Vest_2_2006.pmd

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1 ｨｰｨｪｨｨｨｺ , ｨｨ080601ｨｪ ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04 ｨC ｨｺｨｰｨｨ09ｨｪ ｨｮ0507ｨｰ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ 00 06ｨ ｨ 09ｨｮ0301ｨ 06ｨｰ ｨｨｨｰ0208ｨ ｨｰｨｮ08ｨｪ0402 ｨｨ 0906ｨ 09ｨｰ0902ｨｪｨｪ ｨ ｨｪｨｪ ｨ ｨｨ ｨｨ ﾂ0209ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0605ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨC 08ｨ 09ｨｰｨｨｨｰ0205ｨｹｨｪ ｨｨ0002ｨｪ0605ｨｹｨｪ ｨ 0906ｨｪ06ｨｨ010609, 0708ｨｨ09ｨｮｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｴｨ 01, ｨ 01, 0008ｨｮｨｺｨｰｨ 01 ｨｨ ｨ ｨ ｨｪｨｨｨｬｨ ｨｪｨｨ07 04ｨ 0905ｨｮ03ｨｨ09ｨ 06ｨｰ ｨｨｨｰ0205ｨｹｨｪ ｨｦ09ｨｰ09ｨｨ02 ｨｪｨ ｨｨｨｬｨｬｨｮｨｪｨｪｨｮ06 ｨｨ ﾂｨｪ ｨｮ01ｨｨ09ｨｰｨｮ06 09ｨｨ09ｨｰ02ｨｬ04, ｨ ｨｪ0609ｨｰｨｹ 09ｨｪｨｨ03ｨ ｨｰｨｹ ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺ ｨｦ09ｨｰ09ｨｨ02 ｨ 05ｨｺ ｨｪｨ ｨ ｨｪｨｨ04ｨｬ. Oligomeric proanthocyanidin complexes as perspective regulators of metabolic disturbances at alcohol abuse. V.G.SPRYGIN, N.F.KUSHNEROVA (V.I.Il ｯichev Pacific Oceanological Institute, FEB RAS, Vladivostok). Data from publications and own data on biological activity of Olygomeric Proanthocyanidin Complexes, which are complex polyphenol polymers of flavonoid nature, have been discussed in the review. Olygomeric Proanthocyanidins are available in vegetables, berries, fruits and nuts in considerable amounts. OPC possess a broad spectrum of biological activity, and in particular they reduce toxic influence of alcohol on a human organism ｨ 09ｨｪｨ 09ｨｮｨｴ0209ｨｰ090609ｨ ｨｰｨ ｨｪｨｨ02, ﾂｨｰ ｨｨ 0708ｨｨ080601ｨ ｨ 05ｨ 0701, ｨｰ06 06ｨｪｨ ｨｨｨｬ0202ｨｰ ｨｺ ｨｪ02ｨｬｨｮ ｨｨ ｨｰｨｨ ｨｨ02, ｨｪｨｮ03ｨｪ06 ｨｰ0605ｨｹｨｺ ｨｪｨ ｨｦｨｰｨｨ. 07 ﾂ02ｨｪ ｨ 08ｨ ｨｰｨｨ05ｨｨ 09ｨｪｨｨｨｬｨ ｨｪｨｨ02, ﾂｨｰ ｨ ｨｦ06ｨｪｨ ｨｨｨｬｨｮｨｴ0209ｨｰ0902ｨｪｨｪ04ｨｬ 0706ｨｰ0802ｨ 0502ｨｪｨｨ02ｨｬ ｨｪｨ ｨｰｨｮ08ｨ 05ｨｹｨｪ ｨｨ08ｨｰ ｨ ｨｴｨｨ01 ｨｪｨ 07ｨｨｨｰｨｺ0609 (0808ｨ ｨｪ02ｨｨ07, 06ｨｰｨ 05ｨｨ07, ｨ ｨｪｨｨ07 ｨｨ ｨｰ.01.), ｨｰｨ ｨｺｨｨ01 ｨｺｨ ｨｺ ｨｪｨ ｨｰｨｮ08ｨ 05ｨｹｨｪ ｨｨｨｪ060008ｨ 01ｨｪ ｨｨｨｪ06, 07ｨ 0506 ﾂｨｪ04ｨｦ 09ｨｨ0108, ｨｪｨ 0601ｨｪ ﾂ ｨｺｨ ｨｪ02ｨｬ 0708ｨｨ010601ｨｨｨｰ0907 ｨ 05ｨｺ ｨ 0605ｨｹ0302, ﾂ02ｨｬ 09 08ｨ ｨｦ06ｨｪｨ ｨｨｨｬｨｮｨｴ0209ｨｰ0902ｨｪｨｪ ｨｰ0802ｨ 0502ｨｪｨｨ ｨｺｨｨ ｨｨ 0108ｨｮ00ｨｨ01 ｨｺ080207ｨｺｨｨ01 ｨｪｨ 07ｨｨｨｰｨｺ0609, ｨ ｨｴｨｨ01 ｨｰ0605ｨｹｨｺ06 01ｨｨ09ｨｰｨｨ0505ｨｨ080609ｨ ｨｪｨｪ04ｨｦ ｨ 05ｨｺ ｨｹ. 0201ｨｪｨ ｨｺ ｨｨｨｪｨｪ ｨｪｨ ｨｬ02ｨｪ ｨｪ04 ｨ 05ｨｺ ｨｨ04ｨｬｨｮ, ﾂ02ｨｬ ﾂｨｪ [1]. 02ｨ ｨｪｨｪ04ｨｦ 0002ｨｪ06ｨｬ02ｨｪ, ｨｨ01ｨｨｨｬ06ｨｬｨｮ, 06ｨ ｨｮ ｨｪ ｨｺ06ｨｬ070502ｨｺ0906ｨｬ 0902ｨｴ0209ｨｰ09, ｨ ｨｴｨｨ ｨｨｨｪ060008ｨ 0102 ｨｨ 07ｨ 0506ｨｺｨ 01 ｨｨ ｨ ｨｪ ｨｨ07ｨｰｨｹ ｨｪｨ ｨ ｨｬ02ｨｪｨ 05ｨｰｨ ｨｪ0605ｨ ｨ ｨｪｨｨ04ｨｬ02, 09ｨｬ0700 ﾂｨ ｨｪ ｨｦ09ｨｰ09ｨｨ02 ｨｪｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬ ｨｨ ｨｮ09ｨｺ ｨｨｨｬｨｨｨｪｨ 02ｨｨ06 ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺｨｨ ｨｮｨｺｨｰ0609 ｨｨ ｨ ｨｪｨｨ04ｨｬｨ. 0206ｨｬｨｨｨｪｨｨ08ｨｮ06ｨｴｨｨｨｬ ｨｺ05ｨ ｨｬ ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ ｨｨｨｪ02ｨｪｨｨｨｦ 09ｨｨｨｪ060008ｨ 01ｨ ｨｨ 07ｨ 0506ｨｺ, ｨ ｨ ｨｰ0205ｨｹｨｪ06, ｨｨ ｨ 05ｨｺ ｨｹｨｪ0401 ｨｪｨ 07ｨｨｨｰｨｺ0609, ｨｮ ﾂｨ 02ｨｬ0401 ｨｪｨ 0609ｨｪ ｨｨ ｨ ｨ 06ｨｰｨｺｨｨ, ｨｰ0907 ｨｰｨ ｨｺ ｨｪｨ ｨ 02ｨｬ0402 ｨｺ06ｨｬ070502ｨｺ ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609, ｨｨ05ｨｨ ｨｺ06ｨｪ0102ｨｪ09ｨｨ080609ｨ ｨｪｨｪ0402 ｨｰｨ ｨｪｨｪｨｨｨｪ04, ｨｰｨ ｨｴｨｨ ｨ 06ｨｦ ｨｨｨｬ0208ｨｪ ｨｬ ｨ 0906ｨｪ06ｨｨ ｨｨ ｨｮ ｨｺｨ ｨｰ0201ｨｨｨｪ ｨ ｨｪｨｨ02 09 ｨｮｨｺｨ 04ｨ ｨｪｨｪ0401 ｨｪｨ 07ｨｨｨｰｨｺｨ 01 ｨｬ060302ｨｰ ｨｰｨｨ00ｨ ｨｰｨｹ 700 ｨｬ00/05 ｨｨ ｨ [37]. 0905ｨ ｨ ｨ 02ｨｪｨｪ0609ｨｰ07ｨｬ 01ｨｨｨｬｨｨ ﾂ0209ｨｺ ｨｰ080602ｨｪｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨ ｨｪ ｨｰｨｮ07ｨ ｨｰｨｹ 09 ｨｺｨ ﾂ0209ｨｰ ｨ ｨｬ0609ｨｰ0607ｨｰ0205ｨｹｨｪ06ｨｦ 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 (01ｨｨｨｪ06ｨｪｨC0902ｨｬｨｨ01ｨｨｨｪ06ｨｪｨC0002ｨｪ0605), 06ｨｺｨ ｨ 07 ｨｪ ｨｰ0902ｨｪｨｪ ｨｨ07ｨｪｨｨ02 ｨｪｨ ｨｪ ｨｰ06ｨｪ0609 ｨｨ ｨｺｨｰ0806ｨｪ0609 [11] ｨ 01 06ｨ ｨｬ02ｨｪｨ 05ｨｰｨ ｨｪ0605ｨ ｨｨ ｨｪｨ ｨｨｨ ｨｰ06ｨｺ09ｨｨ ﾂｨｪ ｨｬ02ｨｰｨ ｨ 0605ｨｨｨｰｨ ｨC ｨｮｨｺ09ｨｮ09ｨｪ ｨ 05ｨｹ010200ｨｨ01ｨ ｨ 01ｨｨｨｬｨｨ ｨｪｨｪｨ 01ｨｹ0209ｨｨ ﾂ ｨC ｨｺｨ ｨｪ01ｨｨ01ｨ ｨｰ ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪｨ ｨｮｨｺ, ｨ ｨｰｨ 05ｨｹ ｨｪｨ ｨC 0106ｨｺｨｰ0608 ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪｨ ｨｮｨｺ (06ｨｨ010606ｨｺ02ｨ ｨｪ09ｨｺｨｨｨｦ 06ｨｺ02ｨ ｨｪ ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｨｨｬ ｨｹｨｨ ﾂ0209ｨ , 0005ｨ 01ｨｨ090609ｨｰ06ｨｺ). 81

2 130205ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04 ｨC 0601ｨｪｨｨ ｨｨ04 09ｨ ｨｬ0401 ｨｨｨｪｨｰ ｨｪ0401 ｨｨ 09ｨ 03ｨｪ ﾂ ｨｺｨ ｨｰｨ 09ｨｨｨｰ020502ｨｦ 08ｨ 09ｨｰｨｨｨｰ0205ｨｹｨｪ ｨｨ0002ｨｪ0605ｨｹｨｪ ｨｨｨｪ02ｨｪｨｨｨｦ ｨ ｨｨ09ｨｰ08ｨｨ080609ｨ ｨｪｨｪ ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 09 ｨｺｨ ﾂ0209ｨｰ0902 ｨｰ0208ｨ ｨｰｨｨ ﾂ0209ｨｺ ｨｰ09ｨ 06ｨｰｨｪ0609ｨｨｨｰ0907 ｨｺ , ｨｺ060001ｨ ｨｨｨｪ0102ｨｦ ｨｺｨ 04ｨ 05ｨｨ ｨ ｨｬ0208ｨｨｨｺｨ ｨｪ09ｨｺｨｨｨｬ 07ｨｮｨｰ ｨｰ0902ｨｪｨｪｨｨｨｺｨ ｨｬ, ｨｺｨ ｨｺ 04ｨ 09ｨ 08ｨｨ09ｨ ｨｰｨｹ ｨｺ0608ｨｮ ｨｪ04, ﾂｨｰ06ｨ ｨｮ ﾂｨｨｨｰｨｹ ﾂｨ ｨｦ, ｨｰ0908ｨ ｨｴｨ 06ｨｴｨｨｨｦ 08ｨ 0409ｨｨｨｰｨｨ02 02ｨｨｨｪ00ｨｨ [19]. 0105ｨ 09ｨｪ ｨｰ05ｨｨ ﾂｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｰ 0609ｨｰｨ 05ｨｹｨｪ ｨｨ0002ｨｪ0605ｨｹｨｪ ｨｨｨｪ02ｨｪｨｨｨｦ 09 ｨｰ06ｨｬ, ﾂｨｰ06 06ｨｪｨｨ ｨｰｨ ｨｰ 0609ｨｪ0609ｨｪｨｮ06 ( %) ﾂｨ 09ｨｰｨｹ 0706ｨｰ0802ｨ ｨｬ0401 ﾂ ｨｺ06ｨｬ ｨ ｨｨ060005ｨ 0906ｨｪ06ｨｨ ｨｬｨｨ ｨ 0600ｨ ｨｰ04 08ｨ 09ｨｰ02ｨｪｨｨ07, 0008ｨｮｨｺｨｰ04 ｨｨ ｨｪｨ ｨｰｨｮ08ｨ 05ｨｹｨｪ0402 ｨｪｨ 07ｨｨｨｰｨｺｨｨ, ｨｺ06ｨｰ ｨｨ ｨｹ040609ｨ 05ｨｨ09ｨｹ ﾂ ｨｺ06ｨｬ 09 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0401 ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ ｨｪ0204ｨ 07ｨ ｨｬ07ｨｰｨｪ ｨｬ02ｨｪ ｨｰ0802ｨ 0502ｨｪｨｨ02 09ｨｨｨｪｨ, ｨｪｨ 0708ｨｨｨｬ0208, ｨｪｨ 09 ﾂｨｨｨｰ0409ｨ 02ｨｰ ｨｮ0302 ｨ ｨｰ ｨｬ02 09ｨｨｨｪｨ ｨｨ0906ｨｺ ｨｮｨｺｨｰ ｨｨｨｰｨ ｨｪｨｨ07, ｨ 0600ｨ ｨｰ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ ｨｬｨｨ ｨｨ ｨｬ06ｨｪ06ｨｬ0208ｨｪ04ｨｬｨｨ ｨｺｨ ｨｰ0201ｨｨｨｪｨ ｨｬｨｨ, ｨｰ 09ｨｨｨｪ060008ｨ 01, 07ｨ 0506ｨｺｨｨ, ｨ 06ｨ 04, ｨｪｨｨ02ｨ, ｨ ｨｰｨ ｨｺ0302 ｨｺｨ ｨｺｨ 06, ｨｺ060002, 07ｨ 0506 ﾂｨｪ04ｨｦ 09ｨｨ0108, ﾂｨ ｨｦ ｨｨ [37] ｨ 09ｨｪ06 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬ 01ｨ ｨｪｨｪ04ｨｬ, ｨｪ0209ｨｪ ｨｰ0802ｨ 0502ｨｪｨｨ02 ｨ ｨｨ060005ｨ 0906ｨｪ06ｨｨ ｨ 09ｨｰｨｨｨｰ0205ｨｹｨｪ06ｨｦ 07ｨｨｨｴ02ｨｦ ｨｦ09ｨｺｨｨ01 09ｨｰ08ｨ ｨｪｨ ｨｰｨｨ00ｨ 02ｨｰ 1,5 00 [24]. 0209ｨｪ0609ｨｪｨｮ06 ﾂｨ 09ｨｰｨｹ 06ｨｰ 05ｨｰ ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ ｨｰｨ ｨｰ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04 ｨｨ ｨｨ01 ｨｬ06ｨｪ06ｨｬ0208ｨｪ ｨｪｨｹ07 ｨC ｨｺｨ ｨｰ0201ｨｨｨｪ04 ｨｨ 0502ｨｦｨｺ06ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04, ｨｰｨ ｨｺ ｨｺｨ ｨｺ ｨｰ0605ｨｹｨｺ06 05ｨｰｨｨ ｨｨｨｪ02ｨｪｨｨ ｨ 0906ｨｪ06ｨｨ01ｨｪ06ｨｦ 0708ｨｨ ｨ ｨｪ04 06ｨ 08ｨ ｨ ｨｰｨｹ ｨｨｨｬ0208ｨｪ ｨｰ08ｨｮｨｺｨｰｨｮ ｨ 03ｨｪ0609ｨｰｨｹ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｺｨ ｨｺ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰｨ ｨｨｨｰｨ ｨｪｨｨ07 06ｨ ｨｮ ｨｨ05ｨ ｨｪｨｨ02 06 ﾂｨｨｨｴ02ｨｪｨｪ0401 ｨｺ06ｨｬ070502ｨｺ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｺｨ ﾂ0209ｨｰ0902 ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ ｨ ｨ 0906ｨｺ ｨｺ 07ｨｨｨｴ ｨｪ02ｨｺ06ｨｰ ｨｰ08ｨ ｨｪｨ ｨ ｨｪ04 ｨ 01ｨｬｨｨｨｪｨｨ09ｨｰ08ｨ ｨｰｨｨ09ｨｪ ｨ ｨｪ04, ｨｮ05ｨｨ08ｨｮ06ｨｴｨｨ02 ｨｨ01 ｨｺｨ ﾂ0209ｨｰ0906 ｨｨ ｨｮ0706ｨｰ0802ｨ 0502ｨｪｨｨ02. 06ｨ ｨｺ, ｨ 05ｨｹｨｪ04ｨｦ ｨｺ06ｨｬｨｨｨｰ02ｨｰ ｨｮ05ｨｨ08ｨｮ02ｨｰ ｨｺｨ ﾂ0209ｨｰ ｨｰｨｮ07ｨ 06ｨｴ ｨｪｨ 0804ｨｪ06ｨｺ 05ｨｺ09ｨｰ08ｨ ｨｺｨｰｨ ｨｨ04 09ｨｨｨｪ060008ｨ 01ｨｪ0401 ｨｺ0609ｨｰ06 ﾂ02ｨｺ. 06ｨｺ09ｨｰ08ｨ ｨｺｨｰ ｨｰｨ ｨｰ 0906ｨ 06ｨｦ ｨｺ06ｨｬ070502ｨｺ ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609, ｨｪｨ ｨｨｨ ｨｨ0806ｨｺ ｨｨｨｬ02ｨｪ0702ｨｬ04ｨｦ 09 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨｰ06 ﾂｨｺｨｨ ｨｪｨｨ07 01ｨｨｨｬｨｨ ﾂ0209ｨｺ ｨｰ080602ｨｪｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｰｨ ｨｰ 0906ｨ 06ｨｦ ｨｨｨｬ0208ｨｪ ｨ 09ｨ ｨｪ , ｨｺ06ｨｰ ｨｨｨｬ0206ｨｰ ｨｰｨｨ07ｨｨ ﾂｨｪ04ｨｦ ｨ 0906ｨｪ06ｨｨ01ｨｪ04ｨｦ 09ｨｺ020502ｨｰ. 01ｨ ｨｨｨ ｨｨ0806ｨｺ ｨｨｨｴ ｨｮｨｺｨｰｨ 01 08ｨ 09ｨｰｨｨｨｰ0205ｨｹｨｪ ｨｨ ｨｪｨｨ07 08ｨ ｨｰ08ｨ ｨｪ02ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨ ｨｪｨｨ02ｨｬ 00ｨｨ010806ｨｺ09ｨｨ05ｨｹｨｪ ｨｮ ｨｪｨｨｨｨ 3',4'- 09 ｨｺ0605ｨｹ ｨｨ ｨｹ00ｨｨｨｪｨｨ01ｨｨｨｪ ',4',5'-ｨｰ08ｨｨ00ｨｨ010806ｨｺ09ｨｨ-04ｨ ｨｬ02ｨｴ02ｨｪｨｨ02ｨｬ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04 ﾂｨ 09ｨｰ ｨｰ0802 ﾂｨ 06ｨｰ ｨ 09ｨｰｨｨｨｰ0205ｨｹｨｪ ｨｮｨｺｨｰｨ 01 ｨｨ ｨｪｨ 07ｨｨｨｰｨｺｨ ｨｬ0209ｨｨ ｨｹ00ｨｨｨｪｨｨ01ｨｨｨｪｨ ｨｬｨｨ [37] ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04 09ｨｮｨｴ0209ｨｰ09ｨｮ06ｨｰ 09 09ｨｨ ｨ 09ｨｰ090608ｨｨｨｬ ｨｨ0006ｨｬ , ｨ ｨｴｨｨ01 06ｨｰ 0109ｨｮ ｨｰｨｨ 00ｨｺｨ ｨｰ0201ｨｨｨｪ ｨｨｨｪｨｨ02, ｨ ｨｰｨ ｨｺ ｨｨ0102 ｨｪ0208ｨ 09ｨｰ090608ｨｨｨｬ ｨｨｨｬ ｨｰ020702ｨｪｨｹ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ 06ｨｰ 7 ｨｨ , ｨｺ06ｨｰ ｨｰｨ ｨｰ 0906ｨ 06ｨｦ 0609ｨｪ0609ｨｪｨｮ06 ( %) ﾂｨ 09ｨｰｨｹ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｺ06ｨｬ070502ｨｺ [23]. 08ｨ ｨｰ0201ｨｨｨｪ ｨｨｨｪｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ ｨｪ0609ｨｪ06ｨｬ ｨ ｨｪ04 ﾂ ｨ ｨｰ06ｨｬ04 ｨｮ ｨ, ｨｪｨ ｨｴｨｨ ｨｬ, 8-ｨｬ ｨｨ05ｨｨ 6-ｨｬ ｨｪｨｨ0701 (08ｨｨ09. 1). 06ｨ ｨｺｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04 06ｨｰｨｪ060907ｨｰ0907 ｨｺ ｨｰｨｨ07ｨｮ 00 (01ｨｨｨｬ020804) ｨｨ ｨｰｨｨ07ｨｮ 05 (ｨｰ08ｨｨｨｬ020804) (08ｨｨ09. 2) ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｰｨｨ07ｨ ｨｬ06ｨｪ06ｨｬ0208ｨｪ ｨｨｨｪｨｨ ｨ ｨｪ ｨｮｨｬ ｨｬｨｨ (0601ｨｪ06ｨｦ 05ｨC05 ｨｨ 0601ｨｪ06ｨｦ 05ｨC02) (08ｨｨ09. 2). 08ｨｨ04ｨｨｨｺ06-01ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ ｨｦ09ｨｰ09ｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609, 06ｨ ｨｮ ｨｨ09ｨ 06ｨｴｨｨ02 ｨｨ01 ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｺ0605ｨｹｨｺｨｮ ｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｰ0802 ﾂｨ 06ｨｰ ｨｨ ｨｬ0209ｨｨ 0605ｨｨ0006ｨｬ ｨ 0405ｨｨ ﾂｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ, ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ ｨ ｨ 06ｨｰ 0706 ｨｨ04ｨｮ ﾂ02ｨｪｨｨ06 ｨｨ01 ｨ ｨｨ ｨｨ ﾂ0209ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ in vivo ｨｨ in vitro ｨｨ050609ｨｹ ｨ 08ｨ ｨｰｨ ｨｬｨｨ, ｨ ｨｴｨｨｨｬｨｨ ｨｬ06ｨｪ06ｨｬ0208ｨｪ0402 ｨｺｨ ｨｰ0201ｨｨｨｪ04, 0605ｨｨ0006ｨｬ0208ｨｪ0402 ｨｨ ｨｨｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04. 02ｨ ｨｪｨ 08ｨｮ03ｨｨ09ｨ 02ｨｬ0402 ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨｺｨｰ04 ｨ 0405ｨｨ 06ｨ ｨｮ ｨｪ ｨ ｨｪ0609ｨｰｨｹ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨ ｨｰｨｹ ｨ 0205ｨｺｨｨ, ｨ ｨｰｨ ｨｺ0302 ｨｨ01 ｨ ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰｨｪ06ｨｦ, ｨ ｨｪｨｰｨｨ08ｨ 01ｨｨｨｺｨ 05ｨｹｨｪ06ｨｦ, ｨ ｨｪｨｰｨｨｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 [37]. 02ｨｰ ﾂｨｨ0905ｨ 0002ｨｪ0605ｨｹｨｪ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｮ ｨｬ060502ｨｺｨｮ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ 04ｨ 09ｨｨ0907ｨｰ ｨｰ08ｨｨ 0609ｨｪ0609ｨｪ ｨｦ09ｨｰ09ｨ : 06ｨ 08ｨ ｨ ｨｪｨｨ02 ｨｰｨ ｨｪｨｪｨｨｨｪ-ｨ 0205ｨｺ ｨｺ06ｨｬ070502ｨｺ090609, ｨ ｨｰｨｪ ｨｨｨｪ02ｨｪｨｨｨｦ 09 ｨｬ02ｨｰｨ 0505ｨ ｨｬｨｨ ｨｨ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ04ｨｦ 0706ｨｰ02ｨｪ02ｨｨｨ

3 1304ｨｨ ｨ ｨ 07 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609: R 1, R 2 =H ( ｨ ｨｪｨｨ01ｨｨｨｪ04); R 1 =H, R 2 =OH ( ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04); R 1, R 2 =OH ( ｨｹ00ｨｨｨｪｨｨ01ｨｨｨｪ04) [37] 0004ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ02 09 ｨ 0205ｨｺｨ ｨｬｨｨ. 0201ｨｪｨｨｨｬ ｨｨ04 ｨｪｨ ｨｨｨ ｨｨ ｨｰｨｪ ｨｦ09ｨｰ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｺｨ ｨｺ ｨｨｨｪ02ｨｪｨｨｨｦ, 06ｨｰｨｪ060907ｨｴｨｨ ｨｺ ｨｺ05ｨ 0909ｨｮ ｨｰｨ ｨｪｨｪｨｨｨｪ0609, ｨｰ0907 ｨｨ ｨ ｨｪ0609ｨｰｨｹ ｨ ｨｰｨｹ ｨ 0205ｨｺｨ ｨｬｨｨ ｨｺ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ07 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ06ｨｰ0907 ｨｺｨ ｨｺ 06ｨ 08ｨ ｨｰｨｨｨｬ ｨｨｨｪｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ ｨｪ0609ｨｰｨｪ ｨｪｨｨ07, 06ｨ ｨｮ ｨｪｨｪ ｨｨ ｨ ｨｪ04ｨｬ 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ02ｨｬ ｨｨ 06ｨ 08ｨ ｨ ｨｪｨｨ02ｨｬ ｨｪ ｨｦ ｨｬ020301ｨｮ 0002ｨｪ0605ｨｹｨｪ04ｨｬｨｨ 0008ｨｮ0707ｨ ｨｬｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｨ ｨｺｨ 08ｨ 06ｨｪｨｨ05ｨｹｨｪ04ｨｬｨｨ 0008ｨｮ0707ｨ ｨｬｨｨ ｨ 0205ｨｺ0609 [23] ﾂｨｪ0609ｨｰｨｹ 06ｨ 08ｨ 04ｨｮ06ｨｴｨｨ ｨｦ 04ｨ 09ｨｨ09ｨｨｨｰ ｨｺｨ ｨｺ 06ｨｰ 0708ｨｨ ｨ 0205ｨｺｨ, ｨｰｨ ｨｺ ｨｨ 06ｨｰ 0708ｨｨ ｨｬ060502ｨｺｨｮ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ, ｨ 02ｨｪｨｪ0609ｨｰｨｨ 06ｨｰ 0202 ｨｬ060502ｨｺｨｮ050708ｨｪ ｨ, 09ｨｰ020702ｨｪｨｨ 00ｨ ｨｨ04ｨ 02ｨｨｨｨ ｨｨ 00ｨｨ010806ｨｺ09ｨｨ05ｨｨ080609ｨ ｨｪｨｨ ｨ 09ｨｰｨ ｨｪｨｨ02ｨｬ ﾂｨｨ090502ｨｪｨｪ ｨ 08ｨ ｨｬ02ｨｰ ｨｮ090205ｨｨ ﾂｨｨ09ｨ 02ｨｰ ｨｰ020702ｨｪｨｹ ｨｰ09ｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｺ ｨ 0205ｨｺｨ ｨｬ ｨｨ, ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06, ﾂｨｪ0609ｨｰｨｹ ｨ ｨｺ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ07 [22] ｨｺｨｨ 09 ｨｺ06ｨｬ07ｨ ｨｺｨｰｨｪ06ｨｦ ｨ ｨｮ050708ｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ0806ｨｦ ｨｨｨｬ0206ｨｰ ｨ ｨｪｨｨ04ｨｺ ｨｰ0906 ｨｺ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ ｨｬ, ﾂ02ｨｬ ｨ 0205ｨｺｨｨ 09 ｨ ﾂｨｪ06ｨｦ 0907ｨｨ08ｨ 05ｨｹｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ0806ｨｦ. 00 ｨｮ ｨｨ0701, ｨｺ060001ｨ ｨｺ06ｨｬ07ｨ ｨｺｨｰｨｪ ｨ ｨｮ050708ｨｪ0402 ｨ 0205ｨｺｨｨ ｨｰ ｨｰ ｨｰ0608ｨｨ ﾂｨｪｨｮ06 ｨｨ ｨｰ0802ｨｰｨｨ ﾂｨｪｨｮ06 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｮ, ｨ 09ｨｰｨ 02ｨｰ ｨｨ ｨｨ ｨｰ0906 ｨｺ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ ｨｬ [22]. 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｬｨ ｨｺ0806ｨｬ060502ｨｺｨｮ05ｨ ｨｬｨｨ 09 ｨ ｨｨ ｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ02 ｨｬ060302ｨｰ 0708ｨｨ090601ｨｨｨｰｨｹ ｨｺ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｨ04ｨｨｨｺ06-01ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ01 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺ, 06ｨｺｨ ｨ ｨｨ07ｨｪｨｨ02 ｨｪｨ 09ｨｨ09ｨｰ02ｨｬｨｮ ｨｬ. 06ｨｬ02ｨｪｨｪ ｨ ｨｪ0609ｨｰｨｹ 06ｨ 08ｨ ｨ ｨｰｨｹ ｨｰｨ ｨｪｨｪｨｨｨｪ-ｨ 0205ｨｺ ｨｨ, ｨｪｨ ｨｮ 09 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ04ｨｬｨｨ ｨｦ09ｨｰ09ｨ ｨｬｨｨ, 06ｨ ｨｮ ｨｨ09ｨ 02ｨｰ ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ06ｨｴ ｨｦ09ｨｰ09ｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｪｨ ｨｺ09ｨ ｨｪｨｰｨｨｨｪ06ｨｺ09ｨｨ01ｨ 04ｨｮ, ｨｺ060505ｨ 0002ｨｪｨ 04ｨｮ, ｨ 02ｨｰｨ ｨｺｨｮ0806ｨｪｨｨ01ｨ 04ｨｮ ｨｨ 00ｨｨｨ 05ｨｮ0806ｨｪｨｨ01ｨ 04ｨｮ [27], ｨｺ06ｨｰ ﾂｨｨｨｰｨ 06ｨｰ0907 ｨｺ0506 ﾂ020904ｨｬｨｨ ｨｬ02ｨｪｨｰｨ ｨｬｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ01 ｨｺｨ 09ｨｺｨ ｨｺｨ 07ｨｨ ｨｪ ｨｪ0106ｨｰ0205ｨｨ07 [26] ｨｨ 09ｨｪ ｨｮ01ｨｨ09ｨｰ ｨｬｨ ｨｰ08ｨｨｨｺ09ｨ ｨｪ0202 ｨｬ02ｨｰ0601ｨ ｨｬｨｨ ｨｹ070806ｨｪｨｨｨｺｨ 06ｨｴ02ｨｦ ｨｬｨ ｨｰ060008ｨ 00ｨｨｨｨ ｨｨ ｨｺｨｰ ｨ ｨ ｨｮ09ｨｰｨ ｨｪ ｨｪ06 ｨｪ ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨ ｨｪｨｨ02 ｨｰｨ ｨｪｨｪｨｨｨｪ-ｨ 0205ｨｺ ｨｺ06ｨｬ070502ｨｺ09ｨ 09 ｨｺ09ｨ ｨｪｨｰｨｨｨｪ06ｨｺ09ｨｨ01ｨ 0406ｨｦ [28]. 01ｨｨ ｨ ｨｪ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ ｨ ｨｪｨｪ06ｨｬ 0905ｨｮ ﾂｨ 02 ｨｨ0008ｨ ｨ 09ｨｪｨｮ ｨｹ 09 ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ06ｨｴ02ｨｬ 0102ｨｦ09ｨｰ09ｨｨｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｪｨ ｨｨ ﾂｨｪ04ｨｦ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ ｨｨｨｬ0205 ｨｬ0209ｨｰ06 ｨｨ ｨｮ ﾂｨ 02 ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ ｨｬｨｨ ｨｺｨ ｨｰｨ 05ｨ 0404, ｨｪ ｨｨ 05ｨｰ06ｨｬ ｨｪ02 04ｨ ｨｰ08ｨ 00ｨｨ09ｨ 05ｨ 09ｨｹ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 09ｨｮ ｨｺ09ｨｨ0101ｨｨ09ｨｬｨｮｨｰｨ 0404 [28]. 02ｨ 08ｨ ｨ ｨｪｨｨ02 ｨｺ06ｨｬ070502ｨｺ ｨｬ02ｨｰｨ 0505ｨ ｨｬｨｨ. 08ｨ ｨｺ ｨｨ 0108ｨｮ00ｨｨ ｨｨ0002ｨｪ0605ｨｹｨｪ ｨｨｨｪ02ｨｪｨｨ07, 06ｨ 05ｨ 01ｨ 06ｨｴｨｨ ｨｪ0605ｨｹｨｪ04ｨｬｨｨ 0008ｨｮ0707ｨ ｨｬｨｨ, ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｰ ｨｰ05ｨｨ ﾂｨｪ04ｨｬｨｨ ｨ ｨｰ0608ｨ ｨｬｨｨ ｨｰ ｨ 0502ｨｪｨｰｨｪ ｨ. 0308ｨｨ ｨｪ02ｨｦｨｰ08ｨ 05ｨｹｨｪ ｨｪｨ ﾂ02ｨｪｨｨ ｨｨ ｨｨ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ ｨｪｨ ｨｨｨｰ ｨｨ0102 ｨｺ06ｨｬ070502ｨｺ09ｨ 09 ｨｺｨ ｨｰ ｨ ｨｰｨｪ04ｨｬｨｨ 0008ｨｮ0707ｨ ｨｬｨｨ 0109ｨｮ01 05ｨｨ00ｨ ｨｪ [39] ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04 ｨｰｨ ｨｺ ｨ ｨｪ04 06ｨ 08ｨ ｨ ｨｰｨｹ ｨｺ06ｨｬ070502ｨｺ ｨｰ ｨ 0502ｨｪｨｰｨｪ04ｨｬ 83

4 1304ｨｨ ｨｰ08ｨｮｨｺｨｰｨｮ0804 ｨｪ02ｨｺ06ｨｰ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨC 01ｨｨｨｬ ｨｨ ｨｰ08ｨｨｨｬ , 00 ｨｨ 05 ｨｰｨｨ [37]. 1 ｨC 001: R 1 =OH; R 2 =H; R 3 =H; R 4 =OH; 002: R 1 =OH; R 2 =H; R 3 =OH; R 4 =H; 003: R 1 =OH; R 3 =H; R 4 =OH; 004: R 1 =OH; R 3 =OH; R 4 =H; 2 ｨC B5: R 1 =OH; R 2 =H; R 3 =H; R 4 =OH; B6: R 1 =OH; R 3 =OH; R 4 =H; B7: R 1 =OH; R 3 =H; R 4 =OH; B8: R 1 =OH; R 3 =H; R 4 =OH; 3 ｨC C1: R 1 =OH; R 2 =H; C2: R 1 =OH; 4 ｨC A2 ｨ 0506ｨｬｨｨｨｪｨｨ02ｨｬ ｨｨ 0109ｨｮ0109ｨ 0502ｨｪｨｰｨｪ06ｨｦ ｨｬ0201ｨｹ06 [34]. 0806ｨｬ070502ｨｺ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｬ02ｨｰｨ 0505ｨ ｨｬｨｨ ｨｺ ｨ 01ｨ 06ｨｰ ｨ 0106ｨｺ 0708ｨｨ ｨｪ02ｨｦｨｰ08ｨ 05ｨｹｨｪ ｨｰ06ｨｬ 0905ｨｮ ﾂｨ 02, ｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07 05ｨｨ00ｨ ｨｪ01ｨ (070806ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ ) ｨｪ ｨｨ03ｨｺ06ｨｬ ｨ 02ｨｰ ｨｰｨ ｨｺ0609ｨｮ ｨｨ06ｨｪｨ ｨｬ02ｨｰｨ 0505ｨ. 01ｨ ｨｨｨ ｨ 03ｨｪ04ｨｬ ｨｬ02ｨｰｨ ｨｬ ｨｬ02ｨｪｨｪ06ｨｦ 09ｨ 0502ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｨ04ｨｪ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｰ , ｨｺ06ｨｰ ｨｪ02 ｨｰ0605ｨｹｨｺ06 ｨｮ ﾂｨ 09ｨｰ09ｨｮ02ｨｰ 09 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ ｨ 01, ｨｪ06 ｨｨｨｬ0202ｨｰ ｨｦ ｨｮ00ｨｨ01 00ｨｮｨｪｨｺ02ｨｨｨｦ, ｨｰｨ ｨｺｨｨ01 ｨｺｨ ｨｺ 0108ｨ ｨｪ02ｨｪｨｨ02 ｨｨ ｨｰ08ｨ ｨｪ ｨｰｨｨ080609ｨｺｨ ｨｺｨｨ ｨ, ｨｪ ｨｺｨｰ0806ｨｪ0609, 0802ｨ ｨｺ02ｨｨｨｨ 00ｨｨ010806ｨｺ09ｨｨ05ｨｨ080609ｨ ｨｪｨｨ07, ｨｮｨｰｨｨ05ｨｨ04ｨ 02ｨｨ ｨｺｨｨ09ｨｨ ｨ, 01ｨｨ09ｨｬｨｮｨｰｨ 02ｨｨ07 09ｨｮ ｨｺ09ｨｨ01-ｨ ｨｪｨｨ06ｨｪｨ ｨｰ06ｨｬｨｮ ｨ ｨｪ0609ｨｰｨｹ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨ ｨｰｨｹ ｨｨ06ｨｪ ｨ 06ｨ ｨｮ ｨｨ09ｨ 02ｨｰ ｨ ｨｪｨｨ ﾂ02ｨｪｨｨ02 ｨ ｨｨ ｨｰｨｮ07ｨｪ0609ｨｰｨｨ ｨｪ020002ｨｬ ｨ ｨｨ ｨｮ0106 ﾂｨｪ06-ｨｺｨｨ0302 ﾂｨｪ ｨｰ08ｨ ｨｺｨｰｨ ｨｬ ｨｰ ｨ 01ｨｨｨｺｨ 05ｨｹｨｪ06ｨｦ ﾂｨ 09ｨｰｨｨ0202ｨｦ, ｨｰ06ｨｬｨｮ 09ｨｪｨｨ0302ｨｪｨｨ ｨｮ080609ｨｪ ｨ ｨ ｨｰ ｨｪｨ 0008ｨｮ04ｨｺｨｮ ｨｪｨ ｨ ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰｨｪｨｮ06 04ｨ ｨｴｨｨｨｰｨｪｨｮ06 09ｨｨ09ｨｰ02ｨｬｨｮ ｨ ｨｪｨｨ02 ｨｨ06ｨｪ0609 ｨ 0506ｨｬｨｨｨｪｨｨ07 ｨC ｨｰｨ ｨｺ ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ ｨｪｨｨ02 ｨ ｨｨ ｨｨ ﾂ0209ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨ 04ｨｰ06ｨｺ ｨ 0506ｨｬｨｨｨｪｨｨ ｨ 02ｨｰ 08ｨｨ09ｨｺ 04ｨ ｨ ｨ ｨｪｨｨ07 ｨ ｨｪｨｹ ｨｹ020002ｨｦｨｬ0208ｨ, ｨ ｨｮｨｬ020802ｨｪｨｪ0602 ｨｮ0706ｨｰ0802ｨ 0502ｨｪｨｨ02 ｨｺ08ｨ 09ｨｪ ｨｨｨｪｨ ｨ ｨｪ06 09ｨｪｨｨ04ｨｨｨｰｨｹ 08ｨｨ09ｨｺ 08ｨ 0409ｨｨｨｰｨｨ07 09ｨｰｨ 08 ﾂ0209ｨｺ ｨ ｨ 06ｨｮｨｬｨｨ07 [29]. 84

5 ｨｬ 06ｨ 08ｨ ｨ ｨｪｨｨ02 ｨｺ06ｨｬ070502ｨｺ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｬ02ｨｰｨ 0505ｨ ｨｬｨｨ, ｨｺｨ ｨｺ ｨｨ ｨｰ02ｨｨｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｺ06ｨｬ070502ｨｺ090609, ｨ ｨｪｨｨ ﾂ02ｨｪ ｨｮ0106 ﾂｨｪ06-ｨｺｨｨ0302 ﾂｨｪ04ｨｬ ｨｰ08ｨ ｨｺｨｰ06ｨｬ. 08ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰｨｪ0402 ｨｨ ｨ ｨｪｨｰｨｨ08ｨ 01ｨｨｨｺｨ 05ｨｹｨｪ ｨｦ09ｨｰ09ｨ. 04ｨ ｨ 06ｨｰ, ｨｴ02ｨｪｨｪ0401 ｨｨ04ｨｮ ﾂ02ｨｪｨｨ06 ｨ ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰｨｪ06ｨｦ ｨｨ ｨ ｨｪｨｰｨｨ08ｨ 01ｨｨｨｺｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609, 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 ｨｬ02ｨｪｨｹ0302, ﾂ02ｨｬ ｨｬ06ｨｪ06ｨｬ0208ｨｪ ｨ 0906ｨｪ06ｨｨ ｨｨ ｨｺｨ ｨｰ0201ｨｨｨｪ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨ ｨｪ ｨｺｨｰｨｨ09ｨｪ06 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｰｨｹ 00ｨｨ010806ｨｺ09ｨｨ05-08ｨ 01ｨｨｨｺｨ 05 ｨｨ 09ｨｮ ｨｺ09ｨｨ01-ｨ ｨｪｨｨ06ｨｪ [8], ｨｰ06ｨｬ 09 ｨｪ0209ｨｺ0605ｨｹｨｺ06 08ｨ 04 ｨｪｨｨ04ｨｺ06ｨｬ060502ｨｺｨｮ050708ｨｪ0402 ｨ ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰ04: 09ｨｨｨｰｨ ｨｬｨｨｨｪ04 05 ｨｨ ｨｨ 05ｨｰ06ｨｬ 0605ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｰ ｨ ｨｺ02ｨｨ02ｨｦ, 09 ｨｺ06ｨｰ060806ｨｦ ｨ ｨｪ % 06ｨ ｨｴ02ｨｦ ｨ ｨｪｨｰｨｨ08ｨ 01ｨｨｨｺｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ [4] ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨ ｨｪ04 ｨｮ05ｨ 0905ｨｨ09ｨ ｨｰｨｹ ｨ ｨｺｨｰｨｨ09ｨｪ ｨｬ04 ｨｺｨｨ ｨ ｨｨ ｨ 0406ｨｰｨ ｨ 05ｨ ｨ ｨｨｨｬ ｨｺｨｰ0806ｨｪ06- ｨｨ ｨｰ06ｨｪ ｨｪ04ｨｬ ｨｦ09ｨｰ09ｨ ｨｬ, 06ｨ 08ｨ 04ｨｮ ｨｨ 05ｨｰ06ｨｬ 0002ｨｪ06ｨｺ09ｨｨ05-08ｨ 01ｨｨｨｺｨ 05, ｨ ｨｰｨ ｨ ｨｨ05ｨｹｨｪ04ｨｦ, ﾂ02ｨｬ ｨ ｨｪｨ ｨｨ ﾂｨｪ ｨ 01ｨｨｨｺｨ 0504 ｨｨ04 ｨｬ06ｨｪ06ｨｬ0208ｨｪ ｨ 0906ｨｪ06ｨｨ [11]. 0004ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ02 05ｨｰ ｨｪ06ｨｺ09ｨｨ05-08ｨ 01ｨｨｨｺｨ 05ｨ ｨｮ00ｨｨｨｬｨｨ ｨ 0601ｨｪ04ｨｬｨｨ 08ｨ 01ｨｨｨｺｨ 05ｨ ｨｬｨｨ 0708ｨｨ090601ｨｨｨｰ ｨｺ 06ｨ ｨｮ ｨｨ ｨ 0601ｨｪ0608ｨ 01ｨｨｨｺｨ 05ｨｹｨｪ ｨ ｨｨ05ｨｮ ｨｨｨｬ0208ｨｪ ｨ 08ｨ ｨｺｨｰ0208ｨ 01ｨｨｨｬｨｨ ﾂ0209ｨｺ ｨｰ080602ｨｪｨｨ07, ｨ ｨ ｨｰ0205ｨｹｨｪ06, 03ｨｨ0806ｨｺ ｨ 04ｨｪ0606ｨ 08ｨ 04ｨｨ07 00ｨｨ04ｨｨｨｺ06-01ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ ｨｦ09ｨｰ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609, ｨｨ01 ｨ ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰｨｪｨ 07 ｨｨ ｨ ｨｪｨｰｨｨ08ｨ 01ｨｨｨｺｨ 05ｨｹｨｪｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 04ｨ 09ｨｨ09ｨｨｨｰ 06ｨｰ ｨｰｨ ｨｺｨｨ01 00ｨ ｨｺｨｰ , ｨｺｨ ｨｺ 09ｨｰ020702ｨｪｨｹ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ, 00ｨ ｨｨ04ｨ 02ｨｨｨｨ (ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｰｨ ｨｰｨｺ ｨ ｨｦ ｨｺｨｨ090506ｨｰ04 09 ｨｬ060502ｨｺｨｮ0502), ｨｰ0906 ｨｺ ｨ 0205ｨｺｨ ｨｬ ｨｨ ｨｺ ｨｨ02ｨｨ02ｨｪｨｰ 08ｨ ｨｪｨｨ07 ｨｬ020301ｨｮ 05ｨｨ07ｨｨ01ｨｪ06ｨｦ ｨｨ ｨｪ06ｨｦ 00ｨ 04ｨ ｨｬｨｨ. 0308ｨｨ080601ｨ ｨｬ06ｨｪ06ｨｬ0208ｨｪ ｨｪｨｹ0209 ｨｨ ｨｪｨｨ02 ｨｬ0203ｨｬ06ｨｪ06ｨｬ0208ｨｪ ｨｦ 06ｨｺｨ ｨ 06ｨｰ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ ｨｨ07ｨｪｨｨ02 ｨｪｨ ｨ ｨｪｨｰｨｨ08ｨ 01ｨｨｨｺｨ 05ｨｹｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ. 06ｨ ｨｺ, 00ｨ ｨｨ04ｨ 02ｨｨ07 ｨｮ090205ｨｨ ﾂｨｨ09ｨ 02ｨｰ ｨ ｨｪｨｰｨｨ08ｨ 01ｨｨｨｺｨ 05ｨｹｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｪ06ｨｦ 00ｨ 0402, ｨｪ06 09ｨｪｨｨ03ｨ 02ｨｰ 09 05ｨｨ07ｨｨ01ｨｪ06ｨｦ [33]. 02ｨ ｨｪｨｪ ｨｨ07ｨｪｨｨ06 09ｨｰ020702ｨｪｨｨ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ ｨｪｨ ｨ ｨｪｨｰｨｨ08ｨ 01ｨｨｨｺｨ 05ｨｹｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｰｨ ｨｰ06 ﾂｨｪ ｨｰｨｨ ﾂｨｨ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨ ｨｪｨｰｨｨ08ｨ 01ｨｨｨｺｨ 05ｨｹｨｪｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｪ06ｨｦ 00ｨ ｨ 09ｨｰｨ 02ｨｰ 06ｨｰ ｨｬ06ｨｪ06ｨｬ ｨｺ 01ｨｨｨｬ0208ｨ ｨｬ ｨｨ ｨｰ08ｨｨｨｬ0208ｨ ｨｬ, 04ｨ ｨｰ02ｨｬ 09ｨｪｨｨ03ｨ 02ｨｰ0907 ｨｺ ｨｰ02ｨｰ08ｨ ｨｬ0208ｨ ｨｬ, 09 ｨｰ ｨｬ07 ｨｺｨ ｨｺ 09 05ｨｨ07ｨｨ01ｨｪ06ｨｦ 00ｨ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02ｨｬ 09ｨｰ020702ｨｪｨｨ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 07ｨ 01ｨ 02ｨｰ [33] ｨｮ05ｨｹｨｰｨ ｨｰ ｨｮ00ｨｨ01 ｨ 09ｨｰ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｰ 06ｨ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨｨｨ ｨ ｨｪｨｰｨｨ08ｨ 01ｨｨｨｺｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02ｨｬ 0605ｨｨ0006ｨｬ0208ｨｪ06ｨｦ ｨｨ 0708ｨｨ ｨｰ02ｨｺｨ ｨｪｨｨｨｨ 08ｨ 01ｨｨｨｺｨ 05ｨｹｨｪ ｨｨ07ｨｨ01ｨｪ ｨｬ02ｨｪｨ 01 [25]. 02ｨ 08ｨ ｨ ｨｪｨｨ02 ｨｺ06ｨｬ070502ｨｺ ｨ 0205ｨｺｨ ｨｬｨｨ ｨｰｨ ｨｺ ｨｨ0702ｨｰ ｨｪｨ ｨ ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609: ｨｮ ｨ ｨｺ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｺ06ｨｬ070502ｨｺ09ｨ 06ｨｪｨ ｨ 08ｨ 04ｨ ｨｪｨｨ0302, ﾂ02ｨｬ ｨｮ ｨ 0601ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609, 0708ｨｨ 05ｨｰ06ｨｬ 0202 ｨｮ ｨｪｨｹ ｨｮ 06ｨ 08ｨ ｨ ｨｺ06ｨｬ070502ｨｺ09ｨ 04ｨ 09ｨｨ09ｨｨｨｰ ｨｺｨ ｨｺ 06ｨｰ ｨｬ060502ｨｺｨｮ050708ｨｪ ｨｰ080602ｨｪｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ, ｨｰｨ ｨｺ ｨｨ 06ｨｰ ｨｰｨｨ07ｨ ｨ 0205ｨｺｨ [6]. 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 05ｨｰｨ ｨｪ ｨｰ09ｨｰ09ｨｮ02ｨｰ ｨ ｨｪｨｨ06 ｨ 0205ｨｺ0609 ｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609, ｨｮ090205ｨｨ ﾂｨｨ09ｨ 07 ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ ｨ ｨｨ ｨｰｨｮ07ｨｪ0609ｨｰｨｹ ｨｨ ｨ ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｪｨｨ01 [42] ｨｪ0608ｨｬｨ 05ｨｹｨｪ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ ｨ 09ｨｺ0608ｨ ｨｨｨｪ060906ｨｦ ｨｺｨｨ090506ｨｰ ｨ ｨｪｨｨ04ｨｬ02 06ｨ 08ｨ 04ｨｮ02ｨｰ0907 ｨ 09ｨｺ0608ｨ ｨ ｨｰ-08ｨ 01ｨｨｨｺｨ 05, ｨｺ06ｨｰ060804ｨｦ ｨｰ0907 ｨｨｨｪｨｨ02ｨｨｨ ｨｰ060806ｨｬ ｨ 0601ｨｪ0608ｨ 01ｨｨｨｺｨ 05ｨｹｨｪ ｨｪｨｨｨｬ ｨｨ04 ｨ ｨｺｨｰ0609 ｨ ｨｨ ｨｨ ﾂ0209ｨｺ ｨｦ09ｨｰ09ｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｰ0907 ｨｨ ｨ ｨｪ0609ｨｰｨｹ ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ ｨｰｨｹ ｨ 09ｨｺ0608ｨ ｨ ｨｰ-08ｨ 01ｨｨｨｺｨ 05 [16], ｨｰ09ｨｰ09ｨｮ07 ｨｨ09ｨｰ06ｨｴ02ｨｪｨｨ06 07ｨｮ05ｨ ｨ 09ｨｺ0608ｨ ｨｨｨｪ060906ｨｦ ｨｺｨｨ090506ｨｰ ｨ ｨｪｨｨ04ｨｬ ｨｬｨｨｨｬ06 05ｨｰ060006, ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04 04ｨ ｨｴｨｨｨｴｨ 06ｨｰ 06ｨｰ 06ｨｺ09ｨｨ01ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ 05ｨｪ ｨｪｨｪ0402 ｨｪｨｨ04ｨｺ06ｨｬ060502ｨｺｨｮ050708ｨｪ ｨ ｨｪｨｨ ﾂ0209ｨｺｨｨ02 ｨ ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰ04 ｨC ｨ 05ｨｹ00ｨ -ｨｰ06ｨｺ [27] ｨｨ ｨｰｨ ｨｰｨｨ06ｨｪ [36], ﾂｨｰ ｨｰ ｨｮ090205ｨｨ ﾂｨｨｨｰｨｹ ｨｨ09ｨｰ02ｨｬ04 ｨ ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰｨｪ06ｨｦ 04ｨ ｨｴｨｨｨｰ ｨ ｨｪｨｨ04ｨｬｨ. 09ｨｨ ｨｰｨｮ07ｨｪ0609ｨｰｨｹ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨ 03ｨｪ02ｨｦ03ｨｨｨｬ ｨ ｨｺｨｰ06ｨｬ ｨｪｨｨ07 ｨ ｨｨ ｨｨ ﾂ0209ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0506ｨ ｨ 08ｨ ｨｰｨ ｨｰ ｨ ｨｨ ｨｰｨｮ07ｨｪ0609ｨｰｨｹ. 08ｨ ｨ 02ｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｮ0106 ﾂｨｪ06-ｨｺｨｨ0302 ﾂｨｪ06ｨｬ ｨｰ08ｨ ｨｺｨｰ02 04ｨ 09ｨｨ09ｨｨｨｰ 06ｨｰ ｨｨ01 ｨｬ060502ｨｺｨｮ050708ｨｪ ｨ. In vitro 09 ｨｨ ｨｹ040609ｨ ｨｪｨｨ02ｨｬ ｨｬ06ｨｪ ｨｺ0502ｨｰ06ｨｺ ｨｰ06ｨｪｨｺ ｨｺｨｨ0302 ﾂｨｪｨｨｨｺｨ ﾂ ｨｺｨ ｨｬ06ｨｪ06ｨｬ020804, 01ｨｨｨｬ ｨｨ ｨｰ08ｨｨｨｬ ｨ ｨ ｨ ｨｨ080609ｨ 05ｨｨ09ｨｹ ｨｨｨｪｨ ｨｺ060906ｨｦ 09ｨｺ ｨｰｨｹ06 [38]. 0308ｨｨ 05ｨｰ06ｨｬ 0706ｨｰ06ｨｺ ｨ ｨ ｨ 02ｨｨｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｨ09ｨｰ08ｨｨ080609ｨ ｨｪｨ ｨｮ080609ｨｪ02 ｨｬｨ ｨｪｨｪｨｨｨｰ0605ｨ ｨC 00ｨｨ ｨｨ05ｨｹｨｪ ｨｬｨ 08ｨｺ0208ｨ ｨｪ02ｨｦ ｨｨｨｬ0609ｨｰｨｨ ｨｰ06ｨｬｨｮ ｨｪ ｨｰｨｪ06, ﾂｨｰ06 ｨ ｨｨ ｨｰｨｮ07ｨｪ0609ｨｰｨｹ 01ｨｨｨｬ ｨｨ ｨｰ08ｨｨｨｬ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ﾂ ｨｮ0106 ﾂｨｪ06-ｨｺｨｨ0302 ﾂｨｪ04ｨｦ ｨｰ08ｨ ｨｺｨｰ ｨｰｨ 09ｨｨｨｬｨ 09 ｨ ｨ ｨ 02ｨｨ02ｨｦ ｨｺｨ ｨｰ0201ｨｨｨｪ ｨｨ0006ｨｬ ｨｪ02ｨｦ 09ｨｰ020702ｨｪｨｹ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｪ02 ｨ ｨ ｨ ｨｨ080609ｨ 05ｨｨ09ｨｹ ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｬ ｨｬ06ｨｪ ｨｬ ｨｹ03ｨ 07 85

6 13 ﾂｨ 09ｨｰｨｹ 0008ｨ ｨｺ02ｨｨｨｦ ｨｨｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｨ ﾂｨ 09ｨｰｨｨ ﾂｨｪ06 ｨｰ08ｨｨｨｬ0208ｨ 052 ｨ 0405ｨ ｨ ｨｪｨ 09 ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ 04ｨ 09 ﾂ02ｨｰ 06ｨ 08ｨ ｨ ｨｪｨｨ07 ｨｺ06ｨｬ070502ｨｺ ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ04ｨｬｨｨ ｨ 0205ｨｺｨ ｨｬｨｨ [38]. 00 ｨｮ ｨｨ0701 in vivo, 0601ｨｪｨ ｨｺ06, ｨ ｨｨ ｨｰｨｮ07ｨｪ0609ｨｰｨｹ ｨｨｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｬ060302ｨｰ ｨ 09ｨｰｨ ｨｰｨｹ ｨｮ 0708ｨｨ ﾂｨｨｨｪ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ ｨｨ09ｨｺｨｮ0909ｨｰ0902ｨｪｨｪ ｨｮ0106 ﾂｨｪ ｨｺｨ ｨｪｨ ｨ ｨ 02ｨｰ0907 ｨ 0409ｨｰ08ｨ ｨｺ06ｨｬ070604ｨｨ02ｨｨ ｨｨｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｺ09ｨ ｨｬ ｨｪｨ ｨｬ06ｨｪ06ｨｬ ｨｨ 01ｨｨｨｬ [43], ｨｺ06ｨｰ ｨｺ06 ｨ ｨ ｨ ｨｨ08ｨｮ06ｨｰ ｨｰ02ｨｪｨｺｨ ｨｬｨｨ ｨｺｨｨ0302 ﾂｨｪｨｨｨｺｨ. 05ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ04ｨｦ 09ｨｺ05ｨ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 ｨ ｨｨ ｨｰｨｮ07ｨｪ0609ｨｰｨｨ ｨｨｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｬ060302ｨｰ 09ｨｪ0609ｨｨｨｰｨｹ ｨｨ ｨｺｨｨ0302 ﾂｨｪｨ ｨ, ｨｺ06ｨｰ0608ｨ ｨ ｨｪｨ ｨｺｨ ｨｰｨ ｨ 0605ｨｨ04ｨｨ080609ｨ ｨｰｨｹ ｨｨｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04 09 ｨｪｨｨ04ｨｺ06ｨｬ060502ｨｺｨｮ050708ｨｪ ｨｪ0605ｨｹｨｪ0402 ｨｺｨｨ090506ｨｰ04 [17]. 0308ｨｨ ｨｦ09ｨｰ09ｨｨｨｨ in vitro ﾂ ﾂ0209ｨｺ06ｨｦ 0002ｨｺｨ 05ｨｹｨｪ06ｨｦ ｨｪｨ 09ｨｬ0209ｨｹ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｰ020702ｨｪｨｹ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ 6 ｨｨ ｨ 0601ｨｪ06ｨｦ 06ｨｰ 01ｨｨｨｬ ｨ 0405ｨ 06ｨ ｨｪｨ 08ｨｮ0302ｨｪｨ ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪｨ 07 (ｨｪｨ 90%) ｨ 01ｨ 02ｨｨ07 09ｨｬ0209ｨｨ. 00 ｨｺｨ ﾂ0209ｨｰ ｨｪ0609ｨｪ ｨｬ02ｨｰｨ ｨ 0605ｨｨｨｰｨ ｨｪｨ 3-(m-00ｨｨ010806ｨｺ09ｨｨ0002ｨｪｨｨ05) ｨｨ06ｨｪ0609ｨ 07 ｨｺｨｨ090506ｨｰｨ, ｨ 09 ｨｬ02ｨｪｨｹ03ｨｨ01 ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ p-00ｨｨ010806ｨｺ09ｨｨ0002ｨｪｨｨ ｨｦ ｨｨ0406ｨｬ0208 ｨｨ ｨｮ00ｨｨ ｨｪ0605ｨｹｨｪ0401 ｨｺｨｨ090506ｨｰ [40], ｨｺ06ｨｰ ｨ ｨｪ ｨｪｨｨｨｺｨ ｨｰｨｹ ﾂ ｨｨ04ｨｨ09ｨｰｨｮ06 ｨｺｨｨ0302 ﾂｨｪｨｨｨｺｨ. 05ｨｨ09ｨｰ02ｨｬｨｪ ｨｺｨｰ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｬｨｬｨｮｨｪ06ｨｬ0601ｨｮ05ｨｨ08ｨｮ06ｨｴ ｨｦ09ｨｰ09ｨｨ ｨｹ03ｨｨｨｪ09ｨｰ0906 ｨｨ ｨｪ0609ｨｪ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｮ050702ｨｨｨｨ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ04 ｨｺ ｨ ｨ 05ｨ ｨｪ09ｨｮ ｨｬ020301ｨｮ 06ｨｺ09ｨｨ01ｨ ｨｪｨｰｨ ｨｬｨｨ ｨｨ ｨ ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰｨ ｨｬｨｨ ｨｴｨｨ02 09ｨｰｨ 01ｨｨｨｨ 09 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ08ｨ ｨｪ0901ｨｮｨｺ02ｨｨｨｨ, ｨｰｨ ｨｺｨｨ02 ｨｺｨ ｨｺ ｨｨ05ｨｨ080609ｨ ｨｪｨｨ02 ｨ 0205ｨｺ0609 ｨｨ ｨ ｨｪｨｨ02 00ｨ ｨｺｨｰ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ ｨｪｨ , ｨｬ0601ｨｮ05ｨｨ08ｨｮ06ｨｰ ｨｪｨｮｨｰ08ｨｨｨｺ0502ｨｰ06 ﾂｨｪ04ｨｬ 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ04ｨｬ 0706ｨｰ02ｨｪ02ｨｨｨ 0506ｨｬ. 06ｨｺ ｨｨｨｬ02ｨｪｨｰ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ ｨｬｨｨ 0706ｨｺｨ 04ｨ 05ｨｨ ｨｨ ｨ ｨｪ0609ｨｰｨｹ 01ｨｨ ｨｪ02ｨｨ080609ｨ ｨｪｨｪ ｨｨ07ｨｰｨｹ ｨｪｨ 05ｨｺ ｨｨ ｨｪ ｨｺｨｮ05ｨｹｨｰｨｮ0802 ｨｺ0502ｨｰ06ｨｺ, ｨｬ0601ｨｮ05ｨｨ080609ｨ ｨｰｨｹ ｨｨｨｬｨｬｨｮｨｪｨｪ04ｨｦ 06ｨｰ0902ｨｰ 09 ｨｬｨ ｨｺ080600ｨ 00ｨ 01, 09ｨｰｨｨｨｬｨｮ05ｨｨ08ｨｮ ｨｪｨｨ02 ｨ 05ｨｹ00ｨ -00ｨ ｨｺｨｰ0608ｨ ｨｪ02ｨｺ080604ｨ 0607ｨｮ ｨｦ [32] ｨｰｨｬ02 ﾂ02ｨｪ06 ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ06ｨｴ ｨｨ07ｨｪｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609, ｨｪｨｪ0401 ｨｨ04 ｨｺ ｨｬ060809ｨｺ06ｨｦ ｨｪ04 Pinus maritima, ｨｪｨ 06ｨ 08ｨ ｨ ｨｪｨｨ02 06ｨｺ09ｨｨ01ｨ ｨ 0406ｨｰｨ (NO) 09 ｨｬｨ ｨｺ080600ｨ 00ｨ 01 [45], ﾂｨｰ06 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 06ｨ ｨｮ ｨｪ06 ｨｺｨ ｨｺ ｨｪ ｨｰ0902ｨｪｨｪ04ｨｬ 0905ｨｨ07ｨｪｨｨ02ｨｬ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｪｨ ｨｰ02ｨｺｨ ｨｪｨｨ02 09ｨｪｨｮｨｰ08ｨｨｨｺ0502ｨｰ06 ﾂｨｪ , ｨｰｨ ｨｺ ｨｨ ｨ ｨｪｨｪ04ｨｬ ｨC ﾂ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ ｨｨ ｨｨ09ｨ 01ｨ 08ｨｨ01ｨ ｨｬｨｨ [7]. 05ｨｰ020702ｨｪｨｹ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｰｨ ｨｺ0302 ｨｨ0008ｨ 05ｨ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪｨｮ ｨｹ 09 ｨｪｨ 0708ｨ ｨｪｨｪ0609ｨｰｨｨ ｨｺｨｰｨ ｨｨ 01ｨｨｨｬ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｨ ｨｨ ｨｪ0606 ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ06ｨｴｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0708ｨｨ 06ｨ 08ｨ ｨ ｨｪｨｨｨｨ NO, ｨｰ06 ｨｰ08ｨｨｨｬ ｨｨ 09ｨｮｨｬｨｬｨ 08ｨｪ04ｨｦ 05ｨｺ09ｨｰ08ｨ ｨｺｨｰ 0003ｨｨｨｺｨｪ060002ｨｪ060503, ｨｨｨｬ0206ｨｴｨｨｨｦ ｨｪ02ｨｬ ｨ ｨｺｨｮ06, ﾂ02ｨｬ 2, 09ｨｰ020702ｨｪｨｹ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ, 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 ｨｮ090205ｨｨ ﾂｨｨ09ｨ 05ｨｨ 06ｨ 08ｨ ｨ ｨｪｨｨ02 NO, ｨｨｨｪｨｨ02ｨｨｨｨ08ｨｮ02ｨｬ0602 ｦﾃ-ｨｨｨｪｨｰ ｨｪ06ｨｬ [32] ｨ ｨ 06ｨｰ 0706ｨｺｨ 04ｨ ｨｪ ｨｨ07ｨｪｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｪｨ 05ｨｺ ｨｨ06 ｨｨ 0902ｨｺ080202ｨｨ06 ｨｨｨｪｨｰ ｨｦｨｺｨｨｨｪｨ -1ｦﾂ 09 ｨｬ06ｨｪ ｨｪ0401 ｨｺ0502ｨｰｨｺｨ ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｺ080609ｨｨ [15]. 0205ｨｨ0006ｨｬ ｨｰ020702ｨｪｨｹ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ ｨｪｨｨ03ｨ 05ｨｨ 05ｨｺ ｨｨ ｨｪｨ ｨｨｨｪｨｰ ｨｦｨｺｨｨｨｪｨ -1ｦﾂ, ｨ ｨｰ020702ｨｪｨｹ06 5ｨC10 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 ｨｮ090205ｨｨ ﾂｨｨ09ｨ 05ｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04, ｨｪｨｪ0402 ｨｨ04 ｨｺｨ ｨｺｨ 06, ｨｰ09ｨｰ090609ｨ 05ｨｨ ｨｨ000208ｨ 02ｨｨｨｨ 05ｨｨｨｬ000602ｨｨｨｰ0609 ｨｨ 06ｨ 08ｨ ｨ ｨｪｨｨ06 IGG 09 06ｨｰ0902ｨｰ ｨｪｨ ｨｬｨｨｨｰ060002ｨｪ 00ｨｨｨｰ060002ｨｬｨ ｨｰｨｨｨｪｨｨｨｪ. 0201ｨｪｨｨｨｬ ｨｨ04 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609 ｨ ｨｪｨｰｨｨ ｨ 05ｨｨｨｰ0205ｨｹｨｪ ｨｦ09ｨｰ09ｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ02 ｨ ｨｨｨｨ 05ｨｨｨｬ000602ｨｨｨｰ0609 ｨｺ ｨｺｨ 0806ｨｰｨｨｨｪ0602ｨｨｨｰｨ ｨｬ, ｨｨｨｪ01ｨｮ02ｨｨ080609ｨ ｨｪｨｪ0602 IGG [10]. 00 ｨｮ ｨｨ0701 ｨｨｨｬｨｬｨｮｨｪｨｪ ｨｨ02ｨｨｨｰｨ ｨｮ ｨｬ040302ｨｦ, ｨ ｨｪｨｪ ｨ 0302ｨｪｨｨ02ｨｬ 0802ｨｰ080609ｨｨ08ｨｮ0906ｨｬ LP-BM5, ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ04 09ｨｪｨｨ03ｨ 05ｨｨ 0106 ｨｪ0608ｨｬ ｨｪｨｪ04ｨｦ ｨｮ ｨｪｨｹ ｨｨｨｪｨｰ ｨｦｨｺｨｨｨｪｨ -6, ｨ 0708ｨｨ ｨｪｨｨ ﾂ0209ｨｺ06ｨｬ ｨｮ0706ｨｰ0802ｨ 0502ｨｪｨｨｨｨ 05ｨｰｨ ｨｪ0605ｨ ｨC ｨｨｨｪｨｰ ｨｦｨｺｨｨｨｪｨ ｨｬ02 ｨｰ060006, 06ｨｪｨｨ ｨｮ090205ｨｨ ﾂｨｨ09ｨ 05ｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｺ0502ｨｰ06ｨｺ-ｨｺｨｨ [14]. 0005ｨｨ07ｨｪｨｨ02 ｨｪｨ ﾂｨｪ ｨｮ01ｨｨ09ｨｰｨｮ06 09ｨｨ09ｨｰ02ｨｬｨｮ. 0201ｨｪｨｨｨｬ ｨｨ04 ｨｪｨ ｨｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｪ0401 ｨ ｨｺｨｰ0609 ｨ ｨｨ ｨｨ ﾂ0209ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｰ0907 ｨｨ ｨｨ07ｨｪｨｨ02 ｨｪｨ 08ｨ 0405ｨｨ ﾂｨｪ0402 ｨｮ ﾂｨ 09ｨｰｨｺｨｨ ﾂｨｪ ｨｮ01ｨｨ09ｨｰ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ ｨｨ0102ｨｬｨｨ ｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ ｨ ｨｪｨｨ07, ｨｪｨｪ ｨｰ08ｨ ｨｪｨ 01, ｨｪｨ ｨｪｨｨ02 ｨｺ06ｨｰ ｨｰ08ｨ 01ｨｨ02ｨｨ06ｨｪｨｪ06 ｨｮ0706ｨｰ0802ｨ ｨｰ ｨ 0605ｨｹ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｺ08ｨ 09ｨｪ ｨｨｨｪｨ, 0706ｨｺｨ 04ｨ 05ｨｨ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 09ｨｪｨｨ0302ｨｪｨｪ04ｨｦ ｨｮ ｨｪｨｹ 09ｨｬ0208ｨｰｨｪ0609ｨｰｨｨ 06ｨｰ ﾂｨｪ ｨｮ01ｨｨ09ｨｰ ｨ ｨ ｨ ｨｪｨｨｨｦ, ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ 01ｨｨ02ｨｰｨｮ ｨｺｨｨｨｬ ｨ ｨｪｨｨ02ｨｬ ｨｪｨ 0904ｨｴ02ｨｪｨｪ ｨｨ ｨ ｨｪｨｪ ｨｪｨｨ ｨｮ ﾂｨｨ

7 13ｨｪｨ 0409ｨ ｨｪｨｨ ｨ ｨｪ02ｨｮ0409ｨｺ ｨ 08ｨ 0106ｨｺ09ｨ ｨｰ0802ｨ 0502ｨｪｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｨ 09ｨｨｨｪ, ｨ 0600ｨ ｨｰ ｨｨ0002ｨｪ0605ｨ ｨｬｨｨ, ｨ ｨｪ ｨｪｨｨ0302ｨｪｨｨ02ｨｬ ｨ 00ｨ ｨｺｨｰ ｨｨ09ｨｺｨ 08ｨ 0409ｨｨｨｰｨｨ ﾂｨｪ ｨｮ01ｨｨ09ｨｰ ｨ ｨ ｨ ｨｪｨｨｨｦ, ｨｰｨ ｨｺｨｨ01 ｨｺｨ ｨｺ ｨｪｨｪ0602 ｨｺ ｨｪ ｨ ｨｪｨｨ02 ｨｨ ｨｮ090205ｨｨ ﾂ02ｨｪｨｪ04ｨｦ ｨｮ ｨｪｨｹ ｨｰ0208ｨｨｨｪｨ 09 ｨｺ080609ｨｨ [35]. 0209ｨｪ0609ｨｪ0402 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ04, 06ｨ ｨｮ ｨｨ09ｨ 06ｨｴｨｨ02 04ｨ ｨｴｨｨｨｰｨｪ ｨｦ09ｨｰ09ｨｨ ｨｨ0002ｨｪ0605ｨｹｨｪ ｨｺ06ｨｬ070502ｨｺ09ｨ ｨｺ08ｨ 09ｨｪ ｨｨｨｪ, 09ｨｺ0506 ﾂｨ 06ｨｰ ｨ 07 04ｨ ｨｴｨｨｨｰｨｮ 06ｨｰ 06ｨｺ09ｨｨ01ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨｬ0601ｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ 05ｨｨ ｨｰ02ｨｨｨｪ0609 ｨｪｨｨ04ｨｺ06ｨｦ ｨｰｨｪ0609ｨｰｨｨ ( ) [30], ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ02 ｨ ｨ 02ｨｨｨｨ ｨｰ0806ｨｬｨ 0602ｨｨｨｰ0609 [13] ｨｨ 09ｨｰｨｨｨｬｨｮ050702ｨｨ ｨｺ080202ｨｨｨｨ 05ｨｪ0106ｨｰ0205ｨｨｨ 05ｨｹｨｪ ｨｺ09ｨｨ01ｨ ｨ 0406ｨｰｨ [9] ｨｰ0802ｨ 0502ｨｪｨｨ02 ｨｺ08ｨ 09ｨｪ ｨｨｨｪｨ [18], ｨｨ0002ｨｪ0605ｨｹｨｪ ｨｺ06ｨｬ070502ｨｺ09ｨ ｨｺ08ｨ 09ｨｪ ｨｨｨｪｨ [12] ｨｨ05ｨｨ 0102ｨ 05ｨｺ ｨｨ04ｨｨ080609ｨ ｨｪｨｪ ｨｺ08ｨ 09ｨｪ ｨｨｨｪｨ [41] ｨｮ090205ｨｨ ﾂｨｨ09ｨ 0506 ｨ ｨｪｨｰｨｨ06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0705ｨ 04ｨｬ04 ｨｺ080609ｨｨ ｨｪ ｨｰ0902ｨｪｨｪ ｨｨ02ｨｬｨ, ｨ ｨ ｨ 04ｨ 05ｨｹｨｪｨｮ06 ｨ ｨｪｨｰｨｨ06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0705ｨ 04ｨｬ04 ｨC ｨｮ050708ｨｪ ｨｰ0802ｨ 0502ｨｪｨｨ ﾂ02ｨｰ ｨｪ ｨｹ ｨｪｨｨ07 ｨ ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0705ｨ 04ｨｬ04 ｨｪ02 ｨｪｨ ｨ ｨ ｨｹ ｨｨ07ｨｪｨｨ02ｨｬ ｨ ｨｨｨｪｨ [41] ｨｨ05ｨｨ ｨｺｨｨ [48], ｨｺ06ｨｰ ｨｨｨ 06 ｨｪ ｨ ｨｰ, 05ｨｨｨ ｨ ｨｰ ｨｪ02ｨ 0605ｨｹ ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｨ0002ｨｪ ｨｪｨｨｨｬ ｨｨ04 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ ｨ ｨｴｨｨｨｰ ｨｰ 06ｨｺ09ｨｨ01ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨｬ0601ｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｨｨｪｨｰ020008ｨ 02ｨｨ07 ｨｬ060502ｨｺｨｮ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｨ 04ｨ ｨｴｨｨｨｰｨ ｨｪ02ｨｪｨ 0904ｨｴ02ｨｪｨｪ06ｨｦ 03ｨｨ08ｨｪ06ｨｺｨｨ090506ｨｰｨｪ06ｨｦ ｨｰｨ ｨｴ02ｨｦ ｨｰ08ｨｨ0005ｨｨ020208ｨｨ ｨｨ ｨｰｨ 0902 [21]. 0208ｨｮ00ｨｨｨｬ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ06ｨｬ, ｨｰ0906ｨｬ ｨｺ06ｨｰ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨ ｨｪ ｨｰ09ｨｰ090609ｨ ｨｰｨｹ 08ｨ 0409ｨｨｨｰｨｨ ﾂｨｪ ｨｮ01ｨｨ09ｨｰ ｨ ｨ ｨ ｨｪｨｨｨｦ, ｨｰ0907 ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ02 ｨ ｨ 02ｨｨｨｨ ｨｰ0806ｨｬｨ 0602ｨｨｨｰ ｨ ｨｺ, ｨｮ ｨｺ ｨｺ08ｨ 09ｨｪ ｨｨｨｪ06 ｨｨ 0102ｨ 05ｨｺ ｨｨ04ｨｨ080609ｨ ｨｪｨｪ0602 ｨｺ08ｨ 09ｨｪ ｨｨｨｪ06 ｨｮ090205ｨｨ ﾂｨｨ09ｨ ｨｬ ｨｰ0409ｨ ｨｪｨｨ07 ｨｺ080609ｨｨ ｨｨ ｨｮｨｬ02ｨｪｨｹ03ｨ ｨ 04ｨｬ0208 ｨｰ0806ｨｬｨ ｨ, ｨ ｨｰｨ ｨｺ0302 ｨ ｨｨ06 ｨｰ0806ｨｬｨ 0602ｨｨｨｰ0609 ｨｺ ｨｺ060505ｨ 0002ｨｪｨｮ [46] ｨｨｨｪ06 ｨｨ 05ｨｰｨｨ ｨｦ 0907ｨｨ08ｨｰ ｨｰｨ ｨｺ ｨｦ09ｨｰ09ｨｨ07 ｨｪ02 06ｨｺｨ ｨ 05ｨｨ. 0606ｨｰ 00ｨ ｨｺｨｰ, ﾂｨｰ06 ｨｮ0706ｨｰ0802ｨ 0502ｨｪｨｨ02 06ｨ 0204ｨｹ07ｨｪｨ ｨｬｨｨ ｨ ｨｹ09ｨｨｨｪ ｨｨ ｨｦ070008ｨｮｨｺｨｰ ｨｺ0609, ｨ 0600ｨ ｨｰ0401 ｨ ｨｨ060005ｨ 0906ｨｪ06ｨｨ01ｨ ｨｬｨｨ, ｨｪ ｨ 09ｨｰ090609ｨ ｨｪｨｨ0302ｨｪｨｨ06 09ｨｺ ｨｰｨｨ ｨｺ060505ｨ 0002ｨｪ-ｨｨｨｪ01ｨｮ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨ ｨ 02ｨｨｨｨ ｨｰ0806ｨｬｨ 0602ｨｨｨｰ0609, 09 06ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ 09ｨｨｨｪ060008ｨ 01ｨｪ ｨｺｨ [31], ｨｰ ｨ 02ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0005ｨ 0906ｨｪ06ｨｨ ｨｨｨｬ02ｨｪｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ060906ｨｦ 0008ｨｮ ｨｹ04ｨｮ 05ｨｰ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ ｨｨ ｨ ｨｪ0609ｨｰｨｹ 09ｨｮｨｬｨｬｨ 08ｨｪ06ｨｦ ｨｨ0002ｨｪ0605ｨｹｨｪ06ｨｦ 0008ｨ ｨｺ02ｨｨｨｨ 09ｨｨｨｪ060008ｨ 01ｨ ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｰｨｹ ｨｰ0806ｨｬｨ ｨｨｨｪｨｨｨｪ01ｨｮ02ｨｨ080609ｨ ｨｪｨｪｨｮ06 ｨ ｨ 02ｨｨ06 ｨｰ0806ｨｬｨ 0602ｨｨｨｰ0609 ｨｮ ｨｺ [47]. 05ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ04ｨｦ 09ｨｺ05ｨ ｨ ｨｨ ｨｨ ﾂ0209ｨｺ ｨｦ09ｨｰ09ｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｪｨ ﾂｨｪ ｨｮ01ｨｨ09ｨｰｨｮ06 09ｨｨ09ｨｰ02ｨｬｨｮ 09ｨｪ0609ｨｨｨｰ ｨｨ ｨｨ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ ｨｮ01ｨｨ09ｨｰ06ｨｦ 09ｨｰ02ｨｪｨｺ06ｨｦ. 00ｨｨｨｪ060008ｨ 01ｨｪ0602 ｨｺ08ｨ 09ｨｪ ｨｨｨｪ06, ｨｨ0002ｨｪ0605ｨｹｨｪｨ ｨ ｨｺ02ｨｨ07 ｨｺ08ｨ 09ｨｪ ｨｨｨｪｨ, ｨ ｨｰｨ ｨｺ ｨｺ09ｨｰ08ｨ ｨｺｨｰ ｨｺ ｨｪ ｨ 05ｨｨ 05ｨｪ0106ｨｰ0205ｨｨｨｦ-04ｨ 09ｨｨ09ｨｨｨｬｨｮ ｨ ｨｺ09ｨ 02ｨｨ06 ｨｨ040605ｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨ 0608ｨｰ04 ｨｺ in vitro [20]. 0808ｨ ｨｺ02ｨｨ ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨ 0405ｨ ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨ ｨｺｨ ｨｺ ｨ ｨｺｨｰｨｨ09ｨｪ04ｨｦ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ 05ｨｺ09ｨｰ08ｨ ｨｺｨｰｨ, 06ｨ ｨｮ ｨｨ09ｨ 06ｨｴｨｨｨｦ ｨｪｨ ｨ ｨ 02ｨｬｨｮ06 05ｨｪ0106ｨｰ0205ｨｨｨ 05ｨｹｨｪｨｮ ｨ ｨｺ09ｨ 02ｨｨ ｨｺ0605ｨｹｨｺｨｮ 0601ｨｪｨｨｨｬ ｨｨ04 05ｨｪ ｨｪｨｪ0401 ｨｬ0201ｨｨｨ ｨｰ ｨｮ01ｨｨ09ｨｰ06ｨｦ ｨ ｨｺ09ｨ 02ｨｨｨｨ ｨｰ0907 NO, ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ-06ｨ ｨｮ ｨｪｨｪ ｨｦ09ｨｰ09ｨｨ02 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨ ｨｪ06 ｨｺｨ ｨｺ ｨｮ05ｨ 0905ｨｨ09ｨ ｨｪｨｨ02ｨｬ 09ｨｮ ｨｺ09ｨｨ01ｨｪ ｨ 01ｨｨｨｺｨ , ｨ 06ｨｴｨｨ01 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06 NO, ｨｰｨ ｨｺ ｨｨ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ02ｨｦ ｨ ｨｨ0609ｨｨｨｪｨｰ0204ｨ ｨｺｨｰｨｨ0904 ｨｨ ｨｹ040609ｨ ｨｪｨｨ ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｺ ｨｺ02ｨｨｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ, ｨ 02ｨｬ0401 ｨ 05ｨｺ ｨｬ ｨｰｨｪ06, ﾂｨｰ06 05ｨｰｨ ｨｪ ｨｪ0609ｨｰｨｹ06 ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｨ08ｨｮ02ｨｰ ｨ ｨｪｨｨ04ｨｬ02, 0708ｨｨ ﾂ02ｨｬ ｨｪ02 ｨｬ02ｨｪ % 05ｨｰｨ ｨｪ0605ｨ 06ｨｺｨｨ ｨｰ ﾂ02ｨｪｨｨ, 09 ｨｮ ﾂｨ 09ｨｰｨｨ02ｨｬ 0109ｨｮ ｨｪ0609ｨｪ ｨｬ02ｨｪｨｰ0609: ｨ 05ｨｺ ｨｹ010200ｨｨ ｨｪｨ 0404 (080201) ( ) ｨｨ ｨ 05ｨｹ010200ｨｨ ｨｨ ｨｪｨ 0404 ( ) ( ). 02ｨ ｨ ｨｬ02ｨｪｨｰｨ 09 ｨｺｨ ﾂ0209ｨｰ0902 ｨ ｨｺ020207ｨｰ0608ｨ 01 + ｨｨ ｨｹ04ｨｮ06ｨｰ , ｨｰ06ｨｬｨｮ 06ｨｺｨｨ090502ｨｪｨｨ02 05ｨｰｨ ｨｪ0605ｨ ｨ 02ｨｰ0907 ｨｪｨ ｨｺ ｨｪｨｨ02ｨｬ ｨｰｨ ｨｪ ｨｪｨｪ06ｨｦ ｨｬ04 ( ) ｨｨ 09ｨｪｨｨ0302ｨｪｨｨ02ｨｬ ｨ ｨｪｨｨ07 06ｨｺｨｨ090502ｨｪｨｪ06ｨｦ. 06ｨｰ06 06ｨ 09ｨｰ0607ｨｰ0205ｨｹ09ｨｰ0906 ｨｨｨｬ0202ｨｰ 0708ｨｨｨｪ02ｨｨ07ｨｨｨ 05ｨｹｨｪ ｨｪｨ ﾂ02ｨｪｨｨ ｨｰ06ｨｺ09ｨｨｨｺ ｨｨ ﾂ0209ｨｺ06ｨｦ 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺｨｨ 05ｨｰｨ ｨｪ0605ｨ, ｨｺ06ｨｰ060804ｨｦ ｨ 02ｨｪ ｨ 0506ｨｺｨｨ080609ｨ ｨｰｨｹ /4 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｬ06ｨｴｨｪ0609ｨｰｨｨ 0702 ﾂ02ｨｪｨｨ. 06ｨｰ ｨｰｨ ｨｰ06 ﾂｨｪ06, ﾂｨｰ06ｨ ｨ ｨ ｨｨｨｰｨｹ 0506ｨ ｨｮ00ｨｨ02 ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ 09ｨ 03ｨｪ ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ , ｨｰ02ｨｺｨ 06ｨｴｨｨ02 09 ｨｨ ｨｹ040609ｨ ｨｪｨｨ02ｨｬ (ｨ ｨ ｨｪ04ｨｦ 0005ｨｨｨｺ0605ｨｨ04, 02ｨｨｨｺ ｨ 09ｨ, ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬ ｨｰ08ｨｨ0005ｨｨ020208ｨｨ ｨｨ 03ｨｨ08ｨｪ0401 ｨｺｨｨ090506ｨｰ ｨｨ ｨｰ.01.). 87

8 ｨｬ06ｨｰ0807 ｨｪｨ 09ｨ 03ｨｪ0609ｨｰｨｹ ｨ ｨｨ05ｨ ｨｺｨｰｨｨｨｺｨｨ ｨｨ 0502 ﾂ02ｨｪｨｨ07 ｨ 05ｨｺ ｨｹｨｪ06ｨｦ ｨ ｨｪｨｨ ｨｨ ｨ 0600ｨ ｨｰ04ｨｦ ｨｨ09ｨｰ0608ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｰ, 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｴｨｨｨｦ 06 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 ｨ 0605ｨｹ0302ｨｦ ｨ ｨ 09ｨｪ0609ｨｰｨｨ ｨｮ0706ｨｰ0802ｨ 0502ｨｪｨｨ07 ｨ 05ｨｺ ｨｹｨｪ0401 ｨｪｨ 07ｨｨｨｰｨｺ0609, ｨ ｨｴｨｨ ｨｨ080601ｨｪ0402 ｨｺ06ｨｬ070502ｨｺ ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 (09ｨｨｨｪ060008ｨ 01ｨｪ ｨｨｨｪ06, 07ｨ 0506 ﾂｨｪ04ｨｦ 09ｨｨ0108), 08ｨ ｨ 06ｨｰ, ｨｴｨ 06ｨｴｨｨ01 ｨｮ ﾂｨ 09ｨｰｨｨ02 05ｨｰｨｨ ｨｴ0209ｨｰ09 09 ｨｺ ｨｺｨｰｨｨ080609ｨｺ02 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ, ｨ 02ｨｬ0401 ｨ 05ｨｺ ｨｬ, 0709ｨｪ06 ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪ ｨｪｨ ｨｺ06 01ｨ 0302 ｨｨｨｬ0206ｨｴｨｨ ｨ ｨｺｨｰ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｰ 06ｨ ｨ ｨｺｨｰｨｨ09ｨｪ06ｨｬ 09ｨｺ0506 ﾂ02ｨｪｨｨｨｨ 0605ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬ ｨ 05ｨｺ ｨ ｨｪｨｨ04ｨｬ02 ﾂ ｨｺｨ ｨｨ 03ｨｨ0906ｨｰｨｪ ｨ ｨｺ, ｨｪｨ ｨ 05ｨｺ ｨｹｨｪ06ｨｦ ｨｬ ｨｨ ｨ 0302ｨｪｨｨ ﾂ02ｨｪｨｨ (010806ｨｪｨｨ ﾂ0209ｨｺｨｨｨｦ 05ｨｺ ｨｨｨｬ02ｨｪｨｰ) ｨ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｺ06ｨｬ070502ｨｺ ｨｨ0002ｨｪ ｨ ｨｪ02ｨｦ ( ｨ 07 ﾂｨ 09ｨｰｨｹ ｨｰｨｨ07, ｨ ｨｪｨｪｨ 07 06ｨｰ ) 09ｨｨｨｪ060008ｨ 01ｨ, ｨ ｨｴｨｨｨｦ 09 ｨｺｨ ﾂ0209ｨｰ0902 ｨ ｨｺｨｰｨｨ09ｨｪ ｨｪｨ ﾂｨ 05ｨ ｨｺ06ｨｬ070502ｨｺ ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609, ｨｪ0608ｨｬｨ 05ｨｨ040609ｨ ｨｺｨ 04ｨ ｨｰ0205ｨｨ 05ｨｨ07ｨｨ01ｨｪ ｨ ｨｬ02ｨｪｨ [2]. 02ｨｰｨｬ02 ﾂｨ 05ｨｨ ｨｰｨ ｨｪ ｨｪｨｨ02 05ｨｨ0706ｨｰ080607ｨｪ06ｨｦ ｨｨ 0500ｨｨ080606ｨ 08ｨ 04ｨｮ06ｨｴ02ｨｦ 00ｨｮｨｪｨｺ02ｨｨｨｨ 0702 ﾂ02ｨｪｨｨ ｨｨ, ｨｺｨ ｨｺ ｨｰ09ｨｨ02 05ｨｰ060006, ｨｺｨ ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ ｨｨ ｨ ｨｨ0609ｨｨｨｪｨｰ0204ｨ 05ｨｨ ｨｰ02ｨｨ ｨｨ0002ｨｪ ｨｨｨｪ060008ｨ 01ｨ ｨ 05ｨｨ 09ｨｪｨｨ0302ｨｪｨｨ ｨ ｨｪｨｨ07 ｨｰ08ｨｨｨ 02ｨｨ050005ｨｨ020208ｨｨｨｪ0609 ｨｨ ｨ 0601ｨｪ ｨｰ0208ｨｨｨｪｨ ﾂ02ｨｪｨｨ ｨｺ ｨ ｨ ｨ 05ｨ 09ｨｹ ｨｨ ﾂ02ｨｰｨｺ ｨ 0302ｨｪｨｪｨ 07 ｨｺ ｨｺ02ｨｨ07 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ ｨ 09ｨｪ ｨｨ07, ｨｪｨ 08ｨｮ03ｨ 02ｨｬ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ 05ｨｰｨ ｨｪ0605ｨ ｨｬｨ 05ｨｨ040609ｨ ｨｹ ｨ ｨｪｨｨ02 06ｨｺｨｨ090502ｨｪｨｪ ｨｬ ｨｺ ｨｬ02ｨｪｨｰ ｨｨ ｨｨ ｨｮ090205ｨｨ ﾂｨｨ09ｨ ｨｹ ｨｰｨｪ060302ｨｪｨｨ / , ｨｰ09ｨｨ02 ﾂ ｨｨ ｨｨ05ｨ 0802ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ ｨｨ ｨｪｨ 0404 ｨｨ 09ｨｪ07ｨｰｨｨ02 ｨｰｨｺｨ ｨｪ020906ｨｦ 00ｨｨ0706ｨｺ09ｨｨｨｨ [2] ｨｪ ｨｪｨ 0302ｨｦ 05ｨ ｨ 0608ｨ ｨｰ0608ｨｨｨｨ ｨ 0405ｨｨ ｨｮ ﾂ02ｨｪ ｨ 08ｨ ｨｰ04 ｨｨ ｨ ｨｪ02ｨｦ 01ｨ 05ｨｹｨｪ ｨｰ06 ﾂｨｪ ｨｨｨｪ060008ｨ 01ｨ (Vitis amurensis), ｨｺｨ 05ｨｨｨｪ04 (Viburnum opuli), 05ｨｨｨｬ06ｨｪｨｪｨｨｨｺｨ ｨｺｨｨｨｰｨ ｨｦ09ｨｺ (Schizandra chinensis), ｨ ｨｴｨｨ02 09 ｨｺｨ ﾂ0209ｨｰ0902 ｨ ｨｺｨｰｨｨ09ｨｪ ｨｪｨ ﾂｨ 05ｨ ｨｺ06ｨｬ070502ｨｺ ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609, 0506ｨｺｨ 05ｨｨ04ｨｮ06ｨｴｨｨｨｦ ｨ % 06ｨ ｨｴ02ｨｦ ｨ ｨｪｨｰｨｨ06ｨｺ09ｨｨ01ｨ ｨｪｨｰｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 09ｨｮｨｬｨｬｨ 08ｨｪ0401 ｨｨ ﾂ02ｨｪｨｨｨｦ [4]. 00 ｨｮ ｨｨ ｨｰ0806ｨｦ ｨ 05ｨｺ ｨｹｨｪ06ｨｦ ｨｨｨｪｨｰ06ｨｺ09ｨｨｨｺｨ 02ｨｨｨｨ ｨ ｨ ｨｪｨ 08ｨｮ0302ｨｪ ｨｺ ｨ 0302ｨｪｨｪ ｨ ｨｰ ｨｰ02ｨｺｨｰ0608ｨｪ ｨｦ09ｨｰ09ｨｨ ｨｮ0706ｨｬ07ｨｪｨｮｨｰ ｨ 08ｨ ｨｰ0609, ｨｺ06ｨｰ ｨ 03ｨ ｨｹ 09 ｨｪ0608ｨｬｨ 05ｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｨ0601ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ ｨｺｨ 04ｨ ｨｰ020502ｨｦ 05ｨｨ07ｨｨ01ｨｪ ｨｨ ｨｮ ｨｪ ｨ ｨｬ02ｨｪｨ, 09ｨｺ0506 ﾂｨ 07 ｨｮ ｨｪｨｹ ｨｪ02ｨｦｨｰ08ｨ 05ｨｹｨｪ0401 ｨｨ ｨｪ ｨｨ07ｨｨ010609, ｨｨ07ｨｨ01ｨｪ ｨ ｨｺ02ｨｨｨｦ ｨｨ 03ｨｨ08ｨｪ06ｨｺｨｨ090506ｨｰｨｪ04ｨｦ ｨｰｨ 09 ｨｬ02ｨｬｨ 08ｨ ｨｪ ｨ ｨｰ0602ｨｨｨｰ ｨｰｨｬ02 ﾂ02ｨｪ ｨｰｨ ｨｪ ｨｪｨｨ ｨ ｨｪｨｨ07 06ｨｺｨｨ090502ｨｪｨｪ ｨｬ ｨｺ ｨｬ02ｨｪｨｰ ｨｨ , ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ ｨｺ06ｨｪ ｨｪ0204ｨ ｨｨ 0005ｨｨｨｺ0605ｨｨ04ｨ [5]. 00 ｨｰ ｨｬ07 ｨｪ02ｨｺ06ｨｰ ｨ 09ｨｰ ｨｪ02 06ｨ ｨｪｨ 08ｨｮ03ｨｨ05ｨｨ 0905ｨｨ07ｨｪｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｪｨ 0706ｨｺｨ 04ｨ ｨｰ0205ｨｨ 05ｨｨ07ｨｨ01ｨｪ ｨ ｨｬ02ｨｪｨ 0708ｨｨ ｨｪｨｨ ﾂ0209ｨｺ06ｨｦ ｨ 05ｨｺ ｨｨ04ｨ 02ｨｨｨｨ, 06ｨｰｨｬ02 ﾂｨ 07, ｨｰ02ｨｬ ｨｪ02 ｨｬ02ｨｪ0202, 04ｨ ｨｴｨｨｨｰｨｪ ｨｨ07ｨｪｨｨ02 ｨｰｨ ｨｺ ｨｪｨ ｨｬ ｨｨ ﾂ0209ｨｺｨｨ ｨｺｨ 04ｨ ｨｰ0205ｨｨ 0702 ﾂ02ｨｪｨｨ [44]. 0201ｨｪｨｨｨｬ ｨｨ04 ｨｪｨ ｨｨｨ ｨｨｨｪｨｰ ｨｪ ｨ ｨｺｨｰ ｨｬ0603ｨｪ ｨｮ ﾂｨ 09ｨｰｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ 05ｨｰｨ ｨｪ0605ｨ ｨｰ ｨｨ07ｨｪｨｨ02 ｨｪｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 05ｨｰｨ ｨｪ060506ｨｺｨｨ ｨｴｨｨ ｨｬ02ｨｪｨｰ ｨ ｨｺ, 09 05ｨｺ ｨｨｨｬ02ｨｪｨｰｨ 01 in vivo ｨｨ07ｨｪｨｨ02ｨｬ 0605ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ0609 ｨｪｨ ｨ ｨ 05ｨ 09ｨｹ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ ｨｮｨｺｨｰｨ 04ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨ 05ｨｺ ｨｹ010200ｨｨ ｨｪｨ 0404 ｨｺｨ ｨｺ 0708ｨｨ 0105ｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨ 05ｨｺ ｨｨ04ｨ 02ｨｨｨｨ 03ｨｨ0906ｨｰｨｪ0401, ｨｰｨ ｨｺ ｨｨ 0708ｨｨ 0601ｨｪ06ｨｺ08ｨ ｨｰｨｪ06ｨｬ 0708ｨｨ02ｨｬ02 ｨ 05ｨｺ ｨｬｨｨ ｨｨ090704ｨｰｨｮ02ｨｬ04ｨｬｨｨ [3]. 08ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ 05ｨｹ010200ｨｨ ｨｨ ｨｪｨ ｨｪｨｨ04ｨｺ06ｨｦ 08 m ｨ ｨｪ0705ｨ 09ｨｹ ｨｪｨ ｨｮ080609ｨｪ02 ｨｨｨｪｨｰｨ ｨｺｨｰｨｪ ｨｺ06ｨｪｨｰ ｨｰ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ 06 04ｨ ｨｴｨｨｨｰ ｨｪ06ｨｦ ｨｨ04 09ｨ 03ｨｪ02ｨｦ03ｨｨ01 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ01 00ｨｮｨｪｨｺ02ｨｨｨｦ ｨ 05ｨｺ ｨｹ010200ｨｨ ｨｪｨ 0404 ( ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ ｨｰｨｹ ｨ 0202ｨｰｨ 05ｨｹ010200ｨｨ ｨｰｨ ｨｪ0605ｨ ), ｨｮ05ｨｹｨｰｨ ｨｰ02 ﾂ ｨｨ09ｨ 02ｨｰ0907 ｨｪｨｨ04ｨｺｨ 07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07 ｨ 0202ｨｰｨ 05ｨｹ010200ｨｨ01ｨ ｨC 0609ｨｪ0609ｨｪ ｨ ｨｺｨｰ0608ｨ 07ｨ ｨｰ060002ｨｪｨｪ0609ｨｰｨｨ ｨ 03ｨ 06ｨｴ ｨｦ09ｨｰ09ｨｨ07 05ｨｰｨ ｨｪ0605ｨ [3]. 02ｨ ｨｨｨｬ0206ｨｴｨｨ ｨ ｨｪｨｪ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ 06 ｨｰ06ｨｬ, ﾂｨｰ06 ｨｺ06ｨｬ070502ｨｺ ｨｨ0006ｨｬ0208ｨｪ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨｰ ｨｺ06ｨ ｨｺｨｰｨｨ09ｨｪ04ｨｬｨｨ ｨｨｨｪ02ｨｪｨｨ07ｨｬｨｨ, 06ｨ 05ｨ 01ｨ 06ｨｴｨｨｨｬｨｨ 03ｨｨ0806ｨｺｨｨｨｬ ｨｺｨｰ0806ｨｬ ｨ ｨｨ ｨｨ ﾂ0209ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ, ｨｺ06ｨｰ0608ｨ ｨｰ0907 ｨｨ ｨｨ0002ｨｪ0605ｨｹｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ0806ｨｦ ｨｺ ｨ ｨｪｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ ｨ 09ｨｰ02ｨｪｨｨ0701, 0008ｨｮｨｺｨｰｨ 01, ｨ 01 ｨｨ ｨ 01, ｨｰ08ｨ 01ｨｨ02ｨｨ06ｨｪｨｪ06 ｨｨ ｨｹ04ｨｮ02ｨｬ ｨｨｨｴｨｮ ﾂ ｨｺ06ｨｬ, ｨｰ ｨｨ01 ｨｺｨ ｨｺ ｨｪｨ ｨｨｨ ｨｮ0706ｨｰ0802ｨ ｨｬ04ｨｦ 09ｨｨ01 08ｨ 09ｨｰｨｨｨｰ0205ｨｹｨｪ ｨｨ0002ｨｪ0605ｨｹｨｪ ｨｨｨｪ02ｨｪｨｨｨｦ ｨｮ ﾂ02ｨｪｨｪ ｨ ｨｪｨｪ ｨｺ ｨｺ02ｨｨｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ ｨｬｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ 0708ｨｨ ｨ 05ｨｺ ｨｹｨｪ06ｨｦ ｨｨｨｪｨｰ06ｨｺ09ｨｨｨｺｨ 02ｨｨｨｨ 01ｨ 06ｨｰ 0609ｨｪ0609ｨ ｨｪｨｨ02 08ｨ 0909ｨｬｨ ｨｰ08ｨｨ09ｨ ｨｰｨｹ ｨｬ0603ｨｪ0609ｨｰｨｹ ｨｨ ｨｨｨｬ02ｨｪ02ｨｪｨｨ ｨｨ09ｨｰ02ｨｬ ｨｨ05ｨ ｨｺｨｰｨｨｨｺｨｨ ｨｨ 0802ｨ ｨ ｨｨ05ｨｨｨｰｨ 02ｨｨｨｨ 07ｨ ｨｰ0600ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨｰ0607ｨｪｨｨｨｦ, 08ｨ 0409ｨｨ09ｨ 06ｨｴｨｨ ｨｮ05ｨｹｨｰｨ ｨｰ02 ｨｮ0706ｨｰ0802ｨ 0502ｨｪｨｨ07 ｨ 05ｨｺ

9 ｨｬｨ ｨｪ ﾁｨｰ ｨｰｨｨ ｨｰｨ 09ｨｨｨｰｨｹ ｨｪ06ｨｬｨｮ 0102ｨｦ09ｨｰ09ｨｨ06 ｨ 05ｨｺ ｨ 01ｨｨ090609ｨｰ06ｨｺ: 02ｨ 05ｨｹ , ｨｮ03ｨｪ ｨ , 0806ｨｬ02ｨｪｨｺ , ｨｦ ﾂｨｮｨｺ ｨｨ ｨ ｨｪｨｨ ｨ 08ｨ ｨｰｨ ｨｪｨ ｨｪ02ｨｺ06ｨｰ ｨｺｨ 04ｨ ｨｰ0205ｨｨ ｨｮ ｨｪ ｨ ｨｬ02ｨｪｨ 09 08ｨ 04ｨｪ0401 ｨｮ ｨｨ ｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨ 05ｨｺ ｨｨ04ｨ 02ｨｨｨｨ ｨｺ // 00ｨ ｨｨ07: 02ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨ, ｨｰ09ｨ ｨｨ 0708ｨ ｨｺｨｰｨｨｨｺｨ 06ｨ ﾂ02ｨｪｨｨ ｨｹ ｨ 01ｨｨ090609ｨｰ06ｨｺ: 02ｨ 05ｨｹｨｪｨ ｨｮｨｺｨ, C. 150ｨC ｨｮ03ｨｪ ｨ , ｨｨｨｪ , 04ｨ 01ｨｬｨ ｨｪｨｨｨｪ ｨｮ050702ｨｨ07 ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ 05ｨｰｨｨ ｨｨ08ｨｰｨ ｨ ｨｪｨｨ04ｨｬ ｨｨ0006ｨｬ0208ｨｪ04ｨｬｨｨ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪｨ ｨｬｨｨ ｨｺｨ ｨｺ ｨ ｨｨ05ｨ ｨｺｨｰｨｨｨｺｨｨ ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺ ｨｦ09ｨｰ09ｨｨ07 // 01ｨｨ00ｨｨ02ｨｪｨ ｨｨ 09ｨ ｨｪｨｨｨｰｨ 08ｨｨ ｨC ｨｨｨｪ , 08ｨｮ03ｨｪ ｨ , 0806ｨｬ02ｨｪｨｺ ｨｪｨｰｨｨ08ｨ 01ｨｨｨｺｨ 05ｨｹｨｪｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ ﾂ02ｨｪｨｨｨｦ ｨｨ04 01ｨ 05ｨｹｨｪ ｨｰ06 ﾂｨｪ ｨ 09ｨｰ02ｨｪｨｨｨｦ, ｨ ｨｴｨｨ ｨｨ0006ｨｬ0208ｨｪ04ｨｦ ｨ ｨｪｨｰ0602ｨｨｨ ｨｪｨｨ01ｨｨｨｪ060904ｨｦ ｨｺ06ｨｬ070502ｨｺ09 // ｨｨ04ｨｨ ｨｨｨｨ ｨｨ 07ｨ ｨｰ ｨｨｨｨ ｨ ｨｪｨｨ ｨC ｨｨｨｪ , 08ｨｮ03ｨｪ ｨ ｨｨ0708ｨｨｨｬ ｨC 07ｨｨｨｴ0209ｨ ｨ ｨ 09ｨｺｨ ｨ ｨｪｨｨ07 ｨ 05ｨｺ ｨｹｨｪ0401 ｨｪｨ 07ｨｨｨｰｨｺ ｨｨ05ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨｦ09ｨｰ09ｨ ｨｬｨｨ // ｨｰｨｪ ｨC87 6. 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