SHAPS YJEXPANDS 2SHAPS YJEXPANDS 2 3SHAPS YJEXPANDS 2 Depression Inventory DSM DSMR Montgomery Åsberg Depression Rating

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1 1135 特集認知症 (AD,DLB) およびパーキンソン病における認知障害と抑うつ症状 1 2 QOL 1030 SHAPS SHAPS 索引用語 SnaithHamilton Pleasure Scale SHAPS はじめに QOL 1 Syndrome Subtype Prevalence Depression Major depression 1030 Minor depression 1020 Anxiety All 3040 Panic 430 Psychosis Hallucinations 4050 Delusions 510 Apathy 1770 Fatigue Ⅰ. うつの頻度 Aarsland DSM ICD10 Montgomery A sberg Depression Rating Scale Beck 1 2

2 SHAPS YJEXPANDS 2SHAPS YJEXPANDS 2 3SHAPS YJEXPANDS 2 Depression Inventory DSM DSMR Montgomery Åsberg Depression Rating Scale Beck Depression Inventory MMSE Ⅱ. アンヘドニア Chapman Scales for Physical and Social Anhedonia SnaithHamilton Pleasure ScaleSHAPS 2 SHAPSJ The Young Japanese Expert Group for Parkinsons D i s e a s e a n d M o v e m e n t D i s o r d e r sy J

3 1137 2SnaithHamilton Pleasure ScaleSHAPS EXPANDS SHAPSJ SHAPS SHAPS SHAPS Hohen Yahr stage SHAPS A10SHAPS

4 SHAPSJ p NS SHAPSJ NS NS HoehnYahr stage YJEXPANDS 4 10 odds 2,4,68,11,1416 odds 95 Ⅲ. うつはパーキンソン病の前駆症状か?

5 odds 95 p Behari 2 Taylor 14 McCann 8 Hubble 4 PD PD PD PD ,4,8, PD 45 peak hydroxyindoleacetic acid 5 3 おわりに QOL

6 cases controls 文 1Aarsland, D., Marsh, L., Schrag, A.Neuropsychiatric symptoms in Parkinsons disease. Mov Disord, , Behari, M., Srivastava, A.K., Das, R.R., et al. Risk factors of Parkinsons disease in Indian patients. J Neurol Sci, , Braak, H., Del Tredici, K., Bratzke, H., et al.staging of the intracerebral inclusion body pathology associated with idiopathic Parkinsons diseasepreclinical and clinical stages. J Neurol, 249Suppl. 315, Hubble, J.P., Cao, T, Hassanein, R.E.S., et al. Risk factors for Parkinsons disease. Neurology, , Kostic, V.S., Djuricic, B.M., CovickovicSternic, N., et al.depression and Parkinsons diseasepossible role of serotonergic mechanisms. J Neurol, , 献 Lauterbach, E.C., Freeman, A., Vogel, R.L.Differential DSM psychiatric disorder prevalence profiles in dystonia and Parkinsons disease. J Neuropsychiatry Clin Neurosci, , Leentjens, A.F., Van den Akker, M., Metsemakers, J.F., et al.higher incidence of depression preceding the onset of Parkinsons diseasea register study. Mov Disord, , McCann, S.J., LeCouteur, D.G., Green, A.C., et al.the epidemiology of Parkinsons disease in an Australian population. Neuroepidemiology, , Nagayama, H., Kubo, S., Hatano, T., et al.validity and reliability assessment of a Japanese version of the SnaithHamilton Pleasure Scale. Intern Med, , Parkinson Schuurman, A.G., van den Akker, M., Ensinck, K. T., et al.increased risk of Parkinsons disease after depressiona retrospective cohort study. Neurology, , Shiba, M., Bower, J.H., Maraganore D.M., et al. Anxiety disorders and depressive disorders preceding Parkinsons diseasea casecontrol study. Mov Disord, , Tandberg, E., Larsen, J.P., Aarsland, D., et al. The occurrence of depression in parkinsons disease. A communitybased study. Arch Neurol, , Taylor, M.H., SaintHilaire, L.A., Cupples, C.A., et al.environmental, medical, and family history risk factors for Parkinsons diseasea New Englandbased case control study. Am J Med Genet, , Van Den Eeden, S.K., Tanner, C.M., Popat, R.A., et al.the risk of Parkinsons disease associated with head injury and depressiona populationbased case control study. Neurology, 54Suppl. 3347, Yang, J., Wu, Z., Lou, X.A casecontrol study on risk factors in etiology of Parkinsons disease. Zhonghua Liu Xing Bing Xue Za Zhi, 1569, 1994

7 Powered by TCPDF ( Depression in Parkinson s Disease Shin KITAMURA 1, Hiroshi NAGAYAMA 2 1Department of Neurology, Nippon Medical School Musashikosugi Hospital 2Department of Neurology, Nippon Medical School Depression affects Parkinsons diseasepdpatients QOL. Although it changes with the diagnostic criteria used, the frequency of depression in PD is approximately Anhedonia is characteristic in PD. According to research on anhedonia in PD using the SnaithHamilton Pleasure ScaleSHAPS, the positive ratio of anhedonia is high in PD. The SHAPS score significantly correlates with the severity of PD and duration of the disease. An examination of the literature on depression before the development of motor symptoms of PD revealed that the risk of PD is high in patients with a history of depression. Pathologically, the substantia nigra is affected in the later stages and raphe nuclei are affected in the early stages. This suggests that depression is a prodromal symptom of PD. Authors abstract Keywords Parkinsons disease, depression, anhedonia, SnaithHamilton Pleasure Scale SHAPS

Vol.0 No. 0 図 Montreal Cognitive AssessmentMoCA orientation visuospatial attention orientation 4 visuospatial executive MMSE MoCA language language me

Vol.0 No. 0 図 Montreal Cognitive AssessmentMoCA orientation visuospatial attention orientation 4 visuospatial executive MMSE MoCA language language me Parkinson 病の認知機能障害を MMSE と MoCA により評価した多施設共同研究 : 慶應 PD データベース Cognitive impairment in Parkinson s disease patients evaluated by the Montreal Cognitive Assessment and the Mini-Mental State Examination.