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1 1306ｨｺ ｨｰｨｪ0602 ｨｬｨｪ02ｨｪｨｨ ｨｪ06 ｨ 04ｨｰｨｹ ｨｰ0802ｨ 0609ｨ ｨｪ06! 01 1 (3) ｨ ｨｺ02ｨｨ06ｨｪｨｪｨ 07 ｨｺ ｨｨ ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨ ｨｰ0205ｨｹｨｪ0602 ｨｮ ﾂ ｨｪｨｨ ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ 08ｨ ｨ ｨｪｨｨ ｨｨｨｦ09ｨｺｨｨｨｦ ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ04ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨｨｦ ｨｮｨｪｨｨ ｨｨｨｰ02ｨｰ ｨ 05ｨｹｨｪ ｨ 0002ｨｪｨｰ09ｨｰ09ｨ ｨ ｨ ｨｪ02ｨｪｨｨ06 ｨｨ ｨｨｨ 05ｨｹｨｪ06ｨｬｨｮ 08ｨ 0409ｨｨｨｰｨｨ0603 ( ｨ 09ｨ ) 0806ｨｪ01 08ｨ 0409ｨｨｨｰｨｨ ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｨｨｰｨｨｨｺｨｨ ｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｨｨ ｨｨ ｨｺ ｨｬｨｨｨｰ02ｨｰｨ ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｨｨｰｨｨｨｺ02 ｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｨｰｨ ｨ 02ｨｨｨｨ ｨ 05ｨｹｨｪ ｨ 08ｨ ｨｪｨｨ ｨｨｨｦ09ｨｺ06ｨｦ ｨ 02ｨｨｨｨ ｨ ｨｺ02ｨｨ07: ｨｬ0205ｨｹ07ｨｪ060909ｨｺｨｨｨｦ 0005ｨ 09ｨｪ04ｨｦ ｨ ｨｺｨｰ ｨｺ0902ｨｪｨｰｨｹ0209ｨ 04ｨ ｨｬ ｨ ｨｺｨｰ0608ｨ ｨｪｨ ｨｮ ﾂｨｪ04ｨｦ ｨ ｨｺｨｰ ｨｪ09ｨｺｨ 07 04ｨ ｨｮ06ｨｴｨ ｨ ｨｺ02ｨｨ02ｨｦ ｨ ｨｺ02ｨｨｨｨ: ｨｨ07, , ｨｺ09ｨ, ｨｮ ｨ 09ｨｪ ｨｰｨ 0809ｨｺｨ 07, 0106ｨｬ 16, 09ｨｰ : + 7 (495) fondhelios@yandex.ru ｨ ｨｰ0205ｨｹ: ｨ ｨｰ0205ｨｹ09ｨｰ ｨｨｨｮｨｬ ｨｨ0401ｨ ｨｰ0205ｨｹ09ｨｰ09ｨ : ｨｨ07, , ｨｺ09ｨ 02ｨｬｨｨｨｰ ｨｺ , 0106ｨｬ : + 7 (495) info@folium.ru 0509ｨｨ0102ｨｰ0205ｨｹ09ｨｰ ｨｨ09ｨｰ08ｨ 02ｨｨｨｨ , ｨ ｨｪ06 21 ｨｨ ｨ 05ｨｹｨｪ06ｨｦ 0905ｨｮ03ｨ 06ｨｦ 0706 ｨｪｨ ｨｮ ｨｨ, ｨｨｨｪ000608ｨｬｨ 02ｨｨ06ｨｪｨｪ0401 ｨｰ0201ｨｪ ｨｨｨｦ ｨｨ ｨｬｨ ｨｺ06ｨｬｨｬｨｮｨｪｨｨｨｺｨ 02ｨｨｨｦ (040609ｨｺ06ｨｬｨｪｨ ). 06ｨｨ08ｨ 03 ｪ ｨｺ ｨ ｨｰ0205ｨｹ ｨ ｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｺ ｨｨｨｨ ｨｨｨｪ 0802ｨｺｨｰ ｨｨｨｦ09ｨｺ ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ ｨｮｨｪｨｨ ｨｨｨｰ02ｨｰｨ ｨｨｨｬ ｨｨ ｨ, ｨｬ0201. ｨｪｨ ｨｮｨｺ, , ｨ ｨｺｨ 0102ｨｬｨｨｨｺ ｨ ｨｬ ｨ ｨｰ ｨ ｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｺ ｨｨｨｨ ｨｰ0802ｨｪｨｺ ｨ ｨｰ0205ｨｹ 0806ｨｬｨｨｨｰ02ｨｰｨ ｨｰｨ ｨ 02ｨｨｨｨ ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｨｨｰｨｨｨｺ02 ｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ06, 04ｨ ｨｬ0209ｨｰｨｨｨｰ0205ｨｹ ｨ ｨｰ ｨｰｨ ｨ ｨｬ ｨｨｨｪ09ｨ 05ｨｨ ｨｨ ｨ ｨｰ ｨｰｨ ｨ 02ｨｨｨｨ ｨ 05ｨｹｨｪ ｨ 08ｨ ｨｪｨｨ ｨｨｨｦ09ｨｺ06ｨｦ ｨ 02ｨｨｨｨ, ｨｪｨ ｨｮｨｺ ﾁ0502ｨｪ ｨ ｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｺ ｨｨｨｨ: ｨｪｨｰ06ｨｪ0609ｨ (000609ｨｺ09ｨ ) ｨｮｨｰ06ｨｪ0609 (000609ｨｺ09ｨ ) ｨ (000609ｨｺ09ｨ ) ｨｰ (000609ｨｺ09ｨ ) ｨ ｨｪｨｰ (05ｨ ｨｪｨｺｨｰ-0302ｨｰ0208ｨ ｨｮ0800) ｨｬｨｨｨｰ08ｨｨ0209 (000609ｨｺ09ｨ ) ｨ ｨｨｨｪ (05ｨ ｨｪｨｺｨｰ-0302ｨｰ0208ｨ ｨｮ0800) ｨｪ0609ｨ (000609ｨｺ09ｨ ) ｨ ｨｺ09ｨｨｨｬｨｺｨｨｨｪｨ (000609ｨｺ09ｨ ) ｨｺ060909ｨｺｨｨｨｦ (000609ｨｺ09ｨ ) ｨ ｨｬｨ ｨ -09ｨ 08ｨ ｨｪ0609ｨ (000609ｨｺ09ｨ ) ｨｬ02ｨｪ0609 (000609ｨｺ060909ｨｺｨ 07 06ｨ 05ｨ 09ｨｰｨｹ) ﾂ0209 (090205ｨ 08ｨｮ09ｨｹ, 00ｨｨｨｪ09ｨｺ) ｨ ﾂｨ ｨｰ0807ｨｪ (000609ｨｺ09ｨ ) ﾁｨ ｨ (000609ｨｺ09ｨ ) ｨｨｨｬｨ ｨｪ060909ｨｺｨｨｨｦ (000609ｨｺ09ｨ ) ｨｨ07ｨｺ0609 (000609ｨｺ09ｨ )

2 ｨｨ02ｨｨｨｪ09ｨｺｨｨ02 ｨｰ0201ｨｪ ｨｨｨｨ ｨｪｨｺｨ ｨｨ 0904ｨ ｨｨ01ｨ ｨｦ050609ｨ ｨｰｨｮ07ｨｨｨｰ0205ｨｹｨｪ ｨｺｨ 04ｨ ｨｰ0205ｨｹｨｪｨ 07 ｨｬ0201ｨｨ02ｨｨｨｪｨ 0402ｨ ｨ ｨ ｨｮ ﾂｨｪ ｨ 0609ｨｪ0609ｨ ｨｪｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ ｨｨｨｦ ｨｨｨｪｨｨｨｺ06-05ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺｨｨｨｦ ｨ ｨｪｨ 05ｨｨ04 00ｨ 0800ｨｨ0209ｨ , 09ｨ ｨｦ , ｨ ｨｪ , ｨｮｨｪ09ｨｺｨ , 0809ｨｺ0902ｨｪｨｰｨｹ0209ｨ ｨ 08ｨｬｨ ｨｺ0605ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺｨｨｨｦ ｨ ｨｪｨ 05ｨｨ ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 ｨｬ02ｨｰｨｨ ｨｪｨｨ ｨｪｨ ｨ ｨｪｨ ｨｰｨ (ｨ 0109ｨ ｨｪｨｰｨ ｨｪ) 0708ｨｨ 0502 ﾂ02ｨｪｨｨｨｨ ｨ ｨｰ0607ｨｨ ﾂ0209ｨｺ ｨｬｨ ｨｰｨｨｨｰｨ ｨｨ 05ｨｺ0402ｨｬ ｨ ﾂｨ ｨｰ0807ｨｪ , 05ｨｺ060806ｨ 0600ｨ ｨｰ0609ｨ , 0000ｨ 09ｨｬｨ ｨｪ ｨｴ0208ｨ 06ｨｰ ｨ 05ｨｺ ｨｨ04ｨｬｨ ｨ ｨ 06ｨｰ0601ｨ ｨｰ ｨｮ01ｨ ｨｺ0609ｨ ｨ 08ｨｬｨ ｨｺ0605ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺｨｨ02 ｨ ｨｺｨｰ04 ｨｨｨｪ00ｨ ｨｨ06ｨｪｨｪ06ｨｦ ｨｨ 09ｨｪｨｮｨｰ08ｨｨ0902ｨｪｨｪ06ｨｦ ｨ ｨｪ0209ｨｰ0204ｨｨｨｨ ｨｺ ｨｰｨｪｨ ｨｪｨｺｨ 02ｨｬ0205ｨｹ07ｨｪ060909ｨｺｨｨｨｦ , 05ｨｮ08ｨ , ｨｪｨｨｨｺ0609ｨ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨｰ04. 08ｨ ｨｺ ｨｪｨｨｨｰｨｹ ｨｨｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ0609ｨｰｨｹ? ｨｰ ｨｨ07 02ｨｬ0205ｨｹ07ｨｪ060909ｨｺｨｨｨｦ , 0809ｨｺ0902ｨｪｨｰｨｹ0209ｨ , ｨｺｨ ﾂ , ｨｪｨｨｨｺ0609ｨ ｨｰ0601ｨｨ ﾂ0209ｨｺｨｨ ｨ 0502ｨｬ04 ｨ ｨｪｨ 05ｨｨ04ｨ 09ｨｰ06ｨｨｨｬ0609ｨｰｨｨｨ ｨｪｨｨ ｨｪｨｨ04ｨ 02ｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｨｪｨｨｨｺ ｨｪ ｨｪｨｨ02 01ｨｨｨ 00ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｪｨｪ ｨｮ ｨｨｨｨ 09 ｨｮ ﾂ02ｨｰ06ｨｬ ｨｬ020301ｨｮｨｪｨ ｨｪ ｨｰｨ ｨｺｨ ｨｺ 0609ｨｪ0609ｨ ｨｪｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨ 0605ｨｹｨｪｨｨ ﾂｨｪ0401 ｨｮ ﾂ ｨｪｨｨｨｦ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ ﾂ02ｨｪｨｨ ｨ ｨｨｨｪ , 0609ｨ ｨｪ06ｨｺ ｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨｰ09ｨ ｨｨ ｨｨ01 ｨｬ0209ｨｰ ｨｨ09ｨｰ02ｨｬ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ ﾂ02ｨｪｨｨ ｨｨ06ｨｪ ｨｨｨｨ 0209ｨｹｨｺｨｨｨｪｨ , ｨｮｨ 02ｨｪ020209ｨ , 08ｨｮ04ｨｪ , 05ｨｨ0806ｨｰｨｺ ｨｪ09ｨｰ090609ｨ ｨｪｨｨ ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ 05ｨｹ0006ｨｰｨｪ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ ﾂ02ｨｪｨｨ ｨ ｨｬｨ 0809ｨｺ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ 09 ｨｨ ｨｹ040609ｨ ｨｪｨｨ02ｨｬ ｨｬｨ ｨｰｨｨ09ｨｪ ｨｮ05ｨｨ080609ｨ ｨｪｨｨ ｨ ｨｰ0609ｨ , 0006ｨｦ0907ｨｺ ｨｪ09ｨｰ090609ｨ ｨｪｨｨ02 ｨｪ0608ｨｬｨ ｨｰｨｨ09ｨｪ ｨ ｨｦ ｨ ｨ ｨｮ ｨｨ0701 ｨｬ ｨｪｨｨ04ｨ 02ｨｨｨｨ 09ｨｨ09ｨｰ02ｨｬ ｨ ｨ ｨｪ02ｨｪｨｨ ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ 0409ｨｨｨｰｨｨ02 06ｨｪｨｰ020809ｨｹ06: 06ｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ ｨｺ ｨｪｨｨ ｨ ｨｰ0609ｨｺｨｨ ｨｺ06ｨｺ09ｨ 05ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺｨ ｨ 08ｨｬ06ｨｰ08ｨ 0905ｨｨ ｨ ｨｺ09ｨｨｨｬ0609ｨ ｨｮｨｪｨ ｨｪ04ｨｦ ｨｰ ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ ｨｰｨｨｨｬｨｮ05ｨｨ080609ｨ ｨｪｨｨ07 ｨｨｨｪｨｪ0609ｨ 02ｨｨｨｦ 00ｨ 08ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ 06ｨｰ08ｨ ｨｬ ｨｪｨｪ0609ｨｰｨｨ ｨｬｨｨ080609ｨ ｨｪｨｨ02 ｨｰ0201ｨｪｨｨ ﾂ0209ｨｺｨｨ01 04ｨ 01ｨ ｨｪｨｨｨｦ 0708ｨｨ 04ｨ ｨｺｨｮ07ｨｺｨ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨｰ ｨ 09 ﾂ02ｨｰ ｨ ｨｰｨｪ ｨｰ ｨ , 09ｨｨ ﾂ02ｨｪ0609ｨ , ｨｺｨｨｨｦ ｨｰ02 ﾂ0209ｨｰ0902ｨｪｨｪ0402 ｨｨｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨｰ09ｨ : 09ｨｰｨ ｨｰｨｮ09 09ｨｨｨｪｨｰ02ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｰｨｨ01ｨｪ ｨ 08ｨ ｨｰ Medical technology assessment and choice EDITORIAL COLUMN Mikhailova D. O. Opening remarks... 3 NEWS DIGEST... 4 RESEARCH. ANALYSIS. EXAMINATION Evidence-Based Medicine Rebrova O. Yu. Scientific substantiation of medical technologies ｯ efficacy... 9 Clinical and Economic Analysis Margieva A. V., Hajlov P. M., Krysanov I. S., Korsunskaja I. M., Avxentyeva M. V. Pharmacoeconomic analysis of Methylprednisolone aceponate (Advantan) for treatment of atopic dermatitis and eczema Clinical and Economic Analysis Khachatryan G. R., Skorobogatova V. I., Tsfasman F. M. The burden of alcoholism on an employer Rudakova A. V. Pharmacoeconomic aspects of inhalation and intravenous anesthesia Expert Evaluation Omelianovsky V. V., Sura M. V., Sveshnikova N. D. New pharmaceuticals. How can innovativeness be assessed? Methodology Omelyanovsky V. V., Avxentyeva M. V., Derkach E. V., Sveshnikova N. D. Methodological issues of cost of illness analysis.. 42 POLITICS AND GOVERNANCE IN HEALTHCARE Upgrading Health Vyaznikov V. E. Introduction of internationally accepted Diagnosis-Related Groups methodology in Russia as a factor of increasing effectiveness of hospitals Drug Provision Kolbin A. S., Ivanuk A. B. Innovative pharmaceuticals and their place in drug supply system Regions of Russia Oskina E. A., Polubentseva E. I., Kuznetsov S. I., Sirotko I. I. Improvement of Drug Supply for privileged groups of population in Samara region with use of automated information systems Normative Regulation Soldatova I. G., Moisyak G. Yu. Improving normative and regulatory environment within the framework of healthcare system modernization project Professional Development Interview: Innovative approaches to addressing the issue of training highly skilled specialists for the pharmaceutical industry 74 INTERNATIONAL EXPERIENCE Maksimova L. V. International experience of state incentives for innovation in pharmaceutical and medical industries MASTER CLASS Perov K. A. Developing tender specifications for procuring drugs for public needs BACKGROUND Korobov N. V., Bichenova K. A., Yavorsky A. N. Domestic innovative drugs: synthetic peptides prospects TO AUTHORS

3 130009ｨｰｨｮ07ｨｨｨｰ0205ｨｹｨｪ ｨ 03ｨ 02ｨｬ0402 ﾂｨｨｨｰｨ ｨｰ0205ｨｨ! ｨｦ ｨｪ06ｨｬ ｨｮ08ｨｪｨ 05ｨ ｨｨ02ｨｨｨｪ09ｨｺｨｨ02 ｨｰ0201ｨｪ ｨｨｨｨ ｨｪｨｺｨ ｨｨ 0904ｨ ｨｴ02ｨｪ ｨ ｨｬ ｨｨｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ ｨｪｨｨｨｦ 09 09ｨｨ09ｨｰ02ｨｬ ｨ ｨ ｨｪ02ｨｪｨｨ ﾂｨｮ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ ｨｺｨｮ06 ｨ ｨｺｨｰｨｮｨ 05ｨｹｨｪ0609ｨｰｨｹ 05ｨｰ06ｨｦ ｨｰ02ｨｬ04 ｨｨ ｨｬ06ｨｦ ｨｪｨ 05ｨｹｨｪ04ｨｦ ｨｨｨｪｨｰ ｨｺ 01ｨ ｨｪｨｪ06ｨｦ ｨ 0502ｨｬ02. 04ｨ 0409ｨｨｨｰｨｨ02 00ｨ 08ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ ｨｪｨ ｨｮｨｺｨｨ ｨｪ07 ｪ 05ｨｰ06 ｨｬｨｮ05ｨｹｨｰｨｨ01ｨｨ0902ｨｨ0705ｨｨｨｪｨ 08ｨｪ04ｨｦ ｨｺ ｨ 0502ｨｬｨ ｨｬ, 09ｨｰ0607ｨｴｨｨｨｬ ｨ ｨ ｨｪ02ｨｪｨｨ02ｨｬ, ｨｮ01ｨ 0809ｨｰ0906ｨｬ ｨｨ ｨｬ 06ｨ ｨｴ0209ｨｰ0906ｨｬ, ｨｰ0802ｨ ｨｮ06ｨｴｨｨｨｬ 09ｨｨ09ｨｰ02ｨｬｨｪ0401 ｨｨ ｨｨｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ ｨｪｨｨｨｦ. 0201ｨｪｨ ｨｺ06 ｨｪｨｮ03ｨｪ ｨｪｨｨｨｬｨ ｨｰｨｹ, ﾂｨｰ06 ｨｰｨ ｨｺ0602 ｨｨｨｪｨｪ0609ｨ 02ｨｨｨｨ, ﾂｨｰ06 ｨｬ0603ｨｪ06 ｨｪｨ 0409ｨ ｨｰｨｹ ｨｨｨｪｨｪ0609ｨ 02ｨｨ07ｨｬｨｨ, ｨｺｨ ｨｺ ｨｨ01 ｨｺ05ｨ 0909ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｰｨｹ ｨｨ ｨｪｨｨｨｰｨｹ, ﾂｨｰ06ｨ 04 ｨｪ ｨ ｨｰｨｹ ｨｪｨｨ ｨｰ 05ｨｬ0602ｨｨ06ｨｪｨ 05ｨｹｨｪ0609ｨｰｨｨ 09ｨ ｨｬ ｨｰ ｨｪ07ｨｰｨｨ ｨｨ 05ｨｰ06ｨｬ ｨｨｨｬ02ｨｪｨｪ ｨｰｨ 09ｨｨｨｰ0205ｨｨ ｨｨｨｪ01ｨｮ09ｨｰ08ｨｨｨｨ 04ｨ ﾂｨ 09ｨｰｨｮ06 ｨｨ ｨｪ ｨ 06ｨ 0609ｨｪ0609ｨ ｨｪｨｪ06 ｨｨ ｨｹ04ｨｮ06ｨｰ 0706ｨｪ07ｨｰｨｨ02 00ｨｨｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ0609ｨｰｨｹ03 ｨｺｨ ｨｺ ｨｨｨｪ09ｨｰ08ｨｮｨｬ02ｨｪｨｰ ｨｨ0302ｨｪｨｨ07. 03ｨｮｨｰｨｨ ｨｨ0302ｨｪｨｨ ｨｮ ｨｪｨ 09, ｨｺｨ ｨｺ ｨｨ ｨｬ ｨｬｨｨ0802, 0609ｨｰｨ 06ｨｰ ｨｹ0204ｨｪ06ｨｦ ｨ 0502ｨｬ06ｨｦ. 00 ｨｰ ｨｬ07 09ｨｪ ｨｪｨｨ02 ｨｨｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ0401 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ ｨｨｨｦ, 09 ｨｰ06ｨｬ ﾂｨｨ ｨｨ ｨｪ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨｰ0609, ｨｬ060302ｨｰ 0708ｨｨ090601ｨｨｨｰｨｹ ｨｪ02 ｨｰ0605ｨｹｨｺ06 ｨｺ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｺ ｨｪｨｨ06 04ｨ ｨ ｨ ｨｪｨｨｨｦ, 04ｨｪｨ - ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｬｨｮ ｨｮ05ｨｮ ﾂ0302ｨｪｨｨ06 ｨｨ ﾂ02ｨｪｨｨ07 ｨｨ ｨｺｨ ﾂ0209ｨｰ09ｨ 03ｨｨ04ｨｪｨｨ, ｨｪ06ｨｨｨｺｨｮ090205ｨｨ ﾂ02ｨｪｨｨ06 04ｨ ｨｰ08ｨ ｨｰ 09ｨ ｨｬ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ ｨ ｨ ｨｪ02ｨｪｨｨ ｨｪｨｺｨ ｨｪ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ ｨｨｨｦ ｨｨ02ｨｨｨｨ ｨｨ ｨｪｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｰ0208ｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 0202ｨｪｨｪ0609ｨｰｨｨ ｨｨｨｬ02ｨｪｨｪ ｨ 02ｨｨ02ｨｪｨｰｨ ｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｨｬ ｪ 05ｨｰ06 ｨｰｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｺ ｨｨｨｪｨ ｨｰ, 09 08ｨ ｨｬｨｺｨ 01 ｨｺ06ｨｰ060806ｨｦ ｨｨ ｨｪ 0609ｨｮｨｴ0209ｨｰ090507ｨｰｨｹ ｨ ｨ 06ｨｰｨｺｨｨ ｨｮ0708ｨ ｨｪ ﾂ0209ｨｺｨｨ ｨｪｨｨｨｦ. 01ｨ ｨｮ01ｨ 0809ｨｰ ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ07 ｨｮ ｨｰ ｨｬｨｪ ｨｪｨｨｨｬｨ ｨｪｨｨ ｨｬｨｨ080609ｨ ｨｪｨｨ ｨｨｨｰｨｨｨｺｨｨ 0904ｨ 0608ｨ 0708ｨｨ0608ｨｨｨｰ02ｨｰ ｨｺｨ 04ｨ ｨｪｨｨｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ 0706ｨｬ06ｨｴｨｨ ｨｺｨ ｨｺ 0708ｨｨ ｨ ｨｰ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ ｨｰ0607ｨｪｨｨ0701, ｨｰｨ ｨｺ ｨｨ 0708ｨｨ ｨｮ ﾂ02ｨｰ02 ｨｪｨ ｨｨｨ ｨｨｨ 05ｨｹｨｪ06 ｨｮ ｨｪｨｪ ｨｮ0707 ｨｪｨ ｨｪｨｨ ｨｪｨ ｨｺ ｨｪｨｨ ｨｨ0608ｨｨｨｰ02ｨｰ0609, ｨｬｨｨ080609ｨ ｨｪｨｨ02 09ｨｰｨ ｨｪ01ｨ 08ｨｰ0609 ｨｨ 0904ｨ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨｰ0609 ｪ 05ｨｰ06 ｨｰ02 06ｨ 05ｨ 09ｨｰｨｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ, ｨ ｨｪ07ｨｰｨｪ0401 ｨｨ ｨ ｨ ｨｪｨｪ0401 ｨｺ08ｨｨｨｰ0208ｨｨ ｨｰｨ ｨｪ0609ｨｨｨｰ0907 ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺｨｨｨｬ 00ｨ ｨｺｨｰ060806ｨｬ 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ 09ｨｨ09ｨｰ02ｨｬｨｪ ｨｪｨｨｨｦ 04ｨ 01ｨ ﾂ, 09ｨｰ0607ｨｴｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ02ｨｬ ｨｨｨｦ09ｨｺ ｨ ｨ ｨｪ02ｨｪｨｨ02 09 ｨｰ02 ﾂ02ｨｪｨｨ ｨｪｨｨ ｨｰ ｨ 02ｨｰ ｨｹ0204ｨｪ04ｨｬ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07ｨｬ, ｨｪｨ 0708ｨ ｨｪｨｪ04ｨｬ ｨｪｨ ｨｰ 0102ｨｺ05ｨ 08ｨ ｨｰｨｨ09ｨｪ0401 ｨｰ02ｨｪ0102ｨｪ02ｨｨｨｦ ｨｺ ｨ ｨ 00ｨｬｨ ｨｰｨｨ ﾂｨｪ04ｨｬ, ｨｪｨｪ04ｨｬ ｨｪｨｨ07ｨｬ, 0609ｨｪ0609ｨ ｨｪｨｪ04ｨｬ ｨｪｨ ｨ ｨｨ09ｨｰ02ｨｬｨｪ06ｨｦ ｨｨ01 05ｨｺ ｨｰｨｨ0402 ｨｨ 00ｨｨｨｪｨ ｨｪ ｨｦ ｨ ｨ 06ｨｰｨｺ ｨｪｨｨ02 04ｨ ｨｺ06ｨｪ0601ｨ ｨｰ0205ｨｹｨｪ0402 ｨｨ ｨｪ0608ｨｬｨ ｨｰｨｨ09ｨｪ0402 ｨｪ ｨｪｨｨ07, ｨ 09ｨｰ09ｨｮ06ｨｴｨｨ ｨｪｨｨ06 09ｨｨ09ｨｰ02ｨｬｨｪ0609ｨｰｨｨ, 06ｨ ｨｲ02ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0708ｨｨｨｪ02ｨｨ ｨｨｨｪ07ｨｰｨｨ ｨｪｨｨｨｦ, ｨ ｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ06ｨｦ ｨｰ0806ｨｦｨｺ ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｦ 09ｨｨ09ｨｰ02ｨｬ ｨ ｨ ｨｪ02ｨｪｨｨ07, ｨｰｨ ｨｺ0302 ｨｪｨ 0305ｨｨ 06ｨｰ08ｨ 0302ｨｪｨｨ ｨ ｨｪｨｪ06ｨｬ ｨｪ06ｨｬ ｨｮ08ｨｪｨ 05ｨ ﾂｨｮ ｨ ｨｰｨｹ ｨ ｨｺ02ｨｨｨｨ 03ｨｮ08ｨｪｨ 05ｨ ｨｨ02ｨｨｨｪ09ｨｺｨｨ02 ｨｰ0201ｨｪ ｨｨｨｨ ｨｪｨｺｨ ｨｨ 0904ｨ ｨ ｨｪｨｨｨｰｨｹ ｨｪｨ ｨｰ08ｨ ｨｪｨｨ02ｨ 01 ｨ ｨｺｨｰｨｮｨ 05ｨｹｨｪ0609ｨｰｨｹ, 06ｨ ｨｲ02ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｹ 07ｨｮｨ 05ｨｨｨｺｨｮ02ｨｬ0401 ｨｬｨ ｨｰ0208ｨｨｨ , ｨｪ02 04ｨ ｨ 0409ｨ ｨｺ0802ｨ ｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｬ02 ｨｨ ｨ ﾂｨｨ ｨｮ09ｨ 0302ｨｪｨｨ02ｨｬ, ｨｨ01ｨ ｨｦ050609ｨ 01ｨｨ0802ｨｺｨｰ ｨ 08ｨｰｨ ｨｬ02ｨｪｨｰｨ 08ｨ 0409ｨｨｨｰｨｨ07 00ｨ 08ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ ｨｪｨｺｨ ｨｨ 0804ｨｪｨｺｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ ｨｰ0201ｨｪｨｨｨｺｨｨ 00ｨｨｨｪｨｨ09ｨｰ020809ｨｰ09ｨ ｨ ｨ ｨｪ02ｨｪｨｨ07 ｨｨ ｨｨｨ 05ｨｹｨｪ ｨ 0409ｨｨｨｰｨｨ ｨｨｨｦ09ｨｺ06ｨｦ ｨ 02ｨｨｨｨ, ｨｺｨ ｨｪ01. ｨｬ0201. ｨｪｨ ｨｮｨｺ

4 ｨ 00ｨ 02ｨｬ 00ｨ 0302ｨｬｨｮ 09ｨｪｨｨｨｬｨ ｨｪｨｨ06 06ｨ ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺ0609 ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ 09 06ｨ 05ｨ 09ｨｰｨｨ ｨｪｨｺｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ ｨｨｨｦ, ｨｪｨ ｨｮ ﾂｨｪ0401 ｨｨ ｨ ｨｪｨｨｨｦ, ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ ｨｺ06ｨｬ02ｨｪ01ｨ 02ｨｨｨｦ ｨ 0405ｨｨ ﾂｨｪ04ｨｬ ｨｪｨ 0708ｨ ｨｪｨｨ07ｨｬ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺｨｨ, ｨｰｨ ｨｺｨｨｨｬ, ｨｺｨ ｨｺ ｨｺｨ 0801ｨｨ ｨｨ07, ｨｪ ｨｨ07, 07ｨｮ05ｨｹｨｬ06ｨｪ ｨｨ07, 06ｨｪｨｺ ｨｨ07 ｨｨ 05ｨｪ0106ｨｺ08ｨｨｨｪ ｨｨ07, ｨ ｨｰｨ ｨｺ0302 ｨｪ ｨｰｨｨ 09 06ｨ 05ｨ 09ｨｰｨｨ ｨｮ0708ｨ ｨｪｨｨ07 ｨｨ ｨｮ05ｨｨ080609ｨ ｨｪｨｨ07 09ｨｨ09ｨｰ02ｨｬ ｨ ｨ ｨｪ02ｨｪｨｨ NICE ｨｪ ｨｺ06ｨｬ02ｨｪ010609ｨ 05 ｨｨ ｨｹ040609ｨ ｨｰｨｹ ｨ 0209ｨ 02ｨｨ04ｨｮｨｬｨ ｨ 09 ｨｺ06ｨｬｨ ｨｨｨｪｨ 02ｨｨｨｨ 09 06ｨｺ09ｨ 05ｨｨ0705ｨ ｨｰｨｨｨｪ06ｨｬ, 5-00ｨｰ0608ｨｮ08ｨ 02ｨｨ0506ｨｬ ｨｦｨｺ ｨｨｨｪ06ｨｬ ｨｨ05ｨｨ ｨｺｨ ｨｨｨｰｨ ｨ ｨｨｨｪ06ｨｬ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｬ02ｨｰｨ 09ｨｰｨ 04ｨｨ08ｨｮ06ｨｴｨｨｨｬ 08ｨ ｨｺ06ｨｬ ｨｰ060509ｨｰ ｨｺｨｨ0302 ﾂｨｪｨｨｨｺｨ ｨｨｨ 05ｨｹｨｪ06 08ｨ 0408ｨ ｨ 06ｨｰｨ ｨｪｨｪ06ｨｬ NICE 08ｨｮｨｺ ｨｰ ｨｪｨｺ02 ｨｰ0201ｨｪ ｨｨｨｦ, 0708ｨｨｨｬ02ｨｪ0706ｨｴｨｨ ｨｮ ｨｮｨｬｨｨ08ｨ 06ｨｴｨｨ01 07ｨ 02ｨｨ02ｨｪｨｰ0609 (00End of life guideline03), ｨｮｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｺ 09ｨｬ0203ｨ ｨｰ0205ｨｹ09ｨｰ09ｨ ｨｬ, ｨ 06ｨｴｨｨｨｬ 03ｨｨ04ｨｪｨｹ ｨ 0204ｨｪｨ ｨｪ06 ｨ 0605ｨｹｨｪ ｨｦ, 0708ｨｨｨｬ02ｨｪ0706ｨｰ0907 ｨｬ02ｨｪ ｨｰｨｺｨｨ02 ｨｺ08ｨｨｨｰ0208ｨｨｨｨ ｨｪｨｺｨｨ ｨｰｨｪ060302ｨｪｨｨ ｨ ｨｰ08ｨ ｨｰ04/ ｨｺｨｰ03, ﾂ02ｨｬ ｨｺ ｨｬ 0609ｨｰｨ 05ｨｹｨｪ04ｨｬ ｨｬ02ｨｰ0601ｨ ｨｬ 0502 ﾂ02ｨｪｨｨ ｨｪｨ ｨｺ06 05ｨｺ ｨｰ04 04ｨ ｨｰ, ﾂｨｰ ｨｺ0605ｨｹｨｺｨｮ ｨｰｨｪ060302ｨｪｨｨ ｨｪ04 ｨｨ ｨｪｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ ｨｹ ｨｰ 09ｨｺ0506 ﾂ02ｨｪｨｨ07 ｨ 0209ｨ 02ｨｨ04ｨｮｨｬｨ ｨ ｨ ｨｬｨｮ ｨｺ06ｨｬｨ ｨｨｨｪｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ ｨｮ ｨ 0605ｨｹｨｪ ｨｬ02ｨｰｨ 09ｨｰｨ 04ｨｨ08ｨｮ06ｨｴｨｨｨｬ ｨｺ ｨｺｨｰｨ 05ｨｹｨｪ04ｨｬ 08ｨ ｨｺ06ｨｬ ｨｰ0907 ｨｪ02ｨ 05ｨ ｨｨ07ｨｰｨｪ04ｨｬ, ｨｨｨｬ02ｨｪ02ｨｪｨｨ ｨ ｨｪｨｪ06ｨｬｨｮ 0706ｨｺｨ 04ｨ ｨｪｨｨ ｨ 02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ 0905ｨｮ03ｨ ｨ ｨ ｨｪ02ｨｪｨｨ07 08ｨｪ0005ｨｨｨｨ ｨｨ ｨｹ09ｨ ｨｪ02 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨ 0802ｨｪ ｨｰ06 ﾂｨｪｨｨｨｺ: NICE ( 0507ｨｨ0906ｨｺ 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨｨｦ ACC ｪ 08ｨｬ0208ｨｨｨｺｨ ｨｪ09ｨｺｨ 07 ｨｺ ｨｨ07 ｨｺｨ 0801ｨｨ ; ACA ｪ 08ｨｬ0208ｨｨｨｺｨ ｨｪ09ｨｺｨ 07 ｨｺｨ 0801ｨｨ ｨｨ ﾂ0209ｨｺｨ 07 ｨ ｨｨｨ 02ｨｨ07; AHRQ ｪ ｨｪｨｰ09ｨｰ ｨｨ ｨ ｨｪｨｨ07ｨｬ ｨｨ ｨｪｨｺ02 ｨｺｨ ﾂ0209ｨｰ09ｨ ｨ ｨ ｨｪ02ｨｪｨｨｨｨ ; CADTH ｪ 08ｨ ｨｪｨ 0109ｨｺ0602 ｨ 0002ｨｪｨｰ09ｨｰ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ04ｨｬ ｨ 08ｨ ｨｰｨ ｨｬ ｨｨ ｨｰ0201ｨｪ ｨｨ07ｨｬ ｨ ｨ ｨｪ02ｨｪｨｨｨｨ; EASD ｪ ｨｦ09ｨｺｨ 07 ｨ ｨｨｨ 02ｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨ06 01ｨｨｨ ｨ 02ｨｰｨ ; egfr ｪ ｨｰ0608 ｨｺ 0507ｨｨ010208ｨｬｨ 05ｨｹｨｪ06ｨｬｨｮ 00ｨ ｨｺｨｰ0608ｨｮ ｨｰｨ ; FDA ｪ ｨ ｨｪｨｨ ｨｪｨ ｨｮ 04ｨ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ04ｨｬｨｨ ｨ 08ｨ ｨｰｨ ｨｬｨｨ ｨｨ 07ｨｨｨｴ020904ｨｬｨｨ ｨｮｨｺｨｰｨ ｨｬｨｨ ; HAS ｪ 01ｨ 02ｨｨ06ｨｪｨ 05ｨｹｨｪ0602 ｨ 0002ｨｪｨｰ09ｨｰ ｨ ｨ ｨｪ02ｨｪｨｨ ｨ ｨｪ02ｨｨｨｨ; IQWiG ｪ 06ｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｺｨ ﾂ0209ｨｰ09ｨ ｨｨ 05ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺ06ｨｦ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｨｬｨ ｨｪｨｨｨｨ; NICE ｪ 01ｨ 02ｨｨ06ｨｪｨ 05ｨｹｨｪ04ｨｦ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｹ07 ｨｨ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ ｨｪ09ｨｰ090609ｨ ｨｪｨｨ ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ; SCAI ｪ 02ｨ ｨｴ0209ｨｰ ﾂｨｪ ｨｮ01ｨｨ09ｨｰ ｨｬ0203ｨ ｨｰ0205ｨｹ09ｨｰ09 ｨｨ ｨ ｨｪ00ｨｨ060008ｨ 00ｨｨｨｨ ; 0801 ｪ ｨ 08ｨｰ0208ｨｨｨ 05ｨｹｨｪｨ 07 00ｨｨ070208ｨｰ02ｨｪ04ｨｨ07; 0802 ｪ ｨ 08ｨｰ0208ｨｨｨ 05ｨｹｨｪ ｨ ｨｪｨｨ02; ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ ｨｨ06ｨｰｨｨｨｺ ﾂ02ｨｪｨｨｨｨ 0609ｨｰ0806ｨｦ 01ｨｨｨ 0802ｨｨ ｨｰ ｨｪｨ 0806ｨｺ08ｨ ｨｪ060909ｨｺｨｨｨｬ 09ｨｨ09ｨｰ02ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬ 06ｨ ｨｬ. 02ｨ 06ｨ ｨｴ02ｨｪｨｪ ｨｮ05ｨｹｨｰｨ ｨｰ ｨ ｨｪ0106ｨｬｨｨ04ｨｨ080609ｨ ｨｪｨｪ0401 ｨｨ ｨｺ09ｨ 04ｨｨ-08ｨ ｨｪ0106ｨｬｨｨ04ｨｨ080609ｨ ｨｪｨｪ0401 ｨｨ ｨ ｨｪｨｨｨｦ, ｨ ｨｰｨｨ0903ｨｨ ｨ ｨｴ02ｨｦ ｨｪ0609ｨｰｨｨ ｨ ｨ 02ｨｨ02ｨｪｨｰ0609 ( ｨｪ0609ｨｪ06ｨｬ 0102ｨｰ02ｨｦ), 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ ｨｨ07ｨｪｨｨ02ｨｬ ｨ ｨｨ06ｨｰｨｨｨｺ0609 ｨｨ ﾂ02ｨｪｨｨ02 ｨｪｨ 09ｨｰｨｮ07ｨ 02ｨｰ ｨ 0409ｨｰ ﾂｨ 09ｨｰｨｨ ｨｨ ｨ ｨｪｨｨｨｦ 0906ｨｺ08ｨ ｨｴｨ 05ｨ 09ｨｹ 0105ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 01ｨｨｨ 0802ｨｨ ( ｨｪ02ｨｬ ｨｪｨ 0601ｨｨｨｪ 0102ｨｪｨｹ), ｨｮ00ｨｨ01 08ｨ ｨ 06ｨｰｨ 01 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 09ｨｪｨｨ03ｨ 05ｨ 09ｨｹ ｨ 0605ｨｹｨｪ0401, ｨｮ ｨｺ06ｨｰ ｨｨｨ ｨ ｨｪ0705ｨ 09ｨｹ ｨｪｨ ﾂ02ｨｰ090208ｨｰ ｨｮｨｰｨｺｨｨ ｨｨ ｨｰｨ 02ｨｰ0907 ｨｪ ｨｪ04ｨｬ, ｨｪｨ 09ｨｺ0605ｨｹｨｺ06 06ｨｰ05ｨｨ ﾂｨ 06ｨｰ ｨｮ00 06ｨｰ 0108ｨｮ00ｨ 08ｨ 04ｨｪ ｨ 08ｨ ｨｰ04, ｨ ｨｴｨｨ ｨｪ0402 ｨ ｨ ｨｺｨｰ0208ｨｨｨｨ. 0809ｨｰ ｨｮ ｨｺ08ｨ ｨｪ060909ｨｺ ｨｨ09ｨｰ02ｨｬｨ ｨｰｨｨ- ﾂ0209ｨｺ ｨ ｨ, ｨｨ04ｨｮ ﾂｨ 0903ｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ ｨｨ06ｨｰｨｨｨｺ ｨｨ ｨｨ09ｨｰｨｨ08ｨｮ06ｨｴ02ｨｦ 01ｨｨｨ ｨｮ 0102ｨｰ02ｨｦ, 0708ｨｨ0305ｨｨ ｨｺ 04ｨ ｨｺ0506 ﾂ02ｨｪｨｨ06, ﾂｨｰ ｨｰ06ｨｦ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｨｨｰｨｮｨ 02ｨｨｨｨ 0609ｨｰｨ 02ｨｰ ｨｴ02 ｨｬｨｪ ｨｪ ｨｪｨｪ060006, 0106ｨｰ07 ｨｨｨｬ0206ｨｴｨｨ ｨｪｨｨ ｨｰ ｨｨｨｰｨｹ, ﾂｨｰ ｨ ｨｨ06ｨｰｨｨｨｺｨｨ ｨｨ 09 05ｨｰ06ｨｬ 0905ｨｮ ﾂｨ 02 ｨｬ0600ｨｮｨｰ ｨ 04ｨｰｨｹ ｨｪ ｨｪ ｨｬ02ｨｪｨｪ06 ｨｬ02ｨｰｨ -ｨ ｨｪｨ 05ｨｨ ｨ 0202ｨ 06-ｨｺ06ｨｪｨｰ ｨｬ ｨｨ ｨｪｨｨ02ｨｬ, ｨｪ02ｨｪｨｪ04ｨｦ , ｨｰ ｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ ｨｨ06ｨｰｨｨｨｺ0609, ｨ ｨｴｨｨ01 Lactobacillus, ｨｨ05ｨ ｨｺｨｰｨｨｨｺｨｨ ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ-ｨ ｨｨｨｨ080609ｨ ｨｪｨｪ06ｨｦ 01ｨｨｨ 0802ｨｨ ｨｮ ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 0601ｨｪｨ ｨｨ04 ｨｰ0201ｨｪ ｨｨｨｦ, 03ｨｨ0806ｨｺ06 ｨｨ ｨｹ04ｨｮ06ｨｴｨｨ ｨｰ02 ﾂ0209ｨｰ0902ｨｪｨｪ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺ02, ｨｰ ｨｹ 09ｨｰｨ ｨｪ0609ｨｨｨｰ0907 ｨｪｨ ｨｮ ﾂｨｪ06 06ｨ 0609ｨｪ0609ｨ ｨｪｨｪ06ｨｦ. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: The Cochrane Library ( reviews/en/ab html; en/ab html); Pharmacotherapy 2010;Feb;30(2):119ｨC HAS ｨｬ02ｨｰｨ -ｨ ｨｪｨ 05ｨｨ04 ｨｨ ｨ ｨｪｨｨｨｦ, 0908ｨ 09ｨｪｨｨ09ｨ 06ｨｴｨｨ01 01ｨｨｨ 00ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺｨｮ ｨｪｨｪ0609ｨｰｨｹ 09ｨｨ08ｨｰｨｮｨ 05ｨｹｨｪ06ｨｦ ｨｺ060506ｨｪ0609ｨｺ0607ｨｨｨｨ ｨｨ 06ｨ 04 ﾂｨｪ06ｨｦ ｨｺ060506ｨｪ0609ｨｺ0607ｨｨｨｨ ｨｪｨｨ02ｨｬ ｨｺ060506ｨｪ0609ｨｺ0607ｨ ｨｰ ｨｺｨｨ0302 ﾂｨｪｨｨｨｺｨ ｨｪｨｨ ｨｨ ｨｨ 01ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨｨ ｨｺ ｨｺｨｰｨ 05ｨｹｨｪ ｨ ｨｺｨ, ｨｹ06 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ 0802ｨｺ06ｨｬ02ｨｪ01ｨ 02ｨｨｨｦ ｨ ｨｰ02 09ｨｨ08ｨｰｨｮｨ 05ｨｹｨｪ06ｨｦ ｨｺ060506ｨｪ0609ｨｺ0607ｨｨｨｨ ｨｨ ｨｰ09 06ｨ ｨｴ0209ｨｰ0902ｨｪｨｪ ｨ ｨ ｨｪ02ｨｪｨｨ07. 02ｨ 06ｨ ｨｴ02ｨｪ ｨｮ05ｨｹｨｰｨ ｨｰ04 24 ｨｨ ｨ ｨｪｨｨｨｦ, ｨ ｨｰｨｨ0903ｨｨ01 ｨ ｨ 02ｨｨ02ｨｪｨｰ0609. ﾁｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨｨ ｨｨ00ｨｨ ﾂｨｪ0609ｨｰｨｹ 06ｨ 04 ﾂｨｪ06ｨｦ ｨｺ060506ｨｪ0609ｨｺ0607ｨｨｨｨ ｪ 0005ｨｨｨｺ02ｨｬｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｨｨｪ0102ｨｺ09; ｪ ｨｨ0302ｨｬｨｨ ﾂ0209ｨｺｨ 07 ｨ ｨｪｨｹ ｨ ; ｪ ｨｨｨｪ0102ｨｺ09 ｨｬｨ ｨｰ0205ｨ ; 0904 ｪ ｨｦ ｨｮ0106 ﾂ02ｨｺ; ｪ 05ｨｨ ｨｰ02ｨｨ0104 ｨｪｨｨ04ｨｺ06ｨｦ ｨｰｨｪ0609ｨｰｨｨ; ｪ ｨｬｨ 00ｨｪｨｨｨｰｨｪ ｨｪｨ ｨｪ09ｨｪｨ 07 ｨｰ06ｨｬ060008ｨ 00ｨｨ07; ｪ 0609ｨｰ0804ｨｦ ｨｨｨｪ00ｨ 08ｨｺｨｰ ｨｬｨｨ06ｨｺｨ 0801ｨ ; ｪ 0609ｨｰ ｨｪｨ 08ｨｮ0302ｨｪｨｨ02 ｨｬ ｨｺ ｨ 08ｨ ｨｴ02ｨｪｨｨ07; 0204 ｪ 06ｨｰｨｪ060302ｨｪｨｨ02 08ｨｨ09ｨｺ0609; ｪ 08ｨ ｨｪ0106ｨｬｨｨ04ｨｨ080609ｨ ｨｪｨｪ0602 ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｬ0602 ｨｨ090704ｨｰｨ ｨｪｨｨ02; 0502 ｪ 09ｨ 01ｨ 08ｨｪ04ｨｦ 01ｨｨｨ ｨ 02ｨｰ; ｪ ﾂｨｪ ﾂｨｪｨ ｨ ｨｪｨｨｨｬｨ 02ｨｨ07; ｪ 09ｨｺ0608ｨ 07 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨ ｨｬ06ｨｴｨｹ; ｪ ｨ ｨｺｨｰｨｨ09ｨｪ04ｨｦ ｨｰ02ｨｨｨｪ; ｪ ﾂｨｪ ｨｮ01ｨｨ09ｨｰ ｨ ｨ ｨ ｨｪｨｨ07; ｪ ﾂｨｪ ｨｮ01ｨｨ09ｨｰｨ 07 09ｨｨ09ｨｰ02ｨｬｨ ; ｪ ｨｪｨｨ ﾂ0209ｨｺｨ 07 06ｨ 09ｨｰ08ｨｮｨｺｨｰｨｨ09ｨｪｨ 07 ｨ ｨｪｨｹ ｨｺｨｨ01; ｪ ｨｪｨｨ ﾂ0209ｨｺｨ ﾂ02 ﾂｨｪｨ 07 ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪ0609ｨｰｨｹ; ｪ ｨｪｨｨ ﾂ0209ｨｺｨ ﾂｨｪｨ 07 ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪ0609ｨｰｨｹ.

5 1309ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ , ﾂ02ｨｬ 09ｨｨ08ｨｰｨｮｨ 05ｨｹｨｪ06ｨｦ, ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ06 06ｨｰ 08ｨ 04ｨｬ0208ｨ ｨ 0302ｨｪｨｨ ｨｨ04ｨｨ09ｨｰ06ｨｦ ｨｺｨｨ0302 ﾂｨｪｨｨｨｺｨ ｨｪｨｰ09ｨｰ ｨｨ ｨｺ 04ｨ ｨｺ0506 ﾂ02ｨｪｨｨ06, ﾂｨｰ06 09ｨｨ08ｨｰｨｮｨ 05ｨｹｨｪｨ 07 ｨｺ060506ｨｪ0609ｨｺ0607ｨｨ ｨｺｨ ｨｪ02 ｨｬ060302ｨｰ 04ｨ ｨｬ02ｨｪｨｨｨｰｨｹ 06ｨ 04 ﾂｨｪｨｮ06 ｨｨ 0802ｨｺ06ｨｬ02ｨｪ01ｨｮ02ｨｰ0907 ｨｰ0605ｨｹｨｺ ｨｨ ｨｪ ｨｬ0603ｨｪ0609ｨｰｨｨ ｨｰｨｨ ｨｪ ｨ ｨ ｨｪｨｨ02 ｨｰ060509ｨｰ ｨｺｨｨ0302 ﾂｨｪｨｨｨｺｨ ｨｺ060506ｨｪ0609ｨｺ060706ｨｬ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ ｨｮｨｰ09ｨｰ09ｨｮ06ｨｴｨｨｨｬｨｨ 04ｨ ｨ ｨ ｨｪｨｨ07ｨｬｨｨ, 06ｨｰｨｺｨ 04ｨ 0903ｨｨｨｬ ｨｰ 06ｨ 04 ﾂｨｪ06ｨｦ ｨｺ060506ｨｪ0609ｨｺ0607ｨｨｨｨ. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: HAS ( upload/docs/application/pdf/ /abstract_virtual_colonoscopy_meta-analysis_of_diagnostic_accuracy_indications_and_conditions_of_use_-_version_anglaise.pdf) ｨｺ0605ｨｹｨｺｨｮ ｨｬ06ｨ ｨｨ05ｨｹｨｪ0402 ｨｰ ｨｪ ﾂｨｪ ｨｨ ｨｪ0209ｨｪｨｮ06 03ｨｨ04ｨｪｨｹ, ｨ 08ｨ 04ｨｪ06 ｨｨ04ｨｮ ﾂｨｨｨｰｨｹ ｨｬ0603ｨｪ0609ｨｰｨｹ ｨｨ ｨｨ07ｨｪｨｨ07 ｨｪｨ 0108ｨｮ00ｨｨ ｨｺｨｰ0806ｨｪｨｪ0402 ｨｮ09ｨｰ0806ｨｦ09ｨｰ09ｨ, ﾂｨｰ ｨ 02ｨｪｨｪ06 09ｨ 03ｨｪ06 09 ｨｮ ｨｨ0701 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ ｨｮ ﾂ ｨｪｨｨ07. CADTH 0607ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｰ ﾂ00ｨｰ 06ｨ ｨｨｨｬ0206ｨｴｨｨ ｨｪｨ ｨｪ0703ｨｪｨｨｨｦ 0102ｨｪｨｹ 0106ｨｺｨ 04ｨ ｨｰ0205ｨｹ09ｨｰ09ｨ ｨｰ06ｨｦ ｨ 0502ｨｬ ｨ 09ｨｪ06 02ｨｬｨｮ, ｨｬ06ｨ ｨｨ05ｨｹｨｪ0402 ｨｰ ｨｪ04 ｨｬ0600ｨｮｨｰ ｨ 09ｨ ｨｰｨｹ 0706ｨｬ0201ｨｨ ｨｬ06ｨｪｨｨｨｰ0608ｨ ｨｬ ｨｨ 0409ｨｮｨｺ060904ｨｬ 09ｨｨ00ｨｪｨ 05ｨｨ04ｨ 02ｨｨ07ｨｬ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｮ09ｨｰ0806ｨｦ09ｨｰ09, ｨｪ06 ｨｨ ｨｨ07ｨｪｨｨ02 ｨｪｨ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｬｨ ｨｰｨｪ06. 01ｨ ｨｨｨ ｨ 08ｨ 04ｨｪ ｨ ｨｰｨｹ ｨｬ06ｨ ｨｨ05ｨｹｨｪ0402 ｨｰ ｨｪ04 ｨｪｨ 08ｨ 0909ｨｰ0607ｨｪｨｨｨｨ 0601ｨｪ ｨｬ02ｨｰ08ｨ 06ｨｰ ｨｺｨｰ0806ｨｪｨｪ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ ｨ 0608ｨｮ010609ｨ ｨｪｨｨ ｨｰ06 ﾂｨｪｨｨｨｺｨｨ: CADTH ( K0282_Cell_Phones_Hospitals.pdf) ﾂ ｨｪ06ｨｦ 0708ｨｨｨｬ0208 ｨｰ060006, ﾂｨｰ ｨ ｨｬ06ｨｰｨｪ0602 ｨｨ ｨｹ040609ｨ ｨｪｨｨ02 ｨｨｨｬ0206ｨｴｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ ｨｨｨｦ ｨｰ0907 ｨｪ02 ｨｰ0605ｨｹｨｺ ｨ 06ｨｬ ｨ 0608ｨｹｨ 04 04ｨ ｨｹ02, ｨｪ06 ｨｨ 05ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺｨｨ ｨｪ06, ｨｬ06ｨｪ09ｨｰ08ｨｨ080609ｨ ｨｪ ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ ｨ 09ｨｪ06 06ｨｰ ﾂ00ｨｰｨｮ ｨｺ06ｨｦ ｨｺ ｨｨｨｨ 01ｨｨ08ｨｮ , ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ ｨ ﾂ02ｨｦ, 08ｨ ｨ 06ｨｰｨ 06ｨｴｨｨ01 09 ｨｮ ｨｨ ｨｨ ﾂｨｪ06ｨｦ 0706ｨｬ06ｨｴｨｨ, ｨｪ ｨ ｨ 06ｨｰ 0802ｨｺ06ｨｬ02ｨｪ01ｨ 02ｨｨｨｨ NICE ﾂ02ｨｪｨｨ ｨｨ0802ｨｪｨｨ ｨｬ06ｨｴｨｹ06 ｨｬ02ｨｰ ｨ ｨ 08ｨｨｨ ｨｰ08ｨｨ ﾂ0209ｨｺ06ｨｦ 01ｨｨ08ｨｮ0800ｨｨｨｨ, ｨｺ06ｨｰ0608ｨ ｨｺｨ 04ｨ ｨｪｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ ｨ ｨｺ00/ｨｬ 2 ｨｨ ｨ ｨｨｨｨ080609ｨ ｨｪｨｪ04ｨｬｨｨ 09 ｨｪｨｨｨｬ 04ｨ ｨ ｨ ｨｪｨｨ07ｨｬｨｨ, ｨｪｨ 0708ｨｨｨｬ0208, ｨｰｨｨ07ｨ ｨｨ05ｨｨ ｨｬ0402 ｨｮｨ 04ｨｰｨｺｨｨ 06ｨｰ 0603ｨｨ0802ｨｪｨｨ07 ｨｨ ｨ ｨｪｨｪ ｨｪｨｨｨｬ ｨｪ ｨｨｨｦ ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ ｨｰｨ ｨｰ ｨ ,3 ｨｬ ｨｮｨｪｨｰ ｨｰ020805ｨｨｨｪ ｨｺ08ｨｨｨｰ0208ｨｨｨｨ ｨ ｨ 08ｨｨｨ ｨｰ08ｨｨ ﾂ0209ｨｺ06ｨｦ 01ｨｨ08ｨｮ0800ｨｨｨｨ ｨ 01ｨ 06ｨｰ 06ｨｺ ｨｬ05ｨｪ 03ｨｨｨｰ020502ｨｦ ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ ｨｪ02ｨｪｨｨ ｨ ｨｰｨｨ09ｨｪ ｨｬ0203ｨ ｨｰ0205ｨｹ09ｨｰ09ｨ 0106ｨｰ07 ｨ 04 ｨｮ 5 % ｨｨ04 ｨｪｨｨ ｨｨｨｰ 0905ｨｺ06ｨｪ06ｨｬｨｨｨｰｨｹ 09 ｨｰ02 ﾂ02ｨｪｨｨ ｨｰ 382 ｨｬ05ｨｪ 00ｨｮｨｪｨｰ0609, ｨｰ060001ｨ ｨｺｨ ｨｺ ｨｪｨｨ ｨ 02ｨｨｨｨ ｨｮ ﾂ02ｨｰ090208ｨｰｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｺ06ｨｪ06ｨｬｨｨｨｰ ｨｮ0302 1,3 ｨｬ ｨｮｨｪｨｰ ｨｬ02 ｨｰ060006, 0603ｨｨ01ｨ 02ｨｬｨ ｨ 06ｨｰ ｨｰｨ ｨｪ ｨｪｨｨ07 ｨｰ08ｨｮ ｨ ｨｪ0609ｨｰｨｨ ｨｨ ｨ ｨｴ02ｨｪｨｨ ｨｦ ｨｪｨ 08ｨ ｨ 06ｨｰｨｮ ｨｰｨ 09ｨｨｨｰ 06ｨｰ ｨｬ05ｨｪ 00ｨｮｨｪｨｰ ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 01ｨ ｨｪｨｪｨ 07 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨ 07 ｨｰ0201ｨｪ ｨｨ07 06 ﾂ02ｨｪｨｹ ｨ 0409ｨｰ ｨ 07 06ｨｺｨｮ07ｨｨｨｰ ｨｦ09ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨ ｨｨｨｦ ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ ｨｪ02ｨｪ ｨ 05ｨｨ ｨ 02ｨｨｨｦ. 0207ｨｨ09ｨ ｨｪｨｪｨ 07 09ｨｨｨｰｨｮｨ 02ｨｨ07 ｨｨｨｬ0202ｨｰ ｨｬｨｪ ｨ ｨｴ ｨｨｨｦ09ｨｺ06ｨｦ 0102ｨｦ09ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ06, ｨ ｨｺｨｰｨｨｨｺｨ 01ｨｨ08ｨｮ0800ｨｨ- ﾂ0209ｨｺ ﾂ02ｨｪｨｨ ｨｨ0802ｨｪｨｨ07 08ｨ ｨｰ08ｨ ｨｪ02ｨｪｨ 09 02ｨｴ00 ｨｬ02ｨｪｨｹ0302ｨｦ 09ｨｰ020702ｨｪｨｨ ｨｨ ｨｮ06 06 ﾂ ｨｹ ｨｨ ｨｹ04ｨｮ02ｨｰ0907 ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ06 ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪ04ｨｦ ｨｰ06 ﾂｨｪｨｨｨｺ: NICE ( newsroom/news/surgeryfor- ObeseCouldSaveMillions.jsp) ｨｨｨ 05ｨｨ09ｨｰ04 IQWiG 0607ｨｮｨ 05ｨｨｨｺ0609ｨ 05ｨｨ ｨｨｨｰｨ ｨｪ09ｨｺ06ｨｬ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｬ 03ｨｮ08ｨｪｨ ｨｰｨ ｨｰｨｹｨｨ ｨ 0502ｨｬｨ ｨｨ09ｨｺｨ ｨｰ ｨｪ06ｨｦ ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ 0708ｨｨ ｨｪｨｨｨｨ ｨｪｨｺｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ ｨｨｨｦ ｨｪｨ 0708ｨｨｨｬ ｨ ｨｪｨｰｨｨ ｨ ｨｪｨｰｨ 0802ｨ 06ｨｺ0902ｨｰｨｨｨｪｨ. 02ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ02 ｨｰ0802ｨ 0609ｨ ｨｪｨｨ07 ｨｺ ｨｨ ｨｨｨｰ020507ｨｬ ｨ 08ｨ ｨｰ ｨ 0704ｨ ｨｰ0205ｨｹｨｪ06ｨｬ ｨｺ02 07ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｰｨｹ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ ｨ ｨｪｨｨｨｦ 0708ｨｨ090601ｨｨｨｰ ｨｺ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ04ｨｬ ｨｨ09ｨｺｨ 0302ｨｪｨｨ07ｨｬ 0708ｨｨ ｨｪｨｺ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ ｨ ｨ 09ｨｪ0609ｨｰｨｨ ｨｰ0201ｨｪ ｨｨｨｦ. 06ｨ ｨｺ, 09ｨ 03ｨｪｨｮ06 ｨｨｨｪ000608ｨｬｨ 02ｨｨ ｨ 06ｨｺ0902ｨｰｨｨｨｪ02, ｨ ｨｴｨｮ ｨｪ ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｪ0401 ｨｪｨｨ ｨｰ ﾂ02ｨｰｨ 01, 05ｨｺ ｨｰｨ ｨｬ IQWiG ｨｮ01ｨ ｨｹ ｨｮ ﾂｨｨｨｰｨｹ ｨｰ0605ｨｹｨｺ ｨ ｨｪｨｨ02ｨｬ 06ｨ ｨｴ0209ｨｰ0902ｨｪｨｪ0609ｨｰｨｨ ｨｨ ｨｮ ﾂｨｨｨｰ0409ｨ ｨｰｨｹ ｨｮ05ｨｹｨｰｨ ｨｰ , 09 ｨｰ06ｨｬ ﾂｨｨ ｨｪ020607ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｪ0401 ｨｨ ｨ ｨｪｨｨｨｦ, ｨｹ04ｨ 06ｨｰ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ ｨ 06ｨｺ0902ｨｰｨｨｨｪｨ 0906ｨｺ08ｨ ｨｴｨ 02ｨｰ ｨ 09ｨｪ02ｨｪｨｨ ｨ 06ｨ ｨｴ02ｨｪｨｪ04ｨｬｨｨ 01ｨ ｨｪｨｪ04ｨｬｨｨ ｨｰ0605ｨｹｨｺ ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｪ ｨ ｨ 06ｨｰ ｨｨｨ 05ｨｨ09ｨｰ04 IQWiG 09 ﾂｨｨｨｰｨ 06ｨｰ, ﾂｨｰ06 05ｨｰ06ｨｰ ｨｰ 0905ｨｮ03ｨｨｨｰ 0609ｨｪ0609ｨ ｨｪｨｨ02ｨｬ ｨｪ ｨｪｨｨ07 04ｨ ｨｺ06ｨｪ0601ｨ ｨｰ0205ｨｹｨｪ ｨｰ0802ｨ 0609ｨ ｨｪｨｨ07 07ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｰｨｹ ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ ｨ ｨｪｨｨｨｦ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨｰ0609, ｨｪ020502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0401 ｨｬ02ｨｰ ﾂ02ｨｪｨｨ07 ｨｨ ｨｨ ｨｨｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07 ｨｨ ｨｨ09ｨｰ08ｨｨ080609ｨ ｨｰｨｹ ｨｪｨ ﾂｨ ｨｰ0402 ｨｨ090704ｨｰｨ ｨｪｨｨ ｨｰ06 ﾂｨｪｨｨｨｺ: IQWiG ( index.1133.en.html); BMJ 2010;341:c4942; BMJ 2010;341:c ｨｦ, ﾂｨｰ06ｨ 04 ｨｰ0201ｨｪ ｨｨ07 04ｨ 08ｨ ｨ 06ｨｰｨ 05ｨ, ｨｰｨ ｨｰ06 ﾂｨｪ06 ｨｪｨ ﾂｨ ｨｰｨｹ 0708ｨ 09ｨｨ05ｨｹｨｪ ｨｨ ｨｹ040609ｨ ｨｰｨｹ ｨｪ06 ｨｨ ｨ ｨｪｨｨ02, 09ｨｰｨ 09ｨｨ ｨｦ ｨｹ06 ｨｨ04ｨｮ ﾂｨｨｨｰｨｹ ｨｬ02ｨｰ0601ｨｨｨｺｨｮ ｨ 0608ｨｹｨ ｨｺｨｮ0802ｨｪｨｨ02ｨｬ ｨｪｨｪ ｨｰｨｪｨｨ ﾂ0209ｨｺｨｨ ｨｮ0707ｨ 01, ｨ ｨｰｨ ｨｺ ｨｨ 05ｨｨ02 09 ｨｪｨｨ04ｨｺｨｨｨｬ ｨｬ ｨｰ ｨ 0405ｨｨ 0904ｨ 08ｨ ｨｪ04 ｨｪ0209ｨｺ0605ｨｹｨｺ ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ ｨｰ06ｨｬｨ ｨｰ ｨｨ ﾂ0209ｨｺｨｨ01 ｨｺ05ｨｨｨｪｨｨｨｺ, 09 ﾂｨ 09ｨｰｨｨ ｨｨ04 ｨｺ06ｨｰ ｨ ﾂｨｨ 0706ｨｬｨｨｨｬ ｨｨ ｨｪ0609ｨｪ ｨ 0704ｨ ｨｪｨｪ0609ｨｰ02ｨｦ ｨｪ02 ｨｰ0605ｨｹｨｺ ｨｪｨｨｨｰ0205ｨｹｨｪ ｨｨ05ｨｨ 08ｨ 04ｨｲ0709ｨｪｨｨｨｰ0205ｨｹｨｪｨｮ06 08ｨ ｨ 06ｨｰｨｮ ｨｺｨｮ0802ｨｪｨｨ07, ｨｪ06 ｨｨ 0708ｨｨ ｨｪ0206ｨ ｨｨｨｬ0609ｨｰｨｨ ｨｪｨ 04ｨｪｨ - ﾂｨ 05ｨｨ ｨｬ0201ｨｨｨｺｨ ｨｬ02ｨｪｨｰ0604ｨｪｨｮ06 ｨｰ0208ｨ 07ｨｨ06. ﾁ ,5 ｨｬ ﾂｨ 09ｨｰ06ｨｰｨ 09ｨｰ06ｨｦｨｺ ｨ ｨｪｨｨ07 06ｨｰ ｨｺｨｮ0802ｨｪｨｨ ｨｨ ｨｰ0201, ｨｺ ｨ ｨｺｨｰｨｨ09ｨｪ ﾂｨｨ05ｨｨ 09ｨｰ06ｨｬｨ ｨｰ ｨｨ, ｨ 0405ｨ , ﾂ02ｨｬ ｨｮ ｨｰ0201, ｨｺｨｰ ｨｰｨ ｨ ｨｨｨｰｨｹ ｨｺｨｮ08ｨｨｨｰｨｹ 09ｨ ｨｬ0609ｨｰ0607ｨｰ0205ｨｹｨｪ06: 5,3 ｨｨ 1,6 %, ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06 (p < 0,01). 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Am J Public Health 201;Jul;100(7):1307ｨC ｨｪｨ 05ｨｨ04 58 ｨｨ ｨ ｨｪｨｨｨｦ, ｨｪｨｪ ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ01 09ｨｰ08ｨ ｨｪｨ 01, 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 00ｨ 08ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨ02 ｨｺ06ｨｬ07ｨ ｨｪｨｨｨｨ ｨ ｨｪ04 06ｨｺｨ ｨ ｨｰｨｹ 0905ｨｨ07ｨｪｨｨ02 ｨｪｨ ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ ｨ 08ｨ ｨｰ ｨ ﾂｨ ｨｬｨｨ ｨｺｨｨ 04ｨ ｨｪｨｨ07ｨｬ ｨｬｨｪ0600ｨｨ ｨ ﾂ02ｨｦ 06 ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ ｨｨ ｨ 0608ｨ, ｨ ｨ 06ｨｰｨ 01 ｨ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ ｨｮ ﾂｨ ｨｮ ﾂ02ｨｪｨｨ07 ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ ｨ 08ｨ ｨｰ02 ｨｪｨ ｨｬｨｮ06 06ｨｰ ｨｨ ｨｨｨｰ020507, 0106ｨｺｨｰ0608 ｨ ｨｮ0102ｨｰ ｨｨ090409ｨ ｨｰｨｹ ﾂｨ ｨｴ ｨｴ ｨｪ ｨｨ ｨ ｨｪｨｨ07, ｨｪｨｪ ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ ｨｨ ｨ ﾂ02ｨｦ 06ｨ ｨｴ02ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺｨｨ, ｨ ｨｮ09ｨｰｨ ｨｪ ｨｪ06, ﾂｨｰ06 ｨｰ02, ｨｺｨｰ06 ｨｺ06ｨｪｨｰｨ ｨｺｨｰｨｨ080609ｨ ｨｰｨ 09ｨｨｨｰ020507ｨｬｨｨ 06ｨｰ010205ｨ ｨ 03 00ｨ 08ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｺ06ｨｬ07ｨ ｨｪｨｨｨｦ, 09ｨｺ0506ｨｪｨｪ ｨｨ090409ｨ ｨｰｨｹ ｨ ｨｰ0607ｨｴｨｨ ｨ 08ｨ ｨｰ ｨｰ06 ﾂｨｪｨｨｨｺ: Reuters ( idustre69j4ax ) ｨ 09ｨｰ00ｨｰ 09ｨｪｨｨｨｬｨ ｨｪｨｨ02 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ ｨ ｨｴ0209ｨｰ09ｨ ｨｺ ｨｰ06ｨｬｨｮ, ﾂｨｰ06 ｨｬｨｪ0600ｨｨ02 ｨｨ ｨ ｨｪｨｨ07, ｨｪｨｪ0402 ｨｪｨ ｨ 0605ｨｹ03ｨｨ ｨ 0608ｨｺｨ ｨｦ09ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｰ ｨｬｨ 0502ｨｪｨｹｨｺｨｨｨｦ ｨ 04ｨｬ0208ｨ ｨｬ ｨｺｨｰ, 0106ｨｺｨ ｨ 07 ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, ﾂｨｰ06 ｨｨ ｨｮ02ｨｬ04ｨｦ ｨ 08ｨ ｨｰ ｨｪ02 09ｨｰ0605ｨｹ ｨｺｨｰｨｨ0902ｨｪ, ｨｺｨ ｨｺ 0106ｨｰ ｨｹ ｨ 04 ｨｺ05ｨｨｨｪｨｨ02ｨｨ09ｨｰｨ ｨｬ, ｨ 03ｨ 06ｨｴｨｨｨｬ ｨｨｨｪｨｰ ｨｨ ｨｨｨｰ020502ｨｦ. 0207ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨ 09ｨｰｨ ｨｰｨｹ07, ｨｴ00ｨｪｨｪｨ 07 ｨ ｨｪｨ 05ｨｨ04ｨｮ 01ｨ ｨｪｨｪ06ｨｦ ｨ 0502ｨｬ04 ｨｨ ｨｬ02ｨｰ0601ｨ ｨｬ ｨｪｨｨ07, ｨｨ04 ｨｺ06ｨｰ060806ｨｦ ｨｮ02ｨｰ, ﾂｨｰ ｨｬｨ 0708ｨｨｨｪ07ｨｰｨｨ ｨｪｨｨ ｨ ｨｪｨｨｨｨ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ ｨ 08ｨ ｨｰｨ ｨｮ09ｨｺｨ 02ｨｰ ｨｪ02ｨ 0605ｨｹ03ｨｨ02 04ｨｪｨ ﾂ02ｨｪｨｨ07 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ07 08ｨｨ09ｨｺｨ. 06ｨｪｨ ﾂ , ｨｮ09ｨｰｨｨｨｬ04ｨｦ 08ｨ 04ｨｬ ｨｺｨｰｨ, 0102ｨｬ06ｨｪ09ｨｰ08ｨｨ08ｨｮ06ｨｴｨｨｨｦ ｨｨｨｬｨｮｨｴ0209ｨｰ09ｨ ｨ 08ｨ ｨｰｨ, ｨｪ ｨ 04ｨｰｨｹ ｨｮ090205ｨｨ ﾂ02ｨｪ ｨｬ02 ｨｰ060006, ｨｪ ｨｮ02ｨｰ ｨｪｨｨｨｬｨ ｨｪｨｨ02 ｨｮ ｨｰｨｹ 0706ｨｺｨ 04ｨ ｨｰ ｨｰｨｪ0609ｨｰｨｨ 0603ｨｨｨ ｨｺｨｨ, ｨ 06ｨ 08ｨ ｨｴｨ ｨｰｨｹ 09ｨｪｨｨｨｬｨ ｨｪｨｨ02 ｨｪｨ ｨｮ ﾂ02ｨｪｨｪ04ｨｦ ｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨｨｨｪｨｰ020809ｨ 05, ｨｺ06ｨｰ060804ｨｦ ｨｰ0907 ｨ ｨ 03ｨｪ04ｨｬ, ｨｨ ｨｪｨｨ 09 ｨｺ0602ｨｬ 0905ｨｮ ﾂｨ 02 ｨｪ02 ｨｮ08ｨ 09ｨｪｨｨ09ｨ ｨｰｨｹ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ ｨｨ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ04ｨｦ ｨｺｨｰ 06ｨｰ ｨ 08ｨ ｨｰｨ. 0208ｨｮ00ｨｨｨｬ ｨｪ ｨｰｨ ｨｰｨｺ06ｨｬ ｨ 0605ｨｹ03ｨｨ ｨ ｨｺ ｨｰ ｨｬ0603ｨｪ0609ｨｰｨｹ ｨｬ02ｨｪｨｰｨｨ080609ｨ ｨｪｨｨ07 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨｪｨ ｨｮ ｨｨ09ｨｺｨ ｨｨｨｰ0205ｨｹｨｪ ｨｺｨｰｨ, ｨｰ060001ｨ ｨｺｨ ｨｺ ｨｦ09ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨｺｨｰ 06ｨｰ ｨ 08ｨ ｨｰｨ ｨｬ0603ｨｪ06 06ｨ ｨｪｨ 08ｨｮ03ｨｨｨｰｨｹ ｨｨ 09 ｨｬｨ 0506ｨｦ ｨ 04ｨｬ0208ｨｮ 0904ｨ 0608ｨｺ ｨｰ06 ﾂｨｪｨｨｨｺ: J Natl Cancer Inst 2010;Aug;18;102(16): 1216ｨC1217, FDA 0708ｨｨｨｪ ｨｪｨｨ02 06ｨ 06ｨｰ ｨｪｨｺｨ 09ｨｰ08ｨ ｨｪ ｨ 08ｨ ｨｰｨ 09ｨｨｨ ｨｮｨｰ08ｨ ｨｬｨｨｨｪ (000208ｨｨ01ｨｨｨ, Abbott Laboratories). 02ｨｪ ｨｪ ｨ 02ｨｰ0907 ｨｪｨ ｨｮ05ｨｹｨｰｨ ｨｰｨ 01 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ ｨｨ090704ｨｰｨ ｨｪｨｨ07 SCOUT, ﾂｨ 09ｨｰｨｹ

6 ｨ ｨｬｨｬ ｨｰｨｬｨ 08ｨｺ02ｨｰｨｨｨｪ ｨｨ ｨ ｨｪｨｨｨｦ, 09 ｨｺ06ｨｰ060806ｨｬ ｨｨ04ｨｮ ﾂｨ ｨｹ 0905ｨｨ07ｨｪｨｨ02 09ｨｨｨ ｨｮｨｰ08ｨ ｨｬｨｨｨｪｨ ｨｪｨ ｨｰｨｪ0609ｨｰｨｹ ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬ ｨｪ06, ﾂｨｰ ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 ｨｮｨｺｨ 04ｨ ｨｪｨｪ ｨ 08ｨ ｨｰｨ ｨ ｨｹ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02ｨｬ ｨｪｨ 16 % 08ｨｨ09ｨｺｨ , ｨｨ ｨｺ06ｨｰ , , 0609ｨｰｨ ｨｪ0609ｨｺｨ ｨ ｨｨ 09ｨｬ0208ｨｰｨｹ. 0308ｨｨ 05ｨｰ06ｨｬ ｨ 09ｨｪ02ｨｪｨｨｨｨ ｨ 0202ｨ 06 ｨｨｨｬ0205ｨ 09ｨｹ ｨｪ02 09ｨｰ0605ｨｹ ｨｮ03 ｨｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪｨ ｨｰ ｨ, ｨ ｨｰ0205ｨｹｨｪ06 ｨｪ0200ｨ ｨｰｨｨ09ｨｪ ｨｰ09ｨｨ ｨｰｨｪ060302ｨｪｨｨｨｨ ｨｪ ｨ 05ｨｨ08ｨｮ06ｨｰ. 01ｨ 0609ｨｪ0609ｨ ｨｪｨｨｨｨ ｨｮ ﾂ02ｨｪｨｪ ｨ ｨｪｨｪ0401 FDA 0802ｨｺ06ｨｬ02ｨｪ010609ｨ ｨ ﾂｨ ｨｬ ｨｺ08ｨ ｨｰｨｨｨｰｨｹ ｨｨ090409ｨ ｨｰｨｹ ｨｰ04 ｨｪｨ 09ｨｨｨ ｨｮｨｰ08ｨ ｨｬｨｨｨｪ, ｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ ｪ ｨｺ08ｨ ｨｰｨｨｨｰｨｹ ｨｨ00ｨｬ ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｨ07 04ｨ ｨｪｨｨ07 FDA ｨｺ06ｨｬ07ｨ ｨｪｨｨ ｨｨ ｨｨｨｰ0205ｨｹ ｨ 09ｨｨ05ｨ 09ｨｹ 0106ｨ ｨｹｨｪ ｨｺ08ｨ ｨｰｨｨｨｰｨｹ ｨ 03ｨｨ ｨ 08ｨ ｨｰｨ. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: FDA ( Newsroom/PressAnnouncements/ ucm htm) AHRQ ｨｨ ｨｪｨ 0008ｨ ｨｪｨｨ ｨ 04ｨｬ ｨｬ05ｨｪ ｨ 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｮ ｨｺｨｰｨｨ09ｨｪ0401 ｨｬ ｨ 0608ｨｹｨ ｨｪ06ｨｦ ｨｨ ｨｨ01ｨｨ08ｨｮ06ｨｴｨｨ ｨｨ ﾂｨｨｨｪ 09ｨｬ0208ｨｰｨｨ ｪ 09ｨｪｨｮｨｰ08ｨｨｨ 0605ｨｹｨｪｨｨ ﾂｨｪ04ｨｬｨｨ ｨｨｨｪ0002ｨｺ02ｨｨ07ｨｬｨｨ ｨｪｨｨ07ｨｬ 0002ｨｪｨｰ ｨｺ06ｨｪｨｰ ｨｨ ｨｨ05ｨ ｨｺｨｰｨｨｨｺ02 04ｨ ｨ ｨ ｨｪｨｨｨｦ ｨｪ ｨｰ ｨｺ ｨｬ05ｨｪ 0905ｨｮ ﾂｨ ｨｪｨｮｨｰ08ｨｨｨ 0605ｨｹｨｪｨｨ ﾂｨｪ0401 ｨｨｨｪ0002ｨｺ02ｨｨｨｦ, ﾂｨｰ ﾂ00ｨｰ 04ｨ 0906ｨ 06ｨｦ 100 ｨｰ ｨｬ0208ｨｰ02ｨｦ ｨ 0502ｨｬｨ ｨ 02ｨｪｨｪ06 ｨ ｨｺｨｰｨｮｨ 05ｨｹｨｪｨ 09 ｨｮ ｨｨ ｨｰ0607ｨｪｨｪ06 08ｨ 09ｨｰｨｮｨｴ ﾂｨｨ0905ｨ ｨ ｨｬｨ ｨｮ05ｨ ｨｰ0608ｨｪ ｨ 02ｨｨｨｦ ｨｨ ｨ 0605ｨｹ ﾂｨｨ0905ｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609, ｨｪｨ ｨｴｨｨ ｨｰｨ 02ｨｨ06ｨｪｨ 08ｨ ｨｨｨｰ0205ｨｹｨｪ ｨ 0409ｨ ｨｪｨｨ07, ｨｪｨ 0708ｨｨｨｬ0208, 09 ｨｰ0208ｨｬｨｨｨｪｨ 05ｨｹｨｪ06ｨｦ 0706 ﾂ02 ﾂｨｪ06ｨｦ ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪ0609ｨｰｨｹ ｨｰ060006, ﾂｨｰ06ｨ ｨｺｨｰ 06ｨｰ ｨ ｨｪ0401 ｨｬ0208 ｨ 0405 ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ04ｨｬ, AHRQ ｨｰ08ｨｮ01ｨｪｨｨ ﾂ0209ｨｰ ｨｮ00ｨｨｨｬｨｨ ｨ ｨｪｨｨ04ｨ 02ｨｨ07ｨｬｨｨ, 09 ｨｰ06ｨｬ ﾂｨｨ ｨ 02ｨｨ06ｨｪｨ 05ｨｹｨｪ04ｨｬ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ06ｨｬ ｨｹ , ｨｰｨ 09ｨｨ ｨｨ0906ｨｺ ｨ 0502ｨｬ, ｨｴｨｨ ｨｬ02ｨｰ06ｨｬ ｨｪｨ ｨｮ ﾂｨｪ0401 ｨｨ040409ｨｺｨ ｨｪｨｨｨｦ ｨｨ ｨｪｨｨ01: ｨｪｨｨ02 ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺ0609 ｨｨ ｨｨ05ｨ ｨｺｨｰｨｨｨｺｨ 09ｨｪｨｮｨｰ08ｨｨｨ 0605ｨｹｨｪｨｨ ﾂｨｪ0401 ｨｨｨｪ0002ｨｺ02ｨｨｨｦ, ｨｮ05ｨｮ ﾂ0302ｨｪｨｨ ｨ ｨｺｨｰｨｨｨｺｨｨ ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ0609 ｨｨ ｨ ｨｰ0209ｨｪ ｨｰ08ｨｮ01ｨｪｨｨ ﾂ0209ｨｰ0906 ｨｬ020301ｨｮ 08ｨ 0405ｨｨ ﾂｨｪ04ｨｬｨｨ 0905ｨｮ03ｨ ｨ ｨｬｨｨ 09 09ｨｨ09ｨｰ02ｨｬ ｨ ｨ ｨｪ02ｨｪｨｨ ｨｰ06 ﾂｨｪｨｨｨｺ: AHRQ ( press/pr2010/haify10pr.htm) ｨｪ06ｨｬ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ07 ｨｺ06ｨｬ07ｨ ｨｪｨｨｨｦ ｨｨ ｨｨｨｰ020502ｨｦ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨｰ0609 ｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ ｨ 0608ｨｮ010609ｨ ｨｪｨｨ ｨ ｨｪ07ｨｺ06ｨｬ 09ｨｰ06ｨｨｨｰ ｨ 0502ｨｬｨ ｨｴ02ｨｪｨｨ07 ｨｰｨ ｨｺ ｨｪｨ ｨ 02ｨｬ ｨｺ06ｨｪ0005ｨｨｨｺｨｰｨ ｨｨｨｪｨｰ ｨｪｨｨｨｬｨ ｨｪ0609ｨｰｨｹ ｨｨ 0609ｨｰ0806ｨｰｨｮ ｨ 0502ｨｬ04, ｨｬｨｪ0600ｨｨ02 09ｨｰ08ｨ ｨｪ ｨｨｨｪｨｨｨｬｨ 06ｨｰ ｨｰｨｺｨｨ 0708ｨｨ01ｨ ｨｰｨｹ 05ｨｰ06ｨｬｨｮ ｨｮ ｨｨ ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬ ｨｰｨｮ07ｨｪ0609ｨｰｨｹ ｨｨ ｨ ﾂｨｪ0609ｨｰｨｹ. 00 ﾂｨ 09ｨｰｨｪ0609ｨｰｨｨ, ｨｰｨ ｨｰ02 00ｨ 0909ｨ ﾂｨｮ0902ｨｰ ｨ ｨｨｨｪ07ｨｰ 04ｨ ｨｺ06ｨｪ, 09 08ｨ ｨｬｨｺｨ 01 ｨｺ06ｨｰ ｨｮｨｰ ｨｪ ｨｺ ｨｪｨｨ ｨｨ ｨｨｨｰ ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨｰ0609 ｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｮ09ｨｰ0806ｨｦ09ｨｰ ｨ 09ｨｪ06 02ｨｬｨｮ, ｨｺ06ｨｬ07ｨ ｨｪｨｨｨｨ ｨｪ ｨｰｨ ｨｰｨｹ ｨｪｨｨ ｨ 04ｨｬ020802, ｨｨ ｨｨ ｨｮ ﾂｨ ｨｰ ｨ ｨｰ020302ｨｦ, ｨ 06ｨｴｨｨ ｨ 0609ｨｪ0609ｨ ｨｪｨｨｨｨ 05ｨｰ06ｨｦ ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ ｨ 0405ｨ 0607ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨ ｨ ｨ 04ｨ 01ｨ ｨｪｨｪ ｨ ｨｰ0203ｨ 01, ｨ ｨ ｨｪｨｪ ﾂ02ｨ ｨｪ04ｨｬ ｨｮ ﾂ ｨｪｨｨ07ｨｬ, 0908ｨ ﾂｨ ｨｬ, ｨｬ ｨｰ08ｨ ｨｬ ｨｨ 0108ｨｮ0006ｨｬｨｮ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｬｨｮ ｨｪｨ 05ｨｮ ｨｨ09ｨｺｨ 0908ｨ ﾂ02ｨｦ, ｨｮ ﾂｨｨ0903ｨｨ01 ｨｪｨ ｨｨｨ 0605ｨｹ03ｨｨ ｨ 04ｨｬ0208ｨ ｨｬ ｨ ｨｰ04, ｨ 0605ｨｹ ｨｺｨ 04ｨ ｨｹ ｨｺｨ 0801ｨｨ (4 ﾂ ｨｺｨ ). 00ｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ04ｨｦ 08ｨ 04ｨｬ ｨ ｨｰ ｨｨ ｨｰ ｨｨｨｬ02 ﾂｨ ｨｰ0205ｨｹｨｪ06, ﾂｨｰ ｨ ｨｰ ｨ ﾂｨ ｨｬ ｨｰｨ 09ｨｨ05ｨｨ ｨｨｨｪｨｮ 06ｨ ｨｴ02ｨｦ 09ｨｮｨｬｨｬ ｨｹ03ｨｨｨｪ09ｨｰ0906 ｨｨ04 ｨｪｨｨ01 06ｨ ｨｲ0709ｨｪ0706ｨｰ ｨｮ ﾂ02ｨｪｨｨ ｨ ｨｰ020302ｨｦ ｨｨｨｬ ｨｮ ﾂｨ 09ｨｰｨｨ02ｨｬ 09 08ｨ 0408ｨ ｨ 06ｨｰｨｺ ｨ ｨｬｨｬ ｨｨ ｨｬｨ ｨｰ0208ｨｨｨ ｨ ｨｬｨｺｨ 01 ｨｪ ｨｪ ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ 08ｨ ｨ ｨｪｨｨ ｨｰ06 ﾂｨｪｨｨｨｺ: Heartwire ( do#bib_1) ｨ 09ｨｨｨｰ0205ｨｹ09ｨｰ ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ ｨｨ ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ0609ｨｰｨｹ 04ｨ ｨｪ02ｨｪｨｨ02 06ｨ ｨｴ0209ｨｰ0902ｨｪｨｪ ｨ ｨｬｨｬ ｨ ｨ ｨｪ02ｨｪｨｨ07, ｨｰｨ ｨｺｨｨ01, ｨｺｨ ｨｺ 09ｨ ｨｺ02ｨｨｨｪｨ 02ｨｨ07, 09ｨｺ08ｨｨｨｪｨｨｨｪ00 ｨｨ ｨｰ.01., ｨｪｨ ｨｬ0209ｨｰｨｪ ｨ 09ｨｰｨｨ ｨｰ060006, ﾂｨｰ06ｨ ｨｬ06 ﾂｨｹ ｨｨｨｬ ｨｪｨｨｨｨ 05ｨｰｨｨ ｨ 0502ｨｬ, ｨ 02ｨｰ ｨｨｨ 05ｨｹｨｪｨ ｨｮ03ｨ ｨ 06ｨ ｨｴ0209ｨｰ0902ｨｪｨｪ ｨｹ07, ｨｺ06ｨｰ0608ｨ 07 ｨ ｨｮ0102ｨｰ 0906ｨｰ08ｨｮ01ｨｪｨｨ ﾂｨ ｨｰｨｹ 09 NICE ｨｹ ｨｮ ﾂ02ｨｪｨｨ07 ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ0401 ｨｨ ｨ 09ｨｰ0608ｨｨｨｰ02ｨｰｨｪ ｨ ｨｪｨｪ ｨｺｨ 04ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ, ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨ 05ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺ06ｨｦ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｰ0201 ｨｨ05ｨｨ ｨｨｨｪ0401 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ ｨｨｨｦ, ｨｪｨ 0708ｨ ｨｪｨｪ0401 ｨｪｨ ｨｹ02 06ｨ ｨｴ0209ｨｰ09ｨ ｨ 05ｨｨ04ｨ 02ｨｨｨｨ 01ｨ ｨｪｨｪ06ｨｦ 04ｨ 01ｨ ﾂｨｨ ｨ ｨ 0408ｨ ｨ 06ｨｰｨ ｨｪ ｨｪ060904ｨｦ ｨ ｨｰ, ｨ 09ｨｪ06 ｨｺ06ｨｰ060806ｨｬｨｮ ｨ 00ｨ 02ｨｰ ｨｪｨｨ02 4 ｨｬ ｨｮｨｪｨｰ ｨｰ020805ｨｨｨｪ , 0708ｨｨ ﾂ02ｨｬ 05ｨｰｨ 09ｨｮｨｬｨｬｨ ｨｪ02 04ｨ 09ｨｨ09ｨｨｨｰ 06ｨｰ 0108ｨｮ00ｨｨ01 09ｨｰｨ ｨｰ02ｨｦ ｨ ｨｰｨ. 05ｨ ｨｺｨｰｨｨ09ｨｪ0402 ｨｬ ｨ 0608ｨｹｨ ｨｰｨ ｨｺｨｨｨｬｨｨ 04ｨ ｨ ｨ ｨｪｨｨ07ｨｬｨｨ, ｨｺｨ ｨｺ ｨｺｨｮ0802ｨｪｨｨ02 ｨｨ 0603ｨｨ0802ｨｪｨｨ02, 0708ｨ 09ｨｨｨｰ0205ｨｹ09ｨｰ0906ｨｬ ｨ 00ｨ 02ｨｰ ｨｪｨ 0008ｨ ｨｪｨｨ ｨｰ06 ﾂｨｪｨｨｨｺ: NICE ( newsroom/news/localauthorities- PlacedRightAtTheForefront.jsp) ｨ 04ｨｰ06 ﾂｨｪ ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 ｨｪ ｨｰ0201ｨｪ ｨｨｨｦ ｨｬ060302ｨｰ 06ｨｺｨ 04ｨ ｨｰｨｹ0907 ｨｪ02 ｨｬ02ｨｪｨｹ0302ｨｦ ｨ 0502ｨｬ06ｨｦ, ﾂ02ｨｬ ｨｨ01 ｨｪｨｨ04ｨｺｨ ｨｰｨｮ07ｨｪ0609ｨｰｨｹ. 0306ｨｺｨ 04ｨ ｨｰ0205ｨｹｨｪｨ 09ｨｨｨｰｨｮｨ 02ｨｨ07, ｨｺ06ｨｰ0608ｨ 07 08ｨ ｨ - ﾂｨｨ09ｨ 02ｨｰ ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ01 03ｨｰｨ ｨｰｨ ｨｰｨｨｨｪ (060201ｨ 09) ｨｺｨ 0801ｨｨ ｨ 09ｨｨｨｪ00ｨｪ ｨｪ02ｨｪｨｨｨｨ ｨ 0605ｨｹ ﾂｨｨ0905ｨ 09ｨｰ02ｨｪｨｰｨｨ080609ｨ ｨｪｨｨｨｦ ｨｮ (ｨｮ09ｨｰｨ ｨｪ0609ｨｺｨ ｨ ｨｰ02ｨｪｨｰ0609 ｨｮ 0601ｨｪ ｨ 02ｨｨ02ｨｪｨｰｨ ) ｨ ｨｰｨ ｨｰ06 ﾂｨｪ0401 ｨｪｨ ｨｰ ｨｺｨ 04ｨ ｨｪｨｨｨｦ, ｨｪｨｨｨｨ ｨｬｨｪ060006ｨｺ08ｨ ｨｰｨｪ0401 ｨ ｨｪ00ｨｨ060008ｨ 00ｨｨｨｦ 0708ｨｨ ｨｪ0608ｨｬｨ 05ｨｹｨｪ ｨｮ05ｨｹｨｰｨ ｨｰｨ 01 ｨｪｨ 0008ｨｮ0406 ﾂｨｪ ｨ, ｨｨｨｬ0705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｺｨ 0801ｨｨ0609ｨｰｨｨｨｬｨｮ0507ｨｰ0608ｨ 0708ｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ 0706ｨｺｨ 04ｨ ｨｪｨｨｨｦ ｨｨ ｨｪ ｨｮ ﾂ02ｨｪｨｨｨｨ ｨｨｨｪ000608ｨｬｨｨ080609ｨ ｨｪｨｪ ｨ 09ｨｨ07 06ｨｰ 07ｨ 02ｨｨ02ｨｪｨｰｨ 06ｨ ｨｨ ｨｹ040609ｨ ｨｪｨｨｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ ｨｮ09ｨｰ0806ｨｦ09ｨｰ09ｨ 09ｨｪ02 06ｨ 0604ｨｪｨ ﾂ02ｨｪｨｪ ｨｺｨ 04ｨ ｨｪｨｨｨｦ ｨｨ 09 05ｨｰｨｨｨｬ ｨ ｨｪ ｨｰｨｹ 09ｨｮ0102ｨ ｨｪ0401 ｨｨ09ｨｺ ｨｪ04ｨｬ 06ｨ 08ｨ 0406ｨｬ 09 03ｨｰｨ ｨｰ ｨｨ0502ｨｪ01 ｨ 0405ｨｨ ｨｮ ｨｪ ｨ ｨｺｨ 0801ｨｨ ｨ ｨｨ ｨｰｨ ｨｺ ｨ ｨｪ04 09ｨｮ0102ｨ ｨｪ0402 ｨｨ09ｨｺｨｨ ｨｨ04-04ｨ ｨｮ09ｨｰｨ ｨｪ0609ｨｺｨｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ ｨｬｨｪ ｨｰ09ｨ 09ｨｰ02ｨｪｨｰ ｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ 0706ｨｺｨ 04ｨ ｨｪｨｨｨｦ ｨｰ ｨｰ0209ｨｰ0902ｨｪｨｪ06, ｨｪｨｨｨｺｨ 02ｨｰ ｨｬ040905ｨｹ ｨｮ0706ｨｰ0802ｨ 0502ｨｪｨｨ ｨｰ010205ｨｹｨｪ ｨ ﾂ02ｨｦ ｨｹ06 05ｨｨ ﾂｨｪ06ｨｦ ｨｪｨ ｨｺ ｨｮ ﾂｨ ｨ ﾂｨｨ 06ｨｰ09ｨｰｨ ｨｨ09ｨ 06ｨｰ ｨｨ02ｨｨ06 ｨｨ ｨｰ ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｰ060806ｨｪ04 ｨｺ ｨｨｨｰｨｮｨ 02ｨｨｨｨ, 08ｨ ｨｪｨｮ090302ｨｦ ｨ 0902, 08ｨ 04ｨ ｨｨ08ｨ ｨｰ0205ｨｹ09ｨｰ09ｨ 05ｨｺ ｨｰｨｪ ｨｰｨ ｨｪｨ ﾂｨ 05ｨｨ09ｨｹ ｨｰｨｨ ｨ ｨｪ06ｨｪｨｨｨｬｨｪ ｨ ｨｴ02ｨｪｨｨｨｦ ｨｮ0706ｨｰ0802ｨ 0502ｨｪｨｨ0701, ｨｨ0903ｨｨ ｨｰ060006, ｨｺｨ ｨｺ 0106ｨｺｨｰ0608ｨｮ ｨ 0405ｨ ｨｪｨ ｨｪ0609ｨｰｨｹ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ ｨｨ0802ｨｺｨｰ0608ｨ 09 09ｨｰ080607ｨｴ02ｨｬ ｨｨｨｰｨ ｨ ｨｺ ｨ 00ｨ 02ｨｰ 09ｨ ｨｬ ｨｨｨ 05ｨｨ09ｨｰ, ｨ ｨｪ06ｨｪｨｨｨｬｨｪ ｨ ｨｴ02ｨｪｨｨ07 ｨｪｨ 0708ｨ ｨｪ ｨ ｨｨｨｬｨｨ ｨｺ ｨ ｨｬｨｨ. 08ｨ 0801ｨｨ ｨｨ ｨｨ0502ｨｪ01ｨ ｨｰ ﾂｨｨｨｰｨ 02ｨｰ, ﾂｨｰ06 ｨ 0405 ｨｮ ｨｪ ｨｨ 09ｨｰｨ 05 06ｨ ｨｲ02ｨｺｨｰ06ｨｬ 09ｨｮ0102ｨ ｨｪ ｨ ｨｪｨｨ07 ｨｨ04-04ｨ ｨｰｨｪ060302ｨｪｨｨ07 ｨｺ ｨｪ02ｨｬｨｮ ｨｺ ｨｨ ｨ 01ｨｬｨｨｨｪｨｨ09ｨｰ08ｨ 02ｨｨｨｨ ｨｬ06ｨｰ0807 ｨｪｨ ｨｺｨ 03ｨｮｨｴｨｮ ｨ ｨ 09ｨｮ0801ｨｪ0609ｨｰｨｹ ｨ ｨｪ ｨ ｨｪｨｨｨｦ, ｨｰｨ ｨｺｨｨ ｨｮ ﾂｨ ｨｨ ｨｪ02 ｨｬ0600ｨｮｨｰ ｨｨｨｬ02ｨｰｨｹ ｨｬ0209ｨｰ06, ｨｺ0605ｨｹｨｺｨｮ ｨｰｨ ｨｰ06 ﾂｨｪ06 03ｨｨ0806ｨｺ ｨｨｨｪ07ｨｰｨ 0708ｨ ｨｺｨｰｨｨｨｺｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨ07 ｨｬｨｪ02ｨｪｨｨ07 ｨｺ ｨｨ ｨｪｨｺ ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｨ ﾂｨｨｨｪ ｨｪ0609ｨｰｨｨ 09ｨｨｨｰｨｮｨ 02ｨｨｨｨ ｨ ｨｪ02ｨｪｨｨ07 ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ06ｨｦ 06ｨ ｨｲ02ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ ｨｴ ｨｪ ｨｪｨｮ030102ｨｪ04 ｨ 0405ｨｨ 09ｨｬ0203ｨ ｨｰｨｹ ｨｰｨ 09ｨｨｨｰ0205ｨｨ ACC ｨｨ SCAI. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Heartwire ( do#bib 1) ﾁ ﾁ ｨｺ09ｨｨ0002ｨｪ06ｨｰ0208ｨ 07ｨｨ07 03ｨｨ0806ｨｺ ｨｨｨｬ02ｨｪ0702ｨｰ0907 ｨｺｨ ｨｺ 0708ｨｨ ｨ ｨｬｨ ｨｮ05ｨ ｨｰ0608ｨｪ06ｨｬ, ｨｰｨ ｨｺ ｨｨ 0708ｨｨ 09ｨｰｨ 02ｨｨ06ｨｪｨ 08ｨｪ06ｨｬ 0502 ﾂ02ｨｪｨｨｨｨ ｨｪ0201ｨ 09ｨｪ06 ｨ 0405ｨｨ ｨｺｨ 04ｨ ｨｪ ｨｬｨｪ02ｨｪｨｨ07 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06 ｨｪ0206ｨ ｨｨｨｬ0609ｨｰｨｨ ｨｨ ｨｪ0609ｨｰｨｨ 05ｨｰ ｨｬ02ｨｰ0601ｨ ｨ 09ｨｪ06 ACC/ACA, 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 ｨｺｨｨ ｨ 0708ｨｨ ｨｪ0209ｨｰｨ ｨ ｨｨ05ｨｹｨｪ06ｨｦ 09ｨｰ02ｨｪ06ｨｺｨ 0801ｨｨｨｨ ｨｨ05ｨｨ ｨｪ ｨｪ00ｨｪｨｪ06ｨｬ ｨ ｨｲ00ｨｬｨ ｨｬ02ｨｪｨｰｨ ST 06ｨｰｨｪ0609ｨｨｨｰ0907 ｨｺ ｨｬｨｮ ｨｺ05ｨ 0909ｨｮ 0802ｨｺ06ｨｬ02ｨｪ01ｨ 02ｨｨｨｦ ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ ｨｪｨｨｨｰ0205ｨｹｨｪｨ 07 06ｨｺ09ｨｨ0002ｨｪｨ 02ｨｨ ｨｰ ｨｮｨｬ02ｨｪｨｹ03ｨｨｨｰｨｹ 0609ｨｰ ｨｨ0302ｨｬｨｨ ﾂ0209ｨｺ ｨｪｨｨ02, ｨｺ0605ｨｹｨｺｨｮ ｨｮ ｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨｪｨ ｨ ｨ 02ｨｰ ｨｨ0706ｨｺ09ｨｨ ｨｰ09ｨｨ02 04ｨ 09ｨｰ ｨｨ01ｨｺ0609ｨｰｨｨ 09 ｨｬｨ 0506ｨｬ ｨｺ08ｨｮ0002 ｨｺ ｨ 08ｨ ｨｴ02ｨｪｨｨ07 ｨｨ ｨｪ02ｨ 0102ｨｺ09ｨ ｨｰｨｪ ｨｰｨｪ060302ｨｪｨｨ ｨｮ04ｨｨｨｨ ｨｨ 0902ｨｪｨｰｨｨ050702ｨｨｨｨ. 08ｨ ｨｺ 06ｨｺｨ 04ｨ ｨｹ, ｨ ｨｪ ｨｺ06ｨｬ02ｨｪ01ｨ 02ｨｨｨｨ ｨｪ ｨｰ ｨｪ ｨｬ06ｨｦ 0106ｨｺｨ 04ｨ ｨｰ0205ｨｹｨｪ06ｨｦ ｨ ｨ 0406ｨｦ 09 09ｨｨ ｨｮ05ｨｹｨｰｨ ｨｰ0609 ｨｺｨ ﾂ0209ｨｰ0902ｨｪｨｪ ｨｰｨｨ ｨｪ0609ｨｰｨｹ 05ｨｰ06ｨｬｨｮ ｨｨｨｬ0206ｨｴｨｨ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ090704ｨｰｨ ｨｪｨｨｨｦ 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ02 ｨｺｨｨ ｨ ｨｨ08ｨｮ02ｨｰ 09ｨ ｨ 04ｨｬ ｨｨ ｨｪｨｨ02

7 13ｨｮ080609ｨｪ07 ｨｰ08ｨ ｨｪ09ｨ ｨｬｨｨｨｪｨ 04, ﾂｨｰ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ 06ｨ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨｨｨ 0406ｨｪ04 ｨｪ02ｨｺ080604ｨ ｨｰ060006, ｨｪ0201ｨ 09ｨｪｨｨｨｦ 09ｨｨ09ｨｰ02ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ 06ｨ , ｨｪ02ｨｪｨｪ04ｨｦ 0906ｨｰ08ｨｮ01ｨｪｨｨｨｺｨ ｨｬｨｨ 0806ｨｺ08ｨ ｨｪ060909ｨｺ ｨ ｨｴ0209ｨｰ09ｨ, ｨｨ05 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 09ｨｬ0208ｨｰｨｪ0609ｨｰｨｨ ｨ ﾂ02ｨｬ ｨ 04ｨ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ , ｨｺ06ｨｰ060804ｨｬ ｨｪｨ 04ｨｪｨ ﾂｨ ｨｺｨｨ , ｨ 09ｨｪ02ｨｪｨｨｨｨ 09 ｨｰ02ｨｬｨｨ, ｨｺ06ｨｬｨｮ ｨｪｨ 04ｨｪｨ ﾂｨ ｨ 04 ﾂｨｪ04ｨｦ ｨｮ ｨｨ 09 05ｨｰｨｨｨｬ ｨｺ08ｨｮ07ｨｪ0402 ｨｺｨ 0801ｨｨ ｨｨ ﾂ0209ｨｺｨｨ02 ｨ ｨｨｨ 02ｨｨｨｨ ｨｰ ｨｬｨｪ02ｨｪｨｨｨｨ, ﾂｨｰ06 ｨｪ0206ｨ ｨｨｨｬ ｨｪｨｨｨｰ0205ｨｹｨｪ0402 ｨｨ ｨ ｨｪｨｨ ｨｪｨｨ07 ｨｨ09ｨｰｨｨｨｪｨｪ06ｨｦ ｨｨ 06ｨｺ09ｨｨ0002ｨｪ06ｨｰ0208ｨ 07ｨｨｨｨ ﾂ02ｨｪｨｨｨｨ ｨｰ06 ﾂｨｪｨｨｨｺ: Heartwire ( article/ do) ｨ ｨｬ 0907ｨ 0902ｨｪｨｨ07 03ｨｨ04ｨｪｨｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｰｨ ｨｪ0609ｨｺ06ｨｦ ｨ 09ｨｪ ﾂ02ｨ ｨｪ ｨｮ ﾂ ｨｪｨｨ ｨｰ ｨｪｨｨ ｨ 0502ｨｪｨｨ06, ｨ ｨｴ02ｨｬ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ ｨｮ ﾂｨ ｨ ｨｪｨｨｨｬｨ 02ｨｨ06ｨｪｨｪ0402 ｨｬ ｨｨ07ｨｰｨｨ ｨｪ0706ｨｰ ｨｮ ﾂｨ ｨｦｨｪ04ｨｬｨｨ ｨｨｨｬｨｨ, ｨｪ02 ｨｨｨｬ0206ｨｴｨｨｨｬｨｨ ｨｰｨ ｨｰ06 ﾂｨｪ ｨｮ080609ｨｪ ｨｰ0609ｨｺｨｨ, ｨｨ 08ｨｮｨｺ ｨｨｨｰｨｹ ｨｨ ｨｦ09ｨｰ09ｨｨ07ｨｬｨｨ 0708ｨｨ010601ｨｨｨｰ ｨｨ090702ｨｰ ﾂ0208ｨｮ ｨｰ ｨｹ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ ｨｪ06ｨｦ 0706ｨｬ06ｨｴｨｨ ｨｬ060302ｨｰ ｨ 09ｨｰｨｨ, ｨｺ0605ｨｹｨｺｨｮ ｨｪｨｪ04ｨｦ 09ｨｨ09ｨｰ02ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ 06ｨ ｨｺｨ 04ｨ 05, ﾂｨｰ ｨｮ ﾂｨ 02 09ｨｪ02ｨ 0605ｨｹｨｪｨｨ ﾂｨｪ06ｨｦ 0609ｨｰｨ ｨｪ0609ｨｺｨｨ ｨ 01ｨｨ090702ｨｰ- ﾂ0208ｨｮ ｨｮ02ｨｰ ｨｰ06 ﾂｨｨｨｰｨｹ0907 ｨｪｨ 06ｨ ｨｲ0709ｨｪ02ｨｪｨｨｨｨ ｨｰ0201ｨｪｨｨｨｺｨｨ ｨｰ0605ｨｹｨｺ06 09 ｨｺ06ｨｬ ｨｨ07ｨｬｨｨ 0008ｨｮ01ｨｪ06ｨｦ ｨｺ0502ｨｰｨｺｨｨ, ｨｪ ｨｨ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ06ｨｦ, 09ｨｺ0506 ﾂｨ 06ｨｴ02ｨｦ 02ｨｴ00 ｨｨ 0708ｨｨｨｪｨｮ01ｨｨｨｰ0205ｨｹｨｪｨｮ ｨｪｨｰｨｨ050702ｨｨ ｨｺｨｨ ｨｬ 0905ｨｮ ﾂｨ 02 ｨｪｨ ｨ ｨ 02ｨｰ0907 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ ｨｨ09ｨ 02ｨｬ0609ｨｰｨｨ ｨｪｨ 2,4 % (0204 = 1,22; 95 % ,01ｨC11,46). 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Lancet 2010;Nov;6;376(9752):1522ｨC ｨｬ06ｨｰ0807 ｨｪｨ ｨ 0605ｨｹ ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｺｨｰｨｨ09ｨｪ ｨｨ0706ｨｰ02ｨｪ04ｨｨ09ｨｪ ｨ 08ｨ ｨｰ0609, ｨ 0502ｨｬｨ ｨｨ09ｨｰ02ｨｪｨｰｨｪ06ｨｦ ｨｺ ｨｰ0208ｨ 07ｨｨｨｨ ｨｪ02ｨｬｨｮ 0609ｨｰｨ 00ｨｰ0907 ｨ ｨｺｨｰｨｮｨ 05ｨｹｨｪ06ｨｦ. 0701ｨｨ09ｨｨｨｰ0205ｨｹｨｪ06, ｨｪ ｨｪｨｨｨｬ ｨｨ04 07ｨｮｨｰ02ｨｦ ｨｪｨｨ07 ｨｬ060302ｨｰ 09ｨｰｨ ｨｰｨｹ ｨｪｨｨ02 01ｨｨ08ｨｮ0800ｨｨ ﾂ0209ｨｺｨｨ01 ｨｬ02ｨｰ ﾂ02ｨｪｨｨ07, 06 ﾂ00ｨｬ 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｰ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｨ06ｨｪｨｪ ｨｨ ｨ ｨｪｨｨ07 Symplicity HTN ｨ ｨｬｨｺｨ ｨｪ02ｨｪｨｨ07 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ ｨｨ09ｨｰ02ｨｪｨｰｨｪ06ｨｦ ｨｨ05ｨ 09ｨｹ 09ｨｨｨｬ07ｨ ｨｰｨｨ ﾂ0209ｨｺｨ ｨｪ020809ｨ 02ｨｨ ﾂ02ｨｺ 0708ｨｨ 0706ｨｬ06ｨｴｨｨ 08ｨ 01ｨｨ06 ﾂｨ 09ｨｰ06ｨｰｨｪ06ｨｦ ｨ ｨ ｨｨｨｨ ﾂ ｨｰ 0706 ﾂ02 ﾂｨｪ0401 ｨ 08ｨｰ0208ｨｨｨｦ, 05ｨｨｨ ｨ 05ｨ 09ｨｹ ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｪｨ 07 08ｨ ｨｪ0202 ｨｬ0201ｨｨｨｺｨ ｨｬ02ｨｪｨｰ0604ｨｪｨ 07 ｨｰ0208ｨ 07ｨｨ07. ﾁ ｨｰｨｹ ｨｬ ｨ 04ｨｪｨｨ02ｨ ｨｬ020301ｨｮ 0008ｨｮ0707ｨ ｨｬｨｨ 09 ｨｮ080609ｨｪ ｨｰｨ ｨ 33/11 ｨｬｨｬ 08ｨｰ.09ｨｰ. (p < 0,0001), 0708ｨｨ ｨｰ06ｨｬ ﾂｨｰ06 01ｨ ｨｪｨｪ04ｨｦ ｨｺｨｰ ｨ ｨｪ ｨｨ ｨｰ09ｨｨｨｨ, ｨ 09ｨ ｨｬｨ ｨｮ08ｨ ｨｪ02 ｨｨｨｬ0205ｨ 0706ｨ 06 ﾂｨｪ ｨｺｨｰ ｨｨｨｰｨｨｨｺｨｨ ｨｨ ｨ ｨｪｨｨ07 ｨｮｨｺｨ ｨ 06ｨｰ ｨｪｨ ｨｰ06, ﾂｨｰ06 ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ ﾂｨ ｨｰ050706ｨｴｨｨ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｰｨｹ ｨｪ0209ｨｺ0605ｨｹｨｺ06 04ｨ ｨｬ02 ﾂｨ ｨｪｨｨｨｦ. 02ｨｪｨｨ ｨｰ0907 ｨｺ ｨｰ06ｨｬｨｮ, ﾂｨｰ ｨｮ05ｨｹｨｰｨ ｨｰｨ 01 ｨ ｨｺ0202ｨｪｨｰ ｨ 02ｨｰ0907 ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ , ｨｮ ﾂ02ｨｪｨｪ ｨｬ07 09ｨｨ04ｨｨｨｰｨ ｨｺ 0908ｨ ﾂｨｮ, ｨｰ060001ｨ ｨｺｨ ｨｺ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｬｨ 03ｨｪｨｨ01 ｨｨ04ｨｬ020802ｨｪｨｨｨｦ ｨｪ02 09ｨｰ0605ｨｹ 0706ｨｺｨ 04ｨ ｨｰ0205ｨｹｨｪ ｨｰ06ｨｬｨｮ ｨｰ09ｨｮｨｰ09ｨｰ09ｨｮ02ｨｰ ｨｬ ｨ 09ｨｪ02ｨｪｨｨ02 09 ｨ ｨｪｨｰｨ 0006ｨｪｨｨ09ｨｰｨ ｨｬｨｨ ｨｰ ｨｺ ｨ 05ｨｹ010609ｨｰ020806ｨｪｨｮ, ｨｺｨｰｨｨ09ｨｪ04ｨｬｨｨ 09 01ｨ ｨｪｨｪ06ｨｦ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｨｨｰｨｮｨ 02ｨｨｨｨ. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Heartwire ( article/ do) ｨｰｨ ｨｪ ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ ｨ ｨｪｨｨ07 REVEAL, 09ｨｰｨ ｨｴ ｨｪ06ｨｦ 08ｨ ｨ 06ｨｰ06ｨｦ, 0102ｨｬ06ｨｪ09ｨｰ08ｨｨ08ｨｮ06ｨｴ02ｨｦ ｨｪ0200ｨ ｨｰｨｨ09ｨｪ04ｨｦ ｨｺｨｰ 06ｨｰ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ ｨｨｨｰ ｨｰｨｨｨｪｨ. 01ｨｨ0706ｨｰ020406ｨｦ ｨｨ ｨ ｨｪｨｨ ｨ 00ｨ ｨｹ, ﾂｨｰ06 ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ02 05ｨｰ ｨ 08ｨ ｨｰｨ ﾂ080209ｨｺ0603ｨｪ06ｨｦ ｨ ｨｪ00ｨｨ060705ｨ 09ｨｰｨｨｨｺｨｨ ｨｺ060806ｨｪｨ 08ｨｪ0401 ｨ 08ｨｰ0208ｨｨｨｦ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｲ00ｨｬ06ｨｬ ｨｬ02ｨｪｨｰｨ ST ｨｨｨｰ ｨｮｨｬ02ｨｪｨｹ03ｨｨｨｰｨｹ 08ｨ 04ｨｬ0208 ｨｪ02ｨｺ080604ｨ ｨｮ ﾂ02ｨｪｨｪ ｨ ｨｪｨｪ ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ ｨ 09ｨｪ02ｨｪｨｨｨｨ ｨ 0202ｨ 06 ｨｪｨｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ ｨｦ ｨｪ ｨｨ, ｨｪｨｨ ﾂ ｨｪ ｨｹ ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬ ｨｪ02 ｨｪｨ ｨ ｨ ｨｹ 08ｨ 04ｨｪｨｨ ｨ 04ｨｬ ｨｨｨｪ00ｨ 08ｨｺｨｰｨ ｨｰｨｬ02 ﾂ02ｨｪ06 ｨｰｨ ｨｺ ｨ 0405ｨｨ ﾂｨｨｨｦ ｨｺｨ 04ｨ ｨｰ020507ｨｬ 0802ｨｬ ｨｨ080609ｨ ｨｪｨｨ07 ｨｬｨｨ06ｨｺｨ 0801ｨ ｨｬｨｨｨｬ06 05ｨｰ ｨ 09ｨｰ ﾂ0208ｨｺｨｨ09ｨ 06ｨｰ, ﾂｨｰ06 ｨｪｨ ｨ ｨ 02ｨｰ0907 ｨｰ02ｨｪ0102ｨｪ02ｨｨ07 ｨｺ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ06 08ｨ 04ｨｬ0208ｨ ｨｪ02ｨｺ080604ｨ 0708ｨｨ ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨｨｨ 0508ｨｨｨｰ ｨｰｨｨｨｪｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ 09ｨｰｨ ｨｰ. 06ｨｰ06 ｨｨ ｨ ｨｪｨｨ ｨｰ ｨ 02ｨｰ ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨ ｨ ｨｪｨｪｨｨ01 08ｨ ｨ 06ｨｰ HEBE III ｨｨ REVIVAL-3, ｨｰｨ ｨｺ ｨｬ06ｨｪ09ｨｰ08ｨｨ080609ｨ 0903ｨｨ01 ｨｪ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0508ｨｨｨｰ ｨｰｨｨｨｪｨ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｰ06 ﾂｨｪｨｨｨｺ: Heartwire ( article/ do) ｨｮ05ｨｹｨｰｨ ｨｰ04 03ｨｨ0806ｨｺ06 ｨｨ ｨｰｨｪ ｨｨ ｨ ｨｪｨｨ07 JUPITER 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ02 09ｨｰｨ ｨｰｨｨｨｪ ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ 09 ｨｪ0608ｨｬｨ 05ｨｹｨｪ04ｨｬｨｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07ｨｬｨｨ , ｨｪ ｨｺｨｨｨｬ ｨｮ080609ｨｪ02ｨｬ ｨｪｨｨ03ｨ 02ｨｰ 08ｨｨ09ｨｺ , 08ｨ 0903ｨｨ080707, ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 0706ｨｺｨ 04ｨ ｨｪｨｨ ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 01ｨ ｨｪｨｪ ｨ 08ｨ ｨｰ ｨｺｨｨ 05ｨｰ06ｨｬｨｮ, ｨｪｨｨｨｺ0506 ｨｬｨｪ ｨｪｨ ｨｪ0609ｨｰｨｨ ｨｺｨ - ﾂ0209ｨｰ ｨｨｨｺｨｰ0608ｨ , ｨｹ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 ｨｨ01 ｨ ｨ ｨｰｨｪ ｨｨ09ｨｺｨ 09 ｨｮ0706ｨｬ07ｨｪｨｮｨｰ06ｨｦ 08ｨ ｨ 06ｨｰ02 ｨ ﾂ02ｨｪｨｹ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｬ. 0808ｨｮ07ｨｪ0602 ｨｨ ｨ ｨｪｨｨ02 MESA ｨｰ ｨｰｨ 09ｨｨｨｰ ｨｬｨｪ02ｨｪｨｨ02 01ｨｨｨ 00ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺｨｮ ｨｪｨｪ0609ｨｰｨｹ ｨｨ ｨｨ00ｨ 02ｨｰ ｨｪｨ ｨｬ0209ｨｰ ｨ ｨｪｨｨ02 ｨｺｨ 05ｨｹ02ｨｨ07 09 ｨｺ060806ｨｪｨ 08ｨｪ ｨｮ01ｨ ｨ 09ｨｪ ｨ 08ｨｨｨｰ0205ｨｹｨｪ04ｨｬ ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬ, ｨｨｨｬ02ｨｪｨｪ06 05ｨｰ06ｨｰ 0706ｨｺｨ 04ｨ ｨｰ0205ｨｹ 0905ｨｮ03ｨｨ05 ｨｪｨ ｨｪ04ｨｬ ｨｨｨｺｨｰ060806ｨｬ ｨｪ02ｨｪｨｨｨｦ ｨｰ060806ｨｪ , ｨｰ060001ｨ ｨｺｨ ｨｺ ｨｰｨ ｨｺ060904ｨｬ ｨｪ ｨｰ06 ﾂｨｪｨｨｨｺ: Medscape ( viewarticle/733057) ｨｮ ｨｨ ｨｬ02ｨｪｨｪ06ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ ｨｪｨｰ0002ｨｪ ｨｨ ﾂ0209ｨｺｨｨ02 ｨｬ02ｨｰ ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨｨ 09 ｨｨ ｨｹ040609ｨ ｨｪｨｨ02ｨｬ ｨｺ06ｨｪｨｰ08ｨ 09ｨｰｨｪ ｨ 08ｨ ｨｰ ｨｮ ﾂｨ 06ｨｰ ｨ 0605ｨｹ ｨ ｨｰ08ｨ ｨｪ02ｨｪｨｨ ｨｬ06ｨｰ0807 ｨｪｨ ﾂ0209ｨｨ01ｨｪ ｨｨｨｬｨｮｨｴ0209ｨｰ09ｨ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ ｨｪｨｰ0002ｨｪ06ｨｺ06ｨｪｨｰ08ｨ 09ｨｰｨｪ ｨｰ09, 09 ｨｪｨｨｨｬｨｨ ｨ ｨｪ ｨｹ0004ｨｪ ｨ 06 ﾂｨｪ ｨｺｨｰ0609, 09 ﾂｨ 09ｨｰｨｪ0609ｨｰｨｨ, ｨｺ06ｨｪｨｰ08ｨ 09ｨｰｨｨｨｪ01ｨｮ02ｨｨ080609ｨ ｨｪｨｪｨ 07 ｨｪ ｨ ｨｰｨｨ ｨｹ ｨｨ05ｨ ｨｺｨｰｨｨｨｺｨｨ 09 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ07 ｨｨ ｨｹ04ｨｮ02ｨｰ0907 N-ｨ 0202ｨｰｨｨ0502ｨｨ09ｨｰ02ｨｨｨｪ, 0106ｨｰ07 05ｨｰ06ｨｰ ｨｬ02ｨｰ ｨｰｨ 00ｨｰ ｨｬ02ｨｰ06ｨｬ 01ｨｨ09ｨｺｨｮ0909ｨｨｨｦ ｨｰ06 ﾂｨｺｨｨ ｨｪｨ 01 00i ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨ 08ｨ ｨｰｨ 0708ｨｨ 01ｨ ｨｪｨｪ06ｨｬ ｨｰ0607ｨｪｨｨｨｨ 09ｨｰｨ 0907ｨｰ ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ ｨｨ090704ｨｰｨ ｨｪｨｨ07 ACT ｨ ｨ 02ｨｨ02ｨｪｨｰ0609, 0706ｨｺｨ 04ｨ 0903ｨｨ02, ﾂｨｰ06 ｨｪ02ｨｰ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ06ｨｦ 08ｨ 04ｨｪｨｨ ﾂｨ 09ｨｰ06ｨｰ02 08ｨ 0409ｨｨｨｰｨｨ07 ｨｺ06ｨｪｨｰ08ｨ 09ｨｰｨｨｨｪ01ｨｮ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨｪ ｨ ｨｰｨｨｨｨ ｨｬ020301ｨｮ N-ｨ 0202ｨｰｨｨ0502ｨｨ09ｨｰ02ｨｨｨｪ06ｨｬ ｨｨ 0705ｨ 0202ｨ ｨｰ06 ﾂｨｪｨｨｨｺ: Heartwire ( article/ do) ｨ ｨｨｨ ｨ ｨｰ08ｨ ｨｪ00ｨｪｨｪ06ｨｦ 0708ｨｨ ﾂｨｨｨｪ06ｨｦ 09ｨｬ0208ｨｰｨｨ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609, ｨｮ ﾂｨ 06ｨｴｨｨ ﾂ02ｨｪｨｨ ｨｬ0601ｨｨｨ 05ｨｨ0406ｨｬ ｨｮ , ｨｰ ｨｪ02ｨｪｨｨ ｨｰ060806ｨｪ ｨ ｨｪｨｪ04ｨｬ ｨｪｨｪ FHN, ｨｮ ｨｪｨｨ02 ﾂｨ 09ｨｰ06ｨｰ ｨｬ0601ｨｨｨ 05ｨｨ04ｨ ｨｰｨｨ 08ｨ ｨｪ ｨｰｨｨ09 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ0401 ｨｰ ｨｰ ｨｺ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ06 ｨｬｨ ｨ, ｨｪｨｨ09ｨ ｨｦ ｨｨ 0706ｨｬ06ｨｴｨｨ ｨ 04ｨｪｨｨ02ｨ ｨｰｨ ｨ 13,8 00 (p < 0,001). 0809ｨｰ ｨｨ ｨ ｨｪｨｨ07, 0601ｨｪｨ ｨｺ06, ｨｪ02 04ｨ ｨｰ 06 ｨｰ06ｨｬ, ﾂｨｰ06 ｨｪ0206ｨ ｨｨｨｬ ｨ 02ｨｨ02ｨｪｨｰ ｨｨｨｰｨｹ ｨｪｨ 01ｨ ｨｪｨｪ04ｨｦ ｨｨｨｬ, ｨｺ0605ｨｹｨｺｨｮ 06ｨｪ ｨｪ ｨｬ ｨｨｨｰ ｨｨ ｨｰｨ ｨｰ06 ﾂｨｪ ｨｪ ｨｪ02ｨｪｨｨ ｨｰ06 ﾂｨｪｨｨｨｺ: N Engl J Med 2010;363:2287ｨC ｨｬ02ｨｪｨｪ ｨｰｨ ｨｪｨｨ07 06 ｨ 02ｨｰｨ -ｨ ｨｪ06ｨ 0506ｨｺｨ ｨｰ0608ｨ ｨｪ0604ｨｪｨ ﾂｨｪ06 04ｨ ｨｴｨ 06ｨｰ ｨｨ01 ｨｨ ｨｹ040609ｨ ｨｪｨｨ02 ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ ｨ ｨ ｨ ｨｪｨｨ07ｨｬｨｨ, ｨ 06ｨｴｨｨｨｬｨｨ0907 ｨ 0806ｨｪ010606ｨ 09ｨｰ08ｨｮｨｺ02ｨｨ02ｨｦ, 01ｨ 0302 ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ ｨｪｨ 05ｨｨ ﾂｨｨ ｨｨ05ｨｨ ｨｬ0603ｨｪ06, ﾂｨｰ06 09 ｨ 05ｨｨ03ｨ ｨｦ03ｨｨ02 ｨｪ0209ｨｺ0605ｨｹｨｺ ｨｰ ｨ ｨｪｨ 07 ｨｰ06 ﾂｨｺｨ ｨｪｨｨ07 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｬ06ｨｰ0802ｨｪｨ, ｨｺ0605ｨｹｨｺｨｮ 0802ｨｰ ｨｺｨｰｨｨ09ｨｪ0602 ｨｺ ｨｰｨｪ0602 ｨｨ ｨ ｨｪｨｨ ｨｨ ｨｪｨｨ0302ｨｪｨｨ02 09ｨｬ0208ｨｰｨｪ0609ｨｰｨｨ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ , 0708ｨｨｨｪｨｨｨｬｨ 0903ｨｨ01 ｨ 02ｨｰｨ -ｨ ｨｪ06ｨ 0506ｨｺｨ ｨｰ ｨ 09ｨｪ02ｨｪｨｨｨｨ 09 ｨｰ02ｨｬｨｨ, ｨｺ06ｨｬｨｮ 06ｨｪｨｨ ｨｪ02 ｨｪｨ 04ｨｪｨ ﾂｨ 05ｨｨ09ｨｹ (27,2 ｨｨ 32,3 %, ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06, p < 0,02). 0201ｨｪｨ ｨｺ ｨｮ02ｨｰ ｨｨｨｬ02ｨｰｨｹ 09 09ｨｨ01ｨｮ, ﾂｨｰ06 ｨｨ04-04ｨ 0802ｨｰ ｨｺｨｰｨｨ09ｨｪ ｨｨ04ｨ ｨｦｨｪｨ 09ｨｰ020702ｨｪｨｹ ｨｰ ｨｪ0609ｨｰｨｨ ｨｮ ﾂ02ｨｪｨｪ ｨｮ05ｨｹｨｰｨ ｨｰ0609 ｨｪｨｨ04ｨｺｨ ｨｨ ｨｰ0802ｨ ｨｮ02ｨｰ0907 ｨｨ ｨｰ ｨｪｨｨ ｨｰ06 ﾂｨｪｨｨｨｺ: Arch Int Med 2010;170:880ｨC ｨｺｨｨ 08ｨ ｨｰ08ｨ ｨｪ02ｨｪｨｪ06ｨｬｨｮ ｨｬｨｪ02ｨｪｨｨ06 06 ｨｰ06ｨｬ, ﾂｨｰ06 ｨｨｨｪ00ｨ ｨｨ06ｨｪｨｪ ｨｪ02 06ｨｺｨ ｨ 06ｨｰ 09ｨｨ09ｨｰ02ｨｬｨｪ ｨｦ09ｨｰ09ｨｨ07, 09 ﾂｨ 09ｨｰｨｪ0609ｨｰｨｨ, ｨｪｨ ｨｮ ｨｪ04ｨｦ 06ｨ ｨｬ02ｨｪ, ｨｨｨｬ0206ｨｰ ｨｪｨｨ07 06ｨ 06ｨ 08ｨ ｨｰｨｪ06ｨｬ. 08ｨｪｨ 05ｨｨ04 09ｨｰ08ｨ ｨ ｨ 04 01ｨ ｨｪｨｪ0401, 09ｨｺ0506 ﾂｨ 0903ｨｨｨｦ ｨ ｨｰ ｨ 02ｨｨ02ｨｪｨｰ0609, ｨｺ06ｨｰ060804ｨｬ ｨｪｨ 04ｨｪｨ ﾂｨ 05ｨｨ09ｨｹ ｨｰ0607ｨｨ- ﾂ0209ｨｺｨｨ , ｨｨ05 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 08ｨｨ09ｨｺｨ 0502 ｨｰｨｨ07ｨ ｨｨ ｨｨ01 ｨｨ ｨｹ040609ｨ ｨｪｨｨｨｨ ｨｪｨ 34 % ｨｰ060006, 0708ｨｨ ｨｨ ｨｹ040609ｨ ｨｪｨｨｨｨ ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ ｨ 08ｨ ｨｰ ｨｨ09ｨｺ ｨ 09ｨｰｨ