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1 1990Dr. Sackett EBMEvidence-Based Medicine EBMEBM DI EBMDI DI 2 Vol. 22 No

2 Evidence-Based Drug InformationEBDI EBDI IF IF EBDI EBDI EBDI EBDI Vol. 22 No

3 Y2K Celera GenomicsCelera Celera Incyte Pharmaceuticals National Institute of Health Department of Energy Human Genome Project Celera Whitehead Institute for Biomedical Research Genome Sequencing Center at the Washington UniversityBaylor College of MedicineJoint Genome Institute Sanger Centre Vol. 22 No

4 Celera Human Genome Sciences6700 SNP Consortium, Ltd Expressed Sequence TagsESTs Single Nucleotide PolymorphismsSNPs SNPs The SNP Consortium, LtdTSC Wellcome Trust TSC Astra ZenecaBayerBristol-Myers Squibb Hoffmann-La RocheGlaxo-WellcomeHoechst Marion RousselMotorolaNorvatisPfizer SearleSmithKline Beecham Whitehead Institute for Biochemical ResearchWashington University s Genome Sequence CenterWellcome Trust s Sanger CentreStanford Human Genome CenterCold Spring Harbor Laboratory 1123SNP 2566SNPs TSC SNPs15 URL Vol. 22 No

5 6 Vol. 22 No ftp://ftp.sanger.ac.uk/pub/human/sequences ftp://genome.wustl.edu/pub/gsc Sanger Centre SNPs [(3)] 21 [(4)] 2001 cdna SNPs cdna

6 7 Vol. 22 No hierachy a RNA Rational Drug Design Combinatorial Chemistry High-Throughput Screening Pharmacogenomics SNPs DNA DNA SNPs

7 genotype P450CYPCYP2D CYP2D6 CYP2D6 tacrinehcl apolipoproteine E3 25E4 E4 HMG-CoA pravastatin sodium cholesterol ester transport proteinb2 B1 SNPs 21 tailor-made or personalized medicine 8 Vol. 22 No

8 9 Vol. 22 No SNPs b SNPs Polymerase Chain ReactionPCRDNA DNA CVD35 CVD35 E PCR

9 10 Vol. 22 No

10 13 Vol. 22 No

11 Q & A Vol. 22 No

12 15 Vol. 22 No Heinrich Biirger

13 16 Vol. 22 No

14 17 Vol. 22 No

15 18 Vol. 22 No

16 19 Vol. 22 No history/history3/history3.html.

17 Vol. 22 No

18 Vol. 22 No

19 23 Vol. 22 No plastic bronchitis

20 (2000),, plastic bronchitis (1994) 24 Vol. 22 No

21 Vol. 22 No

22 ;; ;;; yyy ;; ;; ;; 26 Vol. 22 No

23 27 Vol. 22 No

24 Vol. 22 No

25 29 Vol. 22 No USP-DI 300 TIP 80 abc de fg

26 H.S Vol. 22 No

27 31 Vol. 22 No a b b1 b2 b3 b4

28 32 Vol. 22 No H.S

29 cm81cm Vol. 22 No

30 34 Vol. 22 No lex salica

31 ha Linum linon usitatissimum usitatas Flax Common flax, flax, Dreschlein, Flachs, Klenglein lin cultivé m cm cm perennial flax lin vivace cm 1.5 cm cm Stellera 5060cm Vol. 22 No

32 cm 3.5mm mm linoleic acid linolenic acidoleic acid stearic acidpalmitic acid glogulin pentosan linamarin 4.5g pentosan g 36 Vol. 22 No

33 lynoxyn Linen Vol. 22 No

34 39 Vol. 22 No Vol.22 No.5 GHQ

35 Vol. 22 No

36 Vol. 22 No

37 t1/2 mg Vol. 22 No

38 tmax t1/ Vol. 22 No

39 DI REPORT 10 HIV DI 1981AIDS AIDS LAVHTLV-ARV 1986 HIV AIDS HIVHIV2 HIVHIV1 HIV2HIV1 HIV 120nm HIV HIV PAEIAHIV WB HIV HIV HIVHIV window periodsilent AIDS HIV HIVp24HIV gag PCRPCR PAparticle agglutination HIV HIV HIV EIAenzyme immunoassay ELISAEnzyme-linked immunosorbent assay EIA HIV Vol. 22 No

40 DI REPORT HIV HIV CLEIAchemiluminescent enzyme immunoassay EIA WBwestern blot immunoblotting method HIV SDSPAGE HIV1 Immunochromatography Assay HIV HIVHIV HIV HIV HIVHIV HIV PCRpolymerase chain reaction HIVDNA HIVCD4 HIVRNA DNADNA CD4DNA RNA CD4PCR DNA chain reaction HIVDNA RTPCRreverse transcription polymerase chain reaction HIVRNA HIVRNA HIVRNA HIV Vol.53No Vol.51No ABC AIDSATL HIV 46 Vol. 22 No

41 DI REPORT HIV12 PA HIV1 HIV HIV1 HIV ,000 H118 HIV12 PA PA HIV1 HIV , ,000 H72 HIV12 EIA HIV1 HIV ,000 H101 HIV1HIV2 EIA HIV1 HIV2 AxSYM 28 1 HIV HIV ,000 [] 4 230ml 45,000 H91 HIV1HIV2EIA PLUS EIA HIV1 HIV HIVHIV HIV OPDOPD ,000 AIDSAIDS H87 AntiHIV12 EIA HIV1 HIV POD ,400 HIV10 H86 HIV12 CLEIA HIV1 HIV HIV ,000 AMPPD 100ml6 150, ml6 30, ml4 64,000 H93 Vol. 22 No

42 DI REPORT HIV HIV 12 WB HIV WB HIV WB HIV1HIV WB HIV 28 4 HIV 1HIV HIV HIV12HIV HIV 63 72, , , , ,500 HIV1 H37 HIV2 H36 WB HIV12 HIV 1HIV2 H36 WBEIA AIDS HIV HIV H2 H Vol. 22 No

43 DI REPORT HIVEIA EIA HIV HIV p HIVIgG HIV OPDOPD 1N ,000 H411 HIV1 PCR HIV1DNA 28 HIV 6 PN HIV DNA 10 HIV ,000 HIV ,000 HIV1DNA H64 HIV1 RT PCR HIV1 RNA 28 6 HIV1 QS HRP A B ,000 HIV HIV H93 HIV EIA HIV1 OHIV2 HIVp HIV4HIV4 HIV4C1 HIV4C2HIV4 S ,000 HIV1HIV2 HIVp24 HIV H Vol. 22 No

44 ddddddddddddddddddddddddddddddddddddddddddddd ddddddddddddddddddddddddddddddddddddddddddddd TB Vol. 22 No

45 B 97 BT 52 Vol. 22 No

46 97T Vol. 22 No

47 T T 54 Vol. 22 No

48 Vol. 22 No

49 56 Vol. 22 No

50 Vol. 22 No

51 immunolgobulin YFcIgGIgAIgMIgDIgE IgE T IgE IgG IgG MHC MHC T 58 Vol. 22 No

52 59 Vol. 22 No MHC T T Y!!! 12TTTh1 12 BIgG T TTTh B

53 TNF CDcluster of differentiation CD4TCD8T CD CD86TCD28 CD160 97T TMHC TMHCT TT B BY IIMHC 60 Vol. 22 No

54 BB MHCTT AIDS, CD, Ig, MHC, TNF AIDS acquired immunodeficiency syndrome CD cluster of differentiation Ig immunogloblin MHC major histocompatibility complex TNF tumor necrosis factor Vol.21 No.8 Vol.22 No.2 Vol.21 No.9 Vol.22 No.3 Vol.21 No.10 TDNA Vol.21 No.11 Vol.22 No.4 10Vol.22 No.5 Vol.21 No.12 11Vol.22 No.6 Vol.22 No.1 12Vol.22 No.7 Vol. 22 No

55 62 Vol. 22 No

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58 PI , ,938 vu , ,555,333 1,394,932 24,160,401 Vol. 22 No

59 /1018 / A 21 Topic http// 66 Vol. 22 No

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