資料1(目消し版).ppt

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1 1

2 Dr. Grandjean 2

3

4 4

5 CH 3 Hg + Hg 0 fi Hg ++ fich 3 + MeHg MeHg 5

6 Methylmercury-2 6

7 :, A. Yasutake 7

8 - A. Yasutake 8

9 :,. A. Yasutake 9

10 A. Yasutake 10

11 (%) : : : : : MeHg : 2 : 1 : 0.1 : 0.05 : 0.05 MeHg(%) 98% 98% 95% 30% 1% 30% 11

12 12

13 ppm ppm 13

14 ( ) Mean level Female: 1.6 ppm (n = 2265) Male: 2.5 ppm (n = 3668) Female Male EPA(75%) JECFA(25%) (0.7%) (ppm) Yasutake et al. (2004) 14

15 15 15

16 5ppm 5ppm Toxicol Environ Chem (in press) Brain Res 2002; 949:

17 (5ppm Hg) 8 ( ) ( ) 30 (5ppm Hg) 17

18 18

19 19

20 20

21 21

22 3 Environ Res 2002; 90: Environ Sci Tech 2004; 38: Environ Health Prev Med 2004; 9:

23 (constant) 10 23

24 (53 ) (16 ) 24

25 P<

26 (ng/g) (ng/g) y = x r =

27 Mean=1.6 27

28 RBC 13.0 ng/g RBC 8.2ng/g 28

29 P<

30 RBC 13.0 ng/g ng/g RBC 6.9 ng/g 30

31 7 3 31

32 32

33 A= (a/b)bh/ln 2(1 exp ( ln 2 /BHt)) a= ;b: ; A: (t); H 0 = ; BH= 70 ( ); t=. 33

34 34

35 35

36 36

37 37

38 38

39 Grandjean: Human milk as a source of methylmercury exposure in infants. Env.. Health Perspect 102 (1994) 39

40 40

41 41

42 42

43 Environ Health Prev Med 2004; 9: Environ Sci Tech 2004; 38:

44 (LN, 18:2-n6) (LnN, 18:3-n3) (DHA, 22:6-n3) (AA, 20:4- n6)aa DHA 44

45 / Saturated & Mono-unsaturated C20:3n-6 * C20:4n-6 * C18:2n-6 * C18:3n-3 * C20:5n-3 22:6-3 * n-3 n-6 45

46 ** y = 0.135x r =

47 (ug/ml) ** y = 0.135x r = (ng/g) 47

48 , DHA, EPA Hg Hg 48

49 () 1-40 ( ) 0.09 ppm 0.04 ppm 49

50 50

51 1. Amin-Zaki L, Elhassani S, Majeed MA, Clarkson TW, Doherty RA, Greenwood M. Intra-uterine methylmercury poisoning in Iraq. Pediatrics Nov;54(5): Grandjean P, Jorgensen PJ, Weihe P. Human Milk as a Source of Methylmercury Exposure in Infants. Environ Health Perspect Jan;102(1): Sakamoto M, Kakita A, Wakabayashi K, et al. Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: e a study with consecutive and moderate dose exposure throughout gestation and lactation periods. Brain Res 2002; 949: Sakamoto M, Kubota M, Matsumoto S, et al. Declining risk of methylmercury exposure to infants during lactation. Environ Res 2002; 90: Sakamoto M, Kubota M. Plasma fatty acid profiles in 38 pairs of maternal and umbilical cord blood samples. Environ Health Prev Med 2004; 9: Sakamoto M, Kubota M, Liu XJ, Murata K, Nakai K, Satoh H. Maternal and fetal mercury and n-3 n 3 polyunsaturated fatty acids as a rik and benefit of fish consumption to fetus. Environ Sci Tech 2004; 38: Pan H.S, Sakamoto M, Oliveira R.B. et al. Changes in methylmercury ry accumulation in the brain of rat offspring throughout gestation and during suckling. Toxicol Environ Chem 2004; 86:

52 52

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