cit_5.vp

Transcription

1 ｨｬ49, FtsZ ｨｨ03ｨｪ07ｨｺ0609, ｨｪｨｨｨｮ ｨｨ03ｨｪ07ｨｺ0609, ｨｪｨｨｨｮ ｨｺ FtsZ ｨｨ 02ｨｨｨｰ06ｨｺｨｨｨｪ0204 ｨｮ ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ 06ｨｪ09ｨｰｨｨｨｰｨｮｨｰ 02ｨｨｨｰ ｨｨｨｨ , 05ｨ ｨｪｨｺｨｰ-0302ｨｰ0208ｨ ｨｮ0800; ｨｺｨｰ0806ｨｪｨｪ04ｨｦ ｨ : 00 06ｨ ｨ 0909ｨｬ06ｨｰ0802ｨｪ04 ｨ 0205ｨｺｨｨ ｨｨ ｨｪｨ 01ｨｬ060502ｨｺｨｮ050708ｨｪ ｨｰ08ｨｮｨｺｨｰｨｮ0804, ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｴｨｨ ｨｪｨｨ07 ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｺ0502ｨｰｨｺｨｨ ﾂ020904ｨｬ ｨ 0205ｨｺ06ｨｬ ｨｪｨｨ07 ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ09ｨ ｨｺｨ 08ｨｨ06ｨｰ ｨｰ0907 ｨ ｨｺ FtsZ ｪ 0006ｨｬ ｨｰｨｮｨ ｨｮ05ｨｨｨｪｨ 05ｨｮｨｺｨ 08ｨｨ06ｨｰ, ｨ ｨｪ04ｨｦ ｨ ｨｰｨｹ ｨｨ 00ｨｨ ｨｨ040609ｨ ｨｰｨｹ ｨｪｨｨ02 ｨｺ0502ｨｰｨｺｨｨ ｨｪｨ ﾂｨｨｨｪｨ 02ｨｰ ｨ 08ｨ ｨ ｨｪｨｨ07 ｨｰｨ ｨｺ ｨｪｨ ｨ 02ｨｬ06ｨｦ 01ｨｨ09ｨｨ0906ｨｬ04, 0609ｨｪ0609ｨｮ ｨｺ06ｨｰ060806ｨｦ ｨｰｨ ｨｰ ｨｺ0605ｨｹ ｨ ｨｰｨｨ07 (Z-ｨｺ0605ｨｹ0206), ｨ 06ｨｴ0202 ｨｺ0502ｨｰｨｺｨｮ 0708ｨｨｨｬ0208ｨｪ ｨｨｨｪ ｨｹ ｨｰｨ ｨｰ 0906ｨ 06ｨｦ 07ｨｮ ﾂ06ｨｺ 05ｨ ｨｰ0208ｨ 05ｨｹｨｪ ｨ ｨｪｨｪ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609, 06ｨ 08ｨ 04ｨｮ06ｨｴｨｨ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ ｨ 0205ｨｺｨ FtsZ ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ0602 Z-ｨｺ0605ｨｹ ｨｰｨｺ ｨ ｨｪ06 09 ｨｬ02ｨｬｨ 08ｨ ｨｪ06ｨｦ 0708ｨｨ ｨｮ ﾂｨ 09ｨｰｨｨｨｨ FtsA, ZipA, FtsW ｨｨ ｨｬｨｪ0600ｨｨ ｨｮ00ｨｨ ｨｬ0600ｨ ｨｰ0205ｨｹｨｪ ｨ 0205ｨｺ ｨｪｨｨ07, ｨｴｨｨ ｨｰｨ 09 01ｨｨ09ｨｨ0906ｨｬ ｨｹ0206 ｨｪｨ 0708ｨ ｨｰ ｨｨｨｰ06ｨｺｨｨｨｪ0204ｨ, ｨ 09ｨ 07 ｨｪｨ ｨｬ02ｨｬｨ 08ｨ ｨｪｨｮ 09ｨｨ05ｨｮ 0903ｨ ｨｰｨｨ ｨｨ ﾂｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ ｨｬ02ｨｦ09ｨｰ ｨｺｨ 08ｨｨ06ｨｰｨｪ0401 FtsZ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 06ｨｰ05ｨｨ ﾂｨ 02ｨｰ ｨｰ 05ｨｮｨｺｨ 08ｨｨ06ｨｰｨｪ0401 ｨｰｨｮｨ ｨｮ05ｨｨｨｪ0609, 04ｨ ｨｨ09ｨｺ0506 ﾂ02ｨｪｨｨ02ｨｬ 06ｨ 05ｨ 09ｨｰｨｨ 09ｨ ｨｦｨｰｨ ｨ ｨｪｨｨ , 0706 ｨｺ06ｨｰ060806ｨｦ 06ｨｪｨｨ ｨｺ06ｨｦ 09ｨｰ020702ｨｪｨｨ 0006ｨｬ ｨｨ ﾂｨｪ04. FtsZ ｨｰ ｨｪｨｨｨｬ ｨｨ04 09ｨ ｨｬ0401 ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪ0401 ｨ 0205ｨｺ0609 ｨｮ ｨｺｨ 08ｨｨ06ｨｰ, 0601ｨｪｨ ｨｺ ｨｪ04 ftsz ｨｪ02 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ04 ｨｮ ｨｪ02ｨｺ06ｨｰ ｨｨ010609, 0002ｨｪ06ｨｬ04 ｨｺ06ｨｰ ｨｪ0609ｨｰｨｹ ｨｺ0902ｨｪｨｨ080609ｨ ｨｪ ｨｨ ｨｰｨ ｨｺｨｨ ｨ ｨｪｨｨ04ｨｬ ｨｨ01ｨ ｨｬｨｨｨｺ060705ｨ 04ｨｬ (Ureaplasma parvum ｨｨ Mycoplasma mobile), Prostecobacter dejongeii, 10 09ｨｨ ｨ ｨｬｨｨ01ｨｨｨｦ ｨｨ 5 09ｨｨ ｨ ｨｦ. 06ｨｰｨｨ ｨ ｨｪｨｨ04ｨｬ04, ｨ ｨｰ0205ｨｹｨｪ06, ｨｰ0907 ｨ 0204 ｨｮ ﾂｨ 09ｨｰｨｨ07 FtsZ ｨｪ06ｨｬｨ ｨｮ01 ｨｪｨ 0409ｨ ｨｪｨｪ0401 ｨｬｨｨｨｺ060705ｨ 04ｨｬ ｨｨｨｬ0202ｨｰ0907 ｨｬｨｪ ｨｰｨｺ0804ｨｰ ｨ ｨｬ06ｨｺ 09 ﾂｨｨｨｰ0409ｨ ｨｪｨｨ07, ｨｺ0601ｨｨ08ｨｮ06ｨｴｨｨ01 ｨ 0205ｨｺｨｨ, ｨｺ06ｨｰ060804ｨｬ 0706ｨｺｨ ｨｪ02 ｨｮ01ｨ 02ｨｰ ｨｨ07ｨｨ09ｨ ｨｰｨｹ ｨｺｨ ｨｺｨｮ06-05ｨｨｨ 06 00ｨｮｨｪｨｺ02ｨｨ06, ｨ 0708ｨｨ 0908ｨ 09ｨｪ02ｨｪｨｨｨｨ ｨｨ ｨｨ ﾂｨｪ ｨｰ08ｨｮｨｺｨｰｨｮ08 ｨｪ02 ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ08ｨｮ02ｨｰ0907 ｨｪｨｨ 0601ｨｨｨｪ ｨｨ04 ｨ 0205ｨｺ ｨｪｨｨ ｨ 00ｨ 02ｨｬ, ﾂｨｰ ｨｪｨｨ07 05ｨｰｨｨ ｨ ｨｪｨｨ04ｨｬ ｨｪ04 ｨ 04ｨｰｨｹ ﾂ02ｨｪ04 ｨ 0205ｨｺｨｨ, ｨｪ0706ｨｴｨｨ02 00ｨｮｨｪｨｺ02ｨｨ06, ｨｪｨｮ06 09 ｨｰｨ ｨｺ060906ｨｦ ｨ 0205ｨｺｨ FtsZ, ｨｨ 0006ｨｬ ｨｨ ﾂｨｪ ｨｰ06ｨｬｨｮ ｨｨ05ｨｨ 0108ｨｮ00ｨｨｨｬ ｨ 0205ｨｺｨ ｨｬ ｨｪｨｨ07 ｨｪｨ ｨｮ080609ｨｪ ｨｰ08ｨ ｨｪ09ｨｰ0902ｨｪｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ ﾂ ｨ : ｨ ｨｺ FtsZ, ｨｪｨｨ02 ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ, ｨｬｨｨｨｺ060705ｨ 04ｨｬ ｨｪｨｨ07 ｨｺ0502ｨｰｨｺｨｨ, ｨｮ ﾂｨ 02 ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ ｨｪｨ ｨ 02ｨｬ04ｨｦ ｨｨｨｪ060001ｨ ｨｰｨ 02ｨｨ02ｨｦ, ｨｨ ｨｨｨｰ ｨｰ060006, ｨｺｨ ｨｺ 04ｨ ｨｺ06ｨｪ ﾂｨｨ05ｨｨ09ｨｹ ｨｨｨｺｨ 02ｨｨ ｨｨ ｨ 02ｨｨ07 ｨｪｨｮｨｺ050206ｨｨ01ｨ. 00ｨｨｨｰ06ｨｺｨｨｨｪ0204 ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｺ0502ｨｰｨｺｨｨ ｨｪｨ ﾂｨｨｨｪｨ 02ｨｰ ｨ 08ｨ ｨ ｨｪｨｨ ｨｺｨｨ (090207ｨｰ04) ｨｰｨ 02ｨｨｨｨ ｨｪｨ 0708ｨ ｨｰ0907 ｨｰｨ ｨｺ ｨｪｨ ｨ 02ｨｬ04ｨｬ Z-ｨｺ0605ｨｹ0206ｨｬ ｪ ｨｺ0605ｨｹ0206ｨｬ 0903ｨ ｨｰｨｨ07, ｨｺ06ｨｰ ｨｬｨｨ08ｨｮ02ｨｰ ｨ 05ｨ 09ｨｰｨｨ 09ｨ ｨｦｨｰｨ ｨｪｨｨ07, 06ｨ 04 ﾂｨｪ ｨｨｨｪ02 ｨｺ0502ｨｰｨｺｨｨ. 0105ｨ 09ｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ06ｨｦ ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ 0201ｨｨｨｪｨｨ0202ｨｦ ｨｺ0605ｨｹ02ｨ ｨｰ0907 ｨｪｨｮｨｺ050206ｨｰｨｨ ｨ 06ｨｴｨｨｨｦ ｨ ｨｺ, ｨ ｨｪ04ｨｦ ｨｺ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ ｪ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ. 00 ｨ 0707ｨ 08ｨ ｨｰ ｨｪｨｨ07 ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ09ｨ ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ ｨｨ ｨ ｨｦ ｨｰｨ ｨｺｨｨｨｬ ｨ 0205ｨｺ06ｨｬ ｨｰ0907 FtsZ ｨｹ0206 ｨｨ ｨｨｨｬ0208ｨｨ040609ｨ ｨ 0205ｨｺｨ FtsZ 04ｨ 07ｨｺ0608ｨｨ09ｨ 02ｨｰ0907 ｨｪｨ 02ｨｨｨｰ060705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ02 ｨｺ0502ｨｰｨｺｨｨ 0708ｨｨ 0706ｨｬ06ｨｴｨｨ ｨｬ0600ｨ ｨｰ0205ｨｹｨｪ ｨ 0205ｨｺ0609, ﾂ ｨｪｨ ﾂｨｨｨｪｨ 02ｨｰ 0903ｨｨｨｬｨ ｨｰｨｹ ｨｺ FtsZ 09 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ ﾂｨ 09ｨｰｨｨ 0006ｨｬ ｨｨ ﾂ02ｨｪ ｨｰｨｮｨ ｨｮ05ｨｨｨｪｨｮ, ｨｨ04 ｨｺ06ｨｰ ｨｰ0607ｨｰ ｨｬｨｨｨｺ0806ｨｰ08ｨｮｨ 06 ﾂｨｺｨｨ 05ｨｮｨｺｨ 08ｨｨ06ｨｰ, ｨｨ 09 ﾂｨｨｨｰｨ 02ｨｰ ｨｨ06ｨｪｨｪ04ｨｬ ｨｰ0902ｨｪｨｪｨｨｨｺ06ｨｬ ｨｰｨｮｨ ｨｮ05ｨｨｨｪｨ. 0502ｨｬ02ｨｦ09ｨｰ0906 ｨ 0205ｨｺ0609 FtsZ 03ｨｨ0806ｨｺ06 08ｨ ｨｰ08ｨ ｨｪ02ｨｪ ｨｨ ｨｺｨ 08ｨｨ06ｨｰ ｨｨ 08ｨ 09ｨｰ02ｨｪｨｨｨｦ, ｨｰｨｨ ｨ 0205ｨｺｨｨ ｨｨ ｨｹ04ｨｮ06ｨｰ ｨｪｨｨ ｨ 09ｨｰ ｨ ｨｺ FtsZ ｨｨ (ｨｨ05ｨｨ) ｨｬ ｨｨ ｨｪｨｪ06 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｮ06ｨｰ ｨｮ 0601ｨｪ06ｨｦ ｨｨ04 ｨｰ ｨｮ0707 ｨ ｨｦ, ｨｪ02ｨｺ06ｨｰ ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ ｨｨ ｨｮ ｨｬｨｨｨｰ060106ｨｪ0108ｨｨｨｦ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ09ｨ 05ｨｮｨｺｨ 08ｨｨ06ｨｰ ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ06 09 ｨｪｨ 0409ｨ ｨｪｨｪ ｨｮ ﾂｨ ｨｦ09ｨｰ09ｨｮ06ｨｰ ｨｨｨｪ0402 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ ｨｪｨｨ07, 0708ｨｨ ｨｺ06ｨｰ FtsZ ｨｪ02 ｨｨ ｨｹ04ｨｮ02ｨｰ0907 (Erickson, 2000) ｨ 09ｨｰｨｨ01 ( ｨ 09ｨｰ0609) 0706ｨｬｨｨｨｬ ｨｬ ｨｺｨ 08ｨｨ06ｨｰｨｪ0401 FtsZ ｨｨ ｨｰｨｪ04 02ｨｴ ｨ ｨｰｨｨ07ｨ ｨ 0205ｨｺ ｨｪｨｨ07: 01ｨｨｨｪｨ ｨｬｨｨｨｪ04 ｨｨ ｨ 0205ｨｺｨｨ PD, ｨ ｨｮ ｨｬｨｨｨｰ060106ｨｪ0108ｨｨｨｦ ｪ ｨｨ00ｨｨ ﾂ0209ｨｺｨｨ02 ｨ 0205ｨｺｨｨ MD. 0201ｨｪｨ ｨｺ06 ｨｮ ｨ ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609, 0002ｨｪ06ｨｬ04 ｨｺ06ｨｰ ｨｪ0609ｨｰｨｹ ｨｺ0902ｨｪｨｨ080609ｨ ｨｪ04, 0002ｨｪ04 ｨ 0205ｨｺ ｨｪｨｨ07 ｨｪｨｨ 0601ｨｪ ｨｨ04 05ｨｰｨｨ01 ｨｰ ｨｰｨｨ ｨｪ02 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ ｨｨ ｨｪｨｨ01 ｪ 07ｨ ｨｰ060002ｨｪｨｪｨ 07 ｨｬｨｨｨｺ060705ｨ 04ｨｬｨ Ureaplasma urealyticum (parvum) ｨｹ ｨ 00ｨ 02ｨｬ ｨ ｨ ｨｰ ｨ 0909ｨｬ06ｨｰ0802ｨｪｨｨ02 09ｨｮｨｴ0209ｨｰ09ｨｮ06ｨｴｨｨ ｨｰｨ ｨｪｨｨｨｦ 06 ｨｬ060502ｨｺｨｮ050708ｨｪ0401 ｨｬ0201ｨ ｨｪｨｨ04ｨｬｨ ｨｪｨｨ07 ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ ｨｨ 06ｨ 06ｨ ｨｴ02ｨｪｨｨ02 01ｨ ｨｪｨｪ ｨｰ08ｨｮｨｺｨｰｨｮ0802 ｨｨ 00ｨｮｨｪｨｺ02ｨｨ0701 FtsZ ｨｨ ｨ ｨｬ0600ｨ ｨｰ0205ｨｹｨｪ0401 ｨ 0205ｨｺ0609 ｨｺｨ ｨｺ 0005ｨ 09ｨｪ0401 ｨｨ000806ｨｺ ｨｨｨｰ06ｨｺｨｨｨｪ0204ｨ ｨｪｨｨ07 01ｨ ｨｨｨ ｨｪ ｨｺ0502ｨｰ06 ﾂｨｪ ｨｪｨｨ07 ｨｨ ｨ ｨｪ ｨｮ Escherichia coli ｨｹ03ｨｨｨｪ09ｨｰ ｨｪ0609 ｨｨ ｨ 0205ｨｺ ｨｪｨｨ07 05ｨｰ06ｨｦ ｨ ｨ ｨｺｨｰ0208ｨｨｨｨ ｨ ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪ ｨｨ ｨｨ ｨ ｨｪｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ 09 ｨｮ ｨｪ ｨｰｨ 05ｨｹｨｪ04ｨｬｨｨ ｨｬｨｮｨｰｨ 02ｨｨ07ｨｬｨｨ. 0108ｨｮ0707ｨ ｨｬｨｮｨｰｨ 02ｨｨｨｦ, 0708ｨｨ ｨｴｨｨ01 ｨｺ ｨｬｨｨ080609ｨ ｨｪｨｨ ｨｨｨｪｨｪ ｨｨｨｪｨｮｨｺ050206ｨｨ01ｨｪ0401 ｨｺ0502ｨｰ06 ﾂｨｪ0401 ｨｰ070302ｨｦ, ｨｰ0607ｨｴｨｨ01 ｨｨ04 ｨｺ0502ｨｰ06ｨｺ, ｨｪ02 08ｨ ｨｨ0903ｨｨ ｨｨ ｨｪ ｨｬｨｨ0909ｨｨ09ｨｪ0401 ｨｰ02ｨｬ070208ｨ ｨｰｨｮ08ｨ 01, ｨ 0405ｨ ｨｪｨ 0409ｨ ｨｪｨ fts (filamentous temperature sensitive). 0308ｨｨ 05ｨｰ06ｨｬ ｨ 0506ｨｺｨｨ080609ｨｺｨ ｨｪｨｨ07 ｨｬｨｮｨｰｨ ｨｪｨｰｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｪ ｨｨ0705ｨ ｨｪｨ ｨｨｨｺｨ 02ｨｨｨｨ ｨｨ ｨ 02ｨｨｨｨ (Hirota et al., 1968) ｨｪ06ｨｬ02 E. coli ｨｪ06 ｨｺｨ ｨｺ ｨｬｨｨｨｪｨｨｨｬｨｮｨｬ ｨｪ0609 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｪｨｨ07. 00ｨｪ0600ｨｨ ｨｪ ｨｪｨｨ07 ｨｨ ｨｰｨｨ ｨｨｨｺｨ ｨｪ ｨｨｨｪｨｰ0204ｨ 08ｨ ｨｪ04 ｨｪｨ ｨｬ060906ｨｬ02 ｨｺ06ｨｬ07ｨ ｨｺｨｰｨｪ06 ｨｨ 421

2 ｨｨ03ｨｪ07ｨｺ0609, ｨｪｨｨｨｮ09 06ｨ ｨｲ0201ｨｨｨｪ02ｨｪ04 09 ｨｰｨ ｨｺ ｨｪｨ ｨ 02ｨｬ04ｨｦ ｨｺ05ｨ 09ｨｰ0208 dcw (division and cell wall). 0805ｨ 09ｨｰ0208 ｨｪ02 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨｨ ｨｨ08ｨｮ02ｨｰ0907 ｨｺｨ ｨｺ ｨ 07 ｨｬ060502ｨｺｨｮ05ｨ ｨｬ06ｨｰ ｨｰ06ｨｬ ｨｺ05ｨ 09ｨｰ ﾂｨ 09ｨｰ ｨｺｨ 05ｨｨ040609ｨ ｨｪ04 09ｨｪｨｮｨｰ08ｨｨ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰ02ｨｦ ｨ 05ｨｨ ｨ ｨｴｨｨ01 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ ｨｪ0609, ｨｪ06 ｨｪ ｨｨ04 ｨｪｨｨ ｨｺｨ 04ｨ ｨｪｨ ｨ ｨｪ0609ｨｰｨｹ ｨｨｨｪｨｨ02ｨｨｨｨ080609ｨ ｨｰｨｹ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ ｨｬ07 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｪｨｨ ｨｪ ftsz ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨｨ ｨｨ08ｨｮ02ｨｰ ｨ ｨｬ06ｨｰ , 08ｨ ｨｪｨｪ ｨ ｨｪ0609 ddlb, ftsq ｨｨ ftsa ｨｺ05ｨ 09ｨｰ0208ｨ dcw (Vicente, Errington, 1996) ｨｰｨｪ06, 05ｨｰ06 ｨｪ0206ｨ ｨｨｨｬ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ07 ｨｪｨ ｨｪ0609ｨｰｨｨ 09ｨｨｨｪｨｰ0204ｨ ｨ 0205ｨｺｨ FtsZ. 00 ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｬ 02ｨｨｨｺ0502 ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ04ｨｦ ｨｮ ｨｪｨｹ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ ftsz ｨｰ0902ｨｰ09ｨｰ09ｨｮ02ｨｰ ｨｪｨ ﾂｨ 05ｨｮ 06ｨ 08ｨ ｨ ｨｪｨｨ ｨｰ ｨｺ05ｨ 09ｨｰ dcw Bacillus subtilis ｨｪ ｨｪ0609, ｨｪ06 ｨｰ0605ｨｹｨｺ ｨｨ04 ｨｪｨｨ01 ｨｨｨｬ0202ｨｰ ﾂ0209ｨｨ01ｨｪｨ 07 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪｨ ｨｬ ｨｨ ｨ ｨｪ06ｨｬ ｨｺ05ｨ 09ｨｰ E. coli ｨｪ ｨｰ ｨｺ05ｨ 09ｨｰ0208ｨ ｨｰ0605ｨｹｨｺ06 ftsz ｨｰｨ ｨｪ ｨ ｨｴ02ｨｬ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ ｨ ｨｪｨ 05ｨｨ04ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ ｨｪｨ 09ｨｰ0607ｨｴ02ｨｬｨｮ ｨｬ02ｨｪｨｨ 0002ｨｪ06ｨｬｨ ｨｺｨ 08ｨｨ06ｨｰ ｨｨ, ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, ｨｰ0907 ｨｪｨ ｨｨｨ ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪ04ｨｬ ｨｨ ｨ 0205ｨｺ ｨｪｨｨ07 ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ. 0809ｨｰ ｨｬ06ｨｰ ｨｨ02 ｨｪ0201ｨ 09ｨｪ ｨｬ0603ｨｪ04ｨｦ ｨｰｨ ｨｪ0609 ｨｰ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 00ｨｬｨｨｨｪｨｨｨｬｨ 05ｨｹｨｪ06ｨｦ ｨｺ0502ｨｰｨｺｨｨ03, ｨｨ ｨｪ0609, ｨｺ0601ｨｨ08ｨｮ06ｨｴｨｨ01 ｨ 0205ｨｺｨｨ ｨｪｨｨ07, 09ｨｺ0506 ﾂｨｨ05ｨｨ 09 ｨｪ ｨｰ0605ｨｹｨｺ06 ftsz (Gil et al., 2004) ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ06 FtsZ ｪ ｨｦ ｨ ｨｺ, ｨｺ06ｨｰ060804ｨｦ ｨｰ0907 ｨｪｨ ｨｬ0209ｨｰ02 ｨ ｨｮ01ｨｮｨｴ ｨｬｨ ｨｺ0806ｨｬ060502ｨｺｨｮ050708ｨｪ ｨｺ06ｨｬ070502ｨｺ09ｨ (Bi, Lutkenhaus, 1991), ｨｪｨ 0409ｨ ｨｪｨｪ ｨｨ09ｨｨ0906ｨｬ06ｨｦ (Nanninga, 2001). 01ｨ 0609ｨｪ0609ｨ ｨｪｨｨｨｨ 0802ｨｪｨｰ0002ｨｪ0609ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ ｨ ｨｪｨ 05ｨｨ04ｨ ｨｪ06 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ ｨｰ0906 ｨｰ0802ｨｰｨｨ ﾂｨｪ ｨｰ08ｨｮｨｺｨｰｨｮ08 FtsZ ｨｨ ｨｬ06ｨｪ06ｨｬ ｨ /09-ｨｰｨｮｨ ｨｮ05ｨｨｨｪｨ, ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ 0908ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ ｨ ｨ ｨｮ ｨｬ ｨｨ ｨｨ ﾂｨｪ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰ02ｨｦ (L02we, Amos, 1998) ｨｺｨ 04ｨ ｨｪｨｪｨ 07 09ｨｰ0608ｨｨ ﾂｨｪｨ 07 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨ ｨ 0205ｨｺｨ FtsZ ｨｨ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ0609 ｨｨｨｬ0202ｨｰ ｨｮ01ｨｨ09ｨｨｨｰ0205ｨｹｨｪ ｨｰ0906 ｨｪｨ ｨｮ ﾂｨ 09ｨｰｨｺｨ 01, 08ｨ ｨｪｨｪ ｨ ｨｦ06ｨｪ ｨｰ05ｨｨ, ｨ 0600ｨ ｨｰ06ｨｦ 0005ｨｨ02ｨｨｨｪ06ｨｬ. 08ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ ｨｰ0906 ｨｰｨｮｨ ｨｮ05ｨｨｨｪ0609 ｨｨ FtsZ ｨｰ ｨ ｨｪ0609ｨｰｨｨ ｨｺ ｨ ｨｪｨｨ06 ｨｨ 00ｨｨ ｨｨ04ｨｮ , ｨ ｨｰｨ ｨｺ ｨ ｨｪ0609ｨｰｨｨ 06ｨ 08ｨ ｨ ｨｰｨｹ 05ｨｨｨｪ02ｨｦｨｪ0402 ｨｪ020902ｨｰ0907ｨｴｨｨ ｨｨｨｬ (070806ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ04) in vitro. 0201ｨｪｨ ｨｺ06 09 ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰ0701 ｨｺｨ ｨｺ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ0609, ｨｰｨ ｨｺ ｨｨ ｨ 0205ｨｺｨ FtsZ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｮ06ｨｰ ｨｰ08ｨｨ ｨｮ ﾂｨ 09ｨｰｨｺｨ, 06ｨ 08ｨ 04ｨｮ06ｨｴｨｨ ｨ 06ｨｴｨｨ02 ｨｬ06ｨｰｨｨ G-ｨ 0205ｨｺ0609 ｪ ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ0401 ｨ 0205ｨｺ0609, 06ｨ 05ｨ 01ｨ 06ｨｴｨｨ ｨ 06ｨｴ02ｨｦ ｨｨ ｨ 04ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 ｨｨ ｨｪ0706ｨｴｨｨ01 09 ｨｺ0502ｨｰｨｺ ｨｮ0507ｨｰ0608ｨｪ ｨｮｨｪｨｺ02ｨｨｨｨ. 00 ｨｰ ｨｬ07 ｨ ｨｪｨ 05ｨｨ04 ｨｰ080201ｨｬ0208ｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ ｨｰｨｨ01 ｨ 0205ｨｺ ｨｨ05 06ｨ ｨｪｨ 08ｨｮ03ｨｨｨｰｨｹ ｨｺ ｨｰ0906 ｨｬ020301ｨｮ ｨ 06ｨｴｨｨｨｬｨｨ 0106ｨｬ02ｨｪｨ ｨｬｨｨ G-ｨ 0205ｨｺ0609, ｨ 0205ｨｺｨ FtsZ ｨｨ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ0609 (Erickson, 1998). 08 ｨｪｨ ﾂｨ 05ｨｮ ｨｪｨｨ07 ｨｺ0502ｨｰｨｺｨｨ ｨ ｨｺ FtsZ ｨｰｨ ｨｰ 0609ｨｪ0609ｨｮ 09ｨｰ08ｨｮｨｺｨｰｨｮ0804, ｨｨ ｨｰｨｪ06ｨｦ ｨｺｨ ｨｺ Z-ｨｺ0605ｨｹ ｨｨ06ｨｪｨｪ06ｨｬ 0705ｨ ｨｪ02 00ｨｨ05ｨ ｨｬ02ｨｪｨｰ04 Z-ｨｺ0605ｨｹ02ｨ 09 ﾂｨｨｨｰｨ 06ｨｰ ｨｰ0902ｨｪｨｪｨｨｨｺｨ ｨｬｨｨ ｨｬｨｨｨｺ0806ｨｰ08ｨｮｨ 06 ﾂ02ｨｺ 05ｨｮｨｺｨ 08ｨｨ06ｨｰ (Erickson, Stoffler, 1996). 07 ﾂｨ 09ｨｰｨｨ02 ｨ 0205ｨｺｨ, ｨｺ0601ｨｨ08ｨｮ02ｨｬ ｨｪ06ｨｬ ftsz, 09 ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｬ ｨｪｨｨｨｨ ｨ ｨｪ06 ｨｮ E. coli (Lutkenhaus et al., 1980). FtsZ E. coli ｪMg ｨ 09ｨｨ09ｨｨｨｬｨ ｨ 04ｨ. 00 ｨｪ ｨｴｨｨ ｨｺ0502ｨｰｨｺｨ 01 ｨｪｨ 09 ﾂｨｨｨｰ0409ｨ 02ｨｰ ｨｰ ｨｰ0409. ｨｬ060502ｨｺｨｮ05 FtsZ, ｨｺ06ｨｰ ｨ ｨｪ ｨｦ 02ｨｨｨｰ060705ｨ 04ｨｬ ｨｪｨ ｨｺ06 ｨｺ ｨｬ06ｨｬ02ｨｪｨｰｨｮ ｨｨｨｪｨｨ02ｨｨｨ 02ｨｨｨｨ ｨ ｨｪｨｨ07 06ｨｪｨｨ ｨｬｨｨ08ｨｮ06ｨｰ Z-ｨｺ0605ｨｹ ｨｨｨｪ02 ｨｺ0502ｨｰｨｺｨｨ. 0308ｨｨ ｨｮ06ｨｴ02ｨｬ ｨ 09ｨｰｨ ｨｪｨｨｨｨ ｨｰｨｨ ｨｨｨｺｨ ｨｪ060906ｨｦ 09ｨｰ02ｨｪｨｺｨｨ 09ｨｪｨｮｨｰ08ｨｹ ｨｺ0502ｨｰｨｺｨｨ 01ｨｨｨ ｨｬ02ｨｰ08 ｨｺ0605ｨｹ02ｨ ｨｰ020702ｨｪｨｪ06 ｨｮｨｬ02ｨｪｨｹ03ｨ 02ｨｰ0907, ｨｨ ｨｺ ｨｬ06ｨｬ02ｨｪｨｰｨｮ 06ｨｺ06ｨｪ- ﾂｨ ｨｪｨｨ07 09ｨ 0608ｨｺｨｨ ｨｺｨｨ (090207ｨｰ04) ｨｺ0605ｨｹ0206 ｨｨ09 ﾂ0204ｨ 02ｨｰ (Bi, Lutkenhaus, 1991) ｨ ｨｺ FtsZ ｨ ｨｪ ｨｮ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ09ｨ 0609ｨｪ0609ｨｪ ｨｮ0707 ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ, 09 05ｨｮ08ｨｨｨ ｨ 05ｨｹｨｪ06ｨｦ 0902ｨｰ09ｨｨ Archaea, ｨ ｨｰｨ ｨｺ ｨ ｨｪ020505ｨ 01 08ｨ 09ｨｰ02ｨｪｨｨｨｦ, ｨｨｨｬ0206ｨｴｨｨ01 05ｨｪ010609ｨｨｨｬｨ ｨｨ06ｨｪｨｰｨｪ ｨｨ ｨｪｨｨ02, ｪ ｨ 09ｨｰｨ 01 ｨｨ ｨｪ02ｨｺ06ｨｰ ｨｬｨｨｨｰ060106ｨｪ0108ｨｨ ｨｺ ｨｪｨ 09ｨｰ0607ｨｴ02ｨｬｨｮ ｨｬ02ｨｪｨｨ ｨｪ ｨｪ0608ｨ 04ｨｬ0208ｨｪ ｨｬ FtsZ ｨｨ ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ, ｨ ｨｦ ｨｨ 05ｨｪ010609ｨｨｨｬｨ ｨｨ06ｨｪｨｰｨｪ ｨ ｨｪ ｨｮｨｺｨ 08ｨｨ06ｨｰ ｨｬ02 ｨｰ060006, ｨｨ ｨｰｨｪ04 FtsZ ｨ ｨｪ0402 ｨ 0205ｨｺｨｨ, ｨｪ FtsZ ｨｰ08ｨｮｨｺｨｰｨｮ0802, ｨｪ06 ｨｪ ｨ ｨｪ ｨ ｨｰｨｹ ｨｨ 00ｨｨ ｨｨ040609ｨ ｨｰｨｹ (Vaughan et al., 2004). 05ｨｰ080602ｨｪｨｨ02 ｨｬ060502ｨｺｨｮ0504 FtsZ 0808ｨｨ09ｨｰｨ ｨ 00ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨ ｨｪｨ 05ｨｨ04 09ｨｰ08ｨｮｨｺｨｰｨｮ0804 FtsZ ｨ ｨｪ02ｨｪ ｨ 0205ｨｺｨ ｨｨ04 ｨｰ0208ｨｬ0600ｨｨ05ｨｹｨｪ06ｨｦ ｨ ｨ ｨｺｨｰ0208ｨｨｨｨ Thermotoga maritima, 0708ｨｨ ﾂ02ｨｬ ｨ 0405ｨｨ ｨｪ04 ﾂ02ｨｰ ｨｬ02ｨｪｨ (L02we, Amos, 1998). 0508ｨ 09ｨｪ02ｨｪｨｨ02 ｨｨ ｨｰｨｪ0401 ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰ02ｨｦ 0006ｨｬ FtsZ ｨｨ0506 ｨｮ09ｨｰｨ ｨｪ0609ｨｨｨｰｨｹ, ﾂｨｰ ｨ ｨｪｨ 07 ﾂ02ｨｰ ｨｬ02ｨｪｨｪｨ 07 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪｨ FtsZ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ09ｨ ｨｺｨ 08ｨｨ06ｨｰ: 09ｨ 08ｨｨｨ ｨ 0205ｨｹｨｪ04ｨｦ N-ｨｺ06ｨｪ ｨｦ ｨｬ02ｨｪｨｰ, ｨｺ06ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪｨ 07 ｨｺ ｨ 07 06ｨ 05ｨ 09ｨｰｨｹ, 09ｨ 08ｨｨｨ ｨ 0205ｨｹｨｪ04ｨｦ ｨｦ ｨｨ ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪ04ｨｦ C-ｨｺ06ｨｪ ｨｦ ｨｰｨｨ01 (Vaughan et al., 2004) ｨ 0205ｨｺ0609 FtsZ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ06 ｨｪｨ 05ｨｨ ﾂｨｨ02 ｨｪｨ N-ｨｺ06ｨｪ0202 ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪ06ｨｦ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ, ｨｺ06ｨｰ060806ｨｦ ｨｪ02ｨｰ ｨｮ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ ｨ ｨｪｨ 08ｨｮ0302ｨｪ06, ﾂｨｰ ｨｨ ｨ 0205ｨｺ0609 FtsZ ｨｨｨｬ0206ｨｰ ｨｺｨ ｨｺ ｨｬｨｨｨｪｨｨｨｬｨｮｨｬ 0707ｨｰｨｹ ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰ, 08ｨ ｨｪｨｪ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ ｨｺ ｨｬ02ｨｪｨ. 0609ｨｺ0506 ﾂ02ｨｪｨｨ07ｨｬｨｨ ｨｰ ｨｨ03ｨｹ 0902ｨｬｨｹ 0006ｨｬ ｨｨ ｨｬ02ｨｦ09ｨｰ09ｨ FtsZ3 ｨ ｨｦ. 00 N-ｨｺ06ｨｪ ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ FtsZ1 Methanococcus jannaschii ｨｬｨｨ08ｨｮ06ｨｰ0907 ｨ -0907ｨｨ08ｨ 05ｨｹ ｨｨ 0702ｨｰ0507, ｨｺ06ｨｰ ｨ 06ｨｰ0907 ｨｨ ｨ ｨｬ060502ｨｺｨｮ0504 (L02we, Amos, 1998). N-ｨｺ06ｨｪ ｨｦ ｨｬ02ｨｪｨｰ ｨｪ ｨｰ0907 ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪ04ｨｬ ｨｪｨｨ ｨｨｨｪ02, ｨｪｨｨ 0706 ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪ06ｨｦ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｦ 0106ｨｬ02ｨｪ ｨｰ070302ｨｪｨｪ0609ｨｰｨｹ ｨｨｨｬ0208ｨｪ ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰ ｨｨｨｰ ｨｰｨ ｨｰｨｺｨｨ, ｨｰ0802ｨ ｨｮ02ｨｬ ｨ ｨｪｨｨ07 ｨｨ 00ｨｨ ｨｨ04ｨ (Erickson, 1995). 01ｨ ﾂｨ ｨｬ02ｨｪｨ 08ｨ ｨｪｨ 06ｨｰ 0706 ｨｪｨ 05ｨｨ ﾂｨｨ06 09 ｨｬ060502ｨｺｨｮ0502 FtsZ ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪ ｨｨ ｨｦ02ｨｨｨｪｨ (05ｨｨ03ｨｹ ｨｮ ﾂｨ ｨ ｨｬ02ｨｪ ｨｨ ｨｬ ). 02ｨｺ06ｨｪ ﾂｨ ｨｪｨｨ02 06ｨ 05ｨ 09ｨｰｨｨ ｨｺ ｨｬ02ｨｪｨ ｨｬ060502ｨｺｨｮ ｨｨ010601ｨｨｨｰ0907 ｨｪｨ ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪｨｮ06 ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪｨｮ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｹ LVITG (Vaughan et al., 2004) ｨｰｨｨ ﾂｨｪｨ 07 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨ ｨｺ ｨｬ02ｨｪｨ 09 ｨ 0205ｨｺｨ 01 FtsZ 0708ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨｨ ｨ 01ｨ 02ｨｰ ｨｮｨｬ07 06ｨ 05ｨ 09ｨｰ07ｨｬｨｨ ｨｰ0802ｨｰｨｨ ﾂｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ0804 ｨ /09-ｨｰｨｮｨ ｨｮ05ｨｨｨｪ ｨｦ 0106ｨｬ02ｨｪ ｨｬ060502ｨｺｨｮ0504 FtsZ ｨｰ06ｨｨｨｰ ｨｨ ｨｮ01 ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ ｨ ﾂｨｨ09ｨ 06ｨｴｨｨ N-ｨｺ06ｨｪ ｨｨ C-ｨｺ06ｨｪ ｨｬ02ｨｪｨｰ0609, 06ｨ 08ｨ 04ｨｮ06ｨｴｨｨ01 09ｨｮｨ 0106ｨｬ02ｨｪ04 Nt ｨｨ Ct ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06 (Oliva et al., 2004). 05ｨｮｨ 0106ｨｬ02ｨｪ Nt ｨｨｨｰ 06ｨ 05ｨ 09ｨｰｨｹ, 06ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪｨｮ06 04ｨ ｨ ｨｪｨｨ02 ｨｨ 00ｨｨ ｨｨ ｨｰ06ｨｰ 09ｨｮｨ 0106ｨｬ02ｨｪ ｨ 02ｨｪ 0708ｨｨ ｨｨｨｪ07ｨｰｨｹ ｨｪｨｨ03ｨｪ0606 ﾂｨ 09ｨｰｨｹ ｨｪ ｨｬ06ｨｪ06ｨｬ0208ｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ02. 05ｨｮｨ 0106ｨｬ02ｨｪ Ct ｨ 02ｨｰ ｨｪ0606 ﾂｨ 09ｨｰｨｹ ｨｪ ｨｬ06ｨｪ06ｨｬ0208ｨ ｨ 07 06ｨ 05ｨ 09ｨｰｨｹ ｨ 0205ｨｺ0609 FtsZ ｨｨｨｰ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｹ, 0006ｨｬ ｨｨ ﾂｨｪｨｮ ｨｺ06ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪ06ｨｬｨｮ ｨｬ06ｨｰｨｨ09ｨｮ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ0609: ｨｰ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ ｨｬ06ｨｰｨｨ09ｨ ｨ 0205ｨｺｨ 01 FtsZ ｨｮ09ｨｰｨ ｨｪ ｨｪ ｨｺ06ｨｪ0902ｨｪ09ｨｮ09 GGGTGTG (Erickson, 1995). 02ｨ ｨｪｨ 08ｨｮ0302ｨｪ06 ｨｨｨｪｨｰ ｨｪ ｨ ｨｨ0601ｨｨｨｬｨｨ ﾂ0209ｨｺ06ｨｦ ｨｰ06 ﾂｨｺｨｨ ｨｪｨｨ ｨｦ09ｨｰ0906 ｨｬ060502ｨｺｨｮ0504 FtsZ: ｨｰ06 ﾂ02 ﾂｨｪｨ 07 ｨｬｨｮｨｰｨ 02ｨｨ07, ｨｰ09ｨｨ02ｨｬ ｨｺ06ｨｰ060806ｨｦ ｨｰ ｨ ｨｬ02ｨｪｨ 0609ｨｰｨ ｨｰｨｺｨ Gly ( ｨｦ 0005ｨｨ02ｨｨｨｪ ｨｺ06ｨｪ0902ｨｪ09ｨｮ09ｨ GGGTGTG) ｨｪｨ Ser ｨｦ ｨｨ02ｨｨｨｨ 09 ｨ 0205ｨｺ02 FtsZ E. coli, 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｰ06ｨｬｨｮ, ﾂｨｰ06 ｨｬｨｮｨｰｨ ｨｪｨｰｨｪ04ｨｦ ｨ ｨｺ 09ｨｬ0209ｨｰ ｨ 04ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｰ Mg ｨ 09ｨｨ09ｨｨｨｬｨｮ ｨ 04ｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ in vitro (RayChaudhuri, Park. 1994) ｨｺ FtsZ 06ｨ 05ｨ 01ｨ 02ｨｰ 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ04ｨｬ ｨｰ0906ｨｬ ｨｮ00ｨｨｨｬｨｨ ｨ 04ｨ ｨｬｨｨ ｪ ｨ 0102ｨｪｨｨ05ｨ ｨｰｨｺｨｨｨｪｨ 0406ｨｦ, ｨｬｨｨ0604ｨｨｨｪｨ ｨｬｨｨ ｨｨ F ｨ 04ｨ ｨｬｨｨ. 0308ｨｨ 05ｨｰ06ｨｬ 04ｨ ｨｬ02ｨｪｨ ｨｪ06ｨｦ ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰ ｨ 08ｨ ｨｺｨｰ0208ｨｪ06ｨｬ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ060906ｨｬ ｨｬ06ｨｰｨｨ ｨ ｨｴｨ 02ｨｰ FtsZ ｨｨ ｨ ｨ 04ｨｮ.

3 ｨｺ FtsZ ｨｨ 02ｨｨｨｰ06ｨｺｨｨｨｪ0204 ｨｮ ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ ｨｦ ｨｹｨｬｨ 09ｨ 08ｨｨｨ ｨ ｨｪ ｨｨｨｪ02 (06ｨｰ ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰ). 06ｨ ｨｺ, ｨｮ FtsZ1 M. jannaschii 05ｨｰ06ｨｰ ｨｮ ﾂｨ 09ｨｰ06ｨｺ ｨｰ06ｨｨｨｰ ｨｨ04 16 ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰ, ｨｬｨｨ08ｨｮ06ｨｴｨｨ ｨ 09-09ｨｰ0802ｨｪ01ｨ, 08ｨ ｨｪｨｪ ｨｰ0502ｨｦ ｨｨ04 9 ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰ, ｨｪ02 06ｨ 08ｨ 04ｨｮ06ｨｴｨｨ01 ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ0804 (L02we, Amos, 1998). 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ ｨｦ ｨｪ ｨｰ0907 ｨｪ0206ｨ ｨｨｨｬ04ｨｬ ｨ 08ｨ ｨ ｨｪｨｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609 FtsZ. C-ｨｺ06ｨｪ ｨｦ ｨｰｨｨ01 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ 05ｨｨ03ｨｹ ｨｬ ｨ 01 FtsZ ｨｨ ｨｨ ｨ ｨｪｨｪ ｨｰ06ｨｰ ｨｮ ﾂｨ 09ｨｰ06ｨｺ ｨｬ060502ｨｺｨｮ0504 ｨｪ02 ｨｪｨｮ0302ｨｪ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ, ｨｪ06 ｨｪ0206ｨ ｨｨｨｬ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ ｨｮｨｬ ｨｮ00ｨｨｨｬｨｨ ｨ 0205ｨｺｨ ｨｬｨｨ ｪ FtsA ｨｨ ZipA, ｨｺ06ｨｰ ﾂ ｨｹ 0802ｨ 00ｨｨ08ｨｮ06ｨｰ 09 ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ06ｨｦ (Ma, Margolin, 1999). 0502ｨｬ02ｨｦ09ｨｰ0906 ｨ 0205ｨｺ0609 FtsZ ｨｨ FtsZ ｨ ｨｪ0402 ｨ 0205ｨｺｨｨ ｨ ｨｺｨ 08ｨｨ06ｨｰ ｨｪ0609ｨｰｨｹ ｨｺ0902ｨｪｨｨ080609ｨ ｨｪｨｪ04ｨｬｨｨ 0002ｨｪ06ｨｬｨ ｨｬｨｨ 0006ｨｬ ｨｨ FtsZ ｨｪ02 ｨ 0405ｨｨ 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ ｨｬ0603ｨｪ ｨ 06ｨ ｨｲ0709ｨｪ02ｨｪｨｨ07 05ｨｰ06ｨｬｨｮ 00ｨ ｨｺｨｰｨｮ: 1) ｨｰｨ ｨｺｨｨ ｨ ｨｪｨｨ04ｨｬ ｨｰ ｨ ｨｴ02 ｨ 0204 ｨｮ ﾂｨ 09ｨｰｨｨ07 FtsZ; 2) ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪｨ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｹ FtsZ ｨ ｨｪ0401 ｨ 0205ｨｺ0609, ｨ ｨｪ ｨｮｨｪｨｺ02ｨｨ06, ｨｨｨｨ ｨｨ04ｨｬ02ｨｪｨｨ05ｨ 09ｨｹ 0106 ｨｪ02ｨｮ04ｨｪｨ 09ｨ 02ｨｬ0609ｨｰｨｨ ｨｰ06ｨｬｨｮ ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ06ｨｦ ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ06- ﾂ02ｨｺ ｨｪｨｨ07 ｨｪｨ ｨｨｨ ｨｨｨｪｨｰ ｨｪ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 0006ｨｬ ｨ 0205ｨｺｨ FtsZ, ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ06 08ｨ ｨｨ ｨｨｨｨ ｨｨ ｨｪｨｨ01 ｪ FtsZ ｨｬｨｨｨｺ060705ｨ 04ｨｬ Mycoplasma pneumoniae ｨｨ M. genitalium, FtsZ ｨｰ0206ｨ ｨ ｨｺｨｰ0208ｨｨｨｨ Colwellia psychrerythraea, FtsZ ｨｪ ｨｨｨ ｨ Dictyostelium discoideum, ｨ ｨｰｨ ｨｺ ｨｨ ｨｰｨｪ0402 ｨ 0205ｨｺｨｨ FtsZ3 ｨ ｨｦ ｨｰｨｨ07ｨ Euryarchaeota ｨｰｨｨ ｨ 0205ｨｺｨｨ (04ｨ ｨｨ09ｨｺ0506 ﾂ02ｨｪｨｨ02ｨｬ FtsZ ｨｬｨｨｨｺ060705ｨ 04ｨｬ) 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ04 ｨｮ ｨ ｨｪｨｨ04ｨｬ0609, 06ｨ 05ｨ 01ｨ 06ｨｴｨｨ01 ｨｪ0209ｨｺ0605ｨｹｨｺｨｨｨｬｨｨ ｨｺ0607ｨｨ07ｨｬｨｨ ftsz ｨｪｨ 0002ｨｪ06ｨｬ, ｨｰ06ｨｬｨｮ ｨ ｨｪ ｨｮ ﾂｨ ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ ｨｪｨ ｨｨ04 ｨｺ0607ｨｨｨｦ ｨｺ0601ｨｨ08ｨｮ02ｨｰ ｨ ｨｺ FtsZ, ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｴｨｨｨｦ ｨｪｨｨｨｨ, ｨ 0108ｨｮ00ｨ 07, 06ｨ 08ｨ ｨ 0903ｨ ｨｮ05ｨｹｨｰｨ ｨｰ ｨｮ0705ｨｨｨｺｨ 02ｨｨｨｨ, ｨｬ060302ｨｰ ｨｺ0601ｨｨ080609ｨ ｨｰｨｹ FtsZ ｨ ｨｪ04ｨｦ ｨ ｨｺ, ｨｪ0706ｨｴｨｨｨｦ ｨｨｨｪｨｮ06 00ｨｮｨｪｨｺ02ｨｨ06, ｨｪ ｨ ｨｪｨｪｨｮ ｨｨｨｰ06ｨｺｨｨｨｪ020406ｨｬ (Vaughan et al., 2004) ｨｨ FtsZ ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ, 0708ｨｨｨｪｨ ｨ ｨｴｨｨ01 ｨｺ ｨｺ05ｨ 0909ｨｮ Mollicutes (ｨｬｨｨｨｺ060705ｨ 04ｨｬ04), ｨ 0405ｨｨ ｨｪ ｨ ｨｪｨ ｨｨｨ ｨｨ05ｨｹｨｪ06 01ｨｨ ｨｨ080609ｨ 0903ｨｨ ｨｬ ｨ ｨ 0205ｨｺｨ FtsZ. 08ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨ 0205ｨｺ0609 FtsZ M. pneumoniae ｨｨ M. genitalium ｨ 01ｨ 06ｨｰ ｨｰ0605ｨｹｨｺ06 ｨｪｨ 53 %, ｨｪ ｨｮ00ｨｨｨｬｨｨ FtsZ ｨｬｨｨｨｺ060705ｨ 04ｨｬ, 09ｨｺ0506 ﾂｨ 07 FtsZ M. pulmonis, M. penetrans ｨｨ M. hominis, ｨｰ ｨｰｨ ｨｰ 17 ｨｨ 21 % ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨ ｨｪｨ 05ｨｨ ｨｨ ｨｨｨｰｨｹ 06 ﾂ02ｨｪｨｹ ｨｬｨ 0502ｨｪｨｹｨｺ ｨｰ0906 ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪ ｨｰｨ 09ｨ FtsZ M. pneumoniae ｨｨ M. genitalium ｨｰｨ 05ｨｹｨｪ04ｨｬｨｨ 0006ｨｬ ｨ ｨｬｨｨ FtsZ ｨｪｨ ﾂｨｨｨｪｨ ｨ 05ｨ 09ｨｰｨｨ, 08ｨ ｨｪｨｪ06ｨｦ 0908ｨ 04ｨｮ 04ｨ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04ｨｬ ｨ 06ｨｴｨｨｨｬ ｨｬ06ｨｰｨｨ0906ｨｬ (Erickson, 1995; ｨｪｨｨｨｮ09 ｨｨ 0108., 2002). 02ｨ 05ｨ 09ｨｰｨｹ C-ｨｺ06ｨｪ02ｨ ｨｺ ｨｬ02ｨｪｨ 0905ｨ ｨ 06ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪｨ, ﾂｨｰ ｨｨ090601ｨｨｨｰ ｨｺ 04ｨ ｨｰ08ｨｮ01ｨｪ02ｨｪｨｨ07ｨｬ 0708ｨｨ ｨｰｨｺ02 08ｨ ｨ ｨｪｨｨ ﾂｨｨｨｰｨｹ ﾂ02ｨｰ ｨｬ02ｨｪｨ, 0607ｨｨ09ｨ ｨｪｨｪ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ09ｨ 0006ｨｬ FtsZ. 0106ｨｬ ｨｨ FtsZ ｨｨ04 08ｨ 04ｨｪ ｨ ｨｪｨｨ04ｨｬ0609 ﾂｨ 09ｨｰ06 ｨｪ ｨ ｨｪ04 04ｨ ｨｬ02ｨｴｨ ｨｰｨｹ 00ｨｮｨｪｨｺ02ｨｨ ｨ 09ｨｰ0902ｨｪｨｪ FtsZ 09 ｨｺ0502ｨｰｨｺｨ 01 E. coli, ﾂｨｰ06 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨ ｨｪ ｨ 0405ｨｨ ﾂｨｨ07ｨｬｨｨ 09 09ｨｰ08ｨｮｨｺｨｰｨｮ0802 C-ｨｺ06ｨｪ ｨｰｨｨ01ｨ (Ma, Margolin, 1999). 0201ｨｪｨ ｨｺ06 ｨｪｨ ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ01 03ｨｰｨ ｨｬｨｬｨ 01 E. coli, ｨｰ08ｨ ｨｪ090006ｨｬｨｨ080609ｨ ｨｪｨｪ ｨｺ06ｨｬｨ ｨｨｨｪｨ ｨｪｨｰｨｪ04ｨｬｨｨ 0705ｨ 04ｨｬｨｨ01ｨ ｨｬｨｨ ｨｪ06ｨｬ ftsz M. hominis, ｨ 0405ｨ ｨｬ06ｨｪ09ｨｰ08ｨｨ080609ｨ ｨｪｨ ｨｬ0603ｨｪ0609ｨｰｨｹ 05ｨｺ ｨｨｨｨ ｨｬｨｨｨｺ060705ｨ 04ｨｬ02ｨｪｨｪ ｨｪｨ ｨｨ 0706ｨｺｨ 04ｨ ｨｪ ｨｺｨｰ ｨｺ06ｨｬ070502ｨｬ02ｨｪｨｰｨ 02ｨｨｨｨ ｨｬ020301ｨｮ 0906ｨ 09ｨｰ0902ｨｪｨｪ04ｨｬ ｨ 0205ｨｺ06ｨｬ FtsZ E. coli ｨｨ FtsZ M. hominis, 05ｨｺ ｨｨ08ｨｮ02ｨｬ04ｨｬ ｨｺ06ｨｬｨ ｨｨｨｪｨ ｨｪｨｰｨｪ06ｨｦ 0705ｨ 04ｨｬｨｨ0104 (Momynaliev et al., 2002; 0006ｨｬ04ｨｪｨ 05ｨｨ0209 ｨｨ 0108., 2003). 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ ｨ 0405ｨｨ ﾂｨｨ07 09 ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪ06ｨｦ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ, 09 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｬ 09ｨｬ ｨｰｨｨ ｨ 0205ｨｺｨｨ 06ｨｺｨ ｨ 06ｨｰ ｨ ｨｨｨｬ0604ｨ ｨｬ02ｨｪ0702ｨｬ04ｨｬｨｨ. 0306ｨｬｨｨｨｬ06 ｨｨ ｨｰｨｪ ｨｪｨ 09ｨｰ0607ｨｴ ｨｬ ｨｬ FtsZ ｨｪ06 02ｨｴ ｨｰｨｺ0804ｨｰ ｨ ｨｬ06ｨｺ 09 ﾂｨｨｨｰ0409ｨ ｨｪｨｨ07, ｨ 00ｨ 02ｨｬ ｨｮｨｺｨｰ04 ｨｺ06ｨｰ ｨ 0604ｨｪｨ ﾂ02ｨｪ04 ｨｺｨ ｨｺ FtsZ ｨ ｨｪ0402 ｨ 0205ｨｺｨｨ. 06ｨｰｨｨ ｨ 0205ｨｺｨｨ ｨｬ0603ｨｪ06 ｨｮ ｨｪ06 08ｨ ｨｨｨｰｨｹ ｨｪｨ 0109ｨ ｨｰｨｨ07ｨ ｨ 0205ｨｺ ｨｰｨｨ07ｨ 01ｨ 08ｨ ｨｺｨｰ020802ｨｪ ｨｪｨｨ04ｨｺｨｨｨｦ ｨｮ ｨｪｨｹ ｨ ｨｨ07 ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰ02ｨｦ ｨ 0205ｨｺｨ ｨｬ FtsZ ｨｺｨｨ 09ｨｰ ｨｰｨｨ07ｨ ｨｹｨｬｨ ｨｪ ｨｨ ﾂｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ0906ｨｬ 0006ｨｬ FtsZ, ｨｪ ｨｨ 05ｨｰ06ｨｬ ｨｨｨｬ0206ｨｰ 04ｨ ｨｬ02ｨｪ ｨ 05ｨ 09ｨｰｨｨ ｨｺ ｨｬ02ｨｪｨ ｨｪ02 06ｨ ｨｲ0201ｨｨｨｪ0706ｨｰ 09 06ｨｰ010205ｨｹｨｪ ｨｬ02ｨｦ09ｨｰ0906, ｨｪ ｨｪｨｨ ｨｪ ｨ ｨｪ ｨ ｨｰｨｹ ｨｨ 00ｨｨ ｨｨ040609ｨ ｨｰｨｹ (Vaughan et al., 2004). 02ｨ ｨｪｨ 08ｨｮ0302ｨｪｨ 06ｨｰｨｺ0804ｨｰｨ 07 08ｨ ｨｬｨｺｨ 09 ﾂｨｨｨｰ0409ｨ ｨｪｨｨ ｨｰｨ ｨ 04ｨｬｨｨ0104 pxo1 Bacillus anthracis, 06ｨｰ0902 ﾂｨ 06ｨｴｨｨｨｦ 04ｨ 09ｨｨ08ｨｮ0502ｨｪｨｰｨｪ0609ｨｰｨｹ ｨ ｨ 02ｨｨ0505, ｨｪ0209ｨｮｨｴｨ 07 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04ｨｦ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ060904ｨｦ ｨｬ06ｨｰｨｨ09, ｨｪ ｨｬ ｨ ｨｺ, ｨｺ0601ｨｨ08ｨｮ02ｨｬ04ｨｦ 05ｨｰ06ｨｦ 08ｨ ｨｬｨｺ06ｨｦ, ｨｨｨｬ0202ｨｰ 05ｨｨ03ｨｹ 17 % ｨｰ09ｨ ｨｬ060906ｨｬｨｪ04ｨｬ 0006ｨｬ ｨｬ FtsZ ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ06 05ｨｰ06ｨｰ ｨ ｨｺ 09ｨ 0302ｨｪ ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｨ07 ｨ ｨ ｨｺｨｰ0208ｨｨ07ｨｬｨｨ ｨ ｨｪｨｨ04ｨｬｨ ｨｨｨｪｨ (Okinaka et al., 1999; Tinsley, Khan, 2006) ｨｪ06ｨｬ02 Clostridium acetobutylicum ｨｪ04 ｨｺｨ ｨｺ ｨｪ060202ｨｪｨｪ04ｨｦ 0006ｨｬ ｨ 0205ｨｺｨ FtsZ, ｨｰｨ ｨｺ ｨｨ FtsZ ｨ ｨｪ04ｨｦ ｨ ｨｺ, 06ｨ 05ｨ 01ｨ 06ｨｴｨｨｨｦ 05ｨｨ03ｨｹ 14%-ｨｪ04ｨｬ ｨｰ0906ｨｬ 09 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨ ｨｺｨｰｨｨ09ｨｪ06ｨｦ ｨｺ0607ｨｨ02ｨｦ. 06ｨｰ06ｨｰ ｨ ｨｺ ｨｨｨｬ0202ｨｰ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04ｨｦ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ060904ｨｦ ｨｬ06ｨｰｨｨ09, 0601ｨｪｨ ｨｺ06 ｨｪ02ｨｺ06ｨｰ ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰ04, 06ｨｰ0902 ﾂｨ 06ｨｴｨｨ02 09 ｨ 0205ｨｺ02 FtsZ E. coli 04ｨ ｨ ｨｪｨｨ02 ｨｨ 00ｨｨ ｨｨ , 09 FtsZ ｨ ｨｪ06ｨｬ ｨ 0205ｨｺ02 C. acetobutylicum 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｮ06ｨｰ. 0201ｨｪｨｨｨｬ ｨｨ04 ｨｪｨ ｨｨｨ ｨｨｨｪｨｰ ｨｪ0401 ｨｬ0603ｨｪ06 ｨｪｨ 0409ｨ ｨｰｨｹ FtsZ ｨ ｨｪ04ｨｦ ｨ ｨｺ Magnetospirillium magnetotacticum, ｨｨｨｬ0206ｨｴｨｨｨｦ ｨｪ02ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪｨｮ06 04ｨ ｨｬ02ｨｪｨｮ ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰ04 D 1 7 N, 05ｨｺ09ｨｨ09ｨ 0502ｨｪｨｰｨｪ06ｨｦ D 212 FtsZ E. coli ｨｬ06ｨｰ0807 ｨｪｨ 04ｨ ｨｬ02ｨｪｨｮ, FtsZ ｨ ｨｪ04ｨｦ ｨ ｨｺ ｨ 02ｨｪ 0708ｨｨｨｪｨｨｨｬｨ ｨｰｨｹ ｨｮ ﾂｨ 09ｨｰｨｨ ｨ 08ｨ ｨ ｨｪｨｨｨｨ 0002ｨｰ ｨｨｨｬ ｨｨ ｨｪ04ｨｬｨｨ ｨｬ06ｨｪ06ｨｬ0208ｨ ｨｬｨｨ ｨ ｨｪｨ 07 04ｨ ｨｬ02ｨｪｨ ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰ04 ｨｨｨｬ0202ｨｰ ｨｬ0209ｨｰ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ02 05ｨｮｨｺｨ 08ｨｨ06ｨｰ ｨ 09ｨｪ02ｨｪｨｨ06 09 ｨ -ｨｰｨｮｨ ｨｮ05ｨｨｨｪ06ｨｬ. 07 ｨ ｨｪｨ ｨ ｨｪ ｨｰ0907ｨｴ ｨｰ06ｨｰ080600ｨ Chloroflexus aurantiacus 0706ｨｬｨｨｨｬ ｨｪ0608ｨ 04ｨｬ0208ｨｪ06ｨｦ ｨｺ0607ｨｨｨｨ 0002ｨｪｨ ftsz 06ｨ ｨｪｨ 08ｨｮ0302ｨｪｨ ftsz ｨ ｨｪｨ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｹ, 0706ｨｰ ｨ 07 ｨｰ0802ｨｰｨｹ 0002ｨｪｨ 09 N-ｨｺ06ｨｪ02ｨ. 0308ｨｨ 05ｨｰ06ｨｬ 09 09ｨｰ08ｨｮｨｺｨｰｨｮ0802 ｨ 0205ｨｺｨ C. aurantiacus, ｨｺｨ ｨｺ ｨｨ ｨｮ ｨ 0205ｨｺ0609 ｨ ｨｦ, ｨｬ0603ｨｪ06 ﾂ02ｨｰｨｺ ｨｨｨｰｨｹ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04ｨｦ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ060904ｨｦ ｨｬ06ｨｰｨｨ09 (Vaughan et al., 2004). 0209ｨ FtsZ ｨ ｨｪ0401 ｨ 0205ｨｺｨ Methanopyrus kandleri, 0706ｨｬｨｨｨｬ06 ｨｰ ﾂｨｰ06 06ｨ 05ｨ 01ｨ 06ｨｰ ｨｬｨｨｨｪｨｨｨｬｨ 05ｨｹｨｪ04ｨｬ ｨｰ0906ｨｬ ｨｰｨ 05ｨｹｨｪ04ｨｬｨｨ ｨ 0205ｨｺｨ ｨｬｨｨ FtsZ, 02ｨｴ02 ｨｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 ｨｺ ﾂ ｨｨ ｨｰｨｪ ｨｬ FtsZ FtsZ ｨ ｨｪ0402 ｨ 0205ｨｺｨｨ, ｨｨ ｨｰｨｪ ｨｪ07, ｨｮｨｰ08ｨ ｨｰｨｨ05ｨｨ ｨ ｨｪ0609ｨｰｨｹ ｨ ｨｰｨｹ ｨｨ 00ｨｨ ｨｨ040609ｨ ｨｰｨｹ ｨｪｨｮｨｺ050206ｨｰｨｨ ｨｺ06ｨｰ FtsZ ｨ ｨｪ0402 ｨ 0205ｨｺｨｨ, ｨｨ01ｨｨｨｬ06ｨｬｨｮ, ｨｰ ｨｬｨ ｨｬｨｨ FtsZ, ｨｰ ｨｨｨｬｨｨ ｨｨｨｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ ｨｨ ﾂｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ0802 ｨｬ060502ｨｺｨｮ05, ｨｨ ｨｰ09ｨｨ02 05ｨｰ ｨｬ0600ｨｮｨｰ ｨｪ07ｨｰｨｹ 09 ｨｺ0502ｨｰｨｺ ｨｮ00ｨｨ02 00ｨｮｨｪｨｺ02ｨｨｨｨ, ｨｪ ｨ ｨｪｨｪ ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｬ ｨｪｨｨ02ｨｬ. 0201ｨｪ06ｨｦ ｨｨ ｨ 00ｨ 02ｨｬ ｨｮｨｪｨｺ02ｨｨｨｦ FtsZ ｨ ｨｪ0401 ｨ 0205ｨｺ ｨｺ0502ｨｰｨｺ02 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｬｨ 08ｨｺｨｨ080609ｨｺｨ 09ｨ ｨｦｨｰｨ ｨｪｨｨ ｨｰ06ｨｬ 0905ｨｮ ﾂｨ ｨ ｨｰｨｨ ｨｮｨｴ0209ｨｰ ｨｰ 05ｨｨｨ 06 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨ ｨｺｨｰｨｨ09ｨｪ ｨｬ ｨｨ FtsZ, 05ｨｨｨ 06 09ｨｮｨｴ0209ｨｰ09ｨｮ02ｨｰ ｨｨｨｪ06ｨｦ ｨ ｨ ﾂｨｨ 09ｨｨ ｨ ｨｰｨｨ07 ｨｪｨ ｨｬ02ｨｬｨ 08ｨ ｨｪｨｮ ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｺ0502ｨｰｨｺｨｨ, ｨｪ ｨｺ06ｨｰ ｨｨｨｰ ｨｪ02 FtsZ. 01ｨ 0708ｨｨｨｬ0208, ｨｮ ｨｪ02ｨｺ06ｨｰ ｨｰｨ 09ｨｨｨｰ020502ｨｦ Mollicutes ｨｮ05ｨｹｨｰｨ ｨｰ ｨｮｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｨｨｨ, ｨ ｨｰｨ ｨｺ0302 ｨｪｨ 05ｨｨ ﾂｨｨ07 09 ｨｺ0502ｨｰｨｺｨ 01 ｨｬｨｨｨｺ060705ｨ 04ｨｬ ｨｮｨｪｨｨｨｺｨ 05ｨｹｨｪ ｨｪｨｮｨｰ0802ｨｪｨｪｨｨ01 02ｨｨｨｰ0609ｨｺ020502ｨｰｨｪ ｨｰ08ｨｮｨｺｨｰｨｮ08 ｨｬ060005ｨｨ 08ｨ 0409ｨｨｨｰｨｹ0907 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ04 ｨｺ0502ｨｰ06 ﾂｨｪ ｨｪｨｨ07, ｨｺ06ｨｰ ｨｨｨ ｨｬ02ｨｪｨｹ0302ｨｦ 09ｨｰ020702ｨｪｨｨ 04ｨ 09ｨｨ0907ｨｰ 06ｨｰ FtsZ, 05ｨｨｨ ｨ ｨｰ0907 ｨ 0204 ｨｮ ﾂｨ 09ｨｰｨｨ07 05ｨｰ ｨ 0205ｨｺｨ.

4 ｨｨ03ｨｪ07ｨｺ0609, ｨｪｨｨｨｮ ｨｪｨｨ02 ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ ｨ 0204 ｨｮ ﾂｨ 09ｨｰｨｨ07 ｨ 0205ｨｺｨ FtsZ 0308ｨｨ ｨｪ06ｨｬ ﾂｨｰ02ｨｪｨｨｨｨ 0002ｨｪ06ｨｬ ｨｰｨｨ 09ｨｨ ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ, 06ｨｰｨｪ060907ｨｴｨｨ ｨｺ ｨｰｨｨ07ｨｮ Chlamydiae, 0002ｨｪ04, 0006ｨｬ ｨｨ ﾂｨｪ0402 ftsz, 06ｨ ｨｪｨ 08ｨｮ03ｨｨｨｰｨｹ ｨｪ02 ｨｮ01ｨ ｨｹ. 06ｨｰｨｨ ｨ ｨ ｨｺｨｰ0208ｨｨｨｨ ｨｰ ｨ 05ｨｨ00ｨ ｨｰｨｪ04ｨｬｨｨ 07ｨ 08ｨ 04ｨｨｨｰｨ ｨｬｨｨ 0507ｨｨｨｰ0205ｨｨｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ﾂ ｨｺｨ ｨｨ ｨｬ0502ｨｺ0607ｨｨｨｰｨ 06ｨｴｨｨ01. 05ｨｮｨｴ0209ｨｰ09ｨｮ02ｨｰ ｨｰｨｪ0609ｨｰｨｹ ｨｰ060006, ﾂｨｰ ｨ ｨｬｨｨ01ｨｨｨｨ ｨｬ0600ｨｮｨｰ ｨｨ ｨｹ040609ｨ ｨｰｨｹ ｨｨｨｰ06ｨｺｨｨｨｪ0204ｨ ｨ 0707ｨ 08ｨ ｨｰ 06ｨ 08ｨ ｨ ｨｪｨｨ ｨｨｨｺｨｮ ｨｦ09ｨｺ06ｨｦ ｨｺ0502ｨｰｨｺｨｨ, 09 ｨｰ06ｨｬ ﾂｨｨ ｨｨｨｪｨ ｨｬｨｨｨｪ 09 ｨｺｨ ﾂ0209ｨｰ0902 ｨｺ0506 ﾂ ｨ 0205ｨｺｨ ｨｪｨｨ07 (Boleti et al., 1999; Brown, Rockey, 2000). 00ｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ Prosthecobacter dejongeii, ｨｪ06ｨｬ02 ｨｺ06ｨｰ ftsz 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｮ02ｨｰ, ｨｰｨ ｨｺ0906ｨｪ06ｨｬｨｨ ﾂ0209ｨｺｨｨ 06ｨｰｨｪ060907ｨｰ ｨｺ 0905ｨ ｨ 06ｨｨ04ｨｮ ﾂ02ｨｪｨｪ06ｨｬｨｮ ｨｰｨｨ07ｨｮ Verrucomicrobia ｨｹ03ｨｨｨｪ09ｨｰ ｨｰｨ 09ｨｨｨｰ020502ｨｦ 05ｨｰ ｨｰｨｨ07ｨ ｨｰ ｨｺｨｰ0609ｨｨｨｬｨ ｨｨ06ｨｪｨｰｨ ｨｬｨｨ ｨｨｨｪ00ｨｮ040608ｨｨｨｦ. 00 ｨｺ0502ｨｰｨｺ02 P. dejongeii 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ04 ｨｰｨｮｨ ｨｮ050708ｨｪ ｨｰ08ｨｮｨｺｨｰｨｮ0804, ｨｨ02 ｨｪｨ ｨｬｨｨｨｺ0806ｨｰ08ｨｮｨ 06 ﾂｨｺｨｨ 05ｨｮｨｺｨ 08ｨｨ06ｨｰ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨ 0205ｨｺｨｨ, ｨｴｨｨ ｨｰｨ 09 ｨｰｨ ｨｺｨｨ01 09ｨｰ08ｨｮｨｺｨｰｨｮ08, 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ06ｨｰ 09 ｨ ｨｪｨｰｨｨｨｰ0205ｨ ｨｬｨｨ ｨｺ ｨｰｨｮｨ ｨｮ05ｨｨｨｪｨｮ ｨｨｨｪ00ｨｮ040608ｨｨｨｦ (Jenkins et al., 2002). P. dejongeii ｪ ｨ 0601ｨｪ0603ｨｨ09ｨｮｨｴｨ 07 ｨ ｨ ｨｺｨｰ0208ｨｨ07, ｨ ｨｴｨ ｨ 0002ｨｪｨ (btuba ｨｨ btubb), ｨｮｨｺｨｰ04 ｨｺ06ｨｰ ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪ06ｨｦ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨ 05ｨｨ0302 ｨｺ 05ｨｮｨｺｨ 08ｨｨ06ｨｰｨｪ04ｨｬ ｨｰｨｮｨ ｨｮ05ｨｨｨｪｨ ｨｬ, ﾂ02ｨｬ ｨｺ FtsZ ｨｺｨ 08ｨｨ06ｨｰ ｨｪｨｹ ｨｰ09ｨ ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰ02ｨｦ ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ0401 ｨｰｨｮｨ ｨｮ05ｨｨｨｪ0609 BtubA ｨｨ BtubB 09 05ｨｮｨｺｨ 08ｨｨ06ｨｰｨｪ04ｨｬｨｨ ｨ - ｨｨ 09-ｨｰｨｮｨ ｨｮ05ｨｨｨｪｨ ｨｬｨｨ ｨｰｨ ｨｰ 31 ｪ35 ｨｨ 34 ｪ37 % ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ ｨｰｨ 09ｨｨｨｰ020507ｨｬｨｨ 0108ｨｮ00ｨｨ ｨｬ02ｨｦ09ｨｰ09 05ｨｮｨｺｨ 08ｨｨ06ｨｰｨｪ0401 ｨｰｨｮｨ ｨｮ05ｨｨｨｪ ｨｰ ｨｨ ﾂｨｪ ｨｰ08ｨｮｨｺｨｰｨｮ08 05ｨｰｨｨ01 ｨ 0205ｨｺ ｨｬ060502ｨｺｨｮ05 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 ｨｬ02ｨｪｨｹ0302, ｨ ｨｺｨ 08ｨｨ06ｨｰｨｪ04ｨｬｨｨ FtsZ ｨｮ ｨ 0205ｨｺ0609 BtubA ｨｨ BtubB ｨｰ0605ｨｹｨｺ06 8 ｪ11 % ｨｨ0102ｨｪｨｰｨｨ ﾂｨｪ0401 ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪ ｨｰｨ ｨｰｨｺ0609 (Jenkins et al., 2002) ｨｨ ﾂｨｪ ｨｰ08ｨｮｨｺｨｰｨｮ0804 ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ0401 ｨｰｨｮｨ ｨｮ05ｨｨｨｪ0609 P. dejongeii 04ｨ ｨｬ02ｨｰｨｪ06 06ｨｰ05ｨｨ ﾂｨ 06ｨｰ ｨｰ ｨ ｨｬｨｨｨｪ06ｨｺｨｨ090506ｨｰｨｪ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰ02ｨｦ 05ｨｮｨｺｨ 08ｨｨ06ｨｰｨｪ0401 ｨｰｨｮｨ ｨｮ05ｨｨｨｪ ｨｨ ﾂ ｨｪ02 ｨｨ ｨｰｨｪ06 ｨｨ ｨｮ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｨ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ0609 P. dejongeii, ｨｪ06 ｨｪ0201ｨ 09ｨｪ06 ｨ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 06ｨｪｨｨ ｨｬ0600ｨｮｨｰ 06ｨ 08ｨ ｨ ｨｰｨｹ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ04 ｨｨ ｨ ｨｪ ｨ ｨｰｨｹ ｨｨ 00ｨｨ ｨｨ040609ｨ ｨｰｨｹ ｨｪｨｮｨｺ050206ｨｰｨｨ0104 (Sontag et al., 2005). 0809ｨｰ ｨ 00ｨ 06ｨｰ, ﾂｨｰ ｨｪ04, ｨｺ0601ｨｨ08ｨｮ06ｨｴｨｨ02 05ｨｰｨｨ ｨ 0205ｨｺｨｨ, ｨ 0405ｨｨ 0708ｨｨ06ｨ 0802ｨｰ02ｨｪ ｨｺ060906ｨｦ ｨｬ06ｨｦ P. dejongeii 07ｨｮｨｰ02ｨｬ ｨｨ0406ｨｪｨｰｨ 05ｨｹｨｪ ｨｪ0609ｨ ｨｹ04ｨｮ 05ｨｰ06ｨｦ ｨｰ06 ﾂｨｺｨｨ ｨｪｨｨ ｨｨｨｰ ｨｰ06ｨｰ 00ｨ ｨｺｨｰ, ﾂｨｰ ｨｮ00ｨｨ02 09ｨｨ0104 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609 ｨｰｨｨ07ｨ Verrucomicrobia ｨｪ02 ｨｨｨｬ0206ｨｰ 0002ｨｪ0609 ｨｰｨｮｨ ｨｮ05ｨｨｨｪ ｨ ｨｪ0401 ｨ 0205ｨｺ ｨｨ ｨｪ02ｨｨ ｨｰｨｪ06, ｨｺｨ ｨｺ ｨｰ0907 ｨｬｨｨｨｺ060705ｨ 04ｨｬ04 U. parvum ｨｨ M. mobile, 06ｨｰｨｪ060907ｨｴｨｨ ｨｺ ｨ ｨ ｨｺｨｰ0208ｨｨ07ｨｬ, ｨ ｨｰｨ ｨｺ0302 ｨ ｨｨ ｨｰｨｨ07ｨ Crenarchaeota. 0308ｨｨ ｨｪ06ｨｬ ﾂｨｰ02ｨｪｨｨｨｨ 0002ｨｪ06ｨｬ0609 ｨｮ 05ｨｰｨｨ01 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609 ｨｪ02 ｨ ｨ ｨｪｨ 08ｨｮ0302ｨｪ06 ｨｪｨｨｨｺｨ ｨｺｨｨ ｨｪ0609, ｨｺ06ｨｰ ｨｬ060005ｨｨ ｨ 04 ｨｺ0601ｨｨ080609ｨ ｨｰｨｹ ｨ 0205ｨｺｨｨ, 0006ｨｬ ｨｨ ﾂｨｪ0402 ｨｰｨｮｨ ｨｮ05ｨｨｨｪｨ ｨｬ 05ｨｮｨｺｨ 08ｨｨ06ｨｰ, 05ｨｨｨ 06 ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ04ｨｬ ｨｰｨｮｨ ｨｮ05ｨｨｨｪｨ ｨｬ, 05ｨｨｨ 06 ｨ 0205ｨｺｨ ｨｬ FtsZ, 05ｨｨｨ 06 05ｨｮｨｺｨ 08ｨｨ06ｨｰｨｪ04ｨｬ 01ｨｨｨｪｨ ｨｬｨｨｨｪｨ ｨｬ ｨｬｨｨ080609ｨ ｨｪｨｨ02 ｨｨ ｨｮ050702ｨｨ07 09ｨ 0608ｨｺｨｨ Z-ｨｺ0605ｨｹ02ｨ 02 ﾂｨｨｨｴ02ｨｪｨｪ04ｨｦ ｨ ｨｺ FtsZ, ｨｰｨ ｨｺ 0302 ｨｺｨ ｨｺ ｨｨ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ04, 06ｨ 05ｨ 01ｨ 02ｨｰ ｨ ｨｪ0609ｨｰｨｹ06 ｨｺ ｨ ｨｪｨｨ06 ｨｨ 00ｨｨ ｨｨ04ｨｮ ｨｮ05ｨｹｨｰｨ ｨｰ ｨ ｨｪｨｨ ｨｨ ｨｨｨｰ 06ｨ 08ｨ ｨ ｨｪｨｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609, ｨｰｨ ｨｴｨｨ ｨ 06ｨｦ 05ｨｨｨｪ02ｨｦｨｪ ｨｨｨｬ FtsZ, ｨｬ060502ｨｺｨｮ0504 ｨｺ0506 ﾂ ｨ 0205ｨｺｨ ｨｪｨｨ07 08ｨ ｨ 00ｨ 06ｨｰ ｨｨｨｪ02ｨｨ07ｨｮ ｨ ｨｺ ｨｰｨｮ ｨｬ02 05ｨｨｨｪ02ｨｦｨｪ ｨｨｨｬ FtsZ in vitro 06ｨ 08ｨ 04ｨｮ02ｨｰ0907 ｨｪ02ｨｺ06ｨｰ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｬｨｨｨｪｨｨ-ｨｺ (Erickson, Stoffler, 1996) ｨｰｨｪ06, ﾂｨｰ06 ｨ /09-ｨｰｨｮｨ ｨｮ05ｨｨｨｪ ｨｺ0806ｨｬ02 09ｨ ｨｬｨｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609 ｨｨ ｨｬｨｨｨｪｨｨ-ｨｺ ｨ 02ｨｪ 06ｨ 08ｨ ｨ ｨｰｨｹ ｨｬｨｨｨｺ0806ｨｰ08ｨｮｨ 06 ﾂｨｺｨｨ, ｨｰ0607ｨｴｨｨ02 ｨｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ04 FtsZ ｨｪ02 09ｨｺ05ｨ ｨ 06ｨｰ ｨｰ08ｨｮｨ 06 ﾂｨｺｨｨ, ｨｪ ｨ ｨｪ ｨｬｨｨ080609ｨ ｨｰｨｹ 05ｨｨ09ｨｰ04, ｨｨｨｪ070709ｨｹ 0108ｨｮ ｨｮ0006ｨｬ ｨ 06ｨｺ060904ｨｬｨｨ ｨｪ0609ｨｰ07ｨｬｨｨ (L02we, Amos, 1999). 0308ｨｨ ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ 09ｨ 0608ｨｺ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609 FtsZ in vitro ｨｬ020301ｨｮ 0109ｨｮｨｬ07 ｨ ｨｨｨｨ080609ｨ 0903ｨｨｨｬｨｨ ｨｬ06ｨｪ06ｨｬ0208ｨ ｨｬｨｨ ｨｬｨｨ08ｨｮ02ｨｰ0907 ｨ ｨｺｨｰｨｨ09ｨｪ04ｨｦ 09ｨ ｨｦｨｰ 00ｨｨ ｨｨ04ｨ ｪ ｨｪｨ ｨ ｨｨ02 ｨｰｨ ｨｺ ｨｰｨｮｨ ｨｮ05ｨｨｨｪ ｨｬｨｨｨｺ0806ｨｰ08ｨｮｨ 06 ﾂｨｺｨ 01 (Scheffers et al., 2002). 0201ｨｪｨ ｨｺ06 02ｨｨｨｺ ｨ 0608ｨｺｨｨ ｪ08ｨ 04ｨ 0608ｨｺｨｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609, ｨｰ0607ｨｴｨｨ01 ｨｨ04 01ｨｨｨｬ FtsZ, ｨｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609, ｨｰ0607ｨｴｨｨ01 ｨｨ ｨｰ ｨｨｨｬ ｨ /09-ｨｰｨｮｨ ｨｮ05ｨｨｨｪｨ, 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 08ｨ 0405ｨｨ ﾂｨ 06ｨｰ ｨｨ02ｨｬ 08ｨ 04ｨ 0608ｨｺｨｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609 FtsZ ｨｰ ｨｨ ｨｨ ｨ ｨｪｨｪ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ ｨｨ ｨｨ09ｨｰ06ｨｴ02ｨｪｨｨｨｨ 07ｨｮ05ｨ ｨ 0601ｨｪ ｨｨ 00ｨｨ ｨｨ ｨ ｨｪｨｪ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ04 FtsZ 08ｨ 0907ｨ 01ｨ 06ｨｰ ｨｨｨｰ060705ｨ 04ｨｬ02 ｨｺ0502ｨｰｨｺｨｨ, ｨｺ06ｨｰ0608ｨ 07 ｨ 0600ｨ ｨｰｨ , ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ04 FtsZ ｨｮ09ｨｰ06ｨｦ ﾂｨｨ0904, ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ ｨｪ ｨｨ ｨｨｨｰ (Romberg, Levin, 2003) ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609 FtsZ ｨｬｨｨｨｺ0806ｨｰ08ｨｮｨ 06 ﾂｨｺｨｨ 05ｨｮｨｺｨ 08ｨｨ06ｨｰ ｨｰ0607ｨｰ ｨｨ04 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ02 ｨｰｨｮｨ ｨｮ05ｨｨｨｪｨ, ｨ ｨｪｨｪ , ｨｨ 05ｨｨ03ｨｹ ｨｺ06ｨｪ ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ0204 (ｨｺ0507) ｨｪ0209ｨｮｨｰ ｨｨ ｨｨ04 ｨｺ06ｨｪ ｨｨ090601ｨｨｨｰ ｨｺ ｨ 0409ｨｰ0806ｨｦ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ ｨｬｨｨｨｺ0806ｨｰ08ｨｮｨ 06- ﾂ02ｨｺ (Desai, Mitchison, 1997) ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ FtsZ 09ｨ 0608ｨｺｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ ｨｰ0907 ｨｺ ｨ ｨｰｨｨ09ｨｪ06ｨｦ, ｨｰ. 02. ｨ 0000ｨｨｨｪｨｪ0609ｨｰｨｹ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ ｨｰｨｪ060302ｨｪｨｨ ｨｮ00 ｨｺ 0108ｨｮ00ｨｮ ｨ 09ｨｰｨ 02ｨｰ 0708ｨｨ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨ 0205ｨｺ ｨｬ060502ｨｺｨｮ05 (Romberg et al., 2001; Chen et al., 2005). 00 ｨｪｨ ﾂｨ ｨ ｨ ｨｺ FtsZ 06ｨ 08ｨ 04ｨｮ02ｨｰ 01ｨｨｨｬ020804, ｨｺ06ｨｰ , ｨ , 0906ｨ ｨｨ08ｨ 06ｨｰ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ ｨｺ ｨｨｨｬ02ｨｪｨｰ02 04ｨ ｨｬ02ｨｪｨ ｨｪｨ ｨｰｨ ｨｺ ｨｨ090601ｨｨ05ｨ ｨｺ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ FtsZ, 0601ｨｪｨ ｨｺ ｨｰ06ｨｬ 0905ｨｮ ﾂｨ 02 ｨｪｨ ｨ ｨ 05ｨｨ 06ｨ 08ｨ ｨ ｨｪｨｨ02 ｨｨ040600ｨｪｨｮｨｰ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609 (Lu et al., 2000) ｨｰｨｨ0302ｨｪｨｨｨｨ ｨｪｨｪ06ｨｦ 0105ｨｨｨｪ04 ｨｺ06ｨｪ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰｨ ｨ ｨｪ ｨｰｨｮ07ｨ ｨｰｨｹ 09 ｨｺ06ｨｪｨｰｨ ｨｺｨｰ 0108ｨｮ ｨｮ0006ｨｬ. 02ｨ 08ｨ 04ｨｮ06ｨｴｨｨ ｨｨ 05ｨｰ06ｨｬ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰｨｪ0402 ｨｺ0605ｨｹ02ｨ 01ｨｨｨ ｨｬ02ｨｰ0806ｨｬ 09 ｨｪ0209ｨｺ0605ｨｹｨｺ ｨｰ02ｨｪ ｨｪｨ ｨｪ06ｨｬ02ｨｰ ｨ 0405ｨｨ ｨｪ ｨｨ 0706ｨｬ06ｨｴｨｨ ｨｺｨｰ0806ｨｪｨｪ06ｨｦ ｨｬｨｨｨｺ080609ｨｺ0607ｨｨｨｨ (Gonzalez et al., 2005). 00 ｨｺ0502ｨｰｨｺｨ 01 03ｨｰｨ ｨｬｨｬ ｨｨｨｺ ｨｰｨｨ07ｨ E. coli ｨｨ B. subtilis ｨｪ0201ｨ 09ｨｪ06 ｨ 0405ｨｨ 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ ｨｨｨｪｨｪ ｨｨ08ｨ 05ｨｹｨｪ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ04 FtsZ, ｨｪｨ 0409ｨ ｨｪｨｪ0402 Z-0907ｨｨ08ｨ 0507ｨｬｨｨ (Ben-Yehuda, Losick, 2002; Thanedar, Margolin, 2004) ｨｰｨ ｨｰｨｨ09ｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01 B. subtilis, ｨｺｨ ｨｺ ｨｨ 09 ｨｺ0502ｨｰｨｺｨ 01 E. coli, Z-0907ｨｨ08ｨ 05ｨｨ ｨｪ ｨｦ ｨｪ0609ｨｰｨｨ ｨｺ0502ｨｰｨｺｨｨ, 06ｨｪｨｨ 08ｨ ｨ 00ｨ 06ｨｰ0907 ｨｨ ｨｪｨ 01 ｨｪｨｮｨｺ050206ｨｨ0106ｨｬ ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ06 Z-ｨｺ0605ｨｹ ｨｬｨｨ08ｨｮ02ｨｰ ｨｮ05ｨｹｨｰｨ ｨｰ02 09ｨ 0608ｨｺｨｨ 05ｨｰｨｨ ｨｨ08ｨ 0502ｨｦ 09 07ｨｮ ﾂ06ｨｺ ｨｨｨｪ02 ｨｺ0502ｨｰｨｺｨｨ (Michie et al., 2006). 08ｨｪｨ ｨｨ ﾂｨｪ0402 Z-0907ｨｨ08ｨ 05ｨｨ ｨ 0405ｨｨ ｨｪ04 ｨｨ ｨｪｨ ｨｪ0609ｨｰｨｨ ｨｺ0502ｨｰ06ｨｺ Mycobacterium tuberculosis, 09 ｨｮ ｨｨ0701 ｨｺ060001ｨ ｨｰｨ 02ｨｨ07 ｨ 0405ｨ ｨ ｨｪｨ, ｨｨ ｨｰ0605ｨｹｨｺ06 ｨｪｨ ｨｴｨｨ ｨｺ0502ｨｰｨｺｨ 01 05ｨｰｨｨ 0907ｨｨ08ｨ 05ｨｨ 0906ｨ ｨｨ08ｨ 05ｨｨ09ｨｹ 09 Z-ｨｺ0605ｨｹ0206 (Chauhan et al., 2006) ｨ 0608ｨｺｨｨ, ｨｪ ｨｰ02ｨｬ ｨｺｨ ｨｺ ｨｪｨ ﾂｨｨｨｪｨ 02ｨｰ ｨ ｨｰｨｨ07, Z-ｨｺ0605ｨｹ ｨｰｨ ｨｰ ｨｰｨ ｨ ｨｨ05ｨｹｨｪ04ｨｬ. 0201ｨｪｨ ｨｺ06 ｨ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 in vivo Z-ｨｺ0605ｨｹ ｨｺ0601ｨｨｨｪｨ ｨｬｨｨ ﾂｨｪ06 ｨｪｨ ｨｰ070302ｨｪｨｨｨｨ ｨｮｨｴ0209ｨｰ090609ｨ ｨｪｨｨ07: ｨ 0601ｨｪ ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ0204 FtsZ ｨ 0409ｨｰ ｨ ｨｬ02ｨｪｨｨ09ｨ 06ｨｰ ｨｺ0605ｨｹ0206ｨｬ ( ｨｬ02ｨｪ02ｨｬ ｨｮ03ｨｨ04ｨｪｨｨ 8 ｪ9 09). 06ｨ ｨｺ ｨｬ ｨｮ03ｨｨ04ｨｪｨｨ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ02 ｨｮ09ｨｰｨ ｨｪ ｨｪ ｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨｨｨ 01ｨｨｨｪｨ ｨｬｨｨｨｺｨｨ 09ｨ 0608ｨｺｨｨ Z-ｨｺ0605ｨｹ02ｨ ｨｮ B. subtilis ｨｨ E. coli ｨｰｨ 09 ｨｺ0605ｨｹ02ｨ ｨｨｨｰ ｨｰ0605ｨｹｨｺ06 06ｨｺ % 09ｨｮｨｬｨｬｨ 08ｨｪ FtsZ ｨｺ0502ｨｰｨｺｨｨ. Z-ｨｺ0605ｨｹ ｨｰｨ ｨｰ 0906ｨ 06ｨｦ 07ｨｮ ﾂ06ｨｺ ｨｨ05ｨｨ ｨｺｨｮ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609, ｨｺ06ｨｰ ｨｪｨ ｨｰ ｨｰ0607ｨｪｨｨｨｨ ｨｰ0607ｨｪｨｪ ｨ ｨｬ02ｨｪｨ 09 07ｨｮ0506ｨｬ ｨｬ06ｨｪ06ｨｬ ｨｨ 0605ｨｨ0006ｨｬ FtsZ, 06ｨ 08ｨ 04ｨｮ06ｨｴｨｨ ｨｨｨｰ060705ｨ 04ｨｬ ｨｨ 05ｨｰ06ｨｬ ｨｺｨｨｨｦ ｨｮ ｨｪｨｹ 06ｨ ｨｰｨ ｨｬ06ｨｪ06ｨｬ ｨｪ ｨ ｨｪ 09 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 ｨｺ0605ｨｹ02ｨ (Anderson et al., 2004).

5 ｨｺ FtsZ ｨｨ 02ｨｨｨｰ06ｨｺｨｨｨｪ0204 ｨｮ ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ ｨ 08ｨ ｨｰ ｨｪｨｨ07 ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｺ0502ｨｰｨｺｨｨ (01ｨｨ09ｨｨ0906ｨｬｨ ) ｨｪｨ 0708ｨｨｨｬ Escherichia coli. ｨ ｪ ｨｬｨ 01ｨｨ09ｨｨ0906ｨｬ04 ｪ ﾂ ｨｺ0502ｨｰ06 ﾂｨｪｨｮ06 ｨｬ02ｨｬｨ 08ｨ ｨｪｨｮ ｨｺ ｨｺ0605ｨｹ02ｨ 0903ｨ ｨｰｨｨ07, 0708ｨｨｨｬ0208ｨｪ ｨ ｨｨｨｬ0608ｨ ｨｪｨｨ ｨｪ0609ｨｪ0401 ｨ 0205ｨｺ0609; ｨ ｪ ｨｺ 09ｨ 0608ｨｺｨｨ 01ｨｨ09ｨｨ0906ｨｬ04. FtsZ ｪ ｨｺ0506 ﾂ020906ｨｦ ｨ ｨｺ ｨｪｨｨ07, 06ｨ 08ｨ 04ｨｮ06ｨｴｨｨｨｦ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ04. 03ｨｮ ﾂ06ｨｺ 05ｨ ｨｰ0208ｨ 05ｨｹｨｪ ｨ ｨｪｨｪ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ ｨｰｨ ｨｰ 0609ｨｪ0609ｨｮ Z-ｨｺ0605ｨｹ02ｨ ｨｺ ZipA ｨｰ0802ｨ ｨｮ02ｨｰ ｨ 07ｨｺ0608ｨｨ09ｨ ｨｪｨｨ07 FtsZ ｨｪｨ ｨｬ02ｨｬｨ 08ｨ ｨｪ02. FtsA ｪ ｨ 06ｨｴｨｨｨｦ ｨ ｨｺ, ｨ ｨｪ04ｨｦ ｨｺ 06ｨ 08ｨ ｨ ｨｪｨｨ06 01ｨｨｨｬ ; 06ｨｪ ｨｮ ﾂｨ 09ｨｰ09ｨｮ02ｨｰ 09 09ｨｰｨ ｨ ｨｨ05ｨｨ04ｨ 02ｨｨｨｨ Z-ｨｺ0605ｨｹ02ｨ ｨｨ 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ02ｨｰ 09 FtsI. FtsK ｪ ｨ ｨｺ ｨ 0605ｨｹ ｨ 04ｨｬ0208ｨ, ｨｪｨ N-ｨｺ06ｨｪ ｨ ｨｪ04 ﾂ02ｨｰ ｨｰ08ｨ ｨｪ09ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ ｨｬ02ｨｪｨ, C-ｨｺ06ｨｪ ｨｦ 0106ｨｬ02ｨｪ 06ｨ ﾂｨｨ09ｨ 02ｨｰ ｨ 09ｨｨ09ｨｨｨｬｨｮ06 ｨｰ08ｨ ｨｪ090506ｨｺｨ 02ｨｨ06 ｨ 0205ｨｺｨ ｨｹ ｨｬ060906ｨｬ04, ｨ 0605ｨｹ0306ｨｦ 02ｨｨｨｰ060705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ 0106ｨｬ02ｨｪ ｨｮ ﾂｨ 09ｨｰ09ｨｮ02ｨｰ ｨ 02ｨｨｨｨ ｨｬ060906ｨｬ ｨｺｨｨ FtsQ, FtsN, FtsL ｨｨ FtsI ｨｰ0607ｨｰ ｨｨ ｨｮ ｨｬ02ｨｪ0609 ｪ ｨｰ08ｨ ｨｪ09ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ ｨｨ ｨｨ0705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ FtsB ｨｨｨｰ ｨｰｨ 09 01ｨｨ09ｨｨ0906ｨｬ04 09 ｨｺ06ｨｬ070502ｨｺ ｨｰ08ｨ ｨｪ09ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ04ｨｬｨｨ ｨ 0205ｨｺｨ ｨｬｨｨ FtsN, FtsL ｨｨ FtsQ. FtsL ｪ ｨｰ08ｨ ｨｪ09ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ04ｨｦ ｨ ｨｺ ｨｬｨ ｨ 04ｨｬ0208ｨ, 06ｨ 08ｨ 04ｨｮ02ｨｰ 01ｨｨｨｬ ｨｺｨｮ05ｨ ｨ 0205ｨｺｨ FtsW ｨｨｨｰ 10 ｨｰ08ｨ ｨｪ09ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ0401 ｨｮ ﾂｨ 09ｨｰｨｺ0609; ｨ 00ｨ 02ｨｬｨ 07 00ｨｮｨｪｨｺ02ｨｨ07 ｪ ｨｰ08ｨ ｨｪ090506ｨｺｨ 02ｨｨ ｨｰ0902ｨｪｨｪｨｨｨｺ ｨｰｨｨ ｨｨｨｺｨ ｨｪ ｨｨｨｪｨｰ0204ｨ, ｨ ｨｪｨｪ ｨｨ07ｨｨ01ｨ ｨｬｨｨ. FtsI (PBP3) ｪ 0702ｨｪｨｨ02ｨｨ05ｨｨｨｪ ｨ 06ｨｴｨｨｨｦ ｨ ｨｺ, ｨｪ0206ｨ ｨｨｨｬ04ｨｦ ｨｨｨｪｨｰ0204ｨ ｨｬｨ ｨｰ0208ｨｨｨ 05ｨ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 09ｨｰ02ｨｪｨｺｨｨ ｨｪｨ 09ｨｪ0609ｨｹ 06ｨ 08ｨ 04ｨｮ06ｨｴｨｨ ｨ ｨｺｨｮ05ｨ FtsN ｨｨｨｰ N -ｨｺ06ｨｪ ｨｦ ｨｰ08ｨ ｨｪ09ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ04ｨｦ ｨｬ02ｨｪｨｰ, ｨｪｨ 0708ｨ ｨｴｨｨｨｦ ｨｰ08ｨ ｨｪ090506ｨｺｨ 02ｨｨ06 ｨ 0605ｨｹ C-ｨｺ06ｨｪ ｨｬ02ｨｪｨ ｨｪｨ ｨｨ0705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｮ06 09ｨｰ060806ｨｪｨｮ ｨｬ02ｨｬｨ 08ｨ ｨｪ04; ｨｰｨｪ06, 06ｨｪ ｨｮ ﾂｨ 09ｨｰ09ｨｮ02ｨｰ 09 00ｨｨ ｨｨ0402 ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 09ｨｰ02ｨｪｨｺｨｨ 0708ｨｨ ｨｨｨｪｨｨ02ｨｨｨ 02ｨｨｨｨ 02ｨｨｨｰ06ｨｺｨｨｨｪ0204ｨ (0706: Margolin, 2005, 09 ｨｬ0601ｨｨ00ｨｨｨｺｨ 02ｨｨ07ｨｬｨｨ). 02ｨ ｨｴ0202 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｬ060502ｨｺｨｮ05 FtsZ 09 ｨｺ0502ｨｰｨｺ02 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ ｨ 02ｨｰ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ06, ｨｪ0206ｨ ｨｨｨｬｨｮ ｨｬｨｨ080609ｨ ｨｪｨｨ07 Z-ｨｺ0605ｨｹ02ｨ. 06ｨｰ06 ｨｮｨｺｨ ｨ 02ｨｰ ｨｪｨ 09ｨｮｨｴ0209ｨｰ090609ｨ ｨｪｨｨ02 ｨｨｨｪ00ｨｨｨ ｨｨｨｰ , 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ06ｨｴｨｨ01 09 ｨ 0205ｨｺ06ｨｬ ｨｨ ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ FtsZ ｨｨ 09ｨ 0608ｨｺ02 ｨ 0707ｨ 08ｨ ｨｰｨ ｨｪｨｨ ｨｨ ｨｹｨｪ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ. 0201ｨｨｨｪ ｨｨ ｨｬ0603ｨｪ ｨ ｨｰ08ｨ ｨｪ09ｨｰ0902ｨｪｨｪ06ｨｦ ｨｮ050702ｨｨｨｨ ｨｬｨｨ080609ｨ ｨｪｨｨ ｨ ｨｪ ｨｪｨｨ ｨ ｨｪ ｨｰ0607ｨｪｨｨ02ｨｬ ｨｪｨｮｨｺ050206ｨｨ01ｨ. 00 ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｺ0502ｨｰｨｺ ｨｰｨｹ ｨｰ0605ｨｹｨｺ06 ｨｰ08ｨｨ 06ｨ 05ｨ 09ｨｰｨｨ, ｨｨｨ 06 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｮ02ｨｰ ｨｬ, 05ｨｨｨ ｨｨ09ｨｮｨｰ09ｨｰ09ｨｮ02ｨｰ 09 ｨｬｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ ｨｪｨ ｨｨ04 ｨｰｨ ｨｺｨｨ01 06ｨ 05ｨ 09ｨｰ02ｨｦ 06ｨ 08ｨ 04ｨｮ02ｨｰ0907 ｨｺ ｨｪｨ ﾂｨ 05ｨｮ 02ｨｨｨｰ06ｨｺｨｨｨｪ0204ｨ ｨｬ020301ｨｮ ｨｨ080609ｨ ｨｪｨｪ04ｨｬｨｨ ｨｬ060906ｨｬｨ ｨｬｨｨ ｨｨｨｪ02 ｨｺ0502ｨｰｨｺｨｨ, 0108ｨｮ00ｨｨ ｨ ｨｰ ｨｪｨ ｨ 01 ｨｺ0502ｨｰｨｺｨｨ ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ06 06ｨ 05ｨ 09ｨｰｨｹ ｨｬ0603ｨｪ06ｨｦ 09ｨ 0608ｨｺｨｨ Z-ｨｺ0605ｨｹ02ｨ ｨｰ ｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｪｨｨ ﾂ02ｨｪｨ ｨ 09ｨｪ06 ｨ 0405ｨｨ ｨｪ04 ｨ 0205ｨｺｨｨ, 06ｨ 05ｨ 01ｨ 06ｨｴｨｨ02 ｨｬｨｪ ｨｰ0902ｨｪｨｪ04ｨｬｨｨ 09ｨ ｨｦｨｰｨ ｨｬｨｨ ｨ ｨｪｨｨ ｨｬ060906ｨｬｨｪ06ｨｦ , ｪ SlmA (E. coli) ｨｨ Noc (B. subtilis), ｨｺ06ｨｰ060804ｨｬ 0708ｨｨ07ｨｨ090409ｨ 02ｨｰ ｨｮｨｪｨｺ02ｨｨ07 ｨｰｨ ｨｺｨｨ01 ｨｰ ｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｪｨｨ ﾂｨｨｨｰ020502ｨｦ (Wu, Errington, 2004; Bernardt, de Boer, 2005). 06ｨｰｨｨ ｨ 0205ｨｺｨｨ, ｨｰｨｪ06, ｨｪ ｨｰ09ｨｰ09ｨｮ06ｨｰ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ FtsZ, 0706 ｨｺ08ｨ ｨｦｨｪ02ｨｦ ｨｬ ｨｮ B. subtilis. 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨ ｨｺ FtsZ B. subtilis ｨ 02ｨｪ ｨｨｨｬ0208ｨｨ ｨ ｨｰｨｹ0907 ｨｨ 06ｨ 08ｨ ｨ ｨｰｨｹ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ04, ｨ 06ｨｴｨｨ ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪｨｮ06 ｨｺ0502ｨｰｨｺｨｮ ｨｨ08ｨ 05ｨｨ ｨｨ 05ｨｰ06ｨｬ ｨｬｨｨ080609ｨ ｨｪｨｨ02 Z-ｨｺ0605ｨｹ02ｨ ｨｬ ｨｪｨｨ ｨｨ ｨｨｨｰ 09ｨｰ ｨｨｨｪ02 ｨｺ0502ｨｰｨｺｨｨ, ｨｬ020301ｨｮ 0109ｨｮｨｬ07 08ｨ ｨｨｨｬｨｨ ｨｬ060906ｨｬｨ ｨｬｨｨ. 0906ｨｰ07 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ 00ｨｪｨｮｨｺ050206ｨｨ01ｨｪ06ｨｦ ｨ ｨｨ ｨｪ ｨｪ, ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ06 ｨ 0205ｨｺｨｨ SlmA ｨｨ Noc ｨｰ0908ｨ ｨｴｨ 06ｨｰ ｨ ｨｪｨｨ04ｨ 02ｨｨ ｨｨｨｪｨｪ ｨｨ08ｨ 05ｨｹｨｪ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609 FtsZ 09 ｨｺ0605ｨｹ020209ｨｮ06 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｮ ｨｪｨ 01 ｨｪｨｮｨｺ050206ｨｨ0106ｨｬ (Michie et al., 2006) ｨｰ06ｨｬｨｮ ｨｰｨｪ0609ｨｰｨｹ 09ｨ 0608ｨｺｨｨ Z-ｨｺ0605ｨｹ02ｨ ｨｨｨｪ02 ｨｺ0502ｨｰｨｺｨｨ, ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ ｨｺｨ ｨ 02ｨｰ0907 ｨｪｨ ｨｨｨｬ02ｨｪｨｹ0302ｨｦ, ｨ 02ｨｨｨｨ ｨｬ060906ｨｬ ｨｮ090205ｨｨ ﾂｨｨ09ｨ 02ｨｰ ｨ ｨ 01 ｨｺ0502ｨｰｨｺｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ ｨｰ ｨｪｨｨ0302ｨｪｨ ｨｰ06ｨｬｨｮ ｨ 08ｨ 0909ｨｬｨ ｨｰ08ｨｨ09ｨ 06ｨｰ0907 ｨｺｨ ｨｺ 0706ｨｰ02ｨｪ02ｨｨｨ 05ｨｹｨｪ ｨ ｨｦｨｰ04 ｨ ｨｮ01ｨｮｨｴｨｨ ｨｪｨｨｨｦ. 07 E. coli ｨｨｨｬ0202ｨｰ ｨｨｨ 05ｨｹｨｪｨ 07 09ｨｨ09ｨｰ02ｨｬｨ, ｨ 0506ｨｺｨｨ08ｨｮ06ｨｴｨ 07 06ｨ 08ｨ ｨ ｨｪｨｨ02 01ｨｨ09ｨｨ0906ｨｬ04 ｨｪｨ ｨ ｨｰｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ ｨｺ0506 ﾂｨ 02ｨｰ ｨ 07 ｨ 0205ｨｺｨｨ MinC, MinD ｨｨ MinE. 02ｨ 0604ｨｪｨ ﾂ02ｨｪｨｨ02 min ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ ｨｪ0609 ｨ ｨｪ ｨｰ06ｨｬｨｮ, ﾂｨｰ06 ｨｬｨｮｨｰｨ ｨｪｨｰ ｨ ｨｪｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ02 01ｨ 06ｨｰ ｨｪｨ ﾂｨ 0506 ｨｬｨｨｨｪｨｨ-ｨｺ0502ｨｰｨｺｨ ｨｬ, 0708ｨｨ 05ｨｰ06ｨｬ ｨｪｨ ｨｺ0502ｨｰ06 ﾂｨｪ ｨ ｨｨ ｨｨｨｰ ｨｪ02 ﾂｨｰ ｨ ｨｪ ﾂｨｺ0609ｨ ｨｪｨｨ06 (de Boer et al., 1992) ｨｬｨ ｨｬ0603ｨｪ ｨｦ09ｨｰ09ｨｨ07 05ｨｰ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ ｨ ｨｪ ｨｨ09ｨ ｨｪｨ 09 06ｨ ｨ 01 (08ｨｮｨｺ02ｨｺ0609ｨ, ｨｪｨｨｨｮ09, 2000; Errington et al., 2003). 02ｨ 05ｨ 09ｨｰｨｹ ｨｪｨｨ0302ｨｪｨｪ06ｨｦ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ02ｨｦ ｨｨｨｪ02 ｨｺ0502ｨｰｨｺｨｨ 06ｨ 08ｨ 04ｨｮ02ｨｰ0907 ｨｰ0605ｨｹｨｺ06 09 ｨｺ06ｨｪ ｨｨｨｺ05ｨ ｨｨｨｺｨ 02ｨｨｨｨ , ｨｰ06ｨｬｨｮ ｨｰ0607ｨｪｨｨ02 ｨｪｨｮｨｺ050206ｨｨ01ｨ ｨｬ060302ｨｰ 0905ｨｮ03ｨｨｨｰｨｹ ｨｪ02 ｨｰ0605ｨｹｨｺ ｨｰ08ｨ ｨｪ09ｨｰ0902ｨｪｨｪ04ｨｬ, ｨｪ06 ｨｨ ｨｬ02ｨｪｨｪ*04ｨｬ 09ｨｨ00ｨｪｨ 0506ｨｬ ｨｪｨｨ ｨｬ02 ｨｰ060006, 06ｨ 08ｨ ｨ ｨｪｨｨ02 01ｨｨ09ｨｨ0906ｨｬ ｨｨ ｨｨｨｰ 09ｨｰ ｨ 02ｨｨｨｨ ｨｪｨｮｨｺ050206ｨｨ01ｨ, ｨｺ060001ｨ ｨｰ06 ﾂｨｺｨｨ ｨｪｨ ﾂｨ 05ｨ ｨｨｨｺｨ 02ｨｨｨｨ ｨｺｨ ｨ 06ｨｰ ｨ ｨｪｨｪ04ｨｬｨｨ 09 08ｨ ｨｦ06ｨｪ ｨｺ0502ｨｰｨｺｨｨ (Sun et al., 1998). In vitro 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨ ｨｺ FtsZ E. coli 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ02ｨｰ 09 N-ｨｺ06ｨｪ ｨｬ ｨｮ ﾂｨ 09ｨｰｨｺ06ｨｬ ｨ 0205ｨｺｨ ｨ 02ｨｨｨｨ MukB, ｨ ｨｴｨｨｨｬ ｨｪｨｮｨｺ050206ｨｰｨｨ ｨ 06ｨｴｨｨｨｦ 0106ｨｬ02ｨｪ, ｨｨ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ N-ｨｺ06ｨｪ020209ｨ 07 06ｨ 05ｨ 09ｨｰｨｹ ｨｬ060502ｨｺｨｮ0504 MukB ｨｪｨ 0706ｨｬｨｨｨｪｨ 02ｨｰ ｨｰ08ｨｮｨｺｨｰｨｮ ｨｨｨｪｨ ｨｬｨｨｨｪ, ｨｰ060001ｨ ｨｺｨ ｨｺ ｨｹ C-ｨｺ06ｨｪ02ｨ ｨｪ ｨｪ02ｨｪｨ ｨｺ MukB 06ｨ 08ｨ 04ｨｮ02ｨｰ 01ｨｨｨｬ ｨｨ 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ02ｨｰ (Lockhart, Kendrick-Jones, 1998) ｨｰｨｪ06 02ｨｴ02 ｨｪ0209ｨｺ0605ｨｹｨｺ06 ｨ 0205ｨｺ0609, 0905ｨｨ0706ｨｴｨｨ01 ｨｪｨ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ ｪ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ FtsZ ｨｨ ｨｪｨｨ01 ｪ ｨ ｨｺ SOS-06ｨｰ0902ｨｰｨ SulA, 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ06ｨｴｨｨｨｦ 09 FtsZ ｪ ｨｪ ｨ 0506ｨｺｨｨ08ｨｮ02ｨｰ 06ｨ 08ｨ ｨ ｨｪｨｨ02 ｨｺ0605ｨｹ02ｨ 0903ｨ ｨｰｨｨ ｨ 05ｨ 09ｨｰｨｨ ｨ ｨｪｨｨ07, 0106 ｨｰ ｨｺｨ ｨｪ02 ｨ ｨｮ01ｨｮｨｰ 0609ｨｮｨｴ0209ｨｰ090502ｨｪ ｨ 08ｨ 02ｨｨ , 01ｨｮ0705ｨｨｨｺｨ 02ｨｨ ｨｬ060906ｨｬ04 ｨｨ

6 ｨｨ03ｨｪ07ｨｺ0609, ｨｪｨｨｨｮ09 ｨｪ0608ｨｬｨ 05ｨｹｨｪｨ ｨ 02ｨｨ07 ｨｪｨｮｨｺ050206ｨｨ01ｨ ｨｺ ZapA, ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ04ｨｦ ｨｮ ｨｬｨｪ0600ｨｨ01 ｨｬｨｨｨｺ ｨ ｨｪｨｨ04ｨｬ0609, 09ｨｺ0506 ﾂｨ 07 E. coli, 06ｨ ﾂｨｨ09ｨ 02ｨｰ 09ｨｰｨ ｨ ｨｨ05ｨｨ04ｨ 02ｨｨ06 FtsZ-00ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609, 0903ｨｨ09ｨ 07 ｨｨ01 ｨｬ020301ｨｮ 0906ｨ 06ｨｦ ｨｺ-03ｨ ｨｪ ClpX B. subtilis ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ02ｨｰ ｨｬｨｨ080609ｨ ｨｪｨｨ02 Z-ｨｺ0605ｨｹ02ｨ. 01ｨ 0409ｨ ｨｪｨｪ0402 ｨ 0205ｨｺｨｨ, ｨ ｨｰｨ ｨｺ ｨｮ00ｨｨ02 ｨ 0205ｨｺｨｨ ｨｮ0507ｨｰ ｨ 0608ｨｺｨｨ Z-ｨｺ0605ｨｹ02ｨ ｨｰｨ ｨｪ04 09 ｨｪ0201ｨ 09ｨｪ ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｪ06ｨｬ 06ｨ (Margolin, 2005) ｨ 09ｨｪ06 ｨ 0405 ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪ 02ｨｴ ｨｨｨｪ ｨ ｨｺ, 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ06ｨｴｨｨｨｦ 09 FtsZ B. subtilis, ｪ SepF. 05ｨｰ08ｨｮｨｺｨｰｨｮ08ｨ 05ｨｰ ｨ 0205ｨｺｨ 06ｨｺｨ 04ｨ 05ｨ 09ｨｹ ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｬ ｨｨｨｰ0205ｨｹｨｪ0401 ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ, ｨ ｨｬｨｮｨｰｨ 02ｨｨｨｨ ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴ02ｨｬｨｮ 0002ｨｪｨｮ sepf 0708ｨｨ090601ｨｨ05ｨｨ ｨｺ ｨｬｨｨ080609ｨ ｨｪｨｨ ｨｺｨｰｨｪ0401 Z-ｨｺ (Hamoen et al., 2006). 02ｨｨ09ｨｨ0906ｨｬｨ E. coli 05 Z-ｨｺ0605ｨｹ0206ｨｬ ｨｮ E. coli 06ｨｺｨ ｨ 06ｨｰ0907 ｨｰｨ ｨｺ ｨｨ05ｨｨ ｨｨｨｪｨ ﾂ ｨ ｨｪｨｪ04ｨｬｨｨ ｨｪ02 ｨｬ02ｨｪ ｨｰｨｺｨ ｨ 0205ｨｺ0609, ｨｺ06ｨｰ ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ 09 02ｨｨｨｰ06ｨｺｨｨｨｪ (09ｨｬ. 08ｨｨ09ｨｮｨｪ06ｨｺ) ﾂ02ｨｪｨｨ ｨｨ ｨｨｨｰ ｨ ｨｰ0205ｨｹｨｪ06, ｨｪｨ ﾂｨｨｨｪｨ ZipA, ｨｺ06ｨｰ060804ｨｦ ｨｰ0802ｨ ｨｮ02ｨｰ ｨ 05ｨｹｨｪ02ｨｦ0302ｨｦ ｨ ｨｨｨ 02ｨｨｨｨ ｨｰｨ 05ｨｹｨｪ0401 ｨ 0205ｨｺ ｨｪｨｨ ｨｺｨｨ ZipA ｨｨ FtsA ｨｪｨｮ03ｨｪ ｨ 07ｨｺ0608ｨｨ09ｨ ｨｪｨｨ07 FtsZ ｨｪｨ ｨｬ02ｨｬｨ 08ｨ ｨｪ02, 0708ｨｨ ﾂ02ｨｬ 0609ｨｪ0609ｨｪｨ ｨｹ ｨ 06ｨｴ ｨ 0205ｨｺｨ FtsA, ｨｰｨｪ06, ｨｰ06ｨｨｨｰ 09 09ｨｰｨ ｨ ｨｨ05ｨｨ04ｨ 02ｨｨｨｨ Z-ｨｺ0605ｨｹ02ｨ. 07 E. coli FtsA ｨ 02ｨｪ 06ｨ 08ｨ ｨ ｨｰｨｹ 01ｨｨｨｬ020804, 0903ｨｨ09ｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ04 FtsZ ｨｬ020301ｨｮ 0906ｨ 06ｨｦ ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ 05ｨｰ ｨ 0205ｨｺｨ Z-ｨｺ0605ｨｹ0206 ｨｪ02 06ｨ 05ｨ 01ｨ 02ｨｰ ｨ ｨｪ0609ｨｰｨｹ06 ｨｺ 0903ｨ ｨｰｨｨ06 (Ma, Margolin, 1999; Feucht et al., 2001) ｨ 09ｨｪ06 ｨｨ ｨｪｨ B. subtilis ｨ ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 FtsA ｨｪｨｮ0302ｨｪ ｨ 0608ｨｺｨｨ Z-ｨｺ0605ｨｹ02ｨ, 0708ｨｨ ﾂ02ｨｬ ｨｬｨｮｨｰｨ 02ｨｨ ｨｪｨｮ ftsa 0708ｨｨ090601ｨｨ05ｨ ｨｺ 06ｨ 08ｨ ｨ ｨｪｨｨ06 ｨｬ ｨｨ ﾂ0209ｨｺｨｨ ｨｺｨｰｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ0804 (Jensen et al., 2005) ｨｺｨｨ ZipA ｨｨ FtsA ｨｬ0600ｨｮｨｰ 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ090609ｨ ｨｰｨｹ ｨｪ06ｨｦ ｨｨ ｨｰ06ｨｦ ｨ 05ｨ 09ｨｰｨｹ06 ｨｬ060502ｨｺｨｮ0504 FtsZ. 0308ｨｨ 0706ｨｬ06ｨｴｨｨ ｨｦ N-ｨｺ06ｨｪ ｨｦ ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ZipA 04ｨ 07ｨｺ0608ｨｨ09ｨ 02ｨｰ0907 ｨｪｨ ｨｬ02ｨｬｨ 08ｨ ｨｪ02. C-ｨｺ06ｨｪ ｨｦ ｨｮ ﾂｨ 09ｨｰ06ｨｺ ZipA 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ02ｨｰ 09 C-ｨｺ06ｨｪ ｨｬ ｨｺ06ｨｪ ｨ ｨｰｨｨ09ｨｪ04ｨｬ 0106ｨｬ02ｨｪ06ｨｬ FtsZ, 06ｨ ﾂｨｨ09ｨ ｨｰｨｺ ｨ ｨｺ ｨｪｨｨ02 Z-ｨｺ0605ｨｹ02ｨ ｨｪｨ ｨｬ02ｨｬｨ 08ｨ ｨｪ02 ｨｨ ｨ ﾂｨｮ 02ｨｦ ｨｪｨｨ07 ｨｺ0502ｨｰｨｺｨｨ 09ｨｨ ｨ ｨｰｨｨ07 (Ma, Margolin, 1999) ｨｬ06ｨｰ0807 ｨｪｨ ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ0402 ｨｨ ｨ ｨｪｨｨ07 ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ ｨｨｨｰ06ｨｺｨｨｨｪ02ｨｰｨｨ ﾂ0209ｨｺ ｨ 0707ｨ 08ｨ ｨｰｨ, ｨ ｨｨ0601ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ02 00ｨｮｨｪｨｺ02ｨｨｨｨ ｨｨ04ｨｮ ﾂ02ｨｪ04 ｨｰ0605ｨｹｨｺ ｨｮ01 ｨ 0205ｨｺ ｨｦ ｨｨ04 ｨｪｨｨ01 ｪ FtsZ, 09ｨｰ060806ｨｦ ｪ FtsI, ｨｪｨ ｨ 02ｨｬ04ｨｦ ｨｰｨ ｨｺ0302 PBP3 (penicillin-binding protein) ｨｨ04-04ｨ ｨ ｨｪ0609ｨｰｨｨ ｨｨ00ｨｨ ﾂ0209ｨｺｨｨ ｨ ｨｰｨｹ 0702ｨｪｨｨ02ｨｨ0505ｨｨｨｪ. FtsI ｨｪ0206ｨ ｨｨｨｬ ｨｨｨｪｨｰ0204ｨ ｨｬｨ ｨｰ0208ｨｨｨ 05ｨ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 09ｨｰ02ｨｪｨｺｨｨ ｨｪｨ 09ｨｪ0609ｨｹ 06ｨ 08ｨ 04ｨｮ06ｨｴｨｨ ｨ 01 ｨｮ ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ ｨｰｨｨ ｨｨｨｺｨ ｨｪ060906ｨｦ 06ｨ ﾂｨｺ06ｨｦ. FtsI 06ｨ 05ｨ 01ｨ 02ｨｰ ｨｰ08ｨ ｨｪ090005ｨｨｨｺ0604ｨｨ05ｨ 04ｨｪ06ｨｦ ｨｨ ｨｰ08ｨ ｨｪ ｨｰｨｨ01ｨ 04ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ ｨｬ06ｨｰ08ｨｨ02ｨ ｨｰ0205ｨｹｨｪ0401 ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ ｨｪｨｨ07 ｨｺ0502ｨｰｨｺｨｨ 05ｨｰ06ｨｰ ｨ ｨｺ 0102ｨｦ09ｨｰ09ｨｮ02ｨｰ ｨｰｨ 0902 ｨｬｨｮ05ｨｹｨｰｨｨ070806ｨｰ02ｨｨｨｪ ｨｰｨｨ ｨｨｨｺｨ ｨｪ09ｨｨｨｪｨｰ0204ｨｨ08ｨｮ06ｨｴ ｨｺ06ｨｬ070502ｨｺ09ｨ (Holtje, 1998). 0209ｨｰｨ 05ｨｹｨｪ0402 ｨ 0205ｨｺｨｨ 01ｨｨ09ｨｨ0906ｨｬ04, ｨｮｨｺｨ 04ｨ ｨｪｨｪ0402 ｨｪｨ 08ｨｨ09ｨｮｨｪｨｺ02, ｨｰｨ ｨｺ ﾂ02ｨｪ ｨｬ0604ｨ ｨｨｨｺｨｮ03 ｨ ｨｺ-ｨ 0205ｨｺ ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨｨｦ. 02ｨｪｨｨ, ｨｰｨｪ06, 06ｨ ﾂｨｨ09ｨ 06ｨｰ ｨｺ ｨｨｨｪｨ 02ｨｨ ｨｨｨｪｨｰ0204ｨ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ ｨｰ04, ｨｨｨｪ09ｨ 00ｨｨｨｪｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 09ｨｰ02ｨｪｨｺｨｨ ｨｨ 02ｨｨｨｰ060705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ ｨ ｨｰｨｨ02 Z-ｨｺ0605ｨｹ02ｨ 0308ｨｨ ｨｰ06ｨｬ ﾂｨｰ06 ｨｪ0206ｨ ｨｨｨｬ0609ｨｰｨｹ FtsZ ｨ 02ｨｨｨｰ06ｨｺｨｨｨｪ0204ｨ ｨｮ09ｨｰｨ ｨｪ ｨｪｨ, ｨｪ020709ｨｪ06, 0905ｨｮ03ｨｨｨｰ Z-ｨｺ0605ｨｹ0206 ｨｪ ｨｰ0902ｨｪｨｪ ｨ ｨｺｨｰｨｨ09ｨｪ ｨｬ0201ｨ ｨｪｨｨ ﾂ0209ｨｺ ｨ ｨｰｨｨ07 ｨｬ02ｨｬｨ 08ｨ ｨｪ04, ｨｨ05ｨｨ ｨｹ ｨ ｨ 0909ｨｨ09ｨｪｨ (ｨｪｨ 0708ｨｨｨｬ0208, ｨｰ06ｨｨｨｰ ｨｨ ﾂ02ｨｪｨｨｨｨ ｨｬ02ｨｪｨｰ0609, 09ｨｨｨｪｨｰ0204ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ04 ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 09ｨｰ02ｨｪｨｺｨｨ) ｨｨ09ｨｺ0506 ﾂ02ｨｪ06, ﾂｨｰ06 Z-ｨｺ0605ｨｹ0206 ｨｨ0008ｨ 02ｨｰ 06ｨ 02 05ｨｰｨｨ ｨｨ ｨ 09ｨｪｨｨ02 01ｨ ｨｪｨｪ0402 ｨｮｨｺｨ ｨ 06ｨｰ ｨｪｨ ｨｰ06, ﾂｨｰ06 ｨｰ0605ｨｹｨｺ06 ｨｰ0802ｨｰｨｹ 09ｨｮｨｬｨｬｨ 08ｨｪ FtsZ ｨｺ0502ｨｰｨｺｨｨ ｨｨｨｰ ｨｰｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609 ｨｺ0605ｨｹ02ｨ. 0208ｨｮ00ｨｨ ｨｰ0802ｨｰｨｨ ｨｬ060502ｨｺｨｮ05 FtsZ, ｨｪｨ ｨｴｨｨ ｨｪ02 ｨｺ0605ｨｹ02ｨ ｨｰｨ ｨｺ0302 ﾂｨ 09ｨｰｨｨ ﾂｨｪ ｨｬ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609, 08ｨ ｨｪ ｨｺ0502ｨｰｨｺ02 ｨｪ ｨｮ ﾂｨ ｨｦｨｪ04ｨｬ 06ｨ 08ｨ 0406ｨｬ, ｨｪ06 ｨ 0409ｨｰ0806 ｨｨ ｨｪ0606ｨ 08ｨ 04ｨｪ ｨｬ02ｨｴｨ 06ｨｰ ｨｰ ｨ ｨｺ ｨｮ, 0600ｨｨｨ ｨ 07 ｨｺ0502ｨｰｨｺｨｮ ｨｨ08ｨ 05ｨｹｨｪ06ｨｬｨｮ ｨｬｨ ｨｮｨｰｨｮ ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ ｨｬｨｨｨｬ06 ｨｮ09ｨｰｨ ｨｪ ｨｪｨｪ06ｨｦ 08ｨ ｨｪ ｨｨ 09 02ｨｨｨｰ06ｨｺｨｨｨｪ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ04 FtsZ ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ 09 09ｨｰｨ ｨｪ ｨｪｨｨｨｨ ｨｨ ｨ ｨｪｨｨｨｨ ｨｬ04 ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｺ0502ｨｰｨｺｨｨ (Thanedar, Margolin, 2004). 07 E. coli 09ｨｨｨｪ010806ｨｪｨｪｨ 07 ｨｨｨｪｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 FtsZ ｨｨ 0702ｨｪｨｨ02ｨｨ0505ｨｨｨｪ ｨ 06ｨｴ ｨ 0205ｨｺｨ ｨｺｨ 08ｨ 06ｨｺ09ｨｨ070207ｨｰｨｨ01ｨ 0404 PBP5 0708ｨｨ090601ｨｨｨｰ ｨｺ 0902ｨｰ090502ｨｪｨｨ06 ｨｺ0502ｨｰ06ｨｺ (Varma, Young, 2004) ｨｪ06 ｨｪ0209ｨｺ0605ｨｹｨｺ06 ｨｬ ｨｦ 0903ｨ ｨｰｨｨ07 Z-ｨｺ0605ｨｹ02ｨ ｨｨ04 ｨｪｨｨ ｨ ｨｪ ｨｨ09ｨ ｨｪ ｨ (Bramhill, 1997) ｨ 07 ｨｬ ｨｹ 0609ｨｪ ｨ 05ｨ 09ｨｹ ｨｪｨ 09ｨｺ0605ｨｹ0302ｨｪｨｨｨｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609 FtsZ 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ ｨｮ ｨｮ00ｨ ｨｬ06ｨｴｨｹ06 ｨｪ02ｨｺ ｨｬ06ｨｰ0608ｨｪ ｨ 0205ｨｺｨ ｨｪｨ ｨ ｨｨ02 ｨｬｨｨ0604ｨｨｨｪｨ. 02ｨｪｨ ｨｪｨｨ ｨｪ02 06ｨ 09ｨｮ0301ｨ 02ｨｰ ｨｰ0608ｨ 07 ｨｬ ｨｹ, ｨｺ06ｨｰ0608ｨ ｨｰｨ ｨｰ0907 ｨｪｨ ｨｨｨ ｨ 0609ｨｪ0609ｨ ｨｪｨｪ06ｨｦ, ｨ 00ｨ 02ｨｰ ｨｰ020702ｨｪｨｪｨｮ ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨ06 Z-ｨｺ0605ｨｹ02ｨ, ｨｺ06ｨｰ ｨｰｨｺ06 04ｨ 07ｨｺ060802ｨｪ06 ｨｪｨ ｨｬ02ｨｬｨ 08ｨ ｨｪ ｨｨ 0706ｨｬ06ｨｴｨｨ 0108ｨｮ00ｨｨ01, ｨｬ0600ｨ ｨｰ0205ｨｹｨｪ0401, ｨ 0205ｨｺ0609, ﾂｨｰ ｨｨ090601ｨｨｨｰ ｨｺ ｨ ｨｰｨｨ06 ｨｨ ｨ ﾂ02 ｨｬ0201ｨ ｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｨ0504 ｨｪｨ ｨｬ02ｨｬｨ 08ｨ ｨｪｨｮ ｨｬ0603ｨｪ ｨｰｨ 05ｨｨ 05ｨｰ06ｨｦ ｨｬ ｨｨ 0903ｨ ｨｰｨｨ07 06ｨ 09ｨｮ0301ｨ 06ｨｰ0907 ｨｨ 0108ｨｮ00ｨｨｨｬｨｨ ｨ 09ｨｰ0608ｨ ｨｬｨｨ ｨｨ 09 ｨｪ060904ｨｬｨｨ ｨｪｨ ｨ ｨｪｨｨ07ｨｬｨｨ (Thanedar, Margolin, 2004) ｨｮ050702ｨｨｨｨ ｨ 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ07 Z-ｨｺ0605ｨｹ02ｨ B. subtilis ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ 02ｨｴ ｨｺ08ｨ ｨｦｨｪ02ｨｦ ｨｬ ｨ ｨ 0205ｨｺｨ ｪ FtsL ｨｨ EzrA (Kawai, Ogasawara, 2006). 0506ｨｺ08ｨ ｨｴ02ｨｪｨｨ02 Z-ｨｺ0605ｨｹ02ｨ ｨ 02ｨｰ ｨｰ020802ｨｦ 01ｨｨｨｬ FtsZ, 06ｨｰ010205ｨｹｨｪ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609 ｨｨ ｨｨ01 ﾂｨ 09ｨｰ02ｨｦ ｨｪｨｨ07 ｨｺ0502ｨｰｨｺｨｨ 06ｨｰ 09ｨｮ03ｨ 06ｨｴ ｨｺ0605ｨｹ02ｨ 06ｨｰ ｨｰ0907 ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨ 05ｨｹｨｪ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ04 FtsZ, ｨｨｨｬ0206ｨｴｨｨ02 ｨｨ040600ｨｪｨｮｨｰｨｮ06, ｨｨｨｪ060001ｨ 0907ｨｨ08ｨ ｨｨ01ｨｪｨｮ ｨｬｨｮ. 06ｨｰｨｨ 09ｨｰ08ｨｮｨｺｨｰｨｮ ｨｰｨ 06ｨｰ ﾂ0208ｨｪｨｨ01 ｨｺ0502ｨｰｨｺｨ 01 ｨｪｨ 02ｨｨｨｰ060705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ02 ｨｨ ｨ ｨｪｨｨ ｨ, ｨｺ060001ｨ Z-ｨｺ0605ｨｹ02ｨ ｨ 0605ｨｹ0302 ｨｪ02ｨｰ ｨ 09ｨｪ06 ｨｰ0802ｨｰｨｹ02ｨｦ ｨｬ ｨｨ, 0903ｨ ｨｰｨｨ ｨｮｨｴ0209ｨｰ ｨｰ0907 ｨ 05ｨ ｨ 0807 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ06 ｨｺ08ｨｨ09ｨｨ04ｨｪ04 07ｨｮ ﾂｨｺｨ ｨｰ0600ｨｨ05ｨ ｨｬ02ｨｪｨｰ0609 FtsZ ｨｰ09ｨｨ02 ｨｺ06ｨｪ000608ｨｬｨ 02ｨｨ06ｨｪｨｪ , ｨｺ06ｨｰ ｨｨ ｨｰ 0708ｨｨ 00ｨｨ ｨｨ ｨｨｨ ｨｨ ｨ ｨｪｨｨｨｨ ｨｪ ｨ ｨｪｨｨ ﾂ0209ｨｺ ｨ ｨｰｨ (Lu et al., 2000). 02ｨ 09ｨｮ0301ｨ 02ｨｰ0907 ｨｨ ｨ 05ｨｹｨｰ0208ｨｪｨ ｨｰｨｨ09ｨｪｨ ｨｬ0603ｨｪ0609ｨｰｨｹ 07ｨ 0909ｨｨ09ｨｪ ｨ ｨｰｨｨ07 Z-ｨｺ0605ｨｹ02ｨ ｨｨｨｪ09ｨ 00ｨｨｨｪｨ 02ｨｨｨｨ 09ｨｰ02ｨｪｨｺｨｨ ｨｰ04, ｨｺ06ｨｰ0608ｨ 07 06ｨ ﾂｨｨ09ｨ 02ｨｰ0907 ｨｰ08ｨ ｨｪ ｨｰｨｨ01ｨ 0406ｨｦ FtsI, ｨ ｨｪｨｪ06ｨｦ 09 FtsZ ｨｨ 0108ｨｮ00ｨｨｨｬｨｨ ｨ 0205ｨｺｨ ｨｬｨｨ, ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｴｨｨｨｬｨｨ 09 06ｨ 08ｨ ｨ ｨｪｨｨｨｨ ｨｰ04 (Margolin, 2005) ｨｰ06ｨｬ 0905ｨｮ ﾂｨ 02 FtsZ ｨｮ02ｨｰ 08ｨ 0909ｨｬｨ ｨｰ08ｨｨ09ｨ ｨｰｨｹ 09 ｨｺｨ ﾂ0209ｨｰ0902 ｨｪ02 ｨｺ0506 ﾂ ｨ 0205ｨｺｨ ｨｪｨｨ07, ｨ 05ｨｨ03ｨｹ ｨｬｨ 08ｨｺ0208ｨｪ ｨ 0205ｨｺｨ, ｨｴ ｨ ｨｮ ｨｪｨｨ07 ｨｺ0502ｨｰｨｺｨｨ ｨｨ ｨｺｨ 06ｨｴ ｨｰｨ 05ｨｹｨｪ0402 ｨ 0205ｨｺｨｨ ｨｪｨｨ ｨｨｨｰ06ｨｺｨｨｨｪ0204ｨ. 0201ｨｪｨ ｨｺ06 ｨｪｨ 05ｨｨ ﾂｨｨ02 ｨ 0205ｨｺｨ FtsZ ｨｮ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ09ｨ ｨｬｨｨｨｺ060705ｨ 04ｨｬ, ｨ ｨｪｨｨ04ｨｬ0609, ｨｮ ｨｺ06ｨｰ ｨｺ0502ｨｰ06 ﾂｨｪｨ 07 09ｨｰ02ｨｪｨｺｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｮ02ｨｰ ｨｨ ｨｪ02 ｨｪｨ ｨｦ0102ｨｪ06 ｨｬｨｪ0600ｨｨ ｨｮ00ｨｨ01 ｨ 0205ｨｺ ｨｪｨｨ07, ｨｬ060302ｨｰ 0905ｨｮ03ｨｨｨｰｨｹ ｨ 0800ｨｮｨｬ02ｨｪｨｰ06ｨｬ ｨｹ04ｨｮ ｨｰｨ ｨｪｨｨ ｨｨ ﾂｨｪ06ｨｦ, ｨ ｨｺｨｰｨｨ09ｨｪ06ｨｦ ｨｨ FtsZ ｨｪｨｨｨｨ ｨ ｨ ｨｺｨｰ0208ｨｨｨｦ. 05ｨ ｨｺ0506 ﾂ02ｨｪｨｨ ｨｪｨｨ02 ｨ ｨ ｨｺｨｰ0208ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｺ0502ｨｰｨｺｨｨ ｨｪｨ ﾂｨｨｨｪｨ 02ｨｰ ｨ 08ｨ ｨ ｨｪｨｨ07 ｨｰｨ ｨｺ ｨｪｨ ｨ 02ｨｬ06ｨｦ 01ｨｨ09ｨｨ0906ｨｬ04, 0609ｨｪ0609ｨｮ ｨｺ06ｨｰ060806ｨｦ ｨｰｨ ｨｰ ｨｺ0605ｨｹ ｨ ｨｰｨｨ07, ｨｨ05ｨｨ Z-ｨｺ0605ｨｹ0206, ｨ 06ｨｴ0202 ｨｺ0502ｨｰｨｺｨｮ 0708ｨｨｨｬ0208ｨｪ ｨｨｨｪ ｨｹ ｨｰｨ ｨｰ 0906-