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- えの ふじがわ
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1 ﾁ ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ02 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ ｨｬｨｨ080609ｨ ｨｪｨｨ ｨｮ ｨｦ ｨｮ05ｨｨｨｰｨｺｨｨ ｨｨ ｨｺ0608ｨｰｨｨ0209ｨ ｨ ｨｪｨ ｨｨ ｨｪ ﾂ ｨｪｨｨ ｨｨｨｦ 09ｨｺ06ｨｦ ｨ ｨｺｨ 0102 ｨｬｨｨｨｨ ｨｬ02 01ｨｨ 02ｨｨｨｪ 09ｨｺｨｨ01 ｨｪｨ ｨｮｨｺ ｨｨ ｨｺ ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨｨｨｦ ｨｪｨ ｨｮ ﾂ ｨｪ04ｨｦ 0202ｨｪｨｰ , ｨｨ07, , ｨｺ 09ｨ, ｨｮ ｨｺ ﾂｨｹ02, E-ma il: mgli 08ｨｪｨ 05ｨｨ04ｨｨ08ｨｮ06ｨｰ0907 ｨｪ02ｨｺ06ｨｰ ｨｨ ｨｪ0609ｨｪ , ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｴｨｨ ｨｬｨｨ080609ｨ ｨｪｨｨｨｨ ｨｺ0608ｨｰｨｨ0209ｨ ｨ ｨｪｨ 09ｨｪｨｮｨｰ0802ｨｪｨｪ ｨｮ01ｨ ｨｮ ﾂ ｨｺｨ ｨｨ ｨｬ0403ｨｨ, ｨｰｨ ｨｺｨｨ02, ｨｺｨ ｨｺ ｨｨ000208ｨ 02ｨｨ07, ｨｬ0203ｨｰｨｺｨ ｨｪ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ07, ｨｺ06ｨｪ ｨｪｨｰｨｪ0602 ｨｮ0105ｨｨｨｪ02ｨｪｨｨ02, ｨｺ0609ｨｰｨｪｨ 07 ｨｺ0502ｨｰ06 ﾂｨｪｨ ｨｪ0609ｨｰｨｹ, 0102ｨｰ0208ｨｬｨｨｨｪｨ 02ｨｨ07 ｨｨ 01ｨｨ ｨｪ02ｨｨ080609ｨｺｨ ｨｰｨｨ ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ06ｨｰ ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｨ 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ06ｨｰ ｨｬ ｨｪ0204ｨ 09ｨｪｨｮｨｰ0802ｨｪｨｪ ｨｮ01ｨ ﾂ ｨ : 09ｨｪｨｮｨｰ0802ｨｪｨｪ0202 ｨｮ0106, ｨｺ0608ｨｰｨｨ ｨ ｨｪ, ｨｮ05ｨｨｨｰｨｺｨ, ｨｬ ｨｪ0204, 0002ｨｪ02ｨｰｨｨｨｺｨ 08ｨ 0409ｨｨｨｰｨｨ ｨｪｨｨ02 04ｨ ｨｪ0202 [1] ｨｬ04 08ｨ 09 09ｨｬ06ｨｰ ｨｨ, ｨｺｨ ｨｺ ｨｨ ｨｮ ｨｦ 0705ｨ ｨｺ ｨｰ ｨ ﾂｨ ｨｰ ｨｺｨｨ ｨ ｨｪｨ 08ｨ 09 ｨｪ ｨｨ07 ｨｨ 0905ｨｮ 01ｨ ｨ ｨｨ ｨ ﾂｨ ｨｰ ｨｺｨ 0905ｨｮ ｨｦ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｪｨ ﾂｨｨ ｨｪｨ 02ｨｰ 0907 ｨｬ ｨｪ0204 ｨｪｨ ｨ ｨ ｨ 04 ｨｪ06 06ｨ 08ｨ 04 ｨｪ ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨｨ : ｨｨ ｨ 02ｨｨｨｨ ｨｺ0502 ｨｰ06ｨｺ ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ ｨｪｨ ; ｨｬ0203 ｨｰ ｨｺｨ - ｨｪ ｨ ｨｨ ｨｬ ｨｦ 09ｨｰ 09ｨｨｨｦ; ｨｺ06ｨｪ ｨｪ ｨｰ ｨｪ ｨｮ01 05ｨｨ ｨｪ02 ｨｪｨｨ07; ｨｺ0609ｨｰｨｪ06ｨｦ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｪ0609ｨｰｨｨ; 0102ｨｰ0208ｨｬｨｨｨｪｨ 02ｨｨｨｨ ｨｨ 01ｨｨ ｨｪ 02ｨｨ ｨｺｨｨ 08ｨ 04 ｨｪ0401 ｨｰｨｨ ｨｺ0502 ｨｰ06ｨｺ ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ - ｨｪｨ. 06ｨｰｨｨ ｨｮｨｴ0209ｨｰ ｨｰ ｨｪ06ｨｬ 0904ｨ ｨｨｨｬ ｨｦ09ｨｰ09ｨｨｨｨ ｨｪ ｨｮ ｨｦ ｨｮ05ｨｨｨｰ ｨｺｨｨ 01ｨ 08ｨｨ 09ｨｮｨｪ ｨｺ02 ｨｺ0608 ｨｰｨｨ ｨ ｨｪ ｨｰｨ ｨｪ ｨｦ ｨｪ06 09ｨｰｨｨ. 08ｨ ｨｺ ｨｮ ｨｴ02 09ｨｰ ｨｰ ｨｬ ｨｪ0204? 0607ｨｨ ｨｰ02 05ｨｨ ｨ 05ｨｹ ｨｪ04ｨｦ 04ｨ ﾂｨ ｨｰ06ｨｺ 0905ｨｮ ｨｺｨ ｨｪｨ 05ｨ 09ｨｪｨ ﾂｨ 05ｨ ｨｰｨ ｨｪ ｨｺ ｨｰ ｨｺ06ｨｦ, ｨｦ, 04ｨ ｨｺｨ ｨｪ ﾂｨｨ 09ｨ 06 ｨｴ02ｨｦ ｨｰ08ｨｮｨ - ｨｺ06ｨｦ, 06ｨｺ08ｨｮ 0302ｨｪ ｨｪ06ｨｦ ｨｬ ｨｪ 01ｨｨ ｨｬ06ｨｦ ｨｮ 05ｨｹ ｨｰｨ ｨｰ02 ｨｨ ｨｰ06 07ｨｪ - ｨｪ ｨ ｨｨ ｨｬ ｨｦ 09ｨｰ 09ｨｨ07 ｨｨ 0906 ﾂ02 ｨｰｨ ｨｪ ｨｪ ｨｰｨ ｨｨ 06ｨ 08ｨ 04ｨｮ 02ｨｰ ｨｮ ｨ 07 ｨｮ05ｨｨｨｰ ｨｺｨ ｪ 09ｨｪ0203 ｨｪｨｨｨｦ ｨｴ ｨｦ, ｨ 04ｨ ｨｰ02ｨｬ ｨｺ06 09ｨｰ ｨｪ04ｨｦ ｨｺｨ 08 ｨｺｨ 09, 09 ｨｺ06 ｨｰ ｨｬ 0706 ｨｬ02 ｨｴｨ 02ｨｰ ｨｪ ﾂｨ ｨｰｨ 07 ｨｮ05ｨｨｨｰ ｨｺｨ, ｨｰ ｨｮ ｨｦ ｨｺｨ ｨｪｨ 05, ｨ ｨｴｨｨｨｦ ｨｺ0608 ｨｰｨｨ ｨ ｨｪ ｨｰ 04ｨ ﾂｨ ｨｰ ｨｺｨ 0905ｨｮ ｨｦ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｨ ｨｨｨｰ ｨｪ ｨｰ ｨｬ02 01ｨｨ ｨ 05ｨｹ ｨｪ06ｨｬ ｨｪｨ 0708ｨ ｨｪｨｨｨｨ, ｨｬｨｨ 08ｨｮ07 L-06ｨ 08ｨ 04 ｨｪ04ｨｦ ｨ ｨｪ ( ｨｨ ｨｪｨ 09ｨｨｨｰ ｨｺｨ ) ｨｪｨ 12-ｨｦ 0102ｨｪｨｹ 05ｨｬ ｨ 08ｨｨ ｨｪ02 04ｨ ｨｬ04-03ｨｨ. 05ｨ ｨｰ02ｨｬ ｨｺｨ ｨｪｨ 05 ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨ 02ｨｰ ｨｮ ｨｨ ﾂｨｨ 09ｨ ｨｰｨｹ 0907 ｨｨ 04ｨ - ｨｺ08ｨｮ ﾂｨｨ 09ｨ 02ｨｰ 0907, ｨｰｨ ｨｺ ﾂｨｰ06 ｨｮ ｨｬ ｨｦ 09ｨｰ08ｨｮｨｺ ｨｰｨｮ 08ｨ ｨｰ06 - ｨｨｨｰ 0706 ﾂ ｨｰｨｨ ｨｨ ｨｮ01 09ｨｨｨｰ ｨｺ ｨｬ ｨ 08ｨｨ 06 ｨｪ0609 ﾂ ｨｺｨ 04ｨ ｨｺ08ｨｮ ﾂｨｨ - 09ｨ ｨｪｨｨ02 ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｪｨ ﾂｨｨ ｨｪｨ 02ｨｰ 0907 ｨｪｨ 9-ｨｦ ｨｪ ｨｨ 04ｨ ｨ 02ｨｰ ｨｰ02 ﾂ02 ｨｪｨｨ02 10-ｨｦ ｨｪ ｨｨ ｨ ｨｬ02ｨｪ ｨｪ06 09ｨｰｨｨ. 02ｨ 08ｨ 04ｨｮ 02ｨｰ ｨ ｨｨｨｪ06ｨｦ 09ｨｨｨｰｨｺｨ ｨｬｨ 08ｨｨ06ｨｪ0609 ﾂ ｨｺｨ ｨｪ ﾂｨ ｨｰ04ｨｦ 05ｨ ｨ ｨｨ08ｨｨｨｪｨｰ 09ｨｪｨｮｨｰ ｨｪ ｨｪ ｨｮ01ｨ 06ｨｺ08ｨｮ 0302ｨｪ ｨｰ ｨｪ ｨｬ ｨｪ 01ｨｨ ｨｬ06ｨｦ, ｨｺ06 ｨｰ06-08ｨ ｨｹ ｨｪ06 08ｨ ｨｪ06 (ｨｪｨ 7 ｪ8-ｨｦ ｨｪ ｨ ｨｬ02ｨｪ ｨｪ06 09ｨｰｨｨ) ｨｪｨ - ﾂｨｨ ｨｪｨ 02ｨｰ ｨ 08ｨ ｨ ｨｰｨｹ ｨｴ. 0507ｨｮ 09 ｨｰ07 9 ｨｪ ｨｹ 08ｨ 04-09ｨｨ ｨｰｨｨ07 ｨｬ ｨｪ 01ｨｨ ｨｬｨ, 06ｨｺ08ｨｮ 03ｨ 06 ｨｴｨ ｨｮ ｨｦ 07ｨｮ ｨｺ, ｨｺ06ｨｪ ｨｪ 09ｨｨ 08ｨｮ 02ｨｰ 0907 ｨｨ 01ｨｨ ｨｪ 02ｨｨ 08ｨｮ 02ｨｰ ｨｴ02 09ｨｮ ｨｮ ｨｮ06 ｨｺｨ 07 09ｨｮ 05ｨｮ (otic cap su le) ｨｰ ｨｺｨｨ ｨｴｨ ｨ 06 00ｨ ｨｰ ｨｨ ｨｺ ｨｪ06ｨｬ, ｨ 0609ｨｪ0609 ｨｪ ｨｴ02 09ｨｰ ｨｨｨｰ ｨ 06 05ｨｹ ｨｺ06 05ｨｨ ﾂ02 09ｨｰ 0906 ｨｬｨｮ - ｨｺ ｨｨ09ｨ 01ｨ 08ｨｨ ｨｮ ｨｴ020906ｨｦ ｨｺｨ 0709ｨｮ0506ｨｦ ｨｨ ｨｪ ﾂｨ ｨｰ04ｨｬ 05ｨ ｨ ｨｨ 08ｨｨｨｪ ｨｰ06ｨｬ, ｨｺ06 ｨｰ ｨｦ ｨｨ04 ｨｺ08ｨｮ ﾂ - ｨｪｨｨ ｨｺ02 ｨｺｨ ｨｪｨ 05ｨ 09ｨｰｨ ｨｪ06 09ｨｨｨｰ 0907 ｨｮ ｨｴ02ｨｪ ｨｪ04ｨｬ 09 ｨｪｨｨ03 ｨｪ02ｨｦ ﾂｨ 09 ｨｰｨｨ (06ｨ 08ｨ 04ｨｮ 02ｨｰ ｨｪ06), ｨｴ ｨｰｨ 02ｨｰ ｨｪｨ ﾂｨｨ ｨｰ02 05ｨｹ ｨｪ ｨｰ08ｨ ｨｪ 09ｨｰ 0906, 04ｨ ｨｪ07 ｨｰ0602 ｨｬ ｨｪ 01ｨｨ ｨｬ06ｨｦ. 05ｨ 09 ﾂ02ｨｰ 0200 ﾂｨ 09 ｨｰｨｨ, 0708ｨｨ ｨ 06 ｨｴ02ｨｦ ｨｺ ｨｺｨ ｨｪｨ 05ｨｮ, 06ｨ 08ｨ 04ｨｮ 02ｨｰ ｨｨ ｨｪｨｨ ｨｰ02 05ｨｹ ｨｪ06ｨｰ ｨｺｨ ｨｪ ｨｪｨ 07 06ｨ ﾂ ｨｺｨ ｨｪ ﾂｨ ｨｰ ｨ ｨ ｨｨ 08ｨｨｨｪ ｨｰｨ. 0209ｨｰｨ 05ｨｹ ｨｪｨ 07 ｨｬ ｨｪ 01ｨｨ - ｨｬｨ, 08ｨ ｨｪｨｪｨ ｨｺ08ｨｮ03ｨｪ0609ｨｰｨｨ ｨｪ ﾂｨ ｨｰ ｨ ｨ ｨｨ - 08ｨｨｨｪ ｨｰｨ, ｨｨ ｨｪｨｨ 0302 ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ, ｨｰ ｨ 02ｨｰ ｨ 08ｨ 04ｨｪ04ｨｦ ｨ 0907ｨ 01ｨ ｨｨ 08ｨ 0403ｨｨ0302ｨｪｨｨ ｨｮ05ｨｹｨｰｨ ｨｰ02 ｨｬ ｨｮ ｨｴ ｨｦ 0905ｨｮ ｨｦ ｨｺｨ 07 09ｨｮ 0506ｨｦ ｨｨ ｨｺｨ ｨｪｨ 0506ｨｬ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｰ ｨ ｨｺｨｮ 06 05ｨｨ, ｨｺ06 ｨｰ ｨｪｨ ﾂｨｨ ｨｪｨ 06ｨｰ 0905ｨｨ 09ｨ ｨｰｨｹ ｨｬ ｨ 08ｨｨ 06 ｨｪ0609 ﾂ ｨｺｨ ｨｪ ｨｹ 08ｨ 04 09ｨｨ ｨｰｨｨ ｨｨ ｨｰ02-05ｨｨｨｦ, ｨｰｨｨ 05ｨ 06 ｨｴｨｨｨｦ 01ｨｪ06 ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ, ｨｮｨｰ0605 ｨｴｨ 02ｨｰ 0907 ｨｪｨ ｨｬ ｨｰ ｨｪｨｨｨｨ 04ｨ 09ｨｨｨｰ ｨｺ0609 ｨｺｨ ｨｪｨ 05ｨ ｨｨ 06ｨ 08ｨ 04ｨｮ 02ｨｰ 04ｨ ｨｺ05ｨ 01 ｨｺｨｮ ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ ｨｪｨ, ｨｺ ｨｺ06 ｨｰ ｨｬｨｮ ｨ 09 ｨｰｨ 06ｨｰ 0102ｨｪ 01 08ｨｨ ｨｰ04 ｨｺ ｨｰ06ｨｺ 0907ｨｨ 08ｨ 05ｨｹ ｨｪ ｨ ｨｪ 00 05ｨｨ07. 08ｨ ｨｪｨ 05 ｨｮ05ｨｨｨｰ ｨｺｨｨ 0708ｨｨ 06ｨ 0802 ｨｰｨ 02ｨｰ ｨｰ0802 ｨｮ ｨｹ ｨｪｨｮ ｨｬｨｮ ｨｪｨｨ ｨｺｨ 06 ｨｴｨｨ ｨｺ08ｨｮ00 ｨｪ ｨ ｨｺｨｮ 06 05ｨｨ 09 ｨｬ ｨｪ 01ｨｨ ｨｬ ｨ 06ｨｰ 0905ｨｨ 09ｨ ｨｰｨｹ 0907, ｨｬｨｨ 08ｨｮ ｨｨ - 05ｨｨｨｬ 00ｨ ｨｰｨｨ ﾂ02 09ｨｺｨｨ ｨｰ08ｨ ｨｪ 09ｨｰ 09ｨ ｨｮ 05ｨｹ ｨｰｨ ｨｰ02, ｨｪ ﾂｨ - ｨｰ04ｨｦ 05ｨ ｨ ｨｨ 08ｨｨｨｪｨｰ 06ｨｺｨ ｨ 02ｨｰ ｨｮ 0302ｨｪ ｨｪ04ｨｬ ｨｨ 05ｨｨｨｬ 00ｨｮ ｨｨ 05ｨｨｨｬ 00ｨ ｨｰｨｨ ﾂ02 09ｨｺ ｨｰ08ｨ ｨｪ 09ｨｰ 09ｨ ｨｺ06 09ｨ 07 09ｨｰ02ｨｪ ｨｺｨ ｨｺｨ - ｨｪｨ 05ｨ ｨｰｨ ｨｪｨ ｨｮ01ｨｨ09ｨｰ06ｨｦ ｨｺ06ｨｦ (stria vascularis) ｨｨ 06ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ 00ｨｨｨ ｨｨｨｰｨ ｨｬｨｨ ｨｪｨｨ02 06ｨ 04 ﾂｨｪ06 ｨｺ05ｨ 0909ｨｨ00ｨｨ02ｨｨ08ｨｮ06ｨｰ0907 ｨｪｨ 5 08ｨ 04ｨｪ0401 ｨｰｨｨ ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ ｨｨ01 08ｨ ｨｪｨｨ07 ｨｨ 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨｦ09ｨｰ09 [90]. 0206ｨｪｨｪｨ 07 ﾂｨ 09ｨｰｨｹ ｨｺｨ ｨｪｨ 05ｨ, ｨ ｨ 04ｨｨ ｨｪｨ ｨ 09 ｨｰｨｨｨｪ ｨｺｨ, ｨｰｨ ｨｪｨ 0902ｨｪ ｨｪ04ｨｬ ｨｬ02ｨｪ ｨｰ06ｨｬ, 04ｨ ﾂｨ ｨｰ ｨｺ06ｨｬ ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ ｨｪｨ, ｨｨ ｨ 06 05ｨｹ - 03ｨｨｨｬ 0507ｨｨ ｨｰ02 05ｨｨ ｨ 05ｨｹ ｨｪ04ｨｬ ｨ ｨｪ02ｨｬ. 0606ｨｪ ｨｺｨ 07 ｨｬ02 01ｨｨ ｨ 05ｨｹ ｨｪｨ 07 09ｨｰ02ｨｪ - ｨｺｨ ｨｺｨ ｨｪｨ 05ｨ 06ｨ 08ｨ 04ｨｮ 02ｨｰ 0802ｨｦ 0909ｨｪ ｨｺｨｮ06 ｨｬ02ｨｬ ｨ 08ｨ ｨｪｨｮ ｨｪｨｨ ｨｺｨ - 06ｨｰ ｨｰ08ｨｨ ｨｰｨｨ, ｨｨ05ｨｨ ｨｺ0608ｨｨ010608ｨ : ｨｦ09ｨｪ ｨｺ06ｨｦ ｨｬ02ｨｬ ｨ 08ｨ ｨｪ04 06ｨ 08ｨ 04ｨｮ 02ｨｰ ｨｪｨｨｨｦ ｨｺ06 08ｨｨ , ｨｨ05ｨｨ ｨｰ ｨｪｨｨ 02ｨ ｨｨ07 (sca la ves ti bu li), ｨｺ06 ｨｰ06 08ｨ 07 04ｨ ｨｺｨ ｨｪ ﾂｨｨ 09ｨ 02ｨｰ ｨ 05ｨｹｨｪ04ｨｬ 06ｨｺｨｪ06ｨｬ; ｨｪｨｨ0302 ｨ ｨ 04ｨｨ050708ｨｪ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ04 ｨｪｨ ｨｨｨｰ ｨｪｨｨ03ｨｪｨｨｨｦ ｨｺ0608ｨｨ010608, ｨｨ05ｨｨ ｨ ｨ 08ｨ ｨ ｨ ｨｪｨｪｨ ｨｰｨｪｨｨ02ｨ 03 (scala tim pa ni), ｨｺ06 ｨｰ06 08ｨ 07 04ｨ ｨｺｨ ｨｪ ﾂｨｨ 09ｨ 02ｨｰ 0907 ｨｺ08ｨｮ ｨｬ 06ｨｺ ｨｪ06ｨｬ; ｨｪ ｨｰｨｹ (sca la me dia) 0906ｨ 09ｨｰ 0902ｨｪ ｨｪ06 ｨｺｨ ｨｪｨ 05 ｨｮ05ｨｨｨｰ ｨｺｨｨ, ｨ ｨｴｨｨｨｦ ｨｺ0608 ｨｰｨｨ ｨ ｨｪ ｨ ｨｺｨ ｨｪｨ 05ｨ ｨ ｨｰ ｨｨ 05ｨｨｨｬ 00ｨｮ, ｨ ｨｺｨ ｨｪｨ 05 ｨｮ05ｨｨｨｰ ｨｺｨｨ ｪ 05ｨｪ ｨｨｨｬ 00ｨｮ. ISSN
2 ﾁ ｨｰ06 08ｨ 07 09ｨｰｨ 01ｨｨ07 08ｨ 04 09ｨｨ ｨｰｨｨ07 (11 ｪ12 ｨｪ ｨｹ ｨ ｨｬ02ｨｪ ｨｪ06-09ｨｰｨｨ ｨｬ ｨ 08ｨｨ 06 ｨｪ0609 ﾂ ｨｺｨ ; ｨｮ 05ｨｬ ｨ 08ｨｨ 06 ｨｪ0609 ｨｬ04-03ｨｨ) 01ｨ 08ｨ ｨｺ ｨｰ02 08ｨｨ 04ｨｮ 02ｨｰ ｨｪｨｨ 02ｨｬ ｨｨ 04ｨｪｨ ｨｺ ｨｨ ｨｪ 02ｨｨ ｨｺｨｨ ｨｺ ｨｨ ｨｨ 09ｨ 06 ｨｴｨｨ01 ｨｺ ｨｰ06ｨｺ. 04ｨ 04 ｨ ｨｮ01 03ｨｨ02 ｨｪ ｨｪ ｨｺ06ｨｪ ﾂｨ ｨｪｨｨ07 ｨｺ0502 ｨｰ06ｨｺ 0907ｨｨ 08ｨ 05ｨｹ ｨｪ ｨ ｨｪ 00 05ｨｨ07 ｨｺ06ｨｪ 0202ｨｪ ｨｰ 08ｨｨ 08ｨｮ 06ｨｰ 0907 ｨｪｨｨ 0302 ｨｰ06 05ｨｹ ｨｺ06 ﾂｨｰ06 01ｨｨ ｨｪ - 02ｨｨ ｨ 09 03ｨｨ ｨｺ ｨｺ0502 ｨｰ06ｨｺ. 02ｨ 08ｨ 04ｨｮ 02ｨｰ ｨｺ ｨｪｨ 07, ｨｨ05ｨｨ ｨｰ02ｨｺ ｨｰ06 08ｨｨ ｨ 05ｨｹ ｨｪｨ 07, ｨｬ02ｨｬ ｨ 08ｨ ｨｪｨ 09 09ｨｨ 0102 ｨｺｨ ｨｦ ｨｬ04 ｨｪｨ ｨｺ ｨｬｨｨ ｨｺ0502ｨｰ ｨｺｨ ｨｬｨｨ. 02ｨｪｨ ｨｰｨ ｨｰ 0906 ｨ 06ｨｦ ｨ - 08ｨ 04 ｨｪｨｮ ｨｺ06ｨｪ 09ｨｨ 09ｨｰ02ｨｪ 02ｨｨｨｨ 0502ｨｪ ｨｰｨｮ. 00ｨｪｨｮｨｰ 0802ｨｪ ｨｪ0707 ｨ ｨｺｨ (in ner sul cus) 04ｨ ｨｪ02 ｨｪｨ ｨｰ ｨｰ04ｨｬ ｨ ｨｪ06ｨｬ ｨｨ ｨｺ02 08ｨ. 01ｨ ｨｰ0802 ｨｰｨｹ02ｨｦ 09ｨｰｨ 01ｨｨｨｨ (14 ｪ15 ｨｪ ｨｹ ｨ ｨｬ02ｨｪ ｨｪ06 09ｨｰｨｨ; ｨｮ ｨｬ ｨｦ 05ｨｰ06 2-ｨｦ 0102ｨｪｨｹ ｨｰ ｨｪｨ ｨｰｨ 05ｨｹ ｨｪ ｨ 04 09ｨｨ ｨｰｨｨ07) ｨｪｨ ｨｺ ｨｺ0502ｨｰ ｨｺｨ 01 09ｨｰ ｨｨ 05ｨｨｨｨ 0708ｨｨ 06ｨ 0802 ｨｰｨ 06ｨｰ ｨｺ06ｨｪ ﾂｨ - ｨｰ02 05ｨｹ ｨｪｨｮ ｨｬｨｮ ｨｨ ｨｪｨｨ02. 02ｨｨ ｨｪ 02ｨｨ 08ｨｮ 06ｨｰ ｨｰ0605ｨ ﾂｨ ｨｰ0402 (pil lar) ｨｺ0502ｨｰ ｨｺｨｨ ｨｬ07 05ｨｰｨｨ ｨｨ ｨｮ05ｨｨｨｰ - ｨｺｨ ｨｪｨ ｨｨ ｨ ﾂｨｮ09 09ｨｰ 09ｨｨ ｨｰ02 05ｨｹ ｨｪｨ ｨｺ 0102ｨｦ 09ｨｰ 09ｨｨ ｨ 06 ｨｴｨｨ01 00ｨ ｨｺ ｨｰ ﾁ02ｨｰ ｨｰｨ 07 09ｨｰｨ 01ｨｨ07 ｪ 09ｨｰ08ｨｮｨｺ ｨｰｨｮ08 ｨｪｨ 07, ｨｰ 0902ｨｰ 09ｨｰ 09ｨｮ 02ｨｰ ｨｪｨ - ﾂｨ 05ｨｮ 00ｨｮｨｪ ｨｺ 02ｨｨ 06 ｨｪｨｨ ｨ ｨｪｨｨ07 ｨｮ05ｨｨｨｰ ｨｺｨｨ (18 ｪ20 ｨｪ ｨｹ ｨ ｨｬ02ｨｪ ｨｪ06 09ｨｰｨｨ ｨｮ ﾂ ｨｺｨ ｨｨ 8-ｨｦ 0102ｨｪｨｹ ｨｰ ｨｪｨ ｨｰｨ 05ｨｹ ｨｪ ｨ 04 09ｨｨ - ｨｰｨｨ07 ｨｬ0403ｨｨ), ｨｬ020301ｨｮ 09ｨｪｨｮｨｰ0802ｨｪｨｪｨｨｨｬｨｨ ｨｨ ｨｪｨ 08ｨｮ03ｨｪ04ｨｬｨｨ 09ｨｰ0605ｨ ﾂｨ - ｨｰ04 ｨｬｨｨ ｨｺ0502ｨｰ ｨｺｨ ｨｬｨｨ 06ｨ 08ｨ 04ｨｮ 02ｨｰ 0907 ｨｰｨｮｨｪ ｨｪ0205ｨｹ ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ ｨｪｨ, ｨ ｨｬ ｨｮ ｨｪｨ 08ｨｮ03 ｨｪ04 ｨｬｨｨ 09ｨｰ0605ｨ ﾂｨ ｨｰ04 ｨｬｨｨ ｨｺ0502ｨｰ ｨｺｨ ｨｬｨｨ ｨｨ ｨｬ ｨｬ ｨｺ0502 ｨｰ06ｨｺ 0202ｨｦ ｨｰ ｨ 06ｨ 08ｨ 04ｨｮ 02ｨｰ ｨ 0601 ｨｪ04ｨｦ ｨｬ02 03ｨｮ ｨｰ06ｨｺ ｪ ｨｰ08ｨ ｨｪ 09ｨｰ ｨｮ ｨ ｨｪ ｨｨ ｨｺ02 08ｨ ｨｨ 08ｨｮ 02ｨｰ, ｨ ｨ 07 09ｨｪｨｮｨｰ 0802ｨｪ ｨｪ ｨｨ 08ｨ 05ｨｹ ｨｪｨｮ06 ｨ ｨｺｨｮ ｨｨ ｨｰ02ｨｺ ｨｰ06-08ｨｨ ｨ 05ｨｹ ｨｪｨｮ06 ｨｬ02ｨｬ ｨ 08ｨ ｨｪｨｮ. 0307ｨｰｨ 07 09ｨｰｨ 01ｨｨ07 ｪ ｨｺ06ｨｪ0202 ｨｬ ｨｨ ﾂ0209ｨｺ06ｨｦ 01ｨｨ ｨｪ - 02ｨｨ ｨｺｨｨ ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ ｨｪｨ (30 ｨｪ ｨｹ ｨ ｨｬ02ｨｪ ｨｪ06 09ｨｰｨｨ ｨｮ ｨ ﾂ ｨｺｨ ; 16 ｪ20-ｨｦ 0102ｨｪｨｹ ｨｰ ｨｪｨ ｨｰｨ 05ｨｹ ｨｪ ｨ 04 09ｨｨ ｨｰｨｨ07 ｨｮ ｨｬ040302ｨｦ ｨｨ ｨｺ080409) ﾂｨｰｨｨ ｨｪ0609ｨｰｨｹ06 ｨｨ09 ﾂ0204ｨ 06ｨｰ ｨｬｨｨｨｺ ｨｨｨｪｨｺｨｨ ｨｪ0609ｨｰｨｨ ｨｨ09ｨ 06ｨｴｨｨ01 ｨｨ 09ｨｰ0605ｨ ﾂｨ ｨｰ0401 ｨｺ0502 ｨｰ06ｨｺ. 05ｨ ｨ 02ｨｰ ｨｨ ｨｪｨ 05ｨｹ ｨｪｨ 07 09ｨｰｨ 01ｨｨ07 01ｨｨ ｨｪ 02ｨｨ ｨｺｨｨ ｨｪｨ 08ｨｮ03 ｨｪ ｨｺ ｨｺ0502 ｨｰ06ｨｺ (010008) ｨｨ 06ｨｺ08ｨｮ 03ｨ 06 - ｨｴｨｨ01 09ｨｰ08ｨｮｨｺ ｨｰｨｮ ｨ ｨｪ ｨｰｨｨ 06ｨｺｨ ｨ 02ｨｰ ｨｰ0607ｨｴｨｨｨｬ ｨｨ ｨｪ ｨ 09ｨｪｨｮｨｰ 0802ｨｪ ｨｪｨｨ ｨｺ ｨｺ0502 ｨｰ06ｨｺ (000008) ｨｨ ｨｰ (08ｨｨ 09ｨｮ ｨｪ06ｨｺ) ｨｰ0608 ｨｪ0402 ｨｺ0502ｨｰ ｨｺｨｨ 0706 ｨｺ06 07ｨｰ 0907 ｨｺｨ ｨｺ ｨｪｨ 0609ｨｪ06 09ｨ - ｨｪｨｨｨｨ ｨｪｨ ｨｰｨ ｨｺ ｨｪｨ ｨ 02 ｨｬ ｨｨ 09ｨ 06 ｨｴｨｨ01 ｨｺ0502ｨｰ ｨｺｨ ｨｦ - ｨｰ020809ｨ. 08ｨｮｨｰｨｨｨｺｨｮ050708ｨｪ ｨ 09ｨｰｨｨｨｪｨｺｨｨ ｨ 07ｨｨｨｺｨ 05ｨｹｨｪ06ｨｦ ｨｪ06-09ｨｰｨｨ ｨｺ ｨｺ0502ｨｰ06ｨｺ ｨｨ 06ｨｰ080609ｨｰｨｺ ｨｨ09ｨ 06ｨｴｨｨ01 ｨｺ0502 ｨｰ06ｨｺ 06ｨ 08ｨ 04ｨｮ 06ｨｰ 06ｨ ｨｴｨｮ ｨｰ ﾂｨ ｨｰｨｮ ｨ 09 ｨｰｨｨｨｪ ｨｺｨｮ, ｨｺ06 ｨｰ06 08ｨ 07 00ｨｨｨｺ 09ｨｨ 08ｨｮ 02ｨｰ ｨｪｨ 08ｨｮ03 ｨｪｨｮ ｨｪ0609ｨｰｨｹ ｨｺ0502 ｨｰ06ｨｺ ｨｨ 06ｨｺｨ ｨ 02ｨｰ 0907 ｨｪ ｨｪｨｨ 02ｨ 02 ｨｬ06ｨｦ ｨｪ ｨｨｨｬ ｨ 00ｨ 02ｨｰ 0907, ﾂｨｰ06 ｨｰｨｮｨｪ ｨｪ0205ｨｹ ｨｨ ｨｰ08ｨ ｨｪ 09ｨｰ 09ｨ 01ｨｮ ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ ｨｪｨ 04ｨ ｨｪ02 - ｨｪ ｨ 06ｨｦ 03ｨｨ01ｨｺ0609ｨｰｨｹ06 ｪ ｨｺ0608ｨｰｨｨ05ｨｨｨｬ0006ｨｦ, 06ｨｰ05ｨｨ ﾂｨ 06ｨｴ02ｨｦ ｨｰｨ 09ｨｮ 06ｨｰ ｨｨ05ｨｨｨｬ0004 ｨｨ 05ｨｪ010605ｨｨｨｬ ｨｪｨ ｨｨ ｨｰ02 05ｨｹ ｨｪ ｨｪ07 02ｨｰ ｨｰ ｨｨ ﾂ02 09ｨｺｨｮ06 00ｨｮｨｪ ｨｺ 02ｨｨ06. 06ｨｬ02ｨｪ ｨｪ06 06ｨｪｨ 06ｨｬ04 09ｨ 02ｨｰ 0609ｨｪ06 09ｨ ｨｪｨｨ ｨｪ ｨｪ ｨｺ ｨｺ0502 ｨｰ06ｨｺ. 08ｨ 07ｨｨ ｨｮ01ｨｨ09ｨｰ06ｨｦ ｨｺｨｨ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰｨｺｨｨ ｨｪ ｨｰ0902ｨｪｨｪ06 ｨｪ02 ｨｺ06ｨｪｨｰｨ ｨｺｨｰｨｨ08ｨｮ06ｨｰ 09 05ｨｪ010605ｨｨｨｬ0006ｨｦ. 02ｨｪｨ ｨｰ06-04ｨ ｨｰｨｨ 07ｨｨ ﾂ ｨｪ ｨ ｨ 04ｨ 05ｨｹ ｨｪ ｨｨｨｰ ｨｺｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｬ0502 ｨｺ06 07ｨｨ ｨｰｨ 06 ｨｴｨｨ01. 02ｨｨｨ ｨｬ02ｨｰ08 ｨｪｨ 08ｨｮ03 ｨｪ06ｨｦ ｨｺ ｨｦ ｨｺ0502ｨｰ ｨｺｨｨ 0708ｨｨ ｨｬ0208 ｨｪ06 7 mic rom. 03ｨｮ 09 ｨｰ ｨｰ08ｨ ｨｪ 09ｨｰ 09ｨ ｨｪ06 09ｨ ｨｪｨｨ 0701 ｨｪｨ 08ｨｮ03 ｨｪ ｨｺ ｨｺ0502 ｨｰ06ｨｺ 04ｨ ｨｪ07 ｨｰ ｨｪ ｨｰ ｨｪ04 ｨｬｨｨ 06ｨｺ06ｨｪ ﾂｨ ｨｪｨｨ 07 ｨｬｨｨ, ｨｺ06 ｨｰ ｨｪ02 09ｨｨ01 ｨｪ04 ｨｪｨ 08ｨｨ 09ｨｮｨｪ ｨｺ02: 1 ｪ ｨ ｨ 04ｨｨ050708ｨｪｨ 07 ｨｬ02ｨｬｨ 08ｨ ｨｪｨ ; 2 ｪ ｨｺ0502ｨｰｨｺｨｨ 0102ｨｪ0402ｨｪｨ ; 3 ｪ ｨｪｨ 08ｨｮ03ｨｪ ｨ 05ｨ ｨｪ0002ｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 0202ｨｦｨｰ020809ｨ ; 4 ｪ ｨｪ020809ｨｪ ｨｺ06ｨｪ ﾂｨ ｨｪｨｨ07; 5 ｪ ｨｪｨ 08ｨｮ03ｨｪ ｨｺ ｨｺ0502ｨｰｨｺｨｨ; 6 ｪ ｨｪｨ 08ｨｮ03ｨｪ ｨｨ08ｨ 05ｨｹｨｪ ｨｺｨｪｨ ; 7 ｪ ｨｪｨ 08ｨｮ03ｨｪ ｨｺ ｨｺ0502ｨｰｨｺｨｨ; 8 ｪ 09ｨｪｨｮｨｰ0802ｨｪｨｪｨｨｨｦ ｨｰｨｮｨｪｨｪ0205ｨｹ; 9 ｪ 09ｨｪｨｮｨｰ0802ｨｪｨｪｨｨ ｨｺ ｨｺ0502ｨｰｨｺｨｨ; 10 ｪ 09ｨｪｨｮｨｰ0802ｨｪｨｪｨｨ02 00ｨ 05ｨ ｨｪ0002ｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ; 11 ｪ ｨ ｨｪｨｨ ﾂｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ; 12 ｪ ｨｰ02ｨｺｨｰ0608ｨｨｨ 05ｨｹｨｪｨ 07 ｨｬ02ｨｬｨ 08ｨ ｨｪｨ ; 13 ｪ ｨｺ0502ｨｰｨｺｨ 0907ｨｨ08ｨ 05ｨｹｨｪ ｨ ｨｪ0005ｨｨ07 ｨｰｨｨ07ｨ I; 14 ｪ ｨｺ0502ｨｰｨｺｨ 0907ｨｨ08ｨ 05ｨｹｨｪ ｨ ｨｪ0005ｨｨ07 ｨｰｨｨ07ｨ II; 15 ｪ ｨｺ0609ｨｰｨｪｨ ｨｨ08ｨ 05ｨｹｨｪｨ 07 05ｨ ｨｬｨｨｨｪｨ ; 16 ｪ 0907ｨｨ08ｨ 05ｨｹｨｪ04ｨｦ ｨｺ ｨｪ0609ｨｪ04ｨｦ ｨｮ01; 17 ｪ ｨｰ02ｨｪ0606ｨ 08ｨ 04 - ｨｪ0402 ｨｺ0502ｨｰ ｨｺｨｨ; 18 ｪ ｨ ｨｺ 0906 ｨｪ04 ｨｺ0502ｨｰ ｨｺｨｨ 0907ｨｨ 08ｨ 05ｨｹ ｨｪ ｨ ｨｪ 00 05ｨｨ07 ( ｨｺ ｨｪｨ 0905ｨｮ ｨｪ ｨ ); 19 ｪ 08ｨ 01ｨｨ ｨ 05ｨｹ ｨｪ ｨｺ ｨｪｨ 4
3 ｨｨｨｰ ｨｨ04 ｨｰ ｨｨ ﾂｨｪ0401 ｨｰｨｨ ｨｺ0502ｨｰ06ｨｺ: ｨｬｨ 0800ｨｨｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 0507ｨｨ ｨｰ02 05ｨｨ ｨ 05ｨｹ ｨｪ ｨｨ ｨｪｨｨ07, ｨｺ06ｨｪ ｨｰｨ ｨｺ ｨｰｨｨ - 08ｨｮ06ｨｴｨｨ ｨｪ ｨｨｨｬ 0006ｨｦ; ｨ ｨ 04ｨ 05ｨｹ ｨｪ0401 ｨｺ0502 ｨｰ06ｨｺ ｨｬ ｨｪ 01ｨｨｨｬ ｨｪ ｨｨ ｨｪｨｨ07, 06ｨ 08ｨ 04ｨｮ06ｨｴｨｨ01 ｨｪ ｨｪ04ｨｦ ｨｦ, ｨｰｨｨ05ｨ 06ｨｴｨｨｨｦ 0907ｨｨ08ｨ 05ｨｹｨｪｨｮ06 05ｨｨ00ｨ ｨｬ02ｨｪｨｰｨｮ, ｨｨ ｨｬ0205ｨ ｨｪ0602ｨｨｨｰ ｨ ｨｪ ｨｬ02 03ｨｮ ｨｰ06 ﾂ ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ, ｨｨ 01ｨｨ ｨｬ06 ｨｬｨｮ, ｨｨ ｨｴｨｨ01 ｨｨ04 ｨｺ0502 ｨｰ06ｨｺ ｨｪ ｨｪ ｨ ｨｪ07 ｨｨ 08ｨ 04 ｨ ｨ ｨｪｨｪ0401 ｨｬ ｨｮ ｨ ｨ 04ｨ 05ｨｹ ｨｪ04 ｨｬｨｨ ｨｨ ｨｬｨ 08 00ｨｨ ｨｪｨ 05ｨｹ ｨｪ04 ｨｬｨｨ ｨｺ0502ｨｰ ｨｺｨ ｨｬｨｨ [93] ｨｨ000208ｨ 02ｨｨ ｨｨ ｨ 02ｨｨ07 06ｨ ﾂｨｨ 09ｨ 02ｨｰ ｨｪｨ ｨｬｨｨ, 06ｨｰ 0902 ﾂｨ 06 ｨｴｨｨ - ｨｬｨｨ 04ｨ ｨｬｨｨ ｨｰ06 ｨｰｨｨ ﾂ02 09ｨｺｨｨ , 05ｨｰ06 06ｨ ﾂｨｨ 09ｨ 02ｨｰ ｨｰ ｨｨ 04ｨ ｨｺ08ｨｮ ﾂｨｨ 09ｨ ｨｪｨｨ ｨｮ ｨｦ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｰ ｨｪ06, ﾂｨｰ06 ｨｺ06ｨｪ 0202ｨｪ ｨｰ - 08ｨ 02ｨｨ 06ｨｪ ｨｪ04ｨｦ 0008ｨ 01ｨｨ 02ｨｪｨｰ ｨ 0205 ｨｺｨ So nic hed ge hog (Shh) ｨｹ ｨ 07ｨｨ ｨｺｨ 05ｨｹ ｨｪ06-ｨ ｨ 04ｨ 05ｨｹ ｨｪ06ｨｦ 0609ｨｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨ 02ｨｰ ｨｨｨｰ ｨｪ ｨｨｨｪ 0108ｨｮ 0006 ｨｬｨｮ 0008ｨ 01ｨｨ 02ｨｪ ｨｰ04 ｨ ｨｺ ｨｰｨｨ 09ｨ ｨｰ GLI fa mi ly zinc fin ger (Gli) ｨｨ ｨ Gli3 [3]. 02ｨ 08ｨ ｨ ｨｪｨｨ02 ｨ 07ｨｨ ｨｺｨ 05ｨｹ - ｨｪ06ｨｦ ﾂｨ 09 ｨｰｨｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｨ ｨｨｨｰ ｨｪｨ ｨｨ ｨ ｨ 05ｨｨ04 ｨｺ06 ｨｺ ｨｨ09 ｨｰ06 ﾂ - ｨｪｨｨ ｨｺｨｮ Shh ｨｨ ｨｪｨｮ03 01ｨ 02ｨｰ ｨｨ 05ｨｹ ｨｪ06ｨｬ 0102ｨｦ 09ｨｰ 09ｨｨｨｨ ｨ ｨｺ ｨｰｨｨ 09ｨ ｨｰ06 08ｨ Gli, 06ｨ ﾂｨｨ 09ｨ 02 ｨｬ06ｨｦ ｨｺｨｨ ｨｬｨｨ ｨｮ ｨｪ07 ｨｬｨｨ ｨ ﾂｨｨ 09ｨｨ00 ｨｪｨ Shh. 07 ｨｬｨｮ ｨｰｨ ｨｪ ｨｰ ｨｪｨ 08ｨｮ 0302 ｨｪｨｨ 02ｨｬ 00ｨｮｨｪ ｨｺ 02ｨｨｨｨ ｨ ｨｺ ｨｰｨｨ - 09ｨ ｨｰ06 08ｨ Gli ｨ 07ｨｨ ｨｺｨ 05ｨｹ ｨｪｨ 07 ﾂｨ 09ｨｰｨｹ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｪ02 06ｨ 08ｨ 04ｨｮ 02ｨｰ 0907 ｨｨ ｨｺｨ - ｨｪｨ 05 06ｨｺｨ ｨ 02ｨｰ 0907 ｨｮｨｺ ﾂ02ｨｪ ｨｪ04ｨｬ [6, 22]. 01ｨ ｨｰｨｨ09, ｨ ｨ - 04ｨ 05ｨｹ ｨｪｨ 07 ﾂｨ 09ｨｰｨｹ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ 08ｨ 04 09ｨｨ 09ｨ 02ｨｰ ｨ ｨｰ 09ｨｮｨｰ - 09ｨｰ 09ｨｨ ｨ ﾂｨｨ 09ｨｨ00 ｨｪｨ Shh ｨ ｨｰ02 05ｨｹ ｨｪ06, ｨｦ - 09ｨｰ 09ｨｨ 02ｨｬ 05ｨｰｨｨ01 ｨｬ ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨｨ ｨ 01ｨｨ 02ｨｪ ｨｰ0609 ｨｨ 0609ｨｮ ｨｴ02 09ｨｰ ｨｰ 0907 ｨｪｨ 0708ｨ ｨｪ ｨｪ04ｨｦ ｨｰ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ. 01ｨ ｨｬ ｨｪ0204 ｨｨ ｨｰ ｨｮ05ｨｨｨｰ ｨｺｨｨ 06ｨｺｨ ｨ 06ｨｰ 0905ｨｨ 07 ｨｪｨｨ02 ｨｰｨ ｨｺ ｨ 01 ｨｪｨｨｨｦ ｨｬ ｨｨ ｨｬ ｨｪ 01ｨｨ ｨｬｨ [57]. 01ｨ 08ｨｮ 0302 ｨｪｨｨ ｨｰｨ 0802ｨｦ 09ｨｪ ｨｺ06ｨｦ ｨｬ02ｨｬ ｨ 08ｨ ｨｪ04 ｨｮ ｨｬｨｮ ｨｰｨ ｨｪ - ｨｰ0609 orthodenticle homolog 2 (Otx2) ｨｨ ｨｮ01ｨｨ09ｨｰ06ｨｦ ｨｺｨｨ ｨｮ ｨｬｨｮ ｨｰｨ ｨｪ ｨｰ0609 Pa i red box ge ne 2 (Pax2), 06ｨ 08ｨ 04ｨｮ06ｨｴｨｨ01 09ｨｰ02ｨｪｨｺｨｨ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ, ｨ 02ｨｰ 09ｨ 06ｨｦ ｨｰｨ ｨ ﾂｨ ｨｰ ｨｺｨ 0905ｨｮ ｨｦ ｨｮ05ｨｨｨｰ ｨｺｨｨ [9, 71]. 03ｨｴ00 09ｨｨ 05ｨｹ ｨｪ0202 ｨｪｨ ｨｰ 0905ｨｨ07 06ｨｰ ｨｪｨ 08ｨｮ ｨｪｨｨ ｨｪ0609, 05ｨｺ ｨｨ08ｨｮ06ｨｴｨｨ ｨ ｨ 04ｨｨ050708ｨｪ06ｨｦ ｨｬ02ｨｬｨ - 08ｨ ｨｪ02 ｨｨ 09 08ｨ ｨｪ ｨｪ06ｨｬ ｨｪｨ ｨｪ02ｨｦ 04ｨ ﾂｨ ｨｰ ｨｺ02 ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ ｨｪｨ [8, 51, 52, 74]. 01ｨ 0708ｨｨ ｨｬ0208, ｨ ﾂｨ 09ｨｨ00 ｨｪｨ bo ne mor p - ho ge ne tic pro te in 4 (Bmp4) ｨｰ ｨ 03 ｨｪ04ｨｬ ｨｬ02ｨｪ ｨｰ06ｨｬ ｨｮ ｨｨｨｨ ｨｺ06 05ｨｨ ﾂ02 09ｨｰ 09ｨ ｨｨ 01ｨｨ ｨｪ 02ｨｨ ｨｺｨｨ ｨｺ ｨｺ0502 ｨｰ06ｨｺ [56, 77], ｨｰ ｨｨ ｨ ｨｰｨｨ09 ｨｪ ｨ. 01ｨ 08ｨｮ ｨｪｨｨ02 ｨ ｨｺ ｨｰｨｨ09 ｨｪ06 09ｨｰｨｨ ｨｰ06 08ｨ Bmp, Nog gin [11, 30] ｨｰｨ ｨｺ ｨｹ ｨｬ ｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨ ｨｪ06ｨｬｨ 05ｨｨ07ｨｬｨｨ, ｨ ｨｨｨｨ ｨ ｨｪ ｨｪ04 ｨｬｨｨ ｨｺ ｨｰｨ ｨｬｨｨ ｨｰｨ ｨ ﾂｨ 09ｨｨ00 ｨｪｨ fib - roblast growth factor (FGF), 06ｨ ﾂｨｨ09ｨ 02ｨｬｨ ｨｬ06ｨｴｨｹ ｨｰ06 08ｨ FGFR1, ｨｰｨ ｨｺ 0302 ｨｨ00 08ｨ 02ｨｰ ｨｹ ｨｰ0208 ｨｬｨｨ ｨｪｨ 02ｨｨｨｨ 08ｨ 04 ｨｬ02 08ｨ 07ｨｮ 05ｨ ｨｰ 0902ｨｪ ｨｪｨｨ ｨｺ ｨｮ ｨｰ02ｨｬ ｨｮ 05ｨｨ ｨ ｨｪｨｨ ｨｨ ｨ 02ｨｨｨｨ ｨｺ0502 ｨｰ06ｨｺ [75] ｨｰ ｨｺｨｨ ｨｰ 0902ｨｪ ｨｪｨｨ ｨｺｨｨ ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ ｨｪｨ ｨｮ ｨｬ ｨｦ ｨｰ ｨｨ04 ｨｺ0502 ｨｰ06 ﾂ ｨｪ ｨｨｨｺ 05ｨ ｨｬ ｨｮ 09ｨｰｨ 01ｨｨ 07 ｨｬｨｨ 05ｨｬ ｨ 08ｨｨ ｨｪ0204ｨ 0312 ｨｨ 0316 [84]. 02ｨｪｨｨ 06ｨ 08ｨ 04ｨｮ06ｨｰ 0406ｨｪｨｮ ｨｪ ｨｨ000208ｨｨ08ｨｮ - 06 ｨｴｨｨ01 ｨｺ0502 ｨｰ06ｨｺ, ｨｺ06 ｨｰ06 08ｨ 07 ｨｬｨ 08 ｨｺｨｨ 08ｨｮ 02ｨｰ 0907 p27 Kip1 ｨｨ p19 Ink4d, 0102ｨｦ 09ｨｰ 09ｨｮ 06 ｨｴｨｨ ｨｬｨｨ ｨｺｨ ｨｺ ｨｨｨｪ 00ｨｨ ｨ ｨｨ ｨｰ ｨ ｨｺ0502 ｨｰ06 ﾂ ｨｪ ｨｨｨｺ 05ｨ [54, 65]. 0709ｨｰｨ ｨｪ ｨｪｨ ｨｹ ｨｬ ｨｮ ｨｰ08ｨ ｨｪ 09ｨｰ 0902ｨｪ ｨｪ04ｨｬ ｨｨ ｨｬ02ｨｪ ｨｪ04ｨｬ 07ｨ ｨｰ ｨｰ0208 ｨｪ06ｨｬ ｨｰ08ｨ ｨｪ09 ｨｺ08ｨｨ07 02ｨｨｨｨ 0002ｨｪｨ p27 Kip1 ｨｨ ｨｺ06ｨｪ - ｨｰ ｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ ｨｰｨｬｨｨｨｰ06ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｰ0902ｨｪｨｪｨｨ - ｨｺ0609, ｨｪｨ 04 ｨｪｨ ﾂ02ｨｪ ｨｪ ｨ 09ｨ ｨｰｨｹ ｨｺ ｨｨ ｨｨ 09ｨ - 06 ｨｴｨｨ02 ｨｺ0502ｨｰ ｨｺｨｨ ｨ ｨｪｨ ｨｰｨｨ [54]. 03ｨ ｨｰ ｨｰ0208ｨｪ 05ｨｺ ｨｨｨｨ ｨｪｨ p27 Kip ｨｺｨ ｨ 02ｨｰ, ﾂｨｰ ｨｰ 0902ｨｪ ｨｪｨｨ ｨｺｨｨ 09ｨｰｨ ｨｪ ｨｰ ｨｰｨｬｨｨｨｰ06ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ 09 ｨｪｨ 0708ｨ ｨｪｨｨｨｨ 06ｨｰ ｨｮ03ｨｺｨｨ ｨｺ 0609ｨｪ06-09ｨ ｨｪｨｨ06 08ｨ 04 09ｨｨ 09ｨ 06 ｨｴ02ｨｦ 0907 ｨｮ05ｨｨｨｰ ｨｺｨｨ [49, 54]. 06ｨｪ ｨｰ ｨｪ06, ﾂｨｰ ｨｰｨｬｨｨｨｰ06ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｰ0902ｨｪｨｪｨｨｨｺｨｨ 09 ｨ 07ｨｨｨｺｨ 05ｨｹｨｪ06ｨｦ 06ｨ - 05ｨ 09 ｨｰｨｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｪ02 01ｨｨ ｨｪ 02ｨｨ 08ｨｮ 06ｨｰ 0907, 0706 ｨｺｨ ｨｺ0502ｨｰ - ｨｺｨｨ ｨｰ0902ｨｪｨｪｨｨｨｺｨｨ ｨｪ02 09ｨｰｨ ｨｪｨｮｨｰ ｨｰｨｬｨｨｨｰ06ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ. 07 p27 Kip1 -ｨｬｨｮ ｨｰｨ ｨｪ ｨｰ ｨｪ ｨｨ 0906ｨｰ ｨｪ0401 ｨ ｨｨ ｨｰ02 05ｨｹ ｨｪｨ 07 ｨｬｨｨ ｨｰ06 ｨｰｨｨ ﾂ02 09ｨｺｨ 07 ｨ ｨｺ ｨｰｨｨ09 ｨｪ0609ｨｰｨｹ 09 08ｨ 04 09ｨｨ 09ｨ 06 ｨｴ02ｨｬ 0907 ｨｺ0608 ｨｰｨｨ ｨｬ ｨ ｨｪ ｨ 02ｨｰ 06ｨ 08ｨ ｨ ｨｪｨｨ02 ｨｨ04 ｨ 04 ｨｰ06 ﾂ ｨｪ ｨｪ ｨｪ0401 ｨｨ ｨｨ09ｨ 06ｨｴｨｨ01 ｨｺ0502ｨｰ06ｨｺ. 0709ｨｰｨ ｨｪ ｨｪ06, ﾂｨｰ ｨｪ Insulin-like growth factor 1 (IGF-1) ｨｺ06ｨｪ ｨｰ ｨｨ 08ｨｮ 02ｨｰ 05ｨｺ ｨｨ06 ｨ 0205 ｨｺｨ ｨｨ ｨｪｨｮ ｨｺｨ 05ｨｨ 04ｨ 02ｨｨ06 For k he ad box pro te in M1 (FoxM1), ｨｺ06 ｨｰ ｨｦ ｨｬ0209ｨｰｨｪ06 05ｨｺ ｨｨ08ｨｮ02ｨｰ ｨｨ000208ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ ｨｺｨ 01, ｨ 0601 ｨｪ06ｨｦ ｨｨ ｨｬｨｨ 0302 ｨｪ02ｨｦ ｨｰ ｨｪ p27 Kip1 [86]. IGF-1 ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｰ 05ｨｺ ｨｨ06 ｨｨ 0108ｨｮ00ｨｨ01 ｨ 0205ｨｺ0609 ｨｺ0502 ｨｰ06 ﾂ ｨｪ ｨｨｨｺ 05ｨ, ｨｰｨ ｨｺｨｨ01, ｨｺｨ ｨｺ In ner cen t ro me re pro te in (INCENP). 06ｨｰ06 ｨｮｨｺｨ ｨ 02ｨｰ ｨｪｨ ｨｰ06, ﾂｨｰ06 ｨｮ ｨｬｨｮ ｨｰｨ ｨｪ ｨｰ0609 IGF-1 ｨ ｨ 05ｨ ｨｪ09 ｨｬ ｨｮ ｨｺ0502 ｨｰ06 ﾂ ｨｪ06ｨｦ ｨｨ ｨ 02ｨｨ02ｨｦ, 03ｨｨ04 ｨｪ ｨ - ｨｪ0609ｨｰｨｹ06 ｨｨ 01ｨｨ ｨｪ02ｨｨ080609ｨｺ06ｨｦ ｨｪｨ 08ｨｮ0302ｨｪ [86] ｨｺ prb ｨｰｨ ｨｺ 0302 ｨｪ02 06ｨ ｨｨｨｬ ｨ ｨｨ04 ｨｺ0502 ｨｰ06 ﾂ ｨｪ ｨｨｨｺ 05ｨ ｨｰ 0902ｨｪ ｨｪｨｨ ｨｺ ｨｺ ｨｺ0502 ｨｰ06ｨｺ ｨｬ0502 ｨｺ06 07ｨｨ ｨｰｨ 06 ｨｴｨｨ01 [85] ｨｰｨｺｨ ｨｪ ｨ ｨｨ ｨｬ ｨｦ 09ｨｰ 09ｨｨ ｨｰ ｨｨ ｨｬ ｨｪ ｨｮ ｨｦ ｨｮ05ｨｨｨｰｨｺｨｨ ｨｬ0502ｨｺ0607ｨｨｨｰｨ 06ｨｴｨｨ ｨｮ 05ｨｨ 08ｨｮ 02ｨｰ ｨ ｨｨ ｨｬ ｨｦ 09ｨｰ 09ｨｨ 07 ｨｬｨｨ ｨｬ ｨｮ 0905ｨｮ ｨｬ 0507ｨｨ ｨｰ02-05ｨｨ02ｨｬ ｨｨ 06ｨｺ08ｨｮ03ｨ 06ｨｴ02ｨｦ ｨｨ06ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｬ020402ｨｪ01ｨｨｨｬ06ｨｦ [25, 76]. 0102ｨｪ Bra in 4 (Brn-4/Pou3f4) 05ｨｺ ｨｨ08ｨｮ02ｨｰ ｨｬ020402ｨｪ01ｨｨｨｬ ｨｪ06ｨｦ ｨｰｨｺｨ ｨｪｨｨ, 06ｨｺ08ｨｮ 03ｨ 06 ｨｴ02ｨｦ 08ｨ 04 09ｨｨ 09ｨ 06 ｨｴ ｨｪｨｮｨｰ 0802ｨｪ ｨｪ0202 ｨｮ0106, ｨｪ06 ｨｪ ｨｮ ｨｬ 0507ｨｨ ｨｰ02 05ｨｨｨｨ ｨｪｨ ｨｺ06 ｨｮ ｨｬｨｮ ｨｰｨ ｨｪ ｨｰ ｨｪ0401 ｨｬ040302ｨｦ Brn-4/Pou3f4 06ｨ ｨｪｨ 08ｨｮ 03ｨｨ 09ｨ 06ｨｰ ｨｺ ｨｰ04 ｨｬ ｨｪ02 04ｨ 09ｨｪｨｮｨｰ 0802ｨｪ ｨｪ ｨｮ01ｨ, 09ｨｺ0506 ﾂｨ 07 ｨｮｨｬ02 ｨｪｨｹ 0302 ｨｪｨｨ02 ｨｺ06 05ｨｨ ﾂ02 09ｨｰ - 09ｨ 04ｨ 09ｨｨｨｰ ｨｺ0609 ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｨ ｨｪｨ 08ｨｮ 0302 ｨｪｨｨ07 01ｨｨ ｨｪ 02ｨｨ ｨｺｨｨ 06ｨｰｨｨ - ﾂ0209ｨｺｨｨ01 00ｨｨｨ ｨｨｨｰ0609 [7, 76]. 0906ｨｪ ｨｨｨｰ ｨｨ00ｨｨ ﾂ0209ｨｺｨ ｨｨ ｨｪｨ Mot hers aga inst de ca pen tap le gic ho mo log 4 (Smad4) 0905ｨｨ 07 05ｨ ｨｪｨ 0507ｨｨ ｨｰ02 05ｨｨｨｦ 09ｨｪｨｮｨｰ 0802ｨｪ ｨｪ ｨｮ01ｨ : 08ｨ 04 09ｨｨ ｨｰｨｨ02 09ｨｰ ｨｨ05ｨｨｨｦ 06ｨｺｨ 04ｨ ｨｹ ｨｪｨ 08ｨｮ0302ｨｪ06, 09ｨｨｨｪｨ ｨｪ02ｨｦ0806ｨｪ ｨｨ 08ｨ 05ｨｹ ｨｪ ｨ ｨｪ 00 05ｨｨ ｨｺ ｨｬｨｨ ｨｺ0502ｨｰ ｨｺｨ ｨｬｨｨ 06ｨ ｨｪｨ 08ｨｮ - 03ｨｨ 09ｨ 05ｨｨ ｨ ｨｪ06 ｨｬｨ 05ｨｹ ｨｪ04ｨｦ ｨｬ ｨｪ ｨｰ ｨ 0506 ｨｰ ｨｮ06 ｨｪ02ｨｦ ｨｪ ｨｪｨｮ ｨｰ ｨｮ 01ｨ [104]. 0102ｨｪ Eyes ab sent ho mo log 1 (Eya1) ｨｰｨ ｨｺ ｨｺ ｨｨ08ｨｮ02ｨｰ ｨｬ ｨｪ 01ｨｨ ｨｬ02, 06ｨｺ08ｨｮ 03ｨ 06 ｨｴ02ｨｦ ｨｺｨ ｨｪｨ 05 ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｨ ｨｰｨｨ ｨ ｨｮ ｨｪｨｮ06 09ｨｨ 09 ｨｰ02 ｨｬｨｮ, ｨｨ ｨｬ ｨｰ ｨ 04ｨｰｨｹ ｨｪ02 06ｨ ｨｨｨｬ ｨｨ ｨｪ 02ｨｨ ｨｺｨｨ 05ｨｰｨｨ01 ｨｰｨｨ ｨｺ0502 ｨｰ06ｨｺ ｨｴ [45] ｨｪｨ ｨｺ ｨｪ Eya1 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｪ0206ｨ ｨｨｨｬ ｨｨ ｨ ﾂｨｨ 09ｨｨ00ｨｪｨ ｨｬ ｨｮ ｨｬ ｨｪ 01ｨｨ ｨｬ06ｨｦ ｨｨ 0905ｨｮ ｨｬ 07ｨｮ ｨｹ ｨｺ06ｨｬ, ｨｺ06 ｨｰ06 08ｨ 07 09ｨｮ ｨｴ02 09ｨｰ 0902ｨｪ ｨｪｨ ｨｬ ｨｪ02 04ｨ 09ｨｪｨｮｨｰ 0802ｨｪ ｨｪ ｨｮ01ｨ. 06ｨｰ06 06ｨ ｨｲ ｨｪ07 02ｨｰ ｨｰ ｨｪｨ 08ｨｮ 0302 ｨｪｨｨ07 09ｨｪｨｮｨｰ 0802ｨｪ ｨｪ ｨｮ01ｨ ｨｮ 07ｨ 02ｨｨ 02ｨｪ ｨｰ ｨｨｨｪ ｨｬ06ｨｬ Bran c hio-oto-re nal (BOR). 0102ｨｪ SRY (sex de ter mi ning re gi on Y)-box 9 (SOX9) ｨｮ ｨｬ ｨｦ 03ｨｨ 0806 ｨｺ06 05ｨｺ ｨｨ 08ｨｮ 02ｨｰ ｨｨ 06 ｨｰｨｨ ﾂ02 09ｨｺ06ｨｦ ｨｬ ｨｪ 01ｨｨ ｨｬ02, ｨｴ ｨｦ ｨｺｨ 07 09ｨｮ 0502 ｨｨ ｨｮ ｨｬ 0507ｨｨ ｨｰ02 05ｨｨｨｨ [62]. 0102ｨｪ T-box 1 (Tbx1) ｨｰｨ ｨｺ ｨｺ ｨｨ 08ｨｮ 02ｨｰ 0907 ｨｺｨ ｨｺ ｨｮ ｨｬ 0507ｨｨ ｨｰ02 05ｨｨｨｨ, ｨｰｨ ｨｺ ｨｨ ｨｨ 06 ｨｰｨｨ ﾂ02 09ｨｺ06ｨｦ ｨｬ ｨｪ 01ｨｨ ｨｬ ｨｬ ｨｪ 01ｨｨ ｨｬ ｨｪ Tbx1 ｨｪ02 06ｨ ｨｨｨｬ ｨｨｨｪ 01ｨｮｨｺ 02ｨｨｨｨ 05ｨｺ ｨｨｨｨ ISSN
4 ﾁ ｨｪｨ Brn-4/Pou3f ｨｨ 00ｨｨ ﾂ ｨｪｨ ｨｬ ｨｪ 01ｨｨ ｨｬ ｨｨ07 Tbx ｨ 02ｨｰ ｨｪｨ 08ｨｮ 0302 ｨｪｨｨ ｨｨ ｨｰ02 05ｨｨｨｨ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ - ｨｺｨｨ [101]. 06ｨｺ ｨｨ ｨｪｨ Tbx ｨｨ 06 ｨｰｨｨ ﾂ02 09ｨｺ06ｨｦ ｨｬ ｨｪ - 01ｨｨ ｨｬ02 04ｨ 09ｨｨ 09ｨｨｨｰ 06ｨｰ 0002 ｨｪｨ Shh [81], ｨｰ06 ｨｬｨｮ ｨｬ ｨｺｨｮ ｨｪ04ｨｦ 07ｨｮｨｰｨｹ Shh-Tbx1-Brn ｨｨ 06 ｨｰｨｨ ﾂ02 09ｨｺ06ｨｦ ｨｬ ｨｪ 01ｨｨ ｨｬ02 ｨｬ ｨｰ ｨｮ ﾂｨ 09ｨｰ ｨ ｨｰｨｹ 09 06ｨ ﾂ02 ｨｪｨｨｨｨ ｨｬｨｨ ｨ ｨｪｨｨ ｨｨ ｨｰ02-05ｨｨ ｨ 05ｨｹ ｨｪ ｨ ｨｰ ｨｰ0208 ｨｪｨ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｪ 01ｨｨ ｨｬｨ ｨｰｨ ｨｺ 0302 ｨｮ ﾂｨ 09ｨｰ 09ｨｮ 02ｨｰ ｨｬｨｨ ｨ ｨｪｨｨｨｨ 05ｨ ｨｰ02 08ｨ 05ｨｹ ｨｪ06ｨｦ 09ｨｰ02ｨｪ ｨｺｨｨ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ, ｨｰｨ ｨｪ ｨｪ06ｨｦ 06ｨｰｨｨ ﾂ02 09ｨｺｨｨ ｨｬｨｨ 00ｨｨｨ ｨｨ ｨｰｨ ｨｬｨｨ ｨｨ ｨｮ 01ｨｨ 09ｨｰ06ｨｦ ｨｺ06ｨｦ ｨｪ 01ｨｨｨｬ ｨｪ04ｨｦ 0002ｨｪ Tbx18 06ｨｰ 0902 ﾂｨ - 02ｨｰ 04ｨ ｨｬ ｨｪ 01ｨｨｨｬ ｨｪ ｨｨ ｨｰ02 05ｨｨ ｨ 05ｨｹ ｨｪ04ｨｦ ｨｨ ｨｬｨｨ ｨ ｨｪｨｨｨｨ ｨ ｨ 04ｨ 05ｨｹ ｨｪ0401 ｨｺ0502 ｨｰ06ｨｺ ｨｮ 01ｨｨ 09ｨｰ06ｨｦ ｨｺｨｨ ｨｺｨ ｨｪｨ 05ｨ ｨｨ 04ｨ 01ｨｨ ｨｪ 02ｨｨ ｨｺｨｮ 06ｨｰｨｨ ﾂ02 09ｨｺｨｨ01 00ｨｨｨ ｨｨ ｨｰ0609 [4]. 0102ｨｪ Oto spi ra lin, ｨｺ06 01ｨｨ 08ｨｮ 06 ｨｴｨｨｨｦ ｨ ｨｺ 09ｨｪ02 ｨｺ0502 ｨｰ06 ﾂ ｨｪ ｨｬｨ ｨｰ 08ｨｨｨｺ - 09ｨ, ｨｰｨ ｨｺ ｨｺ ｨｨ 08ｨｮ 02ｨｰ ｨ ｨｰ02 08ｨ 05ｨｹ ｨｪ06ｨｦ 09ｨｰ02ｨｪ ｨｺ02 ｨｺｨ ｨｪｨ 05ｨ ｨｨ ｨｨ00 08ｨ 02ｨｰ 09ｨ 03 ｨｪｨｮ ｨｹ 09 08ｨ 04 09ｨｨ ｨｰｨｨｨｨ 06ｨｰｨｨ ﾂ02 09ｨｺｨｨ01 00ｨｨｨ ｨｨ - ｨｰ0609 [20] ｨｨ 06 ｨｰｨｨ ﾂ02 09ｨｺ06ｨｦ ｨｬ ｨｪ 01ｨｨ ｨｬ02 06ｨ ｨｪｨ 08ｨｮ 03ｨｨ 09ｨ 02ｨｰ 0907 ｨｰｨ ｨｺ ｨｺ ｨｨ ｨｪｨ ｨｰ06 08ｨ FGF, Fgfr4, ｨｪｨ ﾂｨｨ ｨｪｨ ｨｰｨ 01ｨｨｨｨ [38] ｨｬ07 06ｨ 08ｨ ｨ ｨｪｨｨ ｨｴ ｨｦ ｨｺｨ 07 09ｨｮ 0504 ｨｮ05ｨｨｨｰ ｨｺｨｨ 09ｨｨ00 ｨｪｨ 05ｨｹ ｨｪ0402 ｨｬ ｨｺｨｮ 0504, ｨｨ09 07ｨｮ 09ｨｺｨ 02 ｨｬ ｨｮ ｨｬ 0507ｨｨ ｨｰ02 05ｨｨ - 02ｨｬ, ｨｦ 09ｨｰ ｨｪ04, ｨｰｨ ｨｺ ｨｨ07 06ｨｰ ｨｪｨ ｨｨ 06 ｨｰｨｨ ﾂ02 09ｨｺｨｮ06 ｨｬ ｨｪ 01ｨｨ ｨｬｨｮ, ﾂｨｰ06 ｨ 04 06ｨ ﾂｨｨｨｰｨｹ ｨｰｨｺｨ ｨｪ02 09ｨｮ06 ｨｨｨｪ 01ｨｮｨｺ 02ｨｨ06 ｨｨ 01ｨｨ ｨｪ 02ｨｨ ｨｺｨｮ ｨｬ ｨｪ 01ｨｨ ｨｬ ｨｴ [11, 26, 27]. 06ｨｺ ｨｰ06-07ｨｨ ﾂ0209ｨｺｨ 07 05ｨｺ ｨｨ ｨｰ0607ｨｪｨｪ06 ｨ ｨｺｨｰｨｨ09ｨｪ Bone morp - ho ge ne tic pro te in re cep tor ty pe-1b (Bmpr1b) ｨｨｨｪ 01ｨｮ 02ｨｨ 08ｨｮ 02ｨｰ ｨｴ ｨｰ04, ｨｰ ｨ ｨｺｨ ｨｺ 0106 ｨｬｨｨ ｨｪｨ ｨｪ ｨｰ ｨｪ06-ｨｪ02 00ｨ ｨｰｨｨ09 ｨｪｨ ｨｬｨ 05ｨｰ ｨｰ06 08ｨ ｨ 02ｨｰ 0706 ｨｰ ｨｴｨ 09 ｨｺｨ 07 09ｨｮ ｨｮ05ｨｨｨｰｨｺｨｨ. 06ｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ ｨｬｨｨ080609ｨ ｨｪｨｨ ｨｴｨ ｨｰｨ ｨｺ ｨｨ ｨｨｨｰ 09 06ｨｰ 0902ｨｰ ｨｪｨ ｨｦ 09ｨｰ 09ｨｨ02 00ｨ ｨｺ ｨｰ06 08ｨ Nog gin, 0902ｨｺ ｨｰｨｨ08ｨｮ02ｨｬ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ Bmp [58]. 02ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ02 05ｨｺ ｨｨｨｨ 0002 ｨｪｨ Fgf ｨｦ 09ｨｪ ｨｺ06ｨｦ ｨｬ02ｨｬ ｨ 08ｨ ｨｪ ｨ 02ｨｰ ｨｺｨｰ04 09 ｨｬ020402ｨｪ01ｨｨｨｬ ｨｨ05ｨｨｨｬ00ｨ ｨｰｨｨ ﾂ0209ｨｺ ｨｰ08ｨ ｨｪ09ｨｰ09ｨ [75]. 01ｨ ｨｺ06 ｨｪ0202, ｨｬｨｮ ｨｰｨ 02ｨｨｨｨ 0002ｨｪ0609, ｨ 06 ｨｴｨｨ02 ｨ ｨｪ06 ｨｬｨ 05ｨｹ - ｨｪｨｮ06 01ｨｨ ｨｪ 02ｨｨ ｨｺｨｮ 0907ｨｨ 08ｨ 05ｨｹ ｨｪ ｨ ｨｪ 00 05ｨｨ07, ｨｰｨ ｨｺｨｨ01, ｨｺｨ ｨｺ ne u ro ge nin 1 (Ngn1) ｨｨ05ｨｨ Ne u rod1, 0708ｨｨ ｨｰ ｨｺ ｨｪｨ 08ｨｮ 0302 ｨｪｨｨ - 07ｨｬ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ [53, 60, 61, 65]. 0806ｨｪ ｨｪｨｰｨｪ0602 ｨｮ0105ｨｨｨｪ02ｨｪｨｨ ｨ ｨｪｨｨ ｨｨ ｨ 02ｨｨｨｨ ｨｮ ｨｬ ｨｦ ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ E14.5-E ｨｰｨｬｨｨ ｨｰ06 ｨｰｨｨ ﾂ02 09ｨｺｨｨｨｦ 0507ｨｨ ｨｰ02 05ｨｨｨｦ ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ ｨｪｨ ｨｨ09 ｨｰ06ｨｪ ﾂｨ 02ｨｰ 0907 ｨｨ ｨｰ0605 ｨｴｨｨ ｨｪ06ｨｦ 09 4 ｪ5 ｨｺ0502 ｨｰ06ｨｺ 09 00ｨｨ ｨｪｨ 05ｨｹ ｨｪｨｮ ｨｮ ｨｦ ｨｪｨｮ06 09ｨｰ08ｨｮｨｺ ｨｰｨｮ 08ｨｮ ｨｨ ｨｮ01-05ｨｨ ｨｪ07 02ｨｰ 0907 [13, 66] ｨｰ06 ﾂ ｨｪ ｨｬ02 ｨｴ02 ｨｪｨｨ07 ｨｰｨ ｨｺ ｨｰｨｨ 07ｨ ｨｪ ｨｬ ｨｺ06ｨｪ ｨｪ ｨｰ ｨｪ ｨｮ01 05ｨｨ ｨｪ02 ｨｪｨｨ07 (con- ver gent ex ten si on). 09ｨ 08ｨ ｨｺ ｨｰ0208 ｨｪ04ｨｬ ｨｮ07 07ｨｨ ｨｺｨｨ ｨｺ0502 ｨｰ06ｨｺ 0708ｨｨ ｨｺ06ｨｪ ｨｪ ｨｰ ｨｪ06ｨｬ ｨｮ01 05ｨｨ ｨｪ02 ｨｪｨｨｨｨ (0807) ｨｰ 0907 ｨｰ06, ﾂｨｰ06 ｨｺ0502ｨｰ ｨｺｨｨ ｨｪ ｨ ｨ 0507ｨｰｨｹ ｨｨ ｨｨ ｨｪｨｨ - ｨｬｨｨ ｨｺ0502ｨｰ ｨｺｨ ｨｬｨｨ ｨｨ 0708ｨｨ 06ｨ 0802 ｨｰｨ ｨｰｨｹ ｨ ｨｨ ｨｪｨｮ ｨｨ 04ｨ 02ｨｨ ｨｺ 0609ｨｨ 0904 ｨｰ07 00ｨｨ 09ｨ ｨｪｨｨ ｨｨ ｨｰ02 05ｨｨ ｨ 05ｨｹ ｨｪ ｨｨ 04ｨ 02ｨｨ07 ｨｰｨ ｨｺｨｨ01 ｨｺ0502 ｨｰ06ｨｺ 01ｨ 08ｨ ｨｺ ｨｰ02 08ｨｨ 04ｨｮ 02ｨｰ ｨｪｨｨ 02ｨｬ ｨｪｨ ｨｰｨｨ ｨｪ ｨ 01 06ｨｰ ｨｰ ｨｺ0609, ｨｺ06 ｨｰ ｨｰ ｨｺ0502ｨｰ ｨｺｨ ｨｬ ｨｬ02 ｨｴｨ ｨｰｨｹ ｨｺ 0609ｨｨ 0904 ｨｰ07 00ｨｨ 09ｨ ｨｪｨｨ ｨｨ ﾂ02 09ｨｺｨｨ02 ｨｨ 00ｨｮｨｪ ｨｺ 02ｨｨ 06 ｨｪｨ 05ｨｹ ｨｪ0402 ｨｨ ｨ ｨｪｨｨ ｨｰ ｨ 06ｨｰ, ﾂｨｰ06 ｨｬ02 01ｨｨ 06 05ｨ ｨｰ02 08ｨ 05ｨｹ ｨｪ0402 ｨｨｨｪ ｨｰ0208 ｨｺｨ ｨｨｨｨ ｨｺ0502 ｨｰ06ｨｺ, 01ｨ 08ｨ ｨｺ ｨｰ0208 ｨｪ , 09ｨｺ , ｨｮ ﾂｨ 09ｨｰ 09ｨｮ 06ｨｰ ｨｺ08ｨ ｨｴ02 ｨｪｨｨ ｨｨ ｨ 02ｨｨｨｨ 09 ｨｮ01 05ｨｨ ｨｪ02 ｨｪｨｨｨｨ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｨ ｨｬｨｨ ｨ ｨｪｨｨｨｨ 07ｨ ｨｰ ｨｰ0208 ｨｪｨ ｨｺ ｨｺ0502 ｨｰ06ｨｺ [44, 66, 68, 95]. 00ｨｮ ｨｰｨ ｨｪ ｨｰ ｨｪ0402 Math1 -/- (mo u se ho mo log of the Dro sop hi la pro ne u ral ge ne ato nal) 03ｨｨ 0906ｨｰ ｨｪ0402 ｨｪ02 06ｨ ｨｪｨ 08ｨｮ 03ｨｨ 09ｨ 05ｨｨ 01ｨｨ ｨｪ 02ｨｨ ｨｺｨｨ ｨｺ ｨｺ0502 ｨｰ06ｨｺ ｨｨ 0106 ｨｪ02 ｨｺ06 ｨｰ ｨｦ 09ｨｰ ｨｪｨｨ ｨｨ 09ｨ 06 ｨｴｨｨ01 ｨｺ0502 ｨｰ06ｨｺ [4, 13, 65, 97], ｨｪ06 ｨｮ05ｨｨｨｰ ｨｺｨ ｨｮ ｨｬｨｮ - ｨｰｨ ｨｪ ｨｰ0609 ｨｨｨｬ02 05ｨ ｨｪ0608 ｨｬｨ 05ｨｹ ｨｪｨｮ ｨｨ ｨｪｨｮ. 06ｨｰ06 ｨｮｨｺｨ ｨ 02ｨｰ ｨｪｨ ｨｰ06, ﾂｨｰ06 06ｨ 08ｨ ｨ ｨｪｨｨ ｨｪ ｨｪｨ ｨ 0608ｨ ｨｺ ｨｨ ｨｨ 09ｨ 06 ｨｴｨｨ01 ｨｺ0502 ｨｰ06ｨｺ ｨｪ02 09ｨｮ ｨｴ02 09ｨｰ 0902ｨｪ ｨｪ ｨ 0807 ｨｮ05ｨｨｨｰ ｨｺｨｨ. 01ｨ 0108ｨｮ 00ｨｨ01 09ｨｨ 09 ｨｰ02 ｨｬｨ ｨｪ ｨｺ08ｨｮ ｨｪ0609, ｨｮ ﾂｨ 09ｨｰ - 09ｨｮ 06 ｨｴｨｨ ｨｰｨｨ ｨｺ02 ｨｺ0502 ｨｰ06ｨｺ. 02ｨｺｨ 04ｨ ｨｹ, ﾂｨｰ06 ｨ 06 05ｨｹ - 03ｨ 07 ﾂｨ 09ｨｰｨｹ 0002 ｨｪ0609, ｨｮ ﾂｨ 09ｨｰ 09ｨｮ 06 ｨｴｨｨ , 04ｨ 0102ｨｦ 09ｨｰ ｨ ｨｪｨ ｨｰｨ ｨｺ ｨ ｨｨ06ｨ 0802ｨｰ02ｨｪｨｨ ｨｺ0609ｨｰｨｪ06ｨｦ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｪ0609ｨｰｨｨ (030803). 01ｨ 0708ｨｨｨｬ0208, 09 06ｨ 06ｨｨ ｨ 01 ｨｮ ﾂｨ - 09ｨｰ 09ｨｮ 06ｨｰ ｨｮｨｺｨｰ 0002 ｨｪｨ Win g less-ty pe MMTV in teg ra ti on si te fa mi ly, mem ber 5A (Wnt5a) ｨｨ ｨｰ0608 ｨｪｨ 07 ｨｰｨｨ ｨｨｨｪ ｨｺｨｨ ｨｪｨ 04ｨ re cep tor-re la ted 2 (Ror2). Wnt5a -/- ｨｬ04 03ｨｨ [79] ｨｨ Ror2 -/- ｨｬ04 03ｨｨ [102] 06ｨ 05ｨ 01ｨ 06ｨｰ ｨｪ ｨ 09ｨｨ 05ｨｹ ｨｪ ｨｨ 02ｨｪ ｨｰｨｨ ｨ ｨｪｨｪ04ｨｬｨｨ 09ｨｰ ｨｨ05ｨｨ07ｨｬｨｨ ｨｨ 0002ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ 06ｨｰｨｺ0506ｨｪ02 - ｨｪｨｨ 07 ｨｬｨｨ 09 ｨｮ05ｨｨｨｰ ｨｺ02 (ｨｮｨｺ ﾂ02 ｨｪｨｨ02 ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｨ ｨｮ ｨｨ ﾂ02 - ｨｪｨｨ02 ｨｺ06 05ｨｨ ﾂ02 09ｨｰ 09ｨ ), ｨｮｨｺｨ ｨ 07 ｨｰ02ｨｬ 09ｨ ｨｬ04ｨｬ, ﾂｨｰ06 ｨｨ ｨｨ ｨｬ02 ｨｴ02 ｨｪｨｨ07 ｨｪ02 ｨｮ ｨｮ 05ｨｨ ｨ ｨｪ ｨｺｨ - 04ｨ ｨｪ06, ﾂｨｰ ｨｪ Ror2 ｨｪ02 06ｨ ｨｨｨｬ Wnt5a-ｨｨｨｪ 01ｨｮ 02ｨｨ ｨ ｨｪ - ｨｪ06ｨｦ ｨｨ040609ｨ ｨｪｨｪ06ｨｦ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｬｨｨ0008ｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ, ｨｺ06ｨｰ06-08ｨ 07 06ｨ ﾂｨｨ 09ｨ 02ｨｰ ｨｮ ｨｰ02ｨｬ ｨ ｨｺ ｨｰｨｨ 09ｨ 02ｨｨｨｨ c-junn-ter mi nal ki - na se ｨｰ 0906ｨｬ ｨ ｨｺ ｨｰｨｨｨｪ ｨ 06 ｨｴ ｨ 0205 ｨｺｨ 00ｨｨ 05ｨ ｨｬｨｨ - ｨｪｨ 08 [72]. 00ｨｮ ｨｰｨ 02ｨｨｨｨ ｨｪ02 ｨｬｨｨ 06 04ｨｨ ｨｪｨ Myo2 [103] ｨｰｨ ｨｺ 0302 ｨｪｨ - 08ｨｮ 03ｨ 06ｨｰ ｨ ｨｰ02 05ｨｹ ｨｪ06, 0807 ｨｪｨｮ03 01ｨ 02ｨｰ ｨ ｨｺ ｨｰｨｨ ｨｪ06/ｨｬｨｨ ｨｨｨｪ060906ｨｦ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ02 02ｨｨｨｰ0609ｨｺ020502ｨｰｨ. 07ｨｺ ﾂ02 ｨｪｨｨ02 ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｪ ｨｬ02ｨｪ ｨｪ04ｨｬ ｨｮ ｨｨ - ﾂ02 ｨｪｨｨ 02ｨｬ ｨｺ06 05ｨｨ ﾂ02 09ｨｰ 09ｨ ｨｺ ｨｨ05ｨｨ 09ｨｰ0605ｨ ﾂｨ ｨｰ0401 ｨｺ0502 ｨｰ06ｨｺ ｨｪｨ ｨ ｨ 02ｨｰ ｨｨ ｨｬｨｮ ｨｰｨ 02ｨｨ ｨｪ0609, 06ｨｰ 0902 ﾂｨ 06 ｨｴｨｨ01 04ｨ ｨｨ , ｨｰｨ ｨｺｨｨ01, ｨｺｨ ｨｺ vang-li ke 2 (Vangl2) [67], dishevelled homolog (Dvl)1, Dvl2 [95], Myo2 [103], ｨ ｨｰｨ ｨｺ 0302 ｨｰｨ ｨｺｨｨ ｨｪ0609, ｨｺｨ ｨｺ For k he ad box pro te in G1 (Foxg1), Gli3 ｨｨ Shh [6, 13] ｨｰｨｨ 0002 ｨｪ04 ｨｺｨ ｨｺｨｨｨｬ-ｨｰ06 06ｨ 08ｨ 0406ｨｬ 0904ｨ ｨｨ ｨｬ ｨｦ 09ｨｰ - 09ｨｮ06ｨｰ ｨｬ020301ｨｮ 0906ｨ 06ｨｦ, ﾂｨｰ06ｨ 04 06ｨ ﾂｨｨｨｰｨｹ ｨ ｨｺ, 0002ｨｪ Wnt5a 0904ｨ ｨｨ ｨｬ ｨｦ 09ｨｰ 09ｨｮ 02ｨｰ 09 ｨｨ ｨｰ ｨｪ04ｨｬ ｨｪ06ｨｬ lo - op-tail (Ltap)/Vangl2, ｨ 09ｨｰ09ｨｮ ｨｮ050702ｨｨｨｨ 0608ｨｨ02ｨｪｨｰｨ 02ｨｨｨｨ 09ｨｰ ｨｨ 05ｨｨｨｦ (030803), ｨｮ01 05ｨｨ ｨｪ02 ｨｪｨｨ06 ｨｮ05ｨｨｨｰ ｨｺｨｨ (0807) [79] ｨｨ09 ｨｪ ｨｦ 09ｨｰ 09ｨ ｨｺ0502 ｨｰ06ｨｺ 09 ｨｮ05ｨｨｨｰ ｨｺ02 ｨｰｨ ｨｺ 0302 ｨｬ06 00ｨｮｨｰ ｨ 04ｨｰｨｹ ｨｺ08ｨｨ - ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｬｨｨ ｨｨ ｨｬ060502ｨｺｨｮ050708ｨｪ04ｨｬｨｨ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰｨ - ｨｬｨｨ ｨｮ0708ｨ ｨｪｨｨ ｨｰ0806ｨｦ ｨｺｨｨ ｨｺ0502 ｨｰ06ｨｺ. 07 ｨｬ ｨｦ, ｨｪ02 09ｨｮ ｨｴｨｨ01 ｨｬｨｮ ｨｰｨ 02ｨｨｨｨ ｨｪ06ｨｬ ｨｨ ｨｮ01 Notch 05ｨｨ 00ｨ ｨｪ , Jag ged-2 (Jag2) ｨｨ Del ta-li ke 1 (Dll1), 06ｨ ｨｪｨ 08ｨｮ 03ｨｨ - 09ｨ 06ｨｰ 0907 ｨｮｨｺ ﾂ02ｨｪ ｨｪ04ｨｦ ｨｺｨ ｨｪｨ 05 ｨｮ05ｨｨｨｰ ｨｺｨｨ 09 ｨｮ ｨｨ ﾂ02 ｨｪｨｨ 02ｨｬ ｨｺ06 05ｨｨ - ﾂ02 09ｨｰ 09ｨ ｨｺ ｨｺ0502 ｨｰ06ｨｺ [8, 51], ｨ ｨｰｨ ｨｺ 0302 ｨｪ ｨ - 09ｨｨ05ｨｹｨｪｨ ｨｨ02ｨｪｨｰｨ 02ｨｨ07 09ｨｰ ｨｨ05ｨｨｨｦ ｨｺｨ ｨｪ ｨｪ06, ｨｺｨ ｨｺｨ ｨｨ ﾂｨｨ ｨｪｨ ｨ 02ｨｰ ｨｰｨｨ ｨｺｨｮ ｨｺ0502 ｨｰ06ｨｺ ｨｨ ｨｺ06ｨｪ ｨｪ ｨｰ ｨｪ ｨｰ07 00ｨｨ 09ｨ ｨｪｨｨ02 ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ - ｨｺｨｨ ｨｬ0603ｨｪ06, 05ｨｰ06 06ｨ ﾂｨｨ09ｨ 02ｨｰ0907 ｨｬ ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬ 0008ｨ 01ｨｨ 02ｨｪ ｨｰ06ｨｬ 09 ｨｬ02 01ｨｨ 06 05ｨ ｨｰ02 08ｨ 05ｨｹ ｨｪ06ｨｬ ｨｪｨ 0708ｨ ｨｪｨｨｨｨ 09 04ｨ ﾂｨ ｨｰ ｨｺ02 ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ ｨｪｨ, ｨｪｨ 0708ｨｨ ｨｬ0208 Bmp4 [70]. 6
5 ｨｺ06 09ｨｰｨｪｨ 07 ｨｺ0502ｨｰ06 ﾂｨｪｨ ｨｪ0609ｨｰｨｹ ｨｬ07 ｨｰ0208 ｨｬｨｨ ｨｪｨ 05ｨｹ ｨｪ06ｨｦ 01ｨｨ ｨｪ 02ｨｨ ｨｺｨｨ ｨｨ ｨｮ01 05ｨｨ - ｨｪ02 ｨｪｨｨ07 ｨｺ0608 ｨｰｨｨ ｨ ｨｪｨ 0609ｨｮ ｨｴ02 09ｨｰ ｨｰ ｨｪｨ ｨｪｨｨ07 ｨｺ0502ｨｰ06ｨｺ ｨｺ0609ｨｰｨｪ06ｨｦ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｪ0609ｨｰｨｹ06 (030803) (pla nar cell po la ri ty) ｨｪｨｨ 02ｨｬ ｨｹ ｨｪ06 09ｨｰｨｨ ｨｺ ｨｺ0502 ｨｰ06ｨｺ 0905ｨｮ 03ｨｨｨｰ 08ｨ ｨｪｨｨ02 ｨｪｨ ｨｪｨｨ01 09ｨｰ ｨｨ05ｨｨｨｦ ｨｨ ﾂｨｪｨ ｨｪｨｨ ﾂｨｺｨ, ｨｺｨｨｨｪ0602ｨｨ05ｨｨｨｦ (ki no ci li um), ｨ ｨｪｨ 08ｨｮ 03ｨｨ 09ｨ 02ｨｰ ｨｪ ｨｰ ｨｮ03 - ｨｺｨｨ 01ｨｨ ｨｪ 02ｨｨ 08ｨｮ 06 ｨｴ02ｨｦ ｨｺ ｨｦ ｨｺ0502ｨｰ ｨｺｨｨ ｨｨ 06ｨｺ08ｨｮ ｨｪｨ ｨｬｨｨｨｺ ｨｨｨｪ ｨｺｨ ｨｬｨｨ. 05ｨ ｨｰ02ｨｬ 05ｨｰｨｨ ｨｬｨｨｨｺ ｨｨｨｪ ｨｺｨｨ ｨｪｨ ﾂｨｨ - ｨｪｨ 06ｨｰ ｨｮ090205ｨｨ ﾂｨｨ09ｨ ｨｰｨｹ0907 ｨｨ 09ｨｰｨ ｨｪ060907ｨｰ ｨｰ ｨｨ05ｨｨ07ｨｬｨｨ. 08ｨｨｨｪ06-02ｨｨ 05ｨｨｨｦ 09ｨｬ02 ｨｴｨ 02ｨｰ ｨ ｨｰ02 08ｨ 05ｨｹ ｨｪ06 ｨｪｨ ｨｪ06 09ｨｰｨｨ ｨｺ0502ｨｰ ｨｺｨｨ, ｨ 09ｨｰ ｨｨ 05ｨｨｨｨ ｨｰ08ｨ ｨｨ 09ｨ 06ｨｰ ｨｨ ｨ 08ｨ ｨｺ ｨｰ0208 ｨｪ V-06ｨ - 08ｨ 04ｨｪ ｨ ｨｰｨｰ0208ｨｪｨ 09 ｨｰ06 ﾂｨｺ06ｨｦ ｨｨｨｪ02ｨｪｨｨ07 V, ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴ02ｨｦ ｨｺｨｨ ｨｪ06 02ｨｨ 05ｨｨ06 [29]. 01ｨ 09ｨｰｨ 01ｨｨｨｨ E18.5 ｨｮ ｨｬ ｨｦ ｨｨ ｨ ｨｪｨｪ ｨ ｨｪｨｨ02 09ｨｰ ｨｨ05ｨｨｨｦ ｨｨ ｨｺｨｨｨｪ0602ｨｨ05ｨｨ07 ｨｮ09ｨｰｨ ｨｪｨ 09 05ｨｨ 09ｨ 02ｨｰ ｨｺ ｨｺ0502ｨｰ ｨｺｨ ﾂ ｨｪ06ｨｬ ｨｪｨ ｨ ｨｪｨｨｨｨ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｦ ｨｨ ｨｪ ｨｨｨｬ ｨｬ02ｨｰ - 08ｨｨ ﾂｨｪｨ ｨｨ080601ｨ V-06ｨ 08ｨ 04ｨｪ06 08ｨ ｨｪｨｪ ｨｰ ｨｨ05ｨｨｨｦ 06ｨｰ 08ｨ 03ｨ 02ｨｰ ｨｨ ｨ ｨｪ ｨｪｨｮ06 09ｨｰ08ｨｮｨｺ ｨｰｨｮ 08ｨｮ 09ｨｪｨｮｨｰ 08ｨｨ ｨ 07ｨｨ ｨｺｨ 05ｨｹ ｨｪ ｨｰ ｨ ｨｺｨ ｨｦ ｨｺ ｨｦ ｨｺ0502ｨｰ ｨｺｨｨ ｨｰ , ｨｰ ｨｨ 05ｨｨｨｨ, ｨｮｨｪｨｨ ｨｬ ｨｪ ｨｨ 02ｨｪ ｨｰｨｨ ｨ ｨｪ ｨｪ ｨｹ ｨｬ02-01ｨｨ0605ｨ ｨｰ0208ｨ 05ｨｹｨｪ06ｨｦ 0609ｨｨ ｨｮ05ｨｨｨｰｨｺｨｨ, 0102ｨｬ06ｨｪ09ｨｰ08ｨｨ08ｨｮ06ｨｰ ｨｺ ｨｨｨｪｨ - 02ｨｨ ｨ ｨｪｨｨｨｨ ｨｨ 09ｨ ｨｬｨｨ01 ｨｺ0502ｨｰ06ｨｺ 0601ｨｪｨ 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ ｨｮ 0006ｨｦ 09ｨｪｨｮｨｰ 08ｨｨ 0008ｨｮ ｨｰｨ ｨｪ ｨｪｨ ｨｹ ｨｬ ｨｮ 0608ｨｨ 02ｨｪ - ｨｰｨ 02ｨｨ02ｨｦ ｨｪｨｨ ﾂ02ｨｺ ｨｨ ｨ ﾂ02ｨｦ 09ｨｨ00 ｨｪｨ [44, 73, 83], 09 ﾂｨ 09ｨｰ ｨｪ06 09ｨｰｨｨ ｨｪｨ ｨｬｨｨ Inturned ｨｨ Fuzzy ｨｰｨ ｨｪ ｨｪｨｨ ｨｪｨｮ03 01ｨ 02ｨｰ ｨｪ06ｨｦ ｨｮ ｨｨｨｨ [92] ｨ 09 ｨｪ ｨｪ06ｨｦ ｨｨ04 ｨ 05ｨｹ ｨｰ0208 ｨｪｨ ｨｰｨｨ09 ｨｪ0401 ｨｬ ｨｦ, ｨｪ02 06ｨ ｨｨ ｨｬ ｨ ｨ 05ｨｹ ｨｪ0402 ｨｪｨ ｨｴｨｨ02 09ｨｨ00 ｨｪｨ 0504, ｨ 06ｨｴｨｨ02 ｨｨｨｪ000608ｨｬｨ 02ｨｨ06 06 ｨｪｨ 0708ｨ ｨｪｨｨｨｨ ｨｨ04ｨ 02ｨｨｨｨ ( ｨｰ06 07 ｨｴｨｨ ｨｪ ), ｨｨ ｨｺ0502 ｨｰ06 ﾂ ｨｪ ｨ ｨｺ ｨｰ ｨｨｨｪ - ｨｰ ｨｰｨ 02ｨｨｨｨ ｨｪｨ 0708ｨ ｨｴｨｨ01 09ｨｨ00 ｨｪｨ (09ｨｰ ｨｪ ｨｪ ) ｨｬｨｨ ｨ ｨｪｨｨ ｨｨ ｨ ｨｪ ｨｪ ｨｰ ｨｪ ｨｺ06ｨｬ ｨｺ ｨｰ0802 ｨｰｨｹ07 ｨｨ 00ｨｨ ｨｪｨ 05ｨｹ ｨｪｨ 07 09ｨｰｨｮ 0702ｨｪｨｨ ｨｨ04ｨ 02ｨｨｨｨ ｨｺ ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨｺ0608ｨｰｨｨ0209ｨ ｨ ｨｪｨ ｨｪ ｨｰｨｨ00ｨ ｨｰｨｹ ｨｬ06ｨｴｨｹ06 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｨ00ｨｨ ﾂ0209ｨｺｨｨ ｨｺ ｨｰ , 09ｨｰ06 07 ｨｴｨｨ01 ｨｨ0208ｨ 08 01ｨｨ ﾂ02 09ｨｺｨｨ ｨｪｨｨ ｨｰ ｨｪ ｨｪ (ｨｪｨｨ ｨｰ06 07 ｨｴｨｨ ｨｪ ｨｺ ｨｰ ), ｨｺ06 ｨｰ ｨｰ 0902 ﾂｨ 06ｨｰ 0906ｨ 09ｨｰ 0902ｨｪ ｨｪ06 04ｨ ｨｬｨｨ ｨ ｨｪｨｨ02 ｨ 09ｨｨｨｬ ｨｬ02ｨｰ 08ｨｨ ﾂ - ｨｪ ｨｰ08ｨｮｨｺ ｨｰｨｮ08 09ｨｪｨｮｨｰ 08ｨｨ ｨｺｨ ｨｦ ｨｺ0502ｨｰ ｨｺｨｨ ｨｨ ｨｺ ｨｨ ｨｪｨｨ 08ｨｮ 06ｨｰ ｨｨ04ｨ 02ｨｨ06 ｨｺ0502ｨｰ06ｨｺ ｨｺ ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨ 09ｨｪ ｨｮ ｨｦ ｨｬ ｨｨ, ｨ 07 07ｨ 08ｨ ｨｰ, ｨｺ06 ｨｰ ｨｦ 09ｨｰ0806 ｨｨｨｰ ｨ 09ｨｨｨｬ ｨｬ02ｨｰ 08ｨｨ ﾂ ｨｪ ｨｰ08ｨｮｨｺ ｨｰｨｮ ｨｪｨｮｨｰ 08ｨｨ ｨｺｨ ｨｦ ｨｺ0502ｨｰ ｨｺｨｨ, ｨｪ02 04ｨ 09ｨｨ 09ｨｨｨｬ 06ｨｰ ｨ - ﾂｨｨ 09ｨｨ00 ｨｪｨ ｨｰ06 07 ｨｴｨｨ ｨｪ ｨｬ ｨｦ, ｨｺ ｨｰ ｨｪ ｨｰ ｨｪ ｨｬ 0002 ｨｪｨ ｨｬ , 09ｨｺ0506 ﾂｨ ｨｪ04 Ltap/Vangl2, Dvl1/2, Friz zled (Fz3/6) ｨｨ Celsr1, ｨｦ 09ｨｰ 09ｨｨ ｨｰ02 05ｨｹ ｨｪ06 09ｨｰｨｨ 06ｨ ｨｪｨ 08ｨｮ 03ｨｨ 09ｨ 06ｨｰ ｨｺ ｨｰ ｨ ｨｪｨｨｨｨ ｨｺ0502 ｨｰ06ｨｺ ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ ｨｪｨ ｨｨ 08ｨ 04 05ｨｨ ﾂ ｨｪ ｨｰ ｨｪｨｨ ｨｪ020708ｨ 09ｨｨ05ｨｹｨｪ06ｨｦ 0608ｨｨ02ｨｪｨｰｨ 02ｨｨｨｨ 09ｨｰ ｨｨ05ｨｨｨｦ [15, 45, 68, 69, 94] ｨｰ 0902ｨｰ 09ｨｰ 09ｨｨｨｨ ｨｦ ｨｬ ｨｹ ｨｪｨ ｨｺ06 ｨｮ ﾂｨ 09 ｨｰｨｨ ｨｬ ｨｦ, ｨｺ ｨｰ ｨｪ ｨｰ ｨｪ ｨｬ 0002 ｨｪｨ ｨｬ , ｨｬ ｨｰ ｨ ｨｪ07ｨｰ0907 V-06ｨ 08ｨ 04ｨｪ ｨ ｨｪｨｨ02 09ｨｰ ｨｨ05ｨｨｨｦ. ﾁｨｰ06 ｨ ｨｨ 02ｨｪ ｨｰｨｨ ｨ ｨｰｨｹ 09ｨｰ ｨｨ 05ｨｨｨｨ ｨｮｨｪｨｨ ｨｬ ｨｪ ｨｹ ｨｬ02 01ｨｨ 06 05ｨ ｨｰ02 08ｨ 05ｨｹ ｨｪ06ｨｦ 0609ｨｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ, ｨｪｨ 0708ｨｨ 09ｨｮｨｰ 09ｨｰ ｨ ｨｰｨｹ ｨｨｨｪ ｨｬｨ 02ｨｨ07, ｨｴｨ 07 05ｨｰ06 ｨｪｨ 0708ｨ ｨｪｨｨ ｨｬ07 08ｨ 04 09ｨｨ ｨｰｨｨ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 09ｨｨ00 ｨｪｨ 05ｨｹ ｨｪ04ｨｦ 07ｨｮｨｰｨｹ Rac-PAK (p21-ｨ ｨｺ ｨｰｨｨ 09ｨｨ 08ｨｮ 02 ｨｬ06ｨｦ ｨｺｨｨ ｨｪｨ 0404) ｨｪ02 06ｨ ｨｨｨｬ ｨ 09ｨｨ 05ｨｹ ｨｪ ｨｬｨｨ ｨ ｨｪｨｨ07 07ｨ ｨｰ ｨｰ0208 ｨｪｨ 09ｨｰ ｨｨ 05ｨｨｨｦ [31] ｨ ｨ ｨｪｨｨ02 Wnt-ｨ ｨｪ ｨｰｨ 0006 ｨｪｨｨ 09ｨｰ ｨｺｨｮ 05ｨｹ ｨｰｨｮ 08ｨｮ ｨｺ0608 ｨｰｨｨ ｨ ｨｪｨ 0708ｨｨ ｨｨ 0506 ｨｺ ｨｪ ｨ 09ｨｨ 05ｨｹ ｨｪ06ｨｦ 0608ｨｨ 02ｨｪ ｨｰｨ 02ｨｨｨｨ 09ｨｰ ｨｨ 05ｨｨｨｦ in vit ro [16]. 06ｨｪ ｨｰ ｨｪ06, ﾂｨｰ06 Wnt-ｨ ｨｪ ｨｰｨ ｨｪｨｨ09ｨｰ, 0902ｨｺ 0802 ｨｰｨｨ 08ｨｮ 02 ｨｬ04ｨｦ Friz zled-re la ted pro te in 3 (Sfrp3 ｨｨ05ｨｨ Frzb), 05ｨｺ ｨｨ 08ｨｮ 02ｨｰ ｨｨ ｨｨ ｨｺ ｨｪ ｨ 01ｨｨ - 02ｨｪ ｨｰｨ ｨｰ ｨｪ ｨｪｨｨ06 ｨｺ ｨｰｨ ｨｺ ｨｬｨｮ ｨ 0205 ｨｺｨ Wnt5a 09 08ｨ 04 09ｨｨ 09ｨ - 06 ｨｴ02ｨｬ ｨ ｨｪ ｨｰｨｨ [79] ｨｪｨ ｨｺ06 ｨｪ ｨｪ06, ｨｬ ｨｰ 05ｨｨ ｨｨ ｨｺ ｨｪｨ 07 05ｨｺ ｨｨ07 ｨ 0205 ｨｺｨ Wnt5a ｨｨ Wnt-ｨ ｨｪ ｨｰｨ 0006 ｨｪｨｨ - 09ｨｰｨ ｨｮ ﾂｨ 09ｨｰ ｨ ｨｰｨｹ ｨｪ02 08ｨ 02ｨｨｨｨ 0008ｨ 01ｨｮ ｨｨ ｨ ｨｪ ｨｪ ｨｨ00 ｨｪｨ 05ｨ Wnt ｨｪ02 ｨｪｨｨ07 ｨｨｨｪ 09ｨｰ 08ｨｮｨｺ ｨｰｨｨ09 ｨｪ06ｨｦ ｨｨ ｨ ﾂ02 09ｨｨ00 ｨｪｨ ｨｹ ｨｬ02 01ｨｨ06-05ｨ ｨｰ02 08ｨ 05ｨｹ ｨｪ06ｨｦ 0609ｨｨ ｨｰ ｨｨ ｨｬ02 01ｨｨ ｨ ｨｰ ｨｨ00 ｨｪｨ 05ｨｹ ｨｪ ｨｮ ｨｰ02ｨｦ hed ge hog (Hh) ｨｨ pla te let de ri ved growth fac tor re cep tor (PDGFR), ｨｬ ｨｪ06, ｨｰｨ ｨｺ ｨ ﾂｨｨ 09ｨ 06ｨｰ ｨｬ ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨｨ ｨ 01ｨｨ 02ｨｪ ｨｰ04 09 ｨｮ05ｨｨｨｰ ｨｺ02 [14, 39, 59, 87]. 06ｨ ｨｺ, ｨ ｨｮ09ｨｰｨ ｨｪ ｨｪ06, ﾂｨｰ06 Hh 0102ｨｦ 09ｨｰ 09ｨｮ 02ｨｰ 09ｨｬ02 09 ｨｰ02 09 Wnt ｨｺｨ ｨｺ ｨｺ06ｨｬ ｨｺ ｨｰ06 07 ｨｴｨｨ01 09ｨｨ00 ｨｪｨ 05ｨｹ ｨｪ0401 ｨｬ ｨｺｨｮ05, ｨｮ ﾂｨ 09ｨｰ 09ｨｮ 06 ｨｴｨｨ ｨ ﾂ02 09ｨｨ00 ｨｪｨ [81, 82]. 08ｨ ｨｺ ｨｰ0608 BMP4, 0601ｨｨｨｪ ｨｨ04 ﾂ0502 ｨｪ ｨｬ02ｨｦ 09ｨｰ 09ｨ TGF-1 7, ｨｺｨ ｨｺ ｨｮ0302 ｨｮｨｺｨ ｨ ｨｹ, 05ｨｺ ｨｨ08ｨｮ02ｨｰ0907 ｨ 09ｨｨｨｬｨｬ02ｨｰ08ｨｨ ﾂｨｪ ｨｨ - ｨｰ02 05ｨｨｨｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｪ02 ｨｰ06 05ｨｹ ｨｺ ｨｹ ｨｹ ｨｪ06ｨｦ, ｨｪ06 ｨｨ ｨｬ02 01ｨｨ 06-05ｨ ｨｰ02 08ｨ 05ｨｹ ｨｪ06ｨｦ 0609ｨｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ [70]. 00ｨｪ ｨｰ 0902ｨｪ ｨｪ0402 FGF-05ｨｨ - 00ｨ ｨｪ 0104 ｨｨ ｨｰ /ｨｬ02 01ｨｨ ｨ ｨｰ ｨｰｨ ｨｺ ｨｺ ｨｨ 08ｨｮ 06ｨｰ ｨｮ05ｨｨｨｰ ｨｺ ｨｬ07 ｨｰ0208 ｨｬｨｨ ｨｪｨ 05ｨｹ ｨｪ06ｨｦ 01ｨｨ ｨｪ 02ｨｨ ｨｺｨｨ [28, 75, 89] ｨｪｨ ｨｺ06, ｨｬ06 00ｨｮｨｰ 05ｨｨ 06ｨｪｨｨ ｨｰｨ ｨｺ 0302 ｨｪ ｨｰ 0902ｨｪ ｨｪ ｨｮ 05ｨｨ ｨ ｨｰｨｹ ｨｨ ｨｮ05ｨｨｨｰ ｨｺ02, 0609ｨｰｨ 00ｨｰ0907 ｨｪ ｨｪ04ｨｬ ｨｨ0504 ｨ ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨ02 ｨｺｨ ｨｨｨｪ04, Fat ｨｨ Dachso - us, ｨｨ ｨｰ06ｨｺｨ ｨｨｨｪ Flamingo ｨｨ0008ｨ 06ｨｰ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪｨｮ ｨｹ 09 ｨｨｨｪｨｨ02ｨｨｨ 02ｨｨｨｨ ｨｨ 08ｨ ｨｰ08ｨ ｨｪ02ｨｪｨｨｨｨ 09ｨｨ00ｨｪｨ [24, 64, 88, 91]. 07 ｨｬ0502ｨｺ0607ｨｨｨｰｨ 06ｨｴｨｨ ｨｬ Flamingo, Celsr1, ｨｰｨ ｨｺ 0302 ｨｪ02 06ｨ ｨｨｨｬ ｨ ﾂｨｨ 09ｨｨ00 ｨｪｨ ｨｮ05ｨｨｨｰ ｨｺ02 [15] ｨｨ 01ｨｨ ｨｬ06 ｨｬｨｮ, ｨｬ ｨｺｨｮ 0504, 06ｨ ﾂｨｨ 09ｨ 06 ｨｴｨｨ ｨｪ02 08ｨ 05ｨｹ ｨｪｨｮ06 ｨｬ0203 ｨｺ 0502 ｨｰ06 ﾂ ｨｪｨｮ06 ｨ ｨｨ06, ｨｨ00 08ｨ 06ｨｰ 09ｨｮ ｨｴ02 09ｨｰ ｨｪ ｨｪｨｮ ｨｹ ｨ ﾂ02 09ｨｨ00 ｨｪｨ ｨｨ ｨｨ ｨｬ ｨｪ ｨ ｨｪｨ ｨｰｨｨ ｨ 00ｨ 02ｨｰ 0907, ﾂｨｰ06 ｨｬｨｪ06 00ｨｨ02 09ｨｨ00 ｨｪｨ 05ｨｹ ｨｪ ｨｮ ｨｰｨｨ 0904ｨ ｨｨ - ｨｬ ｨｦ 09ｨｰ 09ｨｮ 06ｨｰ 0708ｨｨ ｨｮ ｨｨｨｨ ｨｮ05ｨｨｨｰ ｨｺ02 [48] ｨｰ 0902ｨｰ ｨｪｨ ｨｰ0607ｨｴｨｨ02 ｨｪｨ 0708ｨ ｨｴｨｨ02 09ｨｨ00ｨｪｨ 0504, ｨｺ06ｨｰ ｨｬ06-00ｨｮｨｰ ｨｰ06 07ｨｰｨｹ ｨｺｨ ｨｺ ｨｨ04 ｨｬ ｨｪ0609, ｨｰｨ ｨｺ ｨｨ ｨ 0205 ｨｺ0609, 06ｨ ﾂｨｨ - 09ｨ 06 ｨｴｨｨ01 ｨｬ0203 ｨｺ 0502 ｨｰ06 ﾂ ｨｪｨｮ06 ｨ ｨｨ06, 09ｨｰ ｨｪ ｨｺ06ｨｬ ｨｺ ｨ ｨｰｨｨ ｨ 06ｨｰ 0907 ｨ 09ｨｨｨｬ ｨｬ02ｨｰ 08ｨｨ ﾂ ｨｪ ｨｹ ｨｬ02 01ｨｨ 06-05ｨ ｨｰ0208ｨ 05ｨｹｨｪ06ｨｦ 0609ｨｨ ｨｮ05ｨｨｨｰｨｺｨｨ. 0308ｨｨ080601ｨ ｨｰ0607ｨｴｨｨ01 ｨｪｨ ｨ ｨｴｨｨ01 09ｨｨ00ｨｪｨ ｨｰｨ 02ｨｰ0907 ｨｪ020709ｨｪ06ｨｦ ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ06 Wnt-, Hh-, BMPs-, FGFs-, Fat-Dac h so us 0904ｨ ｨｨ ｨｬ ｨｦ 09ｨｰ 09ｨｨ07 ｨｬ06 00ｨｮｨｰ 04ｨ ｨｺ05ｨ ｨ ｨｰｨｹ ｨｨｨｪｨｨ 02ｨｨ ｨ 05ｨｹ ｨｪｨｮ ｨｪ0609ｨｰｨｹ 09ｨｰ ｨｪ ｨｺ06ｨｬ ｨｺ ｨ 00ｨ 02ｨｰ 0907, ﾂｨｰ06 ｨ ｨ - 04ｨ 05ｨｹ ｨｪ0402 ｨｰ02 05ｨｹ 02ｨ ｨｺｨ ｨｺ ｨ ｨｪｨｨ 04ｨ 02ｨｨ 06ｨｪ ｨｪ ｨｪ ｨｰ 0804 ｨｬｨｨｨｺ 0806 ｨｰ08ｨｮ - ｨ 06 ﾂ02ｨｺ 09ｨｰ ｨｨ 05ｨｨｨｦ ｨｬ06 00ｨｮｨｰ ｨｮ ﾂｨ 09ｨｰ ｨ ｨｰｨｹ ｨｰｨｨ ｨｺ02 09ｨｰ ｨｪ ｨｺ06ｨｬ ｨｺ ｨｨ/ｨｨ05ｨｨ ｨ ｨｰｨｹ ｨｨ ｨ ｨｪ ｨｪ ｨｰ ｨｪ ｨｺ06ｨｬ ｨｺ ｨｰ ｨｨ 05ｨｨ 07 ｨｬｨｨ, ﾂｨｰ06ｨ 04 ｨｺ ｨｨｨｪｨｨ080609ｨ ｨｰｨｹ ｨｨ01 ｨｮｨｪｨｨ000608ｨｬｨｪｨｮ ｨｨ02ｨｪｨｰｨ 02ｨｨ ｨｬ ｨ ｨｪ ｨｰｨｨ. ISSN
6 ﾁ ｨｮ 02ｨｰ 06ｨｰ ｨｬ02 ｨｰｨｨｨｰｨｹ, ﾂｨｰ ｨｨ ｨ ｨｪ ｨｪ04 ｨｬｨｨ 06ｨｺｨ ｨ 06ｨｰ ｨｪ02 ｨｰ06 05ｨｹ ｨｺ ｨｺ ｨｺ0502ｨｰ ｨｺｨｨ, ｨｪ06 ｨｨ ｨｨ 09ｨ 06 ｨｴｨｨ02 [44] ｨ ｨｰ02 05ｨｹ ｨｪ06, 06ｨ ｨｴｨｨ02 09ｨｨ00 ｨｪｨ ｨｨ 04ｨｮ 06ｨｰ ｨｰｨｨ ｨｺ0502 ｨｰ06ｨｺ 09 ｨｬ02 01ｨｨ 06 05ｨ ｨｰ02 08ｨ 05ｨｹ ｨｪ06ｨｬ ｨｪｨ 0708ｨ ｨｪｨｨｨｨ. 0202ｨｰ0208ｨｬｨｨｨｪｨ 02ｨｨ ｨｰ0208 ｨｬｨｨ ｨｪｨ 02ｨｨ02ｨｦ ｨ 04ｨｮ ｨｬ02 09ｨ 02ｨｰ ｨ 06-08ｨ ｨｺ0502ｨｰ ｨｺｨ ｨｬｨｨ ｨｪ ｨｪ ｨｮ ｨｰｨｨ 08ｨ 04 09ｨｨ ｨｰｨｨ07 ｨｨ04 ｨｬｨｪ06 00ｨｨ01 ｨ 05ｨｹ ｨｰ0208 ｨｪｨ ｨｰｨｨ09 ｨｪ ｨｰ0208 ｨｬｨｨ ｨｪｨ 02ｨｨｨｨ ｨｬｨｪ ｨｰｨ 07 ｨｪ04ｨｦ, ｨｬ ｨｰ 04ｨ ｨｰ08ｨ 00ｨｨ 09ｨ ｨｰｨｹ ｨｺｨ ｨｺ ｨｨ 06 ｨｪ04 ( ｨｨ 06 ｨｪｨ 05ｨｨ 04ｨ - 02ｨｨ07), ｨｰｨ ｨｺ ｨｨ 06ｨｰ ｨｹ ｨｪｨｮ06 ｨｺ0502ｨｰ ｨｺｨｮ (ｨｺ0502 ｨｰ06 ﾂ ｨｪｨ ｨｨ 00ｨｨ ｨｺｨ - 02ｨｨ07). 0308ｨｨ ｨｨ06ｨｪｨ 05ｨｨ04ｨ 02ｨｨｨｨ ｨｺ0502ｨｰｨｺｨｨ 02ｨｴ ｨ ｨｪ0706ｨｰ ｨ ｨｪ0609ｨｰｨｹ ｨｺ 08ｨ 0409ｨｨｨｰｨｨ ｨｬｨｪ0600ｨｨ01 ｨｪｨ 0708ｨ ｨｪｨｨ0701, ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ 0904ｨ ｨｨ08ｨ 02ｨｰ ｨｺ06ｨｪ ﾂｨ ｨｰ0205ｨｹｨｪ ｨｪｨ ｨｨ ｨｬ0603 ｨｪ ｨｮ 0102ｨ ｨｨ05ｨｨ ｨ ｨｬｨｬ 08ｨ 04 09ｨｨ ｨｰｨｨ ｨｪ ｨ, ｨｺｨ ｨｺ 0708ｨ 09ｨｨ 0506, ｨ ｨｰ ｨｬ ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨ 01ｨｨ02ｨｪｨｰ04, ｨｴｨｨ ｨｨ00ｨｨ ﾂ0209ｨｺｨｨ02 ｨｪｨ ｨ ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨｨ ｨｰ0208 ｨｬｨｨ ｨｪｨ ｨｪｨｰ, ｨｪ ｨｰ , ｨｺｨ ｨｺ 0708ｨ 09ｨｨ0506, ｨｨｨｰ 01ｨｨ ｨｪ02ｨｨｨ 05ｨｹｨｪｨ 07 05ｨｺ ｨｨ ｨｨ 00ｨｨ ﾂ02 09ｨｺ ｨｰ0208 ｨｬｨｨ ｨｪｨｨ 08ｨｮ 06 ｨｴ ｨｪｨ ｨｮ 05ｨｹ ｨｰｨ ｨｰ02 ｨｨ05ｨｨ ｨｰ0208 ｨｬｨｨ ｨｪｨ 05ｨｹ ｨｪ ｨ 09ｨｨｨｬ ｨｬ02ｨｰ 08ｨｨ ﾂ ｨｪ ｨｪｨｨ07 ｨｺ0502ｨｰ ｨｺｨｨ, ｨｨ05ｨｨ ｨ 05ｨ ｨｰ0208ｨ 05ｨｹｨｪ ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ ｨｨ 09ｨ ｨｪ ｨｪ ｨｨ00 ｨｪｨ 05ｨｹ ｨｪ ｨｨ 09 ｨｰ02 ｨｬ ｨｪ0609, ｨ - 06 ｨｴｨｨ02 ｨｬ ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨｨ ｨ 01ｨｨ 02ｨｪ ｨｰ04 09 ｨｮ05ｨｨｨｰ ｨｺ02, ｨｨ ｨｹ - 04ｨｮ 02 ｨｬ ｨｨ , 09ｨｺ , ｨ ｨｰ ｨｰｨ ｨｺ ｨｪ ｨ 0102ｨｰ0208ｨｬｨｨｨｪｨ 02ｨｨｨｨ 09ｨｮ0102ｨ ｨｨ ｨｬｨｨ080609ｨ ｨｪｨｨ07 07ｨ ｨｰｨｰ0208ｨｪｨ 08ｨ 04 ｨｪ0401 ｨｰｨｨ ｨｺ0502 ｨｰ06ｨｺ ｨｺ0608 ｨｰｨｨ ｨ ｨｪｨ ｨｹ 05ｨｰｨｨ ｨ 01ｨｨ 02ｨｪ ｨｰ0609, ｨｨ 01ｨｨ ｨｬ06 ｨｬｨｮ, 0609ｨｮ ｨｴ02 09ｨｰ ｨｰ0907 ｨｨ 08ｨ 01ｨｨ ｨｺｨ 05ｨｹ - ｨｪｨ 07 ｨｬ ｨｺｨｮ ｨｪｨ ｨｰ0806ｨｦ ｨｺｨ ｨｰｨｨ 07ｨ ｨｨ ｨｬ ｨｨｨｨ ｨｺ ｨｰ06ｨｺ, ｨｰｨ ｨｴｨｨ01 ｨｺ0608ｨｰｨｨ ｨ ｨｪ ｨｨ 06ｨ ﾂｨｨ09ｨ 02ｨｰ0907 ｨｨ01 09ｨｰ ｨｪ ｨｪ ｨ ｨｪｨｨ02 09 ｨｬ02 01ｨｨ06-05ｨ ｨｰ02 08ｨ 05ｨｹ - ｨｪ06ｨｬ ｨｪｨ 0708ｨ ｨｪｨｨｨｨ [99] ｨｰ ｨｪ06, ﾂｨｰ ｨ ﾂｨ 09ｨｨ00 ｨｪｨ ｨｬ ｨｪ0609, 0802 ｨｰｨｨ ｨｪ ｨｦ ｨｺｨｨ ｨｰ04 ｨｪ02 06ｨ ｨｨ ｨｬｨ ｨ 04-09ｨｨ ｨｰｨｨ ｨ ｨｪｨ ｨｰｨｨ ｨｺｨｨ ｨ ｨｪｨｨ ｨｰｨｨ ｨｪ ｨｰ ｨｺｨｮ 05ｨｹ ｨｰｨｮ 08ｨ 01 05ｨｬ ｨ 08ｨｨ 06 ｨｪｨ 05ｨｹ ｨｪ0401 ｨｮ05ｨｨ ｨｰ06ｨｺ ｨ ｨ - ｨｬ02ｨｰ ｨｪ ｨｪｨｨ 0302 ｨｪｨｨ02 ｨｺ06 05ｨｨ ﾂ02 09ｨｰ 09ｨ ｨｺ ｨｺ0502 ｨｰ06ｨｺ ｨｨ ｨｪｨ 08ｨｮ - 03ｨ ｨ 04 09ｨｨ ｨｰｨｨ ｨ ｨｪｨ ｨｰｨｨ. 01ｨ 09ｨｰｨ 01ｨｨｨｨ ｨｮ ｨｬ ｨｦ ｨｪｨ ﾂｨｨ ｨｪｨ 02ｨｰ ｨｨ 06 ｨｪｨ 05ｨｨ 04ｨ - 02ｨｨ07 09ｨｰ02 ｨｪ06ｨｺ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ. 0102ｨｪ oto co nin [105] ｨｨ 00ｨｨ - ﾂ02 09ｨｺｨｨ 05ｨｺ ｨｨ 08ｨｮ 02ｨｰ ｨｪ02ｨｦ 09ｨｰ02ｨｪ ｨｺ02 ｨｺｨ ｨｪｨ 05ｨ, ｨｰ ｨ ｨｺｨ ｨｺ 05ｨｺ ｨｨ07 ｨｪ02 ｨｺ06 ｨｰ ｨｮ 00ｨｨ ｨｪ0609, 09ｨｺ0506 ﾂｨ 07 Isl1 ｨｨ Sox2, ｨ ｨｪｨｨ ﾂ02 ｨｪｨ 01ｨｪ06ｨｬ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｪｨ 05ｨｨ ｨｪｨｨ07 Sox ｨｨ 02ｨｨｨｰ ｨｪ0401 ｨｬ ｨｦ ｪ light co at and cir c ling (Lcc) Lcc/Lcc ｨｪ ｨ ｨｪｨ 0102 ｨｰ0208 ｨｬｨｨ ｨｪｨｨ ｨ ｨｰｨｹ ｨｪ ｨｪ04ｨｦ ｨｨ 06ｨｪ, ｨｨ ｨｺｨ ｨｺ ｨｮ 05ｨｹ ｨｰｨ ｨｰ ｨｪ ｨｪｨｨ ｨｺｨ 06ｨｰ ｨｪｨｨ ｨｺ , ｨｪｨｨ ｨｨ 09ｨ 06 ｨｴｨｨ02 ｨｺ0502ｨｰ ｨｺｨｨ. 0208ｨｮ 00ｨ 07 ｨｬｨｮ ｨｰｨ ｨｪ ｨｰ ｨｪｨ 07 05ｨｨ ｨｪｨｨ07 ｨｬ ｨｦ yel low sub ma ri ne (Ysb) Ysb/Ysb 06ｨ ｨｪｨ 08ｨｮ 03ｨｨ 09ｨ 02ｨｰ ｨ ｨｪ06 ｨｬｨ 05ｨｹ ｨｪ ｨ 04 09ｨｨ ｨｰｨｨ02 05ｨｰ ｨｨ 06 ｨｪｨ ｨ ｨｪｨｨ ｨ ｨｪ - ｨｪ04 ｨｬｨｨ ｨｨ ｨｪ02 ｨｬｨｪ06 00ｨｨ ｨｬｨｨ ｨｺ ｨｬｨｨ ｨｺ0502ｨｰ ｨｺｨ ｨｬｨｨ ｨ - ｨｰ0205ｨｹ ｨｪ06, 0002ｨｪ Sox2 06ｨｰ 0902 ﾂｨ 02ｨｰ 04ｨ ｨｨ 06 ｨｪｨ 05ｨｨ 04ｨ 02ｨｨ06 09ｨｪｨ ﾂｨ 05ｨ ｨ ｨ 04ｨｨ ｨｪ06ｨｦ 0705ｨ 09 ｨｰｨｨｨｪ ｨｺｨｨ, ｨ 04ｨ ｨｰ02ｨｬ ｨｨ ｨｪ ｨｪ ｨｨ 06 - ｨｪｨ ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨｬ02 ｨｰ , ｨｪ ｨｪ04ｨｦ ｨｨ 06ｨｪ 01ｨ 08ｨ ｨｺ ｨｰ02-08ｨｨ 04ｨｮ 02ｨｰ ｨｺ ｨｨ02ｨｦ 0002 ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨｨ01 ｨｬｨ 08 ｨｺ , ｨｰｨ ｨｺｨｨ01, ｨｺｨ ｨｺ Jag ged1 [8, 52] ｨｨ Ser ra te1 (Ser1) [2], 05ｨｨ 00ｨ ｨｪ ｨｨ00 ｨｪｨ 05ｨｹ ｨｪ ｨｮ ｨｰｨｨ Notch, ｨ ｨｰｨ ｨｺ 0302 Bmp4 [2, 98] ｨｰ02ｨｪ - 02ｨｨ ｨ 05ｨｹ ｨｪｨ ｨｹ ｨｬ ｨｮ ｨ ﾂ02ｨｦ 09ｨｨ00 ｨｪｨ Sox2 ｨｨ Notch 06ｨ ｨｪｨ 08ｨｮ 03ｨｨ 09ｨ 02ｨｰ ｨｨ ｨｪｨ ｨ ｨｪｨｨｨｨ, ﾂｨｰ06 05ｨｺ ｨｨｨｨ07 Sox2 06ｨｰ 09ｨｮｨｰ 09ｨｰ 09ｨｮ 02ｨｰ ｨｮ ｨｮ ｨｪ0401 Jag ged1-ｨｬｨｮ ｨｰｨ ｨｪ ｨｰ0609 ｨｨ ｨｨｨｪ 00ｨｨ ｨ ｨｨ ｨ ｨｪｨｨ07 Notch [18, 52]. 01ｨ 09ｨｰｨ 01ｨｨｨｨ E13.5-E ｨｪ090608ｨｪ06ｨｬ ｨｨ06ｨｪ ｨｰ ｨｮｨ ｨｨ06ｨｪ04. 01ｨ 05ｨｰ06ｨｦ 09ｨｰｨ 01ｨｨｨｨ 08ｨ 0409ｨｨｨｰｨｨ07 ｨ 0605ｨｹ ｨｪｨ ﾂ02ｨｪｨｨ02 ｨｨｨｬ0202ｨｰ ｨ ﾂｨ 09ｨｨ00ｨｪｨ fibroblast growth factors (FGFs) ｨ 04 05ｨｨ ﾂ ｨｪ0401 Fgfs 0002 ｨｪｨ ｨｨ 4 FGF ｨｰ06 08ｨ Fgfr1-4 ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪ04 ｨｮ ｨｬ0403ｨｨ ｨｨ ﾂ ｨｺｨ. 0306ｨｬｨｨｨｬ06 ｨｮ ﾂｨ 09ｨｰｨｨ ｨ ｨｪｨｪｨｨ01 ｨｨｨｪ01ｨｮｨｺｨｰｨｨ09ｨｪ ｨ 04ｨｰｨｨ ｨｮ ｨｮ040408ｨｹｨｺｨ [1] 05ｨｰ ｨｬ02ｨｦ09ｨｰ ｨｪ0609 ｨｮ ﾂｨ 09ｨｰ09ｨｮ02ｨｰ ｨｰｨ ｨｺ ｨ ｨｰ0208ｨｬｨｨｨｪｨ 02ｨｨｨｨ ｨｨ 01ｨｨ ｨｪ02ｨｨ080609ｨｺｨｨ ｨｺ0502ｨｰ06ｨｺ 09ｨｪｨｮｨｰ0802ｨｪｨｪ ｨｮ01ｨ. 08ｨ ｨｺｨｰ FGF10 ｨｨ FGF ｨｰｨｮ07ｨ 06ｨｰ 09 ｨｺｨ ﾂ0209ｨｰ ｨｨ00ｨ ｨｪ ｨｰ06 08ｨ FGFR2. FGF16 ｨｰｨ ｨｺ 0302 ｨｬ ｨｰ ｨ 04ｨｰｨｹ 09ｨ 03 ｨｪ04ｨｬ 05ｨｨ00ｨ ｨｪ0106ｨｬ FGFR2 [35]. FGF8 0102ｨｦ09ｨｰ09ｨｮ02ｨｰ ｨｰ0906ｨｬ FGFR3, ｨ FGF9 ｨｨ FGF20, 09ｨｺ , ｨｰ 0906ｨｬ ｨｰ0608ｨ FGFR ｨｰｨ ｨｪ ｨｪ04 07ｨ ｨｰｨｰ0208ｨｪ04 05ｨｺ ｨｨｨｨ ﾂ02ｨｰ ｨｪ ｨｰ FGFR [38]. 01ｨ 09ｨｰｨ 01ｨｨｨｨ E13.5, ｨｺ060001ｨ ｨｨ ｨｨｨｰ ｨｨ00ｨｨｨｺｨ 02ｨｨ ｨｰ0902ｨｪｨｪｨｨｨｺ ｨｺ ｨｨ ｨｨ09ｨ 06ｨｴｨｨ01 ｨｺ0502ｨｰ06ｨｺ ｨｮｨｬ07ｨｰｨｨ09ｨｪ06ｨｬ ｨｺ0608ｨｰｨｨ020906ｨｬ ｨ ｨｪ02, ｨｺｨ ｨｪｨ 05 ｨｮ05ｨｨｨｰｨｺｨｨ 05ｨｺ ｨｨ08ｨｮ02ｨｰ 0002ｨｪ ｨｰ Fgfr1 ｨｨ Fgfr2, ｨｰ ｨ ｨｺｨ ｨｺ 0002 ｨｪ04 Fgfr3 ｨｨ Fgfr4 ｨｪ02 05ｨｺ ｨｨ08ｨｮ06ｨｰ ｨｨｨｰ0205ｨｨｨｨ [38]. 06ｨｺ ｨｨ ｨｪｨ Fgfr1 09 ｨ ｨ 04ｨｨ050708ｨｪ06ｨｦ 0705ｨ 09ｨｰｨｨｨｪｨｺ02 ｨｨ0008ｨ 02ｨｰ ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺｨｮ ｨｹ ｨｨ - 00ｨｨｨｺｨ 02ｨｨｨｨ ｨｪ090608ｨｪ ｨｬ02ｨｪｨ [36, 75]. 06ｨｺ ｨｨ ｨｪｨ Fgfr ｨ ｨｪｨｨ ﾂｨｨ09ｨ 02ｨｰ0907 ｨｪ020902ｨｪ090608ｨｪ04ｨｬｨｨ ｨｨ06ｨｪｨ - ｨｬｨｨ ｨｺｨ ｨｪｨ 05ｨ ｨｮ05ｨｨｨｰｨｺｨｨ [38] ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｺｨ ｨｺ FGFR1, ｨｰｨ ｨｺ ｨｨ FGF20 ｨｨ00 08ｨ 06ｨｰ ｨｺ ﾂ0209ｨｮ ｨｹ ｨｨ06ｨｪｨ 05ｨｨ04ｨ 02ｨｨｨｨ ｨｪ090608ｨｪ ｨｨ06ｨｪｨ [36, 75]. 06ｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ02 FGF20 ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ E ｨ 02ｨｰ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ ｨｺ ｨｨ ｨｨ 09ｨ 06 ｨｴｨｨ01 ｨｺ0502 ｨｰ06ｨｺ ｨｰ06 ﾂ ｨｪ06 ｨｰｨ ｨｺ 0302, ｨｺｨ ｨｺ 0708ｨｨ ｨｨｨｨ 0002 ｨｪｨ Fgfr1 [36]. 06ｨｰ ｨ ｨｪ ｨｺｨｨｨｬ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02ｨｬ 05ｨｺ ｨｨｨｨ 0002 ｨｪ0609 Pea3 ｨｨ Erm ｨｨ 0706ｨｰ020802ｨｦ 05ｨｺ ｨｨｨｨ 0002ｨｪｨ Math ｨｪ IGF-1 ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｰ ｨｮ ｨｬ040302ｨｦ 0002ｨｪ Fgf15, 0608ｨｰ ﾂ ﾂ0209ｨｺ ｨｨ ｨｺｨｮ08ｨｨｨｪ ｨｪｨ Fgf19, ｨｺ06ｨｰ060804ｨｦ 06ｨ ｨｪｨ 08ｨｮ03ｨｨ09ｨ - 02ｨｰ 07ｨ ｨｰｨｰ0208ｨｪ 05ｨｺ ｨｨｨｨ, ｨｰ ｨ 06ｨｴｨｨｨｦ ｨｺ05ｨ ｨｨ00ｨｨｨｺｨ 02ｨｨ06 09ｨｮ0102ｨ ｨｺ0502ｨｰ06ｨｺ ｨｪ090608ｨｪ06ｨｬ 0507ｨｨｨｰ0205ｨｨｨｨ [86]. 06ｨｰｨ 09ｨｨ09ｨｰ02ｨｬｨ 0002ｨｪ0609 ｨｮ ﾂｨ 09ｨｰ09ｨｮ02ｨｰ ｨｨ ｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ 09ｨｮ0102ｨ 06ｨｰ ｨｹ ｨｪ0401 ｨｰｨｨ ｨｺ0502 ｨｰ06ｨｺ. 06ｨ ｨｺ, 09ｨｪｨ ﾂｨ 05ｨ ｨｮｨｬ 07 ｨｰｨｨ09 ｨｪ ｨｰ0605ｨ ﾂｨ ｨｰ0402 ｨｺ0502ｨｰ ｨｺｨｨ, ｨｨ 0102ｨｦ ｨｰ ｨｺｨｨ02 ｨｺ0502ｨｰ ｨｺｨｨ 05ｨｺ ｨｨ 08ｨｮ 06ｨｰ ｨｺｨｨ02 ｨｮ ｨｪｨｨ Fgfr1 ｨｨ Fgfr3 [38]. 01ｨ 09ｨｰｨ 01ｨｨｨｨ E ｨｪｨｮｨｰ 0802ｨｪ ｨｪｨｨ ｨｺ ｨｺ0502ｨｰ ｨｺｨｨ 05ｨｺ ｨｨ 08ｨｮ 06ｨｰ Math-GFP ｨｨ Fgf8, ｨ Fgfr3 05ｨｺ ｨｨ08ｨｮ06ｨｰ ｨｪｨｨｨｬｨｨ 09ｨｰ0605ｨ ﾂｨ ｨｰ04 ｨｬｨｨ ｨｺ0502ｨｰ ｨｺｨ ｨｬｨｨ [37, 42, 78] ｨｨ ｨｪｨ Fgfr ｨ 02ｨｰ ｨｮ ｨｬ ｨｦ ｨｨ04 ｨ 04 ｨｰ06 ﾂ ｨｪｨｮ ｨｮｨｺ 02ｨｨ ｨｨ ｨｨ 09ｨ 06 ｨｴｨｨ01 ｨｺ0502 ｨｰ06ｨｺ 0202ｨｦ ｨｰ ｨ 09 ｨ 07ｨｨ ｨｺｨ 05ｨｹ ｨｪ ｨｮ01 ｨｰ ｨｰ0701 ｨｮ05ｨｨｨｰ ｨｺｨｨ ｨ ｨｰ02 05ｨｹ ｨｪ06, 0102ｨｦ 09ｨｰ 09ｨｨ ｨｰ02 05ｨｹ ｨｪ06, 0002ｨｪ Fgfr3 06ｨｰ ﾂｨ 02ｨｰ 04ｨ 0102 ｨｰ0208 ｨｬｨｨ ｨｪｨ 02ｨｨ06 09ｨｰ0605ｨ ﾂｨ ｨｰ0401 ｨｺ0502 ｨｰ06ｨｺ. 01ｨ 05ｨｰ06ｨｦ ｨｰｨ 01ｨｨｨｨ 08ｨ 0409ｨｨｨｰｨｨ07 ｨｮ0706ｨｬ07ｨｪｨｮｨｰ04ｨｦ ｨｬ0201ｨｨ ｨ ｨｰ02 08ｨ 05ｨｹ ｨｪ04ｨｦ 0008ｨ 01ｨｨ 02ｨｪｨｰ ｨ 0205 ｨｺｨ Bmp ｨｰ ｨｪｨｨｨｺ ｨｪ ｨｪｨｨ02 ｨｺ0502 ｨｰ06ｨｺ 0102ｨｪ 0402 ｨｪｨ ｨｨ 0805ｨ ｨｮ 01ｨｨ ｨｮ 09ｨ ｨｺ0608 ｨｰｨｨ 02 09ｨ ｨ - ｨｪｨ [5] ｨｪ Hey2-04ｨ 09ｨｨ 09ｨｨ ｨｬ04ｨｦ ｨｬ02 01ｨ ｨｪｨｨ04ｨｬ 0102 ｨｰ0208 ｨｬｨｨ ｨｪｨ - 02ｨｨｨｨ 09ｨｰ0605ｨ ﾂｨ ｨｰ0401 ｨｺ0502 ｨｰ06ｨｺ [21]. 02ｨ ｨｮｨ ｨｨ 06 ｨｪ02 ｨｨ ｨｺ ｨｨ ｨｨ09ｨ 06ｨｴｨｨ01 ｨｺ0502ｨｰ06ｨｺ, 05ｨｺ ｨｨ08ｨｮ06ｨｴｨｨ ｨｪ04 SOX2 ｨｨ SOX9, ｨｨ ｨｨｨｰ ｨｨ00ｨｨｨｺｨ 02ｨｨ ｨｺ ｨｨ ｨｨ 09ｨ 06 ｨｴｨｨ01 ｨｺ0502 ｨｰ06ｨｺ, ｨ 05ｨ ｨ 0807 ｨｨ09 ﾂ0204 ｨｪ
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Est_na_perelome.pdf
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tom2.p65
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4_2009.p65
1300030506010608 0402050506070508020102 01070008010606080401020102 010807 ﾁ01020102 0802010208 2009 4 (57) 0906050502ｨｰ02ｨｪｨｹ 060401ｨ 02ｨｰ0907 09 1995 00. 0004010601ｨｨｨｰ 4 08ｨ 04ｨ 09 000601 13000209ｨｰｨｪｨｨｨｺ
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028265rs.p65
13WS 431 TX Cｨｰｨｨ08ｨ 05ｨｹｨｪｨ 07 ｨｬｨ 03ｨｨｨｪｨ 04ｨｮｨｺ0609060109ｨｰ0906 0706 ｨｮ09ｨｰｨ ｨｪ0609ｨｺ02 ｨｨ 05ｨｺ090705ｨｮｨ ｨｰｨ 02ｨｨｨｨ Washing machine Instructions for installation and use 040501ｨｪ000709ｨｦ07 090705 ﾂｨｴｨｪ
Verstka_#14.FH10
133 (14)/2004 ｨ 07080205ｨｹ 05020108 02030902 0601020408 0507060801060108 0201020105 050802040906 06 01080203040204 1304ｨｮ08ｨｪｨ 05 ｰ0608020902010608 ｨｨ 0304080002 ｱ - ｨｪ02ｨｺ06ｨｬｨｬ0208 ﾂ0209ｨｺ0602 ｨｪ02000609ｨｮ01ｨ
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VP:CorelVentura 7.0
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R03_LAVALOGIC_1820_LCD_5kg_BT_db.bk
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BEJ pmd
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R03_OKO-LAVAMAT_LAVALOGIC_1810_LCD.bk
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КАФЕДРА ТЕОРИИ ВЕРОЯТНОСТЕЙ
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Libretto_New_RS
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OKO-LAVAMAT_88840_advanced.bk
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2_2004_
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для типогр-часть1.p65
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soderzhanie-05.indd
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GIS_Nov_Kar
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Untitled-30
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059_1
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MP-14.pmd
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TIT.p65
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Симпозиум-2007-пробный p65
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World Bank Document
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Mova_12.p65
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Китай - надвигается война?
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Ãëÿíåö.pm6
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Microsoft Word - Муравьев.doc
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772_a.p65
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Maket.pmd
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katalog.p65
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lamrim_2 (îðèãèíàë).pdf
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Ò_1.PM6
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r-01.p65
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25_rozdil.indd
1325 05ｨｰｨ ｨ ｨｨ05ｨｹｨｪｨ 07 09ｨｰ02ｨｪ06ｨｺｨ 0801ｨｨ07 Satya Reddy Atmakuri, MD, Michael H. Gollob, MD ｧﾚ Neal S. Kleiman, MD 0000030203010603 00 21 0902ｨｺ02 08ｨ 0907080609ｨｰ08ｨ ｨｪ02ｨｪｨｪ0609ｨｰｨｹ ｨｨ0302ｨｬｨｨ ﾂ0209ｨｺ06ｨｦ
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033722rs.p65
13M M ARGHERITA 05ｨｰｨｨ08ｨ 05ｨｹｨｪｨ 07 ｨｬｨ 03ｨｨｨｪｨ 09 09ｨｮ03ｨｺ06ｨｦ 06ｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ 0706 ｨｮ09ｨｰｨ ｨｪ0609ｨｺ02 ｨｨ ｨｨ09070605ｨｲ040609ｨ ｨｪｨｨ06 Washer-dryer Instructions for installation and use 13CIS GB 05ｨｰｨｨ08ｨ
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CH_0_RU.p65
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Оглавление.pmd
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RA2.qxd
1300ｨｨ01ｨ 02ｨｰｨｹ0907 04 0906 ﾂｨｪ07 1993 08. 012 (126) 0506ｨｰｨｨｨｦ 2004 0206ｨｬ060907 ﾂｨｪｨｨｨｦ ｨｪｨ ｨｮｨｺ060906-070607ｨｮ050708ｨｪｨｨｨｦ 03ｨｮ08ｨｪｨ 05 05070605ｨｹｨｪ02 09ｨｨ01ｨ ｨｪｨｪ07 04 0106T 040305 07ｨｺ08ｨ 07ｨｪｨｨ
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One Blood.p65
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RA11.qxd
1300ｨｨ01ｨ 02ｨｰｨｹ0907 04 0906 ﾂｨｪ07 1993 08. 0111 (135) 05ｨｨ09ｨｰ0607ｨ 01 2004 0206ｨｬ060907 ﾂｨｪｨｨｨｦ ｨｪｨ ｨｮｨｺ060906-070607ｨｮ050708ｨｪｨｨｨｦ 03ｨｮ08ｨｪｨ 05 05070605ｨｹｨｪ02 09ｨｨ01ｨ ｨｪｨｪ07 04 0106T 040305 07ｨｺ08ｨ
Fungi4.p65
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NO- 3 (2010)
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oblogka_№2(5)_2007_.cdr
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cee didelis
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Overshoot (R) (Lat 16 Jan).qxd
130802010300 0603090102070602030606 13OVERSHOOT The Ecological Basis of Revolutionary Change carrying capacity: cornucopian myth: drawdown: cargoism: overshoot: crash: maximum permanently supportable load.
rus-07-Minilap-text.qxp
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