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1 日本免疫毒性学会 :The Japanese Society of Immunotoxicology Vol. 17 No. 2( 通巻 34 号 )2012 aa aa 東京慈恵会医科大学 東海大学医学部 ( 独 ) 科学技術振興機構 独立行政法人国立環境研究所環境健康研究センター 川崎医科大学衛生学 Meiji Seika ファルマ株式会社 大阪大学大学院薬学研究科毒性学分野博士後期課程 1 年 筑波大学大学院生命環境科学研究科持続環境学専攻 2 年次 連携大学院国立環境研究所環境健康研究センター 分子毒性機構研究室 アサマ化成株式会社 大阪大学免疫学フロンティア研究センターワクチン学研究室 独立行政法人国立環境研究所 Tin Tin Win Shwe 第一三共株式会社安全性研究所 大阪大学大学院薬学研究科毒性学分野 English pages 柳澤裕之 ( 東京慈恵会医科大学環境保健医学講座 ) JSIT takanawa/index.html JR Notch/NotchL 28 PC F A X

2 Henk van Loveren Maastrick University, National Institute of Public Health and the Environment, The Netherlands 1 Overview and Application of the WHO/IPCS Harmonized Guidance for Immunotoxicity Risk Assessment for Chemicals AIM Apoptosis Inhibitor of Macrophage.. In vitro immunotoxicology Emanuela Corsini Laboratory of Toxicology, Dipartimento di Scienze Farmacologiche e Biomolecolari, Faculty of Pharmacy, Universita degli Studi di Milan, ItalyCurrent Trend on In Vitro Immunotoxicology in EU in vitro h-clat Ai-Young Lee Department of Dermatology, Dongguk University Ilsan Hospital, South Korea Irradiation of light emitting diode at 850 nm inhibits T cell-induced cytokine expression Evaluation of anti-drug antibodies during non-clinical safety studies Gray Bembridge (Huntingdon Life Sciences Ltd.) 2

3 Vol. 17 No. 2 (2012) 2 Lawrence D Jacob Charles River Laboratories services 2 Validation and use of several assays to monitor pharmacodynamic markers intended for human use, in the cynomolgus monkey Meiji Seika Human cell line activation Test h-clat senescence p130 6 藤巻秀和学術 編集委員会 : Dr. Jack H. Dean University of Arizona Professor Jacques Descotes Lyon Poison Center 奨励賞 小池英子 ( 独立行政法人国立環境研究所環境健康研究センター ) 24 O 3 NO 2 PM2.5/DEP PM DEP 3

4 DINP NC/Nga DINP TSLPTSLP Th2 DINP BMDC in vitrodinp BMDC Th2 TARC MDC CCR7 CXCR4 MHC class II CD86 T IL-4 DINP IL-4 DINP TTh2 西村泰光 ( 川崎医科大学衛生学 ) Senescence Accelerated Mice, SAM 1970 SAM SAM ? AM TGF- Bcl-2/Bcl-x L AM

5 Vol. 17 No. 2 (2012) NK NK NKp46 NK PBMC NK 年会賞 Human cell line activation Test h-clat 打田光宏 1 土屋敏行 1 宇梶真帆 2 斎藤嘉朗 2 黒瀬光一 2 ( 1 : Meiji Seika ファルマ株式会社 2 : 国立衛研 医薬安全科学部 ) active systemic anaphylaxis passive cutaneous anaphylaxis in vitro THP-1 human Cell Line Activation Test h-clat h-clat 18 1 h-clat 18 CV75 75% 11 ampicillin sodium D-penicillamine ticlopidine hydrochloride cephalothin sodium diclofenac sodium levofloxacin hydrochloride gefitinib albendazole amiodarone hydrochloride carbamazepine pravastatin sodium 7 phenitoin hydrocortisone penicillin G potassium nevirapine acetyl salicylic acid allopurinol amoxicillin CV75 hclat 19 Negative compound? DMSO 5

6 ??? CV75? 1, Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-clat). I. Optimization of the h-clat protocol. Ashikaga T, Yoshida Y, Hirota M, Yoneyama K, Itagaki H, Sakaguchi H, Miyazawa M, Ito Y, Suzuki H, Toyoda H. Toxicol In Vitro Aug;20( 5 ): 学生若手優秀賞 平井敏郎 ( 大阪大学大学院薬学研究科毒性学分野博士後期課程 1 年 ) nm Hirai T et al. Part. Fibre Toxicol IgG/IgE 6

7 Vol. 17 No. 2 (2012) senescence p 岡村和幸 ( 筑波大学大学院生命環境科学研究科持続環境学専攻 2 年次 連携大学院国立環境研究所環境健康研究センター 分子毒性機構研究室 ) senescence p BA20 A20 10 M 8 14 senescence senescence senescence senescence H 2 O 2 A20 H 2 O M 5 H 2 O 2 senescence G0/G1 arrest H 2 O 2 G2/M arrest H 2 O 2 24 G0/G1 arrest p130 p130 H 2 O 2 p130 p130 G0/G1 arrest sirna p130 G0/G1 arrest A20 senescence G0/G1 arrest p 投 稿 塩野谷博 ( アサマ化成株式会社研究顧問 ) ,3,

8 in vitro 3,5-2 3, I - I - 1 /2I 2 I 2 > > X XX 6 6 5,6 in vitro ,5- Nilsson R X in vivo. 3 2 ~-4 IgE 3,5 RASTIgE IgG ECL IgG T4 2 T4 IgERAST

9 Vol. 17 No. 2 (2012) PCA I - I - I ,11 Mikkonen R % ~ 7 46% r=0.613 p< Munechika H / % 7 ~ 9 193/ % 2 p<0.01 Oxygen burst 12,13. IgE IgE IgE , Shionoya H et al. Studies on experimental iodine allergy: 1. Antigen recognition of guinea pig antiiodine antibody. J Toxicol Sci 29: , Shionoya H, et al.: Studies on experimental iodine 9

10 allergy: 2. Iodinated protein antigens and their formation from inorganic and organic iodinecontaining chemicals. J Toxicol Sci 29, , Sugihara Y, et al.: Studies on experimental iodine allergy: 3. Low molecular weight elicitogenic antigens of iodine allergy. J Toxicol Sci 29: , Wolf GL et al,: A prospective trial of ionic vs nonionic contrast agents in routine clinical practice: Comparison of adverse effects. Am J Roentgenol 152, , Katayama H, et al.: Adverse reactions to ionic and nonionic contrast media. A report from Japanese Committee on the Safety of Contrast Media. Radiology, 175: , Nilsson R et al.: Formation of potential antigens from radiographic contrast media. Acta Radiologica 28: , Girard JP, Gamba L,: Radiologic contrast media. In allergic reactions to drugs de Weck AL and Bundgaard H. eds. Handb Exp Pharm, 63: , Mikkonen R, et al.: Seasonal variation in the occurrence of late adverse skin reaction to iodinebased contrast media. Acta Radiol, 41: , Munechika H, et al.: A prospective survey of delayed adverse reactions to iohexol in urography and computed tomography. Eur Radiol, 13: , Emelyanov A, et al.: Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients. Chest, 120: , Vargas L.: A study of granulocyte respiratory burst in patients with allergic bronchial asthma. Inflammation, 22:45-54, Sato K et al.: Occupational allergy in medical doctors. J Occup Health 46: 新評議員より Dirty Little Secret 黒田悦史 ( 大阪大学免疫学フロンティア研究センターワクチン学研究室 ) 2008 Nature Science 80 Immunologist, s Dirty Little Secret

11 Vol. 17 No. 2 (2012) Dirty Little Secret Tin Tin Win Shwe ( 独立行政法人国立環境研究所 ) 河井良太 ( 第一三共株式会社安全性研究所 ) RT-PCR VOC in vivo, in vitro SOA SOA IH Brown Norway Rat 20 DEP 9 T TDAR TDAR 11

12 吉岡靖雄 ( 大阪大学大学院薬学研究科毒性学分野 ) nm 10 nm Nano-Safety Science Nano-Safety Design Sustainable Nanotechnology 世界の免疫毒性研究者へのインタビュー第 3 回 Real Voices of International Immunotoxicologists 3 Real Voices of International Immunotoxicologists 19 Henk Van Loveren Emanuela Corsini Ai-Young Lee EUROTOX JSIT English 12

13 Vol. 17 No. 2 (2012) ImmunoTox Letter 2 20 WHO S.H 発行日 : 平成 24 年 12 月 13

20●12頁●6-14▲放射線科▲.ppt

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