2}xx4,uA 20xxaFuE
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- みさえ うるしはた
- 7 years ago
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1
2 2}xx4,uA 20xxaFuE
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8 7 ty I z7-7 lmg. 7 t/ z7-7 4mg, 7 ty I z7-/ 9mg
9 7 ay / =)V2 s.r&ffi 5cm2
10 mg/e 0.6 mg,/e 1.2 mg/e ^e/a mg/trt.2 'n mg/e 1.8
11
12
13 C.r* \ps/ml) AUCo.zl (pg. hr/ml) AUCzrcz+o (pg.hrlml) Zmg6=7) 4mg(n=5) -f- 2mg(n:6) -*- 4mg(n=8) (4mett26hrtjl.K.n=7)
14
15 HO COzH.Hozc.-X-.cozH
16
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23 t>*tfry*
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25 (iluei* : bioassay) (mean:ts. D. )
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30 Cma* (nelmi-) LI/z. lj (Hl mean asd Cma (ns/ml) mean I sd *'.- - l20mg(1= 22-39; mean I SD
31
32
33
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35 7./Va*)L 2tvz7tSY
36 I lv =r)*)v / p =F'/'*tv
37 lj.t - I 1.74E3) g.g7e1)
38
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44 tuaxx (h)
45
46
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50 7ZTVt,vZ'kririur-=)
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57 ,/ ta/jv,t) t.,^ _TQ :
58
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60 ls4!i
61
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64 60 mg QD 20 mg QD 60 mg QD
65 null resdonder partial resonder
66
67
68 7rx77*rrTall looms
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71 200mg(6 FtJ)
72
73 null responder
74 --++.O.<.-a>-
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76 D-:77;I-)L 45ms
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85 Tmax (hr) AUCo soa (pg'hr/ml,)
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96 4)Jnzz> -r ti-lur -t\7 )vi
12-7 12-7 12-7 12-7 12-8 12-10 12-10 12-10 12-11 12-12 12-12 12-14 12-15 12-17 12-18 10 12-19 12-20 12-20 12-21 12-22 12-22 12-23 12-25 12-26 12-26 12-29 12-30 12-30 12-31 12-33 12-34 12-3 12-35 12-36
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(1) / 130 g 25 g 520% 170 g 30 g 560% 70 mg 600 mg 11.6% 0 10.5 mg 0% (1) (2) / 50100 g 25 g 200400% 50100 g 30 g 167333% 5001000 mg 600 mg 83167% 1020 mg 10.5 mg 95190% (2) / (1) 45.6 g 30 g 152% (2)
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More information180 30 30 180 180 181 (3)(4) (3)(4)(2) 60 180 (1) (2) 20 (3)
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