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- かおり くぬぎ
- 7 years ago
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Transcription
1
2
3 =7y/> *-z r f -t V)t /ttv 2mg t-z rf,t Y)t/ttv 5mg t-7 rf -t Y)t7ttv l}mg
4 NTBC2mg NTBC5mg NTBClOmg
5 Cmax (uelml) rt,z
6
7
8 Boehringer Ingelheim
9
10 5ng n=6 ttzz s rhl
11 CLn ezl ImLlnin]
12 ,l5ue(n=70)
13
14
15 Page 1
16 Page2
17 Page 3 AUCsasp (oo. hrlml-) tttz ftr) Xn-4 lvz (hr)
18 Page 4 x:u:6il
19 Page 5
20
21
22
23
24 Trz (h)
25 p<0 000f' -2 3Yol ?q o. rz4okl'
26
27
28
29
30
31 (mean*sd. n=12)
32
33
34
35
36 34.5 mg
37
38 CL (ml,/midkg) trn (min)
39
40
41 l6 1ms ll I nrq )--< 2 ::- l. - 1y o 17 ilrq
42 itif fllf f
43
44
45
46
47
48
49
50
51
52 tb NovARr I s
53 trfl4^/l^7
54 Cmax (uglml)
55 300m9 I 50mg I 5omg 75nC tlogisticelb (60t181fl\ 3E/62$l 15mg 300mg 75mg 300ng I 5Omg 15mg
56 3inaruho vltrfifft=ta?t
57 tlr NovnRr I s
58 trb+^/l^7,
59 Cmar (ug/ml)
60 l5omg 75mE 300m9 300mg I 5omg l5omg 75mg 75mg t289/3t2lf'l\
61 tlttl: E-*9:(xFl7:3() (frbeuetriern<) w\,\rw. novartis.co.jp inaruho vlt,fi#frrte?t
62
63
64
65
66
67 PtviFTzffiz+omg
68 Grade 4
69
70
71 c.- Lti2 I pg/nl) (h)
72 - <^,'r=^ rrtu,1tta -flrffi I 16@ll frll\t>r M 2S l fl I I ^Laa'=1* M 3n 26 ua t62 lll & $ 14 6 I A4Fffi H (OS) O Kaplan-Meierffi fr (2010+I2E30E h v lt7)
73
14 12 10 8 6 4 2 0 1 2 3 4 5 6 7 8 9 10 11 12 20 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 22 0 0 0 0 0 0 0 0 0 0 0 0 23 0 0 0 0 0 0 0 0 0 0 0 0 24 0 0 0 0 0 0 0 0 0 0 0 0 25 0 0 0 0 0 0 0 0 0
Page 1
Page 1 Page 2 Page 3 Page 4 620 628 579-41 -6.7-49 -7.9 71 41 47-24 -33.3 6 15.9 11.5 6.5 8.1 36 15 22-14 -38.9 7 43.4 Page 5 277 302 23 24 12/3Q 12/4Q 13/1Q 13/2Q 13/3Q 13/4Q 14/1Q 14/2Q 14/3Q 14/4Q 15/1Q
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Page 4/30 Page 5/30 Page 6/30 Page 7/30 Page 8/30 Page 9/30 Page 10/30 Page 11/30 Page 12/30 Page 13/30 Page 14/30 Page 15/30 Page 16/30 Page 17/30 Page 18/30 Page 19/30 Page 20/30 Page 21/30 Page 22/30
Microsoft Word - 表紙資料２－４
(1) / 130 g 25 g 520% 170 g 30 g 560% 70 mg 600 mg 11.6% 0 10.5 mg 0% (1) (2) / 50100 g 25 g 200400% 50100 g 30 g 167333% 5001000 mg 600 mg 83167% 1020 mg 10.5 mg 95190% (2) / (1) 45.6 g 30 g 152% (2)
2.
2. 10 2. 2. 1995/12006/111995/42006/12 2. 10 1995120061119954200612 02505 025 05 025 02505 0303 02505 250100 250 200 100200 5010050 100200 100 100 50100 100200 50100 10 75100100 0250512 02505 1 025051205
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41 42 73 121 121 10 122 11 122 12 131 13 131 15 10 133 16 11 133 17 12 136 18 13 141 19 14 141 20 15 146 21 16 149 22 17 149 23 174 18 24 73 19 241,301 25 20 242,301 (1) 26 21 331 27 22 241,341 28 23 242,341
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21.8 + + ø ø ø ø ø ø ø ø ø ++ + ++ + + + ± FH 28 D - 5S -.5 SH (5) 1 2 3 4 5 6 7 1 2 3 4 5 6 7 ** ** ** ** ** ** ** ** ** ** ** ** ** CL586-1861-4-** CL586-1868-3-** CL586-1823-5-** CL586-1835-4-** CL586-1827-6-**
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3- {a-[(^9)-2-hydroxy-3'(2-morpholirocarbonylamino) ethylaminolprnpoxy I phenylpropionate monohydrnchloride (!s/ml) a m El t) >1! 0 (mllmin) CR/F Cmax (rrolml) p=0.0008 4OOmg l5orngiln X li3oomg
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ISO14000 1191 14910 625mm 9mm 1500mm L5L50L95L10 L50L90 LED LED 30m 100m 22kg 40m/s 610mm 1LED 40m/s S L5L50L95L10L50L90 500S2000 523) () 1 2 3 4 136 12 12 12 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
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Japanese_SC Catalog_April2009.indd
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コロイド化学と界面化学
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P0681-P0758-›ºflÅŠpB5.qxd
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CH TC CL CF RoHS RoHS RoHS RoHS BP14 RoHS RA-Y RoHS RoHS RA RoHS RA-Y ( ) IP53 1000h 120h RoHS () 1 RA-Y 160mm IP53 b RA16-63Y 600 300 160 520 220 480 180 450 400 112 142 12.4 1 27,000 b RA16-64Y 400 320
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NPO () NPO -1 - 3 2-2 - 3 500m 3-1-1 500m 600m/s 500m 431 500m FDEL (1999) 500m (2003) 1km 500m 250m 500m (2002) 0.1% 3-1-1 15.7% 3-1-1 24.9% 3-1-2 1000 7.9 7.3 7.3 4 8.5 0.1% 7.25 0.1 7.2 15.7 7.0 10.8
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リザルト集約
Page 1/26 Page 2/26 Page 3/26 Page 4/26 Page 5/26 Page 6/26 Page 7/26 Page 8/26 Page 9/26 Page 10/26 Page 11/26 58 1 2 48 48 48 1 31 1 1 47 56 1 50 28 27 58 26 27 26 95 27 27 9 9 1 56 47 47 58 48 26 56
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85 4 86 Copright c 005 Kumanekosha 4.1 ( ) ( t ) t, t 4.1.1 t Step! (Step 1) (, 0) (Step ) ±V t (, t) I Check! P P V t π 54 t = 0 + V (, t) π θ : = θ : π ) θ = π ± sin ± cos t = 0 (, 0) = sin π V + t +V
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