Kongress_1-223.pmd

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1 ｨｨ ｨｪｨｨ PROBLEMS OF PUBLIC HEALTH ORGANIZATION AND INFORMATIZATION ISSN ｨｪ04ｨｨ08ｨｮ02ｨｬ04ｨｦ ｨ ｨｪｨ 05ｨｨｨｰｨｨｨｺ06-ｨｨｨｪ000608ｨｬｨ 02ｨｨ06ｨｪｨｪ04ｨｦ ｨ ｨｰ02ｨｪｨｹ 00ｨｨｨｪｨｨ09ｨｰ020809ｨｰ ｨ ｨ ｨｪ02ｨｪｨｨ ｨｮｨ 05ｨｨｨｺｨｨ ｨ 08ｨｮ09ｨｹ t ｨ 02ｨｰ ｨｮｨ 05ｨｨｨｺｨ ｨｪ09ｨｺｨｨｨｬ ｨｪｨ ｨｮ ﾂｨｪ ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨｨｨｬ 0202ｨｪｨｰ0806ｨｬ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ ｨｨｨｦ, ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ, ｨｮ0708ｨ ｨｪｨｨ07 ｨｨ 05ｨｺ06ｨｪ06ｨｬｨｨｨｺｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ , ｨｨｨｰ 4 08ｨ 04ｨ ｨ 09ｨｪ04ｨｦ ｨ ｨｺｨｰ ﾁ ｨ ｨｺ02ｨｨ06ｨｪｨｪｨ 07 ｨｺ ｨｨ07: ｨ 05ｨｹ ﾂｨｮｨｺ ｨ ｨｺｨｨｨｦ ｨｮ03ｨ ｨｪｨｺ ｨ ｨｺ0609ｨｨ ﾂ ｨ 08ｨｺ ｨ 07ｨｨ02ｨｺｨｨｨｦ ｨｨ07ｨｪｨｨ02ｨｺｨｨｨｦ ｨｨ02ｨｺｨｨｨｦ ｨ 05ｨ ｨ (04ｨ ｨｬ ｨ 09ｨｪ ｨ ｨｺｨｰ0608ｨ ) ﾂ02ｨｺ ｨｨ05ｨｨ ｨｨ ﾂ ｨｨｨｪ0209ｨｨ ﾂ ｨｺ ｨｬ04 ﾂ02ｨｺ ( ｨ ｨｰ0205ｨｹ ｨ ｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｺ ｨｨｨｨ) ｨｨｨｴ02ｨｪｨｺ ｨｦ (06ｨｰ ｨｺ0802ｨｰｨ 08ｨｹ) ﾁｨ 09ｨｪ06ｨｦｨｰｨｹ ｨ 0803ｨ ｨｺ0609ｨ ﾂｨｮｨｺ ｨｨ ｨ ｨｺ02ｨｨｨｨ: , ｨｨｨｪ09ｨｺ, ｨｮ ｨｺｨｨ, 7ｨ 09ｨ ｨ 0608ｨ ｨｰ0608ｨｨ ｨｪ ｨｰｨ ｨｪ01ｨ 08ｨｰｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｪｨｺｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ ｨｨｨｦ (017) ; infomed@belcmt1 7by ｨｮｨ 05ｨｨｨｺｨ ｨｪ09ｨｺｨｨｨｦ ｨｪｨ ｨｮ ﾂｨｪ ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ 0202ｨｪｨｰ08 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ ｨｨｨｦ, ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ, ｨｮ0708ｨ ｨｪｨｨ07 ｨｨ 05ｨｺ06ｨｪ06ｨｬｨｨｨｺｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ07 00ｨｨｨｪ040108ｨ 09ｨ ｨｮｨ 05ｨｨｨｺｨｨ ｨ 08ｨｮ09ｨｹ ( ), 2016

2 1300ｨ ｨｰ0208ｨｨｨ 0504 III ｨ 04ｨｨｨｦ09ｨｺ ｨｺ06ｨｪ ｨ ｨｬｨ ｨｰ ｨｨｨｪ09ｨｺ, ｨｮｨ 05ｨｨｨｺｨ ｨ 08ｨｮ09ｨｹ, 26ｨC27 ｨｬｨ ｨ 01ｨｮｨ 04ｨｨ040609ｨ 06ｨ 03ｨｺ02ｨｪｨｰ09ｨｺｨ 07 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨ 07 ｨ ｨｺｨ 0102ｨｬｨｨ07, ｨ 03ｨｺ02ｨｪｨｰ, ｨｮｨ 05ｨｨｨｺｨ 0704ｨ 02ｨｺｨｨ09ｨｰｨ ｨｪ ｨｨ 09ｨｪ0209ｨｮ09ｨｰｨ 09ｨｪ ｨｪｨｨｨｦ ｨｬｨ ｨｰ06ｨｨ01ｨｪ ｨ 08ｨｰ08ｨｨｨｰｨ 09ｨ 03ｨｪ0602 ｨｬ0209ｨｰ06 04ｨ ｨｪｨｨｨｬｨ 06ｨｰ ｨ 0302ｨｪｨｨ ｨｺｨｨ ｨｮ ﾂ02ｨｪｨｨ02 ｨｺ05ｨｨｨｪｨｨｨｺ06-00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｺｨｨ01, ｨｪｨｨ02 ｨｬｨｮ05ｨｹｨｰｨｨ0907ｨｨ08ｨ 05ｨｹｨｪ06ｨｦ ｨｺ06ｨｬ07ｨｹ06ｨｰ0208ｨｪ06ｨｦ ｨｰ06ｨｬ060008ｨ 00ｨｨｨｨ ｨｨ ｨｬ06ｨｪｨｨｨｰ0608ｨｨｨｪ ｨｨ ｨ ｨｪｨｨ02 ｨ 0806ｨｪ01ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｨｨｬ0609ｨｰｨｨ ｨｮ ｨ 0605ｨｹｨｪ ｨｬｨ ｨｰ06ｨｨ01ｨｪ06ｨｬ ｨ 08ｨｰ08ｨｨｨｰ06ｨｬ ｨｰ ｨｬ02ｨｪｨｪ06 09ｨｪ0609ｨｨｨｰｨｹ ｨｺ ｨｺｨｰｨｨ ﾂ02ｨｪｨｨ ﾂ ｨ : ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ, 01ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨ, ｨｬｨｮ05ｨｹｨｰｨｨ0907ｨｨ08ｨ 05ｨｹｨｪｨ 07 ｨｺ06ｨｬ07ｨｹ06ｨｰ0208ｨｪｨ 07 ｨｰ06ｨｬ060008ｨ 00ｨｨ07, 0907ｨｨ0806ｨｬ02ｨｰ08ｨｨ ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ (0408) ｨC 0601ｨｪ06 ｨｨ04 ｨｪｨ ｨｨｨ ｨ ｨｰ08ｨ ｨｪ02ｨｪｨｪ ｨ 05ｨｨｨｰ0205ｨｹｨｪ ｨ ｨ ｨ ｨｪｨｨｨｦ 09ｨｮ09ｨｰｨ , ｨｮ050702ｨｨｨｨ ﾂｨ 09ｨｰ06ｨｰｨ 01ｨ ｨｪｨｪ06ｨｦ 07ｨ ｨｰ ｨｨｨｨ ｨｰｨ ｨｰ 1ｨC2% ｨ 08ｨ ｨｺｨｰ0208ｨｪ ｨｨ08ｨｮ06ｨｴ0202 ｨｰ02 ﾂ02ｨｪｨｨ ｨｬｨｨ080609ｨ ｨｪｨｨ02ｨｬ ｨｬｨ 02ｨｨｨｦ 09ｨｮ09ｨｰｨ , 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｰ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｨ ｨ 0302ｨｪｨｨ02ｨｬ 09ｨｪｨｮｨｰ0802ｨｪｨｪｨｨ ｨ ｨｪ0609, 08ｨ ｨｪｨｪ02ｨｦ ｨｨｨｪ09ｨ 05ｨｨ01ｨｨ04ｨ 02ｨｨ02ｨｦ ｨ 0605ｨｹｨｪ0401, 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ02ｨｬ ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 03ｨｨ04ｨｪｨｨ [1, 3, 4] ｨｪ0609ｨｮ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ ｨｪｨｨｨｦ ｨｰｨ ｨｰ 09ｨｨｨｬｨｬ02ｨｰ08ｨｨ ﾂｨｪ04ｨｦ ｨｪｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｨ09ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 09ｨｮ09ｨｰｨ ｨｪｨ ｨｺ06, 0708ｨｨ 05ｨｰ06ｨｬ 04ｨ ｨ ｨ ｨｪｨｨｨｨ ﾂｨ 09ｨｰ ｨｰ0802 ﾂｨ 06ｨｰ0907 ｨｨ 09ｨｨ09ｨｰ02ｨｬｨｪ ｨ 05ｨｨｨｰ0205ｨｹｨｪ ｨ 0302ｨｪｨｨ07 09ｨｪｨｮｨｰ0802ｨｪｨｪｨｨ ｨ ｨｪ ｨｪｨｨ ｨｬ0600ｨｮｨｰ 09ｨｰｨ ｨｰｨｹ 0708ｨｨ ﾂｨｨｨｪ06ｨｦ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ ｨｪｨｨ0302ｨｪｨｨ07 ｨｺｨ ﾂ0209ｨｰ09ｨ 03ｨｨ04ｨｪｨｨ, ｨｰ08ｨｮ ｨ ｨｪ0609ｨｰｨｨ ｨｨ 09 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｬ ｨｰｨｹ ｨｪ0604 [2, 6, 7] ｨｨ 09ｨｪ0209ｨｮ09ｨｰｨ 09ｨｪ ｨｪｨｨｨｦ ｨ 03ｨｪ0602 ｨｬ0209ｨｰ06 04ｨ ｨｪｨｨｨｬｨ 06ｨｰ ｨ 0302ｨｪｨｨ ｨｺｨｨ01 ｨｨ ｨｪｨｨ03ｨｪｨｨ ｨ ｨｰ0205ｨｹｨｪ ｨｮｨｰ02ｨｦ ｨｬｨｨ ｨｦ 05ｨｨｨｰ0208ｨ ｨｰｨｮ0802 ｨｪｨ ｨｺ ｨｪ ｨｪ02ｨｬｨ 0504ｨｦ 06ｨ ｨｲ02ｨｬ ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ ｨ 0302ｨｪｨｨｨｨ ｨ ｨｪ ｨ ｨｪｨｨ ｨｨ 0408 [8ｨC10], 0601ｨｪｨ ｨｺ ｨｰ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ 0609ｨｰｨ 02ｨｰ ｨｪ ｨｪｨｪ ｨ 0502ｨｬ1 7 01ｨｮ0301ｨ 02ｨｰ ｨｮｨｰ06 ﾂｨｪ02ｨｪｨｨｨｨ ﾂｨ 09ｨｰ06ｨｰｨ ｨ 0806ｨｪ ﾂｨｪ ｨ 0302ｨｪｨｨｨｦ ｨｮ ｨ 0605ｨｹｨｪ ｨｹ ｨｨ ｨ ｨｪｨｨ07 ｨC ｨｨ04ｨｮ ﾂ02ｨｪｨｨ02 01ｨ 08ｨ ｨｺｨｰ0208ｨ ｨｨ 08ｨ ｨｰ08ｨ ｨｪ02ｨｪｨｪ0609ｨｰｨｨ ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ ｨ ｨｰ0205ｨｹｨｪ ｨｮｨｰ02ｨｦ ｨｮ ｨ 0605ｨｹｨｪ ｨ ｨｰ0208ｨｨｨ 0504 ｨｨ ｨｬ02ｨｰ ｨｹ06 ｨｨ04ｨｮ ﾂ02ｨｪｨｨ07 01ｨ 08ｨ ｨｺｨｰ0208ｨ ｨｨ 08ｨ ｨｰ08ｨ ｨｪ02ｨｪｨｪ0609ｨｰｨｨ ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ ｨ ｨｰ0205ｨｹｨｪ ｨｮｨｰ02ｨｦ ｨｮ ｨ 0605ｨｹｨｪ ｨｪ06 ｨｺ06ｨｬ070502ｨｺ09ｨｪ0602 ｨｺ05ｨｨｨｪｨｨｨｺ06-ｨｨｨｪ09ｨｰ08ｨｮｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ ｨ ｨ ｨｪｨｨ02 98 ｨ 0605ｨｹｨｪ0401 (ｨｨ04 ｨｪｨｨ01: 12 ｨｬｨｮ03 ﾂｨｨｨｪ ｨｨ ｨｪｨｴｨｨｨｪ) ｨｰ ｨｪ04ｨｬ 01ｨｨｨ 00ｨｪ060406ｨｬ 0408 ｨｪｨ 0609ｨｪ0609ｨ ｨｪｨｨｨｨ ｨｺ08ｨｨｨｰ0208ｨｨ ｨｬ0208ｨｨｨｺｨ ｨｪ09ｨｺ06ｨｦ ｨｬｨ ｨｰ ｨｨ ﾂ0209ｨｺ06ｨｦ ｨ ｨｨｨ 02ｨｨｨｨ ｨｪ ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 04ｨ ｨ ｨ ｨｪｨｨ ｨｰｨ 09ｨｨ05ｨ 10,5 ﾀ8,6 0502ｨｰ ｨｨｨｰｨｨ09ｨｪ04ｨｦ 0408 ｨｨｨｬ0205 ｨｬ0209ｨｰ06 ｨｮ 64,45 ﾀ1,8, ｨｪ0200ｨ ｨｰｨｨ09ｨｪ04ｨｦ ｨC ｨｮ 72,88 ﾀ2,77 ｨ 0605ｨｹｨｪ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0408, ｨ 09ｨｪ06 ｨｨｨｪ0102ｨｺ09ｨｮ DAS28, ｨｰｨ 09ｨｨ05ｨ 5,8 ﾀ1,5 ｨ ｨ ｨ ｨ ｨｪｨｨ02 ｨ 0605ｨｹｨｪ ｨｨ050609ｨｹ ｨｰｨ ｨｪｨｨｨｨ 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ070706ｨｦ, ｨｺ06ｨｰ0608ｨｮ ｨｰｨ 09ｨｨ05ｨｨ 20 07ｨ 02ｨｨ02ｨｪｨｰ ｨ 0605ｨｹｨｪ ｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ ｨｪ0705ｨｨ09ｨｹ 06ｨ ｨｴ02ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ ｨ ｨ ｨｪｨｨ02, 0907ｨｨ0806ｨｬ02ｨｰ08ｨｨ07, ｨｬｨｮ05ｨｹｨｰｨｨ0907ｨｨ08ｨ 05ｨｹｨｪｨ 07 ｨｺ06ｨｬ07ｨｹ06ｨｰ0208ｨｪｨ 07 ｨｰ06ｨｬ060008ｨ 00ｨｨ07 ( ) ｨｺｨｨ ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ 06ｨ 09ｨｮ030102ｨｪｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨｨｨ ｨ 0302ｨｪｨｨ ｨ ｨｪ ｨ ｨｪｨｨ ｨｨ ｨｪｨ ﾂｨ 05ｨｹｨｪ ｨｪｨｨ09ｨ 05ｨｨ09ｨｹ 03ｨ 0506ｨ 04 ｨ 0605ｨｹｨｪ ｨｹｨｪ ｨｲ0709ｨｨ05ｨｨ 03ｨ 0506ｨ 04 ｨｪｨ 08ｨ ｨｪｨｪ0202 ｨｨ ｨｰ0607ｨｪｨｪ ｨｪ0609ｨｰｨｪ ｨ ｨｪｨｨ02, ﾂｨｮ0909ｨｰ ｨｨ09ｨｺ06ｨｬ000608ｨｰｨ ,6% ｨ 0605ｨｹｨｪ ｨｨｨｬ ｨｪｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｺｨ ｨｹ ｨｺｨ 0708ｨｨ 00ｨｨ04ｨｨ- ﾂ0209ｨｺ06ｨｦ ｨｪｨ 0008ｨｮ04ｨｺ02 ｨｨｨｬ0205ｨ 09ｨｹ ｨｮ 13,7% 07ｨ 02ｨｨ02ｨｪｨｰ0609, 09 ｨｰ06ｨｬ ﾂｨｨ ｨｰ ｨ 07 ｨｨ 06 ﾂ02ｨｪｨｹ ｨｰ ｨ 07 ｨC ｨｮ 4%1 7 06ｨｰ ｨｰ0607ｨｪｨｨ ｨｺｨ ｨ 02ｨｰ ｨ 0502ｨｪｨｨ02 ｨｨｨｪｨｰ020809ｨｰｨｨ02ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｰｨｺｨ ｨｪｨｨ ﾂｨｪ06ｨｦ 07ｨ 0802ｨｪ01ｨｨｨｬ ｨｨ08ｨ ｨｰ0608ｨｪ ｨ 0506ｨ 04 ｨｮ ｨ 0605ｨｹｨｪ ｨｰ0802 ﾂｨ 05ｨｨ09ｨｹ 0708ｨｨ ｨｺ06ｨｦ ｨｨ ｨｪ02ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ1 7 02ｨ 06ｨ ｨｴｨ 07 03ｨ 0506ｨ 04 ｨ 0605ｨｹｨｪ0401, ｨｬ0603ｨｪ06 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ ｨｹ ｨ 09ｨｰｨｪ04ｨｬｨｨ ｨｨ0601ｨ ｨｬｨｨ ｨ 09ｨｰｨｪ06ｨｬ ｨ ｨｺｨｰ02 ｨｪｨ ｨｨｨ 0605ｨｹ03ｨ ｨｰ0802 ﾂｨ 02ｨｬ0609ｨｰｨｹ 06ｨｰｨｬ02 ﾂｨ 02ｨｰ ｨ 09ｨｰ02 50ｨC ｨｰ (07ｨ 02ｨｨ02ｨｪｨｰ ｨ ｨｪ ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｯ 0308ｨｨ ｨｪｨｨ02

3 ｨｪ ｨ 09ｨｰｨ ｨC 1/3 06ｨ ｨｴ ﾂｨｨ0905ｨ 06ｨ ｨ ｨｪｨｪ0401)1 7 01ｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨｨｨ 09ｨｪ0203ｨｪ ｨ ｨｪｨｨ07 (080002) ｨｪ04 ｨｮ 47 ｨ 0605ｨｹｨｪ ｨｨ ｨｺｨｨ01 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｰ060806ｨｪ ｨｺｨｨ01, , ｨｪｨｨ03ｨｪｨｨ ｨ ｨｰ0205ｨｹｨｪ ｨｮｨｰ02ｨｦ ｨｨ ｨ ｨｪ ｨｰ02ｨｪｨｨ ｨｪ04 ｨｮ 38 ｨ 0605ｨｹｨｪ ｨｨ ｨｺｨｨ ｨｨ04ｨｪｨ ｨｺｨｨ ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ ｨ ｨｰ0205ｨｹｨｪ ｨｮｨｰ02ｨｦ ｨｪｨ ｨｮ080609ｨｪ ｨｪｨｰ08ｨ 05ｨｹｨｪ0401, , ｨｬ02ｨｪｨｰｨ 08ｨｪ0401 ｨｨ 09ｨｮｨ ｨｬ02ｨｪｨｰｨ 08ｨｪ0401 ｨ 0806ｨｪ ｨｪ04 ｨｮ 34% ｨ 0605ｨｹｨｪ ｨ ｨｨｨ ﾂｨ 09ｨｰ06 06ｨ ｨｪｨ 08ｨｮ03ｨｨ09ｨ 05ｨｨ09ｨｹ ｨｮｨｰ0605ｨｴ02ｨｪｨｨ02 09ｨｰ02ｨｪ06ｨｺ ｨ 0806ｨｪ ｨｨ ｨｬｨ 02ｨｨ07 ｨｨ ｨｰｨ (ｨｮ 25% ｨ 0605ｨｹｨｪ ) ｨｨ04ｨｪｨ ｨｺｨｨ ｨ 0302ｨｪｨｨ07 01ｨｨ09ｨｰｨ 05ｨｹｨｪ ｨｰ ｨ 0806ｨｪ01ｨｨｨ 05ｨｹｨｪ ｨ (ｨ 0806ｨｪ01ｨｨ0605ｨｨｨｰ) ｨｪ04 54% ｨ 0605ｨｹｨｪ ｨ ｨｴｨ 07 08ｨ ｨｰ08ｨ ｨｪ02ｨｪｨｪ0609ｨｰｨｹ ｨ 08ｨｨｨ ｨｪｨｰ ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ ｨ ｨｰ0205ｨｹｨｪ ｨｮｨｰ02ｨｦ ｨｮ 06ｨ ｨ ｨｪｨｪ0401 ｨｪｨ ｨｬｨｨ ｨ 0605ｨｹｨｪ ｨｺｨ 04ｨ 05ｨ 09ｨｹ ｨｪ0206ｨ 04 ﾂｨｪ ｨｺ06ｨｦ ｨｪ0209ｨｮ09ｨｰｨ 09ｨｪ ｨｪｨｨ07 04ｨ ｨ ｨ ｨｪｨｨ ｨ 0302ｨｪｨｨ02 ｨｪｨｨ03ｨｪｨｨ ｨ ｨｰ0205ｨｹｨｪ ｨｮｨｰ02ｨｦ ｨｰ02ｨｺｨ 0506 ｨｬｨ ｨｨｨｬ07ｨｰ06ｨｬｨｪ06 ｨｨ 06ｨ ｨｪｨ 08ｨｮ03ｨｨ09ｨ ｨｹ 05ｨｨ03ｨｹ 0706 ｨｪｨ 05ｨｨ- ﾂｨｨ06 ｨｨ040605ｨｨ080609ｨ ｨｪｨｪ ｨｨ09ｨｰｨ 05ｨｹｨｪ ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨ 0806ｨｪ010609, ｨｬ ｨｬ06ｨｴｨｹ ｨ ｨｪ ｨｮｨ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ ｨ 0302ｨｪｨｨ07, ｨｺｨ ｨｺ 0708ｨ 09ｨｨ0506, ｨｪ ｨｨ090502ｨｺｨ 06ｨｰ 09ｨｪｨｨｨｬｨ ｨｪｨｨ ｨ ﾂ02ｨｦ ｨｨ 09ｨ ｨｬｨｨ01 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨｨ 09 ｨｺ08ｨ ｨｰｨｺ ﾂｨｪ06ｨｬ ｨ ｨｺｨｰ02 ｨｪ02 ｨｰ0802ｨ ｨｮ06ｨｰ ｨｨｨ 05ｨｹｨｪ ﾂ02ｨｪｨｨ ｨ ｨｰ0205ｨｹｨｪ06, 08ｨ ｨｪｨｪ ｨｪｨｨ02 ｨｮ ｨ 0605ｨｹｨｪ ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ ｨ ｨｰ0205ｨｹｨｪ ｨｮｨｰ02ｨｦ ｨｨ ｨｬ06ｨｪｨｨｨｰ0608ｨｨ080609ｨ ｨｪｨｨ02 ｨｮ ｨｪｨｨ01 01ｨｨｨｪｨ ｨｬｨｨｨｺｨｨ ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ01 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ0401 ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨｮ02ｨｰ 09 ﾂｨｨｨｰｨ ｨｰｨｹ ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺｨｨ 09ｨ 03ｨｪ04ｨｬ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ06ｨｬ ﾂｨｪ06ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ 0706ｨｬ06ｨｴｨｨ 0708ｨｨ 01ｨ ｨｪｨｪ06ｨｬ 04ｨ ｨ ｨ ｨｪｨｨｨｨ1 7 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 08ｨ ｨｰ08ｨ ｨｪ02ｨｪｨｪ0609ｨｰｨｹ ｨｨ ｨｺ05ｨｨｨｪｨｨ- ﾂ0209ｨｺｨ 07 04ｨｪｨ ﾂｨｨｨｬ0609ｨｰｨｹ ｨ 0302ｨｪｨｨｨｦ ｨ ｨｪ ｨ ｨｪｨｨ ｨｨ ｨｹｨｬｨ ｨｨｨｺｨｨ ｨｨ 08ｨ ｨｪ ﾂ0209ｨｨ01ｨｪ06 ｨｪ ｨｪｨｨ09ｨ 05ｨｨ09ｨｹ ｨｨ04ｨｪｨ ｨｺｨｨ ﾂ02ｨｪｨｨ ｨｺｨｨ01, ｨｨ ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ ｨ ｨｰ0205ｨｹｨｪ ｨｮｨｰ02ｨｦ ｨｰ ｨ 04ｨｪ ﾂ02ｨｰｨ ｨｪｨｨ0701 ｨｮ 37,6% 07ｨ 02ｨｨ02ｨｪｨｰ ｨ 0605ｨｹｨｪ ｨｰ0802 ﾂｨ 06ｨｰ ｨ 0302ｨｪｨｨ ｨｰ ｨｨ08ｨ ｨｰ0608ｨｪ ｨｰ08ｨ ｨｺｨｰｨ ｨC ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ0401 ｨｨ 01ｨｨ09ｨｰｨ 05ｨｹｨｪ0401 ｨ 0806ｨｪ010609, ｨｨｨｪｨｰ020809ｨｰｨｨ02ｨｨ07 ｨｨ 07ｨ 0802ｨｪ01ｨｨｨｬ ｨｺｨｨ01, ｨ ｨｰｨ ｨｺ ｨ 02ｨｪｨｪ0609ｨｰｨｹ06 ｨｰ02 ﾂ02ｨｪｨｨ07 ｨ 0806ｨｪ ﾂｨｪ ｨ 0302ｨｪｨｨｨｦ ｨｮ ｨ 0605ｨｹｨｪ ｨｰ0907 ｨｨ01 ｨｬｨｪ060006ｨｮ080609ｨｪ020904ｨｦ 01ｨ 08ｨ ｨｺｨｰ0208, ｨｴｨｨｨｦ ｨ 00ｨ ｨｰｨｹ ｨ ｨｪｨ ｨｰ06ｨｬｨｨ ﾂ0209ｨｺｨｮ06 ｨｪ ｨｪ0609ｨｰｨｹ ｨ 05ｨｨｨｰ0205ｨｹｨｪ0609ｨｺ ｨｰｨｨ ﾂ0209ｨｺ ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ ｨ ｨｰ0205ｨｹｨｪ ｨｮｨｰ02ｨｦ ｨｬｨｪ0600ｨｨ01 ｨ 0605ｨｹｨｪ ｨ 0302ｨｪｨｨ ｨｺｨｨ01 ｨｨ ｨｪｨｨ03ｨｪｨｨ ｨ ｨｰ0205ｨｹｨｪ ｨｮｨｰ02ｨｦ, ｨｨｨｬ0206ｨｴｨｨ02 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺ ｨｪｨ ﾂ02ｨｪｨｨ02, ｨｰ02ｨｺｨ 06ｨｰ 09ｨｮｨ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ, ﾂｨｰ06 ｨｰ0802ｨ ｨｮ02ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0401 ｨｬ ｨｨ07ｨｰｨｨｨｦ 0706 ｨｨ ｨｪｨｨ ｨ ｨｨｨ 0605ｨｹ ｨｪｨ ﾂ02ｨｪｨｨ ｨｪｨｨ07 ｨｨ ｨｮｨｰ06 ﾂｨｪ02ｨｪｨｨ07 01ｨ 08ｨ ｨｺｨｰ0208ｨ ｨ 0302ｨｪｨｨｨｦ ｨ ｨｪ ｨ ｨｪｨｨ07 ｨｮ ｨ 0605ｨｹｨｪ ｨｨｨｬ0202ｨｰ 0906 ﾂ02ｨｰｨ ｨｪｨｪ ｨｨｨｬ02ｨｪ02ｨｪｨｨ ｨｺｨｨ01 ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｨ ｨ ｨｪｨｨｨｦ1 7 02ｨ ｨｴ020708ｨｨｨｪ07ｨｰ ｨｺ 0502 ﾂ02ｨｪｨｨ06 ｨ 0806ｨｪ ﾂｨｪ ｨ 0302ｨｪｨｨｨｦ ｨｮ ｨ 0605ｨｹｨｪ ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ02ｨｪｨｨ ｨｪ ｨｬｨｨ080609ｨ ｨｪ ｨｨ ｨｪ02ｨｨｨｪ0002ｨｺ02ｨｨ06ｨｪｨｪ ｨ 0302ｨｪｨｨ ｨｨ09ｨｰｨ 05ｨｹｨｪ0401 ｨ 0806ｨｪ ｨｰ08ｨ 01ｨｨ02ｨｨ06ｨｪｨｪ ｨｨｨ 0200ｨ 06ｨｰ ｨｺ ｨｨｨｬｨｬｨｮｨｪ0609ｨｮ ｨｨ09ｨｪ06ｨｦ ｨｨ 09ｨｨｨｬ07ｨｰ06ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ ｨｪｨ ｨ ｨ 0903ｨｨ ｨｪｨ ｨｬｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609, 0708ｨｨ 0706ｨｰ0802ｨ ｨｪ0609ｨｰｨｨ ﾂ02ｨｪｨｨｨｨ, 0708ｨｨｨｬ02ｨｪ0705ｨｨ09ｨｹ ｨｨｨｪ00ｨ ｨｨ06ｨｪｨｪ0402 ｨ 0806ｨｪ010605ｨｨｨｰｨｨｨｺｨｨ (ｨ 02ｨｰｨ 2-ｨ 0006ｨｪｨｨ09ｨｰ04 ｨｨ ｨｨｨｪ0605ｨｨｨｰｨｨｨｺｨｨ) ｨｪｨ 0006ｨｪ02 ｨ ｨ 04ｨｨ09ｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ ｨｨ ｨ 0806ｨｪ01ｨｨ0605ｨｨｨｰ02 ｨｰ ｨｨ08ｨｮ06ｨｴ ｨｰ02 ﾂ02ｨｪｨｨ ｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨｺｨｰ (09ｨｰｨ ｨ ｨｨ05ｨｨ04ｨ 02ｨｨ ｨｺｨ 04ｨ ｨｰ020502ｨｦ , 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0602 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ ｨ 0302ｨｪｨｪ0609ｨｰｨｨ ｨｺｨ ｨｨ ｨｺｨｨ) ｨｮ ﾂ02ｨｪ ｨｪｨ ｨｬｨｨ ｨｪｨ 0006ｨｪ02 ｨｺ06ｨｬｨ ｨｨｨｪｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨｨｨｬｨｬｨｮｨｪ0609ｨｮ ｨｨ09ｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ ｨｬ02: ｨ 04ｨ ｨｰｨｨ060708ｨｨｨｪ 100ｨｬ00/09ｨｮｨｰ ｨｪｨｨ ｨｪ 10ｨｬ00/09ｨｮｨｰ, ｨ ｨｰｨ ｨｺ0302 ｨｨｨｪ00ｨ ｨｨ06ｨｪｨｪ ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 ｨ 0806ｨｪ010605ｨｨｨｰｨｨｨｺ ﾂ02ｨｪｨｨ02 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ ｨｬ ｨｨ ｨｨｨｪｨｰ020809ｨｰｨｨ02ｨｨｨ 05ｨｹｨｪ06ｨｬ 07ｨｪ0209ｨｬ06ｨｪｨｨｨｰ ｨｺ06ｨｬ02ｨｪ01ｨｮ02ｨｰ0907 ｨｪｨ ﾂｨｨｨｪｨ ｨｰｨｹ ｨｨ02ｨｬｨ ｨｺ0608ｨｰｨｨｨｺ0609ｨｰ020806ｨｨ ｨｪｨｮｨｰ08ｨｹ ( ｨｪｨｨ ｨｪ 0,5ｨｬ00/ｨｺ00/09ｨｮｨｰ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 1ｨC3 ｨｬ ) ｨｨ ｨｮ05ｨｮ ﾂ0302ｨｪｨｨｨｨ, ｨｰ ｨ 02ｨｬ06ｨｬ ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 01ｨｨｨｪｨ ｨｬｨｨｨｺ06ｨｦ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｨ 0802ｨｪｨｰ0002ｨｪ ｨｨ ﾂ0209ｨｺｨｨ ｨｺｨ 04ｨ ｨｰ020502ｨｦ, ｨ ｨｪｨｨ ｨｪｨ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 09ｨｪｨｨ0302ｨｪｨ ｨｬ00/09ｨｮｨｰ ｨｨ05ｨｨ 20ｨｬ00/09ｨｮｨｰ ﾂ ｨｪｨｹ ｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 01ｨｨｨｪｨ ｨｬｨｨｨｺｨｨ ｨｰ0607ｨｪｨｨｨｨ ｨ 0605ｨｹｨｪ ｨｪｨ 0006ｨｪ02 ｨｮｨｬ020802ｨｪｨｪ ｨ 05ｨｹｨｪ ｨｰ020806ｨｨ010609, ｨ 08ｨ 04ｨｪ ｨｪｨｨｨｰｨｹ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ01 ｨｺ06ｨｬｨ ｨｨｨｪｨ 02ｨｨｨｨ 09 ｨｨｨｬｨｬｨｮｨｪ ｨ ｨｪｨｰｨ ｨｬｨｨ ｨ ｨｪ ｨｮ ﾂｨ ｨｨ 0502 ﾂ02ｨｪｨｨｨｨ ｨｨ01ｨｨ0607ｨ ｨｰｨｨ ﾂ0209ｨｺ ﾂｨｪ ｨｨｨ ｨ ｨｨ ｨｹ04ｨｮ02ｨｰ ﾂ02ｨｰｨ ｨｪｨｨ ｨｪｨｨ ｨｪｨ (0,5ｨｬ00/ｨｺ00/09ｨｮｨｰ ｨｪｨｨ0302ｨｪｨｨ02ｨｬ 04ｨ 3 ｨｬ ｨ ,125ｨｬ00/ｨｺ00/09ｨｮｨｰ) ｨｨ ｨ 04ｨ ｨｰｨｨ060708ｨｨｨｪｨ (2ｨC3ｨｬ00/ｨｺ00/09ｨｮｨｰ, ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪｨ ｨ 150ｨｬ00/09ｨｮｨｰ)1 7 01ｨ 04ｨｪｨ ﾂ02ｨｪｨｨ ｨｺｨｨ ｨｰ020806ｨｨ ｨｨ0102 ｨｬ06ｨｪ06ｨｰ0208ｨ 07ｨｨｨｨ ｨｪ ｨｺ06ｨｬ02ｨｪ01ｨｮ02ｨｰ0907, ｨ 02ｨｪｨｪ06 ｨｮ ｨ 0605ｨｹｨｪ ｨ 0302ｨｪｨｪ04ｨｬ 00ｨｨｨ ｨｬ (00ｨｨ09ｨｰ ｨｨ ﾂ0209ｨｺｨｨ ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪｨ 07 06ｨ 04 ﾂｨｪｨ 07 ｨｨｨｪｨｰ020809ｨｰｨｨ02ｨｨｨ 05ｨｹｨｪｨ 07 07ｨｪ0209ｨｬ06ｨｪｨｨ07 ｨｨ05ｨｨ 0709ｨｪｨ ｨｰ0609ｨ 0703 ｨｰ08ｨ ｨｪ ｨｬｨ 02ｨｨ ﾂｨｪ06ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨ ｨｪｨｪ04ｨｬ )1 7 00ｨ 03ｨｪｨｮ ｨｹ ｨｪｨｨｨｨ ｨ 0605ｨｹｨｪ ｨｨｨｪｨｰ020809ｨｰｨｨ02ｨｨｨ 05ｨｹｨｪ04ｨｬ ｨ 0302ｨｪｨｨ02ｨｬ ｨｺｨｨ ｨｪ04 ｨｨ0008ｨ ｨｰｨｹ 0607ｨｰｨｨｨｬｨ 05ｨｹｨｪｨ ｨｨ09ｨ 06ｨｴｨ 07 ｨｰ0208ｨ 07ｨｨ07, 09ｨｺ0506 ﾂｨ 06ｨｴｨ ﾂｨｪｨｮ06 ｨｺｨｨ ｨｰ0208ｨ 07ｨｨ06, ｨｨ ﾂｨｪｨ ｨ ｨ ｨｨ05ｨｨｨｰｨ 02ｨｨ ｨ 02ｨｨ02ｨｪｨｰ ｨｪ02ｨｮｨｺ0506ｨｪｨｪ ｨｨ08ｨｮ06ｨｴｨｨｨｬ ｨｰ02 ﾂ02ｨｪｨｨ02ｨｬ ｨｨ ｨｨｨｪｨｰ020809ｨｰｨｨ02ｨｨｨ 05ｨｹｨｪ06ｨｬ 07ｨｪ0209ｨｬ06ｨｪｨｨｨｰ ｨｨｨｪ09ｨｰ0902ｨｪｨｪ06ｨｦ ｨｬ0603ｨｪ0609ｨｰｨｹ ｨｪｨｨ07 03ｨｨ04ｨｪｨｨ ｨｨ ｨｪｨｨ ｨｺｨ ﾂ0209ｨｰ09ｨ ｨｬ060302ｨｰ 06ｨｺｨ 04ｨ ｨｰｨｹ0907 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ ｨｺｨｨ : ｨ 02ｨｨ02ｨｪｨｰ ｨ 0806ｨｪ ﾂｨｪ04ｨｬ ｨ 0302ｨｪｨｨ02ｨｬ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨｨｨ 09ｨｪ0203ｨｪ ｨ ｨｪｨｨ ｨｨｨｬｨｮｨｴ0209ｨｰ0902ｨｪｨｪ ｨｬ0203ｨ ｨｪｨｪ06ｨｬｨｮ ｨｰｨｨ07ｨｮ ﾂｨｨｨｰ0409ｨ 07 01ｨ 08ｨ ｨｺｨｰ0208 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ( ｨ 05ｨ 01ｨ 06ｨｴ ｨｪｨｨ0302ｨｪｨｨ ｨｨ 08ｨ 09 ﾂ02ｨｰ02 ｨｨｨｪ0102ｨｺ09ｨ 06ｨｨ0000ｨｪ06), ｨｬ0603ｨｪ ｨｨｨｰｨｹ, ﾂｨｰ ｨｨ ｨ 0806ｨｪ ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｯ 0308ｨｨ ｨｪｨｨ02 3

4 ﾂｨｪ ｨ 0302ｨｪｨｨ ｨｮ06 06 ﾂ ｨｹ ｨｺｨ 06ｨｰ ｨｬ0205ｨｺｨｨ02 ｨ 0806ｨｪ01ｨｨ ｨ 0302ｨｪｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨｨｨ 09ｨｪ0203ｨｪ ｨ ｨｪｨｨ07 ｨ ｨ 08ｨ ｨｺｨｰ0208ｨｪ ｨｨｨ ｨｪ06ｨｦ 09ｨｰｨ 01ｨｨｨｨ 04ｨ ｨ ｨ ｨｪｨｨ ｨ 05ｨ 01ｨ 06ｨｴｨｨ02 ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｨｨｬ0206ｨｰ ｨｰ02ｨｪ0102ｨｪ02ｨｨ06 ｨｺ ｨｪ0608ｨｬｨ 05ｨｨ04ｨ 02ｨｨｨｨ 0706 ｨｬ ｨｨ ﾂ02ｨｪｨｨ07 07ｨｪ0209ｨｬ06ｨｪｨｨｨｰｨ ｨｪｨｨ02 ｨｬｨｮ05ｨｹｨｰｨｨ0907ｨｨ08ｨ 05ｨｹｨｪ06ｨｦ ｨｺ06ｨｬ07ｨｹ06ｨｰ0208ｨｪ06ｨｦ ｨｰ06ｨｬ060008ｨ 00ｨｨｨｨ ｨｺｨｨ01 ｨｮ ｨ 0605ｨｹｨｪ ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｬ ｨ 08ｨｰ08ｨｨｨｰ06ｨｬ ｨｰ ｨｨｨｰｨｹ ｨｬ02ｨｪｨｪｨｮ06 01ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨｮ ｨｨ ｨｬ02ｨｪｨｪ06 09ｨｪ0609ｨｨｨｰｨｹ ｨｺ ｨｺｨｰｨｨ ﾂ02ｨｪｨｨ02, ﾂｨｰ06 ｨｮ05ｨｮ ﾂ03ｨ 02ｨｰ ｨｪ ｨ ｨ ｨ ｨｪｨｨ ｨ 0906ｨｪ ｨｬｨ ｨｰ ｨｨ ｨ 02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｮｨｺ ｨｰ : ｨｰｨ ｨｨｨ ; ｨ 0906ｨｪ ｨ 08ｨｬｨ ｨｺ06ｨｰ0208ｨ 07ｨｨ ｨｬｨ ｨｰ06ｨｨ01ｨｪ ｨ 08ｨｰ08ｨｨｨｰｨ ｨｮ 0002ｨｪｨｪ06-ｨｨｨｪ0302ｨｪ0208ｨｪ0401 ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨ 08ｨ ｨｰ0609 // ｨ ｨC ｨC ｨ ｨ ｨｦ01ｨｮ0505ｨ ｨｰ06 07ｨｨｨｺ000506ｨｮｨｬ02ｨｰ08ｨｨｨｨ 09 ｨｺ06ｨｬ070502ｨｺ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｨ ｨ ｨｪｨｨｨｦ 09 07ｨｮ05ｨｹｨｬ06ｨｪ ｨｨｨｨ: 0002ｨｰ ｨｺ06ｨｬ ｨ ﾂ02ｨｦ1 7 ｨC ｨC ｨｬ02ｨｪｨｺ ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ: ｨｬ02ｨｪｨｪ ｨｰ0607ｨｪｨｨ ｨ 0502ｨｬ ｨｹ ｨｺ08ｨ ｨｨｨｪ09ｨｺｨ 07 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨ 07 00ｨ 0402ｨｰｨ ; 22: Furst D1 7E1 7, Keystone E1 7C1 7, Kirkham B1 7, Kavanaugh A1 7 [et al1 7] Updated consensus statement on biological agents for the treatment of rheumatic diseases, Ann Rheum Dis ;67 (Suppl 3):2ｨC Greenwald M1 7, Peloso P1 7, Hasler F1 7 [et al1 7] Etoricoxib improves pain and function in rheumatoid arthritis patients on background biologic therapy1 7 A&R, 2015, 60 (10), suppl1 7, , ｨｬ020209ｨ , 06ｨｮ05ｨｹｨｪ [ｨｨ ] ｨｮ05ｨｹｨｰｨ ｨｰ ｨｪ06ｨｬ06ｨｬ02ｨｪｨｰｨｪ ｨｨ0102ｨｬｨｨ ｨｨ ﾂ0209ｨｺ ｨｨ ｨ ｨｪｨｨ ｨｪｨｨ ｨｰ0802ｨ ｨｪ0609ｨｰｨｨ ｨｪｨｪ06-ｨｨｨｪ0302ｨｪ0208ｨｪ0401 ｨ ｨｨ ｨｨ ﾂ0209ｨｺｨｨ ｨ 08ｨ ｨｰｨ ｨｰ0208ｨ 07ｨｨｨｨ ｨ 0605ｨｹｨｪ ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｬ ｨ 08ｨｰ08ｨｨｨｰ06ｨｬ ｨ 05ｨｹｨｪ06ｨｦ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺ ｨ ｨｮ ﾂ-0708ｨ ｨｺｨｰｨｨ ﾂ ｨｬｨ ｨｰ ｨｨ ;4:4ｨC Rizamukhamedova 001 7Z1 7, Mukhammadieva S , Abduazizova N Features of course and condition of cardio respiratory systems in rheumatoid arthritis and systemic lupus erythematosus // European journal of natural history Greenwald M1 7, Peloso P1 7, Hasler F1 7 [et al1 7] Etoricoxib improves pain and function in rheumatoid arthritis patients on background biologic therapy1 7 A&R, 2011, 60 (10), suppl1 7, Krishan E1 7, Lingela B1 7, Bruce B1 7, Fries J1 7 Disability in rheumatoid arthritis in the era of biological treatments1 7 Ann Rheum Dis 2012;71:213ｨC81 7 EXTERNAL RESPIRATION FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS Abduazizova N1 7H1 7 Tashkent Medical Academy, Tashkent, Republic of Uzbekistan Among the extra-articular manifestations of rheumatoid arthritis, pulmonary involvement has an important function1 7 The study of clinical and functional pulmonary disorders, performing multislice computed tomography and monitoring study of bronchial patency in patients with pulmonary rheumatoid arthritis allow timely adjustments in treatment1 7 Keywords: rheumatoid arthritis, diagnosis, multislice computed tomography, spirometry ﾁ ｨ 01ｨｮ0505ｨ 0209, ｨ ｨｬｨ ｨｪｨ 04ｨ ｨ, ｨｺｨ ｨｪ ｨ, ｨ ｨｺ09ｨｮ010609ｨ ｨｺｨ 07 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨ 07 ｨ 0605ｨｹｨｪｨｨ02ｨ 017, ｨ 03ｨｺ02ｨｪｨｰ, ｨｮｨ 05ｨｨｨｺｨ 0704ｨ 02ｨｺｨｨ09ｨｰｨ ｨｪ 06ｨ 03ｨｺ02ｨｪｨｰ09ｨｺｨｨｨｦ ｨｨｨ ｨｰ08ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨｨｦ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ, ｨ 03ｨｺ02ｨｪｨｰ, ｨｮｨ 05ｨｨｨｺｨ 0704ｨ 02ｨｺｨｨ09ｨｰｨ ｨｪ 00 09ｨｰｨ ｨｰｨｹ ｨｰｨ ｨｪ ｨｮ05ｨｹｨｰｨ ｨｰ04 06ｨ ｨ ｨｪｨｨ ｨ 02ｨｨ02ｨｪｨｰ ｨｰ0206ｨ 08ｨｰ ｨｬ 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ ｨｨｨｪ0102ｨｺ09ｨ ｨｬｨ ｨｰ0205ｨ ｨ 0605ｨｹｨｪ ｨｰ0206ｨ 08ｨｰ ｨｬ ｨｨ0802ｨｪｨｨ02ｨｬ (060006>30) ｨｪ06 ｨ ｨｰ ｨｰ02 ﾂ02ｨｪｨｨ ｨｰ0206ｨ 08ｨｰ080604ｨ ｨｪｨｪ04ｨｬｨｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07ｨｬｨｨ , ｨｨｨｪ0102ｨｺ Lequesne ｨｨ WOMAC, ﾂｨｰ ｨ ｨｹ ｨ 0605ｨｹ03ｨｨｨｬ ｨ ｨｪｨｨ02ｨｬ 09 ｨｺ080609ｨｨ ｨｨ ﾂ ｨ : 0609ｨｰ0206ｨ 08ｨｰ080604, 0603ｨｨ0802ｨｪｨｨ02, ｨｨｨｪｨｰ ｨｦｨｺｨｨｨｪ-6, ｨ ｨｺｨｰｨｨ09ｨｪ04ｨｦ ｨ ｨｺ ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｯ 0308ｨｨ ｨｪｨｨ02

5 000205ｨｹ ｨｨ ｨ ｨｪｨｨ07 ｨC ｨｨｨｰｨｹ ｨｺ05ｨｨｨｪｨｨｨｺ06-ｨｨｨｬｨｬｨｮｨｪ ｨｨ ﾂ0209ｨｺｨｨ02 07ｨ 08ｨ ｨｬ02ｨｰ0804 ｨｮ ｨ 0605ｨｹｨｪ ｨｰ0206ｨ 08ｨｰ ｨｬ (0208) 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ 0603ｨｨ0802ｨｪｨｨ ｨ ｨｰ0208ｨｨｨ 05 ｨｨ ｨｬ02ｨｰ ｨ ｨ ｨｪ ｨ 02ｨｨ02ｨｪｨｰｨ , ｨｬｨｮ03 ﾂｨｨｨｪ 28 (39,8%), 0302ｨｪｨｴｨｨｨｪ 44 (61,1%), ｨｪｨｨｨｦ ｨ 09ｨｰ 52,3 ﾀ8, ｨ, 0105ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨ ｨｪｨｨ 11,2 ﾀ4,3 0502ｨｰ1 7 02ｨｨｨ 00ｨｪ ｨｨ00ｨｨ02ｨｨ080609ｨ 05ｨｨ ｨ 09ｨｪ06 ｨｺ08ｨｨｨｰ0208ｨｨ07ｨｬ ACR1 7 08ｨｪｨｰ ｨｬ02ｨｰ08ｨｨ ﾂ0209ｨｺｨｨ02 01ｨ ｨｪｨｪ0402 (000205, 1977) ｨｪｨｨ09ｨ 05ｨｨ ｨｰｨｮ, ｨｬｨ ｨｰ0205ｨ, 06ｨｺ08ｨｮ03ｨｪ0609ｨｰｨｨ ｨｰｨ 05ｨｨｨｨ ｨｨ ｨ , ｨｨｨｪ0102ｨｺ09ｨｮ ｨｬｨ ｨｰ0205ｨ (060006; ｨｬｨ 0909ｨ ｨｰ0205ｨ (ｨｺ00) / ｨｰ (ｨｬ 2 ) ｨｨｨｪｨｨｨｺ06-ｨｨｨｪ09ｨｰ08ｨｮｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0402 ｨｨ ｨ ｨｪｨｨ ｨｨ05ｨｨ ｨｬ06ｨｪ06ｨ 08ｨｰ ｨｮ 2 (2,8%), 0605ｨｨ0006ｨ 08ｨｰ ｨC ｨｮ 32 (44,4%), ｨｨ0609ｨｰ0206ｨ 08ｨｰ ｨC ｨｮ 38 (52,8%) 07ｨ 02ｨｨ02ｨｪｨｰ ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺｨｨ ｨ 0605ｨｨ ｨｹ040609ｨ 05ｨｨ09ｨｹ 10-09ｨ ｨｪｨｰｨｨｨｬ02ｨｰ ｨｦ 09ｨｨ04ｨｮｨ 05ｨｹｨｪ06-ｨ ｨｪｨ ｨｦ 03ｨｺｨ 0506ｨｦ (000801), 0708ｨｨ 0208 ｨｺ060502ｨｪｨｪ0401 ｨｨ ｨｰｨ 0406ｨ ｨｪｨｪ ｨｮ09ｨｰｨ ｨｨ ｨｨｨｪ0102ｨｺ0904 Lequesne ｨｨ WOMAC1 7 02ｨｨｨ 00ｨｪ ｨｺ0909ｨｮ01ｨ ｨｰｨｨ09ｨｪ ｨｨｨｪ0609ｨｨｨｰｨ ｨｮ09ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ 05ｨｨ 0706 ｨｪｨ 05ｨｨ ﾂｨｨ06 03ｨｨ01ｨｺ0609ｨｰｨｨ ｨｰｨｨ 09ｨｮ09ｨｰｨ 09ｨ, ｨｨ000208ｨ ｨｰｨｨ09ｨｪ ｨC 0706 ｨｮｨｰ0605ｨｴ02ｨｪｨｨ06 09ｨｨｨｪ0609ｨｨｨ 05ｨｹｨｪ06ｨｦ 06ｨ ﾂｨｺｨｨ ｨｨ ｨ ｨｬｨｬ ｨ 0605ｨｹｨｪ ｨｪ ｨ ｨｪｨｨ ｨ 05ｨｨｨｰ0205ｨｹｨｪ0401 ｨｬｨ 08ｨｺ ｨｨ 02ｨｨｨｰ06ｨｺｨｨｨｪｨ ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ ｨ 0605ｨｹｨｪ ｨ ｨｪ04 ｨｪｨ ｨｮ070704: <30, n=22 (06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ ｨｨ0802ｨｪｨｨ07); >30, ｨｨ04ｨｪｨ ｨｺｨ ｨｬｨｨ 0603ｨｨ0802ｨｪｨｨ07 I-II-III 09ｨｰ020702ｨｪｨｨ, n= ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ 06ｨ 09ｨｮ030102ｨｪｨｨ ｨ 0605ｨｹｨｪ ｨｨ0802ｨｪｨｨ02ｨｬ 06ｨｰｨｬ02 ﾂｨ 05ｨｨ09ｨｹ ｨ ｨｺｨｨ02 04ｨｪｨ ﾂ02ｨｪｨｨ ｨｨ 0109ｨｨ0302ｨｪｨｨｨｨ ｨｨ ｨｨｨｪ0102ｨｺ09ｨ Lequesne, ﾂ02ｨｬ ｨｮ ｨ 0605ｨｹｨｪ ｨｪ0608ｨｬｨ 05ｨｹｨｪ06ｨｦ ｨｬｨ ｨｦ ｨｰ0205ｨ (5,8 ﾀ1,2 09ｨｬ ｨｨ 5,8 ﾀ1,1 ｨ ｨ ｨｰｨｨ09 1,8 ﾀ0,4 09ｨｬ ｨｨ 2,3 ﾀ0,5 ｨ ｨ ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06, p<0,05)1 7 03ｨ 08ｨ ｨｬ02ｨｰ0804 WOMAC ｨ 0302ｨｪｨｪ0609ｨｰｨｨ ｨ 0605ｨｨ, ｨｮｨｰ0802ｨｪｨｪ02ｨｦ 09ｨｺ0609ｨ ｨｪｨｪ0609ｨｰｨｨ ｨｨ ｨｨｨｪ0102ｨｺ09ｨｮ WOMAC ｨｰｨ ｨｺ0302 ｨ 0405ｨｨ ｨｰ ｨｪ ｨｮ ｨ 0605ｨｹｨｪ ｨｨ04ｨ 04ｨｰ06 ﾂｨｪ06ｨｦ ｨｬｨ ｨｦ ｨｰ0205ｨ, ﾂ02ｨｬ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨ ｨｨ0802ｨｪｨｨ07 (46,9 ﾀ5,9; 16,8 ﾀ4,6; 252,8 ﾀ50, ｨｰｨｨ09 27,8 ﾀ3,6; 9,7 ﾀ2,7; 210,7 ﾀ45, ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06, P<0, ｨｨ ｨｪｨｪ04ｨｬ 07ｨ 08ｨ ｨｬ02ｨｰ08ｨ ｨｬ) ｨｮ ｨ 0302ｨｪｨｪ0609ｨｰｨｹ ｨｨ ｨｪｨｨ02ｨｬ ｨｰｨｬ02 ﾂｨ 05ｨ 09ｨｹ ｨｬｨ 07 ｨｺ ｨｨ06ｨｪｨｪｨ ｨｹ (r=0,5, p<0,05) ｨ 0605ｨｹｨｪ ｨｨ0802ｨｪｨｨ02ｨｬ ｨｪ ｨ ｨｺｨｨｨｦ ｨｮ ｨｪｨｹ 0609ｨｰ080600ｨ ｨ 0205ｨｺ0609, ﾂ02ｨｬ 0708ｨｨ ｨｪ0608ｨｬｨ 05ｨｹｨｪ06ｨｦ ｨｬｨ ｨｰ0205ｨ : ｨC 12,6 ﾀ2,1 ｨｬ00/05 ｨｨ 6,2 ﾀ0,7 ｨｬ00/ ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06, P<0,05; ｨC 7,8 ﾀ0,8 ｨｪ00/ ｨｬ05 ｨｨ 4,3 ﾀ0,6 ｨｪ00/ｨｬ ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06, P<0, ｨｰ ｨｨ0102ｨｰ0205ｨｹ09ｨｰ090609ｨ ｨｨ07ｨｪｨｨｨｨ ｨｨ04ｨ 04ｨｰ06 ﾂｨｪ06ｨｦ 03ｨｨ ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨｪｨ 08ｨ 0409ｨｨｨｰｨｨ ｨｪｨｨ ﾂ0209ｨｺ ｨｪ0208ｨ ｨｰｨｨ09ｨｪ ｨｰ08ｨｮｨｺｨｰｨｨ09ｨｪ ｨ 0502ｨｪｨｨ ｨｮ09ｨｰｨ 09ｨ ｨｨ 04ｨ ｨｺ0506 ﾂ02ｨｪｨｨ ｨ 0605ｨｹｨｪ ｨｨ0802ｨｪｨｨ02ｨｬ (060006>30) ｨｪ06 ｨ ｨｰ ｨｰ02 ﾂ02ｨｪｨｨ ｨｰ0206ｨ 08ｨｰ080604ｨ ｨｪｨｪ04ｨｬｨｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07ｨｬｨｨ , ｨｨｨｪ0102ｨｺ Lequesne ｨｨ WOMAC, ﾂｨｰ ｨ ｨｹ ｨ 0605ｨｹ03ｨｨｨｬ ｨ ｨｪｨｨ02ｨｬ 09 ｨｺ080609ｨｨ ｨｨ CLINICAL AND IMMUNOLOGICAL CORRELATIONS IN PATIENTS WITH OSTEOARTHRITIS AND OBESITY Abdullaev A1 7H1 7, Mamanazarova D1 7K1 7, Iskanderova S1 7Dzh1 7, Maksudova M1 7B1 7 City Clinical Hospital No1 77, Tashkent, Republic of Uzbekistan Tashkent Pediatric Medical Institute, Tashkent, Republic of Uzbekistan The article presents the results of a survey of 72 patients with osteoarthritis, depending on the body mass index1 7 Patients with osteoarthritis with obesity (BMI>30) showed more severe osteoarthritis with higher values of VAS, Lequesne index and WOMAC, which was accompanied by high CRP and IL-6 content in blood1 7 Keywords: osteoarthritis, obesity, interleukin-6, C-reactive protein ﾁ DAS ｨ ｨｨ030209ｨ, ｨｨｨｺ0609ｨ, ｨ 08ｨ ｨ 05ｨｨｨｪ0609ｨ, ｨｨｨ 02ｨｺ0609ｨ, ｨ 0209ｨ ｨｨ02ｨｨｨｪ09ｨｺｨｨｨｦ ｨｮｨｪｨｨ ｨｨｨｰ02ｨｰ 0809ｨｰｨ ｨｪｨ 03, ｨｰｨ ｨｪｨ, ｨｮｨ 05ｨｨｨｺｨ 08ｨ 04ｨ 0109ｨｰｨ ｨｪ 00 09ｨｰｨ ｨｰｨｹ ｨｰｨ ｨｪ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｪｨｺｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｰ0208ｨ 07ｨｨｨｨ ｨｬｨ ｨｰ06ｨｨ01ｨｪ ｨ 08ｨｰ08ｨｨｨｰｨ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰ06ｨｬ ｨｨｨｬ02ｨｪ02ｨｪｨｨ02ｨｬ ｨｨｨｪ0102ｨｺ09ｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ ｨ ｨｪｨｨ07 DAS ｨｪｨｪ0602 ｨｨ ｨ ｨｪｨｨ ｨｺｨ 04ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0502 ﾂ02ｨｪｨｨ07 07ｨ 02ｨｨ02ｨｪｨｰ ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｬ ｨ 08ｨｰ08ｨｨｨｰ06ｨｬ ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ06ｨｬｨｮ 09ｨｪｨｨ0302ｨｪｨｨ ｨｨｨｪｨ ｨｬｨｨｨｺ02 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ ｨ ｨｪｨｨ ｨ 09ｨｪ06 ｨｨｨｪ0102ｨｺ09ｨｮ DAS ﾂ ｨ : ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ, ｨｨｨｪ0102ｨｺ09 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ ｨ ｨｪｨｨ07 DAS28, ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰ ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｯ 0308ｨｨ ｨｪｨｨ02 5

6 040209ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ (0408) ｨC 0601ｨｪ06 ｨｨ04 ｨｪｨ ｨｨｨ ｨ ｨｰ08ｨ ｨｪ02ｨｪｨｪ ｨｪｨｨ ﾂ0209ｨｺｨｨ ｨ 05ｨｨｨｰ0205ｨｹｨｪ ｨ ｨ ｨ ｨｪｨｨｨｦ 09ｨｮ09ｨｰｨ ｨｪ02ｨｨ ｨｰｨｪ06ｨｦ 05ｨｰｨｨ ｨｨｨｨ, 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ06ｨｴ ｨｨｨｬｨｬ02ｨｰ08ｨｨ ﾂｨｪ04ｨｬ ｨｪｨｨ ﾂ0209ｨｺｨｨｨｬ ｨｨ09ｨｪ04ｨｬ ｨ 08ｨｰ08ｨｨｨｰ06ｨｬ ｨｨ 09ｨｨ09ｨｰ02ｨｬｨｪ04ｨｬ ｨｨｨｬｨｬｨｮｨｪｨｪ04ｨｬ ｨ 0302ｨｪｨｨ02ｨｬ 09ｨｪｨｮｨｰ0802ｨｪｨｪｨｨ ｨ ｨｪ0609, ｨｺ06ｨｰ060804ｨｬ 09ｨｰ08ｨ 01ｨ 02ｨｰ 0708ｨｨｨ 05ｨｨ04ｨｨｨｰ0205ｨｹｨｪ06 1% ｨｪｨ ｨｪｨｨ07 [1]1 7 01ｨｨ0806ｨｺ ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰｨ (0006) ﾂ02ｨｪｨｨ ｨｬｨ ｨｰ06ｨｨ01ｨｪ ｨ 08ｨｰ08ｨｨｨｰｨ ｨｨ0506 ｨｨ04ｨｬ02ｨｪｨｨｨｰｨｹ ｨｪ ｨｰ ｨ ｨ ｨ ｨｪｨｨ ｨｨ02ｨｨｨｦ 0106ｨｺｨ 04ｨ ｨｰ0205ｨｹｨｪ06ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ04, ｨｰ ｨｰ04ｨｬ 09ｨｰｨ ｨｪ01ｨ 08ｨｰ06ｨｬ ｨｨ ｨ ｨ 04ｨｨ09ｨｪ ｨｰｨｨ ｨ 05ｨｨｨｰ0205ｨｹｨｪ ｨ 08ｨ ｨｰ ﾂ02ｨｪｨｨ , ｨｨｨｪ01ｨｮｨｺ02ｨｨｨｨ 08ｨ ｨｪｨｪ ｨｬｨ ｨｰ06ｨｨ01ｨｪ ｨ 08ｨｰ08ｨｨｨｰｨ [2ｨC9] ｨｺｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ 08ｨ ｨｰｨ, ｨｬ0603ｨｪ0609ｨｰｨｹ ｨｺ ｨｺ02ｨｨｨｨ , ｨｪｨｨ04ｨｺｨ 07 ﾂｨ 09ｨｰ06ｨｰｨ 0905ｨｮ ﾂｨ 0209 ｨｪ ｨｪ0609ｨｨｨｬ0609ｨｰｨｨ ｨｰ ｨｨｨｰｨｹ ｨｰ0208ｨ 07ｨｨ ｨｪ ｨｪ06 09 ｨｰ02- ﾂ02ｨｪｨｨ ｨ 0502ｨｰ [2] ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺ02 ﾂｨ ｨｴ ｨｨ ｨｹ040609ｨ ｨ 05ｨｹｨｪ06, 0601ｨｪｨ ｨｺ ｨｪｨｨ ｨｪｨ ｨ ｨ 02ｨｰ0907 ｨｰ02ｨｪ0102ｨｪ02ｨｨ07 ｨｺ ｨ ｨｨ0806ｨｺ06ｨｬｨｮ ｨｨ ｨｹ040609ｨ ｨｪｨｨ ｨｺ0603ｨｪ06ｨｦ ｨｬ ｨ 08ｨ ｨｰｨ [7, 8] ｨｨｨｬｨｮｨｴ0209ｨｰ ｨ 0802ｨｪｨｰ0208ｨ 05ｨｹｨｪ ｨｪｨｨ ｨ 08ｨ ｨｰｨ 06ｨ ｨｮ ｨｪ06 ｨｪ02 ｨｰ0605ｨｹｨｺ ｨｦ ｨ ｨｨ ｨｰｨｮ07ｨｪ0609ｨｰｨｹ06, ｨｪ06 ｨｨ ｨｪｨ 08ｨ 09ｨｰｨ ｨｪｨｨ02ｨｬ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨC78% 0905ｨｮ ﾂｨ ｨｨ ｨ 02ｨｨ02ｨｪｨｰ ｨ 0802ｨｪｨｰ0208ｨ 05ｨｹｨｪ ｨｪｨ ｨ 05ｨｹｨｪ04ｨｦ 0708ｨｨ02ｨｬ [9] ｨｨｨｨ ｨｺ0603ｨｪ ｨｪｨｨ ｨ 08ｨ ｨｰ 04ｨ ｨｨ09ｨｰ08ｨｨ080609ｨ ｨｪ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｰ ｨｪｨ ｨｬｨｪ0600ｨｨｨｬｨｨ 06ｨｰｨｺ0804ｨｰ04ｨｬｨｨ ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｬ04ｨｬｨｨ ｨｨ ｨ ｨｪｨｨ07ｨｬｨｨ, ｨｨｨｪｨｰ ｨｰｨ ｨｰ 0908ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ0402 ｨｨ ｨ ｨｪｨｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰｨ 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ ｨ ｨ ｨｪｨｨ07 [7ｨC9] ｨｹ ｨｨ ｨ ｨｪｨｨ07: ｨｨ04ｨｮ ﾂｨｨｨｰｨｹ 0905ｨｨ07ｨｪｨｨ02 ｨｨｨｪｨｲ02ｨｺ02ｨｨ06ｨｪｨｪ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰｨ ｨｪｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｬｨ ｨｰ06ｨｨ01ｨｪ ｨ 08ｨｰ08ｨｨｨｰｨ ｨｨｨｬ02ｨｪ02ｨｪｨｨ02ｨｬ ｨｨｨｪ0102ｨｺ09ｨ DAS ｨ ｨｰ0208ｨｨｨ 05 ｨｨ ｨｬ02ｨｰ ｨｨ ｨ ｨｪｨｨ ｨｮ0707ｨｮ ｨｨ ｨ ｨｪｨｨ ｨｨ 79 ｨ 0605ｨｹｨｪ ｨｰ ｨｪ04ｨｬ ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨｨ ｨｬｨ ｨｰ06ｨｨ01ｨｪ ｨ 08ｨｰ08ｨｨｨｰｨ ｨｨ ｨｹ040609ｨ 05ｨｨ09ｨｹ ｨｺ08ｨｨｨｰ0208ｨｨｨｨ ACR/EULAR (2010) ｨｪｨｨｨｬ ｨｨ04 ｨｺ08ｨｨｨｰ0208ｨｨ ｨｺ0506 ﾂ02ｨｪｨｨ07 ｨ ｨ 09ｨｨ02 ｨ 0605ｨｹｨｪ ｨｪｨ ｨｮ ﾂｨ 09ｨｰｨｨ02 09 ｨｨ ｨ ｨｪｨｨｨｨ, ｨｨ09ｨ ｨｪｨｨ02 ｨｨｨｪ000608ｨｬｨｨ080609ｨ ｨｪｨｪ ｨ 09ｨｨ ｨ 09ｨｰ ｨ 0605ｨｹｨｪ ｨ 08ｨｹｨｨ080609ｨ 05 06ｨｰ ｨｰ ( ｨｪ02ｨｬ 45, ｨｰ) ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 04ｨ ｨ ｨ ｨｪｨｨ ｨｰｨ ｨ 06ｨｰ ｨｰ ( ｨｪ02ｨｬ 14, ｨｰ)1 7 08ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｪｨｨ09ｨ 05ｨ 09ｨｹ 0706 ｨｨｨｪ0102ｨｺ09ｨｮ DAS28, 0802ｨｺ06ｨｬ02ｨｪ010609ｨ ｨｪｨｪ06ｨｬｨｮ ｨｨｨ 02ｨｨ02ｨｦ ｨｬｨ ｨｰ ｨｨｨｨ ( ｨ 0906ｨｪ0609, 2005) ｨｨ EULAR (1999)1 7 05ｨｪｨ ﾂ02ｨｪｨｨ02 DAS28 5, ｨｰ0902ｨｰ09ｨｰ09ｨｮ02ｨｰ ｨｺ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ, DAS28 3,2 ｨC ｨｮｨｬ020802ｨｪｨｪ06-ｨｪｨｨ04ｨｺ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ, DAS28 2,6 ｨｨ ｨｬ02ｨｪ ｨｰ0902ｨｰ09ｨｰ09ｨｮ02ｨｰ 0802ｨｬｨｨ0909ｨｨｨｨ ｨｪｨｺｨ 06ｨｰ0902ｨｰｨ ｨｪｨ 0502 ﾂ02ｨｪｨｨ ｨｺ08ｨｨｨｰ0208ｨｨ07ｨｬ EULAR (ｨｪｨ 0609ｨｪ DAS28):0708ｨｨ ｨｺ06ｨｪ02 ﾂｨｪ06ｨｬ 04ｨｪｨ ﾂ02ｨｪｨｨｨｨ DAS28<3,2: ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 DAS28 ｨｪｨ >1,2 ( ｨｨｨｦ); 0,6ｨC1,2 (ｨｮ ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ); <0,6 (ｨ ｨｺｨｰｨ ); 0708ｨｨ ｨｺ06ｨｪ02 ﾂｨｪ06ｨｬ 04ｨｪｨ ﾂ02ｨｪｨｨｨｦ DAS28 3,2ｨC5,1: ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 DAS28>1,2 (ｨｮ ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ); 0,6ｨC1,2 (ｨｮ ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ); <0,6 (ｨ ｨｺｨｰｨ ); 0708ｨｨ ｨｺ06ｨｪ02 ﾂｨｪ06ｨｬ 04ｨｪｨ ﾂ02ｨｪｨｨｨｨ DAS28>5,1: ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 DAS28>1,2 (ｨｮ ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ); 0,6ｨC1,2 (ｨ ｨｺｨｰｨ ); <0,6 (ｨ ｨｺｨｰｨ )1 7 05ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨ 07 06ｨ 08ｨ ｨ 06ｨｰｨｺｨ ｨｮ ﾂ02ｨｪｨｪ ｨ ｨｪｨｪ ｨｨ05ｨ 09ｨｹ ｨｪｨ ｨｪｨ 05ｨｹｨｪ06ｨｬ ｨｺ06ｨｬ07ｨｹ06ｨｰ ｨｨ ｨｹ040609ｨ ｨｪｨｨ02ｨｬ ｨ ｨｬｨｬ04 SPSS ｨC PASW Statistic ｨｨｨｬ02ｨｪ0705ｨｨ09ｨｹ ｨｬ02ｨｰ ｨｨ09ｨ ｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨｨｺｨｨ, ｨｪ0207ｨ 08ｨ ｨｬ02ｨｰ08ｨｨ ﾂ0209ｨｺｨｨ02 ｨｬ02ｨｰ060104, ｨｺ08ｨｨｨｰ0208ｨｨｨｦ 05ｨｰｨｹ060102ｨｪｨｰｨ ｨｰ ｨｪ04ｨｬｨｨ 09 ﾂｨｨｨｰｨ 05ｨｨ09ｨｹ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｨ ｨｮ080609ｨｪ02 04ｨｪｨ ﾂｨｨｨｬ0609ｨｰｨｨ 08<0, ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ 06ｨ 09ｨｮ030102ｨｪｨｨ ｨｮ ｨｪｨ ｨ ｨｪｨｨ ｨ 05ｨ 01ｨ 05ｨｨ 0302ｨｪｨｴｨｨｨｪ04 ｨC 67 (84,8%) (ｨｰｨ ｨ ) ｨｨ ｨ 02ｨｨ02ｨｪｨｰ0609, ｨｮ 34 (43,0%) ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｰ0902ｨｰ09ｨｰ090609ｨ 05ｨ II 09ｨｰ020702ｨｪｨｨ, ｨｮ 45 (57,0%) ｨC III 09ｨｰ020702ｨｪｨｨ 0706 DAS ｨ 02ｨｨ02ｨｪｨｰ ｨｮ ﾂｨ 05ｨｨ ｨｺ0603ｨｪ06, 0708ｨｨ ｨｬ 09ｨｨ04ｨｨｨｰ ｨ ｨｨ08ｨ 05ｨ 09ｨｹ ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨ 05ｨｹｨｪｨ ｨｺｨｰｨｨ09ｨｪｨ ｨ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰｨ 06ｨｰ ｨｬ00/ｨｪ ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ ｨ ｨｪｨｨ ｨ 02ｨｨ02ｨｪｨｰ04 ｨｪｨ ｨ ｨ 05ｨｨ09ｨｹ ｨｺｨ ｨｬ ｨ ｨｪｨｨ07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ ｨ ｨｪｨｨ07 ｨｨ ｨｬ06ｨｪｨｨｨｰ0608ｨｨ080609ｨ ｨｪｨｨ ｨ 06 ﾂｨｪ ｨｺｨｰｨ ｨ 08ｨ ｨｰｨ ｨｨ 09ｨｰ060806ｨｬ 09ｨｨ04ｨｨｨｰ ｨ ｨｴ02ｨｦ 0008ｨｮ ｨｪｨ ｨ ｨｪｨｨ ｨｪｨ ｨｰ02ｨｪ0102ｨｪ02ｨｨ07 ｨｺ 09ｨｪｨｨ0302ｨｪｨｨ06 07ｨ 08ｨ ｨｬ02ｨｰ08ｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ, ｨｨｨｪ0102ｨｺ09 DAS ｨｰｨ 09ｨｨ05 4,29 ﾀ1, ｨｰｨｨ09 ｨｨ ｨｪ ｨｪｨ ﾂ02ｨｪｨｨ07 07ｨ 08ｨ ｨｬ02ｨｰ08ｨ 5,11 ﾀ1,17 (ｨｰｨ ｨ ) ｨ 02ｨｨ02ｨｪｨｰ ｨｺ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 12 (26,7%) ｨｪ02 06ｨｰ0902ｨｰｨｨ05ｨｨ ｨｪｨ 0502 ﾂ02ｨｪｨｨ02 (09ｨｪｨｨ0302ｨｪｨｨ DAS ｨｰｨ 09ｨｨ0506 ｨｪ02 ｨ ,6), ｨｮ 33 (73,3%) ｨｪｨ ｨ ｨ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨｺｨｰ (09ｨｪｨｨ0302ｨｪｨｨ02 06ｨｰ 0, ,2) ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ09ｨ 23 (67,6%) 07ｨ 02ｨｨ02ｨｪｨｰ ｨｪ02ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0708ｨｨ 09ｨｰ060806ｨｬ, ｨｰ0802ｨｰｨｹ02ｨｬ ｨｨ ﾂ02ｨｰ090208ｨｰ06ｨｬ 09ｨｨ04ｨｨｨｰ02 ｨｪｨ 0006ｨｪ02 ｨｰ0208ｨ 07ｨｨｨｨ ｨ 00ｨｨｨｺ09ｨｨ080609ｨ ｨｪ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨｺｨｰ ｨ 08ｨ ｨｰｨ (09ｨｪｨｨ0302ｨｪｨｨ DAS ｨｰｨ 09ｨｨ0506 ｨｬ02ｨｪ0202 0,6), ｨｰ0605ｨｹｨｺ06 ｨｮ 11 (32,3%) 07ｨ 02ｨｨ02ｨｪｨｰ ｨｰｨｬ02 ﾂ02ｨｪ ｨｮ ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨｺｨｰ ｨｨ ｨｰ0802ｨｰｨｹ02ｨｬ ｨｨ ﾂ02ｨｰ090208ｨｰ06ｨｬ 09ｨｨ04ｨｨｨｰ ｨ ｨｴ02ｨｦ 0008ｨｮ ｨ 02ｨｨ02ｨｪｨｰ0609, ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ06 06ｨｰ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0408, 06ｨｰｨｬ02 ﾂ02ｨｪ ｨｮ ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨｺｨｰ ｨ 08ｨ ｨｰｨ ｨC ｨｪｨ ｨ ｨ ｨｹ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ ｨｪｨｨ0302ｨｪｨｨ02 DAS ｨｪ06ｨｬｨｮ 0904ｨ ﾂｨｪ06ｨｬｨｮ t-ｨｺ08ｨｨｨｰ0208ｨｨ06 (04<0,001), 04ｨｪｨ ﾂ02ｨｪｨｨ ｨｰｨ 09ｨｨ05ｨｨ 3,63 ﾀ1,01 ｨｨ 3,16 ﾀ0, ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ ｨｨ 0707ｨｰ06ｨｬ 09ｨｨ04ｨｨｨｰ ｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｪ02ｨｦ 09ｨｰ020702ｨｪｨｹ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 06ｨｰｨｬ02 ﾂｨ 02ｨｰ ｨｰ ｨｪｨ ｨｨｨｰ0205ｨｹｨｪｨ 07 01ｨｨｨｪｨ ｨｬｨｨｨｺｨ ｨｮ 18 (53,0%), ｨｨｨｪ0102ｨｺ09 ｨ ｨｺ- Q Q Q '$6 ｰ ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｯ 0308ｨｨ ｨｪｨｨ02

7 '$6 ｰ6' '$6 ｰ ｰ ｰ ｰ ｰ ｨｰｨｨ09ｨｪ0609ｨｰｨｨ DAS ｨｰｨ 09ｨｨ05 ｨｬ02ｨｪ0202 2,6, ﾂｨｰ ｨｰ0902ｨｰ09ｨｰ090609ｨ 0506 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 0802ｨｬｨｨ0909ｨｨｨｨ (0706 ｨｺ08ｨｨｨｰ0208ｨｨ07ｨｬ ｨｦ09ｨｺ06ｨｦ 05ｨｨ00ｨｨ ｨｬｨ ｨｰ ), ｨｮ 16 (47%) 07ｨ 02ｨｨ02ｨｪｨｰ ｨ 00ｨｨｨｺ09ｨｨ080609ｨ ｨｪｨ ｨｮｨｬ020802ｨｪｨｪ06-ｨｪｨｨ04ｨｺｨ 07 09ｨｰ020702ｨｪｨｹ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ ｨ ｨｪｨｨ ｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｺ06ｨｦ 09ｨｰ020702ｨｪｨｹ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｮ 31 (68,9%) ｨｪｨ 09ｨｰｨｮ07ｨｨ05ｨ ｨｪ ｨｪｨ ｨｬｨｨ0909ｨｨ07 (ｨｨｨｪ0102ｨｺ09 ｨ ,6), ｨｰ0605ｨｹｨｺ06 ｨｮ 14 (31,1%) 07ｨ 02ｨｨ02ｨｪｨｰ ｨｰｨｬ02 ﾂ02ｨｪ ｨｨｨｪ0102ｨｺ09 DAS28 ｨｬ02ｨｪ0202 2, ｨ 0707ｨｰ06ｨｬ 09ｨｨ04ｨｨｨｰ ｨ ｨｴ02ｨｦ 0008ｨｮ ｨｪｨ ｨ ｨｪｨｨ07 DAS ｨｰｨ 09ｨｨ05 2,74 ﾀ0,79, ﾂｨｰ ｨｰ0902ｨｰ09ｨｰ09ｨｮ02ｨｰ ｨｪｨｨ04ｨｺ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ (0708ｨｨ 0908ｨ 09ｨｪ02ｨｪｨｨｨｨ 09 07ｨ 08ｨ ｨｬ02ｨｰ0806ｨｬ 0708ｨｨ ﾂ02ｨｰ090208ｨｰ06ｨｬ 09ｨｨ04ｨｨｨｰ02 04ｨ ｨｨ09ｨｰ08ｨｨ080609ｨ ｨｪ06 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｪｨ 0,42) ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ06 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 ｨｨｨｪ0102ｨｺ09ｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ ｨ ｨｪｨｨ07 DAS28 ｨｪｨ 2,37 06ｨｰ ｨｨ ｨｪ ｨｮ080609ｨｪ ｨｺｨ ｨ 02ｨｰ ｨｮ ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨｺｨｰ ｨ 08ｨ ｨｰｨ ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｪｨ ｨｨ ｨ ｨｪｨｨ ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｬ ｨ 08ｨｰ08ｨｨｨｰ06ｨｬ ﾂ ｨｬ ｨ ｨｰ0208ｨ 07ｨｨｨｨ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰ06ｨｬ ｨｪｨ ｨ ｨ ｨｹ 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｨｨｪ0102ｨｺ09ｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ DAS28, ﾂ ｨｬ ｨｮ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ09ｨ ｨ 0605ｨｹｨｪ ｨ 00ｨｨｨｺ09ｨｨ080609ｨ ｨｪｨ ｨｪｨｨ04ｨｺｨ 07 09ｨｰ020702ｨｪｨｹ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｬｨ ｨｰ06ｨｨ01ｨｪ ｨ 08ｨｰ08ｨｨｨｰｨ, 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｴｨ 07 06ｨ ｨｮ ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ06ｨｬ ｨｺｨｰ ｨ 08ｨ ｨｰｨ, ﾂｨｰ ｨｨｨｰ ｨｮ05ｨｮ ﾂ03ｨｨｨｰｨｹ ｨｪ ｨｰ ｨｰ ｨ ｨ ｨ ｨｪｨｨ ｨｬｨ ｨｰ ｨｨ07: 0805ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ ｨｺ06ｨｬ02ｨｪ01ｨ 02ｨｨｨｨ / ｨ 0906ｨｪ0609ｨ, 001 7: ｨｨｨ, 2011, ｨ 0906ｨｪ0609 E ﾂ02ｨｪｨｨ ｨｬｨ ｨｰ06ｨｨ01ｨｪ ｨ 08ｨｰ08ｨｨｨｰｨ 2012: ｨｬ0209ｨｰ06 ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰｨ ｨ ｨｮ ﾂｨｪ ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨ ｨｬｨ ｨｰ ｨｨ ;2 (0708ｨｨ ｨｪｨｨ02 1): Weslake S1 7L1 7, Imamura F1 7, Wyler von Ballmoos M1 7 [et al1 7] The effect of methotrexate on cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review1 7 Rheumatology (Oxford) ;49(2):295ｨC DOI: /rheuma- tology/ kep Epub 2009 Nov Halla J1 7T1 7, Hardin J1 7G1 7 Under-recognized post-dosing reactions to methotrexate in patients with rheumatoid arthritis1 7 J Rheumatol ;21(7):1224ｨC Aydintung A1 7O1 7, D ｯCruz D1 7, Cervera R1 7 [et al1 7] Lowdose methotrexate treatment in adult Still ｯs disease1 7 J Rheumatol ;19(3):431ｨC Kraus A1 7, Alarcon-Segovia D1 7 Fever in adult onset Still ｯs disease1 7 Response to methotrexate1 7 J Rheumatol ;18(6):918ｨC Hoekstra M1 7, Haagsma C1 7, Neef C1 7 [et al1 7] Bioavailability of high dose methotrexate comparing oral and subcutaneous administration in patients with rheumatoid arthritis1 7 J Rheumatol ;31:645ｨC Stamp L1 7K1 7, Barclay M1 7L1 7, O ｯDonnell J1 7L1 7 [et al1 7] Effects of changing from oral to subcutaneous methotrexate on red blood cell methotrexate polyglutamate concentrations and disease activity in patients with rheumatoid arthritis1 7 J Rheumatol ;38(12):2540ｨC 71 7 DOI: 7doi1 7org/ %2Fjrheum ｨｮ08ｨ 09ｨｹ , 0202ｨｪｨｨ , ｨｺ ｨ [ｨｨ ] 02ｨｰｨｺ0804ｨｰ0602 ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｬ ｨ ｨｪ0106ｨｬｨｨ04ｨｨ080609ｨ ｨｪｨｪ ｨｪ ｨｹｨｪ ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ0602 ｨｨ ｨ ｨｪｨｨ02 ｨｨｨｪｨｲ02ｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｨ ｨｰｨ ｨ 0502ｨｰｨｨ080609ｨ ｨｪｨｪ06ｨｦ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ ｨｬ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰｨ 0708ｨｨ ｨｬｨ ｨｰ06ｨｨ01ｨｪ06ｨｬ ｨ 08ｨｰ08ｨｨｨｰ ｨ ｨｮ ﾂｨｪ ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨ ｨｬｨ ｨｰ ｨｨ ;5: ASSESSMENT OF RESPONSE TO TREATMENT WITH METHOTREXATE BASED ON ACTIVITY INDEX DAS28 IN RHEUMATOID ARTHRITIS Abisheva S1 7T1 7, Serikova Zh1 7B1 7, Sarbalinova G1 7K1 7, Alibekova G1 7A1 7, Dosaeva L1 7O1 7 Astana Medical University JSC, Astana, Republic of Kazakhstan The article presents the results of evaluating the effectiveness of treatment of rheumatoid arthritis with methotrexate using DAS28 disease activity index1 7 This study demonstrated the effectiveness of the treatment of patients with rheumatoid arthritis as to statistically significant reduction in the dynamics of the disease activity according to DAS28 activity index1 7 Keywords: rheumatoid arthritis, DAS28 disease activity index, methotrexate ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｯ 0308ｨｨ ｨｪｨｨ02 7

8 FOXP ｨ, ｨｮｨ , ｨｺ0609ｨ, ｨｦｨｺｨ ｨｪ0609, ｨｺ09ｨ ｨｪ ｨ, ｨ 0906ｨｪ ｨ 05ｨｹｨｪ ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ0602 ｨ ｨｰｨｪ0602 ｨｪｨ ｨｮ ﾂｨｪ0602 ｨｮ ﾂ ｨｪｨｨ ｨ ｨｮ ﾂｨｪ06-ｨｨ ｨ ｨｰ0205ｨｹ09ｨｺｨｨｨｦ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｬｨ ｨｰ ｨｨｨｨ ｨｨｨｬ02ｨｪｨｨ ｨ 0906ｨｪ060906ｨｦ03 ( ｨｨｨｬ ｨ 0906ｨｪ060906ｨｦ), ｨｺ09ｨ, ｨｨｨｦ09ｨｺｨ ｨ 02ｨｨ07 08ｨ ｨｺｨｮ05ｨｹｨｰ02ｨｰ 00ｨｮｨｪ01ｨ ｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ06ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ ｨｨｨｬ ｨｬ06ｨｪ ｨ, ｨｺ09ｨ, ｨｨｨｦ09ｨｺｨ ｨ 02ｨｨ07 FoxP ｨｮ0507ｨｰ0608ｨｪ ｨｺ0502ｨｰｨｺｨｨ ( ) ｨｨ0008ｨ 06ｨｰ ｨｺ0506 ﾂ0209ｨｮ ｨｹ ｨ ｨｪｨｨｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｰ ｨ ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｺ 0906ｨ 09ｨｰ0902ｨｪｨｪ04ｨｬ ｨ ｨｪｨｰｨｨ0002ｨｪｨ ｨｬ ｨｺ0502ｨｰｨｺｨｨ ｨ ｨｪ ｨ ｨｰｨｹ 06-ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｦ ｨｨｨｬｨｬｨｮｨｪｨｪ04ｨｦ 06ｨｰ0902ｨｰ ｨｨ ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ ｨｮ05ｨｨ080609ｨ ｨｰｨｹ ｨｨｨｬｨｬｨｮｨｪｨｪ ｨ ｨｺ02ｨｨｨｨ, ｨｮ05ｨｹｨｰｨ ｨｰ02 ﾂ ｨｨｨｬ 06ｨｰ090601ｨｨｨｰ ｨｮｨｴｨ ｨｹ 09 07ｨ ｨｰ060002ｨｪ ｨ ｨｮｨｰ06ｨｨｨｬｨｬｨｮｨｪｨｪ ｨ ｨ ｨ ｨｪｨｨｨｦ ｨｨ 08ｨ ｨｪｨｪ02ｨｬ ｨｬｨ ｨｰ06ｨｨ01ｨｪ06ｨｬ ｨ 08ｨｰ08ｨｨｨｰ02 (0408) ｨｪ06 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｮ080609ｨｪ ｨｺ0502ｨｰ06ｨｺ ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｬ ｨｺ ｨｰ06ｨｺ02, ｨ ｨｰｨ ｨｺ0302 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 ｨｮ080609ｨｪ07 ｨｬｨ 08ｨｺ ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06-ｨ ｨｺｨｰｨｨ09ｨｪ , ﾂｨｰ06 ｨ ｨｨｨｨ080609ｨ ｨｹ 09 ｨ ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 04ｨ ｨ ｨ ｨｪｨｨ ﾂ ｨ : ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ, ｨｮ0507ｨｰ0608ｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ, ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 04ｨ ｨ ｨ ｨｪｨｨ071 7 FoxP ｨｮ0507ｨｰ0608ｨｪ ｨｺ0502ｨｰｨｺｨｨ ( ) ｨｨ0008ｨ 06ｨｰ ｨｺ0506 ﾂ0209ｨｮ ｨｹ ｨ ｨｪｨｨｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｰ ｨ ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｺ 0906ｨ 09ｨｰ0902ｨｪｨｪ04ｨｬ ｨ ｨｪｨｰｨｨ0002ｨｪｨ ｨｬ ｨｺ0502ｨｰｨｺｨｨ ｨ ｨｪ ｨ ｨｰｨｹ 06-ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｦ ｨｨｨｬｨｬｨｮｨｪｨｪ04ｨｦ 06ｨｰ0902ｨｰ ｨｨ ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ ｨｮ05ｨｨ080609ｨ ｨｰｨｹ ｨｨｨｬｨｬｨｮｨｪｨｪ ｨ ｨｺ02ｨｨｨｨ, ｨｮ05ｨｹｨｰｨ ｨｰ02 ﾂ ｨｨｨｬ 06ｨｰ090601ｨｨｨｰ ｨｮｨｴｨ ｨｹ 09 07ｨ ｨｰ060002ｨｪ ｨ ｨｮｨｰ06ｨｨｨｬｨｬｨｮｨｪｨｪ ｨ ｨ ｨ ｨｪｨｨｨｦ [1, 2] ｨｮ0507ｨｰ0608ｨｪ ｨｺ0502ｨｰｨｺｨｨ 05ｨｺ ｨｨ08ｨｮ06ｨｰ 03ｨｨ0806ｨｺｨｨｨｦ ｨｺｨｰ08 ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ0401 ｨｬ060502ｨｺｨｮ05, ｨｺ06ｨｰ ｨｰ ｨｨ01 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ ｨｰ ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ080609ｨ ｨｰｨｹ 05ｨｰｨｨ ｨｺ0502ｨｰｨｺｨｨ 09 ｨｺ ｨｰ06ｨｺ02 [3, 4], 0601ｨｪｨ ｨｺ ｨｨ ｨｮｨｰ ｨｮ ｨｮｨｪｨｨ ｨ 05ｨｹｨｪ ｨｪ0609ｨｰｨｪ ｨｬｨ 08ｨｺ0208ｨ, ｨｴ ｨｨｨｰｨｹ 01ｨ ｨｪｨｪｨｮ06 ｨｺ0502ｨｰ06 ﾂｨｪｨｮ06 09ｨｮｨ ｨｮ050702ｨｨ06 ｨｨ04 07ｨｮ05ｨ 06-05ｨｨｨｬ000602ｨｨｨｰ ｨ ｨｨｨ ｨｨ00ｨｨ ﾂ0209ｨｺｨｨｨｬ 09ｨｪｨｮｨｰ08ｨｨｨｺ0502ｨｰ06 ﾂｨｪ04ｨｬ ｨｬｨ 08ｨｺ020806ｨｬ ｨｺ0502ｨｰ06ｨｺ ｨｰ ｨｪ04ｨｦ 00ｨ ｨｺｨｰ0608 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ Foxp3, ｨｺ06ｨｰ060804ｨｦ ｨｨｨｬ0202ｨｰ 00ｨｮｨｪ01ｨ ｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ ｨｪｨ ﾂ02ｨｪｨｨ ｨ 0409ｨｨｨｰｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ ｨｨ ｨｨ01 ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨｪ06ｨｦ 00ｨｮｨｪｨｺ02ｨｨｨｨ [3] ｨｺｨ ﾂ0209ｨｰ ｨｪ0609ｨｰｨｪ0401 ｨｬｨ 08ｨｺ ｨｺ0502ｨｰ06ｨｺ ｨｬ0600ｨｮｨｰ ｨｨ ｨｹ040609ｨ ｨｰｨｹ0907 CD25 (a ｨｹ ｨｰ0608ｨ IL-2), CTLA-4 (CD152, cytotoxic T lymphocyte antigen 4), CD95 (Fas), CD127 low ｨｨ ｨｮ00ｨｨ ﾂ ｨｺｨ ｨｺ0502ｨｰｨｺｨｨ 06ｨｰｨｪ060907ｨｰ0907 ｨｺ 09ｨｮｨ ｨｮ050702ｨｨｨｨ CD4+Foxp3+06 ｨｺ0502ｨｰ06ｨｺ ｨｨ 06ｨｰ05ｨｨ ﾂｨ 06ｨｰ ｨｺ06ｨｦ 05ｨｺ ｨｨ02ｨｦ CD25 ｨｨ ｨｪｨｨ04ｨｺ06ｨｦ 05ｨｺ ｨｨ02ｨｦ CD127 [5, 6] ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨｨｨｰ0208ｨ ｨｰｨｮ ｨｰｨ ｨｪ06 ｨ 0605ｨｹ ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨ ｨ 06ｨｰ, ｨｴ02ｨｪｨｪ ｨｪｨｺ02 ﾂｨｨ0905ｨ ｨｨ 0002ｨｪ06ｨｰｨｨ07ｨ ｨｺ0502ｨｰ06ｨｺ 0708ｨｨ ｨ ｨｴ02ｨｬ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ0902 ｨｨ04 ｨｪｨｨ ｨｰ0907 ｨｮ090205ｨｨ- ﾂ02ｨｪｨｨ ｨ ｨｪｨｨ ｨｺ0502ｨｰ06ｨｺ 09 09ｨｨｨｪ0609ｨｨｨ 05ｨｹｨｪ06ｨｦ 03ｨｨ01ｨｺ0609ｨｰｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ [7, 8], 0601ｨｪｨ ｨｺ06 01ｨ ｨｪｨｪ ｨ ｨｮ080609ｨｪ02 01ｨ ｨｪｨｪ06ｨｦ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 09ｨｮｨ ｨｮ050702ｨｨｨｨ ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｺ080609ｨｨ ｨｹｨｬｨ ｨｰｨｨ ﾂｨｨ ｨｹ03ｨｨｨｪ09ｨｰ0906 ｨｨ ｨ ｨｰ020502ｨｦ ｨｪｨ ｨ ｨ 05ｨｨ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ ｨｪｨｰｨｪ ﾂｨｨ0905ｨ 02ｨｨ08ｨｺｨｮ05ｨｨ08ｨｮ06ｨｴｨｨ ｨｺ0502ｨｰ06ｨｺ [9, 10], 09 ｨｰ ｨｬ07 ｨｺｨ ｨｺ ｨｮ00ｨｨ01 08ｨ ｨ 06ｨｰｨ ｨｪ06 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 [11] ｨｨ05ｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ02 06ｨｰ05ｨｨ ﾂｨｨｨｦ 09 ｨｮ080609ｨｪ ｨｺ0502ｨｰ06ｨｺ 06ｨｰ ｨｪ [12] ｨ 00ｨ 06ｨｰ, ﾂｨｰ06 ｨｺ0605ｨｨ ﾂ0209ｨｰ0902ｨｪｨｪ04ｨｦ ｨｺｨｰ CD4+CD25+Foxp3+CD ｨｮ0507ｨｰ0608ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨ 02ｨｪｨｪ06 01ｨ 08ｨ ｨｺｨｰ020802ｨｪ ｨ ｨｪｨｪ ｨｨ ｨ ｨｨｨｨ08ｨｮ02ｨｰ ｨｨ09ｨｺ06ｨｬ 08ｨ 0409ｨｨｨｰｨｨ ｨｮ ｨ ｨｨｨｬ07ｨｰ06ｨｬｨｪ ｨ 02ｨｨ02ｨｪｨｰ0609, ｨｨｨｰｨｨ09ｨｪ [13]1 7 06ｨ ｨｺ ｨｨｨｰ0208ｨ ｨｰｨｮ ｨｰｨ ｨｪ ｨｰｨｨ ﾂｨｨ ｨ ｨｪｨｪ ｨ ｨｨｨｬ ｨｨ ｨｮ080609ｨｪ ｨｺ0502ｨｰ06ｨｺ 09 ｨｺ05ｨｨｨｪｨｨｨｺ0605ｨ ｨ 0608ｨ ｨｰ0608ｨｪ04ｨｬｨｨ 0706ｨｺｨ 04ｨ ｨｰ020507ｨｬｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨ ｨｺ ｨ ｨ 06ｨｰ ｨｪｨ 06ｨ 08ｨ ｨｰｨｪｨ 07 ｨｺ ｨｨ06ｨｪｨｪｨ ｨ ｨｨｨｬ ｨｹ ｨｬ020301ｨｮ DAS 28 ｨｨ ｨｪｨｰ06ｨｬ 02ｨｨ08ｨｺｨｮ05ｨｨ08ｨｮ06ｨｴｨｨ01 Foxp ｨｮ0507ｨｰ0608ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ [9]; ｨｮ0006ｨｦ 09ｨｰ060806ｨｪ ｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 04ｨ ｨ ｨ ｨｪｨｨ07 ｨ 09ｨｰ ｨｨ09ｨｰ08ｨｨ08ｨｮ06ｨｰ ｨｺ ｨ ｨｪｨｨ02 CD25+Foxp3+ 06-ｨｺ0502ｨｰ06ｨｺ [14]1 7 06ｨ ｨｺ ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ06 ｨｪｨｨ ｨｪ06ｨｦ 08ｨ ｨ 06ｨｰ02 ｨｪ ｨ 09ｨｹ ｨ ｨｨｨ 02ｨｨ07 ｨｬ020301ｨｮ ｨｪｨｰｨｪ04ｨｬ ｨ ｨｪｨｨ02ｨｬ ｨｺ0502ｨｰ06ｨｺ, ｨ ｨｰｨ ｨｺ ｨ 09ｨｰ06ｨｬ, ｨｬ, 0105ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ06 04ｨ ｨ ｨ ｨｪｨｨ07, ｨｨｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ ｨｨ ｨｨ09ｨｪ04ｨｬ ｨ 0302ｨｪｨｨ02ｨｬ 09ｨｮ09ｨｰｨ [10] ｨｹ06 ｨｪｨ 0302ｨｦ 08ｨ ｨ 06ｨｰ ｨｹ: ｨ ｨｪｨ ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｯ 0308ｨｨ ｨｪｨｨ02

9 05ｨｨ04ｨｨ080609ｨ ｨｰｨｹ ｨｪｨｰｨｪ0602 ｨｨ ｨ ｨ ｨｰｨｪ ｨ ｨｪｨｨ ｨｺ0502ｨｰ06ｨｺ ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｺ080609ｨｨ ｨｪ ｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ ｨ ｨｪｨｪｨｨｨｬ 0408 ｨｬ02ｨｰ060106ｨｬ ｨｰ06 ﾂｨｪ06ｨｦ 02ｨｨｨｰ06ｨｬ02ｨｰ08ｨｨｨｨ; ｨｪｨｨｨｰｨｹ 0904ｨ ｨｨｨｬ ｨｹ ｨｬ020301ｨｮ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906ｨｬ ｨｨ 0002ｨｪ06ｨｰｨｨ0706ｨｬ ｨｺ0502ｨｰ06ｨｺ ｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ ｨｰ0208ｨｨｨ 05 ｨｨ ｨｬ02ｨｰ060104: 00 ｨｨ ｨ ｨｪｨｨ02 ｨ ｨｺ0506 ﾂ02ｨｪ ｨ 02ｨｨ02ｨｪｨｰ0609(5 ｨｬｨｮ03 ﾂｨｨｨｪ ｨｨ ｨｪｨｴｨｨｨｪ04) 09 08ｨ ｨｪｨｪｨｨｨｬ 0408 (ｨｺ08ｨｨｨｰ0208ｨｨｨｨ ACR/EULAR ), ｨｪ ｨｮ ﾂｨ 0903ｨｨ ｨｰ09ｨｮ06ｨｴ02ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ ｨ ｨ 04ｨｨ09ｨｪ04ｨｬｨｨ ｨｰｨｨ ｨ 05ｨｨｨｰ0205ｨｹｨｪ04ｨｬｨｨ ｨ 08ｨ ｨｰｨ ｨｬｨｨ ｨｨ ｨｺ06ｨｺ0608ｨｰｨｨｨｺ06ｨｨ01ｨ ｨｬｨｨ, ｨｪｨｨｨｦ ｨ 09ｨｰ 50 (32-58) 0502ｨｰ, 0105ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 04ｨ ｨ ｨ ｨｪｨｨ07 5 (4-6) ｨｬ , ｨｬ0201ｨｨｨ ｨｪｨ DAS 28 5,1 (4,3-5,8) ｨｨｨｰｨｨ09ｨｪ0401 ｨC 26 (66,7%), ｨｨｨｰｨｨ09ｨｪ0401 ｨC 34 (87,2%)) ｨｬ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ 09 ｨｺｨ ﾂ0209ｨｰ ｨ 0405 ｨｪｨ 04ｨｪｨ - ﾂ02ｨｪ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰ (0006) 09 ｨｪｨ ﾂｨ 05ｨｹｨｪ06ｨｦ ｨｬ00/ｨｪ ｨｪｨｨ ｨｮｨｴ0209ｨｰ ｨｨ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ04ｨｬ ｨｬ020301ｨｮｨｪｨ ｨｪ04ｨｬ ｨｬ02ｨｰ060106ｨｬ ｨｰ ｨｪｨｮ (ｨｪ0608ｨｬｨ 0530 ｨｬｨｬ/ ﾂ) ｨｰ06 ﾂｨｪｨｮ06 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ ｨｨ IgM 0408 ｨｨ04ｨｬ ｨｨ ｨｨｨｬｨｬｨｮｨｪ06ｨｪ ｨｬ02ｨｰ08ｨｨ ﾂ0209ｨｺｨｨｨｬ ｨｬ02ｨｰ060106ｨｬ ｨｪｨ ｨ ｨｪｨ 05ｨｨ04ｨ ｨｰ BN ProSpec (00Siemens03, ｨｬｨ ｨｪｨｨ07) ｨｬｨ 05ｨｹｨｪ04ｨｦ ｨｮ ｨｪｨｹ ｨｰｨｺ02 ｨｺ080609ｨｨ ｨｰｨ ,0 ｨｬ00/ ｨｨｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ 00ｨｨ08ｨｬ04-ｨｨ040006ｨｰ0609ｨｨｨｰ ｨ ｨｪ ｨ ｨｪｨｨ02ｨｮ ｨｪ0608ｨｬ04 IgM 0408 ｨ 0405ｨ 0708ｨｨｨｪ07ｨｰｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07, 08ｨ 09ｨｪｨ 07 15,0 0003/ｨｬ ｨｨ ﾂ0209ｨｰ0902ｨｪｨｪ ｨｪｨｨ ｨｰｨｺ02 ｨｺ080609ｨｨ ｨｨ05ｨｨ ｨｺｨｰ ｨｬｨｨ0506ｨｬｨｨｨｪｨｨ090202ｨｪｨｰｨｪ04ｨｬ ｨｬ02ｨｰ060106ｨｬ ｨｪｨ ｨ ｨｪｨ 05ｨｨ04ｨ ｨｰ Cobas e411 (00Roche03, ｨｦ02ｨ 08ｨｨ07) ( ｨｪ ｨ ｨｪｨｨ02ｨ ｨｪ0608ｨｬ04 17,0 0302/ｨｬ05), ｨ ｨｰｨ ｨｺ0302 ｨｬ02ｨｰ060106ｨｬ ｨｨｨｬｨｬｨｮｨｪ ｨｬ02ｨｪｨｰｨｪ ｨ ｨｪｨ 05ｨｨ04ｨ ｨｬ06ｨｴｨｹ06 ｨｺ06ｨｬｨｬ0208 ﾂ0209ｨｺ ｨｪｨ ｨ 0608ｨ 0802ｨ 0002ｨｪｨｰ0609 (00Axis-Shield03, ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨ07), ｨｪ ｨ ｨｪｨｨ02ｨ ｨｪ0608ｨｬ04 ｨC 5,0 0301/ｨｬ ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ0602 ｨｨ ｨ ｨ ｨｰｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ ｨｺ0502ｨｰ06ｨｺ (FoxP3+CD25+; CD152+surface; CD152+intracellular; FoxP3+CD127-; CD25+CD127-; FoxP3+ICOS+; FoxP3+CD154+; FoxP3+CD274+) ｨｹ ｨｬ02ｨｰ060106ｨｬ ｨｬｨｪ ｨｰｨｪ06ｨｦ ｨｰ06 ﾂｨｪ06ｨｦ 02ｨｨｨｰ060005ｨｮ0608ｨｨｨｬ02ｨｰ08ｨｨｨｨ ｨｪｨ ｨ ｨｪｨ 05ｨｨ04ｨ ｨｰ BD LSR Fortessa Special Order Research Product (BD) ｨｪｨｰ080605ｨｹｨｪｨｮ ｨｮ0707ｨｮ ｨｰｨ 09ｨｨ05ｨｨ ｨｪ , ｨｰｨ 09ｨｨｨｬ ｨｮ ｨｨ ｨ 09ｨｰｨｮ 09 06ｨ ｨ ｨｪｨｪ04ｨｬｨｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬｨｨ ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ 06ｨ 09ｨｮ030102ｨｪｨｨ ｨ 02ｨｨ02ｨｪｨｰ ｨ ｨｪｨｪｨｨｨｬ ｨ 09ｨｪ02ｨｪｨｨ ｨｬｨｨ 0106ｨｪ0608ｨ ｨｬｨｨ ｨｨ09ｨｰ08ｨｨ080609ｨ ｨｹ ｨ ｨｪｨｨ04ｨｺ ｨｪｨｰｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 FoxP3+CD25+ ｨｺ0502ｨｰ06ｨｺ ((5,53 (4,09-6,48 ｨｨ 6,92 (5,84-7,96)), ｨｪｨｰｨｪ0602 ｨｨ ｨ ｨ ｨｰｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 FoxP3+ICOS+ ｨｺ0502ｨｰ06ｨｺ ((6,91 (2,14-11,47) ｨｨ 10,83 (9,27-13,7); 0,0035 (0,0013-0,0067) ｨｨ 0,0068 (0,0039-0,009)), ｨｪｨｰｨｪ0602 ｨｨ ｨ ｨ ｨｰｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 FoxP3+CD154+ ｨｺ0502ｨｰ06ｨｺ ((0,47 (0,19-0,83) ｨｨ 1,51 (1,12-2,08); 0,0002 (0, ,0005) ｨｨ 0,00087 (0, ,0014)) ｨｨ FoxP3+CD ｨｺ0502ｨｰ06ｨｺ (0,63 (0,34-1,49) ｨｨ 1,94 (1,16-2,25); 0,0003 (0,0002-0,00065) ｨｨ 0,001 (0,0006-0,0016), p<0, ｨｮ ﾂｨ 0701) (08ｨｨ ) ｨｨ09ｨｰ08ｨｨ080609ｨ 05ｨ 09ｨｹ 06ｨｰ08ｨｨ02ｨ ｨｰ0205ｨｹｨｪｨ 07 ｨｺ ｨｨ06ｨｪｨｪｨ ｨ ｨｨｨｬ ｨｹ: ｨｪｨｰｨｪ ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ FoxP3+CD (r = -0,4) ｨｨ (r = -0,43); 0308 CD152+ intracellular 09 DAS 28 (r = -0,4), (r = -0,52) (r = -0,55); 0308 FoxP3+CD (r = -0,41), (r = -0,48); 0308 CD25+CD DAS28 (r = -0,53), SDAI (r = -0,5), CDAI (r = -0,44), (r = -0,56), (r = -0,53), 08<0, ｨｮ ﾂｨ ｨｮ ｨ 02ｨｨ02ｨｪｨｰ ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 04ｨ ｨ ｨ ｨｪｨｨ07 (DAS 28>5,1 SDAI>26 CDAI>22, n=27) ｨｨ09ｨｰ08ｨｨ080609ｨ ｨｹ ｨ ｨｪｨｨ04ｨｺ ｨｪｨｰｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 CD25+CD ｨｺ0502ｨｰ06ｨｺ ｨ 09ｨｪ02ｨｪｨｨ06 09 ｨ 0605ｨｹｨｪ04ｨｬｨｨ 09 ｨｪｨｨ04ｨｺ06ｨｦ/ｨｮｨｬ020802ｨｪｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 07ｨ ｨｰ ｨｨ ﾂ0209ｨｺ ｨ (5,1; 4,9-5,6 ｨｨ 6,9; 6,4-7,9, P<0,05) (08ｨｨ )1 7 04ｨｨ ｨｪｨｰｨｪ ｨ ｨｪｨｨ02 09ｨｮｨ ｨｮ050702ｨｨｨｦ ｨｺ0502ｨｰ06ｨｺ ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｺ080609ｨｨ ｨ 0605ｨｹｨｪ ｨｨ ｨｪ ｨｨ ｨｪｨｰｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 CD25+CD ｨｺ0502ｨｰ06ｨｺ ｨｮ0707ｨ 01 07ｨ 02ｨｨ02ｨｪｨｰ ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ ｨ ｨｪｨｨ ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ ｨ ｨ ｨｪ02ｨｪｨｨ ｯ 0308ｨｨ ｨｪｨｨ02 9