Tsitologiya 55 (12)

Transcription

1 ｨｬ 55, ｨ, ｨｮ08ｨ 09ｨｺ0609ｨ 06ｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｬ0201ｨｨｨｺ06-ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨ 0502ｨｬ , ｨｺ09ｨ ; ｨｺｨｰ0806ｨｪｨｪ04ｨｦ ｨ : yuliaril@mail.ru ｨ, ｨｮ08ｨ 09ｨｺ0609ｨ ｨｰ0607ｨｪｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ ｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 ｨｬｨｮ05ｨｹｨｰｨｨ0706ｨｰ02ｨｪｨｰｨｪ0401 ｨｬ020402ｨｪ01ｨｨｨｬｨｪ ｨｰ0806ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ( ) ｨ 0506 ｨｺ08ｨ ｨｰｨｺ ｨｬ02ｨｪｨｪ0602 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ ｨｨ CD73 + -ｨｺ0502ｨｰ06ｨｺ ｨｮ050702ｨｨｨｨ, ｨｪ ｨｨ0707 ｨｪｨ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｺ0502ｨｰ06ｨｺ, ｨｪ0209ｨｮｨｴｨｨ01 ｨｪｨ ｨｪ0609ｨｰｨｨ 0108ｨｮ00ｨｨ02 ｨｺ06ｨｪ09ｨｰｨｨｨｰｨｮｨｰｨｨ09ｨｪ0402 ｨｬｨ 08ｨｺ (CD90 ｨｨ CD105). 0308ｨｨ 05ｨｰ06ｨｬ 0002ｨｰ ｨｪｨｪ0609ｨｰｨｹ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｮ050702ｨｨｨｨ 09ｨｪｨｨ03ｨ 05ｨ 09ｨｹ: ｨｨ09 ﾂ0204ｨ 05ｨｨ ｨｺ08ｨｮ07ｨｪ ｨ ｨ 09ｨｰｨ ｨｪｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ ｨ 09ｨｰｨ 05ｨ ｨｨ 09ｨｰｨ ｨ ｨｨ05ｨｹｨｪ ｨ ｨｪ0705ｨ 09ｨｹ 09 ｨｮ ｨｨ0701, 0708ｨｨ ｨｺ06ｨｰ ｨ ｨｪｨｨ02 ｨｺｨｨ ｨ (5 % 02 2 ) ｨ 05ｨｨ04ｨｺ06 ｨｺ ｨｰｨｺｨ ｨｪ020906ｨｬｨｮ ｨｮ080609ｨｪ ｨｨ ｨ ｨｪｨｨ04ｨｺ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ 06ｨｪｨ ｨｰ020702ｨｪｨｪ06 09ｨｪｨｨ03ｨ 05ｨ 09ｨｹ ｨｪｨ ﾂｨｨｨｪｨ ｪ ｨ 0909ｨ 03ｨ ｨ 09ｨｰｨ ｨｪｨｨ ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｪ ｨ ｨｹ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02ｨｬ 05ｨｺ ｨｨｨｨ 0002ｨｪｨ ｨｺｨ ｨｰｨ 05ｨｨｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ0204 ｨｰ020506ｨｬ0208ｨ 0404, ﾂｨｰ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ090609ｨ ｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ 06ｨｪｨｺ060002ｨｪｨｪ06ｨｦ ｨｰ08ｨ ｨｪ ｨｬｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ ｨｪ060002ｨｪ06ｨｬｨｪ04ｨｦ ｨ ｨｪｨ 05ｨｨ04 ｨｮ080609ｨｪ07 05ｨｺ ｨｨｨｨ 0002ｨｪ ｨｨ ｨｰ ｨｪ0602 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ02 05ｨｺ ｨｨｨｨ 0002ｨｪ ｨｨｨｺ05ｨｨｨｪ0609 (CCND2 ｨｨ PCNA), ｨｮ0507ｨｰ0608ｨｪ06ｨｦ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ ｨｨｨｺ05ｨｨｨｪ-04ｨ 09ｨｨ09ｨｨｨｬ0401 ｨｺｨｨｨｪｨ 04 (CKS2) ｨｨ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ 02ｨｨｨｺ05ｨｨｨｪ-04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ ｨｨ6(CDKN2C), ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｦ 02ｨｨｨｺ ｨｨ 09ｨｪｨｨ0302ｨｪｨｨｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ ｨ ﾂ ｨ : ｨｬｨｮ05ｨｹｨｰｨｨ0706ｨｰ02ｨｪｨｰｨｪ0402 ｨｬ020402ｨｪ01ｨｨｨｬｨｪ ｨｰ0806ｨｬｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ, ｨｨｨｬｨｬｨｮｨｪ060002ｨｪ06ｨｰｨｨ07, ｨｬ ｨｨ07, ｨｨ000208ｨ 02ｨｨ ｨｨｨｪ07ｨｰ ｨｺ08ｨ ｨｴ02ｨｪｨｨ07: ｪ ｨｬｨｮ05ｨｹｨｰｨｨ0706ｨｰ02ｨｪｨｰｨｪ0402 ｨｬ020402ｨｪ01ｨｨｨｬｨｪ ｨｰ0806ｨｬｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ. 0604ｨｮ ﾂ02ｨｪｨｨ02 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｪｨｨ03ｨｨ ｨｬｨｮ05ｨｹｨｰｨｨ0706ｨｰ02ｨｪｨｰｨｪ0401 ｨｬ020402ｨｪ01ｨｨｨｬｨｪ ｨｰ0806ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ( ) 0706ｨｺｨ 04ｨ 0506, ﾂｨｰ06 ｨｨ01 ｨｺ06ｨｬ07ｨ 08ｨｰｨｬ02ｨｪｨｰ ｨｰｨｪｨ ｨｰｨ 05ｨｹｨｪ06ｨｬ ｨｨ ｨ ｨｰ08ｨ ｨｪ0702ｨｰ0907 ｨｪｨ ｨｹ ｨ ｨｪｨｨ04ｨｬ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｨ09ｨ 09ｨｺｨｮ050708ｨｪ06ｨｦ 0506ｨｺｨ 05ｨｨ04ｨ 02ｨｨｨｨ (Da Silva Meirelles et al., 2006). 01ｨ ｨｨｨ ｨ 03ｨｪ04ｨｬ 00ｨｨ04ｨｨ ﾂ0209ｨｺｨｨｨｬ 00ｨ ｨｺｨｰ060806ｨｬ ｨｬｨｨｨｺ080606ｨｺ08ｨｮ0302ｨｪｨｨ ｨｰｨｨ01 ｨｰｨｺｨ ｨｪ ｨｪｨｨ03ｨ ｨｰ ｨ 0802ｨｨｨ 05ｨｹｨｪ ｨ ｨｪｨｨ02 ｨｺｨｨ ｨ. 02 ﾂ0209ｨｨ01ｨｪ06, ﾂｨｰ ｨｰ08ｨ ｨｪ09ｨｰ0902ｨｪｨｪ ｨ ｨｪｨｨ02 ｨｬ020402ｨｪ01ｨｨｨｬｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｰ0902ｨｪｨｪｨｨｨｺ ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06 ｨｰ06ｨｺｨ ｨｺ080609ｨｨ, 09ｨｪｨ ｨ 03ｨ 06ｨｴ ｨｨ01 ｨｺｨｨ ｨｬ, 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ ｨｨ01 00ｨｮｨｪｨｺ02ｨｨｨｦ ｨｬ0402 ｨｨ04ｨｬ020802ｨｪｨｨ07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ ｨ 09 08ｨ 0405ｨｨ ﾂｨｪ ｨ ｨｪｨ ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 09 ｨｺ0609ｨｰｨｪ06ｨｬ ｨｬ ｨｨｨｬ0202ｨｰ ｨｬ0209ｨｰ06 00ｨｨ0706ｨｺ09ｨｨ07 ｨｨ ﾂｨｰ06 09 ｨｪ02ｨｺ06ｨｰ ｨ 05ｨ 09ｨｰ ｨ ｨｪｨｨ02 ｨｺｨｨ ｨ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｹｨｪ06 ｨｪｨｨ04ｨｺｨｨｨｬ ( 4 ｪ1 %) (Chow et al., 2000; 0609ｨ ｨｪ0609, 2012) ｨｮ00ｨｨ ｨ ｨｪｨ 01 ｨｨ ｨｰｨｺｨ ｨｪ ｨ ｨｪｨｨ02 ｨｺｨｨ ｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 09ｨ 08ｨｹｨｨ08ｨｮ02ｨｰ: 09 07ｨ 0802ｨｪ01ｨｨｨｬ ｨｺｨｨ01 ｨｨ 09 ｨｺ ｨｰ06ｨｺ02, ｨ ｨｰｨ ｨｺ ｨ 0802ｨｪ01ｨｨｨｬｨｪ ｨ ｨｪｨ 01, ｨｰｨ ｨｺｨｨ01 ｨｺｨ ｨｺ 0702 ﾂ02ｨｪｨｹ, 0706 ﾂｨｺｨｨ ｨｨ , 06ｨｪｨ ｨｰｨ ｨｰ 06ｨｰ % (Jungermann, Kietzmann, 1997; Mik et al., 2004; Wild et al., 2005) ｨｮ00ｨｨ01 ｨｰｨｺｨ ｨｪ ｨ ｨｪｨｨ02 ｨｺｨｨ ｨ 02ｨｴ02 ｨｪｨｨ ｨ ｨｺ, ｨｪ06ｨｬ ｨｬ ｨｪ06 ｨｺ060502ｨ 0502ｨｰ ｨｰ % (Hemphill et al., 2005), ｨｰ ﾂｨ ｨｰｨｺ ｨ 04ｨ ｨｨ 09ｨｰ02ｨｺ050609ｨｨ01ｨｪ06ｨｬ ｨｰ ｪ 06ｨｰ % (Yu, Cringle, 2005). 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨｬ0403ｨｨ, ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ ｨｺｨｮ06 09ｨｰ020702ｨｪｨｹ 09ｨ 09ｨｺｨｮ050708ｨｨ04ｨ 02ｨｨｨｨ, ｨ ｨｪｨｨ02 ｨｺｨｨ ｨ ｨｰｨ ｨｰ 06ｨｺ % (Matsumoto et al., 2005) ｨ ｨｰ0205ｨｹｨｪ06, ｨｨ 09 ｨｨ ｨｨ09ｨ 09ｨｺｨｮ050708ｨｪ06ｨｦ 0506ｨｺｨ 05ｨｨ04ｨ 02ｨｨ02ｨｦ 09 ｨｰｨｺｨ ｨｪ ｨｨ ｨｮ ﾂｨ 09ｨｰｨｨ02ｨｬ ｨ 08ｨ ｨｰｨｨ09ｨｪ ｨ 01 ｨｬ0600ｨｮｨｰ 06ｨｺｨ ｨ ｨｰｨｹ ｨｮ ｨｨ ｨ 0405ｨｨ ﾂｨｪ04ｨｬ 07ｨ 0802ｨｨｨ 05ｨｹｨｪ04ｨｬ 01ｨ ｨｪｨｨ02ｨｬ ｨｺｨｨ ｨ ｨｰ06ｨｬｨｮ, ｨ ｨｮ01ｨｮ ﾂｨｨ ﾂ02ｨｪｨｪ04ｨｬｨｨ 09 08ｨ 0405ｨｨ ﾂｨｪ ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ 07ｨ ｨｰ0600ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｪｨｨ04ｨｬ02, 06ｨｪｨｨ ｨｪ04 06ｨ 05ｨ 01ｨ ｨｰｨｹ ｨｬ0201ｨ ｨｪｨｨ04ｨｬｨ ｨｬｨｨ ｨ ﾂ02ｨｪｨｨ ｨ 09ｨｰｨｨ ﾂｨｪ0609ｨｰｨｨ 0708ｨｨ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｨ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ 09 ｨｬｨｨｨｺ080606ｨｺ08ｨｮ0302ｨｪｨｨｨｨ ｨ 04ｨｦ ｨｨｨｪｨｰ ｨｺ ｨｺｨ ｨｺ ｨｪｨ ｨｨｨ ｨｺｨｰｨｨ09ｨｪ06ｨｬｨｮ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｬｨｮ ｨｬ02ｨｪｨｰｨｮ ｨｰｨｺｨ ｨｪ020906ｨｦ ｨｨｨｪ0302ｨｪ0208ｨｨｨｨ ｨｨ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ04 01ｨｨｨｺｨｰｨｮ02ｨｰ ｨｪ0206ｨ ｨｨｨｬ0609ｨｰｨｹ ｨｪｨｨ07 ｨｨ ｨ ｨｪｨｨｨｦ, ｨｴ02ｨｪｨｪ ｨｪｨｺ02 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｰ0607ｨｪｨｨ ｨｨ01 05ｨｺ0907ｨ ｨｪ09ｨｨｨｨ ex vivo, ｨ ｨｰｨ ｨｺ ｨｰｨｨｨｬｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｹ ｨｨｨ 05ｨｨ0302ｨｪｨｨ07 ｨｺ ｨｮ ｨｨ07ｨｬ 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺ ｨｬｨｨｨｺ080606ｨｺ08ｨｮ0302ｨｪｨｨ07 05ｨｰｨｨ01 ｨｺ0502ｨｰ06ｨｺ ｨｹ06 01ｨ ｨｪｨｪ06ｨｦ 08ｨ ｨ 06ｨｰ ｨｰ ｨｪｨｺｨ 0905ｨｨ07ｨｪｨｨ07 08ｨ 0405ｨｨ ﾂｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ in vitro ｨｪｨ ｨｬ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｰ0607ｨｪｨｨ ｨｺ0502ｨｰ06ｨｺ 03ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ. 00ｨ ｨｰ0208ｨｨｨ 05 ｨｨ ｨｬ02ｨｰ0601ｨｨｨｺｨ ｨｪｨｨ ｨｨ05ｨｨ ｨｨ04 03ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ, ｨｨ ｨｹ04ｨｮ ｨｨ09ｨ ｨｪｨｪｨｮ06 ｨｬ02ｨｰ0601ｨｨｨｺｨｮ (Zuk et al., 2001) 09 ｨｬ0601ｨｨ00ｨｨｨｺｨ 02ｨｨ07ｨｬｨｨ (09ｨｮ08ｨ 09ｨｺ0609ｨ ｨｨ 0108., 2009). 06ｨｺｨ ｨｪｨｹ 06ｨ 08ｨ ｨ ｨ ｨｰ0409ｨ 05ｨｨ 0.075%-ｨｪ04ｨｬ 08ｨ 09ｨｰ ｨｬ ｨｺ060505ｨ 0002ｨｪｨ 0404 IA a

2 ｨｰ0607ｨｪｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ 853 ｨｰ02 ﾂ02ｨｪｨｨ02 35 ｨｬｨｨｨｪ 0708ｨｨ 37 縺05, 04ｨ ｨｰ02ｨｬ 09ｨｮ090702ｨｪ04ｨｨ ｨｪｨｰ08ｨｨ00ｨｮ00ｨｨ080609ｨ 05ｨｨ 2 08ｨ 04ｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 5 ｨｬｨｨｨｪ 0708ｨｨ ｨ /ｨｬｨｨｨｪ, 0609ｨ 0106ｨｺ ｨｮ090702ｨｪ01ｨｨ080609ｨ 05ｨｨ a , ｨ ｨｴ02ｨｦ 10 % 05ｨｬｨ 08ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ ﾂｨｹ02ｨｦ ｨｰｨｺｨｨ, ｨ 05ｨｨ 09 ﾂｨ 03ｨｺｨｨ 0302ｨｰ08ｨｨ ｨｨ 0706ｨｬ02ｨｴｨ 05ｨｨ ｨｨｨｪｨｺｨｮｨ ｨ ｨｰ0608 (5 % , 95 % ｨｮ01ｨ ). 05ｨｬ02ｨｪｨｮ ｨｨ05ｨｨ ﾂ ｨｺｨ ﾂ ｨｰｨｨ0302ｨｪｨｨ ｨｬ06ｨｪ ｨｺ0502ｨｰｨｺｨｨ 07ｨ 0909ｨｨ080609ｨ 05ｨｨ ｨｨ 0706ｨｬ02ｨｴｨ 05ｨｨ 09 ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ, ｨｺ06ｨｰ ｨ 09ｨ 05ｨｨ ｨｨ ｨｹ04ｨｮ07 ｨｬｨｮ05ｨｹｨｰｨｨ00ｨ ｨｦ ｨｨｨｪｨｺｨｮｨ ｨ ｨｰ0608 (Sanyo, ｨｪｨｨ07) ｨｨ05ｨｨ ｨｬ02ｨｰｨｨ ﾂｨｪｨｮ06 ｨｺｨ ｨｬ0208ｨｮ (Stemcell Technologies, ), ｨｬ0601ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪｨｮ06 01ｨ ｨｰ ﾂｨｨｨｺｨ ｨｬｨｨ 01ｨ ｨｪｨｨ07 ｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ ｨ, ｨｨ ｨｮ09ｨ 05ｨｨ 00ｨ ｨｦ 09ｨｬ0209ｨｹ06 (95 % N 2,5% ) 0106 ｨｮ09ｨｰｨ ｨｪ ｨｪｨｨ07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｦ ｨｺｨｨ ｨ 5, 3ｨｨ1% ｨ ｨｪｨ 05ｨｨ04ｨ ｨｪｨ 05ｨｨ ﾂｨｨ ｨｪ0609ｨｰｨｪ0401 ｨｬｨ 08ｨｺ ｨｮ090702ｨｪ04ｨｨ06 ｨｺ0502ｨｰ06ｨｺ ｨｪ0609ｨｨ05ｨｨ ｨ ｨｨ08ｨｺｨｨ (ｨｪ02 ｨｬ02ｨｪ ｨｰ0409. ｨｺ0502ｨｰ06ｨｺ ｨｪｨ ｨ ｨｮ), 0106ｨ ｨ ｨｨ FITC- ｨｨ05ｨｨ PE-ｨｺ06ｨｪｨｲ0600ｨｨ080609ｨ ｨｪｨｪ0402 ｨ ｨｪｨｰｨｨｨｰ0205ｨ 09 08ｨ ｨｪｨｨｨｨ ｨ 09ｨｪ06 ｨｨｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ 00ｨｨ08ｨｬ ｨｨ ｨｨｨｰ (Immunotec, 0808ｨ ｨｪ02ｨｨ07). 06ｨｪｨｺｨｮｨ ｨｨ080609ｨ 05ｨｨ 20 ｨｬｨｨｨｪ 0708ｨｨ 4 縺05 ｨｨ ｨ ｨｪｨ 05ｨｨ04ｨｨ080609ｨ 05ｨｨ ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ06ｨｦ ｨｬ02ｨｰ0601ｨｨｨｺ02 ｨｪｨ ｨｰ06 ﾂｨｪ06ｨｬ 02ｨｨｨｰ060005ｨｮ0608ｨｨｨｬ02ｨｰ0802 Epics XL (Beckman Coulter, ) ｨｪｨｺｨｮ ｨｬ ｨｨ ﾂ0209ｨｺｨｨ01 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺ ｨｨ ｨｨ05ｨｨ 0708ｨｨ ｨ ｨｪｨ 05ｨｨ0402 ｨｬｨｨｨｺ ｨｰ060008ｨ 00ｨｨｨｦ 0905ｨｮ ﾂｨ ｨｦｨｪ ｨ 08ｨ ｨｪｨｪ ｨｦ ｨｪｨｨ07, ｨｮ ﾂ02ｨｪｨｪ ｨｨ ｨｹ040609ｨ ｨｪｨｨ02ｨｬ ｨｰ ｨ ｨｺ06ｨｪｨｰ08ｨ 09ｨｰｨｪ ｨｬｨｨｨｺ080609ｨｺ0607ｨ Leica DM IL (Leica, ｨｬｨ ｨｪｨｨ07) ｨｨ ｨｪｨｪ06ｨｦ 09 ｨｪｨｨｨｬ ｨｰｨｪ06ｨｦ 09ｨｨ010206ｨｺｨ ｨｬ020806ｨｦ (Leica DC500) ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｪｨｨ09ｨ 05ｨｨ, ｨ ｨｪｨ 05ｨｨ04ｨｨ08ｨｮ07 ｨｪ02 ｨｬ02ｨｪ ｨｦ 09 ｨｺｨ ｨｬ 0005ｨ ｨｺ06ｨｪ02 ｨｺｨ ﾂ ｨ 0909ｨｨ080609ｨ ｨｪｨｨ ｨｬ06ｨｴｨｹ ｨ ｨｬｨｬ04 Sigma ScanPro 5.0 Image Analysis Software (SPSS Inc., ) 09 ﾂｨｨｨｰｨ 05ｨｨ ﾂｨｨ ｨｺ0502ｨｰ06ｨｺ ｨｨ 08ｨ 0909 ﾂｨｨｨｰ0409ｨ 05ｨｨ ﾂｨｨ ｨｮ ｨｪｨｨｨｦ ｨｮ050702ｨｨｨｦ (PD) ｨｬｨｮ0502 PD = log 2 N/No, N 0 ｨｨN ｪ ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06 ｨｪｨ ﾂｨ 05ｨｹｨｪ0602 ｨｨ ｨｺ06ｨｪ02 ﾂｨｪ0602 ﾂｨｨ ｨｺ0502ｨｰ06ｨｺ ｨｬ07 ｨｮ ｨｪｨｨ ｨｮ050702ｨｨｨｨ (TD) ｨｨ ｨｬｨｮ0502 TD = (log 2 2)1 7t/[log 2 (N/N 0 )], t ｪ ｨｬ ｨｨ080609ｨｰｨ ｨｮ050702ｨｨｨｨ, N ｪ ﾂｨｨ ｨｺ0502ｨｰ06ｨｺ ﾂ ｨｬ07 t, N 0 ｪ ｨｨ ｨｪ0602 ﾂｨｨ ｨｺ0502ｨｰ06ｨｺ. 08ｨｪｨ 05ｨｨ04 09ｨｰｨ 01ｨｨｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ ｨｨｨｺ05ｨ ｨｨ05ｨｨ ｨｬ02ｨｰ060106ｨｬ ｨｰ06 ﾂｨｪ06ｨｦ 02ｨｨｨｰ060005ｨｮ0608ｨｨｨｬ02ｨｰ08ｨｨｨｨ, ｨｨ ｨｹ04ｨｮ07 ｨｨ0601ｨｨ ｨｨ01ｨｨ07, ｨ 06ｨｴｨｨｨｦ ｨｮ090702ｨｪ04ｨｨ06 ｨｺ0502ｨｰ06ｨｺ ｨｪ0609ｨｨ05ｨｨ ｨ ｨｨ08ｨｺｨｨ (ｨｪ02 ｨｬ02ｨｪ ｨｰ0409. ｨｪｨ ｨ ｨｮ), 0202ｨｪｨｰ08ｨｨ00ｨｮ00ｨｨ080609ｨ 05ｨｨ 5 ｨｬｨｨｨｪ 0708ｨｨ ｨ /ｨｬｨｨｨｪ, ｨｺ 0609ｨ 01ｨｺｨｮ 0106ｨ ｨ ｨｨ 500 ｨｬｨｺ05 70%-ｨｪ ｨｰｨｨ ｨｨ08ｨｰｨ ｨｨ ｨｨｨｪｨｺｨｮｨ ｨｨ080609ｨ 05ｨｨ 1 ﾂ 09 ｨｰ02ｨｬｨｪ06ｨｰ ｨｨ 4 縺05. 05ｨ ｨｰ02ｨｬ ｨｺ0502ｨｰｨｺｨｨ ｨｬ0409ｨ 05ｨｨ ｨ ｨｰｨｪ04ｨｬ ｨ ｨｮ ｨｬ, 0202ｨｪｨｰ08ｨｨ00ｨｮ00ｨｨ080609ｨ 05ｨｨ 5 ｨｬｨｨｨｪ 0708ｨｨ ｨ /ｨｬｨｨｨｪ, ｨｺ 0609ｨ 01ｨｺｨｮ 0106ｨ ｨ ｨｨ 500 ｨｬｨｺ05 08ｨ 09ｨｰ090608ｨ, ｨ ｨｴ ｨｬｨｺ00/ｨｬ05 ｨｨ0601ｨｨ01ｨ ｨｨ01ｨｨ07 ｨｨ 20 ｨｬｨｺ00/ｨｬ ｨ 0404 A, ｨｨｨｪｨｺｨｮｨ ｨｨ080609ｨ 05ｨｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 15 ｨｬｨｨｨｪ 0708ｨｨ ｨｺ06ｨｬｨｪｨ ｨｰｨｪ06ｨｦ ｨｰ02ｨｬ070208ｨ ｨｰｨｮ0802 ｨｨ ｨ ｨｪｨ 05ｨｨ04ｨｨ080609ｨ 05ｨｨ ｨｨ ﾂ0209ｨｰ0906 ｨｺ0502ｨｰ06ｨｺ ｨｪｨｪ06ｨｦ 00ｨ ｨｨｨｺ05ｨ ｨｰ0902ｨｰ09ｨｰ09ｨｮ02ｨｰ ｨ ｨｪｨｨ , ｨｬ06ｨｬｨｮ 0706 ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ0609ｨｰｨｨ 0005ｨｮ ｨｪ02ｨｨｨｨ ｨｺ08ｨ 09ｨｨｨｰ020507, ｨ ｨｪｨｪ ｨ ｨｪｨｨ ｨｮ0109ｨ ｨｨ09ｨ 02ｨｰ ｨ 0402 G 2 /M, ﾂｨｰ06 01ｨ 02ｨｰ 07ｨｨｨｺ 09 ｨ 0605ｨｹ0302ｨｦ ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ0609ｨｰｨｹ ｨｮ ｨｪ02ｨｨｨｨ, ﾂ02ｨｬ 00ｨ 0402 G 1, ｨｰ060001ｨ ｨｺｨ ｨｺ 09 S-00ｨ 0402 ｨｺ0502ｨｰｨｺｨｨ ｨ ｨｰ ｨｬ0203ｨｮｨｰ06 ﾂｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ (09ｨｬ. 08ｨ ｨｮ05ｨｹｨｰｨ ｨｰ0403, 08ｨｨ09. 3, ｨ ) ｨｪｨｨ07 ｨｮ080609ｨｪ07 05ｨｺ ｨｨｨｨ 0002ｨｪｨ ｨｺｨ ｨｰｨ 05ｨｨｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ0204 ｨｰ020506ｨｬ0208ｨ 0404 (htert) ｨｨ04 ｨｺ0502ｨｰ06ｨｺ ｨｨ ｨｬ06ｨｴｨｹ06 TRIZOL ｨ 09ｨｪ06 ｨｨｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ 00ｨｨ08ｨｬ ｨｨ ｨｨｨｰ ｨ ｨｺ02ｨｨ06 06ｨ 08ｨ ｨｰｨｪ06ｨｦ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ ｨｨ ｨｮ ﾂ02ｨｪｨｨ02 ｨｺ ｨｨ ｨｨ05ｨｨ ｨｬ06ｨｴｨｹ06 QuantiTect Reverce Transcription Kit ｨ 09ｨｪ06 ｨｨｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ 00ｨｨ08ｨｬ ｨｨ ｨｨｨｰ (Qiagen, ) ｨｪｨｨ07 ｨｮ080609ｨｪ07 05ｨｺ ｨｨｨｨ 0002ｨｪ ｨｨｨｬ02ｨｪ0705ｨｨ ｨｺ06ｨｬ070502ｨｺｨｰ 0802ｨ 0002ｨｪｨｰ ｨｨｨｬ0208ｨ 04ｨｪ06ｨｦ ｨｪ06ｨｦ 0802ｨ ｨｺ02ｨｨｨｨ, 09 ｨｺ06ｨｰ060804ｨｦ ｨｰ: 09ｨｬ0209ｨｹ ｨｺ09ｨｨ08ｨｨｨ 06ｨｪｨｮｨｺ050206ｨｰｨｨ010609, 0802ｨｺ06ｨｬｨ ｨｨｨｪｨ ｨｪｨｰｨｪｨ ｨｨｨｬ0208ｨ 04ｨ HotStarTaq, MgCl 2 ｨｨ ｨｺ020108, ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｺ06ｨｰ060806ｨｦ ｨｪ06ｨｦ 0802ｨ ｨｺ02ｨｨｨｨ ｨｰｨ ｨｬｨｺ ｨｪｨｺｨｨ ｨｮ080609ｨｪ07 05ｨｺ ｨｨｨｨ 0002ｨｪ0609 ｨｨ ｨｹ040609ｨ 05ｨｨ 07ｨ ｨ ｨｦｨｬ , ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ02 ﾂ02ｨｰ040802ｨｬ ｨｬｨ ｨｬ 0002ｨｪｨ htert ｨｪｨｺｨｮ 01ｨｨ ｨｪ02ｨｨｨ 05ｨｹｨｪ06ｨｦ 05ｨｺ ｨｨｨｨ 0002ｨｪ , ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ ｨｨ ｨ ｨｪｨｨｨｨ ｨｨ 5 %, ｨｨ05ｨｨ ｨｪｨ 2-ｨｬ 07ｨ 0909ｨ ｨｬ06ｨｴｨｹ06 ｨｪｨ ｨ 0608ｨ Human- Ref-8 (Illumina, ) ｨｪｨｨ ｨｨ ｨｹ040609ｨ 05ｨｨ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ04ｨｦ ｨｬ02ｨｰ ｨｬ06ｨｴｨｹ06 TRIZOL ｨ 09ｨｪ06 ｨｨｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ 00ｨｨ08ｨｬ ｨｨ ｨｨｨｰ ｨｮ ﾂ02ｨｪｨｪ ｨ 08ｨ 0402ｨ 01 ｨｺ0502ｨｰ06ｨｺ ｨｨ ｨ ｨｪｨｨ ｨｬ06ｨｴｨｹ06 Nanodrop, ﾂ ｨｪ ｨ ｨｬ0705ｨｨ00ｨｨ02ｨｨ080609ｨ 05ｨｨ ｨｬ06ｨｴｨｹ06 ｨｪｨ ｨ 0608ｨ Illumina(r) TotalPrep6ｾ4 RNA Amplification Kit (Ambion, ). 08ｨｬ0705ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪｨｮ ｨ 05ｨｨ 00ｨｨｨ 08ｨｨ01ｨｨ04ｨ 02ｨｨｨｨ ｨｪｨ ｨｬｨｨｨｺ0806 ﾂｨｨ07ｨ 01 Human-Ref8 gene expression array (Illumina, ) ｨ 09ｨｪ ｨｰ06ｨｺ0605ｨｮ 00ｨｨ08ｨｬ ｨｨ ｨｨｨｰ ﾂ02ｨｰ ｨｨ ｨ ｨｪｨ 05ｨｨ ｨｮ ﾂ02ｨｪｨｪ ｨ ｨｪｨｪ ｨｨ ｨｨ05ｨｨ ｨｬ06ｨｴｨｹ ｨ ｨｬｨｬｨｪ ｨ ﾂ02ｨｪｨｨ07 GenomeStudio software (Illumina, ) 09 ｨｨ ｨｹ040609ｨ ｨｪｨｨ02ｨｬ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ- ﾂ0209ｨｺ ｨｬ0601ｨｮ ｨ ｨｪｨ 05ｨｨ04ｨ 05ｨｺ ｨｨｨｨ 0002ｨｪ ｨ 0405ｨｨ ﾂｨｨ07 09 ﾂｨｨｨｰｨ 05ｨｨ09ｨｹ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ04ｨｬｨｨ 0708ｨｨ P ｨｮ ﾂ02ｨｪｨｨ07 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｺ ｨｨｨｬ02ｨｪｨｰ ｨｪ04 ｨｬｨｨｨｪｨｨｨｬｨｮｨｬ 09 ｨｰ ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ ｨｰ0608ｨ ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ ｨｮ05ｨｹｨｰｨ ｨｰ0609 ｨｨ ｨｹ040609ｨ 05ｨｨ ｨ ｨｬｨｬｨｮ 00Excel WinXP, ｨｰ ｨｪ0609ｨｰｨｹ 08ｨ 0405ｨｨ ﾂｨｨｨｦ ｨｬ020301ｨｮ 0109ｨｮｨｬ ｨｮ0707ｨ ｨｬｨｨ 01ｨ ｨｪｨｪ ｨｪｨｨ09ｨ 05ｨｨ ｨｬ06ｨｴｨｹ06 ｨｪ0207ｨ 08ｨ ｨｬ02ｨｰ08ｨｨ ﾂ0209ｨｺ ｨｺ08ｨｨｨｰ0208ｨｨ07 00ｨ ｨｪｨｪｨ ｪ07ｨｨｨｰｨｪｨｨ 0708ｨｨ 0904ｨ 08ｨ ｨｪｨｪ06ｨｬ ｨｮ080609ｨｪ02 04ｨｪｨ ﾂｨｨｨｬ0609ｨｰｨｨ P ｨ ｨ 06ｨｰ02 ｨｨ ｨｹ040609ｨ 05ｨｨ ｨｮ06ｨｴｨｨ ｨ ｨｺｨｰｨｨ0904: ｨｮ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 a (MP Biomedicals, ), L-0005ｨｮｨｰｨ ｨｬｨｨｨｪ, 08ｨ 09ｨｰ ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ %-ｨｪ06ｨｬ ｨｬ ｨ ｨｮ , ｨ ｨｴ02ｨｬ /ｨｬ ｨｪｨｨ02ｨｨ0505ｨｨｨｪｨ ｨｨ ｨｬｨｺ00/ｨｬ05 09ｨｰ080207ｨｰ06ｨｬｨｨ02ｨｨｨｪｨ (03ｨ ｨｪ06ｨｺ06, ｨｨ07, ｨｨ05ｨｨ 09ｨｨ , ｨｨ07), 05ｨｬｨ 08ｨｨ06ｨｪｨ 05ｨｹｨｪｨｮ06 ｨｰ ﾂｨｹ ｨｰｨｺｨｮ (Hyclone, ), 20 ｨｬ ｨ ｨｰｨｪ04ｨｦ ｨ ｨｮ (09ｨｨ060506ｨｰ, ｨｨ07), 07ｨ 08ｨ ｨｬｨ 05ｨｹ010200ｨｨ01 (Merck, ｨｬｨ ｨｪｨｨ07), 08ｨ 09ｨｰ ｨｰ08ｨｨ0709ｨｨｨｪｨ ｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07ｨｬｨｨ 0902ｨｴ0209ｨｰ ｨｨ / ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06 (Gibco, ｨｨ05ｨｨ Sigma, ), 0.15%-ｨｪ04ｨｦ 08ｨ 09ｨｰ ｨｺ060505ｨ 0002ｨｪｨ 0404 ｨｰｨｨ07ｨ IA (Sigma, ), ｨｬ06ｨｪ06ｨｺ0506ｨｪｨ 05ｨｹｨｪ0402 ｨ ｨｪｨｰｨｨｨｰ0205ｨ ｨｰｨｨ09 ｨ ｨｪｨｰｨｨ0002ｨｪ0609 CD31, CD73, CD90 ｨｨ CD105, ｨｺ06ｨｪｨｲ0600ｨｨ080609ｨ ｨｪｨｪ ｨｮ ｨｨｨｪｨｨ0406ｨｰｨｨ0602ｨｨｨ ｨｪｨ ｨｰ06ｨｬ (FITC) ｨｨ05ｨｨ 00ｨｨｨｺ060508ｨｨｨｰ08ｨｨｨｪ06ｨｬ (PE), ｨｨ ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ02 ｨｨ0406ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨ02 ｨｺ06ｨｪｨｰ080605ｨｨ (Immunotec, 0808ｨ ｨｪ02ｨｨ07) ｨｮ05ｨｹｨｰｨ ｨｰ04 06ｨｬｨｬｨｮｨｪ060002ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｨ05ｨｹ , ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ ｨｮ ｨｨ ｨ 0405ｨｨ ﾂｨｪ ｨ ｨｪ ｨｨ 07 ｨｺ ｨｨ ｨ. 01ｨ ｨｪ0609ｨｰｨｨ ｨｨ ｨｮ02ｨｬ0401 ｨｺ0502ｨｰ06ｨｺ ｨｨ05ｨｨ ｨ ｨｪｨｰｨｨ0002ｨｪ0609, ｨｺ06ｨｰ ｨｮ05ｨｨ08ｨｮ06ｨｰ ｨｰｨ ｨｺｨｨ , ｨｺｨ ｨｺ ｨ ｨｨ07, ｨｬｨｨ0008ｨ 02ｨｨ07, ｨｺ ｨｨ07 ｨｨ ｨ ﾂｨ 09ｨｨ00ｨｪｨ 05ｨ 09ｨｪｨｮｨｰ08ｨｹ ｨｺ0502ｨｰｨｺｨｨ, ｨｨ ｨｬｨｨ08ｨｮ06ｨｰ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04ｨｦ ｨｨｨｬｨｬｨｮｨｪ060002ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｨ05ｨｹ ｨｨ0102ｨｪｨｰｨｪ ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ. 00ｨｨｨｰ060005ｨｮ0608ｨｨｨｬ02ｨｰ08ｨｨ ﾂ0209ｨｺ0602 ｨｨ ｨ ｨｪｨｨ ｨｺｨ 04ｨ 0506, ﾂｨｰ06 01ｨ ｨｪｨｪ04ｨｦ ｨｨ05ｨｹ, ｨｨ ｨｹ04ｨｮ02ｨｬ04ｨｦ 09 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨｨ0102ｨｪｨｰｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ (CD73, CD90 ｨｨ CD105), ｨｪ02 ｨｨ04ｨｬ02ｨｪ ｨｨ 05ｨｰ06ｨｬ ｨｺ0502ｨｰｨｺｨｨ ｨｪ02 ｨｪ020905ｨｨ ｨ ｨｪｨｰｨｨ0002ｨｪｨ CD31, ｨｦ09ｨｰ0902ｨｪｨｪ ｨｪ0106ｨｰ0205ｨｨｨ 05ｨｹｨｪ04ｨｬ ｨｺ0502ｨｰｨｺｨ ｨｬ. 08ｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｨ ｨ ｨｪｨｨｨｨ , 3 ｨｨ05ｨｨ 1 % ｨｪｨ 1-ｨｬ 07ｨ 0909ｨ ｨ ｨｹ 09ｨｪｨｨ0302ｨｪｨｨ02ｨｬ ｨｨ CD73 + -ｨｺ0502ｨｰ06ｨｺ ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ06 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ ｨ

3 ｨ, ｨｮ08ｨ 09ｨｺ0609ｨ ｨ ｨ 05ｨｨ02ｨ ｨｪ0609ｨｰｨｪ0402 ｨｬｨ 08ｨｺ ｪ ｨ 0909ｨ 03ｨ, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ ｨｨ 08ｨ 0405ｨｨ ﾂｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ 03ｨ 0909ｨ 03 00ｨ 08ｨｺ ｨｺ0502ｨｰ06ｨｺ ( %), ｨｪ0209ｨｮｨｴｨｨ01 ｨｬｨ 08ｨｺ , 0708ｨｨ 08ｨ 04ｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ % 5% 3% 1% 1 CD73 CD90 CD ) ) ) ) ) ) ) 5.8ｨ 73.7 ) ) ) 7.6ｨ 82.2 ) ) CD73 CD90 CD ) ) ) ) ) ) ) ) ) ) ) ) 8.7 ｨ ｨｰ ｨｪ ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ 04ｨｪｨ ﾂ02ｨｪｨｨｨｦ 0708ｨｨ 20%-ｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ 022, P , ｨｪ ｨ 07 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｮ00ｨｨ01 ｨｨ ｨｮ02ｨｬ0401 ｨｬｨ 08ｨｺ ｨ 05ｨｹｨｪ02ｨｦ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 ｨｰ ｨ 0909ｨ 0302ｨｦ ｨｪ ｨｨ ｨｪｨ CD105+- ｨｨ CD90+-ｨｺ0502ｨｰ06ｨｺ ｨｨ 0708ｨｨ090601ｨｨ0506 ｨｺ ｨｰｨ ｨｪ ｨｪｨｨ06 ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ CD73+-ｨｺ0502ｨｰ06ｨｺ 0106 ｨｨ ｨｪ ｨｮ080609ｨｪ07 (ｨｰｨ ｨ 05. 1). 0005ｨｨ07ｨｪｨｨ02 08ｨ 0405ｨｨ ﾂｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨｪ ｨ ｨｬ ｨｨ ｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 09 ｨｮ ｨｨ ｨ 0405ｨｨ ﾂｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨｨ ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0402 ｨｬ ｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｮ ｨｨ ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ (20 %) 06ｨｰｨｬ02 ﾂｨ 05ｨｨ ｨｺｨｮ06 09ｨｰ020702ｨｪｨｹ 0002ｨｰ ｨｪｨｪ0609ｨｰｨｨ ｨｮ050702ｨｨｨｦ , ｨｺ06ｨｰ0608ｨ ｨ 03ｨ 05ｨ 09ｨｹ ｨｨ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ 09 ｨｺｨｮ05ｨｹｨｰｨｮ0802 ｨｺ0502ｨｰ06ｨｺ 08ｨ 04ｨｪ0401 ｨｰｨｨ070609, 06ｨｰ05ｨｨ ﾂｨ 06ｨｴｨｨ ｨｬ ｨｨｨｨ ｨｪ06 ｨ ｨｨｨｰｨｹ ｨｰ0802ｨｮ000605ｨｹｨｪ0402 ｨｨ05ｨｨ ﾂｨ ｨｰ0402 ｨｺ0502ｨｰｨｺｨｨ (40 ｪ60 ｨｬｨｺｨｬ), ｨｰ02ｨｪ0609ｨｨ01ｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ (60 ｪ100 ｨｬｨｺｨｬ) ｨｨ 06 ﾂ02ｨｪｨｹ ｨｺ08ｨｮ07ｨｪ0402 ( ｨｬｨｺｨｬ) 09 ｨ 0605ｨｹ03ｨｨｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906ｨｬ 06ｨｰ080609ｨｰｨｺ ｨｨｨｰ0205ｨｹｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 (4 07ｨ 0909ｨ 03ｨ ) ｨ ｨｰ020702ｨｪｨｪ0602 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ ｨｨ ｨｺ08ｨｮ07ｨｪ ｨ ｨ 09ｨｰｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (200 ｨｬｨｺｨｬ ｨｨ ｨ ) ｨｨ 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ ｨｨ ｨｺ0502ｨｰ06ｨｺ ｨｺ05ｨ 0909ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｰ02ｨｪ0609ｨｨ01ｨｪ06ｨｦ ｨｬ04 (60 ｪ 100 ｨｬｨｺｨｬ) (08ｨｨ09. 1, ｨ, ｨ ). 07ｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ ｨ ｨｺ06 2-ｨｬｨｮ 07ｨ 0909ｨ 03ｨｮ 0906ｨｺ08ｨ ｨｴｨ ｨｮ050702ｨｨ06 ｨｺ08ｨｮ07ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｨ ｨ 09ｨｰ090609ｨ ｨ 05ｨ 01ｨ ｨｪｨｨ06 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ ｨ ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (08ｨｨ09. 1, 09, 00, 03). 00 ｨｮ ｨｨ0701 1%-ｨｪ ｨ ｨｪｨｨ ｨｨ09ｨｹ ｨｪ02ｨ 0605ｨｹ03ｨｨ02 ｨｺ0502ｨｰｨｺｨｨ 08ｨ 04ｨｬ020806ｨｬ 40 ｪ60 ｨｬｨｺｨｬ. 02ｨ 05ｨｹｨｪ02ｨｦ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ (3 ｪ4-ｨｦ 07ｨ 0909ｨ 03) 09 ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨ 09ｨｰ090609ｨ ｨ ｨｪｨｨ06 ｨｬ ｨｨ ﾂ0209ｨｺ06ｨｦ 0006ｨｬ060002ｨｪｨｪ0609ｨｰｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｮ050702ｨｨｨｨ. 0308ｨｨ ｨｮ ｨｨ0701, ｨｪｨ ｨｨｨ ｨｨｨ 05ｨｨ0302ｨｪｨｪ0401 ｨｺ ｨｰｨｺｨ ｨｪ020906ｨｬｨｮ ｨｮ080609ｨｪ06 ｨｺｨｨ ｨ (3 ｪ5 %), ｨ ｨｪ0705ｨ 09ｨｹ 0601ｨｪ ｨｪ0609ｨｰｨｹ ｨｺ0502ｨｰ06ｨｺ 09 ｨｺｨｮ05ｨｹｨｰｨｮ0802, ｨｰ060001ｨ ｨｺｨ ｨｺ 0708ｨｨ ｨｺ08ｨ ｨｦｨｪ02 ｨｪｨｨ04ｨｺ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ ｨｪｨ 4-ｨｬ 07ｨ 0909ｨ ｨｨ09ｨｹ 08ｨ ｨ 09ｨｰｨ ｨｪｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 09 ｨ 0605ｨｹ03ｨｨｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906ｨｬ 06ｨｰ080609ｨｰｨｺ0609, 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ ｨｺｨｮ05ｨｹｨｰｨｮ ｨｨ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ. 0005ｨｨ07ｨｪｨｨ02 08ｨ 0405ｨｨ ﾂｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨｪｨ ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 09 ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ ｨｮｨｰ (1-ｨｦ 07ｨ 0909ｨ 03) ｨｪ ｨｨ090601ｨｨ0506 ｨｺ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ. ﾁｨｨ ｨｮ ｨｪｨｨｨｦ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｮ050702ｨｨｨｨ ｨｪ02 ｨｬ02ｨｪ ｨｹ ｨｨ ｨｰ0902ｨｰ09ｨｰ090609ｨ 0506 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ04ｨｬ 04ｨｪｨ - 04ｨｨ ｨｨ ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ 09 ｨｮ ｨｨ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ 20 (ｨ, ｨ ), 5 (09, 00), 3 (01, 02) ｨｨ 1 (03, 04) % ｨｰｨ ｨｪ04 ｨｺ0502ｨｰｨｺｨｨ (ｨ, 09, 01, 03) ｨｨ (ｨ, 00, 02, 04) 07ｨ 0909ｨ 03ｨ ; 00ｨ ｨｦ ｨｺ06ｨｪｨｰ08ｨ 09ｨｰ; ｨｬｨ 0903ｨｰｨ ｨ ｨｪ ｨｰ080204ｨｺｨｨ ｪ 100 ｨｬｨｺｨｬ.

4 ｨｰ0607ｨｪｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ 855 ﾂ02ｨｪｨｨ07ｨｬ 09 ｨｮ ｨｨ ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 (20 % 02 2 ) (08ｨｨ09. 2, ｨ ). 0308ｨｨ 05ｨｰ06ｨｬ ｨｬ07 ｨｮ ｨｪｨｨ ｨｮ050702ｨｨｨｨ ｨｰｨ ｨｺ ｨ 08ｨｹｨｨ080609ｨ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ ｨ 01 06ｨｰ 73 ｪ79 ﾂ 0708ｨｨ 20ｨｨ5% ｪ67 ﾂ 0708ｨｨ 3ｨｨ1%02 2 (ｨｰｨ ｨ 05. 2). 02ｨ 05ｨｹｨｪ02ｨｦ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ ｨ 0909ｨ 03ｨ 06ｨｺｨ ｨ ｨ 09ｨｪ0604ｨｪｨ ﾂｨｪ ｨｰｨｨｨｬｨｮ05ｨｨ08ｨｮ06ｨｴ0202 ｨｺ0502ｨｰ06 ﾂｨｪｨｮ ｨｨ000208ｨ 02ｨｨ ｨｦ09ｨｰ09ｨｨ02 ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ06 06ｨｰ 09ｨｰ020702ｨｪｨｨ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ ｨ ｨｨ ｨ 09ｨｰ090609ｨ ｨｺ08ｨ ｨｴ02ｨｪｨｨ ｨｬ02ｨｪｨｨ ｨｮ ｨｪｨｨ ｨｮ050702ｨｨｨｨ ｪ54 ﾂ. ﾁｨｨ ｨｮ ｨｪｨｨ ｨｮ050702ｨｨｨｨ 09 ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨ 09ｨｰｨ ｨ 04ｨ ｨ 09ｨｪ02ｨｪｨｨ ｨｪｨ ﾂ02ｨｪｨｨ07ｨｬｨｨ ｨｪｨ 1-ｨｬ 07ｨ 0909ｨ ｨ ｨｺｨ ｨｺ 09 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ0401 ｨｮ ｨｨ0701 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｮｨｬ02ｨｪｨｹ03ｨ 05ｨ 09ｨｹ, 06 ﾂ02ｨｬ 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ090609ｨ 05ｨｨ 1.5-ｨｺ08ｨ ｨｰｨｪ ｨｪｨｨ0302ｨｪｨｨ02 ﾂｨｨ0905ｨ ｨｮ ｨｪｨｨ07 ｨｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0602 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ ｨｬ02ｨｪｨｨ ｨｮ ｨｪｨｨ ｨｮ050702ｨｨｨｨ. 0808ｨｨ ｨｨ000208ｨ 02ｨｨｨｨ ｨｪｨ 2-ｨｬ 07ｨ 0909ｨ ｨｨ 1 ｪ5 % ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 06ｨｰ05ｨｨ ﾂｨ 05ｨｨ09ｨｹ 06ｨｰ ｨｺ08ｨｨ0906ｨｦ ｨｨ000208ｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ 09 ｨｺ06ｨｪｨｰ ｨｬ07 05ｨ 00-00ｨ 0404, 09 ｨｰ02 ﾂ02ｨｪｨｨ02 ｨｺ06ｨｰ060806ｨｦ ｨｪ ｨｨ ｨｨ0506 ｨｮ ｨｪｨｨ07 ｨｺ0502ｨｰ06ｨｺ, 0906ｨｺ08ｨ ｨｰｨｨ050609ｨｹ 0106 ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ01 ﾂｨ , ﾂ ｨｪｨ ﾂｨｨｨｪｨ 05ｨ 09ｨｹ 00ｨ 04ｨ ｨ ｨｺｨｰｨｨ09ｨｪ06ｨｦ ｨｨ000208ｨ 02ｨｨｨｨ. 0308ｨｨ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ06ｨｬ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ 05ｨ 00-00ｨ 04ｨ 0105ｨｨ05ｨ 09ｨｹ ｨｪ02 ｨｬ02ｨｪ ｨｮｨｰ ｨｨ 09ｨｬ02ｨｪ0705ｨ 09ｨｹ 00ｨ 0406ｨｦ ｨｬ ｨｪｨｪ ｨｰｨ ｨｺｨｮ05ｨｹｨｰｨｮ0804 (08ｨｨ09. 2, ｨ ) ｨｮ05ｨｹｨｰｨ ｨｰ02 ﾂｨｨ ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ 01, 05ｨｺ090706ｨｪｨｨ080609ｨ ｨｪｨｪ ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ, ｨ ﾂ02ｨｬ ｨ 04ｨ ｨ 0506 ﾂｨｨ ｨｺ0502ｨｰ06ｨｺ 09 ｨｺ06ｨｪｨｰ ｨｬ06ｨｰ0807 ｨｪｨ ｨ 0302ｨｪｨｪ0602 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ02 05ｨ 00-00ｨ ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ, ｨｪ ｨｪ06 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨｰｨｪ060302ｨｪｨｨ07 ｨｺ0502ｨｰ06ｨｺ, ｨｪｨ ｨｴｨｨ ｨｰ06ｨｦ ｨｨ05ｨｨ ｨｨｨｪ06ｨｦ 00ｨ 0402 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｨｨｺ05ｨ (08ｨｨ09. 3, ｨ ) ｨｨ ﾂ0209ｨｰ0906 ｨｺ0502ｨｰ06ｨｺ 09 S-00ｨ 0402 ｨｮ090205ｨｨ ﾂｨｨ09ｨ ｨｹ ｪ6 %, ｨ 09 G 2 /M00ｨ 04ｨ 01 ｪ %. 3-ｨｦ ｨｨ 4-ｨｦ 07ｨ 0909ｨ 03ｨｨ 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ040609ｨ 05ｨｨ09ｨｹ ｨｰ020702ｨｪｨｪ04ｨｬ 09ｨｪｨｨ0302ｨｪｨｨ02ｨｬ ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ06 06ｨｰ ｨ ｨｪｨｨ (08ｨｨ09. 2, ｨ ). 0201ｨｪｨ ｨｺ06 ｨｺ 4-ｨｬｨｮ 07ｨ 0909ｨ 03ｨｮ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 ｨｪｨ ｨｨｨ 0605ｨｹ ﾂｨｨ ｨｮ ｨｪｨｨ07 ｨｨ, ｨ ｨｰ0205ｨｹｨｪ06, ｨｪｨ ｨｨｨｬ02ｨｪｨｹ ｨｬ07 ｨｮ ｨｪｨｨ07 ｨ ｨｮ ｨｺ0502ｨｰ06ｨｺ, 05ｨｺ090706ｨｪｨｨ080609ｨ ｨｪｨｪ ｨｮ ｨｨ0701, 0708ｨｨｨ 05ｨｨ0302ｨｪｨｪ0401 ｨｺ 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨｨｬ, 0708ｨｨ ｨｺ06ｨｰ ｨｮ ｨｪｨｹ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨｰｨ ｨｰ 5 % ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ 01, 05ｨｺ090706ｨｪｨｨ080609ｨ ｨｪｨｪ ｨｨ ｨ ｨｪｨｨ04ｨｺ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 (1 ｨｨ 3 %), ｨｮ090205ｨｨ ﾂｨｨ09ｨ ｨｹ ｨｬ07 ｨｮ ｨｪｨｨ07 ｨｨ 09ｨｪｨｨ03ｨ ｨｹ ﾂｨｨ ｨｮ ｨｪｨｨ ｨｮ050702ｨｨｨｨ ｪ ｨｬ ｨｪ02 ｨｬ02ｨｪ ｨｰｨｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07 04ｨ 6 09ｨｮｨｰ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 09 ｨｰ02 ﾂ02ｨｪｨｨ02 04ｨｨ ｨｨ000208ｨ 02ｨｨ , ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ ｨｨ 08ｨ 0405ｨｨ ﾂｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ. ｨ ｪ ｨｪｨｨ02 04ｨｪｨ ﾂ02ｨｪｨｨ07 ﾂｨｨ0905ｨ ｨｮ ｨｪｨｨ ｨｮ050702ｨｨｨｦ , ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ ｨｨ 20, 5, 3 ｨｨ 1 % O 2 09 ｨｰ02 ﾂ02ｨｪｨｨ02 1 ｪ ｨ 0909ｨ 0302ｨｦ; ｨ ｪ ｨｺ08ｨｨ ｨｨ000208ｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ 09 ｨｰ02 ﾂ02ｨｪｨｨ ｨ 0909ｨ 03ｨ 0708ｨｨ ｨ ｨｪｨｨｨｨ O 2 (%): 20 (ｨｺ08ｨｨ09ｨ 07 1),5(ｨｺ08ｨｨ09ｨ 07 2),3(ｨｺ08ｨｨ09ｨ 07 3)ｨｨ1(ｨｺ08ｨｨ09ｨ 07 4) ﾂｨｺ06ｨｦ 0706ｨｺｨ 04ｨ ｨｪ ｨｰ ｨｪ ｨｰ05ｨｨ ﾂｨｨ07 06ｨｰ 04ｨｪｨ ﾂ02ｨｪｨｨｨｦ ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ ｨ ｨｪｨｨ07 O 2 (20 %), P , n = ｨ 0909ｨ 03ｨ ｨ ﾂ02ｨｬ ｨ 04ｨ ｨ 05ｨｨ ﾂｨｨ ｨｮ ｨｪｨｨｨｦ ｨｮ ﾂｨ 02 20%-ｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨｺ ｨｨ ｨｪｨ ｨｰ020506ｨｬ0208ｨ ｨｮ ｨｨ ｨ 0405ｨｨ ﾂｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ. 01ｨｨ ｨｪ06ｨｬ ｨｨ04 ｨｨ ｨｮ02ｨｬ ｨ 08ｨ ｨｪ02 06ｨ ｨｪｨ 08ｨｮ03ｨｨ05ｨｨ ｨ 0302ｨｪｨｪ06ｨｦ 05ｨｺ ｨｨｨｨ 0002ｨｪｨ htert, ｨｺ0601ｨｨ08ｨｮ06ｨｴ ｨｺｨ ｨｰｨ 05ｨｨ- 06ｨ ｨ 05ｨｨ02ｨ ｨｬ07 ｨｮ ｨｪｨｨ07 ( ﾂ) ｨｮ050702ｨｨｨｨ , ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ ｨｨ 08ｨ 04ｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ, 09 ｨｰ02 ﾂ02ｨｪｨｨ02 1 ｪ ｨ 0909ｨ 0302ｨｦ 03ｨ 0909ｨ ｨ ｨｪｨｨ02 ｨｺｨｨ ｨ, % ｨｦ ｨｦ ｨ ｨ ｨ 3-ｨｦ ｨ ｨ ｨ 4-ｨｦ ｨ ｨ ｨ ｨ ｨｰ ｨｪ ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ 04ｨｪｨ ﾂ02ｨｪｨｨｨｦ 0708ｨｨ 20%-ｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ 02 2 ｨｪｨ ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴ02ｨｬ 07ｨ 0909ｨ 0302, P (n=3).

5 ｨ, ｨｮ08ｨ 09ｨｺ0609ｨ ｨｪｨｨ ｨｪ ｨｬ02ｨｦ09ｨｰ09ｨ Fos (FOSB ｨｨ FOSL1), ｨｺ0601ｨｨ08ｨｮ06ｨｴｨｨ02 ｨ 0205ｨｺｨｨ, ｨｺ06ｨｰ , 01ｨｨｨｬ0208ｨｨ04ｨｮ0709ｨｹ 09 ｨ 0205ｨｺｨ ｨｬｨｨ 0902ｨｬ02ｨｦ09ｨｰ09ｨ Jun, ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ ｨｬｨｨ080609ｨ ｨｪｨｨｨｨ ｨ 0205ｨｺｨ -ｨ ｨｺｨｰｨｨ09ｨ ｨｰ0608ｨ 1 (AP1); 0002ｨｪ04 PCNA ｨｨ CCND2, ｨｮｨｺｨｰ04 ｨｺ06ｨｰ ｨｰｨ ｨｰ 0906ｨ 06ｨｦ 02ｨｨｨｺ05ｨｨｨｪ04, ｨｪ0206ｨ ｨｨｨｬ ｨ ｨｺ0502ｨｰ06ｨｺ ｨｨ04 00ｨ 0404 G 1 09 S-00ｨ 04ｨｮ 09ｨｨｨｪｨｰ0204ｨ , ｨ ｨｰｨ ｨｺ ｨｪ CKS2, ｨｺ0601ｨｨ08ｨｮ06ｨｴｨｨｨｦ ｨｮ0507ｨｰ0608ｨｪｨｮ06 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ02ｨｮ 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ ｨｬ02 ｨｰ060006, 09 06ｨｰ0902ｨｰ ｨｪｨ 0706ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ02 ｨｺｨｨ ｨ ｨｮｨｬ02ｨｪｨｹ03ｨ 05ｨ 09ｨｹ 05ｨｺ ｨｨ07 CDKN2C ｪ 0002ｨｪｨ -ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ ｨ 09ｨｮ030102ｨｪｨｨ02 04ｨｨ ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺｨ 08ｨ ｨｪｨｨ ｨ 04ｨ ｨｬ ｨｺ0502ｨｰ06 ﾂｨｪ ｨｨｨｺ05ｨ 0708ｨｨ 08ｨ 0405ｨｨ ﾂｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ. ｨ ｪ 00ｨｨ09ｨｰ060008ｨ ｨｬｨｬｨ 08ｨ ｨｪｨｨ07 ｨｺ0502ｨｰ06ｨｺ 0706 ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ0609ｨｰｨｨ 0005ｨｮ ｨｪ02ｨｨｨｨ (0608) ｨｨ0601ｨｨ01ｨ ｨｨ01ｨｨ07 (PI), ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴ02ｨｦ ｨ ｨｪｨｨ ; ｨ ｪ ｨｺ0605ｨｨ ﾂ0209ｨｰ0902ｨｪｨｪ ｨｰｨｪ060302ｨｪｨｨ02 PI + -ｨｺ0502ｨｰ06ｨｺ ｨｮ050702ｨｨ ｨ 0909ｨ 03ｨ 09 08ｨ 04ｨｪ ｨ 04ｨ 01 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｨｨｺ05ｨ 0708ｨｨ ｨ ｨｪｨｨｨｨ O 2 20,5ｨｨ1%(n=3). 00ｨｪ ｨｪｨｨ02 ｨｺ0502ｨｰ06 ﾂｨｪ0401 ｨｰ0201ｨｪ ｨｨｨｦ, 0609ｨｪ0609ｨ ｨｪｨｪ0401 ｨｪｨ ｨｨ ｨｹ040609ｨ ｨｪｨｨｨｨ ｨｮｨｪｨｨｨｺｨ 05ｨｹｨｪ ｨｦ09ｨｰ , 09 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｮ ｨ ｨｺｨｰｨｨｨｺｨｮ ｨｰ0907 ｨ ｨｺｨｰｨｮｨ 05ｨｹｨｪ06ｨｦ 04ｨ 01ｨ ﾂ02ｨｦ ｨｬ02ｨｪｨｪ06ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ04 ｨｨ ｨｰ0802ｨ ｨｮ02ｨｰ ｨｪ09ｨｰ090609ｨ ｨｪｨｨ07 ｨｬ02ｨｰ ｨｰ0609ｨｺｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ ｨ 08ｨ ｨｰ ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨｨ ｨｰｨｪ04 ｨｬｨｪ0600ｨｨ02 ｨｬ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ 02ｨｪｨｪ0609ｨｰｨｨ in vitro (Caplan, 1991; Gimble et al., 2007). 0201ｨｪｨ ｨｺ06 09ｨｮｨｴ0209ｨｰ09ｨｮ02ｨｰ ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪ06 05ｨｺ ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ ｨ ｨｪｨｪ ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ ｨｨ07ｨｪｨｨ ｨｰ0209ｨｰ0902ｨｪｨｪ ｨｬｨｨｨｺ080606ｨｺ08ｨｮ0302ｨｪｨｨ07, ｨｺ06ｨｰ ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 06ｨｰ05ｨｨ ﾂｨ 02ｨｰ ｨｰ ｨｮ ｨｨｨｦ, ｨ 09ｨ 02ｨｬ0401 in vitro. 0201ｨｪｨｨｨｬ ｨｨ04 ｨｪｨ ｨｨｨ ｨ 03ｨｪ ｨ ｨｺｨｰ ｨｰ ｨ ｨｦ ｨｰｨ , 07ｨ 08ｨ ｨｬ02ｨｰ0804 ｨｺ06ｨｰ060806ｨｦ ｨｰ08ｨ 01ｨｨ02ｨｨ06ｨｪｨｪ ｨｰｨ 06ｨｰ0907 ｨｪｨ ｨｨｨ ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪ04ｨｬ 0708ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ. 0308ｨｨ 05ｨｰ06ｨｬ ｨｮ ｨｪｨｹ ｨｨｨ 05ｨｨ03ｨ 02ｨｰ0907 ｨｺ ｨｰｨｺｨ ｨｪ020906ｨｬｨｮ (5 %), ｨｰ060001ｨ ｨｺｨ ｨｺ ｨ ｨｪｨｨ02 ｨｺｨｨ ｨ 09 06ｨ 04 ﾂｨｪ ｨｨｨｪｨｺｨｮｨ ｨ ｨｰ0608ｨ ｨｰ0902ｨｰ09ｨｰ09ｨｮ02ｨｰ ｨ ｨｪｨｨ ｨｮ0102 (06ｨｺ %), ﾂｨｰ ｨ 02ｨｰ ｨｮ ｨｪｨｹ 09 ｨｰｨｺｨ ｨｪ020906ｨｬ ｨｬｨｨｨｺ080606ｨｺ08ｨｮ0302ｨｪｨｨｨｨ ｨｨ ｨｬ060302ｨｰ 09ｨｰｨ ｨｰｨｹ 0708ｨｨ ﾂｨｨｨｪ06ｨｦ ｨｬ0603ｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨｦ09ｨｰ ｨｨ 09 05ｨｰｨｨｨｬ ｨｺｨ ｨ 06ｨｰ ｨｪｨｨ07 06 ｨｰ06ｨｬ, ﾂｨｰ06 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺ ｨ ｨｪｨｨ02 ｨｺｨｨ ｨ (3 ｪ7 %) ｨｰ ｨｰｨｨｨｬｨ 05ｨｹｨｪ04ｨｬ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｪｨｨｨｰ0608ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (Fehrer et. al., 2007; 09ｨｮ08ｨ 09ｨｺ0609ｨ ｨｨ 0108., 2009), ｨ ｨ ｨｪｨｨ04ｨｺｨｨｨｦ ｨｮ ｨｪｨｹ ｨｬ060302ｨｰ 06ｨｺｨ 04ｨ ｨｰｨｹ 00ｨｨ0706ｨｺ09ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｺｨｰ ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ ｨｰｨ ｨｺ0302, ﾂｨｰ ｨｨ ｨｪ02ｨｪｨｨ02ｨｬ ｨｪ0208ｨ ｨｰｨｨ09ｨｪ ｨｮｨｪｨｺ02ｨｨｨｦ ｨｪ ｨｺ06 06ｨｺｨ ｨ 06ｨｰ ｨｮ ｨｨ0701 ｨｺ08ｨ ｨｦｨｪ02 ｨｪｨｨ04ｨｺ ｨｰｨｨ ﾂ0209ｨｺｨｮ06 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ02ｨｮ ｨｬ02ｨｪｨｰｨ ｨｰ020506ｨｬ0208ｨ 0404, 09 ｨｮ ｨｨ0701 ｨｺｨ ｨｺ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ (20 % 02 2 ), ｨｰｨ ｨｺ ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ (5 % 02 2 ) ｨｮ080609ｨｪ07 (ｨ 05ｨｨ04ｨｺ ｨｺ 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺ06ｨｬｨｮ) ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ. 0602ｨｬ ｨｪ02 ｨｬ02ｨｪ0202 ｨｪ02ｨ 0605ｨｹ ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｮｨｺｨｰｨ 0102ｨｰ02ｨｺｨｰｨｨ080609ｨ 05ｨｨ ｨｪ06ｨｬ ｨｨ04 06ｨ 08ｨ ｨｺ0502ｨｰ06ｨｺ, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ ｨｨ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ 20 % (08ｨｨ09. 4, ｨ, ｨｺｨ 3), ｨｨ ｨｮ01 06ｨ 08ｨ 0402ｨ 01 ｨｺ0502ｨｰ06ｨｺ, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ ｨｨ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ 5 % (08ｨｨ09. 4, ｨ, ｨｺｨｨ 1 ｨｨ 3), ﾂｨｰ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ 06 ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｬ ｨｮ080609ｨｪ02 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 05ｨｰ ｨｬ02ｨｪｨｰｨ ｨｪｨ 01ｨ ｨｪｨｪ06ｨｬ 05ｨｰｨ 0702 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｪｨｹ 05ｨｺ ｨｨｨｨ 0002ｨｪ0609, ｨｮ06ｨｴｨｨ ｨｨ000208ｨ 02ｨｨ ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨ ｨｪｨ 05ｨｨ ｨｮ05ｨｹｨｰｨ ｨｰ0609, ｨｮ ﾂ02ｨｪｨｪ ｨｨ ｨｪ060002ｨｪ06ｨｬｨｪ06ｨｬ ｨｨ ｨ ｨｪｨｨｨｨ 05ｨｺ ｨｨｨｨ 0002ｨｪ ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ, 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 09 ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ % ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨｨ ｨｨ0506 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 ｨｮ080609ｨｪ07 05ｨｺ ｨｨｨｨ 0002ｨｪ0609, 06ｨｰ0902- ﾂｨ 06ｨｴｨｨ01 04ｨ 0909ｨｰｨｮ070502ｨｪｨｨ02 ｨｺ0502ｨｰ06ｨｺ 09 ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｦ 02ｨｨｨｺ05 ｨｨ ｨｨｨｰｨｨ09ｨｪ ｨｮ05ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｨ ｨｨ000208ｨ 02ｨｨ06 (ｨｰｨ ｨ 05. 3) ｨｨ 04ｨｨ ｨｪｨ 05ｨｨ04 05ｨｺ ｨｨｨｨ 0002ｨｪｨ, ｨｺ0601ｨｨ08ｨｮ06ｨｴ ｨｪ ｨ ｨｦ09ｨｨ080609ｨ ｨｪｨｪｨｮ06 ｨｨ ｨｬｨｮ ｨｺｨ ｨｰｨ 05ｨｨｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ0204 ｨｰ020506ｨｬ0208ｨ 0404 (htert) 09 ｨｰ02 ﾂ02ｨｪｨｨ ｨｨｨｺ ｨｮｨｺｨｰ ｨ ｨｬ0705ｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ ( ｨｪ.) 09ｨｨ0102ｨｪ 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ ｨ 08ｨ 0402ｨ 01 05ｨｨｨｪｨｨｨｦ 0607ｨｮ ｨｺ0502ｨｰ06ｨｺ HeLa, SiHa 09 06ｨ 08ｨ 0402ｨ ｨ 0909ｨ 03ｨ, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ ｨｨ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ 20 (ｨ ) ｨｨ5(ｨ ) %.

6 ｨｰ0607ｨｪｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ ｨｬ02ｨｪ02ｨｪｨｨ02 ｨｮ080609ｨｪ07 05ｨｺ ｨｨｨｨ 0002ｨｪ0609, ｨ ｨｨｨｨ080609ｨ ｨｪｨｪ ｨｨ000208ｨ 02ｨｨ02ｨｦ , 0708ｨｨ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨｨｨ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ 06ｨｰ % 06ｨ ｨ 05ｨｨ02ｨ ｨｺｨ ｨｪｨ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 09 ｨ ｨ 04ｨ 01 01ｨ ｨｪｨｪ0401 (RefSeq) 05ｨｨｨｬ ｨｪｨ 01ｨ 0409ｨ ｨｪｨｨ ｨｮｨｺｨｰｨ 06ｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ0609ｨｰｨｹ 09ｨｨ00ｨｪｨ 05ｨ ｨｪｨ ｨｬｨｨｨｺ0806 ﾂｨｨ0702, 06ｨｰｨｪ % % ｨｰｨｪ060302ｨｪｨｨ02 09ｨｨ00ｨｪｨ NM_ FOSB ｨｺｨｨ 0902ｨｬ02ｨｦ09ｨｰ09ｨ fos, ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ ｨｬｨｨ080609ｨ ｨｪｨｨｨｨ ｨ NM_ FOSL1 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ ｨ ｨｺｨｰ0608ｨ AP ｨ NM_ PCNA ｨｪ04ｨｦ ｨ ｨｪｨｰｨｨ0002ｨｪ ｨｨ000208ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ06ｨｺ ｨ NM_ CCND2 G 1 /S ｨｨ00ｨｨ ﾂｨｪ04ｨｦ 02ｨｨｨｺ05ｨｨｨｪ D ｨ NM_ CKS ｨｮ0507ｨｰ0608ｨｪｨ 07 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ02ｨ 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ ｨ NM_ CDKN2C 06ｨｪ00ｨｨｨ ｨｨｨｰ ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ ｨ ｨ ｨｰ ｨｪ ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ 04ｨｪｨ ﾂ02ｨｪｨｨｨｦ 0708ｨｨ 20%-ｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ 02 2, P ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ, ｨｺ06ｨｰ ｨｨｨｬ0202ｨｰ ｨｬ0209ｨｰ ｨｨ 07ｨ ｨｰ ｨｨ ﾂ0209ｨｺｨｨ ｨ 01 ｨｨ05ｨｨ ｨｪｨｨｨｨ ｨｰｨｺｨ ｨｪ02ｨｦ ｨｨ 09 05ｨｰｨｨｨｬ ｨｨｨｪｨｨｨｬｨ 06ｨｰ ｨｰｨｺｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨ ｨｰ0607ｨｪｨｨ07 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 ｨｺ0502ｨｰ06ｨｺ 0708ｨｨ 08ｨ 0405ｨｨ ﾂｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ (09ｨｮ08ｨ 09ｨｺ0609ｨ, 08ｨｪ0601ｨｨｨｪｨ, 2007; Fehrer et al., 2007; 09ｨｮ08ｨ 09ｨｺ0609ｨ ｨｨ 0108., 2009; Dos Santos et al., 2010; Lavrentieva et al., 2010; Basciano et al., 2011) ｨ ｨｨｨｬ04ｨｬ 07ｨ 08ｨ ｨｬ02ｨｰ0806ｨｬ 09 ｨｨ0102ｨｪｨｰｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ ｨｪｨｪ0401 ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 ｨｺ0502ｨｰ06ｨｺ ｨｰ ｨｪｨｨ02 ｨｨ ｨｰ ｨｪｨｨ02 09ｨｰｨ ｨｰｨｮ09ｨ ｨｬ020402ｨｪ01ｨｨｨｬｨｪ ｨｰ0806ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨ 0502ｨｪｨｨ06, 09 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ07 ｨｪ ｨｰｨ ｨｰ ｨｬ0603ｨｪ04ｨｬ ｨｪｨｨ ｨｪ ｨｨ05ｨｨ ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ ｨｪｨｪ ｨｪ0609ｨｰｨｪ0401 ｨｬｨ 08ｨｺ , ｨｺ06ｨｰ ｨｨ05ｨｨ ｨ 04 ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ080609ｨ ｨｰｨｹ ｨ 0405ｨｨ ﾂｨｪ ｨｨｨｰ0208ｨ ｨｰｨｮ08ｨｪ0402 ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺｨｨ 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｰ ｨｰｨ ｨｰ06 ﾂｨｪ06 ｨ 0605ｨｹ0306ｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ0902 ｨ ｨｪｨｰｨｨ0002ｨｪ0609, ｨｺ06ｨｰ ｨｬ0600ｨｮｨｰ ｨ 04ｨｰｨｹ 09 08ｨ 04ｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ 05ｨｺ ｨｨ080609ｨ ｨｪ04 ｨｪｨ ｨｪ0609ｨｰｨｨ ｨ 0405ｨｨ ﾂｨｪ ｨｨ ｨｪｨｨ07, 09 ｨｰ06ｨｬ ﾂｨｨ ｨｨ 03ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ (Gronthos et al., 2001; Gimble et al., 2007; 05ｨ ｨｬ06ｨｦ050609ｨｨ ﾂ ｨｨ 0108., 2013). 00 ｨｪｨ 0302ｨｬ ｨｨ ｨ ｨｪｨｨｨｨ 09 ｨｮ ｨｨ ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨｰｨ ｨ ｨｨ05ｨｹｨｪ06 05ｨｺ ｨｨ080609ｨ 05ｨｨ ｨｰｨ ｨｺｨｨ ｨｪ0609ｨｰｨｪ0402 ｨｬｨ 08ｨｺ020804, ｨｺｨ ｨｺ CD105 (05ｨｪ ｨｨｨｪ), CD90 ( ｨｰ0608ｨｪｨ 07 ｨｰｨｨ080604ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ -1) ｨｨ CD73 (5R-ｨｪｨｮｨｺ050206ｨｰｨｨ01ｨ 04ｨ ), ｨｬｨｨ08ｨｮ07 ｨｰ02ｨｬ 09ｨ ｨｬ04ｨｬ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04ｨｦ ｨｨｨｬｨｬｨｮｨｪ060002ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｨ05ｨｹ. 05ｨｪｨｨ0302ｨｪｨｨ ｨｨ CD73 + -ｨｺ0502ｨｰ06ｨｺ 0708ｨｨ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ ｨ ｨ ｨｰ08ｨ ｨｪ04ｨｨｨｰ0608ｨｪ04ｨｬ, ｨｨ 09 01ｨ 05ｨｹｨｪ02ｨｦ0302ｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｰｨｨ01 ｨｺ0502ｨｰ06ｨｺ ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ ｨｹ 0106 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ ｨｮ080609ｨｪ ｨｰｨｪ06, ﾂｨｰ06 CD ｨｰｨ ｨｰ 0906ｨ 06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ ｨ ｨｪｨｪ04ｨｦ ｨｬ02ｨｪｨｰ, ｨｺ06ｨｰ060804ｨｦ 0708ｨｨｨｪｨｨｨｬｨ 02ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0602 ｨｮ ﾂｨ 09ｨｰｨｨ02 09 ｨｺｨ ｨｰｨ ｨ 0605ｨｨ04ｨｬ02 07ｨｮ08ｨｨｨｪ0609 ｨｨ 07ｨｨ08ｨｨｨｬｨｨ01ｨｨｨｪ0609, ｨｺｨ ｨｰｨ 05ｨｨ04ｨｨ08ｨｮ02ｨｰ ｨ ｨｴ02ｨｪｨｨ ｨ 0102ｨｪ0604ｨｨｨｪｨ ｨｨ 04ｨ 09ｨｨ09ｨｨｨｰ 06ｨｰ ｨｮ080609ｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ (Ledoux et al., 2003). 0308ｨｨ ｨｨ ｨ ｨｪｨｨｨｨ 08ｨ ｨ 06ｨｰ04 05ｨｰ ｨｬ02ｨｪｨｰｨ 09 ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｮ080609ｨｪ07 ｨｪｨ ｨｪ0609ｨｰｨｨ 09 ｨｮ ｨｨ ｨｨ0706ｨｺ09ｨｨｨｨ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨ ｨｪ06 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ02ｨｦ 08ｨ 0405ｨｨ ﾂｨｪ0401 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ ｨ ｨｺｨｰ , 09 ｨｰ06ｨｬ ﾂｨｨ HIF-1 (Synnestvedt et al., 2002). 01ｨ ｨ ｨ 02ｨｬ ｨｪｨ 0302ｨｦ 08ｨ ｨ 06ｨｰ02 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ02 ｨｬ ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ 09 ｨｮ ｨｨ ｨｨ0706ｨｺ09ｨｨｨｨ ｨ ｨｰｨｬ02 ﾂ02ｨｪ06 ｨｨ 09 06ｨｰｨｪ060302ｨｪｨｨｨｨ ｨｺ0609ｨｰｨｪ ｨｬ060400ｨ ﾂ ｨｺｨ : 48- ﾂｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 ｨｺ0502ｨｰ06ｨｺ 09 ｨｮ ｨｨ0701 1%-ｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ 0708ｨｨ090601ｨｨ0506 ｨｺ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ06 ｨｨ01 08ｨ 04ｨｬ , ｨｺ0806ｨｬ02 ｨｰ060006, ｨｺ0502ｨｰｨｺｨｨ 0708ｨｨ06ｨ 0802ｨｰｨ 05ｨｨ ｨ ｨｰ07ｨｪｨｮｨｰｨｮ ｨｬｨｮ (Raheja et al., 2011). 01ｨ ｨｺ ｨｪｨｨ02 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 09ｨｨ05ｨｹｨｪ06 08ｨ ｨ 09ｨｰｨ ｨｪｨｪ0401 ｨｪ ｨｨ000208ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ06ｨｺ ｨ 0605ｨｹ ｨ 04ｨｬ0208ｨ ｨｨ ｨ ｨｰ0205ｨｨ ｨ 06ｨｰ ｨｰｨ 0802ｨｪｨｨ02ｨｬ ｨｮ050702ｨｨｨｨ, 06 ﾂ02ｨｬ 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪｨ 07 05ｨｺ ｨｨ07 b-00ｨ 05ｨ ｨｺｨｰ0604ｨｨ01ｨ ｨｰｨｨ01 ｨｺ0502ｨｰｨｺｨ 01 (Safwani et al., 2012). 05ｨｪｨｨ0302ｨｪｨｨ ｨｨ ｨｺ08ｨｮ07ｨｪ ｨ ｨ 09ｨｰｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 09 ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨｰ ｨｨｨｰｨｹ, ﾂｨｰ06 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪｨ 07 00ｨｨ ｨｺ09ｨｨ07 ｨｬ060302ｨｰ ｨｰｨｹ ｨ ｨｺｨｰ060806ｨｬ, ｨｨ08ｨｮ06ｨｴｨｨｨｬ ｨｪｨｨ02 ｨｰｨ ｨｺｨｨ01 ｨｺ0502ｨｰ06ｨｺ 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ ｨｮ09ｨｺｨ 07, ﾂｨｰ06 05ｨｰ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ 06ｨ ｨｨ ｨｪｨｨｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07, ｨｬ0603ｨｪ ｨｨｨｰｨｹ, ﾂｨｰ ｨｨｨ 05ｨｨ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ ｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 ｨｺ ｨｰｨｺｨ ｨｪ020906ｨｬｨｮ ｨｮ080609ｨｪ06 06ｨ ﾂｨｨ09ｨ 02ｨｰ 09ｨｪｨｨ0302ｨｪｨｨ02 09ｨｰ020702ｨｪｨｨ 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ ｨｰ ｨ ｨｨ 0002ｨｰ ｨｪｨｪ0609ｨｰｨｨ ｨｺｨｮ05ｨｹｨｰｨｮ ｨｪｨ ｨｺ06 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｨ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ 1 %, ｨｰｨｪ06 06ｨｺｨ ｨ ｨ 06ｨｴ ｨｦ09ｨｰ09ｨｨ02, 09ｨｪ0609ｨｹ 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ ｨｰ ｨｪｨｪ0609ｨｰｨｨ ｨｺｨｮ05ｨｹｨｰｨｮ0804, ﾂｨｰ ｨｰ ｨｪｨｨｨｨ 09ｨｨ05ｨｹｨｪ06 08ｨ ｨ 09ｨｰｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｺ 4-ｨｬｨｮ 07ｨ 0909ｨ 03ｨｮ ｨｰｨ ｨｪｨｪ ｨ ｨｪｨｪ ｨｨ07ｨｪｨｨｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨｪｨ ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨ 09ｨｮ06ｨｰ ｨｬ ｨｨ ｨ ｨｪｨｨｨｦ, 0102ｨｬ06ｨｪ09ｨｰ08ｨｨ08ｨｮ06ｨｴｨｨ ｨｬ0603ｨｪ0609ｨｰｨｹ 09ｨｰｨｨｨｬｨｮ050702ｨｨｨｨ ｨｨ000208ｨ 02ｨｨｨｨ ｨｪ0201ｨｨ ｨｪ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｨ04 08ｨ 0405ｨｨ ﾂｨｪ0401 ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺ ｨｨ 09ｨｪｨｨ0302ｨｪｨｨｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ02ｨｦ ｨｺｨｨ ｨ. 06ｨ ｨｺ, 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ ｨｮｨｰ06 ﾂｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｺ0609ｨｰｨｪ ｨｬ060400ｨ ﾂ ｨｺｨ ｨｪｨ 08ｨ ｨｪｨｪｨｨ01 07ｨ 0909ｨ 03ｨ ｨｨ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ 2 % ｨ ｨｹ ｨ 0605ｨｹ03ｨｨｨｬ 0708ｨｨ080609ｨｰ06ｨｬ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｮ050702ｨｨｨｨ, 0708ｨｨ 05ｨｰ06ｨｬ ｨｰｨ ｨｺ ｨｰｨｬ02 ﾂｨ 05ｨｨ 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ02 05ｨ 00-00ｨ ｨ 09ｨｪ02ｨｪｨｨ06 09 ｨｰｨ ｨｺ060906ｨｦ 0708ｨｨ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ 20 % (Dos Santos et al., 2010) ｨ ｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 ｨｪｨ ｨ ｨ 05ｨｨ ｨｨ 0708ｨｨ 0105ｨｨｨｰ0205ｨｹｨｪ06ｨｬ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ 09 ｨｮ ｨｨ0701 3%-ｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ (Fehrer et al., 2007) ｨ 09ｨｰｨ 06ｨｴｨｨｨｦ ｨｨ000208ｨ ｨｰｨｨ09ｨｪ04ｨｦ 0706ｨｰ02ｨｪ02ｨｨｨ 05 06ｨｰｨｬ02 ﾂ02ｨｪ ｨｮ070609ｨｨｨｪ04 09 ｨｮ ｨｨ ｨ 0405ｨｨ ﾂｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ﾂ ﾂ 09 ｨｮ ｨｨ ｨｨ 2.5 % ｨｨ000208ｨ 02ｨｨ07 ｨｮ090205ｨｨ ﾂｨｨ09ｨ 05ｨ 09ｨｹ, 0601ｨｪｨ ｨｺ ｨｨ 1.5%-ｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ 02 2, ｨｪｨ 06ｨ ｨｰ, ｨｪ0209ｨｺ0605ｨｹｨｺ06 09ｨｪｨｨ03ｨ 05ｨ 09ｨｹ (Lavrentieva et al., 2010). 0508ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨ ｨｪｨ 05ｨｨ ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ , ｨｪｨｪ0401 ｨｨ04 07ｨｮ05ｨｹ ｨｮｨ ｨ, 0708ｨｨ 08ｨ 0405ｨｨ ﾂｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ (1, 3, 10 ｨｨ 20 %) 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 ｨｪｨ ｨｪｨ ﾂｨ 05ｨｹｨｪ ｨｰｨ 07ｨ 01 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 (4 09ｨｮｨｰ) ｨｪｨ ｨｨｨ 0605ｨｹ0302ｨｦ 09ｨｺ ｨｰｨｹ ｨｨ000208ｨ 02ｨｨｨｨ 06ｨ 05ｨ 01ｨ 05ｨｨ ｨｺ0502ｨｰｨｺｨｨ 09 ｨｮ ｨｨ0701 3%-ｨｪ ｨ ｨｪｨｨ , ｨｰ060001ｨ ｨｺｨ ｨｺ ｨｮ00ｨｨ ｨｮ- ﾂｨ ｨｺ ｨｰｨｹ ｨｨ000208ｨ 02ｨｨｨｨ ｨ 0405ｨ 0906ｨｨ04ｨｬ0208ｨｨｨｬ06ｨｦ ｨｨｨｰ0205ｨｹｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｨ090601ｨｨ0506 ｨｺ ｨ 09ｨｪｨｨ09ｨ ｨｪｨｨ06

7 ｨ, ｨｮ08ｨ 09ｨｺ0609ｨ 05ｨｰ ｨｺｨ 04ｨ ｨｰ ｨｨ ｨｨ ｨｮ02ｨｬ0401 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ0701 ｨｺｨｨ ｨ (Iida et al., 2010) ｨｰｨｪ06, ﾂｨｰ06 09 ｨｺ06ｨｪｨｰ ｨ ｨｨ000208ｨ 02ｨｨ02ｨｦ ｨｺ0502ｨｰｨｺｨｨ 09ｨ 03ｨｪｨｮ ｨｹ ｨｨ0008ｨ 02ｨｰ ｨｰ020506ｨｬ0208ｨ 04ｨ ｪ ｨｬ02ｨｪｨｰ, ｨｰ08ｨ ｨｨ09ｨ 06ｨｴｨｨｨｦ ｨｰ020506ｨｬ0208ｨｪ ｨｰ ｨｺ0502ｨｰｨｺｨ 01 08ｨ 0405ｨｨ ﾂｨｪ0401 ｨｰｨｨ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｰ020506ｨｬ0208ｨ ｨｰ ｨｮ05ｨｨ08ｨｮ02ｨｰ ｨｨ ｨ ｨｪｨｨｨｦ 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｰ020506ｨｬ0208ｨ ｨ ｨｪｨ 09 ｨｰ08ｨ ｨｪ ｨｬｨ 02ｨｨ02ｨｦ ｨｺ0502ｨｰ06ｨｺ, 0708ｨｨ06ｨ 0802ｨｰｨ 06ｨｴｨｨ ｨｰ02ｨｪ02ｨｨｨ 05 ｨｺ ｨｪ ｨ ｨｪｨｨ ﾂ02ｨｪｨｪ06ｨｬｨｮ ｨｪｨｨ ｨｪｨ ｨｺ06 ｨｪｨ 05ｨｨ ﾂｨｨ02 ｨ ｨｺｨｰｨｨ09ｨｪ06ｨｦ ｨｰ020506ｨｬ0208ｨ ｨｺｨ 04ｨ ｨｪ06 ｨｨ 09 09ｨｰ ｨｺ0502ｨｰｨｺｨ ｨ ｨｪｨｨ04ｨｬｨ ( ｨ ｨｨ 0108., 2010) ｨｮ ﾂ02ｨｪｨｪ0402 ｨｪｨ ｨｬｨｨ 01ｨ ｨｪｨｪ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｰ 06 ｨｰ06ｨｬ, ﾂｨｰ06 ｨｬ020402ｨｪ01ｨｨｨｬｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 09ｨｰ0806ｨｬ ｨ ｨｪｨｨ04ｨｬｨ 06ｨ 05ｨ 01ｨ 06ｨｰ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｬ ｨｮ080609ｨｪ02ｨｬ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 05ｨｰ ｨｬ02ｨｪｨｰｨ, ｨｺ06ｨｰ0608ｨ 07 ｨｪ ｨ 09ｨｰｨ 02ｨｰ 0708ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ 09 ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ, ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ ｨ 09ｨｰｨ ｨｪｨｨ ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ. 05ｨｪｨｨ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ ｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ % ｨｪ ｨｨ090601ｨｨｨｰ ｨｺ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｰ020506ｨｬ0208ｨ 0404, ｨｨ 05ｨｰ ｨｰ ｨｨｨｰｨｹ, ﾂｨｰ06 ｨ 0605ｨｹ03ｨ ｨ 09ｨｪ02ｨｪｨｨ ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ04ｨｬｨｨ ｨｮ ｨｨ07ｨｬｨｨ (20 % 02 2 ) ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｪ ｨｰ ｨｮ05ｨｹｨｰｨ ｨｰ06ｨｬ ｨｨ01 ｨｰ08ｨ ｨｪ ｨｬｨ 02ｨｨｨｨ. 02ｨ ｨｪｨｪ0602 ｨｪｨ ｨ ｨｪｨｨ ｨ 09ｨｮ02ｨｰ ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬｨｨ 0108ｨｮ0006ｨｦ 0008ｨｮ ｨｨ ｨ ｨｰ020502ｨｦ, 0706ｨｺｨ 04ｨ 0903ｨｨ01, ﾂｨｰ06 09 ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨｺ0609ｨｰｨｪ ｨｬ060400ｨ, ｨ 07 ｨ 0605ｨｹ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｮ ｨｪｨｨｨｦ, ｨｨｨｬ0206ｨｰ ｨｬ02ｨｪｨｹ03ｨｮ ｨｨｨｪｨｮ ｨｰ020506ｨｬ0208, ﾂ02ｨｬ 09 ｨｮ ｨｨ ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 (Dos Santos et al., 2010). 0806ｨｬ070502ｨｺ09ｨｪ0602 ｨｨ04ｨｮ ﾂ02ｨｪｨｨ ｨｨ ｨｺ ｨｨｨｨ 0002ｨｪ , ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ ｨｨ 20 ｨｨ 5 % 02 2, ｨｨ ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 ｨｮ080609ｨｪ07 05ｨｺ ｨｨｨｨ 06ｨｰ010205ｨｹｨｪ ｨｪ0609, 0708ｨｨｨｪｨｨｨｬｨ 06ｨｴｨｨ01 ｨｮ ﾂｨ 09ｨｰｨｨ ｨ ｨｬ ｨ 0405ｨｨ ﾂｨｪ ｨｪｨｮｨｰ08ｨｨｨｺ0502ｨｰ06 ﾂｨｪ ｨ 01, 09 ｨｰ06ｨｬ ﾂｨｨ ｨｨ 0002ｨｪ0609, ｨｮｨｺｨｰ04 ｨｺ06ｨｰ ｨｨｨｪｨｨｨｬｨ 06ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0602 ｨｮ ﾂｨ 09ｨｰｨｨ ｨｮ050702ｨｨｨｨ ｨｪｨｨ07 ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ ｨｨｨｺ05ｨ. 06ｨ ｨｺ, 05ｨｺ ｨｨ07 FOSB, FOSL1 ｨｨ CCND2 ｨｬ060302ｨｰ ｨｺ ｨｪｨｪ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ090609ｨ ｨｰｨｹ 06ｨ ｨｮ ﾂｨ 09ｨｰｨｨｨｨ AP-1 09 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｨ000208ｨ 02ｨｨｨｨ ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ. 0608ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ04ｨｦ 00ｨ ｨｺｨｰ0608 AP ｨｮ05ｨｨ08ｨｮ02ｨｰ 05ｨｺ ｨｨ ｨ 0002ｨｪ ｨｰ0902ｨｰ ｨｪｨ 08ｨ 0405ｨｨ ﾂｨｪ ｨｰｨｨｨｬｨｮ0504, 09ｨｺ0506 ﾂｨ 07 02ｨｨｨｰ06ｨｺｨｨｨｪ04, 00ｨ ｨｺｨｰ ｨｰｨ ｨｨ 09ｨｰ (Puntschart et al., 1998) ｨｬ02 ｨｰ060006, ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 05ｨｺ ｨｨｨｨ 0002ｨｪｨ 02ｨｨｨｺ05ｨｨｨｪｨ D (CCND2) ｨ ｨｨｨｨ080609ｨ ｨｪｨ ｨｬ ｨｺ0502ｨｰ06ｨｺ ｨｨ04 00ｨ 0404 G ｨ 04ｨｮ S 02ｨｨｨｺ05ｨ ｨｨ ｨｬ060005ｨ ｨｨ ｨｨｨｰｨｹ ｨｦ09ｨｰ09ｨｨ02ｨｬ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ ｨ ｨｺｨｰ0608ｨ AP-1 (Brooks et al., 1996) ｨｨ ﾂ02ｨｪｨｨ02 05ｨｺ ｨｨｨｨ 0002ｨｪｨ 0108ｨｮ ｨｨｨｺ05ｨｨｨｪｨ (PCNA), ｨｨ ｨｰｨｪ ｨｺｨ ｨｺ ｨｪ04ｨｦ ｨ ｨｪｨｰｨｨ0002ｨｪ ｨｨ000208ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ06ｨｺ, ｨｰ ｨｬ060005ｨ 0708ｨｨ090601ｨｨｨｰｨｹ ｨｺ 0102ｨｰ02ｨｺｨｰｨｨ08ｨｮ02ｨｬ06ｨｦ ｨｪｨ ｨｬｨｨ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｨ000208ｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ, ｨｰｨ ｨｺ ｨｺｨ ｨｺ, ｨｹ ｨｺ0600ｨ ｨｺｨｰ060806ｨｬ ｨｨｨｬ0208ｨ 0404 d, 06ｨｪ ｨｮ ﾂｨ 09ｨｰ09ｨｮ02ｨｰ ｨｨｨｺｨ 02ｨｨｨｨ ｨｰｨｪ06, ﾂｨｰ06 ｨｪｨ ｨｨｨ ｨ 0302ｨｪｨｪｨ 07 05ｨｺ ｨｨ07 05ｨｰ ｨ 0205ｨｺｨ ｨｪｨ ﾂｨｨｨｪｨ 02ｨｰ0907 ｨｪｨ 0008ｨ ｨｪｨｨ ｨ 04 G 1 /S ｨｨ 04ｨ ｨｺｨ ｨｪ ﾂｨｨ09ｨ 02ｨｰ ｨｺ06ｨｪ0202 S-00ｨ 0404 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｨｨｺ05ｨ (Matsumoto et al., 1987). 0608ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ ｨｪｨ ｨｺｨ ｨｰｨ 05ｨｨｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ 0404 (CKS2) ｨｺ ｨｨ08ｨｮ02ｨｰ ｨｪ02ｨｪｨｨ02ｨｬ ｨｮｨｪｨｺ02ｨｨｨｦ ｨｪｨｪｨｮ06 00ｨ 04ｨｮ ｨｺ0502ｨｰ06 ﾂｨｪ ｨｨｨｺ05ｨ ｨｰｨｪ06, ﾂｨｰ06 00ｨｬ0605 ﾂｨ ｨｪｨｨ ｨｰ ｨｪｨ 09 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰｨ ｨｨ090601ｨｨｨｰ ｨｺ 0609ｨｰｨ ｨｪ0609ｨｺ02 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｨｨｺ05ｨ 09 00ｨ 0402 G 2 (Martinsson-Ahlzen et al., 2008). 05ｨｪｨｨ0302ｨｪｨｨ02 ｨｮ080609ｨｪ07 05ｨｺ ｨｨｨｨ 0002ｨｪｨ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ 0404 (CDKN2C) ﾂ ｨｹ ｨｬ060302ｨｰ ｨ ｨｰｨｹ0907 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ02ｨｦ 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ0401 ｨｺｨｨｨｪｨ ｨｨ ｨｰｨｨ070609, 09ｨｪｨｨｨｬｨ ｨ ｨｪｨｨ ﾂ02ｨｪｨｨ02 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｨｨｺ05ｨ 09 00ｨ 0402 G 1 (Jeffrey et al., 2000) ｨ ｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 05ｨｺ ｨｨｨｨ 0002ｨｪ ｨｺｨ 04ｨ ｨｪ04 ｨｨ ｨ ｨｰ020507ｨｬｨｨ 0108ｨｮ0006ｨｦ 0008ｨｮ070704, ｨｰ ｨｨ0903ｨｨｨｬｨｨ, ﾂｨｰ06 ｨ ｨｺｨｰｨｨ09ｨｪｨ ｨｨ000208ｨ 02ｨｨ ｨｮ ｨｨ0701 1%-ｨｪ06ｨｦ 00ｨｨ0706ｨｺ09ｨｨｨｨ ｨ 05ｨ 09ｨｹ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02ｨｬ 05ｨｺ ｨｨｨｨ ｨｰｨ ｨｺ ｨｬｨ 08ｨｺ0208ｨ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｨ000208ｨ 02ｨｨｨｨ, ｨｺｨ ｨｺ ｨｪ04ｨｦ ｨ ｨｪｨｰｨｨ0002ｨｪ ｨｨ000208ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ06ｨｺ (PCNA). 0308ｨｨ 05ｨｰ06ｨｬ 05ｨｺ ｨｨ07 02ｨｨｨｺ05ｨｨｨｪｨ D ｨｮ090205ｨｨ ﾂｨｨ09ｨ 05ｨ 09ｨｹ ｨｬ02ｨｪｨｨ, ｨ 05ｨｺ ｨｨ07 ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ 0404 p27 09ｨｪｨｨ03ｨ 05ｨ 09ｨｹ (Hung et al., 2012). 01ｨ ｨ ｨ 02ｨｬ0602 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ02 ｨｮ080609ｨｪ07 05ｨｺ ｨｨｨｨ 0002ｨｪ ｨ ｨｪ06 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ02ｨｦ ｨｪｨｪ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｮｨｰ02ｨｦ, ｨｮ06ｨｴｨｨ01 05ｨｺ ｨｨ06 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ ｨ ｨｺｨｰ ｨｨ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609, ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｦ 02ｨｨｨｺ ｨｨ ｨ ｨｪｨｨｨｦ ｨｰ ｨｪ06, ﾂｨｰ06 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 09ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｮｨｰ02ｨｦ, ｨｮ02ｨｬ0401 ｨｬｨｨｨｰ060002ｨｪｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ04ｨｬｨｨ ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ ｨｬｨｨ (ERK, JNK ｨｨ p38), 09 ｨｮ ｨｨ ｨｨ0706ｨｺ09ｨｨｨｨ ｨ 02ｨｰ ｨｰｨｨｨｬｨｮ050702ｨｨ02ｨｦ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｨ000208ｨ 02ｨｨｨｨ (Laderoute, Webster, 1997; Scott et al., 1998; Kunz, Ibrahim, 2003). 06ｨ ｨｺ, ｨｬ0201ｨ ｨｪｨｨ04ｨｬ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｨ000208ｨ 02ｨｨｨｨ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ0609 ｨｨ 0005ｨ 01ｨｺ06ｨｬ ﾂｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 09 06ｨｰ0902ｨｰ ｨｪｨ ｨｪｨｨ04ｨｺｨｨｨｦ ｨｮ ｨｪｨｹ ｨｺｨｨ ｨ (1 %, 30 ﾂ) ｨｨｨｰ0205ｨｹｨｪ ｨｮｨｴ0209ｨｰ ｨｰ0906ｨｬ 09ｨｰ ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 ｨｺｨｨｨｪｨ 04 JNK ｨｨ p38 ｨｨ ｨ ｨｨｨｨ080609ｨ ｨｬ ｨｺ0502ｨｰ06ｨｺ ｨｨ04 00ｨ 0404 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｨｨｺ05ｨ G ｨ 04ｨｮ S (Scott et al., 1998) ｨｮ0006ｨｦ 09ｨｰ060806ｨｪ04, 09ｨｰｨｨｨｬｨｮ050702ｨｨ ｨｨ000208ｨ 02ｨｨｨｨ 0609ｨｰ0206ｨ 05ｨ 09ｨｰ ｨｨ ｨｮｨｬ020802ｨｪｨｪ06 ｨｪｨｨ04ｨｺ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ (5 %) 09 06ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ 0108ｨｮ00ｨｨ01 ｨｨ ｨ ｨｪｨｨｨｦ 06ｨｺｨ 04ｨ 05ｨ 09ｨｹ ｨｪｨ 09 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02ｨｬ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｺ05ｨ 0909ｨｨ ﾂ0209ｨｺ MAP-ｨｺｨｨｨｪｨ 04ｨｪ ｨｺｨ 09ｨｺｨ 01ｨ ﾂ ｨｺｨｨｨｪｨ 0404 ERK1/2 0708ｨｨ ｨｰ0607ｨｪｨｪ06ｨｬ ｨｮ080609ｨｪ02 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｺｨｨｨｪｨ 0404 p38 (Matsuda et al., 1998) ｨ ｨｰ0205ｨｹｨｪ06, 09 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ ｨｮ09ｨｨ0502ｨｪｨｨ07 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｪｨｨ07, ｨｨ01ｨｨｨｬ06ｨｬｨｮ, ｨｬ0600ｨｮｨｰ ｨ 04ｨｰｨｹ ﾂ02ｨｪ04 ｨｺｨ ｨｺ ERK-ｨｺｨｨｨｪｨ 0404, ｨｰｨ ｨｺ ｨｨ JNK ｨｨ ｨｨ 05ｨｰ06ｨｬ 09ｨｮｨｴ0209ｨｰ09ｨｮ02ｨｰ ｨｪｨｨ02 06 ｨｰ06ｨｬ, ﾂｨｰ06 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ04 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ 05ｨｰｨｨ01 ｨｺｨｨｨｪｨ ｨｨ 09ｨｪｨｨ0302ｨｪｨｨｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ ｨ 06ｨｰ05ｨｨ ﾂｨ 06ｨｰ ｨｰ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609, 0102ｨｦ09ｨｰ09ｨｮ06ｨｴｨｨ ｨｮ ﾂｨ 02 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｨ000208ｨ 02ｨｨｨｨ ｨｰ060904ｨｬｨｨ 00ｨ ｨｺｨｰ0608ｨ ｨｬｨｨ ｨｰｨｺｨｨ (Das et al., 2001). 00 ｨｪ02ｨｺ06ｨｰ ｨｨ ｨ ｨｪｨｨ ｨｺｨ ｨ 02ｨｰ ｨｪｨｨ02 06 ｨｰ06ｨｬ, ﾂｨｰ ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨｰ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨ ｨｪｨ 09 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ02ｨｦ 05ｨｰｨｨ01 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨｺｨ 09ｨｺｨ (Lee et al., 2011; Zonca et al., 2012). 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ ﾂ ｨｺｨ 09 ｨｮ ｨｨ ｨｪｨｨ0302ｨｪｨｪ ｨ ｨｪｨｨ07 ｨｺｨｨ ｨ ｨｨ04ｨｬ02ｨｪ0706ｨｰ ｨｨ ｨｬ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｦ09ｨｰ09ｨ, ﾂｨｰ ｨｰ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨｨｨ 08ｨ 04ｨｬ ｨｨ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｨ ｨｬ04 ｨｺ0502ｨｰ06ｨｺ, ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｨ000208ｨ 02ｨｨｨｨ, ｨｺ06ｨｰ0608ｨ 07, ｨｦ 09ｨｨ01ｨｨｨｬ0609ｨｰｨｨ, ｨｪ ｨｰ ｨｮ05ｨｹｨｰｨ ｨｰ06ｨｬ ｨｰ08ｨ ｨｪ ｨｬｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ, 0708ｨｨ ｨｴ02ｨｦ ｨｺ ｨｪ ｨ ｨｪｨｨ ﾂ02ｨｪｨｪ06ｨｬｨｮ ｨｰｨｮ ｨｺｨｮ05ｨｹｨｰｨｮ0804, 0601ｨｪｨ ｨｺ ｨ 02ｨｰ0907 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ02ｨｬ 05ｨｺ ｨｨｨｨ 0002ｨｪ0609, ｨｺ0601ｨｨ08ｨｮ06ｨｴｨｨ ｨｮ0507ｨｰ ｨｺ0502ｨｰ06 ﾂｨｪ ｨｨｨｺ05ｨ. 04ｨ ｨ 06ｨｰｨ ｨｪ02ｨｪｨ 0708ｨｨ 00ｨｨｨｪｨ ｨｪ ｨｦ ｨｺ ｨ ｨｬｨｬ ｨｨ0906ｨｺ 05ｨｨｨｰ0208ｨ ｨｰｨｮ ｨｮ08ｨ 09ｨｺ0609ｨ , 08ｨｪ0601ｨｨｨｪｨ ｨｨ07ｨｪｨｨ02 00ｨｨ0706ｨｺ09ｨｨｨｨ ｨｪｨ 09ｨｰ0806ｨｬｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ ｨｰ0902ｨｪｨｪｨｨｨｺｨｨ ｨｨ04 ｨｺ0609ｨｰｨｪ ｨｬ060400ｨ ｨｺ ｨｪｨ 08ｨ ｨｪｨｪｨｨ01 05ｨｰｨ 07ｨ 01 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ ｨｺ ｨｨｨｬ. ｨ ｨｨ0605. ｨｬ : 386 ｪ ｨｮ08ｨ 09ｨｺ0609ｨ , 0108ｨｨｨｪｨ ｨｺ060909ｨｺｨ , 08ｨｪ ｨ , 04ｨ ｨｬｨ ｨ ｨ , ｨｨ06ｨｪ0609ｨ ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺｨ ｨｬ020402ｨｪ01ｨｨｨｬｨｪ ｨｰ0806ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｨ04 05ｨｨ0706ｨ 0907ｨｨ08ｨ ｨｰｨ ﾂ ｨｺｨ, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ06ｨｬ ｨ ｨｪｨｨｨｨ ｨｺｨｨ ｨ. 00ｨｨｨｰ ｨｨ07. 51(1) : 5 ｪ ｨ , ｨ ｨ ｨｺ0609ｨ , 0206ｨｪ020609ｨ ｨｬ0208ｨ 04ｨ : 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨ, 00ｨｮｨｪｨｺ02ｨｨｨｨ ｨｨ 07ｨｮｨｰｨｨ ｨｮ050702ｨｨｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ ｨ ｨｨ ｨｨｨｬ. 50 : 155 ｪ202.