Tsitologiya. 56 (11) : 789–799

Transcription

1 ｨｬ 56, , , , ｨ ｨｺ ｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｨ06ｨｪｨｪ06ｨｦ 00ｨｨ04ｨｨ ｨｨｨｨ ｨｨ ｨ ｨｨ0601ｨｨｨｬｨｨｨｨ ｨｨｨｬ ﾂ02ｨｪ0609ｨ , 05ｨ ｨｪｨｺｨｰ-0302ｨｰ0208ｨ ｨｮ0800, ｨ ｨｺ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ, ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ, ｨｨ ｨｰｨｨｨｪ06ｨｬ 0201ｨｪｨｨｨｬ ｨｨ04 09ｨ 03ｨｪ02ｨｦ03ｨｨ01 00ｨ ｨｺｨｰ , ｨｮｨｴｨｨ01 ｨｺ 08ｨ 0409ｨｨｨｰｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ 09ｨ 01ｨ 08ｨｪ ｨｨｨ ｨ 02ｨｰｨ ｨｰｨｨ07ｨ (05022), ｨｰ0907 ｨｪｨ 08ｨｮ0302ｨｪｨｨ ｨｬ06ｨｪｨ 05ｨｹｨｪ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬｨ 01 ｨｬ060400ｨ, ｨｮ05ｨｨ08ｨｮ02ｨｬ0401 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ, ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨ ｨｪ04ｨｬ 00ｨ ｨｺｨｰ060806ｨｬ ｨｰｨ -1 ( ) ｨｨ ｨｰｨｨｨｪ06ｨｬ. 0308ｨｨ ﾂｨｨｨｪｨ ｨｬｨｨ 05ｨｰｨｨ01 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｰ0907 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ ｨ ｨ 05ｨ ｨｪ09ｨ ｨｨ 05ｨｨ07ｨｨ01ｨｪ ｨ ｨｬ02ｨｪｨ, ｨｮｨｴｨｨ02 ｨｺ 05ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ ｨｨ 09ｨｰ ｨｮ 05ｨｪ ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ ｨｰｨｨｨｺｨｮ05ｨｮｨｬｨ 09 ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01, ｨ ｨｰｨ ｨｺ ｨｨ0900ｨｮｨｪｨｺ02ｨｨｨｨ 09 ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨｪ ｨｨ09ｨｰ02ｨｬｨ 01 ｨｬ060400ｨ, 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ ｨｪｨｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ, ｨｨ ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ04ｨｬｨｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｬｨｨ ｨｪｨｰｨｨ00ｨｨｨｺｨ 02ｨｨ07 ｨｬ060502ｨｺｨｮ050708ｨｪ0401 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ 09 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ, ｨｨ ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ09ｨｰ02ｨｬｨ 01 ｨｬ060400ｨ 09 ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｨ ｨｹ040609ｨ ｨｪｨ ｨ ｨｪｨｪ02ｨｦ 01ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨｨ 05ｨｰｨｨ01 04ｨ ｨ ｨ ｨｪｨｨｨｦ, ｨ ｨｰｨ ｨｺ ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ ｨｪ ｨｰ08ｨ ｨｰ0200ｨｨｨｦ ｨｪｨｰｨｨ09ｨｪ ﾂ02ｨｪｨｨ ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨ ｨ ｨｪｨ 05ｨｨ04ｨｨ080609ｨ ｨｪ04 01ｨ ｨｪｨｪ ｨｨｨｰ0208ｨ ｨｰｨｮ0804 ｨｨ ｨｮ05ｨｹｨｰｨ ｨｰ ｨ 09ｨｰ0902ｨｪｨｪ0401 ｨｨ ｨ ｨｪｨｨｨｦ, ｨｺｨ 09ｨ 06ｨｴｨｨ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ 09 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ, ｨｨ ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬｨ 01 ｨｬ060400ｨ 09 ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｨ ｨｨ ｨｨ 09 05ｨｰｨｨ ｨｨｨｨ ｨｨ 07ｨ ｨｰ060002ｨｪ , ｨ ｨｰｨ ｨｺ ｨ 09ｨｮ0301ｨ 06ｨｰ , ｨｪｨ 0708ｨ ｨｪｨｪ0402 ｨｪｨ ｨｰｨ ｨｪ ｨｪｨｨ02 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 05ｨｰｨｨ01 09ｨｨ09ｨｰ02ｨｬ ﾂ ｨ : 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09, ｨｨｨｪ09ｨｮ05ｨｨｨｪ, ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨ ｨｪ04ｨｦ 00ｨ ｨｺｨｰ ｨｰｨ -1, ｨｰｨｨｨｪ, ｨｬ060400, ｨｰ0608 ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ, 09ｨ 01ｨ 08ｨｪ04ｨｦ 01ｨｨｨ ｨ 02ｨｰ. 0308ｨｨｨｪ07ｨｰ ｨｺ08ｨ ｨｴ02ｨｪｨｨ07: 0604 ｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060904ｨｦ ｨｰ0608, ｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨ ｨｪ04ｨｦ 00ｨ ｨｺｨｰ ｨｰｨ -1, ｪ ｨｰ0608 ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨ ｨｪ ｨ ｨｺｨｰ0608ｨ ｨｰｨ -1, ｪ ｨ 06ｨｴｨｨｨｦ ｨ ｨｺ, ｪ ｨｬ0205ｨ ｨｪ0602ｨｨｨｰ09ｨｰｨｨｨｬｨｮ05ｨｨ08ｨｮ06ｨｴｨｨｨｦ ｨｬ06ｨｪ, ｪ 09ｨ 01ｨ 08ｨｪ04ｨｦ 01ｨｨｨ ｨ 02ｨｰ ｨｰｨｨ07ｨ, ｪ 09ｨｰ ｨｪ ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ ｨｰｨｨｨｺｨｮ05ｨｮｨｬｨ, IRS1 ｨｨ IRS2 ｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｰ0608ｨｪ ｨｮｨ 09ｨｰ08ｨ ｨｰ ｨｨ ｨｰｨｨ070609, PI3K ｪ ｨ ｨｰｨｨ01ｨｨ05ｨｨｨｪ0604ｨｨｨｰ ｨｺｨｨｨｪｨ 04ｨ. 00 ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ07 09 ｨｬｨｨ0802 ｨｪ02 ｨｬ02ｨｪ ｪ40 % ｨｪｨ ｨｪｨｨ07 ｨｨｨｬ0206ｨｰ ｨｨ04ｨ 04ｨｰ06 ﾂｨｪｨｮ06 ｨｬｨ 0909ｨｮ ｨｰ0205ｨ ｨｨ 0108ｨｮ00ｨｨ02 ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ02 08ｨ 0909ｨｰ0806ｨｦ09ｨｰ09ｨ. 0308ｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ ｨ 0102ｨｺ09ｨ ｨｰｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ 06ｨｪｨｨ 09ｨｪｨ ﾂｨ 05ｨ ｨｰ 09 09ｨｰｨ 01ｨｨ ｨｨｨ ｨ 02ｨｰｨ, ｨｺ06ｨｰ ｨ 08ｨ ｨｺｨｰ0208ｨｪ06 09ｨｪｨｨ0302ｨｪｨｨ02 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｰｨｺｨ ｨｪ02ｨｦ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ, ｨｨ 01ｨ , 0708ｨｨ ｨｪ02ｨ 05ｨ ｨｨ07ｨｰｨｪ06ｨｬ ｨｪｨ 08ｨｨｨｨ, ｨｪ04ｨｦ 09ｨ 01ｨ 08ｨｪ04ｨｦ 01ｨｨｨ ｨ 02ｨｰ ｨｰｨｨ07ｨ (05022), ｨｺ06ｨｰ060804ｨｦ 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ02ｨｰ ｨｨ0806ｨｺｨｨｨｬ ｨｺｨｰ0806ｨｬ ｨｪ02ｨｪｨｨｨｦ ｨｰ060806ｨｪ ﾂｨｪ ｨｮ01ｨｨ09ｨｰ06ｨｦ, ｨｨｨｰ0205ｨｹｨｪ06ｨｦ, ｨｪ020809ｨｪ06ｨｦ, 05ｨｪ0106ｨｺ08ｨｨｨｪｨｪ06ｨｦ ｨｨ 0108ｨｮ00ｨｨ01 09ｨｨ09ｨｰ02ｨｬ ｨ ｨｪｨｨ04ｨｬｨ. 0201ｨｪｨｨｨｬ ｨｨ ｨｺｨｰｨｨ09ｨｪ0401 ｨｨ ｨｬｨｪ ｨ 02ｨｴｨ 06ｨｴｨｨ ｨｰ0908ｨ ｨｴ02ｨｪｨｨ07 08ｨ 0409ｨｨｨｰｨｨ ｨｪ ｨｰ ｨｪｨｰｨｨ09ｨｪ ﾂ02ｨｪｨｨ02 ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ 08ｨ ｨｪｨｪ , ｨｺ060001ｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ ｨ ｨｪｨｨ04ｨｬ02, ｨ ｨｪｨｪ0402 ｨｪｨ 08ｨ 09ｨｰｨ 06ｨｴ02ｨｦ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ06, 01ｨｨ0905ｨｨ07ｨｨ0102ｨｬｨｨ02ｨｦ ｨｨ 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ04ｨｬ 09ｨｰ ｨｬ, 02ｨｴ02 06ｨ 08ｨ ｨｰｨｨｨｬ ｨｰ ｨｬ ｨｨ ｨｪ0609ｨｪ ｨｪｨｨｨｬｨ ｨｪｨｨ02 ｨｮ ｨｰ 0502 ﾂ02ｨｪｨｨ06 ｨｮ ｨ 0409ｨｨ ｨ ｨ ｨ ｨｪｨｨ07, ｨｺ06ｨｰ ｨ 08ｨ ｨｺｨｰ0208ｨｪｨ ｨｰ ｨ 07 09ｨｨｨｬ07ｨｰ06ｨｬｨ ｨｰｨｨｨｺｨ. 0308ｨｨ 05ｨｰ06ｨｬ ｨｺ ｨｺ02ｨｨｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ, ｨｪｨｨｨｺｨ 06ｨｴｨｨ01 ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ 08ｨ ｨｪｨｪ , 06ｨ 04 ﾂｨｪ06 ｨｪ02 ｨｮ ｨｰ ｨｪ ｨｪｨｨｨｬｨ ｨｪｨｨ07. 02ｨ ｨｴ020708ｨｨｨｪ07ｨｰ06ｨｦ ｨｰ0907 ｨｰ06 ﾂｨｺｨ ｨｪｨｨ07 06 ｨｰ06ｨｬ, ﾂｨｰ ｨｴｨｮ ｨｹ 09 05ｨｰｨｨ ｨｨｨｨ ｨｨ 07ｨ ｨｰ060002ｨｪ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｨ0008ｨ 06ｨｰ ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609ｨ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ, 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ04ｨｦ 09ｨｰ , 01ｨｨ0905ｨｨ07ｨｨ0102ｨｬｨｨ07, 05ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ. 0201ｨｪｨ ｨｺ ｨｪｨｨ ｨｪｨ ｨｺｨ 0705ｨｨ09ｨ 02ｨｰ ｨ 0605ｨｹ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09 ｨｰ060006, ﾂｨｰ06 09ｨ 03ｨｪｨｮ ｨｹ ｨｹ ｨｨ0008ｨ 06ｨｰ ｨｬ06ｨｪｨ 05ｨｹｨｪ ｨ ｨｺｨｰ (Shpakov, Derkach, 2013) ｨｺ0605ｨｹｨｺｨｮ ｨｪｨ 08ｨｮ0302ｨｪｨｨ ｨｬ06ｨｪｨ 05ｨｹｨｪ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬｨ ｨｰ0907 ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ 08ｨ ｨｪｨｪ , ｨｨ01 ｨｺ ｨｺ02ｨｨ06 ｨｬ0603ｨｪ06 08ｨ 0909ｨｬｨ ｨｰ08ｨｨ09ｨ ｨｰｨｹ ｨｺｨ ｨｺ 0601ｨｨｨｪ ｨｨ04 07ｨｮｨｰ02ｨｦ ｨｪｨｰｨｨ09ｨｪ ﾂ02ｨｪｨｨ07 ｨｨ ｨｨ05ｨ ｨｺｨｰｨｨｨｺｨｨ ｨｪ06ｨｦ ｨｬ ｨｰ06 06ｨｰｨｪ0609ｨｨｨｰ0907 ｨｺ ｨｬ06ｨｪｨ 05ｨｹｨｪ04ｨｬ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ04ｨｬ 09ｨｨ09ｨｰ02ｨｬｨ ｨｬ ｨｬ060400ｨ, ｨｺ06ｨｰ ｨｮ05ｨｨ08ｨｮ06ｨｰ0907 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ ｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨ ｨｪ04ｨｬ 00ｨ ｨｺｨｰ060806ｨｬ ｨｰｨ -1 ( ), ｨｰｨｨｨｪ06ｨｬ, ｨｪ02ｨｦ ｨｰｨｨ01ｨ ｨｬｨｨ, ｨｬ06ｨｪ06ｨ ｨｬｨｨｨｪｨ ｨｬｨｨ ｨｨ ｨｪ02ｨｦ0806ｨｰ080600ｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ 00ｨ ｨｺｨｰ0608ｨ ｨｬｨｨ (Cole et al., 2007; de la Monte, 2009; de la Monte et al., 2010; Shpakov et al., 2011; Shpakov, 2012) ﾂ0209ｨｮ ｨｹ ｨｹ ｨｨ0008ｨ 06ｨｰ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｬ06ｨｪｨ 05ｨｹｨｪ06ｨｬ 09ｨｰｨ ｨｰｨｮ ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09ｨ, 09ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ04 ｨｺ06ｨｰ ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ ｨｮ050702ｨｨｨｨ ｨｦ ｨｬ06ｨｪｨ 05ｨｹｨｪ06ｨｦ 0902ｨｰｨｨ ｨｬ060400ｨ ｨｨ ﾂ ｨｪ ﾂ02ｨｪ04 09 ｨｺ06ｨｪｨｰ080605ｨｹ ｨｮ ｨｪ ｨｨ 03ｨｨ ｨ ｨｬ02ｨｪ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｪｨ 01 ｨｨ ｨｰｨｺｨ ｨｪ0701 (Obici et al., 2002b; Gelling et al., 2006; Morton, 2007; Purkayastha et al., 2011; Meek, Morton, 2012; Abraham et al., 2013). 01ｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｬ06ｨｪｨ 05ｨｹｨｪ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ 06ｨ ｨｮ ｨｪ04 ｨｬｨｪ0600ｨｨｨｬｨｨ 0708ｨｨ- ﾂｨｨｨｪｨ ｨｬｨｨ, ｨｨ ｨｺ06ｨｰ ｨｪｨｨ0302ｨｪｨｨ02 ｨｮ080609ｨｪ ｨｬ06ｨｪ0609 ｨｨ ｨｪ02ｨｦ- 789

2 ｨ ｨｺ ｨｬ0201ｨｨｨ ｨｰ , ｨｪｨ 08ｨｮ0302ｨｪｨｨ02 ｨｨ01 ｨｰ08ｨ ｨｪ ｨｰｨ ｨｨ ｨｨｨｪ00ｨ 09 ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01, ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ02 05ｨｺ ｨｨｨｨ ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨ 0205ｨｺ0609 ｪ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ ｨｰｨｨ01 09ｨｨ09ｨｰ02ｨｬ ｨｪｨｨｨｺｨｪｨｮ ｨｪ06ｨｬ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｬ ｨｺｨ 09ｨｺｨ 0102, ｨｰｨ ｨｺｨｨ02 ｨｪｨ 08ｨｮ0302ｨｪｨｨ ｨ ｨｰ0409ｨ 06ｨｰ ｨｰｨｹ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ, ﾂｨｰ ｨｰ ｨｺ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｪｨｰ08ｨ 05ｨｹｨｪ06ｨｦ ｨｮ050702ｨｨｨｨ 00ｨｮｨｪｨｺ02ｨｨｨｦ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｰｨｺｨ ｨｪ02ｨｦ, 09ｨｪｨｨ0302ｨｪｨｨ06 ｨｨ01 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ ｨｨ 0108ｨｮ00ｨｨｨｬ ｨｬ06ｨｪｨ ｨｬ, ｨｬｨｨ080609ｨ ｨｪｨｨ ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺ ｨｨｨｬ07ｨｰ06ｨｬ06ｨｺ06ｨｬ070502ｨｺ09ｨ (Shpakov, 2012) ｨｬ02ｨｪｨｪ0602, ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ ｨｨｨ ｨ 02ｨｰｨ, ｨｰｨ ｨｪ ｨｪｨｨ02 00ｨｮｨｪｨｺ02ｨｨｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ ｨ ｨｪ06 ｨｪ0608ｨｬｨ 05ｨｨ040609ｨ ｨｰｨｹ 0202ｨｪｨｰ08ｨ 05ｨｹｨｪｨｮ ｨｮ050702ｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ ｨｨ ｨｰ0908ｨ ｨｰｨｨｨｰｨｹ ｨｨｨ ｨ 02ｨｰｨ ｨｪ04ｨｦ ｨｪｨ ｨｺ ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ ｨｺｨｰｨｨ09ｨｪ , ｨｴｨｨ ｨｰｨ ｨｪ0609ｨｨｨｰｨｹ 0202ｨｪｨｰ08ｨ 05ｨｹｨｪｨｮ ｨｮ050702ｨｨ06 ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ ｨｨｨ ｨ 02ｨｰｨ, ｨｪ0206ｨ ｨｨｨｬ06 ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ080609ｨ ｨｰｨｹ ｨｪｨ 08ｨｮ0302ｨｪｨｨ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬｨ 01 ｨｬ060400ｨ, ｨｪｨｨｨｺｨ 06ｨｴｨｨ02 ｨｪｨ 08ｨ ｨｪｨｪｨｨ01 09ｨｰｨ 01ｨｨ ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 07ｨ ｨｰ ｨｨｨｨ, ｨ ｨｰｨ ｨｺ ｨｪｨｨｨｰｨｹ ｨｬ060502ｨｺｨｮ050708ｨｪ ｨｨ ﾂｨｨｨｪ04 ｨｨ 07ｨ ｨｰ060002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｰ09ｨｨ07 ｨｰｨ ｨｺｨｨ01 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ. 01ｨ ｨｨｨ 0605ｨｹ03ｨｨｨｦ ｨｨｨｪｨｰ ｨｰ06ｨｬ 06ｨｰｨｪ060302ｨｪｨｨｨｨ ｨｰｨ ｨｰ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ, ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ, ｨｨ ｨｰｨｨｨｪ06ｨｬ, ｨｺ06ｨｰ ｨｨ0008ｨ 06ｨｰ ｨｨ09ｨｺ0506 ﾂｨｨｨｰ0205ｨｹｨｪ06 09ｨ 03ｨｪｨｮ ｨｹ 09 ｨｺ06ｨｪｨｰ ｨｪ0106ｨｺ08ｨｨｨｪｨｪ06ｨｦ, ｨｪ020809ｨｪ06ｨｦ, ﾂｨｪ ｨｮ01ｨｨ09ｨｰ06ｨｦ ｨｨ 0108ｨｮ00ｨｨ01 09ｨｨ09ｨｰ02ｨｬ ｨ ｨｪｨｨ04ｨｬｨ, ｨｮ050702ｨｨｨｨ ｨｮ ｨｪ ｨｨ 05ｨｨ07ｨｨ01ｨｪ ｨ ｨｬ02ｨｪ0609, 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ06ｨｦ ｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ. 08ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｬｨｮ ｨｰ0607ｨｪｨｨ06 05ｨｰｨｨ01 09ｨｨ09ｨｰ02ｨｬ ｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬ 09 ｨｪｨｨ01 ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｨ ｨ ｨｮ0102ｨｰ ｨｴ02ｨｪ ｨｪｨ 09ｨｰ0607ｨｴｨｨｨｦ 06ｨ ｨｨ ﾂｨｨｨｪ04 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｬ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｮ050702ｨｨｨｨ 09 ｨｬ ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 07ｨ ｨｰ ｨｨｨｨ 0308ｨｨ ﾂｨｨｨｪ04, ｨｺ06ｨｰ ｨｮｨｰ ｨｺ ｨｪｨ 08ｨｮ0302ｨｪｨｨ06 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ, ｨｮ05ｨｨ08ｨｮ02ｨｬ0401 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ, ｨｨ ｨｰｨｨｨｪ06ｨｬ, ｨｮ ｨｪ06 ｨｬ0603ｨｪ06 08ｨ ｨｨｨｰｨｹ ｨｪｨ ｨｮ ｨ 07 ｨｨ04 ｨｪｨｨ01 09ｨｺ0506 ﾂｨ 02ｨｰ ｨ 07 ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ02 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07, 01ｨｨ0905ｨｨ07ｨｨ0102ｨｬｨｨ06 ｨｨ 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ04ｨｦ 09ｨｰ , ｨｴｨｨ ｨｰ09ｨｨ02ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｨ 00ｨｨ ｨｨｨｺ02ｨｬｨｨｨｨ, 09 ｨｰ ｨｬ07 ｨｺｨ ｨｺ 09ｨｰ0608ｨ ｨ ｨｪｨ 09 ｨｪｨ 08ｨｮ0302ｨｪｨｨ02ｨｬ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨｨ080609ｨ ｨｪｨｨ07 ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨｪ ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ, ｨｮ05ｨｨ08ｨｮ02ｨｬ0401 ｨｬ06ｨｪ06ｨ ｨｬｨｨｨｪｨ ｨｬｨｨ ｨｨ ｨｪ02ｨｦ ｨｰｨｨ01ｨ ｨｬｨｨ, ｨｺ06ｨｰ ﾂ02ｨｪ04 09 ｨｺ06ｨｪｨｰ080605ｨｹ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ, ｨｨ ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ. 01ｨ ｨｨｨ 0605ｨｹ ｨｪｨ ﾂ02ｨｪｨｨ02 ｨｨｨｬ0206ｨｰ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 ｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07, ｨｪｨｨｨｺｨ 06ｨｴｨｨ ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪｨ 01, ｨｺ06ｨｰ ｨｨ0008ｨ 06ｨｰ ｨｺ0506 ﾂ0209ｨｮ ｨｹ 09 ｨｨｨｪｨｰ020008ｨｨ080609ｨ ｨｪｨｨｨｨ 09ｨｨ00ｨｪｨ ｨｨ 06ｨ ﾂ02ｨｪｨｨｨｨ 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ07 ｨｬ020301ｨｮ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ06ｨｦ 0902ｨｰｨｹ06 ｨｬ060400ｨ ｨｨ 09ｨｨ00ｨｪｨ 05ｨ ｨｬｨｨ, ｨｰｨｮ07ｨ 06ｨｴｨｨｨｬｨｨ ｨｨ000208ｨｨｨｨ (Sahu, 2011; Williams et al., 2011). 0201ｨｪｨｨｨｬ ｨｨ04 09ｨ 03ｨｪ02ｨｦ03ｨｨ01 00ｨ ｨｺｨｰ , ｨ 06ｨｴｨｨ01 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪｨ ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022, ｨｰ0907 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 05ｨｨ07ｨｨ01ｨｪ ｨ ｨｬ02ｨｪｨ (Martinez de Morentin et al., 2010). 06ｨｺｨｰ0607ｨｨ ﾂ0209ｨｺ0602 ｨｪｨ ｨｺ ｨｪｨｨ02 05ｨｨ07ｨｨ b-ｨｺ0502ｨｰｨｺｨ ｨｮ0106 ﾂｨｪ06ｨｦ , 0702 ﾂ02ｨｪｨｨ, , 09ｨｺ020502ｨｰｨｪ0401 ｨｬ040302ｨ 01, 0706 ﾂｨｺｨ 01 ｨｨ 0108ｨｮ00ｨｨ ｨ ｨｪｨ ｨｮ ｨｨ ｨｨ0802ｨｪｨｨ07 ｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺ ｨｨｨｪ010806ｨｬｨ ｨｰ ｨｺ 05ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ, ﾂｨｰ ｨ 05ｨｹｨｪ02ｨｦ0302ｨｬ ｨ 02ｨｰ 09ｨｨ05ｨｹｨｪ ｨ 0302ｨｪｨｪｨｮ06 ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609ｨｮ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ, ｨ ｨｰ ｨｪｨｪｨｮ06 01ｨｨ0905ｨｨ07ｨｨ0102ｨｬｨｨ06 ｨｨ 00ｨｨ070208ｨｨｨｪ09ｨｮ05ｨｨｨｪ02ｨｬｨｨ ｨｺ06ｨｪ02 ﾂｨｪ06ｨｬ ｨｨｨｰ060002, 05ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ ｨｰ0907 ｨｰ08ｨｨ ｨｬ ｨｨｨ ｨ 02ｨｰｨ, 0709ｨｪ ｨｨ ｨｪ02ｨｪｨｨｨｦ ｪ ﾂｨｪ ｨｮ01ｨｨ09ｨｰ ｨ ｨ ｨ ｨｪｨｨｨｦ, 03ｨｨ ｨｦ 01ｨｨ09ｨｰ080600ｨｨｨｨ 0702 ﾂ02ｨｪｨｨ ｨｨ 01ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｪ ｨ ｨｰｨｨｨｨ. 08ｨｮｨｪｨｺ02ｨｨ06 04ｨ ｨｴｨｨｨｰ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｰｨｺｨ ｨｪ02ｨｦ 06ｨｰ 05ｨｺｨｰ0607ｨｨ- ﾂ0209ｨｺ ｨｪｨ ｨｺ ｨｪｨｨ07 05ｨｨ07ｨｨ ｨｪ0706ｨｰ ｨｰｨｨｨｪ ｨｨ 0108ｨｮ00ｨｨ02 ｨ 01ｨｨ0706ｨｺｨｨｨｪ04 (Minocci et al., 2000; Yadav et al., 2011). 01ｨ 08ｨｮ0302ｨｪｨｨ02 ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ 05ｨｨ07ｨｨ ｨｨ ｨｪｨ ｨｺ ｨｪｨｨ02 ｨｨ ｨｨ ｨｪ0401, ｨｪ0200ｨ ｨｰｨｨ09ｨｪ ｨｨ0706ｨｴｨｨ01 ｨｪｨ ｨ ｨｨ0601ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ , ｨｨ ｨｰ ｨｰｨ ｨｺ0302 ｨｨ 09 08ｨ 0405ｨｨ ﾂｨｪ ｨｰ010205ｨ 01 ｨｬ060400ｨ, ﾂｨｰ ｨｨ090601ｨｨｨｰ ｨｺ 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ06ｨｦ 05ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ ｨｨ ｨ 02ｨｰ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ. 01ｨ ｨｨｨ 0605ｨｹ ｨｪｨ ﾂ02ｨｪｨｨ02 ｨｨｨｬ0202ｨｰ ｨ 0302ｨｪｨｨ02 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪ0609, ｨｺ06ｨｰ ｨｰ ｨｪ0609ｨｪ04ｨｬｨｨ 0902ｨｪ090608ｨ ｨｬｨｨ 02ｨｨ08ｨｺｨｮ05ｨｨ08ｨｮ06ｨｴｨｨ01 09 ｨｺ080609ｨｨ ｨｺ ｨｨ 05ｨｨ07ｨｨ ｨｨ 0609ｨｮｨｴ0209ｨｰ ｨｰ ｨｬ0601ｨｮ050702ｨｨ06 05ｨｪ ｨｰｨｨ ﾂ0209ｨｺ ｨｬ020609ｨｰｨ 04ｨ ｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｪｨ 01 ｨｨ ｨｰｨｺｨ ｨｪ ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ0902 ｨｨ 0108ｨｮ00ｨｨ01 06ｨｰ010205ｨ 01 ｨｬ060400ｨ ｨｰｨ ｨｺ0302 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｮ05ｨｹｨｰｨ ｨｰ06ｨｬ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 ｨｬ0601ｨｮ05ｨｨ08ｨｮ06ｨｴ ｨｨ07ｨｪｨｨ ｨｮ0507ｨｰ0608ｨｪ ｨｰｨｨ ｨｨ ｨｰ ｨ ｨｺｨｰ ｨｪｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ01 07ｨｮｨｰ02ｨｦ 05ｨｪ ｨｪｨｪ ｨｨ08ｨｪ0401 ｨｺｨｨ090506ｨｰ ｨｨ 05ｨｨ07ｨｨ ｨ 03ｨｪ02ｨｦ03ｨｨｨｬｨｨ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰｨ ｨｬｨｨ 05ｨｰｨｨ01 07ｨｮｨｰ02ｨｦ 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪｨ ｨｰ ｨｬ02ｨｪｨｰ04 ｪ ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｬｨ ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ ｨｨ 09ｨｨｨｪｨｰｨ 04ｨ 03ｨｨ08ｨｪ0401 ｨｺｨｨ090506ｨｰ, ｨ ｨｰｨ ｨｺ ｨｬ0203ｨｮｨｰ06 ﾂｨｪ ｨｮｨｺｨｰ04 ｨ ｨｨ0601ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｴ02ｨｪｨｨｨｦ ｪ ｨｬｨ 0506ｨｪｨｨ05-ｨｺ0605ｨｪ04ｨｨｨｬ 08 ｨｨ ｨｺ0605ｨｪ04ｨｨｨｬ 08, ｨｨｨｪ02ｨｪｨｪ04ｨｦ ｨｨｨｪｨｪ ﾂ02 ﾂｨｪ04ｨｬｨｨ 03ｨｨ08ｨｪ06ｨｺｨｨ090506ｨｰｨｪ04ｨｬｨｨ 08ｨ 01ｨｨｨｺｨ 05ｨ ｨｬｨｨ (Martinez de Morentin et al., 2010). 09ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ ｨｨ090601ｨｨｨｰ ｨｺ 08ｨ 0409ｨｨｨｰｨｨ06 09ｨｰ ｨ 05ｨｪ ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ ｨｰｨｨｨｺｨｮ05ｨｮｨｬｨ (050604), ｨｺ06ｨｰ ｨ 08ｨ ｨｺｨｰ0208ｨｪ04 ｨｪｨ 08ｨｮ0302ｨｪｨｨ ｨ ｨｺ06ｨｪ000608ｨｬｨ 02ｨｨ06ｨｪｨｪ ｨ ｨｪｨｨ07 ｨ 0205ｨｺ ｨｪ ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｬ 0802ｨｰｨｨｨｺｨｮ05ｨｮｨｬ02, 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｨ01 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ, ｨ ｨｰｨ ｨｺ0302 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｺ ｨｨｨｨ ｨ 0605ｨｹ ﾂｨｨ0905ｨ 0002ｨｪ ｨ 03ｨｪｨｮ ｨｹ 09 08ｨ 0409ｨｨｨｰｨｨｨｨ ｨｨ0008ｨ 02ｨｰ ｨｪｨｨ ｨ ｨｪｨｨ ｨｬ0602ｨｨ09ｨｰ02ｨｨｨｪｨ ｨ 04ｨｬ02 ｨｺ080609ｨｨ ｨｰ09ｨｨ02 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ ｨ ｨ 05ｨ ｨｪ09ｨ ｨｨ ｨｪｨｨ07 05ｨｪ0106ｨｰ0205ｨｨｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 09 ｨｮ ｨｨ0701 ｨｮｨｬ020802ｨｪｨｪ06ｨｦ 00ｨｨ ｨｨｨｺ02ｨｬｨｨｨｨ ｨｨ 01ｨｨ0905ｨｨ07ｨｨ0102ｨｬｨｨｨｨ, ｨｺ06ｨｰ ｨｪｨ ｨ ｨ 06ｨｰ ｨｮ ｨｨ ｨｨ0802ｨｪｨｨ07, ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺ ｨｨｨｪ010806ｨｬｨ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｹ ｨ 0409ｨｨｨｰｨｨｨｨ 09ｨｨ05ｨｹｨｪ ｨ 0302ｨｪｨｪ06ｨｦ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｮ ｨｪ ｨ ｨｬ02ｨｪｨ, 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ , ｨ 0405ｨ ｨｬ06ｨｪ09ｨｰ08ｨｨ080609ｨ ｨｪｨ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0401 ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｰｨｺｨ ｨｪ02ｨｦ ｨｨ 07ｨ ｨｪｨｺ0802ｨ ｨｰｨｨ ﾂ0209ｨｺｨｨ01 b-ｨｺ0502ｨｰ06ｨｺ (Ozcan et al., 2004; Huang et al., 2007; Wang et al., 2009) ｨ 05ｨｹｨｪ02ｨｦ0302ｨｬ ｨ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｨ04ｨ 04ｨｰ06 ﾂｨｪ ｨｰ0802ｨ 0502ｨｪｨｨ02 07ｨｨｨｴｨｨ 0708ｨｨ090601ｨｨｨｰ ｨｺ 08ｨ 0409ｨｨｨｰｨｨ ｨｪｨｨ ﾂ0209ｨｺ ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ0902 ｨｨ ｨ 02ｨｰ 09ｨｪｨｨ0302ｨｪｨｨ02 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｬ060400ｨ ｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｰｨｺｨ ｨｪ02ｨｦ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ ｨｨ ｨｰｨｨｨｪｨｮ, ﾂｨｰ06 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｰ0607ｨｪｨｨｨｦ (Zhang et al., 2008; Ozcan et al., 2009). 0206ｨｺｨ 04ｨ ｨｰ0205ｨｹ09ｨｰ0906ｨｬ ｨｹ04ｨｮ 0904ｨ ｨｨｨｬ ｨｨ ｨｬ020301ｨｮ ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ0902 ｨｨ 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｰ ｨｮ05ｨｹｨｰｨ ｨｰ04, ｨｮ ﾂ02ｨｪｨｪ ｨｬ06ｨｴｨｹ06 00ｨ 08ｨｬｨ ｨｺ ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｬ ｨｨ , ｨ ｨｪｨｪ06ｨｦ ｨｨｨｪｨｰ08ｨ ｨ 08ｨ 05ｨｹｨｪ04ｨｬ ｨｪｨｨ02ｨｬ ｨｬ0403ｨ ｨｬ ｨｰｨ 0709ｨｨ00ｨ 0800ｨｨｨｪｨ, ｨｨ00ｨｨ ﾂ0209ｨｺ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ Ca ｨ 0404 ｨｬ02ｨｬｨ 08ｨ ｨｪ04 05ｨｪ ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ ｨｰｨｨｨｺｨｮ05ｨｮｨｬｨ (Purkayastha et al., 2011). 02ｨ 0302 ｨｺ08ｨ ｨｰｨｺ ｨｬ02ｨｪｨｪ04ｨｦ, 09 ｨｰ02 ﾂ02ｨｪｨｨ ｨｮｨｰ, ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪｨ ｨ 05 ｨｪｨ 08ｨｮ0302ｨｪｨｨ02 ｨｰ ｨ ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｺ ｨｺ060402, 09ｨｨ09ｨｰ02ｨｬｨｪｨｮ06 ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609ｨｮ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ ｨｨ ｨｪｨｨ02 ｨ 08ｨｰ0208ｨｨｨ 05ｨｹｨｪ ｨ ｨｪｨｨ07. 06ｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ02 00ｨ ｨｺｨｰ0608ｨ NF-kB, ｨｺ06ｨｰ060804ｨｦ ﾂ02ｨｪ 09 ｨｬ060502ｨｺｨｮ050708ｨｪ0402 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ04 08ｨ 0409ｨｨｨｰｨｨ , ｨｨ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨ 03ｨｨ0906ｨｰｨｪ0401 ｨｰｨ ｨｮ0806ｨｮ ｨｺ09ｨｨ ｨｦ ｨｺｨｨ090506ｨｰ06ｨｦ ｪ ｨｬ06ｨｴｨｪ04ｨｬ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ060806ｨｬ ｪ ｨｪ0609ｨｰｨｹ ｨｰ0908ｨ ｨｴｨ 05ｨｨ ｨｪ0200ｨ ｨｰｨｨ09ｨｪ ｨｨ07ｨｪｨｨ02 ｨｰｨ 0709ｨｨ00ｨ 0800ｨｨｨｪｨ ｨｪｨ 00ｨｮｨｪｨｺ02ｨｨｨｨ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (Purkayastha et al., 2011). 09ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ ｨｨ ｨ 06ｨｰ ｨｪｨ -

3 1305ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ, ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ, ｨｨ ｨｰｨｨｨｪ06ｨｬ ｨｮ0302ｨｪｨｨ ｨ 0405ｨｨ ﾂｨｪ ｨｪｨｹ0701 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ, ｨｨ ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪｨ 01, ｨｬｨｪ0600ｨｨ02 ｨｨ04 ｨｺ06ｨｰ ｨｰ ｨ ｨｴｨｨｨｬｨｨ ｨｨ 0708ｨｨ ｨｰ ｨｺ 09ｨｨ09ｨｰ02ｨｬｨｪ06ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｺ ｨｰｨｨ01ｨ ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｬ02ｨｦ09ｨｰ09ｨ ｨｨ ｨｰｨｨｨｪｨｮ. 08 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ06 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ ｨｬ0600ｨｮｨｰ ｨｰｨ ｨｺ ｨｨ090601ｨｨｨｰｨｹ ｨｬ06ｨｪｨ 05ｨｹｨｪ0402 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07, ｨｪｨｨｨｺｨ 06ｨｴｨｨ ｨｮ00ｨｨ ｨｪｨｰ08ｨ 05ｨｹｨｪ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬｨ 01, ｨｮ06 06 ﾂ ｨｹ 09 ｨｬ0205ｨ ｨｪ06ｨｺ0608ｨｰｨｨｨｪ060906ｨｦ, ｨｰ06ｨｪｨｨｨｪ020800ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨ ｨ ｨｬｨｨｨｪ020800ｨｨ ﾂ0209ｨｺ06ｨｦ (Lustman, Clouse, 2005; Nogueiras et al., 2007; Zhou et al., 2007; 0107ｨ ｨｺ0609, 2012; 0107ｨ ｨｺ0609, ｨｺｨ ﾂ, 2012; Shpakov et al., 2012a, 2012b; Garber et al., 2013) ｨｹ 0708ｨ 0906ｨｬ0208ｨｪ ｨｨｨｰｨｹ ｨｪｨｰ08ｨ 05ｨｹｨｪ06ｨｬ 0002ｨｪ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｪ ｨｰ ｨ ｨｰ ｨｰ0209ｨｪ ｨ ｨｨｨｬ ｨｨ ｨｬ020301ｨｮ ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨｪ04ｨｬｨｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｬｨｨ ｨｬ060400ｨ, ｨｪｨ 08ｨｮ0302ｨｪｨｨ ｨｪ06ｨｦ ｨｨ05ｨｨ ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ01 ｨｨ04 ｨｺ06ｨｰ ｨｨｨｪ02ｨｨ07ｨｮ 0106ｨｬｨｨｨｪ ｨｨ ｨｰ ｨｺ 04ｨ 07ｨｮ09ｨｺｨｮ ｨｺ06ｨｬ0702ｨｪ09ｨ ｨｰ0608ｨｪ0401 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ ｨｮ00ｨｨ01 09ｨｨ09ｨｰ02ｨｬｨ 01, ﾂｨｰ ｨｮ09ｨｰ ｨｪｨｪ ｨｬ ｨ 02ｨｰ ｨｨｨｪｨｰ020008ｨ 02ｨｨ ｨｦ ｨｬ06ｨｪｨ 05ｨｹｨｪ06ｨｦ 0902ｨｰｨｨ ｨｬ060400ｨ ﾂ0209ｨｮ ｨｹ ｨｹ ｨｨ0008ｨ 06ｨｰ ｨｺ06ｨｬ0702ｨｪ09ｨ ｨｰ0608ｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨ 0205ｨｺ0609 ｨｨ05ｨｨ ｨｨ01 ｨｺｨ 09ｨｺｨ , ｨｺ06ｨｰ ｨｰ ｨ ｨｴｨｨｨｬｨｨ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰｨ ｨｬｨｨ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ, ｨｮ05ｨｨ08ｨｮ02ｨｬ ｨ 0405ｨｨ ﾂｨｪ04ｨｬｨｨ ｨｬ06ｨｪｨ ｨｬｨｨ ｨｨ ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨ ｨｬｨｨ (Shpakov et al., 2011; Shpakov, 2012). 08ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｰ0607ｨｪｨｨ02 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ 09 ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨ 01ｨｨ02ｨｨ06ｨｪｨｪ ｨｰ020702ｨｪｨｪ ｨｪｨ ﾂ02ｨｪｨｨ ｨｰｨｨ ｨｨｨｨ ｨｨ 07ｨ ｨｰ060002ｨｪ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｰ090601ｨｨｨｰ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｬｨｮ ｨｰ0607ｨｪｨｨ06 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ ｨｰ0907 ｨｨ09ｨｺ0506 ﾂ02ｨｪｨｨ02ｨｬ ｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609ｨ 07 09ｨｨ00ｨｪｨ 05ｨｹｨｪｨ 07 09ｨｨ09ｨｰ02ｨｬｨ ｨｬ060400ｨ, ｨｺ06ｨｰ0608ｨ ﾂ02ｨｪｨ ｨｮ050702ｨｨ06 00ｨｮｨｪ01ｨ ｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01 ｨｨ ﾂ ｨｪｨｰ08ｨ 05ｨｹｨｪ0402 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ04 ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｰ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ ｨｰ ｨｪｨ ｨｨ000208ｨｨｨｨ, 09 ｨｰ06ｨｬ ﾂｨｨ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨｰｨｺｨ ｨｪ02ｨｦ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ. 01ｨ 08ｨｮ0302ｨｪｨｨ07 09 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ02 ｨｬ060400ｨ, ｨ 06ｨｴｨｨ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ, ｨｰ0907 ｨｪ02 ｨｰ0605ｨｹｨｺ ｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺ06ｨｬ 09ｨｨｨｪ010806ｨｬ02, ｨｨｨ ｨ 02ｨｰ02 ｨｨ 05022, ｨｪ06 ｨｨ ｨｰ ｨｪ06ｨｦ ｨｨ04 ｨｺ0506 ﾂ ｨｨ ﾂｨｨｨｪ ｨ ｨｪｨｨ 0805ｨｹ020002ｨｦｨｬ0208ｨ, 08ｨ 0909ｨｬｨ ｨｰ08ｨｨ09ｨ 02ｨｬ06ｨｦ ｨｺｨ ｨｺ ｨｰｨｨ07ｨ, ｨｨ 0108ｨｮ00ｨｨ01 ｨｪ02ｨｦ ｨｪ0208ｨ ｨｰｨｨ09ｨｪ ｨ ｨ ｨ ｨｪｨｨｨｦ (de la Monte, 2010; de la Monte, Tong, 2014). 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 09 ｨｰｨｺｨ ｨｪ0701 ｨｬ060400ｨ ｨｨｨｬ0206ｨｰ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨ ｨｺｨｰｨｨ09ｨｪ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｰ (0604) (Boura-Halfon, Zick, 2009). 06ｨｪ09ｨｮ05ｨｨｨｪ, 09ｨｨｨｪｨｰ0204ｨｨ08ｨｮ02ｨｬ04ｨｦ ｨｪ0609ｨｪ06ｨｬ b-ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ 0609ｨｰ080609ｨｺ ｨ ｨｪ ｨ ｨｪ09ｨ ｨｮ0106 ﾂｨｪ06ｨｦ , ｨｺ ｨｪｨｨｨｺｨ 02ｨｰ 09 ｨｬ ﾂ ｨｬｨ ｨｰ0605ｨｪ020200ｨ 05ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨ ｨ 08ｨｹ0208, ｨ 02ｨｰ0907 ｨｰｨ ｨｬ , 09ｨｰｨｨｨｬｨｮ05ｨｨ08ｨｮ02ｨｰ ｨｨ01 ｨｰｨｨ080604ｨｨｨｪｨｺｨｨｨｪｨ 04ｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ ｨ 02ｨｰ ｨｨ05ｨｨ080609ｨ ｨｪｨｨ02 ｨ 0205ｨｺ0609 ｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｰ0608ｨｪ ｨｮｨ 09ｨｰ08ｨ ｨｰ ｨｨ ｨｰｨｨ (IRS1 ｨｨ IRS2) (08ｨｨ09. 1). 06ｨｰ ｨｨ090601ｨｨｨｰ ｨｺ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｪｨｨ ｨ ｨｴｨｨ ｨｺｨｰ0608ｨｪ0401 ｨ 0205ｨｺ0609, ｨｺ06ｨｰ ﾂ02ｨｪ04 09 ｨｺ06ｨｪｨｰ080605ｨｹ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ 09ｨｨ09ｨｨｨｬ ｨｰ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ ｨ ｨｺｨｰ , 06ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ ｨ ｨｰ, 01ｨｨ ｨｪ02ｨｨ080609ｨ ｨｪｨｨ02, ｨ ｨｰ0604 ｨｨ 0108ｨｮ00ｨｨ02 00ｨｮｨｪ01ｨ ｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｪ04ｨｦ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ 0102ｨｦ09ｨｰ09ｨｨ07 ｨｮ09ｨｰｨ ｨｪ ｨｪ ｨｨ , ｨｺ06ｨｰ060804ｨｦ, ｨｰｨ ｨｺ 0302 ｨｺｨ ｨｺ ｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ, 06ｨｰｨｪ0609ｨｨｨｰ0907 ｨｺ ｨｰｨｨ01ｨ ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｬ02ｨｦ09ｨｰ09ｨ ｨｨｨｪｨｰ0204ｨｨ08ｨｮ02ｨｰ ﾂ02ｨｪｨｨ ｨｨ ｨｬ ｨｨ 0609ｨｮｨｴ0209ｨｰ ｨｰ ｨｨ ｨｮ0507ｨｰ0608ｨｪ ｨｺｨｰ04 ｨｪｨ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0402 ｨｨ 0005ｨｨｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ ﾂ ｨｪｨ ｨｪｨｪ0402 ｨｰｨｨ080604ｨｨｨｪｨｺｨｨｨｪｨ 04ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｰ ( ) ｨｨ ｨｺｨ 05ｨｨ040609ｨ ｨｪ ｨｬｨｪ0600ｨｨ01 06ｨｰ010205ｨ 01 ｨｬ060400ｨ 09 ｨｪｨ ｨｨｨ 0605ｨｹ0302ｨｦ ｨｨ ｨｰｨｪ0609ｨｰｨｹ ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｮｨｺ0609ｨｨ02ｨ 01, 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ0902, 00ｨｨ070706ｨｺｨ ｨｬ0702 ｨｨ ｨｺ ｨｪ ｨｬ060400ｨ, ﾂｨｰ06 ｨｮｨｺｨ ｨ 02ｨｰ ｨｪｨ ｨｺ0506 ﾂ0209ｨｮ ｨｹ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ ｨｨ ｨｺ06ｨｪｨｰ ｨｪ ｨｰｨｨ ﾂ0209ｨｺ ｨｬ020609ｨｰｨ 04ｨ, ｨｮ050702ｨｨｨｨ ｨｪ02ｨｦ ｨｪ0204ｨ ｨｨ 09ｨｨｨｪｨ 07ｨｰ060002ｨｪ0204ｨ. 05ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ, ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ ｨｨ , ｨｨｨｬ0206ｨｰ ｨｬｨｪ ｨ ｨｴｨｨ ｨｪｨｹ0209 ｨｨ ｨｰ0209ｨｪ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ06ｨｰ ｨｮ00ｨｨｨｬｨｨ ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨｪ04ｨｬｨｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｬｨｨ ｨｰ09ｨｨ02 05ｨｰ ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｨ ｨ ｨｪｨｪ06 ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ 09 ｨｺ06ｨｪｨｰ ｨｨｨｴ ｨｪｨｨ07, 07ｨ ｨｬ07ｨｰｨｨ, 06ｨ ｨｮ ﾂ02ｨｪｨｨ07, ｨｨ09ｨｪ ｨｰ0607ｨｪｨｨｨｦ ｨｨ ｨｰ0208ｨｬ ｨｮ050702ｨｨｨｨ, ｨｮ050702ｨｨ06 ｨｺ06ｨｰ ﾂ02ｨｪ06 ｨｬｨｪ ｨｰ ｨｮ00ｨｨ ｨｬ06ｨｪ0609 ｨｨ ｨｰ ｨ ｨｺｨｰ ｨｺｨ ｨ ｨｨ07ｨｪｨｨ02 ｨｪｨ 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ02 ｨｪ02ｨｦ0806ｨｪ04, ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｨ ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ06ｨｰ ｨｪ0609ｨｪ ｨｪｨｹ07 05ｨｪ0106ｨｺ08ｨｨｨｪｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 ｨｨ ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ﾂ ｨｪ0202 ｨ ｨｨ0601ｨｨｨｬｨｨ- ﾂ0209ｨｺｨｨ02 ｨｨ 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ (D ｯErcole et al., 2002; Bondy, Cheng, 2004; Gerozissis, 2008). 0201ｨｪｨｨｨｬ ｨｨ04 09ｨ 03ｨｪ02ｨｦ03ｨｨ01 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨｺｨ 09ｨｺｨ , ｨｮ05ｨｨ08ｨｮ02ｨｬ0401 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ ｨｨ , ｨｰ ｨｨｨｪ0604ｨｨｨｰｨｨ01ｨｪ04ｨｦ 07ｨｮｨｰｨｹ, 09ｨｺ0506 ﾂｨ 06ｨｴｨｨｨｦ ｨ 07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｪｨｪｨｮ06 09 IRS-ｨ 0205ｨｺｨ ｨｬｨｨ p110/p ｨｰ ｨｨｨｬ0208ｨｪｨｮ ｨ ｨｰｨｨ01ｨｨ05ｨｨｨｪ0604ｨｨｨｰ ｨｺｨｨｨｪｨ 04ｨｮ (PI3K), ｨｺｨ ｨｰｨ 05ｨｨ04ｨｨ08ｨｮ06ｨｴｨｮ06 06ｨ 08ｨ ｨ ｨｪｨｨ02 09ｨｰ0608ｨｨ ﾂｨｪ ｨｪｨｨｨｺ ｨ ｨｰｨｨ01ｨｨ05ｨｨｨｪ0604ｨｨｨｰ0605-3,4-01ｨｨ ｨ ｨｰｨ ｨｨ ｨ ｨｰｨｨ01ｨｨ05ｨｨｨｪ0604ｨｨｨｰ0605-3,4,5-ｨｰ08ｨｨ ｨ ｨｰｨ, ｨｨ ｨｨｨｪ/ｨｰ080206ｨｪｨｨｨｪ ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 0404 ｪ ｨｨｨｪ0604ｨｨｨｰｨｨ0104ｨ 09ｨｨ09ｨｨｨｬｨｮ06 ｨｺｨｨｨｪｨ 04ｨｮ-1 ｨｨ ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨｮ B (AKT-ｨｺｨｨｨｪｨ 04ｨｮ) ｨ 02ｨｬｨ 07 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 AKTｨｺｨｨｨｪｨ ｨｨ090601ｨｨｨｰ ｨｺ ｨｰ08ｨ ｨｪ090506ｨｺｨ 02ｨｨｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ ｨｰ08ｨ ｨｪ ｨｰ0208ｨ GLUT ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｮ06 ｨｬ02ｨｬｨ 08ｨ ｨｪｨｮ ｨｨ ｨ 02ｨｰ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06 04ｨ 0109ｨ ｨｰｨ ｨｺ ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ. AKT-ｨｺｨｨｨｪｨ 04ｨ ｨｰｨ ｨｺ0302 ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｺｨｨｨｪｨ ｨｨｨｺ060002ｨｪ09ｨｨｨｪｨｰ02ｨｰｨ 0404, ｨｺ06ｨｰ0608ｨ ｨｮ05ｨｨ08ｨｮ02ｨｰ 09ｨｨｨｪｨｰ ｨ 0601ｨｪ ｨｨ08ｨｪ0401 ｨｺｨｨ090506ｨｰ ｨｨ 0005ｨｨｨｺ060002ｨｪｨ, ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ02ｨｰ ｨ ｨｰ0604, 09ｨｰｨｨｨｬｨｮ05ｨｨ08ｨｮ02ｨｰ ｨｨ09ｨ 02ｨｬ0609ｨｰｨｹ ｨｺ0502ｨｰ06ｨｺ ﾂ ｨｰ ｨｨ05ｨｨ080609ｨ ｨｪｨｨ07 ｨ 0205ｨｺ0609 BAD (BCL2 Antagonist of Cell Death) ｨｨ FKHRL1 (ForKHead-ReLated Family of Mammalian Transcription Factor-1). 01ｨ ｨｮ 09 05ｨｰｨｨｨｬ AKT-ｨｺｨｨｨｪｨ 04ｨ ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｰ ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨｮ mtor (mammalian Target Of Rapamycin), ﾂｨｰ ｨｨ090601ｨｨｨｰ ｨｺ ｨｨ05ｨｨ080609ｨ ｨｪｨｨ06 08ｨｨｨ ｨｬｨ 05ｨｹｨｪ06ｨｦ S6-ｨｺｨｨｨｪｨ 0404 ｨｨ ｨｨｨｰ ｨｪ ｨｮ050702ｨｨｨｨ ｨｰ08ｨ ｨｪ ｨｨｨｨ ｨｬｨｪ ｨｰ09ｨ ｨｺ05ｨ ｨｬ (08ｨｨ09. 1). 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｬｨｨ0302ｨｪｨｹ06 AKT-ｨｺｨｨｨｪｨ ｨｰ0907 ｨ ｨｺ FBP-1 (forkhead-box protein-1), ｨｪ0200ｨ ｨｰｨｨ09ｨｪ04ｨｦ ｨｮ0507ｨｰ0608 ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｨ00ｨｪｨ 05ｨｨｨｪ00ｨ, ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｺ06ｨｰ ｨ 02ｨｰ ｨｮ09ｨｨ0502ｨｪｨｨ ｨｰ0802ｨ 0502ｨｪｨｨ07 07ｨｨｨｴｨｨ ｨｨ 0603ｨｨ0802ｨｪｨｨ02 (Kitamura et al., 2006) ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ ｨｰｨｨ07ｨ, ｨｺ06ｨｰ ｨ 08ｨ ｨｺｨｰ0208ｨｪ ｨｨ02ｨｨｨｰ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ ｨｨ 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｬ , 09 ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨｮ080609ｨｪ07 05ｨｰｨｨ ｨｬ06ｨｪ0609 ｨｪ02 ｨ ｨｪ06 (Clauson et al., 1998; Varewijck et al., 2012). 05ｨｪｨｨ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨ ｨｨ ｨｰｨｮ07ｨｪ (090906ｨ 0601ｨｪ060006) ｨｪｨ ｨ ｨ 05ｨｨ 0708ｨｨ 0105ｨｨｨｰ0205ｨｹｨｪ06 ｨｰ02ｨｺｨｮｨｴ02ｨｬ ｨｨ 09 ｨｮ ｨｨ0701 ｨｪ02ｨ 0102ｨｺ09ｨ ｨｰｨｪ ｨｨｨｺ02ｨｬｨｨ ﾂ0209ｨｺ ｨｺ06ｨｪｨｰ , 0708ｨｨ ﾂ02ｨｬ 0708ｨｨ ﾂｨｨｨｪ06ｨｦ 05ｨｰ ｨｹ ｨｪ02 09ｨｪｨｨ0302ｨｪｨｨ02 06ｨ ｨｴ , ｨ 0109ｨｮｨｺ08ｨ ｨｰｨｪ ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨ 06ｨｴ ｨ 0205ｨｺｨ ｨｰｨｨ07ｨ ( ) (Clauson et al., 1998; Akturk et al., 2007). 06ｨｪｨｰ ｨｪ ｨｨｨｰｨｹ 01ｨｨｨｪｨ ｨｬｨｨｨｺｨｮ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｪｨ 08ｨ 0405ｨｨ ﾂｨｪ ｨｰｨ 01ｨｨ ｨ 0409ｨｨｨｰｨｨ07 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｨ ｨ ｨｪｨｪ ｨｰｨｨｨｬ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ01 08ｨ 0909ｨｰ0806ｨｦ09ｨｰ09. 06ｨ ｨｺ, ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｨ0802ｨｪｨｨ02ｨｬ, ｨｮ ｨｺ06ｨｰ ｨｰｨｬ02- ﾂｨ 05ｨｨ 05ｨｨ03ｨｹ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ ｨｪｨｨ0302ｨｪｨｨ02 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｰｨｺｨ ｨｪ02ｨｦ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ, ｨｮ ｨｪｨｹ 06ｨ ｨｴ ｨ ｨｬ02ｨｰｨｪ06 ｨｪ02 ｨｬ02ｨｪ , 09 ｨｰ ｨｬ07 ｨｺｨ ｨｺ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ ｨ 0601ｨｪ

4 ｨ ｨｺ ｨｨ , ｨｨｨｪ0604ｨｨｨｰｨｨ01ｨｪ ｨｮｨｰｨｨ, ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ. IRS1/2 ｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｰ0608ｨｪ ｨｮｨ 09ｨｰ08ｨ ｨｰ ｨｨ ｨｰｨｨ070609, PI3K ｪ ｨ ｨｰｨｨ01ｨｨ05ｨｨｨｪ0604ｨｨｨｰ ｨｺｨｨｨｪｨ 04ｨ, PI-3,4,5-P 3 ｪ ｨ ｨｰｨｨ01ｨｨ05ｨｨｨｪ0604ｨｨｨｰ0605-3,4,5-ｨｰ08ｨｨ ｨ ｨｰ, GLUT4 ｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ04ｨｦ ｨｺ0604ｨｪ04ｨｦ ｨｰ08ｨ ｨｪ ｨｰ ｨｰｨｨ07ｨ, PDK ｪ ｨｨｨｪ0604ｨｨｨｰ060504ｨ 09ｨｨ09ｨｨｨｬｨ ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ, AKT ｪ ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ B (AKT-ｨｺｨｨｨｪｨ 04ｨ ), PKC ｪ ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ C, GSK3 ｪ ｨｺｨｨｨｪｨ 04ｨ ｨｨｨｺ060002ｨｪ09ｨｨｨｪｨｰ02ｨｰｨ 0404, FKHRL1 ｪ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ04ｨｦ 00ｨ ｨｺｨｰ ｨｬ02ｨｦ09ｨｰ09ｨ Forkhead (For- KHead-ReLated Family of Mammalian Transcription Factor-1), BAD ｪ ｨ ｨｪｨｰｨ 0006ｨｪｨｨ09ｨｰ BCL2 09 ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 00ｨｨｨ 0205ｨｨ (BCL2 Antagonist of Cell Death), mtor ｪ ｨｨｨｪ/ｨｰ080206ｨｪｨｨｨｪ0609ｨ ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ (mammalian Target Of Rapamycin), p70s6k ｪ p70-08ｨｨｨ ｨｬｨ 05ｨｹｨｪｨ 07 S6-ｨｺｨｨｨｪｨ 04ｨ. ｨｪ02ｨｬｨｪ ｨ 05ｨ 09ｨｹ ｨｰ09ｨｨ02 09ｨｪｨｨ0302ｨｪｨｨ07 ｨｮ080609ｨｪ ｨ 05ｨｹｨｪ02ｨｦ0302ｨｬ 0708ｨｨ ｨｮ09ｨｨ0502ｨｪｨｨｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｨ 08ｨ 0409ｨｨｨｰｨｨｨｨ ｨｨｨ ｨ 02ｨｰｨ, ｨ ｨｰ09ｨｨｨｨ ｨｨ 0709ｨｪ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ ｨ 05ｨ 09ｨｹ, ﾂｨｰ ｨｨ090601ｨｨ0506 ｨｺ 09ｨｪｨｨ0302ｨｪｨｨ06 ｨｮ080609ｨｪ ｨ 0601ｨｪ (Frystyk et al., 1999). 0308ｨｨ ﾂｨｨｨｪ06ｨｦ 09ｨｪｨｨ0302ｨｪｨｨ07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨ 0601ｨｪ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｰｨ ｨｺ ｨｪｨｨ02 ｨｮ080609ｨｪ , ｨｪｨ ﾂｨｰ06 ｨｮｨｺｨ ｨ 02ｨｰ 06ｨｰ ﾂ02ｨｰ05ｨｨ ｨ 0302ｨｪｨｪ ｨｪｨｨ0302ｨｪｨｨ ｨｰｨｪ060302ｨｪｨｨ / ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ (Cortizo et al., 1998) ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ ｨｪｨｨ02 ｨｮ080609ｨｪ07 08ｨ 0405ｨｨ ﾂｨｪ ｨｬ ｨ ｨｪ06 09 ｨｮ09ｨｨ0502ｨｪｨｨ02ｨｬ ｨｪ0205ｨｪ04ｨｨｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ ｨｨｨｺ0604ｨｨ05ｨｨ080609ｨ ｨｪｨｨ07 05ｨｰｨｨ01 ｨ 0205ｨｺ ｨｮ ｨｨ0701 ｨｮｨｬ020802ｨｪｨｪ06ｨｦ 00ｨｨ ｨｨｨｺ02ｨｬｨｨｨｨ, ｨｺ06ｨｰ0608ｨ 07 01ｨ 08ｨ ｨｺｨｰ0208ｨｪｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｪｨｨ02 ｨｮ080609ｨｪ ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨｨｰ0205ｨｹｨｪ06 ｨｺ ｨｨ08ｨｮ02ｨｰ 09 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｰｨｺｨ ｨｪ0701 ｨｨ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｨ ｨｹ040609ｨ ｨｪ06 09 ｨｺｨ ﾂ0209ｨｰ0902 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ ｨｬｨ 08ｨｺ0208ｨ ｨｨ0102ｨｪｨｰｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｪｨ 08ｨｮ0302ｨｪｨｪ06ｨｦ ｨｰ ｨ ｨｪｨｰｨｪ0609ｨｰｨｹ06 ｨｺ ｨｺ ｨｨ 09ｨｪｨｨ0302ｨｪｨｪ06ｨｦ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ06, ｨｰ09ｨｮ06ｨｴｨｨ01 08ｨ 0409ｨｨｨｰｨｨ ｨｪ (Lopez-Bermejo et al., 2006; Ruan, Lai, 2010). 06ｨｬ0206ｨｰ ｨｪ0609ｨ ｨｪｨｨ ｨ 00ｨ ｨｰｨｹ, ﾂｨｰ ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 06ｨ ｨｴ ｨｮ05ｨ ｨｰ ｨｪ06ｨｦ ｨｨ ｨｨ ﾂｨｨｨｪ ｨｪ ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｨ ｨｪ02ｨｦ ｨｪ0208ｨ ｨｰｨｨ09ｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ, ｨｪｨｨｨｺｨ 06ｨｴｨｨ01 09 ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022, ｨｰ02ｨｬ ｨ ﾂｨｰ06 09ｨｪｨｨ0302ｨｪｨｨ ｨｰｨｪ060302ｨｪｨｨ / ｨ 08ｨ ｨｺｨｰ0208ｨｪ ｨ ｨｪｨｨ 0805ｨｹ020002ｨｦｨｬ0208ｨ ｨｨ ｨｮ01ｨｨ09ｨｰ06ｨｦ 0102ｨｬ02ｨｪ02ｨｨｨｨ, ｨｺ06ｨｰ ﾂｨ 09ｨｰ ｨｰ0802 ﾂｨ 06ｨｰ0907 ｨｮ 01ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 07ｨ 02ｨｨ02ｨｪｨｰ0609 (Zhu et al., 2005). 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨ 0601ｨｪ ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ 08ｨ ｨｪｨｪ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 0601ｨｪｨｨｨｬ ｨｨ04 00ｨ ｨｺｨｰ , ｨ 06ｨｴｨｨ ｨ ｨ 0502ｨｪｨｨ02 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨ 09ｨｨ09ｨｨｨｬ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｮｨｰ02ｨｦ 09 ｨｬ ｨｪｨ ｨｺ06 06ｨ ｨｴ020708ｨｨｨｪ07ｨｰ06ｨｦ ｨｰ0907 ｨｰ06 ﾂｨｺｨ ｨｪｨｨ07 06 ｨｰ06ｨｬ, ﾂｨｰ ｨｪ0609ｨｪ04ｨｬｨｨ 0708ｨｨ ﾂｨｨｨｪｨ ｨｬｨｨ 09ｨｪｨｨ0302ｨｪｨｨ07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ ｨｨ 05ｨｰｨｨ01 07ｨ ｨｰ ｨｨ0701, ｨｺｨ ｨｺ ｨｨ ｨｮ ﾂｨ 02 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04, ｨｰ0907 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ ｨｰ0608ｨｪ0401 ｨｨ ｨｺｨｰ0608ｨｪ0401 ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ ｨｬ040302ｨｦ, 05ｨｨ0302ｨｪｨｪ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01 (neuron-specific IR knockout, NIRKO), ｨｪｨ ｨ ｨ 02ｨｰ ｨｨ ｨ 00ｨｨ07 ｨｨ 08ｨ 0409ｨｨ09ｨ 02ｨｰ ｨ 09ｨｨ09ｨｨｨｬ ｨｰ 01ｨｨ02ｨｰ ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺ ｨｰ0607ｨｪｨｨ02, ｨｺ06ｨｰ ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ02ｨｰ ｨｪｨｨ02ｨｬ ｨｬｨ ｨｰ0205ｨ, 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｮｨｬ020802ｨｪｨｪ06ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ, 00ｨｨ ｨｨｨｺ02ｨｬｨｨ02ｨｦ, ｨｪｨｨ02ｨｬ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ, ｨｰｨｨｨｪｨ ｨｨ ｨｰ08ｨｨ0005ｨｨ020208ｨｨ (Bruning et al., 2000; Koch et al., 2008). 01ｨｨ ｨ 00ｨｨ06 ｨｨ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ06 ｨｬｨ ｨｰ0205ｨ ｨ 02ｨｰ ｨｨ ｨ ｨｪｨｨ02 05ｨｺ ｨｨｨｨ 0002ｨｪｨ, ｨｺ0601ｨｨ08ｨｮ06ｨｴ , 09 06ｨｰ010205ｨｹｨｪ ｨ 01 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09ｨ ｨｬ040302ｨｦ (Obici et al., 2002a). 06ｨｰｨｨ 01ｨ ｨｪｨｪ0402 ｨｮｨｺｨ ｨ 06ｨｰ ｨｪｨ ｨｺ0506 ﾂ0209ｨｮ ｨｹ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ ｨｬ060400ｨ ｨｮ050702ｨｨｨｨ 00ｨｮｨｪｨｺ02ｨｨｨｦ 03ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨｨ ｨｮｨｺ02ｨｨｨｨ ｨｺ ﾂ02ｨｪｨｹ ｨ ｨｬ ｨｬ040302ｨｦ, ｨｪ06ｨｺｨ ｨｮｨｰｨｪ ｨｪｨｮ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01, ｨｪｨ 08ｨｮ03ｨ 02ｨｰ ｨｬｨ ｨｰ060002ｨｪ0204 ｨｨ 09ｨｪｨｨ03ｨ 02ｨｰ ｨｰｨｨ05ｨｹｨｪ0609ｨｰｨｹ, 09 ｨｰ ｨｬ07 ｨｺｨ ｨｺ ｨｮ 09ｨ ｨｬ06ｨｺ ｨｪ06ｨｦ ｨｬｨｮｨｰｨ 02ｨｨ02ｨｦ ｨｪｨ 08ｨｮ03ｨ 02ｨｰ ｨ ｨｪｨｨ ｨｨｨｺｨｮ050708ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 07ｨｨ ﾂｨｪｨｨｨｺ ｨｪｨｨ0302ｨｪｨｨ ｨｮｨｺｨｰｨｨ09ｨｪ06ｨｦ 00ｨｮｨｪｨｺ02ｨｨｨｨ ｨｰ ｨｰ09ｨｨ02ｨｬ ｨ ｨ 0502ｨｪｨｨ ｨｺ080202ｨｨｨｨ 08ｨｨ05ｨｨ04ｨｨｨｪ00-00ｨ ｨｺｨｰ0608ｨ 0506ｨｰ02ｨｨｨｪｨｨ04ｨｨ08ｨｮ06ｨｴ ｨｬ06ｨｪｨ 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨｪ02ｨｦ0806ｨｪｨ ｨｬｨｨ 09 ｨｮ ｨｨ0701 ｨｪｨ 08ｨｮ0302ｨｪｨｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｨ00ｨｪｨ 05ｨｨｨｪ00ｨ ｨｰｨ ｨｪ ｨｪｨｨ02 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0604 ｨｮ

5 1305ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ, ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ, ｨｨ ｨｰｨｨｨｪ06ｨｬ 793 ｨｪ06ｨｺｨ ｨｮｨｰｨｪ0401 ｨｬ040302ｨｦ 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｪ0608ｨｬｨ 05ｨｨ04ｨ 02ｨｨｨｨ 05ｨｪ ｨｰｨｨ ﾂ0209ｨｺ ｨｬ020609ｨｰｨ 04ｨ, ｨｰ0908ｨ ｨｴｨ 02ｨｰ 08ｨ 0409ｨｨｨｰｨｨ ｨｨｨ ｨ 02ｨｰｨｨ- ﾂ0209ｨｺ ｨｰ0607ｨｪｨｨ07 ｨｨ ﾂｨ 09ｨｰｨｨ ﾂｨｪ ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ 02ｨｰ ｨｨ ｨｮｨｺｨｰｨｨ09ｨｪ ｨｮｨｪｨｺ02ｨｨｨｨ (Okamoto et al., 2004). 06ｨｺ ｨｨ ｨｪｨ ｨｬ ｨｬ040302ｨｦ, ｨｪ06ｨｺｨ ｨｮｨｰｨｪ ｨ 04ｨｮ ｨｮｨｬ 0002ｨｪｨ ｨｬ ｪ 0604 ｨｨ ｨｺ0604ｨｪ ｨｰ08ｨ ｨｪ ｨｰ0208ｨ GLUT4, ｨ 02ｨｰ ｨｨ ｨｨ09ｨ 02ｨｬ0609ｨｰｨｹ ｨｨ ｨｮ05ｨｮ ﾂ03ｨ 02ｨｰ 0706ｨｺｨ 04ｨ ｨｰ0205ｨｨ 05ｨｪ ｨｰｨｨ ﾂ0209ｨｺ ｨ ｨｬ02ｨｪｨ, ｨｪ ｨｪ06ｨｦ ｨｬ ｨｪ02 ｨｮ09ｨｰ08ｨ ｨｪ0702ｨｰ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ0402 ﾂ0208ｨｰ ｨｨｨ ｨ 02ｨｰｨ, ﾂｨｰ ｨ ｨｪ ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ02ｨｬ ｨｮ 03ｨｨ0906ｨｰｨｪ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨ ｨｺｨｰｨｨ09ｨｪ GLUT4, 06ｨ ﾂｨｨ09ｨ 06ｨｴ ｨ 0109ｨ ｨｰ ｨｺ ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ (Lin, Accili, 2011). 00 ｨｬ NIRKO-ｨｬ040302ｨｦ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｮ02ｨｰ 09ｨｰｨｨｨｬｨｮ050702ｨｨ07 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ PI3K, 09 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｪ ｨｨ05ｨｨ080609ｨ ｨｪｨｨ02 AKT-ｨｺｨｨｨｪｨ 0404 ｨｨ ｨｺｨｨｨｪｨ b 0005ｨｨｨｺ060002ｨｪ09ｨｨｨｪｨｰ02ｨｰｨ 0404, ｨｮ05ｨｹｨｰｨ ｨｰ06ｨｬ ﾂ ｨｰ0907 ｨｮ09ｨｨ0502ｨｪｨｨ ｨｨ05ｨｨ080609ｨ ｨｪｨｨ07 ｨ ｨｨｨｨ080609ｨ ｨｪｨｪ ｨｬｨｨｨｺ0806ｨｰ08ｨｮｨ 06 ﾂｨｺｨ ｨｬｨｨ Tau-ｨ 0205ｨｺｨ ｨ ｨｦｨｰｨ ｨｬ, ｨｺ06ｨｰ ｨ ｨｪ04 09 ｨｪ02ｨｦ ｨｪ0208ｨ ｨｰｨｨ09ｨｪ04ｨｬｨｨ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07ｨｬｨｨ 09 ｨｬ (Koch et al., 2008) ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ06 09ｨ ｨｦｨｰ ｨｨ00ｨｨ ﾂｨｪ ｨｨ05ｨｨ080609ｨ ｨｪｨｨ02 Tau-ｨ 0205ｨｺｨ ｨｰ ｨｪｨｨｨｬ ｨｨ04 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609, ｨｺ06ｨｰ060804ｨｦ ｨ 02ｨｰ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ ｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｨ00ｨｪｨ 05ｨｨｨｪ00ｨ 09 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｪ02ｨｦ ｨｪ0208ｨ ｨｰｨｨ09ｨｪ ｨ ｨ ｨ ｨｪｨｨｨｦ (Schubert et al., 2004). 00 ｨｬ ｨｮｨｪ ｨｪ020002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨｬ ｨｬｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022, ｨｺ06ｨｰ ｨ 05ｨｨ ｨｺ0603ｨｨ ｨｦ 01ｨｨ02ｨｰ06ｨｦ ｨｨ 0706ｨｰ0802ｨ 0502ｨｪｨｨ02ｨｬ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0401 ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｺ ｨｨ 0008ｨｮｨｺｨｰ060404, ｨｰ ｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ 05ｨｺ ｨｨｨｨ ｨｨ ｨ 06ｨｴｨｨ01 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺ ｨ 09ｨｪ02ｨｪｨｨｨｨ ｨｬｨｨ 03ｨｨ0906ｨｰｨｪ04ｨｬｨｨ ｨｪ06 ｨｪ02 ｨ (Li et al., 2007) ｨｺ0605ｨｹｨｺｨｮ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060904ｨｦ 09ｨｨ00ｨｪｨ 05ｨｨｨｪ00 09 ｨｬ ｨｮ ｨｪｨｨ01 ｨ ｨ ｨ 0502ｨｪ, ｨｪｨ 08ｨｮ0302ｨｪｨｨ07, ｨｺｨ ｨｺ ｨｬ0603ｨｪ ｨ 00ｨ ｨｰｨｹ, 0506ｨｺｨ 05ｨｨ040609ｨ ｨｪ ｨｮ00ｨｨ01 ｨ 0506ｨｺｨ 01 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ ｨｨ 05ｨｰ06ｨｬ 06ｨｰｨｬ02 ﾂｨ 05ｨｨ 04ｨ ｨｬ02ｨｰｨｪ ｨｪｨｨ0302ｨｪｨｨ02 05ｨｺ ｨｨｨｨ ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ , ﾂｨｰ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ 06ｨ ｨ ｨ 0502ｨｪｨｨｨｨ ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 09 ｨｬ ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｺ (Li et al., 2007) ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ06 ｨｪ020002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ02 ｨｬ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨ ｨ 05ｨｨ04ｨｺｨｨ ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨｨｬ 04ｨ ｨ ｨ ｨｪｨｨ07ｨｬ ﾂ ｨｺｨ. 06ｨｪ000608ｨｬｨ 02ｨｨ ｨｰｨｪ060302ｨｪｨｨｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｰ0607ｨｪｨｨ07 IRS-ｨ 0205ｨｺ ｨｬ ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨ ｨｪｨｨ ﾂ02ｨｪｨｪｨ. IRS-ｨ 0205ｨｺｨｨ ｨｰ0907 ｨｺ0506 ﾂ020904ｨｬ ｨｪ06ｨｬ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ08ｨ ｨｪ0901ｨｮｨｺ02ｨｨｨｨ, ｨｺ0605ｨｹｨｺｨｮ 06ｨｪｨｨ ｨｪ02 ｨｰ0605ｨｹｨｺ ｨｮｨｴ0209ｨｰ ｨｰ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｪｨｨ02 ｨｬ020301ｨｮ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰｨ ｨｬｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ, ｨｪ06 ｨｨ ｨｮ06ｨｰ cross-talk ｨｬ020301ｨｮ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ04ｨｬｨｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｬｨｨ ｨｬ060400ｨ, ｨｮ05ｨｨ08ｨｮ02ｨｬ04ｨｬｨｨ 08ｨ 0405ｨｨ ﾂｨｪ04ｨｬｨｨ ｨｬ06ｨｪｨ ｨｬｨｨ ｨｨ ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨ ｨｬｨｨ. 05ｨｪｨｨ0302ｨｪｨｨ02 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ IRS-ｨ 0205ｨｺ0609 ｨｨ05ｨｨ ｨｨ ｨｺ0506 ﾂ02ｨｪｨｨ ｨｨ090601ｨｨｨｰ ｨｺ 08ｨ 0409ｨｨｨｰｨｨ06 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ, 00ｨｨ ｨ 00ｨｨｨｨ, ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬ ｨｮ ｨｪ ｨｨ 05ｨｨ07ｨｨ01ｨｪ ｨ ｨｬ02ｨｪｨ ｨｨ 09 ｨｺ06ｨｪ02 ﾂｨｪ06ｨｬ ｨｨｨｰ ｪ ｨｺ ｨｨｨ ｨ 02ｨｰｨｮ ｨｨ (Lee, White, 2004) ｨｨ ｨｪｨ irs2 09 ｨｪ02ｨｺ06ｨｰ ｨｰ010205ｨ 01 ｨｬ060400ｨ ｨｬ040302ｨｦ, 09 ｨｰ06ｨｬ ﾂｨｨ ｨ 01 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09ｨ, ｨ 02ｨｰ ｨｪｨｨ02 ｨ ｨｰｨｨｨｰｨ, ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 03ｨｨ ｨｦ ｨｨ ｨｬ ﾂｨｪ06ｨｦ ｨｬｨ , ｨｮ09ｨｺ ｨｰ 05ｨｨｨｪ02ｨｦｨｪ04ｨｦ ｨｰ ｨｨ 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨ 09ｨｰ02 6 ｪ10 ｨｬ0209 ｨｮ ｨｬ040302ｨｦ, ｨｪ06ｨｺｨ ｨｮｨｰｨｪ ｨｪｨｮ irs2, ｨｨ09ｨｹ 0708ｨｨ04ｨｪｨ ｨｺｨｨ (Lin et al., 2004) ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ06 ｨｬｨｮｨｰｨ ｨｪｨｰｨｪ0402 ｨｬ0403ｨｨ ｨｨｨｬ0205ｨｨ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 ｨｬ02ｨｪｨｹ03ｨｨ02 08ｨ 04ｨｬ ｨｬ060400ｨ ｨｰ09ｨｨ02 09ｨｪｨｨ0302ｨｪｨｨ ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ, ｨｺ06ｨｰ0608ｨ ｨｮ05ｨｨ08ｨｮ02ｨｰ0907 ﾂ IRS2-04ｨ 09ｨｨ09ｨｨｨｬ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｮｨｰｨｨ ｨｨ070706ｨｺｨ ｨｬ0702 IRS ｨｨ02ｨｨｨｰｨｪ0401 ｨｬ040302ｨｦ 06ｨｰｨｬ02 ﾂｨ 05ｨｨ ｨｺｨｮ ｨｰｨｪ0609ｨｰｨｹ ｨｪ02ｨｦ080600ｨｨｨ 08ｨｨ ｨｪ0401 ｨｺ05ｨｮｨ ｨｺ0609, ｨ ｨｴｨｨ ｨｨ05ｨｨ080609ｨ ｨｪｨｪ ｨｬ04 Tau-ｨ 0205ｨｺｨ, ﾂｨｰ06 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ ｨｪ02ｨｦ ｨｪ0208ｨ ｨｰｨｨ09ｨｪ ｨ ｨ ｨ ｨｪｨｨｨｦ, 09 ｨｰ06ｨｬ ﾂｨｨ ｨ ｨｪｨｨ 0805ｨｹ020002ｨｦｨｬ0208ｨ (Schubert et al., 2003). 0308ｨｨ ﾂｨｨｨｪｨ 05ｨｰ ｨｰ06ｨｨｨｰ 09 09ｨｪｨｨ0302ｨｪｨｨｨｨ ｨｪ02ｨｦ ｨｰ02ｨｺｨｰ0608ｨｪ ｨｦ09ｨｰ09ｨｨ07 ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ ｨｨ ｨｪｨ 09ｨｰ08ｨｮｨｺｨｰｨｮ0804 ｨｬ060400ｨ, 0609ｨｮｨｴ0209ｨｰ ｨｬ ﾂ IRS2. 06ｨｬ0206ｨｰ ｨ ｨｪｨｪ ｨｰ06ｨｬ, ﾂｨｰ06 ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｬｨｨｨｺ ｨ 05ｨｨ02ｨｦ ﾂｨ 09ｨｰ06 06ｨ ｨｪｨ 08ｨｮ03ｨｨ09ｨ 06ｨｰ ｨｪｨｨ ｨｨ09ｨｰｨ 05ｨｹｨｪ06ｨｦ ﾂｨ 09ｨｰｨｨ ｨｬ060906ｨｬ04 13 (13q) 09ｨ 05ｨｨ04ｨｨ 0002ｨｪｨ irs2 ｨｬ020301ｨｮ ｨｬｨｨｨｺ080609ｨ ｨｰ020505ｨｨｨｰｨ ｨｬｨｨ D13S285 ｨｨ D13S1295, ｨ ｨ ｨｨ09ｨｰｨ 05ｨｹｨｪ ｨｨｨｨ ｨｬ020301ｨｮ ｨｬｨｨｨｺ080609ｨ ｨｰ020505ｨｨｨｰｨ ｨｬｨｨ D13S274 ｨｨ D13S ｨｰ0907 ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ ﾂ02ｨｰｨ ｨｪｨｪ04ｨｬｨｨ ｨｬｨｨｨｺ ｨ 05ｨｨ02ｨｦ ｨｨ ｨｺｨｰｨ ｨｬｨｨ ｨｬｨｨ080609ｨ ｨｪｨｨ07 ｨｪ020809ｨｪ06ｨｦ ｨｰ08ｨｮｨ ｨｺｨｨ (Luo et al., 2000). 06ｨｰ06 ｨｮｨｺｨ ｨ 02ｨｰ ｨｪｨ 09ｨ 03ｨｪｨｮ ｨｹ IRS2 ｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨｺｨ 09ｨｺｨ ｨｮ050702ｨｨｨｨ ｨｰｨ ｨｨ 01ｨｨ ｨｪ02ｨｨ080609ｨ ｨｪｨｨ07 ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 09 ｨｬ ﾂ ｨｺｨ ｨ ｨ 0502ｨｪｨｨ02 ｨｪｨｨ ｨ ｨｴｨｨ01 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨｺｨ 09ｨｺｨ , ｨｮ06 06 ﾂ ｨｹ PI3K ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ ｨｪｨｪ06ｨｦ 09 ｨｪ02ｨｦ AKT-ｨｺｨｨｨｪｨ 0404, ｨｰｨ ｨｺ ｨｪ0609ｨｨｨｰ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｦ 09ｨｺ05ｨ ｨ 0409ｨｨｨｰｨｨ ｨｨ ｨｪ02ｨｦ ｨｪ0208ｨ ｨｰｨｨ09ｨｪ ｨ ｨ ｨ ｨｪｨｨｨｦ, ｨ ｨｨｨｨ080609ｨ ｨｪｨｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ06 (O ｯNeill, 2013). 0201ｨｪｨ ｨｺ ｨｬ ｨｺ ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ ｨｺｨ 04ｨ ｨｰ0205ｨｹ09ｨｰ ｨｹ04ｨｮ 09ｨｪｨｨ0302ｨｪｨｨ07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ ｨｨｨｪ0604ｨｨｨｰｨｨ01ｨｪ ｨｮｨｰｨｨ 09 ｨｬ ｨｨ ｨｨｨ ｨ 02ｨｰ02 ｨｨ ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ07 ｨｪ ｨｮ ﾂ02ｨｪ ｨｰ ｨｬ07 ｨｨｨｬ0206ｨｰ0907 ｨｺ ｨｪｨｪ ｨ ｨｪｨｪ ｨ ｨｨｨｬ ｨｨ ｨｬ020301ｨｮ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬｨｨ 09 05ｨｰ06ｨｬ 07ｨｮｨｰｨｨ ｨｨ 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ, ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ ｨｮ050702ｨｨ07 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪ06ｨｬ ｨｮ ｨｪ ｨｬ020609ｨｰｨ 04ｨ 09ｨｺ0506 ﾂｨ 02ｨｰ ｨ ｨｨ00ｨｨ ﾂｨｪ ｨ ｨｪｨｨ02 09 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪ060904ｨｬｨｨ ｨｰ0608ｨ ｨｬｨｨ 09ｨｮ0708ｨ 01ｨｨｨ 04ｨｬｨ 05ｨｹｨｪ ｨ 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09ｨ, 06ｨｰ0902 ﾂｨ 06ｨｴ ｨ 0002ｨｪ0208ｨ 02ｨｨ06 02ｨｨ08ｨｺｨ 01ｨｪ ｨｨｨｰｨｬ0609, ｨｮ06ｨｴ02ｨｦ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ02ｨｦ 0604, IRS1 ｨｨ 04ｨ 09ｨｨ09ｨｨｨｬ ｨｰ ｨｪｨｨ01 ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ ｨｨｨｪ0604ｨｨｨｰｨｨ01ｨｪ ｨｮｨｰｨｨ (Anhe et al., 2004). 01ｨ 08ｨｮ0302ｨｪｨｨ02 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪ ｨｨ00ｨｪｨ 05ｨｨｨｪ00ｨ ｨｬ06ｨｴｨｹ06 ｨ ｨｪｨｰｨ 0006ｨｪｨｨ09ｨｰ0609 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪ ｨｰ ｨｨ ｨｰｨｨ ｨｨ05ｨｨ 0708ｨｨ ｨｨｨｪｨｰ08ｨ ｨ 08ｨ 05ｨｹｨｪ06ｨｬ ｨｪｨｨｨｨ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ PI3K 0708ｨｨ090601ｨｨ0506 ｨｺ 09ｨｪ07ｨｰｨｨ06 ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ06ｨｴ ｨｨ07ｨｪｨｨ07 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪｨ ｨｪｨ ｨｺ06ｨｪ ｨｪ ﾂ02ｨｪｨｨ ｨｨ ｨ ｨｪｨｨ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｰｨｺｨ ｨｪ02ｨｦ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ (Faria et al., 2013) ｨ 06ｨｨ ｨｮ ﾂｨ ｨｰｨｬ02 ﾂｨ 05ｨｨ 09ｨｪｨｨ0302ｨｪｨｨ ｨｨ05ｨｨ080609ｨ ｨｪｨｨ07 AKT-ｨｺｨｨｨｪｨ ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ ｨｺ ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ ｨｨ0906ｨｰｨｪ ｨｪｨｨ02 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪｨ, ｨｪｨ ｨｰｨｨ09, 09 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｨ05ｨｨ080609ｨ ｨｪｨｨ02 05ｨｰ ｨｬ02ｨｪｨｰｨ ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ06 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｮ080609ｨｪ07 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪｨ 06ｨｰｨｬ02 ﾂ02ｨｪ06 ｨｮ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ ﾂｨ 09ｨｰｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｨｨ ｨ 02ｨｰｨｨ- ﾂ0209ｨｺｨｨｨｬｨｨ ｨｰ0607ｨｪｨｨ07ｨｬｨｨ ｨｨ (Srinivasan et al., 2013) ｨｰ060006, ｨｮ01ｨ 0502ｨｪｨｨ02 ｨｮ ｨｺ ｨｨ03ｨｺ0609ｨｨ01ｨｪ06ｨｦ , ｨｮ02ｨｨ08ｨｮ06ｨｴ02ｨｦ ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪ, 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｮ09ｨｨ0502ｨｪｨｨ ｨｺ06ｨｪ ｨｪ0204ｨ ｨｨ ｨ 0409ｨｰ0806ｨｬｨｮ 08ｨ 0409ｨｨｨｰｨｨ06 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ 0702 ﾂ02ｨｪｨｨ, ｨｰ09ｨｨ02ｨｬ ﾂ ｨｰ ｨ 0409ｨｨｨｰｨｨ ｨｨｨ ｨ 02ｨｰｨ (Nogueira et al., 2011) ｨｮ ﾂ02ｨｪｨｪ ｨ ｨｪｨｪ0402 ｨｮｨｺｨ ｨ 06ｨｰ ｨｪｨ ｨｰ0209ｨｪｨｮ ｨ ｨｨｨｬ ｨｹ ｨｬ020301ｨｮ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬｨｨ 02ｨｨ08ｨｺｨ 01ｨｪ ｨｨｨｰｨｬｨ ｨｨ 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ, ｨｪ ﾂ ｨｨｨｰ ｨ ｨ 0502ｨｪｨｨ02 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｮｨｰ02ｨｦ 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ0902, ｨｮ05ｨｨ08ｨｮ06ｨｴｨｨ01 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ PI3K, ｨｨ 04ｨ 09ｨｨ09ｨｨｨｬ ｨｰ ｨｪ ｨｺｨｰ0608ｨｪ0401 ｨ 0205ｨｺ0609 ｨｨ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ ｨ ｨｺｨｰ (Lucassen et al., 2012). 0201ｨｪｨｨｨｬ ｨｨ , ｨｪｨ 0708ｨ ｨｪｨｪ0401 ｨｪｨ ｨｰｨ ｨｪ ｨｪｨｨ02 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ 09 ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022, ｨｰ ｨｪｨｨ02 ｨｮ080609ｨｪ07 ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ 09 ｨｬ ｨｰ09ｨｨ ｨｨｨｪｨｰ08ｨ ｨ 08ｨ 05ｨｹｨｪ ｨｨ05ｨｨ ｨｨｨｪｨｰ08ｨ ｨｪｨ 04ｨ 05ｨｹｨｪ ｨ ｨ ｨｪｨｨ07, 0708ｨｨ ﾂ02ｨｬ 09 ｨｰ06 ﾂｨｺｨｨ ｨｪｨｨ07 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺｨｨ ｨｨｨｪｨｰ08ｨ ｨｪｨ 04ｨ 05ｨｹｨｪ ｨｪｨｨ02 ｨ ﾂｨｰｨｨｨｰ0205ｨｹｨｪ06 (Subramanian, John, 2012; de la Monte, 2013; Novak et al., 2014). 01ｨ ｨｬｨｨ 0708ｨｨ 0105ｨｨｨｰ0205ｨｹｨｪ06ｨｬ 0502 ﾂ02ｨｪｨｨｨｨ ｨｺ ｨｪ0206ｨｪｨ ｨｰｨ 05ｨｹｨｪ06ｨｦ ｨｬ ｨｹ ｨｬ06ｨｴｨｹ06 ｨｨｨｪｨｰ08ｨ ｨｪｨ 04ｨ 05ｨｹｨｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ (09ｨｮｨｰ06 ﾂｨｪｨ ｨ ｨｪｨ ｨｺ080409ｨｮ) ｨ ｨｺｨ 04ｨ -

6 ｨ ｨｺ0609 ｨｪ06, ﾂｨｰ06 ｨｮ0302 ｨｪｨ ｨｪｨ ﾂｨ 05ｨｹｨｪ0401, ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ01, 09ｨｰｨ 01ｨｨ0701 ｨｮ 03ｨｨ0906ｨｰｨｪ ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 ｨｮ05ｨｮ ﾂ03ｨ 02ｨｰ ｨｨｨｺ02ｨｬｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｺ06ｨｪｨｰ080605ｨｹ, ﾂｨｰ ｨ 03ｨ ｨｹ 09 ｨｪ0608ｨｬｨ 05ｨｨ04ｨ 02ｨｨｨｨ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｰｨｺｨ ｨｪ02ｨｦ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ ｨｨ ｨｮ080609ｨｪ ｨｺ (Shpakov et al., 2012; 0107ｨ ｨｺ0609 ｨｨ 0108., 2013). 0308ｨｨ 05ｨｰ06ｨｬ ｨｪｨ ｨ ｨ 05ｨｨ ｨｰｨ ｨｪ ｨｪｨｨ ｨｬ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨ 0102ｨｪｨｨ05ｨ ｨｰ02ｨｨｨｺ05ｨ 04ｨｪ06ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 09 ｨｬ ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｺ080409, ｨｺ06ｨｰ0608ｨ ｨ 05ｨ 09ｨｹ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｬ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07ｨｬ 09 ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｺ0605ｨｹｨｺｨｮ ｨｨ04ｨｮ ﾂ02ｨｪｨｪ0402 ｨｪｨ ｨｬｨｨ ｨｬ06ｨｪ04, ｨｮ0507ｨｰ ｨ 0102ｨｪｨｨ05ｨ ｨｰ02ｨｨｨｺ05ｨ 04ｨｪ06ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04, ｨｰｨ ｨｺｨｨ02 ｨｺｨ ｨｺ ｨｰ06ｨｪｨｨｨｪ, ｨ ｨｬｨｨｨｪ, ｨｪ0608ｨ ｨｪｨ 05ｨｨｨｪ, 0906ｨｬｨ ｨｰ0609ｨｰｨ ｨｰｨｨｨｪ ｨｨ ｨ ｨｺ09ｨｨｨｪ, ｨｪ ｨｰ0902ｨｪｨｪ ﾂ02ｨｪ ｨｮ050702ｨｨ06 00ｨｮｨｪｨｺ02ｨｨｨｦ , 05ｨｪ0106ｨｺ08ｨｨｨｪｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04, 05ｨｪ ｨｰｨｨ ﾂ0209ｨｺ ｨ ｨｬ02ｨｪｨ, 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ06ｨｦ ｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ, ｨｰｨ ｨｪ ｨｪｨｨ ｨｮ05ｨｨ08ｨｮ02ｨｬ0401 ｨｨｨｬｨｨ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨｺｨ 09ｨｺｨ ｨｬ ｨｬ06ｨｴｨｹ ｨｨｨｰ0205ｨｹｨｪ ﾂ02ｨｪｨｨ07 01ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｺ ｨｨｨｪｨｰ08ｨ ｨｪｨ 04ｨ 05ｨｹｨｪ04ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ ｨｰ ｨｮ ｨｨｨｰｨｹ 03ｨｨ0806ｨｺｨｨｨｦ ｨｺｨｰ08 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｨ ｨｪ02ｨｪｨｨｨｦ, ｨ ｨｨｨｨ080609ｨ ｨｪｨｪ ｨｨｨ ｨ 02ｨｰ06ｨｬ ｨｨ ｨｰ08ｨ 02ｨｨ02ｨｦ 05ｨｰ ｨｰ0907 ｨｰ06ｨｰ 00ｨ ｨｺｨｰ, ﾂｨｰ ﾂ02ｨｪｨｨ02 ｨｨｨｪｨｰ08ｨ ｨｪｨ 04ｨ 05ｨｹｨｪ04ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ 09 04ｨｪｨ - ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ 02ｨｰ ｨｺ0600ｨｪｨｨｨｰｨｨ09ｨｪ ｨｮｨｪｨｺ02ｨｨｨｨ ( ｨｰ08ｨ ｨｪ09ｨｰ0902ｨｪｨｪｨｮ06 07ｨ ｨｬ07ｨｰｨｹ, ｨ ｨｪ0609ｨｰｨｹ ｨｺ 06ｨ ｨｮ ﾂ02ｨｪｨｨ06) ｨｮ ｨｺ (05ｨｮ ｨｨ 0108., 2013). 0709ｨｰｨ ｨｪ ｨｪ06 ｨｰｨ ｨｺ0302, ﾂｨｰ06 ｨｨｨｪｨｰ08ｨ ｨｪｨ 04ｨ 05ｨｹｨｪ04ｨｦ ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨ ｨｰ 05ｨｨ070605ｨｨ04 09 ｨ ｨｦ 03ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ, ｨｪ ﾂ ｨｨｨｰ ｨｪｨｨ02 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨ 01ｨｨ070602ｨｨｨｰ0609 ｨｺ 0102ｨｦ09ｨｰ09ｨｨ06 ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ, ﾂｨｰ ｨｰ ｨｺ ｨｪ0608ｨｬｨ 05ｨｨ04ｨ 02ｨｨｨｨ 05ｨｨ07ｨｨ01ｨｪ ｨ ｨｬ02ｨｪｨ ｨｨ 09ｨｪｨｨ0302ｨｪｨｨ06 05ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ ｨｨ ｨ ｨｪ06, ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, ｨｰ0908ｨ ｨｰｨｨｨｰｨｹ ｨｨｨ ｨ 02ｨｰｨ ｨｪ04ｨｦ (Iwen et al., 2014). 08ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｰ0607ｨｪｨｨ ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ 09 ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｰｨｨｨｪ, ｨｮｨｺｨｰ 0002ｨｪｨ ob, 0902ｨｺ0802ｨｰｨｨ08ｨｮ02ｨｬ04ｨｦ ｨｨｨｬｨｮｨｴ0209ｨｰ0902ｨｪｨｪ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨ 01ｨｨ070602ｨｨｨｰｨ ｨｬｨｨ, ｨｮ05ｨｨ08ｨｮ02ｨｰ 05ｨｪ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬ ｨｨ ｨｬｨ 0909ｨｮ ｨｰ0205ｨ ｨｨ02ｨｨｨｰ ｨｮ ﾂ ｨｺｨ ｨｨ 05ｨｺ ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ ｨｨ0906ｨｰｨｪ ｨｨ090601ｨｨｨｰ ｨｺ ｨｰ ｨｬ ｨｬｨ ｨｬ 0603ｨｨ0802ｨｪｨｨ ｨｰｨｨｨｪ ｨｪｨｨｨｺｨ 02ｨｰ 09 ｨｬ ﾂ ｨｬｨ ｨｰ0605ｨｪ020200ｨ 05ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨ ｨ 08ｨｹ ｨｰ09ｨｨ ｨｰ ｨｮ02ｨｬ ｨｪ010602ｨｨｨｰ0604ｨ. 06ｨ ｨｬ 06ｨｪ ｨ 02ｨｰ ｨｰ0608ｨ ｨｬｨｨ ｨｰｨｨｨｪｨ, 0506ｨｺｨ 05ｨｨ040609ｨ ｨｪｨｪ04ｨｬｨｨ 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪｨ 01, ｨｺ06ｨｰ ｨ 08ｨ ｨｺｨｰ0208ｨｪｨ ｨｺｨ 07 ｨｨ ｨｰｨｪ0609ｨｰｨｹ, ｨ ｨｰｨ ｨｺ ｨｰ0608ｨ ｨｬｨｨ ｨｰｨｨｨｪｨ, 08ｨ ｨｪｨｪ04ｨｬｨｨ ｨｮ00ｨｨ01 06ｨｰ010205ｨ 01 ｨｬ060400ｨ ｪ ｨｺ060802, ｨｰｨ 05ｨ ｨｬｨｮ0902, ｨｬ ﾂｨｺ02, 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ ｨｮｨｺ0609ｨｨ02ｨ 01 ｨｨ ｨｮ01ｨｨ09ｨｰ06ｨｬ ｨｰ02ｨｪｨｨｨｨ (Mutze et al., 2006; Marino et al., 2011) ｨｰｨｨｨｪ ｨｰ ｨｰｨｪ060907ｨｰ0907 ｨｺ 0902ｨｬ02ｨｦ09ｨｰ09ｨｮ 02ｨｨｨｰ06ｨｺｨｨｨｪ ｨｰ ｨｨ ｨｨｨｬ0206ｨｰ ｨｪ0209ｨｺ0605ｨｹｨｺ06 ｨｨ ｨｬ, ｨｪ06 ｨｰ0605ｨｹｨｺ ｨｪ0608ｨ 04ｨｬ0208ｨｪｨ ｨｬｨ ｨｰ0608ｨ ｨｰ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨ ｨｺｨｰｨｨ09ｨｪ06ｨｦ ｨｨ ｨ ｨｪｨ ｨ 09ｨ ｨｰｨｹ 09ｨｨ00ｨｪｨ ｨｺ0502ｨｰｨｺｨｮ. 08ｨｺｨｰｨｨ09ｨ 02ｨｨ ｨｬ06ｨｪ06ｨｬ ｨｰｨｨｨｪ ｨｰ0608ｨ 0708ｨｨ090601ｨｨｨｰ ｨｺ 09ｨｰｨｨｨｬｨｮ050702ｨｨｨｨ ｨｪ ｨｰ0608ｨｪ06ｨｦ ｨｰｨｨ080604ｨｨｨｪｨｺｨｨｨｪｨ 0404 JAK2, ｨｺ06ｨｰ0608ｨ ｨｨ05ｨｨ08ｨｮ02ｨｰ 09ｨｪｨｮｨｰ08ｨｨｨｺ0502ｨｰ06 ﾂｨｪ04ｨｦ 0106ｨｬ02ｨｪ ｨｰ0608ｨ ｨｨ 06ｨ ﾂｨｨ09ｨ 02ｨｰ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ02 09 IRS-ｨ 0205ｨｺｨ ｨｬｨｨ ｨｨ 01ｨ 05ｨｹｨｪ02ｨｦ03ｨｮ06 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06 PI3K ｨｨ ｨｺｨ 09ｨｺｨ 01ｨ ｨｬｨｨｨｰ060002ｨｪｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04 (Hegyi et al., 2004). 06ｨｨ080604ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ JAK2 ｨｰｨ ｨｺ0302 ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｰ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ04ｨｦ 00ｨ ｨｺｨｰ0608 STAT3, ｨｺ06ｨｰ060804ｨｦ ｨｨ05ｨｨ080609ｨ ｨｪｨｨ ｨ 02ｨｰ ｨｬ0601ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ, ｨｰ08ｨ ｨｪ ｨｨ08ｨｮ02ｨｰ ｨｨ ｨｮ05ｨｨ08ｨｮ02ｨｰ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ STAT3-04ｨ 09ｨｨ09ｨｨｨｬ ｨｪ0609 (Mutze et al., 2006; Sahu et al., 2011) (08ｨｨ09. 2) ｨｺ0605ｨｹｨｺｨｮ IRS-ｨ 0205ｨｺｨｨ ｨｨ ｨｪｨｨ ｨ ｨｴｨｨｨｦ ｨｨｨｪ0604ｨｨｨｰｨｨ01ｨｪ04ｨｦ ｨｺｨ 09ｨｺｨ ｨｰ ｨ 03ｨｪ02ｨｦ03ｨｨｨｬｨｨ ｨ 0506ｨｺｨ ｨｬｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｨ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬ, 06ｨｪｨｨ ｨｨ 06ｨ ﾂｨｨ09ｨ 06ｨｰ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ02 ｨｬ020301ｨｮ ｨｪｨｨｨｬｨｨ ｨｨ ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ06ｨｦ ｨｺｨ ｨｺ 09 ｨｪ0608ｨｬ02, ｨｰｨ ｨｺ ｨｨ 09 ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 07ｨ ｨｰ ｨｨｨｨ ｨｰｨｨｨｪ ｨｬ060400ｨ 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ02ｨｰ ｨｰ08ｨｮｨｺｨｰｨｮ08ｨ ｨｬｨｨ 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09ｨ ｨｨ ｨｮ05ｨｨ08ｨｮ02ｨｰ 08ｨ ｨｪ020800ｨｨｨｨ ｨｨ 0706ｨｰ0802ｨ 0502ｨｪｨｨ02 07ｨｨｨｴｨｨ, 0609ｨｮｨｴ0209ｨｰ ｨｺ06ｨｪｨｰ080605ｨｹ 09ｨｨｨｪｨｰ0204ｨ ｨｨ 0902ｨｺ080202ｨｨｨｨ ｨｪ02ｨｦ ｨｰｨｨ01ｨ Y, ｨ ｨｰｨ ｨｺ0302 a-ｨｬ0205ｨ ｨｪ0602ｨｨｨｰ09ｨｰｨｨｨｬｨｮ05ｨｨ08ｨｮ06ｨｴ ｨｬ06ｨｪｨ (a ) ｨｨ ｨ 00ｨｮｨｰｨｨ ｨ ｨｪ ｨｰｨｨ01ｨ ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06 ｨ 0006ｨｪｨｨ09ｨｰｨ ｨｨ ｨ ｨｪｨｰｨ 0006ｨｪｨｨ09ｨｰｨ ｨｬ0205ｨ ｨｪ06ｨｺ0608ｨｰｨｨｨｪ ｨｰ ｨｨ ｨｰｨｨ (Schwartz et al., 2000; Signore et al., 2008; Williams et al., 2011). 01ｨ 08ｨｮ0302ｨｪｨｨ02 05ｨｰ ｨｺ06ｨｪｨｰ ｨｨ090601ｨｨｨｰ ｨｺ 00ｨｨ ｨ 00ｨｨｨｨ, 0603ｨｨ0802ｨｪｨｨ06 ｨｨ 08ｨ 0409ｨｨｨｰｨｨ ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｰ0607ｨｪｨｨｨｦ ｨｰｨｨｨｪ, ｨｺｨ ｨｺ ｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ, ｨｮ05ｨｨ08ｨｮ02ｨｰ ｨ ｨｮ01ｨｨｨｬ0609ｨｰｨｹ 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪ0609, ｨｬ0601ｨｮ05ｨｨ08ｨｮ02ｨｰ 09ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺｨｮ ｨ 09ｨｰｨｨ ﾂｨｪ0609ｨｰｨｹ, ｨｮ ﾂｨ 09ｨｰ09ｨｮ02ｨｰ ｨ 01 06ｨ ｨｮ ﾂ02ｨｪｨｨ07 ｨｨ ｨｬｨｨ080609ｨ ｨｪｨｨ07 07ｨ ｨｬ07ｨｰｨｨ. 02ｨｪ 06ｨ ﾂｨ 02ｨｰ ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺ ｨ ｨｪｨｨ02 ｨｪ02ｨｦ0806ｨｰ08ｨ ｨｪ09ｨｬｨｨｨｰｨｰ ｨｨ ｨ 02ｨｰ ｨｰ09ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺｨｮ06 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨｺ ｨｪｨｨｨｬ 09 ｨｪ02ｨｦ0806ｨｪｨ 01 00ｨｨ070706ｨｺｨ ｨｬ07ｨ, ｨ ｨｰｨ ｨｺ ｨｮ05ｨｨ08ｨｮ02ｨｰ 00ｨｨ070706ｨｺｨ ｨｬ07ｨ 05ｨｹｨｪｨｮ06 09ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺｨｮ ｨ 09ｨｰｨｨ ﾂｨｪ0609ｨｰｨｹ ｨｮｨｪ04 09 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬｨｨ ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ ｨｬ06ｨｪ09ｨｰ08ｨｨ08ｨｮ06ｨｰ 09ｨｪｨｨ0302ｨｪｨｨ02 00ｨｨ070706ｨｺｨ ｨｬ07ｨ 05ｨｹｨｪ06ｨｦ 09ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 0705ｨ 09ｨｰｨｨ ﾂｨｪ0609ｨｰｨｨ, 0708ｨｨ ﾂ02ｨｬ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨ ｨｰｨｨｨｪ06ｨｬ ｨｪ0609ｨｰｨｹ ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ 02ｨｰ 00ｨｮｨｪｨｺ02ｨｨｨｨ 00ｨｨ070706ｨｺｨ ｨｬ07ｨ (Li et al., 2002) ｨｪ ﾂ0209ｨｺｨｨ02 05ｨｺ ｨｨｨｬ02ｨｪｨｰ ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 09 ｨｪｨｨ04ｨｺｨｨ01 00ｨｨ04ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｰｨｨｨｪ ｨｮ05ｨｮ ﾂ03ｨ 02ｨｰ ｨｰ08ｨ ｨｪ09ｨｰ0902ｨｪｨｪ ｨ ｨｮ ﾂ02ｨｪｨｨ02 ｨｨ ｨｬ02ｨｪｨｪ ｨｰ02ｨｪ02ｨｨ080609ｨ ｨｪｨｨ02, 09 ｨｰ ｨｬ07 ｨｺｨ ｨｺ ｨｺｨｨ ｨｬ06ｨｪｨ, ｨｪｨ ｨｰｨｨ09, ｨｮ01ｨｮ0103ｨ 06ｨｰ 05ｨｰｨｨ 0706ｨｺｨ 04ｨ ｨｰ0205ｨｨ (Oomura et al., 2011) ｨｰｨｨｨｪ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨｨ08ｨｮ02ｨｰ 09 ｨｪ02ｨｦ0806ｨｪｨ 01, ｨｺｨ ｨｺ ｨ ｨｪｨｰｨｨｨ ｨｰ06ｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ 00ｨ ｨｺｨｰ0608, ｨｨ ｨｦ09ｨｰ09ｨｨ ｨ 05ｨｨ04ｨｮ02ｨｰ ｨｪ0209ｨｺ0605ｨｹｨｺｨｨｨｬ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ04ｨｬ 07ｨｮｨｰ07ｨｬ, ｨｴｨｮ ｨｹ ｨｨ ｨｺ06ｨｰ ｨｨ0008ｨ 02ｨｰ ｨｨｨｪ0604ｨｨｨｰｨｨ01ｨｪ04ｨｦ 07ｨｮｨｰｨｹ, 09ｨｺ0506 ﾂｨ 06ｨｴｨｨｨｦ ｨ 07 PI3K ｨｨ AKT-ｨｺｨｨｨｪｨ 04ｨｮ (Morton et al., 2005) (08ｨｨ09. 2) ｨｰｨｨｨｪ ｨｰｨ ｨｺ ｨｰ0907 ｨｪ02ｨｦ0806ｨｰ080600ｨｨ ﾂ0209ｨｺｨｨｨｬ 00ｨ ｨｺｨｰ060806ｨｬ, ｨｪｨ ﾂｨｰ06 ｨｮｨｺｨ ｨ 02ｨｰ ｨ ｨｪ0609ｨｰｨｹ ｨｰ0908ｨ ｨｴｨ ｨｰｨｹ ｨ 01ｨ 02ｨｨ ｨ ｨｬｨｨｨｪ020800ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪ0609, ｨ ｨｪｨｪｨｮ ｨｦ09ｨｰ09ｨｨ02ｨｬ ｨｰ06ｨｺ09ｨｨｨｪ0609, ｨｨ ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ ｨｰｨｹ ｨｪ ﾂ0209ｨｺｨｨ ｨ ｨｺ02ｨｨｨｨ, ｨｪｨ 08ｨｮ0302ｨｪｨｪ ｨｮ ｨｨ0701 ｨｨｨｪｨｰ06ｨｺ09ｨｨｨｺｨ 02ｨｨｨｨ (Weng et al., 2007) ｨ ｨｰ0205ｨｹｨｪ06, ｨｰｨｨｨｪ ｨｪ02 ｨｰ0605ｨｹｨｺ06 04ｨ ｨｴｨｨｨｴｨ 02ｨｰ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 06ｨｰ ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ, ｨｪ06 ｨｨ ｨｰ0908ｨ ｨｴｨ 02ｨｰ ｨｪｨ 08ｨｮ0302ｨｪｨｨ ｨｨ00ｨｪｨ 05ｨｹｨｪ ｨｨ09ｨｰ02ｨｬｨ 01 ｨｬ060400ｨ, ｨｮ05ｨｨ08ｨｮ02ｨｬ ｨ ｨｬｨｨｨｪ06ｨｬ ｨｨ 0108ｨｮ00ｨｨｨｬｨｨ ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨ ｨｬｨｨ, ﾂｨｰ06 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｨ ｨｹ040609ｨ ｨｪ ｨｮ ｨｪｨｨ07 08ｨ 0409ｨｨｨｰｨｨ07 ｨｪ02ｨｦ ｨｪ0208ｨ ｨｰｨｨ09ｨｪ ｨｮ ｨｨ ｨｨｨ ｨ 02ｨｰｨ ｨｨ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｮ ｨｺ Zucker fa/fa ｨｨ ｨｬ040302ｨｦ db/db ｨｨ02ｨｨｨｰ06ｨｬ ｨｰｨｨｨｪ ｨｰ0608ｨ ｨｨｨｬ0206ｨｰ0907 ｨｪｨ 08ｨｮ0302ｨｪｨｨ ｨｨ070706ｨｺｨ ｨｬ07ｨ 05ｨｹｨｪ06ｨｦ ｨｬ02ｨｪｨｪ06ｨｦ 0706ｨｰ02ｨｪ02ｨｨｨ 02ｨｨｨｨ ｨｨ 08ｨ 0409ｨｨｨｰｨｨ ｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｨｨｨ (Li et al., 2002; Ramos-Rodriguez et al., 2014). 07 ｨｪｨｨ ｨｪｨ ｨｪ ｨｰｨ ｨｰ06 ﾂｨｪ0609ｨｰｨｹ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｨ ｨｪ ﾂ0209ｨｺ06ｨｦ 0705ｨ 09ｨｰｨｨ ﾂｨｪ0609ｨｰｨｨ, 0708ｨｨ- ﾂ02ｨｬ ｨｪｨｨ ｨｰｨｨｨｪｨ ｨｪ02 ｨｮ09ｨｰ08ｨ ｨｪ0702ｨｰ 05ｨｰｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ ｨｰ09ｨｨ02 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ ｨｪ090608ｨｪ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰｨ ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ ｨｮ ｨｨ ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ07 09ｨ ｨｬ ｨｰｨｨｨｪｨ ｨｮ ｨｬｨｮｨｰｨ ｨｪｨｰｨｪ0401 Lep ob/ob -ｨｬ040302ｨｦ ｨｨ0802ｨｪｨｨ02ｨｬ 09ｨｪｨｨ03ｨ 02ｨｰ0907 ｨｺｨ ｨｺ ｨ ｨｪｨｨ ｨ ｨｬｨｨｨｪｨ ｨｨｨｺｨｮ05ｨ 01 ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ, ｨｰｨ ｨｺ ｨｨ ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨ ｨ 02ｨｬ ｨｨ04 ｨｪｨｨ01 ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨ (Roseberry et al., 2007). 06ｨｰ ｨ ｨｪ06 09 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02ｨｬ ﾂｨｨ0905ｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨ ｨｺｨｰｨｨ09ｨｪ0401 ｨｰ08ｨ ｨｪ ｨｰ ｨ ｨｬｨｨｨｪｨ, ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｮ ｨｪｨｹ ｨ ｨｬｨｨｨｪｨ 09 09ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｴ0205ｨｨ. 06ｨｪｨｰ08ｨ ｨ 08ｨ 05ｨｹｨｪ ｨｪｨｨ ｨｰｨｨｨｪｨ MCR-ｨｬ0403ｨ ｨｬ, ｨｺ06ｨｰ ｨｨｨｬ0206ｨｰ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨｪ02ｨ ｨｺｨｰｨｨ09ｨｪ04ｨｦ ｨｺ020502ｨｰｨｪ0401 ｨｬ040302ｨ 01 ｨｨ 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ06ｨｰ ｨｨ ｨｨｨｺ02ｨｬｨｨ02ｨｦ, 00ｨｨ070208ｨｨｨｪ09ｨｮ05ｨｨｨｪ02ｨｬｨｨ02ｨｦ ｨｨ 01ｨｨ0905ｨｨ07ｨｨ0102ｨｬｨｨ02ｨｦ,