｺ0605ｨｹｨｺ06 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609, ｨ ｨｪｨｪ ｨ ｨｪｨｨ02ｨｬ ｨｺ0502ｨｰ06 ﾂｨｪ ｨｪｨｨ07 05ｨｺ09ｨｰ08ｨ ｨｺ02ｨｨ02ｨｦ ｨｨ 06ｨｺｨｨ090502ｨｪｨｨ02ｨｬ. 0201ｨｪｨ ｨｨ ｨｨ0706ｨｰ0204, 06ｨ ｨｲ0709ｨｪ0706ｨｴｨ 07 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ06ｨｴ ｨｦ09ｨｰ09ｨｨ , ｨｰｨ ｨ 0906ｨ 06ｨｦ ｨｰ020608ｨｨ ｨ ｨｪｨｨ07, ｨ 09ｨｪ06 ｨｺ06ｨｰ060806ｨｦ ｨ 0201ｨｪ0702ｨｰ ｨｺ0502ｨｰｨｺｨｨ ｨｺｨｨ ｨｬ. 0201ｨｪｨ ｨｺ06 05ｨｰ06ｨｰ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ ｨ ｨｪ ｨｪｨｮｨｰ, ｨｺ060001ｨ ｨ ｨ ｨｪｨ 08ｨｮ0302ｨｪ06, ﾂｨｰ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｰ ｨｰｨ ｨｺ0302 ｨ ｨｪｨ ｨ ｨｪ0402 ｨ ｨ ｨｺｨｰ0208ｨｨｨｨ [14] ｨ 09ｨｪ06 ｨｬ0201ｨ ｨｪｨｨ04ｨｬｨｮ 05ｨｺ09ｨｰ08ｨ ｨｺ02ｨｨｨｨ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ ｨｬ06ｨｴｨｹ ｨｮｨｴ0209ｨｰ ｨｰ ｨ 09 ﾂ02ｨｰ ｨｪｨｨｨｺｨｪ060902ｨｪｨｨ07 09ｨｺ090604ｨｹ ｨｺ0502ｨｰ06 ﾂｨｪｨｮ06 ｨｬ02ｨｬｨ 08ｨ ｨｪｨｮ, 08 ｨ 09ｨｰ ｨｪｨｨ07 09 ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 03ｨｨ01ｨｺ0609ｨｰｨｨ ｨｨ 04ｨ ｨｰ02ｨｬ 05ｨｺ09ｨｰ08ｨ 00ｨｨ080609ｨ ｨｪｨｨ07 09ｨｪｨｮｨｰ08ｨｨｨｺ0502ｨｰ06 ﾂｨｪ ｨｨｨｬ Park 09 ｨｺ ｨ ｨｬｨｨ [41] ｨｨ04ｨｬ ｨｨ ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｺ09ｨｰ08ｨ 00ｨｨ08ｨｮ02ｨｬ ｨｪｨｮｨｰ08ｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ ｨｬｨ ｨｰ0208ｨｨｨ 05ｨ 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ ｨｰｨ 01ｨ ｨｪｨｨ07 ｨｨ 06ｨ ｨｪｨ 08ｨｮ03ｨｨ05ｨｨ ｨｪｨ 05ｨｨ ﾂｨｨ ｨｪｨｨｨｦ ｨｬ02ｨｬｨ - 8

7 1306ｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺ CO 2 08ｨ ｨｪ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ. Enomoto 09 ｨｺ ｨ ｨｬｨｨ [19], 0908ｨ 09ｨｪｨｨ09ｨ 07 ｨｬ ｨｪｨｪｨｮ06 ｨｨ ｨ 0409ｨｰ08ｨｮ ｨｺ06ｨｬ ｨｨ06, 06ｨ ｨｪｨ 08ｨｮ03ｨｨ05ｨｨ ｨ 0605ｨｹ ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｰ02ｨｨｨｪ0609, ｨｨ01 ｨｨ04 ｨｺ0502ｨｰ06ｨｺ 0708ｨｨ ｨ 0409ｨｰ0806ｨｬ ｨ ｨｪｨｨｨｨ 06ｨｰ , 0601ｨｪｨ ｨｺ ﾂ05ｨｨ, ﾂｨｰ06 09ｨｺ ｨｰｨｹ 0102ｨｺ06ｨｬ ｨｨｨｨ ｨｪ ｨｨ0702ｨｰ ｨｪｨ ｨｨ09ｨ 02ｨｬ0609ｨｰｨｹ ｨｺ0502ｨｰ06ｨｺ. 06ｨｰ ｨ 00ｨ 02 ｨｰ, ﾂｨｰ06 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ ｨｰｨｨ00ｨ 02ｨｰ0907 ｨｪｨ 05ｨｰｨ ｨｰｨ 01ｨ ｨｪｨｨ ｨｨ07 04ｨ ｨｺｨｨ090502ｨｪｨｨ07 (ｨ 02ｨｨ01ｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ) ｨ 00ｨ 02ｨｰ, ﾂｨｰ ｨ 00ｨｨ08ｨｮ02ｨｰ ｨｦ 09 06ｨ 08ｨ ｨ ｨｪｨｨ02ｨｬ ｨｮ000605ｨｹｨｪ06ｨｦ ｨｺｨｨ090506ｨｰ04 ｨｨ ｨｮｨｬ02ｨｪｨｹ03ｨ 02ｨｰ 0801 ｨｺｨ ｨｺ 09 06ｨｺ08ｨｮ 03ｨ 06ｨｴ02ｨｦ , ｨｰｨ ｨｺ ｨｨ 09ｨｪｨｮｨｰ08ｨｨ ｨｺ0502ｨｰ06ｨｺ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609 [18]. 02ｨ ｨｪｨｪｨ 07 ｨｰ020608ｨｨ ｨｮ ﾂｨｨ05ｨ ｨｰ ｨｪｨｨ ｨｨ ｨｨ ｨ ｨｪｨｨｨｨ ｨｨ 09ｨｮ01ｨｨ01 ｨｺ0502ｨｰ06ｨｺ [21, 72]. 0201ｨｪｨ ｨｺ06 09ｨｮｨｴ0209ｨｰ09ｨｮ 06ｨｰ ｨｨ ｨ ｨｪｨｨ07, ｨｺ06ｨｰ ｨｺｨ ｨ 06ｨｰ, ﾂｨｰ ｨｦ09ｨｰ09ｨｮ02ｨｰ ｨｨ ｨｪｨ ｨｪ02 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0402 ｨｺ ｨｺｨｨ090506ｨｰ02 ｨ ｨ ｨｺｨｰ0208ｨｨｨｨ, ｨｰｨ ｨｺｨｨ02 ｨｺｨ ｨｺ Listeria [24, 25]. 0102ｨｺ06ｨｰ ｨ ｨｪｨｪ ｨｺｨ ｨ 06ｨｰ, ﾂｨｰ ｨｨ 05ｨｰ06ｨｬ ｨｪ ｨｰｨｨ00ｨ 06ｨｰ ｨｰｨ ｨｰ06 ﾂｨｪ06 ｨｪｨｨ04ｨｺｨｨ02 04ｨｪｨ ﾂ02ｨｪｨｨ , ｨｺ06 ｨｰ ｨｺｨｰｨｨ09ｨｪ06 ｨｮｨ ｨｨ09ｨ 06ｨｰ ｨ ｨ ｨｺｨｰ0208ｨｨｨｨ, ｨ 09ｨ 0302ｨｪ ｨｰｨｨ07 ｨｺｨｨ090506ｨｰ04 [14, 83]. 00 [83] ｨｨ ｨ 05ｨｨ ｨｨ04 ｨｬ02ｨｪ02ｨｪｨｨ ｨ ｨｮ000208ｨ 09 07ｨ 0506 ﾂｨｪ06ｨｬ 0906ｨｺ02 07ｨｮｨｰ02ｨｬ 0106ｨ ｨ ｨｪｨｨ ｨｨ05ｨｨ ｨｮ000605ｨｹｨｪ06ｨｦ ｨｺｨｨ090506ｨｰ04 ｨｨ 06ｨ ｨｪｨ 08ｨｮ03ｨｨ05ｨｨ, ﾂｨｰ06 ｨｺｨｨ090506ｨｰｨ ｨ ｨｺｨｰｨｨ09ｨｪｨ, ﾂ02ｨｬ Daniels 09 ｨｺ ｨ ｨｬｨｨ [14] 0708ｨｨ0305ｨｨ ｨｺ 04ｨ ｨｺ0506 ﾂ02ｨｪｨｨ06, ﾂｨｰ06 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｪ02 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｮ05ｨｹｨｰｨ ｨｰ06ｨｬ ｨｰ0605ｨｹｨｺ06 04ｨ ｨｺｨｨ090502ｨｪｨｨ ｨｨ ﾂ02ｨｪｨｨ02 ｨｺｨｨ090506ｨｰｨｪ0609ｨｰｨｨ ｨｬ060302ｨｰ 05ｨｨ03ｨｹ 0706ｨｬ06 ﾂｨｹ ｨｰｨｮ ｨｺ0502ｨｰ06 ﾂｨｪ06 ｨｦ ｨｪｨｨ02ｨ 02ｨｬ0609ｨｰｨｨ, ﾂｨｰ06 06ｨ ﾂｨｨｨｰ ｨｪｨｨｨｺｨｪ060902ｨｪｨｨ ｨｨ01ｨ 09ｨｪｨｮｨｰ08ｨｹ ｨｺ0502ｨｰｨｺｨｨ [84]. 08ｨ ｨｺ ｨ 00ｨ 06ｨｰ Haas ｨｨ 0906ｨｰ08ｨｮ01ｨｪｨｨｨｺｨｨ [70], 05ｨｰ06 07ｨ 0102ｨｪｨｨ02 ph ｨ ｨｮ0102ｨｰ ｨｪ0206ｨ 08ｨ ｨｰｨｨｨｬ06 ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｰ ｨｹ 09ｨ 03ｨｪ02ｨｦ03ｨｨ02 ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ02 09ｨｨ09ｨｰ02ｨｬ ｨ 09ｨｪ06 ｨ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨ ｨｪｨｰｨｨｨｬｨｨ ｨｺ0806ｨ ｨｪ04ｨｦ ｨｺｨｰ ｨ ｨｪ ｨｪ ｨ ｨｪｨｨ02ｨｬ CO 2, ｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ02ｨｦ ｨｪｨｮｨｰ0802ｨｪｨｪ02ｨｦ ｨｺ0502ｨｰｨｺｨｨ ｪ 09 dco 2 [71]. 06ｨｺ ｨｨｨｬ02ｨｪｨｰ ｨｨ05ｨｨ09ｨｹ 09 ｨｪｨ 0904ｨｴｨ 06ｨｴｨｨｨｬｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07ｨｬｨｨ CO ｨｨ 08ｨ 0405ｨｨ ﾂｨｪ0401 ｨｺ06ｨｬｨ ｨｨｨｪｨ 02ｨｨ ｨ ｨｪｨｨ07 ｨｨ ｨｰ02ｨｬ070208ｨ ｨｰｨｮ0804. Shimoda ｨ 09ｨｰ0608ｨ ｨｬｨｨ [39] 04ｨ ｨｺ0506 ﾂｨ 06ｨｰ, ﾂｨｰ06 05ｨｨ03ｨｹ ｨｺ06ｨｬｨ ｨｨｨｪｨ 02ｨｨ07 08ｨ 0405ｨｨ ﾂｨｪ0401 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ ｨｨ090601ｨｨｨｰ ｨｺ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ ｨｺｨ 04ｨ ｨｪｨｪ ｨｬ0603ｨｪ ｨ ｨｰｨｹ , ﾂｨｰ06 ｨｰ0802ｨ ｨｮ06ｨｰ ｨ 05ｨｹｨｪ02ｨｦ03ｨｨ02 ｨｨ ｨ ｨｪｨｨ07 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02 ｨｨｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨ ｨｪｨｨ02ｨｬ ﾁ ｨ ｨｺ0506 ﾂ02ｨｪｨｨ ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ06 01ｨｨ06ｨｺ09ｨｨ01 ｨｮ ｨ 0708ｨｨ ｨｮ ｨｬ020802ｨｪｨｪ ｨ ｨｪｨｨ0701 ( ｨ ｨｰｨｬ) ｨｨ ｨｰ02ｨｬ070208ｨ ｨｰｨｮ08ｨ 01 ( 縺05) ｨ 02ｨｪ ｨｺｨｰｨｨ09ｨｪ06 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｰｨｹ ｨｬｨｪ0600ｨｨ02 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｪ ｨ 09ｨｰ090608ｨ ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ07 ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ0402 ｨｨ ｨ ｨｪｨｨ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬｨ ｨｬｨｨ ｨｮｨｰ ｨｬｨｪ0600ｨｨ01 09ｨｰ08ｨ ｨｪｨ 01 ｨｬｨｨ08ｨ (06ｨｰｨ 05ｨｨ07, ｨ ｨｪｨｨ07, ｨｹ00ｨｨ07, ｨｪｨｨ07, , 06ｨ ｨｦ09ｨ ｨｪｨｹ, 06ｨｮ0802ｨｨ07, ｨｨ 0108.) ｨ ｨ 06ｨｰｨ 01 ｨｬｨｪ0600ｨｨ01 ｨｨ ｨ ｨｰ020502ｨｦ 0706ｨｺｨ 04ｨ ｨｪｨ ｨｺｨｰｨｨ09ｨｪ06 09ｨｰｨｹ ｨｨ ｨｬ0603ｨｪ0609ｨｰｨｹ ｨｨ ｨｹ040609ｨ ｨｪｨｨ07 05ｨｰ ｨｬ02ｨｰ0601ｨ 09 07ｨｨｨｴ020906ｨｦ ｨｨ 00ｨ 08ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｬ ｨｪｨｪ0609ｨｰ0701 ｨｺｨ ｨｺ ｨ 05ｨｹｨｰ0208ｨｪｨ ｨｰｨｨ09ｨｪ ｨｰ08ｨ 01ｨｨ02ｨｨ06ｨｪｨｪ04ｨｬ ｨｬ02ｨｰ0601ｨ ｨｬ 09ｨｰ0208ｨｨ05ｨｨ04ｨ 02ｨｨｨｨ/ 07ｨ 09ｨｰ0208ｨｨ04ｨ 02ｨｨｨｨ. 0608ｨｮ01ｨｪ ｨｪｨｨｨｰｨｹ 04ｨｪｨ ﾂ02ｨｪｨｨ ｨｬ0603ｨｪ0609ｨｰｨｨ ｨｨ ｨｰ09ｨ ｨ ｨ 09ｨｪ ｨｮｨｺｨｰ ｨｨｨｰｨ ｨｪｨｨ07 ｨｨ ｨｪｨ 07ｨｨｨｰｨｺ0609 ｨ ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 ｨｰ0208ｨｬ0606ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ. 0201ｨｪｨ ｨｺ06 ｨｪｨ ｨｨｨ 0605ｨｹ ｨ ｨｰ08ｨ ｨｪ02ｨｪｨｨ02 01ｨ ｨｪｨｪｨ 07 ｨｰ0201ｨｪ ｨｨ ｨｮ ﾂｨｨｨｰ 05ｨｨ03ｨｹ ｨｰｨｨ0302ｨｪ ｨｨ ｨｪ ｨｪｨｨｨｬｨ ｨｪｨｨ07 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｦ09ｨｰ09ｨｨ 02ｨｬ 0903ｨ ｨｰ ｨ 0909ｨｬ06ｨｰ0802ｨｪｨｪ ｨｨｨｰ0208ｨ ｨｰｨｮ08ｨｪ ｨ ｨｪｨｪ ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 08ｨ ｨ 06ｨｰ ｨ 05ｨ 09ｨｰｨｨ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ ｨｨ01ｨｺ ｨｨ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺ ｨｰ ｨｰ ｨｪ0609ｨｪ0401 ｨｪｨ 0708ｨ ｨｪｨｨ0701: ｪ ｨｨ ｨ ｨｪｨｨ02 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609; ｪ ｨｨ ｨ ｨｪｨｨ07 06ｨ ｨ 08ｨ 03ｨｨ09ｨ ｨｪｨｨ07 08ｨ 0405ｨｨ ﾂｨｪ ｨｮｨｺｨｰ0609 ｨｨ ｨｬｨ ｨｰ0208ｨｨｨ ; ｪ 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨ ｨｬ02ｨｰ ｨｨ 06ｨ 0608ｨｮ010609ｨ ｨｪｨｨ ｨｬ ｨｪｨｪ ｨｨ ｨｹ040609ｨ ｨｪｨｨ07 09ｨｰ0208ｨｨ05ｨｨ04ｨ 02ｨｨｨｨ ｨｨ06ｨｺ09ｨｨ01ｨ ｨｮ ｨ. 9

8 ｨｮ , ｨｮ ｨ, ｨｦ, ｨ 0108ｨｨｨｪ, ｨｮ0804ｨｨｨｪ, ｨ ｨｪｨｨｨｺ0609ｨ, ｨｮｨｬ070609, ｨｬｨｨ0106ｨｪ0609ｨ 01ｨ ｨｪ07 ｨｬ0603ｨｪ06 ｨｮｨｰ ｨ ｨｰｨｹ, ﾂｨｰ06 ｨｪｨｨ04ｨｺ06ｨｰ02ｨｬ070208ｨ ｨｰｨｮ08ｨｪｨ 07 09ｨｰ0208 ｨｨ05ｨｨ04ｨ 02ｨｨ07 03ｨｨ01ｨｺｨｨ01 07ｨｨｨｴ ｨｮｨｺｨｰ0609 ｨｪ02 ｨｰ0605ｨｹｨｺ06 06ｨ ﾂｨｨ09ｨ 02ｨｰ ｨ ｨ 09ｨｪ ｨ ｨｪ02ｨｪｨｨ02 ｨｨ ｨｨ ｨｹ040609ｨ ｨｪｨｨ ｨｮｨｺｨｰ0609, ｨｪ06 ｨｨ ｨｪ02 ｨｨ04ｨｬ02ｨｪ0702ｨｰ ｨｨ01 ｨｺｨ ﾂ0209ｨｰ09ｨ ｨｪ ｨ ｨ 09ｨｨｨｰｨｹ, ﾂｨｰ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｦ09ｨｰ09ｨｨ ｨｪｨ ｨｨｨ ｨｺｨ ｨｮｨｺｨｰ0609, ｨ ｨｴｨｨ01 05ｨｨｨ ｨｨ080601ｨｪ0402 ｨｺｨｨ090506ｨｰ04 (ｨ ｨｹ09ｨｨｨｪ060904ｨｦ, 07ｨ 0506 ﾂｨｪ04ｨｦ ｨｨ 0108ｨｮ00ｨｨ ｨｺｨｨ), 05ｨｨｨ 06 05ｨｰｨｨ ｨｦ 0907ｨｨ08ｨｰ (09ｨｨｨｪ06, 07ｨｨ0906, ｨｺｨｮｨｬ0409). 00ｨｪ0600ｨｨ02 05ｨｺ ｨｰ04 [85 ｪ88] ｨ 00ｨ 06ｨｰ, ﾂｨｰ ｨｬ ｨｪｨｪ ｨｨ ｨｹ040609ｨ ｨｪｨｨ07 ｨｰｨ ｨｺ06ｨｦ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ ｨｮ02ｨｰ 0603ｨｨ01ｨ ｨｰｨｹ 09 ｨ 05ｨｨ03ｨ ｨｦ ｨｬ Donald J.R., Jones C.L., MacLean A.R.M. Am. J. Public Health Vol. 14. P Russell A.D. Principles of antimicrobial activity, in Disinfection, sterilization, and preservation / Ed. by S.S. Block. London: Lea, P Juneja V.K., Thayer D.W. Irradiation and other physically based control strategies for foodborne pathogens in Microbial Food Contamination / Ed. by C.L. Wilson, S. Droby. CRC, Boca Raton, P. FL Tholozan T.J.L., Ritz M., Jugiau F., Federighi M., Tissier J.P. J. Appl. Microbiol Vol. 88. P Tahiri I., Makhlouf J., Paquin P., Fliss I. Food Res. Int Vol. 39. P Knorr D., Heinz V. Development of nonthermal methods for microbial control, in Disinfection, sterilization, and preservation / Ed. by S.S. Block. London: Lea, P Sonoike K. J. Jpn. Soc. Food Sci. Technol Vol. 44. P Walker H.W., LaGrange W.S. Sanitation in food manufacturing operations, in Disinfection, sterilization, and preservation / Ed. by S.S. Block. London: Lea, P Block S.S. Definition of terms, in Disinfection, sterilization, and preservation / Ed. by S.S. Block. London: Lea, P Joslyn L.J. Sterilization by heat, in Disinfection, sterilization, and preservation / Ed. by S.S. Block. London: Lea, P Perrut M. Sterilization and virus inactivation by Supercritical Fluids: A review, Separex, Champigneulles. Proc. (M) 3 rd International Symposium on Supercritical Fluids. Strasbourg (France), October Spilimbergo S., Bertucco A. Biothech. Bioeng Vol. 84. No. 6. P Koutchma T., Murakami E. Effect of Carbon Dioxide and Pressure Processing on Microbial and Enzyme Inactivation in Food and Beverages. effectofcarbondioxide.htm 14. Daniels J., Krishnamurthi R., Rizvi S. J. Food Protec Vol. 48. P Isenschmid A., Marison I.W., von Stockar U. J. of Biotechnology Vol. 39. P Spilimbergo S., Dehghani F., Bertucco A., Foster N.R. Biotechnol Bioeng. Apr Vol. 82. P Tomasula P.M. Supercritical fluid extraction of food // Encyclopedia of Agricultural, Food, and Biological Engineering / Ed. by D. Heldman. New York: Dekker, Ballestra P., Da Silva A.A., Cuq J.L. J. Food Sci Vol. 61. P Enomoto A., Nakamura K., Nagai K., Hashimoto T., Hakoda M. Biosci. Biotech. Biochem Vol. 61. No. 7. P Kamihira M., Taniguchi M., Kobayashi T. Agric. Biol. Chem Vol. 51. P Shimoda M., Yamamoto Y., Cocunubo-Castellanos J., Tonoike H., Kawano T., Ishikawa H., Osajima Y. J. Food Sci Vol. 63. P Debs-Louka E., Louka N., Abraham G., Chabot V., Allaf K. Appl. Envir. Microbiol Vol. 65. P Jones R., Greenfield P. Enzyme Microb. Technol Vol. 4. P Corwin H., Shellhammer T.H. J. Food Sci Vol. 67. No. 2. P Murakami E., Reddy N.R., Larkin J.W., Sizer C.E., Meneghel R., Ting E.Y., Takeuchi K., Chirtel S.J. Proc. Inst. of Food Technol. Ann. Meet. Las Vegas, July 12 ｪ16, P Ballestra P., Cuq J.L. Leben.-Wissen. Technol Vol. 31. P Watanabe T., Furukawa S., Hirata J., Koyama T., Ogihara H. Appl. Envir. Microbiol Vol.69. No. 12. P

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10 ｨｮ , ｨｮ ｨ, ｨｦ, ｨ 0108ｨｨｨｪ, ｨｮ0804ｨｨｨｪ, ｨ ｨｪｨｨｨｺ0609ｨ, ｨｮｨｬ070609, ｨｬｨｨ0106ｨｪ0609ｨ 70. Haas G.J., Prescott H.E., Dudley E., Dick R., Hintlian C., Keane L. J. Food Safety Vol. 9. P Shimoda M., Cocunubo-Castellanos J., Kago H., Miyake M., Osajima Y., Hayakawa I. J.Appl. Microbiol Vol. 91. P Kumagai H., Hata C., Nakamura K. Biosci. Biotech. Biochem Vol. 61. No. 6. P Perrut M. High Pres. Biotechnol Vol P Motta-Meira M., Arul J., Thibault J., Lavoie M. Proc. V Symp. High Pres. Food Sci. La Grande Motte (France), Venturi A., Dellaglio F., Dallacasa V., Pallado P., Bertucco A. Proc. V Conf. Supercrit. Fluids. Garda (Italy), P Kim S.R., Rhee M.S., Kim B.C., Kim K.H. Int. J. Food Microbiol Vol No. 1. P Clifford J.R., Williams A.A. Supercritical Fluid Methods and Protocols Human Press. Totowa, New Jersey, Hong S.-I., Pyun Y.-R. J. Food Sci Vol. 64. P Hemmer J.D., Drews M.J., LaBerge M., Matthews M.A. J. Biomed. Mat. Res. Appl. Biomat Vol. 80B. No. 2. P Zhang J., Sarah B., Courtney G., Michael M., Michael D., Laberge M. J. Microbiol. Methods Vol. 66. No. 3. P Hong S.I., Park W.S., Pyun Y.R. LWT-Food Sci. Technol Vol. 30. P Erkman O. Food Microbiol Vol. 17. P Bang W. Combined effects of CO 2, ph and high hydrostatic pressure on inactivation of Saccharomyces cerevisiae and Escherichia coli in apple juice. Masters Thesis, Washington State Univ., Lin Ho-mu, Yang Z., Chen L.F. Chem. Eng. J Vol. 52. P. B Matser A.M., Krebbers B., van den Berg R.W., Bartels P.V. Trends in Food Science & Technology Vol. 15. P Zhang J., Dalal N., Gleason C., Matthews M.A., Waller L.N., Fox K.F., Fox A., Drews M.J. J. of Supercritical Fluids Vol. 38. P Spilimbergo S., Bertucco A., Lauro F.M., Bertoloni G. Innovative Food Science and Emerging Technologies Vol. 4. P Garcia-Gonzalez L., Geeraerd A.H., Spilimbergo S., Elst K., Van Ginneken L., Debevere J., Van Impe J.F., Devlieghere F. Int. J. of Food Microbiology Vol P. 1. INACTIVATION OF MICROORGANISMS USING SUPERCRITICAL CO V. Suslov, 1 I. N. Suslova, 1 B.F. Yarovoy, 2 08.Yu. Shadrin*, Murzin, 2 N.V. Sapozhnikova, Lumpov, S. Dormidonova 1 Konstantinov Institute of Nuclear Physics, Gatchina, Russia 2 Khlopin Radium Institute, Saint-Petersburg, Russia The studies, in which the possibility of utilization of compressed CO 2 as an environmentfriendly (00green03) alternative sterilizing agent is demonstrated, are reviewed. Also, suggested in literature mechanisms of inactivating action of CO 2 onto various microorganisms are analyzed as influenced by various operation factors such as pressure, temperature, duration, type of microbes, and treated material. Key words: supercritical CO 2, inactivation, sterilization, microorganisms.