HISTOCHEMISTRY OF THE RAT PROSTATIC GLAND II INFLUENCES OF THE PINEAL BODY, SALIVARY GLANDS, ALLOXAN DIABETES, VITAMIN B2 DEFICIENCY, LIGATION OF THE

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1 Title ラット前立腺の組織化学 2: 松果体, 唾液腺, 糖尿病,Vit- B2 欠乏症及び精管結紮, 肝臓障碍の影響 Author(s) 福重, 満 Citation 泌尿器科紀要 (1965), 11(12): Issue Date URL Right Type Departmental Bulletin Paper Textversion publisher Kyoto University

2 HISTOCHEMISTRY OF THE RAT PROSTATIC GLAND II INFLUENCES OF THE PINEAL BODY, SALIVARY GLANDS, ALLOXAN DIABETES, VITAMIN B2 DEFICIENCY, LIGATION OF THE SEMINAL DUCTS AND LIVER DAMAGES Mitsuru FUKUSHIGE From the Department of Urology, Hiroshima University School of Medicine (Director : Prof. T. Kato, M. D.) Using Wistar-stain male rats, histochemical studies were made on influences of the pineal body, salivary glands, alloxan diabetes, Vit. B2 deficiency, ligation of the seminal ducts and liver damages upon the sexual glands and adrenal glands with a focusing of prostatic gland. 1) In one month after extirpation of the pineal body, weight and stainabilities of the adnexal, testicular and adrenal glands well sustained or increased with an evidence of hyperfunction. 2) Extirpation of the both parotid glands resulted decreases in weight and function of the adnexal glands, testicle and adrenal glands. Extirpation of the submaxillay gland resulted less influence in these organs except for slight decrease in SD activity of the prostatic gland and seminal vesicle. Administration of Parotin at the dose of 0.25 mg three times a week showed a more pronounced accerelative effects on weight and functions of the adnexal glands and testicles than that of at the dose of 0.25 mg once a week. Adrenal function was also increased. 3) In rats with alloxan diabetes, decreases in weight of the adnexal glands and activities of SD and Zn of the prostatic gland and seminal vesicle were demonstrated, of which grades progressively advanced with elapse of time. Spermatogenic function of the testicles was suppressed and weight and stainabilities of the adrenal glands were decreased. 4) In vitamen B2 deficiency, although weight and stainabilities of sexual organs were decreased, Zn stain was only turned to the better in the prostatic gland. 5) In 2 months aften ligation of the seminal ducts, decrease in prostatic function was only slightly demonstrated as well as decrease in weight and stainabilities of the testicle. 6) With administration of carbon-tetrachloride, weight of the testicles did not decrease too much although decrease in weight of the prostatic gland was rather pronounced. Marked decreases in RNA, Zn and SD in the prostatic gland, decreases in SD in the seminal vesicle and 17 KS in the adrenal glands were also recognized. Administration of

3 sexual hormones and experimentally produced thyroid dysfunctions resulted rather marked responses to the adnexal organs. Prostatic Zn content always decreased accompanied by damaged liver.

福重:ラット前立腺の組織化学H Wschr,,29:670,1951. 1215 1934. 64)山田;日 65)横田:Arch.Jap.Chirur.,28:432,1959. 67)DelCastillo:38)よ内分泌雑誌.34 :358,1958. 68)永田り引用.

14 福重:ラット前立腺の組織化学H Wschr,,29:670, )山田;日 65)横田:Arch.Jap.Chirur.,28:432, )DelCastillo:38)よ内分泌雑誌.34 :358, )永田り引用. 山下=日内分泌雑誌,33:440, )Zondek:Skand.Arch.Physio1.,70:132, (1965年7月12日. 受付) 羅灘リリ逗い'卜.議果体別後1カ月 ACP( )前立腺曜1騒糟 "撫駕_ 写真1松墜..筆' ジ "一騰写真IV耳顎下腺別1ヵ月 SD( )精嚢暇瑠触塗写真H松果体易IS+TP投与1カ月 Zn(粘)前立腺写真V顎下腺別1カ月 ALP(+)前立腺 ii' 罵こ凝灘i 写真皿松果体別+Eb投与1カ月 ALP(=)睾丸懸 kr ", }で}' 1 [v - " G 蝉シ,!ρ パA ρ 鱗隅'.1設.!. 繍 {彊 1 J :s, じ' 縷灘雛写真V工Parotin週3回, ACP(夢)睾 1カ月丸

15 1216 福重:ラット前立腺め組織化学H 購灘鵜醐篠魯鰻写真孤Alloxan糖 ACP( )睾尿病2週丸戸慣夢璽9琴 '獅懸叢1 写真XCC14 HE.脂投与2週肪変性.肝臓?ra: 鞭灘灘雛. 灘難磁. 張%.犠ま懸照麓輩蹴野ムゆ ' 鴫蝿為ゴド艘縄考濯露懸' 斡羅,瀞落灘騨卿 P., 窒薪写環灘灘灘醗緊騨蓼写真1皿B2敏乏症2ヵ月 RNA( )前立腺綴写真IX精管結紮後2カ月 RNA( )睾丸写真X五CCI,投与4週 Z4( )前立腺雪ノ奪, る喚で ;. 醜r 齪雛1辮写真)皿CCI4十Tp投 SD(夢)前与4週立腺

Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date URL

Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date 1958-01 URL http://hdl.handle.net/2433/111559 Right Type Departmental Bulletin