2}xx4,uA 20xxaFuE

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1

2 2}xx4,uA 20xxaFuE

3

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8 7 ty I z7-7 lmg. 7 t/ z7-7 4mg, 7 ty I z7-/ 9mg

9 7 ay / =)V2 s.r&ffi 5cm2

10 mg/e 0.6 mg,/e 1.2 mg/e ^e/a mg/trt.2 'n mg/e 1.8

11

12

13 C.r* \ps/ml) AUCo.zl (pg. hr/ml) AUCzrcz+o (pg.hrlml) Zmg6=7) 4mg(n=5) -f- 2mg(n:6) -*- 4mg(n=8) (4mett26hrtjl.K.n=7)

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15 HO COzH.Hozc.-X-.cozH

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23 t>*tfry*

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25 (iluei* : bioassay) (mean:ts. D. )

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30 Cma* (nelmi-) LI/z. lj (Hl mean asd Cma (ns/ml) mean I sd *'.- - l20mg(1= 22-39; mean I SD

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35 7./Va*)L 2tvz7tSY

36 I lv =r)*)v / p =F'/'*tv

37 lj.t - I 1.74E3) g.g7e1)

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44 tuaxx (h)

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50 7ZTVt,vZ'kririur-=)

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57 ,/ ta/jv,t) t.,^ _TQ :

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60 ls4!i

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64 60 mg QD 20 mg QD 60 mg QD

65 null resdonder partial resonder

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68 7rx77*rrTall looms

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71 200mg(6 FtJ)

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73 null responder

74 --++.O.<.-a>-

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76 D-:77;I-)L 45ms

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85 Tmax (hr) AUCo soa (pg'hr/ml,)

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96 4)Jnzz> -r ti-lur -t\7 )vi

Microsoft Word - 表紙資料2-4

Microsoft Word - 表紙資料2-4 (1) / 130 g 25 g 520% 170 g 30 g 560% 70 mg 600 mg 11.6% 0 10.5 mg 0% (1) (2) / 50100 g 25 g 200400% 50100 g 30 g 167333% 5001000 mg 600 mg 83167% 1020 mg 10.5 mg 95190% (2) / (1) 45.6 g 30 g 152% (2)

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