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1 Study on Clinical Factors Affecting the Fungal Culture Test - Relevance of Dry Mouth - Yoshiko YAMAMURA, Yukihiro MOMOTA, Hideyuki TAKANO, Koichi KANI, Katsumi MOTEGI, Fumihiro MATSUMOTO, Masayuki AZUMA In order to analyze the clinical factors affecting the fungal culture test, we examined the oral mucosae of individuals with various complaints: pain, xerostomia etc. The subjects, age ranged from to years (mean age:.. ). Based on the fungal culture, patients were found Candida-positive, and the remaining patients were Candida-negative. The mean ages of the Candida-positive and -negative groups, respectively, were.. and.. years old, with the Candida-positive group being significantly older than Candida-negative group. The Candida-positive group showed a smaller amount of salivary secretion (.. ml/ min) than the Candida-negative group (.. ml/ min); this difference was also statistically significant. Patients with Candida infection suffered from different diseases and conditions, including hypertension, gastrointestinal disease, and xerostomia. The above findings suggest that one of the factors in the fungal culture test is dry mouth. Specifically, old age, dry mouth, chronic disease or medication leading to dry mouth were the clinical factors affecting the fungal culture test. However, neither the Candida species detected in the fungal culture nor the clinical appearance of the oral mucosa influenced these clinical features., Department of Oral Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School of Dentistry

2 GS BD B Chi-square test Mann-Whitney U test. Candida albicans Candida glabrata Candida tropicalis C. albicans C. glabrata C. tropicalis Chi-square Test: p >. C. albicans. C. glabrata C. tropicalis Chi-square Test: p >.. Chi-square Test: p >..... Mann-Whitney U test: p <. C. albicans.. C. glabrata.. C. tropicalis.. Mann-Whitney U test: p > Mann-Whitney U test: p >. Chi-square Test: p <. C. albicans. C. glabrata. C. tropicalis. Chi-square Test: p >.... Chi-square Test: p >... ml

3 .. ml Mann- Whitney U test: p. C. albicans.. ml C. glabrata.. ml C. tropicalis.. ml Mann-Whitney U test: p >.

4 ** *.. ml.. ml.. ml Mann-Whitney U test: p > (. ).... Chi-square Test: p. C. albicans C. glabrata C. tropicalis C. albicans. C. glabrata. C. tropicalis. Chi-square Test: p >.... Chi-square Test: p >... Chi-square Test: p >. C. albicans C. glabrata C. tropicalis C. albicans. C. glabrata. C. tropicalis. Chi-square Test: p >.... Chi-square Test: p >... C. albicans.

5 . C. glabrata.. C. tropicalis. Chi-square Test: p > Chi-square Test: p >. PAS, β D,

6 - - - H Kurita, T Kamata, Chen Zhao et al: Usefulness of a commercial enzyme-linked immunosorbent assay kit for candida mannan antigen for detecting candida in oral rinse solutions. Oral Surg Oral Med Oral Pathol Oral Endod, - ( ) Jpn. J. Med. Mycol

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