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1 ｨ 0902ｨｪｨｺ ｨ ｨｺ ｨｨｨｪｨｰ06ｨｪ ｨｰ ｨｪｨｨ02 08ｨ 01ｨｨ ｨｨｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ ｨ ｨｺｨｮ05ｨｹｨｰ02ｨｰｨ 00ｨ 03ｨｨｨｪ00ｨｰ06ｨｪ09ｨｺ ｨｪｨｨ ｨｨｨｰ02ｨｰｨ, 0502ｨｪｨｰ 09ｨｮｨｨ09, ｧｱｧｰｧｩｧｪｧｴｧｲｧｰｧｯｧｯｧ ｧﾁ'ｧｿｧｮｧｪｧｳｧｳｧｪｧｰｧｯｧｯｧ ｧﾁ ｧｴｧｰｧｮｧｰｧ ｧｲｧ ｧｶｧｪｧﾁ'ｧ ｧｰｧｭｧｰｧ ｧｯｧｰｧ ｧｰ ｧｮｧｰｧｩｧ ｧ :'ｧｰｧｳｧｯｧｰｧ ｧｯｧｽｧｦ'ｧｱｧｲｧｪｧｯｧｸｧｪｧｱｧｽ ｧｪ'ｧｱｧｲｧｪｧｮｧｦｧｯｧｦｧｯｧｪｧｦ'ｧｵ'ｧｹｧｦｧｭｧｰｧ ｧｦｧｬｧ 2 06ｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｪ02ｨｦ080601ｨｨ08ｨｮ0800ｨｨｨｨ, 08ｨｨ ﾂ ｨ : ｨｨｨｰ0806ｨｪｨｪｨ 07 05ｨｬｨｨ0909ｨｨ06ｨｪｨｪｨ 07 ｨｰ06ｨｬ060008ｨ 00ｨｨ07, ｨｺ060806ｨｰｨｺ0603ｨｨ09ｨｮｨｴｨｨ02 ｨｨ0406ｨｰ060704, 08ｨ 01ｨｨ0600ｨ 08ｨｬ ｨ 08ｨ ｨｰ04, 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ 04, 00ｨｪｨｨｨｴｨ ｨｮ04ｨｨ0703, 00ｨｨ0302ｨｬｨｨ ﾂ0209ｨｺｨ ｨｮｨｰ02ｨｪｨｹ03, 0001ｨｨｨ 03ｨｨ ｨｬ ｨｨｨｰ0806ｨｪｨｪｨ 07 05ｨｬｨｨ0909ｨｨ06ｨｪｨｪｨ 07 ｨｰ06ｨｬ060008ｨ 00ｨｨ07 (030606) ｨｮ ﾂｨ 02ｨｰ ｨ 0605ｨｹ ｨｨ04ｨｪｨ ｨｪｨｨ02 09 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺ ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 ｨｺ060806ｨｰｨｺ0603ｨｨ09ｨｮｨｴｨｨ01 ｨｨ0406ｨｰ ｨｰ ｨｨｨｰｨｹ ｨｰ0608ｨｪ0402 ｨｨ ｨ ｨｪｨｨ07 ﾂ ｨｺ060806ｨｰｨｺｨｨ ｨｬ0203ｨｮｨｰｨｺｨｨ ｨｬ02ｨｪｨｨ ｨｨ ｨｨ ｨｹ040609ｨ ｨｰｨｹ 08ｨ 0405ｨｨ ﾂｨｪ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ ｨｰｨ ｨｰ ｨｮｨｪｨｨｨｺｨ 05ｨｹｨｪｨｮ ｨｬ0603ｨｪ0609ｨｰｨｹ ｨｪ02ｨｨｨｪ09ｨ 04ｨｨ09ｨｪ06ｨｦ ｨｺ0605ｨｨ ﾂ0209ｨｰ0902ｨｪｨｪ06ｨｦ ｨｪｨｺｨｨ ｨｬ ｨｦ 0002ｨｬ0601ｨｨｨｪｨ ｨｬｨｨｨｺｨｨ, 05ｨｪ ｨｰｨｨ ﾂ0209ｨｺ ｨ ｨｬ02ｨｪｨ ｨｬ060400ｨ, ｨ ｨｰｨ ｨｺ ｨｰ ｨｨ ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨｪ ｨｨ09ｨｰ02ｨｬ ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ 09ｨｰ090609ｨ 05ｨ ｨｪ09ｨｰ090609ｨ ｨｪｨｨ06 04ｨｪｨ ｨｪｨｨｨｦ 06 09ｨｰｨ 01ｨｨ ｨ 0409ｨｨｨｰｨｨ07 ｨｨ0302ｨｬｨｨｨｨ ｨｬ060400ｨ, ｨ ｨｰｨ ｨｺ ｨｨ05ｨ 0607ｨｨ09ｨ ｨｰｨｹ ｨｰｨ ｨｺｨｨ02 09ｨ 03ｨｪ ｨ ｨｰ0600ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨｪ06ｨｬ02ｨｪ04, ｨｺｨ ｨｺ 00ｨｪｨｨｨｴｨ ｨｮ04ｨｨ0703, 00ｨｨ0302ｨｬｨｨ ﾂ0209ｨｺｨ ｨｮｨｰ02ｨｪｨｹ03 ｨｨ 0001ｨｨｨ 03ｨｨ ｨｪ0600ｨｨ02 03ｨｨ04ｨｪ02ｨｪｨｪ06 09ｨ 03ｨｪ ｨｮｨｪｨｺ02ｨｨｨｨ ｨｪ ｨｬ060400ｨ ｨ 0405ｨｨ ｨｨ04ｨｮ ﾂ02ｨｪ ｨｨ 0706ｨｬ06ｨｴｨｨ ｨｨ ｨｹ040609ｨ ｨｪｨｨ02ｨｬ 08ｨ 0405ｨｨ ﾂｨｪ ｨｪ ﾂ0209ｨｺｨｨ01, 0109ｨｨ00ｨ ｨｰ0205ｨｹｨｪ0401 ｨｨ ｨｺ0600ｨｪｨｨｨｰｨｨ09ｨｪ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｪｨ 0008ｨｮ0406ｨｺ ｨｨｨｰ0806ｨｪｨｪｨ 07 05ｨｬｨｨ0909ｨｨ06ｨｪｨｪｨ 07 ｨｰ06ｨｬ060008ｨ 00ｨｨ07 (030606) ｨｰ ｨｺ ｨｺｨｰｨｨ09ｨｪ04ｨｬ, ｨｬｨｨｨｪｨｨｨｬｨ 05ｨｹｨｪ06 ｨｨｨｪ09ｨ 04ｨｨ09ｨｪ04ｨｬ ｨｬ02ｨｰ060106ｨｬ ｨｨ ｨ ｨｪｨｨ07, ｨｺ06ｨｰ060804ｨｦ 09 ｨｺｨ ｨｬ ｨｬ 0708ｨｨ06ｨ 0802ｨｰｨ 02ｨｰ ｨ 0605ｨｹ ｨ ｨｰ08ｨ ｨｪ02ｨｪｨｨ02 09 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺ02 (Costa D.C. et al., 1999; Doherty M.J., Marsden P.K., 2000) ｨｰ ｨｮ ﾂｨ ｨｰｨｹ ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨ07 ｨｨ 08ｨ 0909 ﾂｨｨｨｰ0409ｨ ｨｰｨｹ ｨｺ0605ｨｨ ﾂ0209ｨｰ0902ｨｪｨｪ ｨｺｨ 04ｨ ｨｰ0205ｨｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｪ ｨｬ060400ｨ, ｨｪ02 ｨｪｨ 08ｨｮ03ｨ 07 01ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨｦ09ｨｰ09 ｨｨ04ｨｮ ﾂｨ 02ｨｬ ｨ 08ｨ ｨ ｨｪｨｨｨｦ. 06ｨｰ06ｨｰ ｨｬ02ｨｰ ｨｨ0802 ｨｨ ｨｹ04ｨｮ06ｨｰ ｨｺｨ ｨｺ 09 05ｨｺ ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0401 ｨｨ ｨ ｨｪｨｨ ｨ 0405ｨｨ ﾂｨｪ ｨ 05ｨ 09ｨｰ0701 ｨｪ02ｨｦ0806ｨｪｨ ｨｮｨｺ, ｨｰｨ ｨｺ ｨｨ 09 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ ｨｪ ｨｨｨｨ, ｨｪ02ｨｦ080601ｨｨ08ｨｮ0800ｨｨｨｨ ｨｨ 0709ｨｨ01ｨｨｨ ｨｰ08ｨｨｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｪ ｨｬ060400ｨ 0706 ｨｬ ｨ 0409ｨｨｨｰｨｨ07, ｨ ｨｰｨ ｨｺ ｨ ｨｺ02ｨｨｨｦ ｨｪｨ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0402, 0109ｨｨ00ｨ ｨｰ0205ｨｹｨｪ0402, ｨｺ0600ｨｪｨｨｨｰｨｨ09ｨｪ0402 ｨｨ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨ ｨ 03ｨｨｨｰ0205ｨｨ ｨｬ02 ｨｰ060006, ｨｬ02ｨｰ0601 ｨｨ ｨｹ04ｨｮ06ｨｰ ｨｰｨ ｨｺ ｨｪｨｺｨｨ 07ｨ ｨｰ0600ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ01 08ｨ 0909ｨｰ0806ｨｦ09ｨｰ09, 06ｨ ｨｮ ｨｪｨｪ ｨ 0405ｨｨ ﾂｨｪ04ｨｬｨｨ 04ｨ ｨ ｨ ｨｪｨｨ07ｨｬｨｨ, ｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0502 ﾂ02ｨｪｨｨ07 ｨｰｨ ｨｺｨｨ01 04ｨ ｨ ｨ ｨｪｨｨｨｦ. ｧｰｧｳｧｯｧｰｧ ｧｯｧｽｧｦ'ｧｱｧｲｧｪｧｯｧｸｧｪｧｱｧｽ,'ｧｪｧｩｧｰｧｴｧｰｧｱｧｽ ｧｪ'ｧｲｧ ｧ ｧｪｧｰｧｶｧ ｧｲｧｮｧｱｧｲｧｦｧｱｧ ｧｲｧ ｧｴｧｽ'(ｧｲｧｶｧｱ) 0308ｨｨｨｪ02ｨｨ ｨｦ09ｨｰ09ｨｨ ｨｪ0609ｨ ｨｪ ｨｪｨ ｨｨ09ｨｰ08ｨ 02ｨｨｨｨ 07ｨ ｨｰ06ｨｪ0609, ｨｪｨｨｨｺｨ 06ｨｴ02ｨｦ ｨｮ05ｨｹｨｰｨ ｨｰ02 ｨ ｨｪｨｪｨｨ00ｨｨ050702ｨｨｨｨ 0708ｨｨ 09ｨｰ0605ｨｺｨｪ060902ｨｪｨｨｨｨ ｨｨｨｰ0806ｨｪｨ, ｨｨ0907ｨｮ09ｨｺｨ 02ｨｬ ｨｨ0406ｨｰ060706ｨｬ, ｨｺｨｰ0806ｨｪ06ｨｬ. 06ｨ ｨｺｨ ｨｨ09ｨｰ08ｨ 02ｨｨ07 06ｨ ﾂｨｨ09ｨ 02ｨｰ ｨ 0802ｨｪｨｪ04ｨｬｨｨ (08ｨ ｨｪｨｪ04ｨｬｨｨ 0108ｨｮ00 ｨｪｨ ｨｰｨｨ ｨｮ00ｨ ) 0102ｨｰ02ｨｺｨｰ0608ｨ ｨｬｨｨ, ｨｺｨ ｨｺ 0708ｨ 09ｨｨ0506, 06ｨ ｨｲ0201ｨｨｨｪ02ｨｪｨｪ04ｨｬｨｨ 09 ｨｺ0605ｨｹ ｨｨ. 06ｨｪ000608ｨｬｨ 02ｨｨ07, ｨｰｨｮ07ｨ 06ｨｴｨ 07 06ｨｰ ｨｺｨ ｨｦ 07ｨ ｨｰ02ｨｺｨｰ , ｨｨ ｨｹ04ｨｮ02ｨｰ ｨｺ06ｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨｨｦ 09 09ｨｨ0102 ｨｰ06ｨｬ060008ｨ 00ｨｨ- ﾂ0209ｨｺｨｨ (Ter-Pogossian M.M., 1992, 1997). 05ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ04ｨｦ ｨｺｨ ｨｪ ｨｰ06ｨｨｨｰ ｨｨ04 ｨｬｨｪ ｨｰ09ｨ 0102ｨｰ02ｨｺｨｰ (01ｨ ｨｰ ﾂｨｨｨｺ0609), ｨｪ0209ｨｮｨｴ02ｨｦ ﾂｨ 09ｨｰｨｨ (0002ｨｪｨｰ08ｨｨ), ｨ ｨｰｨ ｨｺ ｨｨ09ｨｰ02ｨｬ ｨｮ ﾂ02ｨｪｨｨ07 ｨｨ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ 09ｨｨ00ｨｪｨ ｨｰ02ｨｺｨｰ ｨ 08ｨ 04ｨｮ06ｨｰ ｨｨ0405ｨｮ ﾂｨ 02ｨｬ04ｨｦ 09ｨｨ00ｨｪｨ ｨｺｨｰ08ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｮｨｴｨ 07 ﾂｨ 09ｨｰｨｹ ｨｨ09ｨ 02ｨｰ 0102ｨｰ02ｨｺｨｰ ｨｨ ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｰ ｨｨ ｨ 09ｨｨ05ｨｹｨｪｨｮ ｨｨ02ｨｪｨｰｨ 02ｨｨ06. 02ｨ 08ｨ ｨ ｨ ｨｰ0409ｨ 06ｨｴｨｨ02 09ｨｨ09ｨｰ02ｨｬ ｨｮｨｴ0209ｨｰ ｨｰ 09ｨ 0608, 0108ｨ ｨｪ02ｨｪｨｨ02 ｨｨ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｮ ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ, ｨｨ09ｨｰ08ｨｨ08ｨｮ02ｨｬ06ｨｦ 0102ｨｰ02ｨｺｨｰ0608ｨ ｨｬｨｨ, 0802ｨｺ06ｨｪ09ｨｰ08ｨｮｨｺ02ｨｨ06 ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨｨｦ ｨｨ ｨｨ ｨｨ ｨｪｨｨ02 ｨｪｨ 01ｨｨ ｨｨｨｰ0806ｨｪｨｨ0907ｨｮ09ｨｺｨ 06ｨｴｨｨ02 ｨｨ0406ｨｰ060704, 0708ｨｨｨｬ02ｨｪ0702ｨｬ ｨｨ ｨ ｨｪｨｨ0701, ｨｨ ｨｰ ｨｬ06ｨｴｨｹ06 ｨｮ09ｨｺ0608ｨｨｨｰ ﾂｨ 09ｨｰｨｨ02 (ｨｺｨ ｨｺ 0708ｨ 09ｨｨ0506, ｨｬｨｨｨｪｨｨ-02ｨｨｨｺ0506ｨｰ0806ｨｪｨ ) ｨｮ ﾂ02ｨｪｨｨ07 ｨｨ0406ｨｰ ｨｰｨ ｨｰ 09 08ｨ 01ｨｨ0601ｨｨｨｬｨｨ ﾂ0209ｨｺｨｮ06 05ｨ ｨ 0608ｨ ｨｰ0608ｨｨ06, ｨｨｨｬ ｨｬ02ｨｰ07ｨｰ ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴ ｨｴ0209ｨｰ0906, ｨｺ06ｨｰ ｨ 05ｨｹｨｪ02ｨｦ0302ｨｬ ｨｨ ｨｹ04ｨｮ02ｨｰ ｨｨ ｨ ｨｪｨｨ07. 01ｨ ｨｨｨ 0605ｨｹ03ｨｨ ｨ 0502ｨｬ ｨｨ ｨｰ ｨｪｨｨｨｺｨ 06ｨｰ ｨｨ04-04ｨ ｨｪ0206ｨ ｨｨｨｬ0609ｨｰｨｨ ｨｨ ｨｹ040609ｨ ｨｪｨｨ07 ｨ 0409ｨｰ ｨｰ02ｨｺｨ 06ｨｴｨｨ01 01ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｺ02ｨｨｨｦ ｨｨ ｨ 0409ｨｰ0806ｨｦ 06 ﾂｨｨ09ｨｰｨｺｨｨ ｨｮ- ﾂｨ 02ｨｬ ｨｴ0209ｨｰ ｨ ｨ 09ｨｪ ｨｪｨｨ07 ﾂ ｨｺｨｮ ｨｰ09ｨｨ02 ｨｺ060806ｨｰｨｺ ｨｨ0601ｨ ｨｮ08ｨ 0907ｨ 01ｨ ｨ ｨｴ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ09ｨ ｨｨ0406ｨｰ , ｨｨ ｨｹ04ｨｮ06ｨｴｨｨ , 02ｨｨｨｺ0506ｨｰ0806ｨｪ ｨｨ 08ｨ 01ｨｨ0601ｨｨｨｬｨｨ ﾂ0209ｨｺｨ 07 05ｨ ｨ 0608ｨ ｨｰ0608ｨｨ ｨｪ04 ｨｪｨ ｨｨｨｰｨｹ ｨｪ ｨｰ0902ｨｪｨｪ06ｨｦ ｨ 05ｨｨ040609ｨｰｨｨ 06ｨｰ ｨｨｨｰ0806ｨｪｨｪ ｨｰ06ｨｬ060008ｨ 00ｨ, ｨ ｨｪ 09ｨｨｨｪｨｰ0204ｨｨ080609ｨ ｨｰｨｹ ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ ｨ ｨｰ ｨｺｨｨ ﾁ ﾁ ｨC 01 2 (28) ｨC III/IV

2 08ｨ ｨｺ 0708ｨ 09ｨｨ0506, ｨｨｨｬ02ｨｪ0706ｨｰ ｨｨ0406ｨｰ ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ ｨｬ02ｨｪｨｰ0609, ｨｰｨ ｨｪｨｪ ｨｨ ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ01 09ｨｨ09ｨｰ02ｨｬｨ ｨ 0605ｨｹ0306ｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ0902. ﾁｨ ｨｴ ｨｬ02 ﾂ02ｨｪｨｨ ｨｨ ｨｨ ｨｹ04ｨｮ06ｨｰ ｨｮ ( 11 05), ｨ 0406ｨｰ ( 13 N), ｨｺｨｨ ( 02) ｨｨ 00ｨｰ0608 ( 18 F) (ｨｰｨ ｨ 05. 1), ｨｺ06ｨｰ ｨｬ0600ｨｮｨｰ 04ｨ ｨｬ02ｨｴｨ ｨｰｨｹ 09ｨｰｨ ｨ ｨｨ05ｨｹｨｪ0402 ｨｨ0406ｨｰ060704, ｨｨｨｬ0206ｨｴｨｨ ｨｪ0608ｨｬ02 09 ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ01 ｨｬ060502ｨｺｨｮ05ｨ 01, ｨｨ 0708ｨｨ 05ｨｰ06ｨｬ ｨｪ02 ｨｨ04ｨｬ02ｨｪ07ｨｰｨｹ 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ01 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺ 05ｨｰｨｨ01 ｨｬ060502ｨｺｨｮ ｨｰ060704, ｨｨ0907ｨｮ09ｨｺｨ 06ｨｴｨｨ ｨｨｨｰ0806ｨｪ04, 06ｨ 04 ﾂｨｪ06 06ｨ 05ｨ 01ｨ 06ｨｰ ｨｪｨ 09ｨｰ0605ｨｹｨｺ ｨｺ06ｨｦ ｨｮ010205ｨｹｨｪ06ｨｦ 08ｨ 01ｨｨ06ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06, ﾂｨｰ ｨｮ- ﾂ02ｨｪｨｨ07 ｨｨｨｪｨｰ ｨｮ06ｨｴ02ｨｦ ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ, ｨｺｨ ｨｺ 0708ｨ 09ｨｨ0506, ｨ 0409ｨ 02ｨｰ ｨｰｨ ｨｰ06 ﾂｨｪ06 06 ﾂ02ｨｪｨｹ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06 ｨｺ060806ｨｰｨｺｨｨｨｦ ｨｨ ｨｮ08ｨ 0907ｨ 01ｨ ｨｨ0406ｨｰ , ｨｨ ｨｹ04ｨｮ02ｨｬ , ｨ 09ｨｰ09ｨｮ02ｨｰ 09ｨｪｨｨ0302ｨｪｨｨ ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 ｨｨ ｨｰ ｨｨｨｰｨｹ ｨｰ0608ｨｪ0402 ｨｨ ｨ ｨｪｨｨ07 ﾂ ｨｺ060806ｨｰｨｺｨｨ ｨｬ0203ｨｮｨｰｨｺｨｨ ｨｬ02ｨｪｨｨ. 06ｨ ｨ 05ｨｨ02ｨ 1 08ｨｨ04ｨｨ ﾂ0209ｨｺｨｨ02 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺｨｨ 0609ｨｪ0609ｨｪ ｨｨｨｰ0806ｨｪｨｨ0907ｨｮ09ｨｺｨ 06ｨｴｨｨ01 ｨｨ0406ｨｰ ｨｰ ｨｨ ｨｮ08ｨ 0907ｨ 01ｨ (ｨｬｨｨｨｪ) 0205ｨｨｨｪｨ ｨ 0200ｨ (ｨｬｨｬ) 11 C 20,4 4,1 13 N 9,96 5,4 O 2,07 8,2 18 F 109,8 2, , 0708ｨｨｨｬ02ｨｪ0702ｨｬ , ｨｰ0907 ｨｨ05ｨｨ ｨｬ02- ﾂ02ｨｪ04ｨｬｨｨ 0209ｨｰ0209ｨｰ0902ｨｪｨｪ04ｨｬｨｨ 0902ｨｴ0209ｨｰ09ｨ ｨｬｨｨ, 0708ｨｨ09ｨｮｨｴｨｨｨｬｨｨ ｨ ｨｪｨｨ04ｨｬｨｮ, ｨｨ05ｨｨ ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨ ｨｪｨ ｨ ｨｬｨｨ ｨｰｨ ｨｺｨｨ ｨｴ0209ｨｰ ｨｨｨｬ020806ｨｬ 01ｨｨｨｬｨｨ ﾂ0209ｨｺ ｨ ｨｪｨ ｨ ｨｬ060302ｨｰ 0905ｨｮ03ｨｨｨｰｨｹ 18 F-0005ｨｮ ｨｨ06ｨｺ09ｨｨ000506ｨｺ0604ｨ (080201), 09 ｨｺ06ｨｰ060806ｨｦ ｨｬ060502ｨｺｨｮ ｨｺ ｨ ｨｬ02ｨｪ02ｨｪ ｨｨ0406ｨｰ060706ｨｬ 18 F. 0308ｨｨｨｬ020806ｨｬ 0209ｨｰ0209ｨｰ0902ｨｪｨｪ ｨｮｨ 09ｨｰ08ｨ ｨｰｨ ｨｰ ｨ, ｨｬ02 ﾂ02ｨｪｨｪｨ (H 2 O). 09ｨ 08ｨ ｨｺｨｰ0208 ｨｪｨ ｨｺ ｨｪｨｨ ｨ 09ｨｨ09ｨｨｨｰ 06ｨｰ ｨｦ09ｨｰ09. 01ｨ 0708ｨｨｨｬ0208, H 2 O 08ｨ ｨｰ ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨｬ ｨｬｨｮ ｨｺ ｨｰ06ｨｺｨｮ (0008) ｨｪｨｺｨｨ 0008 ｨｨ ｨｹ04ｨｮ06ｨｰ ｨ 0002ｨｪｨｰ04, ｨ 0601ｨｪ ｨｨｨｪｨｨｨｺｨ 06ｨｴｨｨ02 09ｨｺ090604ｨｹ 0002ｨｬｨ ｨｰ0605ｨｪ020200ｨ 05ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨ ｨ 08ｨｹ0208 (ｨｰｨ ｨ 05. 2). 06ｨｰｨｨ 0902ｨｴ0209ｨｰ09ｨ ｨｪｨ ｨ 06ｨｰ 0706ｨｰ06ｨｺ0604ｨ 09ｨｨ09ｨｨｨｬ04ｨｬｨｨ (flow-limited), ｨｺ0605ｨｹｨｺｨｮ ｨｨ01 ｨｪｨ ｨｺ ｨｪｨｨ ｨｴ0209ｨｰ0902 ｨｬ060400ｨ ｨｰ ｨｺ , ﾂ02ｨｬ 01ｨｨ0000ｨｮ04ｨｨ02ｨｦ ｨｴ0209ｨｰ0906 ｨｬ060400ｨ. 0308ｨｨ 05ｨｰ06ｨｬ 06ｨ 04 ﾂｨｪ ｨｨｨｬ02ｨｪ0706ｨｰ 08ｨ 0405ｨｨ ﾂｨｪ0402 ｨｬ0601ｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ ｨｬ02ｨｰ0601ｨｨｨｺｨｨ 0802ｨｰｨｨ ｪ 01ｨｬｨｨ01ｨｰｨ (Kety S.S., Schmidt C.F., 1948), 09 ｨｺ06ｨｰ060806ｨｦ ｨｪｨｨ09ｨ 06ｨｰ ｨｰ020702ｨｪｨｨ ｨｪｨ ｨｺ ｨｪｨｨ07 ｨｨ 0904ｨｬ0409ｨ ｨｪｨｨ ｨ 08ｨ ｨｰｨ ｨｪｨ ｨｺｨ 07ｨｨ ｨｪ06ｨｬ ｨｮ080609ｨｪ ｨ 0408ｨ ｨ 06ｨｰｨ ｨｪ ｨｰｨ ｨｺ0302 ｨｬ02ｨｰ0601 ｨｨ ｨ ｨｪｨｨ07 ｨｺ ｨｰ06ｨｺｨ 0708ｨｨ ｨｪ ｨｪ06ｨｦ ｨｨｨｪ00ｨ ｨｨｨｨ O (Jones T. et al., 1976) ｨｰ06ｨｬ 0905ｨｮ ﾂｨ 02 ｨｮ09ｨｰ06ｨｦ- ﾂｨｨ09ｨ 07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07 H 2 O 09 ｨｬ ｨｰ0907 ｨｮ080609ｨｪ02ｨｬ 0008 ｨｨ ｨｨ060106ｨｬ ｨｮ08ｨ 0907ｨ 01ｨ O (2 ｨｬｨｨｨｪ) , ｨｰｨ ｨｺ 0302 ｨｺｨ ｨｺ ｨｨ ｨｺ0604ｨ, ｨｪｨｨｨｺｨ 02ｨｰ 09 ｨｺ0502ｨｰｨｺｨｮ ｨｨ ｨｨ05ｨｨ08ｨｮ02ｨｰ ｨｬ02ｨｪｨｰ06ｨｬ 0002ｨｺ0906ｨｺｨｨｨｪｨ 0406ｨｦ ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ 06ｨ 08ｨ 04ｨｮ06ｨｴ ｨｨ 05ｨｰ06ｨｬ ｨｺ ｨ ｨｰｨ ｨ ｨｰ ｨｪ ｨ 02ｨｰ ｨ 05ｨｹｨｪ02ｨｦ0302ｨｬｨｮ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨｮ, ｨ ｨｪｨ ｨｺｨ 0705ｨｨ09ｨ 02ｨｰ ｨｪｨｮｨｰ08ｨｨ ｨｺ0502ｨｰｨｺｨｨ ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨｮ080609ｨｪ06 06ｨ ｨｬ02ｨｪｨ ｨｺ , ｨｺｨ ｨｺ ｨｨ 0108ｨｮ00ｨｨ , ｨｬ02 ﾂ02ｨｪｨｪ F, ｨｨｨｬ0202ｨｰ 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ ｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨｨ ｨｮ08ｨ 0907ｨ 01ｨ (110 ｨｬｨｨｨｪ). 06ｨｰ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｰｨ ｨｰ06 ﾂｨｪ06, ﾂｨｰ06ｨ 04 09ｨｨｨｪｨｰ0204ｨｨ080609ｨ ｨｰｨｹ 14 06ｨ ｨ 05ｨｨ02ｨ 2 09ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨｴ0209ｨｰ09ｨ, ｨｬ02 ﾂ02ｨｪｨｪ ｨｨｨｰ0806ｨｪｨｨ0907ｨｮ09ｨｺｨ 06ｨｴｨｨｨｬｨｨ ｨｨ0406ｨｰ0607ｨ ｨｬｨｨ ｨｨ 0708ｨｨｨｬ02ｨｪ0702ｨｬ ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 [ O]H 2O, [ O]ｨ ｨｮｨｰｨ ｨｪ0605, C O ｨｦ ｨｺ ｨｰ06ｨｺ 11 CO, C O 02ｨ ｨｲ02ｨｬ ｨｺ080609ｨｨ 09 ｨｬ O 2 02ｨ ｨｬ02ｨｪ ｨｺｨｨ ｨ [ 18 F]0005ｨｮ ｨｺ09ｨｨ000506ｨｺ0604ｨ 02ｨ ｨｬ02ｨｪ ｨｺ [ 11 C]ｨｬ02ｨｰｨｨ06ｨｪｨｨｨｪ, [ 11 C]010605ｨｨｨｪ, 02ｨ ｨｬ02ｨｪ ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰ [ 11 C]ｨｰｨｨ080604ｨｨｨｪ, [ 11 C]0502ｨｦ02ｨｨｨｪ, [ 11 C]09ｨ 05ｨｨｨｪ, [ 11 C]0002ｨｪｨｨ05ｨ 05ｨ ｨｪｨｨｨｪ [ 11 C]07ｨ 05ｨｹｨｬｨｨｨｰｨｨｨｪ0609ｨ 07 ｨｺｨｨ090506ｨｰｨ, 02ｨ ｨｬ02ｨｪ ｨ 0601ｨｪ ｨｨ08ｨｪ0401 ｨｺｨｨ090506ｨｰ [ 11 C]ｨｬ02ｨｰｨｨ ｨｰｨ 0102ｨｺｨ ｨｪ0609ｨ 07 ｨｺｨｨ090506ｨｰｨ [ 13 N]0005ｨｮｨｰｨ ｨｬｨ ｨｰ, [ 13 N]ｨ 05ｨ ｨｪｨｨｨｪ, 08ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｰ08ｨ ｨｪ09ｨｬｨｨｨｪｨ 04 [ 13 N]ｨ 0907ｨ 08ｨｰｨ ｨｰ [ 11 C]08ｨ ｨｺ ｨｨ01, ｨ ｨｬｨｨｨｪ ｨｰ [ 11 C]ｨｬ02ｨｰｨｨ050907ｨｨ ｨｪ, 6-[ 18 F]0005ｨｮ ｨ ｨｬｨｨｨｪ, [ 18 F]0907ｨｨ ｨｪ [ 11 C]ｨｺｨ ｨｪｨｰｨ ｨｪｨｨ05 [ 11 C]05ｨｰ060800ｨｨｨｪ, 0207ｨｨｨ ｨｰｨｪ ｨｰ [ 11 C]01ｨｨ070802ｨｪ060800ｨｨｨｪ [ 11 C]0005ｨｮｨｬｨ 0402ｨｪｨｨ05, 0902ｨｪ040601ｨｨｨ ｨｨｨｪ ｨｰ [ 11 C]0005ｨｮｨｪｨｨｨｰ08ｨ ｨ ｨｬ [ 11 C]09ｨｺ ｨ ｨｬｨｨｨｪ [ 11 C]ｨ 02ｨｪ04ｨｰ080607ｨｨｨｪ, [ 11 C]ｨｰ080607ｨｨ05ｨ 02ｨｪ04ｨｨ05ｨ ｨｰ, [ 11 C]ｨｬ02ｨｰｨｨ0507ｨｨ070208ｨｨ01ｨｨ05ｨ 02ｨｪ04ｨｨ05ｨ ｨｰ 00ｨｮ09ｨｺｨ 08ｨｨｨｪ ｨｨｨｪ020800ｨｨ ﾂ0209ｨｺｨｨ ｨｰ [ 11 C]ｨｪｨｨｨｺ06ｨｰｨｨｨｪ 01ｨｨｨｺ06ｨｰｨｨｨｪ ｨ 0202ｨｰｨｨ ｨｨｨｪ ｨｰ [ 18 F]ｨ 05ｨｰｨ ｨｪ090208ｨｨｨｪ, [ 18 F]0902ｨｰ ｨｪ ｨｰ06ｨｪｨｨｨｪ ｨｰ [ 11 C] 0106ｨｺ090207ｨｨｨｪ 01ｨｨ09ｨｰｨ ｨｬｨｨｨｪ ｨｰ [ 18 F]0005ｨｮ L-DOPA, 4-[ 18 F]0005ｨｮ m-ｨｰｨｨ080604ｨｨｨｪ ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺｨ ｨ ｨｬｨｨｨｪ020800ｨｨ ﾂ0209ｨｺｨ 07 09ｨｨ09ｨｰ02ｨｬｨ [ 11 C] ｨｨｨｪ, ｨｪ020800ｨｨ ﾂ0209ｨｺｨｨ02 06ｨｺ06ｨｪ ﾂｨ ｨｪｨｨ07 [ 18 F]0005ｨｮ060806ｨｬ02ｨｰｨ 08ｨ ｨｬｨｨｨｪ0605 [ 11 C]ｨｰｨｨｨｬｨｨ01ｨｨｨｪ, [ 18 F] 0005ｨｮ ｨｺ09ｨｨｨｮ08ｨｨ01ｨｨｨｪ, [ 76 Br] ｨ 0806ｨｬ ｨｺ09ｨｨｨｮ08ｨｨ01ｨｨｨｪ, [ 124 I] ｨｦ ｨｺ09ｨｨｨｮ08ｨｨ01ｨｨｨｪ 05ｨｨｨｪｨｰ ( ｨｨ000208ｨ 02ｨｨ07 ｨｺ0502ｨｰ06ｨｺ) [ 11 C] ｨｪｨｨ ｨｪ06ｨ ｨｬｨｨｨｪ06ｨｺ09ｨｨ01ｨ 04ｨ 00 (ｨ 09ｨｰ080602ｨｨｨｰ04) ｨｪ06ｨｬ ｨｬ0209ｨｰ02, ｨ ｨｨｨｰｨｹ 09ｨ ｨｬ ｨｨ ｨ ｨｪｨｨ02 ｪ ｨｮ0006ｨｬ. 00 ｨｪ02ｨｺ06ｨｰ ｨｮ ﾂｨ 0701 ｨｨ ｨｹ04ｨｮ06ｨｰ ｨ ｨｪｨ ｨｴ0209ｨｰ09ｨ ｨｨ05ｨｨ ｨ 08ｨ ｨｰ, ｨｨ04ｨ ｨｨ08ｨ ｨｰ0205ｨｹｨｪ ｨ 06ｨｴｨｨｨｦ ｨｺｨ ｨｺｨｨｨｬ-05ｨｨｨ ｨｬ02ｨｪｨｰ06ｨｬ ｨｨ ｨｨ040605ｨｨ08ｨｮ06ｨｴｨｨｨｦ ｨ ｨｺｨｰｨｨ09ｨｪｨｮ ｨｬｨｮ, ﾂｨｰ ｨｰ ｨｪｨｨｨｰｨｹ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 01ｨ ｨｪｨｪ ｨｬ02ｨｪｨｰｨ. 08ｨ ｨｺ 0708ｨ 09ｨｨ0506, ｨｰｨ ｨｺｨｨ ｨ ｨｺ02ｨｨｨｨ ｨｰ0907 ｨｪ0206ｨ 08ｨ ｨｰｨｨｨｬ04ｨｬｨｨ ｨｨ ｨｰ06ｨｬｨｮ ｨｺｨ 07 ｨｮ010205ｨｹｨｪｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨｨｬ0202ｨｰ ｨ 06 09ｨ 03ｨｪ ｨｪｨ ﾂ02ｨｪｨｨ ｨｺｨ ﾂ0209ｨｰ ｨｨｨｬ0208ｨ ｨｬ0603ｨｪ ｨｨ090209ｨｰｨｨ ｨｨ ｨｹ040609ｨ ｨｪｨｨ02 [ 11 05] ｨｪｨｨ05ｨ ｨｪｨｺｨｨ ｨｮ080609ｨｪ07 ｨｬ06ｨｪ06ｨ ｨｬｨｨｨｪ06ｨｺ09ｨｨ01ｨ (Fowler J.S. et al., 1987) ｨｨ ｨ ｨｪｨｨ ｨｰ ｨｨ ｨｹ04ｨｮ06ｨｰ 08ｨ 01ｨｨ0605ｨｨ00ｨ ｨｪ0104 ｪ 0902ｨｴ0209ｨｰ09ｨ, ｨ 06ｨｴｨｨ ｨｨｨｰ0806ｨｪｨｨ0907ｨｮ09ｨｺｨ 06ｨｴｨｨ02 ｨｨ0406ｨｰ ｨｬ060502ｨｺｨｮ05ｨ ｨｬｨｨ ( ｨｰ0608ｨ ｨｬｨｨ), ｨｺ06ｨｰ ｨｨｨｬ0206ｨｰ ｨｨ ｨｰｨｪ ｨ 08ｨｬｨ ｨｺ06ｨｺｨｨｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｦ09ｨｰ09ｨ (Mintun M.A. et al., 1984; Perlmutter J.S., Moerlein S.M., 1999). 08ｨ ｨｺ 0708ｨ 09ｨｨ0506, ｨｨ ｨｹ04ｨｮ06ｨｰ ｨｬ02ｨｰ0601 ｨｺｨ 08ｨｰｨｨ080609ｨ ｨｪｨｨ07, 0708ｨｨ ｨｺ06ｨｰ060806ｨｬ ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨ02 ｨｨ ｨｰ08ｨｨ08ｨｮ02ｨｰ 08ｨ ｨｪｨｨ02 ｨｰ ｨｨ05ｨｨ ｨｨｨｪ ｨｰ0608ｨ 09 ｨｬ ｨｨ 05ｨｰ06ｨｬ ｨｮ ｨｪｨｹ ｨｪｨ ｨｺ ｨｪｨｨ ｨｰ ｨｨｨｬｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906ｨｬ (ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ02ｨｦ) ｨｰ ｨ ｨｪｨｪ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ ｨｨ ｨｰ0906ｨｬ 05ｨｨ00ｨ ｨｪ01ｨ ｨｺ 05ｨｰｨｨｨｬ ｨｰ0608ｨ ｨｬ ｨｰｨｪ060302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｰ ｨｺ ｨｺ06ｨｪ09ｨｰｨ ｨｪｨｰ02 01ｨｨ ｨｨｨ 02ｨｨｨｨ 05ｨｨ00ｨ ｨｪ ﾁ ﾁ ｨC 01 2 (28) ｨC III/IV 2002

3 1301ｨ, ｨｰｨ ｨｺ ｨｪｨ ｨ 02ｨｬ04ｨｦ 0706ｨｰ02ｨｪ02ｨｨｨ ｨ ｨｪｨｨ07, ｨｰ ｨｪ0609ｨｪ04ｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ0902ｨｪｨｪ04ｨｬ 07ｨ 08ｨ ｨｬ02ｨｰ0806ｨｬ, ｨｪｨｨ09ｨ 02ｨｬ04ｨｬ 0708ｨｨ ｨｨ ｨ ｨｪｨｨｨｨ ｨｰ ｨｨ00ｨ ｨｪ ｨ 06ｨｰ0907 ｨｺｨ ｨｺ ｨｨ00ｨｨ ﾂ0209ｨｺ06ｨｬｨｮ, ｨｰｨ ｨｺ ｨｨ ｨｪ ｨｨ00ｨｨ ﾂ0209ｨｺ06ｨｬｨｮ ｨ ｨｪｨｨ , ｨｺｨ ｨｺ 0708ｨ 09ｨｨ0506, ｨｨｨｪｨｰ ｨｰｨ ｨｰ ｨｨ00ｨｨ ﾂ0209ｨｺ ｨ ｨｪｨｨ02, ｨｰ ｨｰｨｹ ｨ ｨｪｨｨ02 ｨｨｨｬ02ｨｪｨｪ06 09 ｨｨｨｪｨｰ ｨｮ06ｨｴｨｨｨｬｨｨ ｨｰ0608ｨ ｨｬｨｨ. 0005ｨｨ07ｨｪｨｨ02 ｨｪ ｨｨ00ｨｨ ﾂ0209ｨｺ ｨ ｨｪｨｨ07 ｨｬ0603ｨｪ06 ｨｮ09ｨｰ08ｨ ｨｪｨｨｨｰｨｹ 07ｨｮｨｰ02ｨｬ 06ｨｰ0902 ﾂ02ｨｪｨｨ ｨｪｨ. 00 ｨｺｨ ﾂ0209ｨｰ ｨｪ ｨｨ ｨｹ04ｨｮ02ｨｰ0907 ｨｮ ﾂｨ 09ｨｰ06ｨｺ ｨｬ060400ｨ 09 ｨｪｨｨ04ｨｺ06ｨｦ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ02ｨｦ 01ｨ ｨｪｨｪ ｨｰ ｨｨ 0904 ﾂ0209ｨｰｨｹ ｨｮ ｨｪｨｹ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｪ ｨｮ ﾂｨ 09ｨｰｨｺｨ ｨｨ04 ｨｰｨ ｨｺ ｨｨｨｪｨｰ ｨｮ06ｨｴ02ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ, ｨｰ ｨｮ ﾂ02ｨｪｨｪｨ 07 08ｨ 04ｨｪｨｨ02ｨ ｨ ｨｮ0102ｨｰ 06ｨｰ08ｨ 03ｨ ｨｰｨｹ 0706ｨｰ02ｨｪ02ｨｨｨ ｨ ｨｪｨｨ ｨｰ ｨ ｨｪｨｪ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ. 05ｨｨｨｪｨｰ ｨｨ ｨ ｨｪｨｨ ｨｰ ｨｰ0201ｨｪｨｨ- ﾂ0209ｨｺｨｨ ｨ ｨ ｨｪ, ﾂ02ｨｬ ｨｨ ｨｰ0906 H 2 O ｨｨ05ｨｨ ｨｪ02 ﾂｨｪ04ｨｦ ｨｮｨｺｨｰ ｨｰｨ ｨｺ ｨｨｨｪｨｰ0204ｨ ｨｪ 06ｨ 05ｨ 01ｨ ｨｰｨｹ ｨｺ06ｨｦ ｨｮ010205ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06, ｨ 04ｨｰｨｹ 09ｨｰ0208ｨｨ05ｨｹｨｪ04ｨｬ, ｨ ｨｰｨ ｨｺ ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ ｨｨ 08ｨ 01ｨｨ0601ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ ﾂｨｨ09ｨｰ04ｨｬ ｨｬ02 ｨｰ060006, 06 ﾂ02ｨｪｨｹ 09ｨ 03ｨｪ06, ﾂｨｰ06ｨ 04 08ｨ ｨｪｨｨ ｨｺｨ ｨｺ ｨｬ0603ｨｪ06 09 ｨｬ02ｨｪｨｹ0302ｨｦ 09ｨｰ020702ｨｪｨｨ 04ｨ 09ｨｨ ｨｰ 0008 ｨｨ ｨｰ08ｨ ｨｪ ｨｰｨ ﾂ ｨｬｨ ｨｰ0605ｨｪ020200ｨ 05ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨ ｨ 08ｨｹ ﾂ02ｨｪ0402 ｨ ｨｪｨ ｨｨ ｨｪ02ｨｦ0806ｨｰ08ｨ ｨｪ09ｨｬｨｨｨｰｨｰ , ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｪ ｨｨ ｨ ｨｪｨｨｨｦ ｨｮ ﾂ ｨｺｨ, ｨ 0405ｨｨ 08ｨ 0408ｨ ｨ 06ｨｰｨ ｨｪ ｨｬｨｪ0600ｨｨ01 ｨｬ0201ｨｨｨ ｨｰ0608ｨｪ ｨｨ09ｨｰ02ｨｬ, 09ｨｺ0506 ﾂｨ ｨ ｨｬｨｨｨｪ , ｨ 02ｨｪ040601ｨｨｨ ｨｨｨｪ , ｨｰ06ｨｪｨｨｨｪ , 00ｨｨ09ｨｰｨ ｨｬｨｨｨｪ , 0607ｨｨｨ ｨｰｨｪ0402, ｨｪｨｨｨｺ06ｨｰｨｨｨｪ ｨ 0202ｨｰｨｨ ｨｨｨｪ ｨｨ ｨｬｨｮ09ｨｺｨ 08ｨｨｨｪ ｨｨｨｪ020800ｨｨ ﾂ0209ｨｺｨｨ ｨｰ (09ｨｬ. ｨｰｨ ｨ 05. 2) (Frost J.J. et al., 1985; Savic I. et al., 1988; Nordberg A. et al., 1990; Dewey S.L. et al., 1993; Iinuma K. et al., 1993; Dupont S. et al., 1996; Meltzer C.C. et al., 1998) ｨ ｨｪｨｮ06 ｨｨｨｪ000608ｨｬｨ 02ｨｨ06 ｨｬ0603ｨｪ06 ｨｪｨ ｨｦｨｰｨｨ ｨｨｨ 05ｨｨ04ｨｨ080609ｨ ｨｪｨｪ ｨ ｨ 01, ｨｴ02ｨｪｨｪ ｨｨ ｨ ｨｪｨｨ07ｨｬ 06ｨｰ010205ｨｹｨｪ0401 ｨｬ0201ｨｨｨ ｨｰ0608ｨｪ ｨｨ09ｨｰ02ｨｬ ｨｨ ｨｰ (Perlmutter J.S. et al., 1986; Duncan J.S., 1999; Meltzer C.C., 1999; Perlmutter J.S., Moerlein S.M., 1999; Paterson D. et al., 2000; Passchier J., van Waarde A., 2001). ｧｬｧｰｧｭｧｪｧｹｧｦｧｳｧｴｧ ｧｦｧｯｧｯｧ ｧﾁ'ｧｰｧｸｧｦｧｯｧｬｧ 07ｨｪｨｨｨｺｨ 05ｨｹｨｪ0609ｨｰｨｹ ｨｰ06ｨｨｨｰ, 09 ﾂｨ 09ｨｰｨｪ0609ｨｰｨｨ, 09 ｨｰ06ｨｬ, ﾂｨｰ06 05ｨｰ06ｨｰ ｨｬ02ｨｰ ｨｰ ｨｺ0605ｨｨ ﾂ0209ｨｰ0902ｨｪｨｪ ｨｪｨｨｨｰｨｹ 0609ｨｪ0609ｨｪ ｨ 08ｨ ｨｬ02ｨｰ0804 ｨｬ ｨｺ ｨ 08ｨ ｨｴ02ｨｪｨｨ07 ｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ. 08 ｨｪｨｨｨｬ 06ｨｰｨｪ060907ｨｰ0907: 0008 (ｨｬ05/ ｨｬｨｨｨｪ); 06ｨ ｨｲ02ｨｬ ｨｺ080609ｨｨ, 02ｨｨ08ｨｺｨｮ05ｨｨ08ｨｮ06ｨｴ02ｨｦ ｨｮ01ｨ 01 ｨｬ060400ｨ (020800, ｨｬ05/100 00); 0008ｨ ｨｺ02ｨｨ07 ｨｨ ﾂ02ｨｪｨｨ07 ｨｺｨｨ ｨ (080608) ｨｨ ｨｨｨｰ02ｨｺｨ 06ｨｴ02ｨｦ ｨ 08ｨｰ0208ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｺ080609ｨｨ; ｨｮ ｨｪｨｹ 06ｨ ｨｬ02ｨｪｨ ｨｺｨｨ ｨ (070208, ｨｬ05/ ｨｬｨｨｨｪ); ｨ ｨｰｨ ｨｺ0302 ｨｮ ｨｪｨｹ 06ｨ ｨｬ02ｨｪｨ ｨｺ (070201, ｨｬ05/ ｨｬｨｨｨｪ). 0604ｨｮ ﾂ02ｨｪｨｨ02 05ｨｰｨｨ01 07ｨ 08ｨ ｨｬ02ｨｰ ｨｪｨ - ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ 09ｨｰ090609ｨ ｨｪ09ｨｰ090609ｨ ｨｪｨｨ06 04ｨｪｨ ｨｪｨｨｨｦ 06 ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ 01ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨ ｨｺｨｰｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｬ060400ｨ ｨｨ ｨ ｨｺ02ｨｨ ｨｰ0902ｨｰ ｨｪｨ 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｮ06 09ｨｰｨｨｨｬｨｮ050702ｨｨ06, 08ｨ 0405ｨｨ ﾂｨｪ ｨ ｨ ｨ ｨｪｨｨ07, ｨ ｨｰｨ ｨｺ0302 ｨｪｨ ｨｬ0201ｨｨｨｺｨ ｨｬ02ｨｪｨｰ0604ｨｪ0402 ｨｨ 01ｨｨ08ｨｮ0800ｨｨ ﾂ0209ｨｺｨｨ ｨｦ09ｨｰ09ｨｨ ｨ ｨｪｨ ﾂ02ｨｪｨｨ02 ｨｨｨｬ0205ｨｨ ｨｨ ｨ ｨｪｨｨ07 09ｨｰｨ 01ｨｨｨｦ 08ｨ 0409ｨｨｨｰｨｨ07 ｨｨ0302ｨｬｨｨｨｨ ｨｬ ｨ 0708ｨｨ ｨ ｨ 09ｨｺｨｮ050708ｨｪ ｨ ｨ ｨ ｨｪｨｨ0701, 0708ｨｨ 05ｨｰ06ｨｬ ｨ 0405ｨｨ ｨｨ09ｨ ｨｪ04 ｨｨ05ｨｨ 0102ｨｰｨ 05ｨｹｨｪ06 ｨｮｨｰ06 ﾂｨｪ02ｨｪ04 ｨｪ02ｨｺ06ｨｰ ｨ ｨｰ0600ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨｪ06ｨｬ02ｨｪ04, ｨｰｨ ｨｺｨｨ02, ｨｪｨ 0708ｨｨｨｬ0208, ｨｺｨ ｨｺ 00ｨｪｨｨｨｴｨ ｨｮ04ｨｨ0703, 00ｨｨ0302ｨｬｨｨ ﾂ0209ｨｺｨ ｨｮｨｰ02ｨｪｨｹ03 ｨｨ 0001ｨｨｨ 03ｨｨ0403 (Baron J.C. et al., 1980, 1981; Powers W.J. et al., 1984; Hakim A.M., 1987; Baron J.C., 1991, 1996, 2001; Grubb R.L. et al., 1998; Derdeyn C.P. et al., 1999) ｨｬｨｨｨｪ 00ｨｪｨｨｨｴｨ ｨｮ04ｨｨ0703 ｨ ｨｪ J.C. Baron ｨｨ 0906ｨ 09ｨｰ0608ｨ ｨｬｨｨ (1981) ｨｨ09ｨ ｨｪｨｨ07 ｨｪ ｨｰ0902ｨｰ09ｨｰ09ｨｨ07 ｨｺ ｨｰ06ｨｺｨ ｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ, 0708ｨｨ ｨｺ06ｨｰ060806ｨｬ 09ｨｪｨｨ0302ｨｪｨｨ ｨｪ ｨ 02ｨｰ ｨｨ06ｨｪｨ 05ｨｹｨｪ04ｨｬ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02ｨｬ , ｨｺ0605ｨｹｨｺｨｮ ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪ ｨｰｨｮ070502ｨｪｨｨ02 ｨｺｨｨ ｨ ｨｺ06ｨｬ0702ｨｪ09ｨｨ08ｨｮ02ｨｰ0907 ｨｮ09ｨｨ0502ｨｪｨｨ02ｨｬ ｨｺ09ｨｰ08ｨ ｨｺ02ｨｨｨｨ ｨｨ04 ｨ 08ｨｰ0208ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｺ080609ｨｨ (Baron J.C., 1991). 0308ｨｨ 05ｨｰ06ｨｬ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ ｨ 09ｨｰｨ 02ｨｰ ｨｨ ﾂｨｨｨｪｨ ｨｰ06ｨｰ 0002ｨｪ06ｨｬ02ｨｪ ｨｬ060302ｨｰ 06ｨｰｨｬ02 ﾂｨ ｨｰｨｹ ｨｰ02 ﾂ02ｨｪｨｨ ｨｨ0601ｨ ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪ0609ｨｰｨｨ ｨｬ ｨｺ ｨ 08ｨ ｨｴ02ｨｪｨｨ ｨｰｨｹ ｨ 0409ｨｨｨｰｨｨ07 ｨｪ0206ｨ 08ｨ ｨｰｨｨｨｬ ｨ 0302ｨｪｨｨｨｦ (ｨｨｨｪ00ｨ 08ｨｺｨｰｨ ｨｬ060400ｨ ) ｨ 09ｨｪ ｨｬ02ｨｪｨｪ06ｨｦ ｨｺ06ｨｪ ｨｨｨｨ 00ｨｨ0302ｨｬｨｨ ﾂ0209ｨｺｨ ｨｮｨｰ02ｨｪｨｹ03 ｪ 05ｨｰ06 06ｨ 05ｨ 09ｨｰｨｹ ｨｬ060400ｨ 09 ｨｮ00ｨｪ02ｨｰ02ｨｪｨｪ06ｨｦ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06, ｨｪ ｨ ｨｪ02ｨｪｨｪ06ｨｦ 03ｨｨ04ｨｪ ｨ ｨｪ0609ｨｰｨｹ06 ｨｪ020809ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ, 08ｨ ｨ 00ｨ 06ｨｴｨ ｨｨ000208ｨｨｨｨ 06 ﾂｨ 00ｨ ｨｨ0302ｨｬｨｨｨｨ, ｨｺ06ｨｰ060804ｨｦ ｨ 02ｨｰ0907 ｨｪ02ｨｺ080604ｨｮ ｨｰ09ｨｨ02 ｨｪ0206ｨ 08ｨ ｨｰｨｨｨｬ ｨ 0302ｨｪｨｨｨｦ 0902ｨｴ0209ｨｰ09ｨ ｨｬ060400ｨ. 02ｨｰ ｨｰ060006, ｨｺｨ ｨｺｨ 07 ﾂｨ 09ｨｰｨｹ ｨｪ02ｨｦ0806ｨｪ ｨ 05ｨ 09ｨｰｨｨ 00ｨｨ0302ｨｬｨｨ ﾂ0209ｨｺ06ｨｦ ｨｮｨｰ02ｨｪｨｨ ｨｨ0902ｨｰ03 ｨｨ ｨｰｨ ｨｪ0609ｨｨｨｰ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ, 09 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ 04ｨ 09ｨｨ09ｨｨｨｰ ｨｨ ｨｨ0302ｨｬｨｨ ﾂ0209ｨｺ ｨｨｨｪ09ｨｮ05ｨｹｨｰｨ. 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 05ｨｰ06ｨｰ 0002ｨｪ06ｨｬ02ｨｪ 00ｨ ｨｺｨｰｨｨ- ﾂ0209ｨｺｨｨ ｨｰ ｨ ｨｰ0600ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨｨｬ 05ｨｺ09ｨｨ09ｨ 0502ｨｪｨｰ06ｨｬ ｨｰｨ ｨｺ ｨ 03ｨｪ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ ｨｪ07ｨｰｨｨ07, ｨｺｨ ｨｺ 00ｨｰ0208ｨ ｨｰｨｨ ﾂ0209ｨｺ ｨｺｨｪ0603, 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ06ｨｴ ｨｨ0601, ｨｬ07 ｨｺ06ｨｰ ｨｮ02ｨｰ 0603ｨｨ01ｨ ｨｰｨｹ ｨｪｨ ｨｨ ｨｦ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0502 ﾂ02ｨｪｨｨ07 (Lassen N.A. et al., 1981; Baron J.C., 1991, 1996; Ginsberg M.D., Pulsinelli W.A., 1994; Furlan M. et al., 1996; Heiss W.D., 2000) ｨｨ07 ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ 09 ｨｨｨｪｨｰｨ ｨｺｨｰｨｪ0401 ｨｮ ﾂｨ 09ｨｰｨｺｨ 01 ｨｬ060400ｨ, 08ｨ ｨｪｨｪ0401 ｨｪｨ 08ｨ 0909ｨｰ0607ｨｪｨｨｨｨ 06ｨｰ 06 ﾂｨ 00ｨ ｨｨ0302ｨｬｨｨｨｨ, ｨｪ06 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ ｨｪｨｪ ｨ ｨｪｨｪ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｹ06, 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ02ｨｰ ｨｨ06ｨｪｨ 05ｨｹｨｪ04ｨｬ 09ｨｪｨｨ0302ｨｪｨｨ02ｨｬ 0008, , ｨｨ , ﾂｨｰ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ ｨ ｨｪｨｪ0609ｨｰｨｨ 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺ ｨｰ0902ｨｰ09ｨｰ09ｨｨ ｨｬ0601ｨｨｨｪｨ ｨｬｨｨｨｺｨｨ ｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ (Baron J.C. et al., 1980; Baron J.C., 1991). 0308ｨｨ ﾂｨｨｨｪ06ｨｦ 05ｨｰ ｨｪ06ｨｬ02ｨｪｨ, ｨｪｨ ｨ 02ｨｬ ｨｨｨ 03ｨｨ0406ｨｬ, 0708ｨｨｨｪ07ｨｰ06 09 ﾂｨｨｨｰｨ ｨｰｨｹ ｨｮ00ｨｪ02ｨｰ02ｨｪｨｨ02 ｨｨｨｪｨｰ020008ｨ 05ｨｹｨｪ06ｨｦ 09ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ (Feeney D., Baron J.C., 1986). 0201ｨｪ ｨｬ02ｨｪｨｪｨ 07 ｨｺ0605ｨｨ ﾂ0209ｨｰ0902ｨｪｨｪｨ ｨｪｨｺｨ 0008 ｨｨ ｨｰ 08ｨ 0909 ﾂｨｨｨｰｨ ｨｰｨｹ ｨｨ ｨｰｨｪ060302ｨｪｨｨ02, ｨｺ06ｨｰ ｨｨ04ｨｬ02ｨｪ0702ｨｰ ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ 08ｨ 05ｨｹｨｪ06ｨｬｨｮ ｨｮ04ｨｨ06ｨｪｨｪ06ｨｬｨｮ 01ｨ ｨｪｨｨ06 ｨｨ ｨｬ060302ｨｰ 0905ｨｮ03ｨｨｨｰｨｹ ｨｨｨｪ0102ｨｺ0906ｨｬ ｨｰｨ ｨｺ ｨｪｨ ｨ 02ｨｬ ｨｬ0601ｨｨｨｪｨ ｨｬｨｨ ﾂ0209ｨｺ ｨ, ｨｰ ｨｰｨｹ ｨ ｨｪ0609ｨｰｨｨ ｨｨ09ｨｰｨｨ09ｨｪ0401 ｨｬ ｨｮ ｨ 0903ｨｨ0807ｨｰｨｹ ｨｰ0902ｨｰ ｨｪｨ 09ｨｪｨｨ0302ｨｪｨｨ ｨ 08ｨ 05ｨｹｨｪ ｨｮ04ｨｨ06ｨｪｨｪ ｨ ｨｪｨｨ07, ｨｺｨ ｨｺ 05ｨｰ06 ｨ 0409ｨ 02ｨｰ 0708ｨｨ 09ｨｰ02ｨｪ0604ｨ 01 ｨｨ05ｨｨ 06ｨｺｨｺ050604ｨｨ0701 ｨｬｨ 00ｨｨ09ｨｰ08ｨ 05ｨｹｨｪ0401 ｨ 08ｨｰ0208ｨｨｨｦ ﾁ ﾁ ｨC 01 2 (28) ｨC III/IV 2002

4 0904 (Gibbs J.M. et al., 1984; Sette G. et al., 1989; Schumann P. et al., 1998). ｧｲｧ ｧｩｧ ｧｪｧｴｧｪｧｦ'ｧ ｧｰｧｭｧｰｧ ｧｯｧｰｧ ｧｰ'ｧｮｧｰｧｩｧ ｧ ｧｪ'ｧｰｧｳｧｰｧ ｧｦｧｯｧｯｧｰｧｳｧｴｧｪ'ｧｦｧ ｧｰ'ｧｯｧｰｧｲｧｮｧ ｧｭｧｾｧｯｧｰｧｫ ｧｶｧｪｧｩｧｪｧｰｧｭｧｰｧ ｧｪｧｪ ｨｨ ｨ ｨｪｨｨ ｨｨ05ｨｨ ｨｪｨｺｨｨ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ 01ｨ 08ｨ ｨｺｨｰ0208ｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ ｨｺ ｨｬ ｨ 0409ｨｨｨｰｨｨ07 ｨｬ060400ｨ ﾂ ｨｺｨ (Chugani H.T., Phelps M.E., 1986; Chugani H.T. et al., 1987). 06ｨｰｨｨ ｨｨ ｨ ｨｪｨｨ ｨｨ05ｨｨ, ﾂｨｰ06 ｨｪｨ ｨｨｨ 0605ｨｹ03ｨ 07 ｨｬ02ｨｰｨ ｨ 0605ｨｨ- ﾂ0209ｨｺｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0708ｨｨ ｨｪｨｨｨｨ 06ｨｰｨｬ02 ﾂｨ 02ｨｰ ｨｨ ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｰｨ ｨ 08ｨ ｨ ｨｪｨｨ0701, ｨｰｨ ｨｺｨｨ01, ｨｺｨ ｨｺ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0402 ｨｨ 0109ｨｨ00ｨ ｨｰ0205ｨｹｨｪ ｨｰ ｨｺ ｨ 0605ｨｹ ｨｬ060400ｨ, 0408ｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨ ｨｮ000608, 09ｨｰ ｨｬ060400ｨ ｨｨ ﾂ020809ｨｹ ｨｬ ﾂｨｺｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 05ｨｰｨｨ01 09ｨｰ08ｨｮｨｺｨｰｨｮ08 ｨｮ0708ｨ ｨｰ ｨｪｨｨ02ｨｬ ｨｨ ｨｨ ﾂｨｪ04ｨｬｨｨ ｨ 0204ｨｮ ｨｪ04ｨｬｨｨ ｨｺ09ｨ ｨｬｨｨ ｨｮ ｨｪ ｨｪｨｪ ｨｬ ｨｰ ｨｺｨ ｨｺ 0802ｨ 02ｨｪ06ｨｺ ｨｰｨｨ00ｨ 02ｨｰ ｨｬ ｨ 03ｨｨ04ｨｪｨｨ ｨｨ ｨｨ ﾂｨｪ ｨｺ ｨ ｨｰ0907, ｨｨ ｨｨｨｰ ｨｪｨｨ ｨｰ02ｨｬ02ｨｪｨｪ0401, 09ｨｨ0906 ﾂｨｪ ｨｰ010205ｨ 01 ｨｺ060804, ｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｺ060802, ｨｺ0608ｨｺ ｨ 01 ｨｨ ｨｮ03ｨ 08ｨｨ0701 ｨｬ ﾂｨｺｨ. 0906ｨ ｨｪ ｨｰ ｨｺ ｨ 06ｨｰ0907 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07ｨｬ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ ｨｺ ｨｪｨｨｨｬｨｨ, 0708ｨｨ 05ｨｰ06ｨｬ ｨｪｨｨ ｨｨ ｨｨｨｰ 0706 ｨｪｨ 0708ｨ ｨｪｨｨ06 06ｨｰ 05ｨ ｨｰ0208ｨ 05ｨｹｨｪ ｨｰ ｨｺ ｨｬ0201ｨｨｨ 05ｨｹｨｪ04ｨｬ ｨｨ 06ｨｰ ｨｪｨｨ03ｨｪｨｨ01 06ｨｰ ｨｺ ｨｪｨｨｨｬ. 06ｨｰ06ｨｰ ｨｨ ｨｨｨｰ ｨｨ0601 ｨｬ020301ｨｮ 6-ｨｬ ｨｨ 10-ｨｬ ｨｬ ｨ ｨｬｨｨ ｨｨ ｨ 02ｨｰ0907 ｨ 0409ｨｰ0804ｨｬ 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｺ0600ｨｪｨｨｨｰｨｨ09ｨｪ ｨ ｨｪ0609ｨｰ02ｨｦ. 08 ｨｺ06ｨｪ02ｨｮ ｨ 03ｨｨ04ｨｪｨｨ 04ｨｪｨ ﾂ02ｨｪｨｨ ｨｰｨｨ00ｨ 06ｨｰ ｨｮ080609ｨｪ07, 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ ﾂ ｨｺｨ ｨｨ0806ｨｺ06 ｨｨ ｨｹ040609ｨ 05ｨ 09ｨｹ ｨｪｨｺｨｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｬ060400ｨ 0708ｨｨ ｨｪ02ｨｪｨｨｨｨ 08ｨ 0405ｨｨ ﾂｨｪ ｨｪ ﾂ0209ｨｺｨｨ01, 0109ｨｨ00ｨ ｨｰ0205ｨｹｨｪ0401 ｨｨ ｨｺ0600ｨｪｨｨｨｰｨｨ09ｨｪ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ. 06ｨ ｨｺｨｨ02 ｨｨ ｨ ｨｪｨｨ07 09 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06ｨｪｨｪ04ｨｬｨｨ ｨｪｨ 0008ｨｮ04ｨｺｨ ｨｬｨｨ ｨｨ05ｨｨ 0506ｨｺｨ 05ｨｨ040609ｨ ｨｰｨｹ ｨｮ ﾂｨ 09ｨｰｨｺｨｨ ｨｬ060400ｨ, 06ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ ｨ 0706ｨｪｨｨｨｬｨ ｨｪｨｨ ﾂｨｨ, 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｮ 0408ｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ, 07ｨ ｨｬ07ｨｰｨｹ, 09ｨｪｨｨｨｬｨ ｨｪｨｨ02, ｨ ｨｰｨ ｨｺ ｨｨ07ｨｰｨｨ02 ｨ 0605ｨｨ (Fox P.T. et al., 1984, 1986; Phelps M.E., Mazziotta J.C., 1985; Petersen S.E. et al., 1988; Mintun M.A. et al., 1989; Grafton S.T. et al., 1992; Corbetta M. et al., 1993; Ojemann J.G. et al., 1997) ｨｹ03ｨｨｨｪ09ｨｰ0906 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06ｨｪｨｪ ｨｨ ｨ ｨｪｨｨｨｦ 09 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨｨｨｰ ｨｨ ｨｹ040609ｨ ｨｪｨｨ02ｨｬ , 0905ｨｮ03ｨ ｨｴｨｨ ｨｪｨｺｨｨ 0008, ｨｺ0605ｨｹｨｺｨｮ ｨｨｨｬ02ｨｪｨｪ ｨｨ06ｨｪｨ 05ｨｹｨｪ04ｨｦ 0008 ｨｮ090205ｨｨ ﾂｨｨ09ｨ 02ｨｰ ｨｰ0902ｨｰ ｨｪｨ ｨｲ ｨｪｨｨ02 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｪｨ 0008ｨｮ04ｨｺｨｨ ｨ ｨｪｨｨ ｨｬ06ｨｴｨｹ ｨ ｨｪｨｨｨｬｨ 02ｨｰ ｨｪ02ｨｬｨｪ ｨｬ02ｨｪｨｨ ｨｨ, ｨｺ0605ｨｹｨｺｨｮ ｨｬ02ｨｰｨｨｨｰ0907 ｨｺ060806ｨｰｨｺ0603ｨｨ09ｨｮｨｴｨｨｨｬ ｨｨ0406ｨｰ060706ｨｬ, 06ｨｪ06 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｬｨｪ060006ｨｺ08ｨ ｨｰｨｪ ｨｰ060802ｨｪ06 09 ｨｺ060806ｨｰｨｺｨｨｨｬｨｨ ｨｬ02ｨｪｨｪ04ｨｬｨｨ ｨｨｨｪｨｰ020809ｨ 05ｨ ｨｬｨｨ (Fox P.T. et al., 1984). 05ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｬ ｨｨｨｬｨｮｨｴ0209ｨｰ0906ｨｬ ｨｰｨ ｨｺｨｨ ｨｰ0608ｨｪ0401 ｨｺｨ 08ｨｰｨｨ080609ｨ ｨｪｨｨｨｦ ｨｺ ｨｰ06ｨｺｨ ｨｰ0907 ｨｨ ｨｰ06, ﾂｨｰ06 ｨｺｨ ｨｦ ｨｨ ｨｮ02ｨｬ04ｨｦ ｨｬ060302ｨｰ 09ｨｰｨ ｨｰｨｹ ｨｺ06ｨｪｨｰ ｨｬ ｨ ｨｬ ｨ ｨ 04 ﾂｨｪ ｨｰ06ｨｦ ｨｨ05ｨｨ ｨｨｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06ｨｪｨｪ06ｨｦ ｨ 06ｨｦ ｨｰ06ｨｨｨｰ ｨｨ ｨｪ06ｨｦ ｨｨ05ｨｨ ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ01 07ｨ 08 ｨｨ ｨ ｨｪｨｨｨｦ ｨｺ06ｨｪｨｰ080605ｨｹｨｪ0401 ｨｮ ｨｨ (ｨｺｨ ｨｺ 0708ｨ 09ｨｨ0506, ｨｺ0602) ｨｨ 0708ｨｨ ｨｪｨ 0008ｨｮ04ｨｺ02 (ｨｨｨｪ060001ｨ 0708ｨｨ ｨ ｨｰ0205ｨｹｨｪ ｨｲ ｨｬ0401 ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ01 08ｨ 0405ｨｨ ﾂｨｪ0401 ｨｪｨ 0008ｨｮ04ｨｺｨ 01). 05ｨ ｨｰ02ｨｬ ｨｰ 0904 ﾂｨｨｨｰｨ ｨｪｨｨ02 ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨｨｦ, ﾂｨｰ06ｨ ｨｰｨ 09ｨｨｨｰｨｹ 05ｨｨ03ｨｹ ｨｰ02 ｨｮ ﾂｨ 09ｨｰｨｺｨｨ, 09 ｨｺ06ｨｰ ｨｰｨｬ02 ﾂｨ 06ｨｰ0907 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｮ05ｨｹｨｰｨ ｨｰ02 ｨｺｨ ｨｺ ｨｰ ｨｦ09ｨｰ09ｨｨ07 (ｨｪｨ 0708ｨｨｨｬ0208, ｨｺ0602 ｨｨ ｨｪｨ 0008ｨｮ04ｨｺｨｨ) ｨｬ06ｨｴｨｹ06 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ ｨｬ0603ｨｪ06 ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ080609ｨ ｨｰｨｹ ｨｨ 0802ｨｺ06ｨｪ09ｨｰ08ｨｮｨｨ080609ｨ ｨｰｨｹ ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨ07 05ｨｨ03ｨｹ ｨｰ ｨ 05ｨ 09ｨｰ02ｨｦ ｨｬ060400ｨ, 09 ｨｺ06ｨｰ ｨｨ05ｨｨ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ0402, 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ ｨ 0405ｨｨ ﾂｨｨ (Fox P.T. et al., 1988; Friston K.J. et al., 1991). 0308ｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨｨｨ 0905ｨｨ07ｨｪｨｨ07 08ｨ 0405ｨｨ ﾂｨｪ0401 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06ｨｪｨｪ ｨ ｨｪｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨｬ060400ｨ ｨｨ ｨｹ04ｨｮ06ｨｰ ｨｰｨ ｨｺ ｨｨ ｨ ｨｪｨｨ (Greenberg J.H. et al., 1981; Phelps M.E. et al., 1981; Fox P.T. et al., 1988) ｨｺ0605ｨｹｨｺｨｮ ｨｺ0604ｨ ｨｰ0907 ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺ06ｨｬ ｨ % , ｨｪ0206ｨ ｨｨｨｬ ｨ 0102ｨｺ09ｨ ｨｰｨｪ06ｨｦ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｺ0502ｨｰ06ｨｺ ｨｬ060400ｨ, ｨｨ ﾂｨｪ06 ｨ ｨｨｨｰｨｹ, ﾂｨｰ ｨｪｨｨ02 ｨｪｨ ｨｺ ｨｪｨｨ , 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｴ ｨ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨｨｨ , ｨ ｨｮ0102ｨｰ ｨｨ ｨｨｨｰｨｹ ｨｮ06 06 ﾂ ｨｹ 09 ｨｰ ｨ 05ｨ 09ｨｰ0701 ｨｬ060400ｨ, ｨｺ06ｨｰ ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ06ｨｰ ｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨｨ07ｨｪｨｨ02ｨｬ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｪｨ 0008ｨｮ04ｨｺｨｨ ｨｰ ﾂｨｰ06ｨ 04 ｨ ｨｰ06 ﾂｨｪ ｨｪｨｨｨｰｨｹ 01ｨｨｨｪｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｺｨ 04ｨ ｨｰ020502ｨｦ ｨｪｨｪ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ ｨｬ060400ｨ, ｨｪｨ 0708ｨｨｨｬ ｨｨ ｨｰ0608ｨｪ ｨｨ ｨ ｨｪｨｨ ｨｨ ﾂ02ｨｪｨｨ07, ｨ ｨｰｨ ｨｺ0302 ﾂｨｰ06ｨ 04 ｨｮｨｰ06 ﾂｨｪｨｨｨｰｨｹ 0506ｨｺｨ 05ｨｨ04ｨ 02ｨｨ06 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨｰｨｪ060302ｨｪｨｨ06 ｨｺ ｨｺｨ ｨｺ06ｨｬｨｮ-ｨｰ06 ｨｺ06ｨｪｨｺ0802ｨｰｨｪ06ｨｬｨｮ ｨ ｨｪｨ ｨｰ06ｨｬｨｨ ﾂ0209ｨｺ06ｨｬｨｮ 06ｨ 08ｨ ｨ ｨｪｨｨ06, ｨ 0405ｨｨ ｨｪ04 08ｨ 0405ｨｨ ﾂｨｪ0402 ｨｬ02ｨｰ ｨｨ09ｨｰ08ｨ 02ｨｨｨｨ ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨｨｦ , 0908ｨ 09ｨｪ02ｨｪｨｨ07 ｨｨ01 ｨｬ020301ｨｮ 0906ｨ 06ｨｦ ｨｨ 09 ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨ07ｨｬｨｨ, ｨｮ ﾂ02ｨｪｨｪ04ｨｬｨｨ ｨｬ06ｨｴｨｹ ｨｮ00ｨｨ01 ｨｰ06ｨｬ060008ｨ 00ｨｨ ﾂ0209ｨｺｨｨ01 ｨｬ02ｨｰ , ｨｰｨ ｨｺｨｨ01, ｨｺｨ ｨｺ ｨｨ05ｨｨ ｨｰｨ ｨｺ06ｨｦ ｨｨ09ｨｰ08ｨ 02ｨｨｨｨ 09ｨｪ0609ｨｹ ｨｮ ﾂ02ｨｪｨｪ ｨｨ , ｨｨ/ｨｨ05ｨｨ ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｰ 0108ｨｮ ｨｮ00ｨｮ, ｨｰ ｨｰｨｹ ｨｪｨ ｨｰ0907 ｨｪｨ 0601ｨｪ06ｨｬ ｨｮ080609ｨｪ ｨｬ0603ｨｪ06 ｨｰｨ ｨｺ ｨｬ02ｨｴ02ｨｪｨｨ02, ｨｰ ｨｰｨｹ 00ｨｪｨ ｨｪｨｨ0203 ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨｨｦ 0108ｨｮ00 ｨｪｨ 0108ｨｮ00ｨ. 00ｨｪ0600ｨｨ ｨ ｨｨ09ｨｰ08ｨ 02ｨｨｨｨ ｨｨ ｨｬ02ｨｴ02ｨｪｨｨ07 ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨｨｦ ｨ 0405ｨｨ ｨｪ04 ｨｪｨ ｨｬ ｨｨ 09 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ ｨ ｨｪｨｨ0701 (Pietrzyk U. et al., 1994; Nelson S.J. et al., 1997; West J. et al., 1997; Woods R.P. et al., 1998; Vlassenko A.G. et al., 2000a,b). 00 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｪｨｰ ｨｨｨｬ0206ｨｰ ｨ ｨｬｨｬｨｪ ｨ ﾂ02ｨｪｨｨ02, ｨｴ ｨｮｨｴ0209ｨｰ090507ｨｰｨｹ ｨｨ09ｨｰ08ｨ 02ｨｨ06 ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨｨｦ. 0201ｨｪｨｨｨｬ ｨｨ ｨｪｨｨ ｨｰｨｨ0302ｨｪｨｨｨｦ 09 05ｨｰ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ ｨｰ ｨ 0408ｨ ｨ 06ｨｰｨｺｨ ｨｺ06ｨｬｨ ｨｨｨｪｨｨ080609ｨ ｨｪｨｪ /0806-ｨｮ09ｨｰｨ ｨｪ060906ｨｺ, ｨｴｨｨ ｨｨｨｰｨｹ 06ｨ ｨ ｨｨ ｨ ｨｪｨｨ07 ｨ 0204 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｪｨｨ07 ｨ 0605ｨｹｨｪ ｨｨ ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ ｨｮ ﾂｨ ｨｰｨｹ ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ ｨｮ ｨｮ00ｨｮ ｨｨ 0806-ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨ07 (Beyer T. et al., 2000) ｨｬ0603ｨｪ0609ｨｰｨｨ ﾂ02ｨｪｨｹ ｨｨｨｺｨｨ ｨｨ ｨｺｨｰｨｨ ﾂｨｰｨｨ ｨ ｨ ｨｪｨｨ ﾂｨｪ ｨｰ06ｨｬ 06ｨ ｨｬ ｨｰｨ 09ｨｨ05ｨｨ 05ｨｨ03ｨｹ ｨｺ08ｨ ｨｰｨｺｨｮ06 ｨｨｨｪ000608ｨｬｨ 02ｨｨ ｨｨｨｪ02ｨｨ07ｨ ｨｮ ﾂ02ｨｪｨｨ07 ｨｨ0406ｨ 08ｨ 0302ｨｪｨｨ07, 0609ｨｪ0609ｨｪ0401 ｨｨ0406ｨｰ0607ｨ 01, ｨｨ ｨｺ0605ｨｨ ﾂ0209ｨｰ0902ｨｪｨｪ ｨ 08ｨ ｨｬ02ｨｰ08ｨ 01, ｨ ｨｰｨ ｨｺ0302 ｨｪ02ｨｺ06ｨｰ ｨ ｨｪｨｪ ｨｪ0608ｨｬｨ 05ｨｹｨｪ06ｨｦ 00ｨｨ04ｨｨ ｨｨｨｨ ｨｪ ｨｬ ﾁ ﾁ ｨC 01 2 (28) ｨC III/IV 2002

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Tomogr., 22: 139ｨC ｧｱｧｰｧｩｧｪｧｴｧｲｧｰｧｯｧｯｧ 'ｧｦｧｮ0ﾑ9ｧｳ0ﾑ9ｧｫｧｯｧ 'ｧｴｧｰｧｮｧｰｧ ｧｲｧ ｧｶ0ﾑ9ｧﾁ ｧ ｧｰｧｭｧｰｧ ｧｯｧｰｧ ｧｰ'ｧｮｧｰｧｩｧｬｧｵ:'ｧｰｧｳｧｯｧｰｧ ｧｯ0ﾑ9 ｧｱｧｲｧｪｧｯｧｸｧｪｧｱｧｪ'0ﾑ9'ｧｩｧ ｧｳｧｴｧｰｧｳｧｵｧ ｧ ｧｯｧｯｧﾁ'ｧｵ'ｧｭｧﾀｧ ｧｪｧｯｧｪ ｨ 0902ｨｪｨｺ06, ｨ ｨｺ020209, ｨｪｨｰ06ｨｪ ｨｬ ｨｨｨｰ0806ｨｪｨｪｨ 02ｨｬ060906ｨｦｨｪｨ ｨｰ06ｨｬ060008ｨ (030306) ｨｮ ｨ 0605ｨｹ ｨｨ04ｨｪｨ ｨｪｨｪ07 ｨｮ ｨｺ0506ｨｪ06 ﾂｨｪ06ｨｦ 0708ｨ ｨｺｨｰｨｨ ｨ 09ｨｰ0609ｨｮ09ｨ ｨｪｨｪ07 ｨｺ060806ｨｰｨｺ0603ｨｨ09ｨｮ ﾂｨｨ ｨｰ ｨｨｨｰｨｨ ｨｰ0608ｨｪ ｨｪｨｪ07 ﾂ ｨｺ060806ｨｰｨｺ ｨｬ0603ｨｺｨｨ ﾂｨ 09ｨｮ 06 09ｨｨｨｺ0608ｨｨ09ｨｰ0609ｨｮ09ｨ ｨｰｨｨ ｨｪ06ｨｬｨ ｨｪ06ｨｰｨｪ06 00ｨｮｨｪｨｺ020606ｨｪｨ 05ｨｹｨｪ ｨ ｨｨ ｨｪｨ 01ｨ 02 ｨｮｨｪ06ｨｺｨ 05ｨｹｨｪｨｮ ｨｬ060305ｨｨ090609ｨｰｨｹ ｨｪ0206ｨｪ09ｨ 04ｨｨ09ｨｪ0607 ｨｺ0605ｨｹｨｺ0609ｨｪ ｨｪｨｺｨｨ ｨｬ0604ｨｺ ｨｬ0601ｨｨｨｪｨ ｨｬ06ｨｺｨｨ, 02ｨｪ ｨｰｨｨ ﾂｨｪ ｨ ｨｬ06ｨｪｨｮ ｨｬ0604ｨｺｨｮ, ｨ ｨｰｨ ｨｺ0603 ｨｦ ｨｰ ｨｰｨ ｨｪ02ｨｦ0806ｨｬ020106ｨ ｨｰ0608ｨｪｨｨ01 09ｨｨ09ｨｰ02ｨｬ ｨｪｨ ﾂｨｪ0606 ｨｬ ｨｨ0705ｨ ｨｺ06ｨｪｨ 0502ｨｪｨｪ06 04ｨｪｨ ｨｪｨｹ ｨｰｨ ｨｨｨｰｨｺｨｮ ｨｬ0607 ｨｬ0604ｨｺｨｮ, ｨ ｨｰｨ ｨｺ ｨｨ05ｨ 0607ｨｨ09ｨ ｨｰｨｨ ｨｰｨ ｨｺ06 09ｨ 0305ｨｨ ｨ ｨｰ ﾂｨｪ ｨｪ06ｨｬ02ｨｪｨｨ, 07ｨｺ 0004ｨ 0601ｨｪ02ｨｪｨ ｨｮ , ｨｬ06 ﾂｨｪｨ ｨｪｨ ｨｰ06ｨｪｨｹ03 ｨｰｨ ｨ 03ｨｨ ｨｨｨｺｨ ｨｺ0605ｨｹｨｺ0609ｨｰｨｹ 03ｨｨｨｰｨｰ ｨ 0305ｨｨ09ｨｨ01 00ｨｮｨｪｨｺ0206ｨｦ ｨｪ ｨｬ0604ｨｺｨｮ ｨ ｨｮ05ｨｨ 09ｨｨ09 ﾂ02ｨｪ06 04ｨ ｨｬ ｨｪ06ｨｬｨ ｨｪ06ｨｰｨｪｨｨｨｬｨｨ ｨｪｨｺ0609ｨｨｨｬｨｨ, 08ｨｮ010609ｨｨｨｬｨｨ ｨｰｨ ｨｺ0600ｨｪｨｨｨｰｨｨ09ｨｪｨｨｨｬｨｨ 00ｨｮｨｪｨｺ020606ｨｪｨ 05ｨｹｨｪｨｨｨｬｨｨ ｨｪｨ 09ｨ ｨｪｨｰｨ 0302ｨｪｨｪ07ｨｬｨｨ ﾂ ｨ : ｨｨｨｰ0806ｨｪｨｪｨ 02ｨｬ060906ｨｦｨｪｨ ｨｰ06ｨｬ060008ｨ , ｨｺ060806ｨｰｨｺ0603ｨｨ09ｨｮ ﾂ ｨｰ0607ｨｨ, 08ｨ ｨ 08ｨｬ ｨ 08ｨ ｨｰｨｨ, 00ｨｮｨｪｨｺ020606ｨｪｨ 05ｨｹｨｪ ｨ ｨｨ, 0004ｨ 0601ｨｪ02ｨｪｨ ｨｮ , ｨｬ06 ﾂｨｪｨ ｨｪｨ ｨｰ06ｨｪｨｹ03, ｨ 03ｨｨ0403. BRAIN'POSITRON'EMISSION TOMOGRAPHY:'BASIC'PRINCIPLES'AND APPLICATIONS'IN'HUMAN A.G. Vlassenko, S.S. Makeyev, M.A. Minton Summary. Positron emission tomography (PET) becomes more and more recognized diagnostic method in clinical practice. Relative short half-lives of PET isotopes allows repeated measurements in short time intervals, including functional activation studies. PET provides unique opportunity of non-invasive quantitative measurement of cerebral hemodynamics, brain energetic metabolism as well as receptor and neurotransmitter distribution. PET contributed significantly to understanding the stages of brain ischemia and description of some important pathophysiological phenomena such as 00misery perfusion03, ischemic penumbra03, and 00diaschisis03. Many important brain functions were assessed using PET with various behavioral, motor, and cognitive tasks. Key words: positron emission tomography, short-lived isotopes, radiopharmaceuticals, functional activation, misery perfusion, ischemic penumbra, diaschisis ｧ ｧﾕｧ筴ﾖｧ'ｧﾕｧﾝｧ'ｧ皎ﾖｧ筴ﾖｧ皎ﾚｧ綵ｧﾚ: 00ｨ ｨｺ ｨｦ ｨｨ ﾂ 04050, 08ｨｨ0209, ｨｮ05. 00ｨ ｨｪｨｮｨｨ05ｨｹ09ｨｺ060006, 32 06ｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｪ02ｨｦ080601ｨｨ08ｨｮ0800ｨｨｨｨ ｨｨｨｬ ｨｬ0601ｨ ｨｪ0609ｨ ｨｺ08ｨ ｨｨｨｪ04, 05ｨ ｨ 0608ｨ ｨｰ0608ｨｨ07 08ｨ 01ｨｨ06ｨｪｨｮｨｺ05ｨｨ01ｨｪ06ｨｦ 01ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨｨ ﾁ ﾁ ｨC 01 2 (28) ｨC III/IV 2002