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1 % % % high turnover D low turnover cortical bone 64 No.29 November 24

2 Technical Reports cancellous bone 1 X CT Quantitative Computed Tomography, QCT 2 2 Sound Of Speed, SOS χ [m] t [s] c 1 K 2 ρ K 2 X Dual energy X-ray Absorption, DXA 2 X 2 SOS BUA 65

3 Broadband Ultrasound Attenuation, BUA.1 MHz 2 MHz P P 3 a P P Attenuation [db] 3.1 MHz 2 MHz 3 b BUA[dB/MHz] 4 BUA.1 1 SOS BUA mm 2 SOS BUA BUA 2 SOS22 27 m/s 15 m/s 66 No.29 November 24

4 Technical Reports BUA MHz X QCT BUA BUA 6 a BUA BUA 67

5 in vivo SOS BUA 15 7 Quality of Life 7 68 No.29 November 24

6 Technical Reports 1 : 1, 1, Consensus Development of Conference: Diagnosis, prophylaxis and treatment of osteoporosis, The American Journal of Medicine, 94, ,,, 13, C. M. Langton, S. B. Palmer and R. W. Porter, The measurement of broadband ultrasonic attenuation in cancellous bone, Engineering in Medicine, 13, 89-91, MEP Ltd A. Hosokawa and T. Otani, Ultrasonic wave propagation in bovine cancellous bone, Journal of the Acoustical Society of America, 11, A. Hosokawa, T. Otani, T. Suzaki, Y. Kubo and S. Takai, Influence of Trabecular Structure on Ultrasonic Wave Propagation in Bovine Cancellous Bone, Japanese Journal of Applied Physics, 36, Pt. 1, A. Hosokawa and T. Otani, Acoustical anisotropy in bovine cancellous bone, Journal of the Acoustical Society of America, 13, Pt. 1, ,, Osteoporosis Japan, 11, ,, US23-95, T. J. Haire and C. M. Langton, Biot Theory: A Review of Its Application to Ultrasound Propagation Through Cancellous Bone, Bone, 24, , Elsevier Science Inc E. R. Hughes, T. G. Leighton, G. W. Petley and P. R. White, Ultrasonic propagation in cancellous bone: A new stratified model, Ultrasound in Medicine and Biology, 25, , Elsevier Science Inc T. Otani, R. Takatsu and S. Tanaka, Modelization of acoustic path of cancellous bone and quantitative estimation of bone density, Proceedings of Ultrasonics World Congress 23, , ISBN , Societe Francaise d Acoustique L. Cardoso, A. Meunier and C. Oddou, Theoretical and experimental ultrasonic characterization of anisotropic properties in cancellous bone, Proceedings of Ultrasonics World Congress 23, , ISBN , Societe Francaise d Acoustique R. Barkmann, W. Timm, R. Scheffzcyk, E-M. Lochmuller and C-C. Gluer, Fast wave propagation in the epiphysis of human finger phalanges-associations between ultrasound variables and structure of trabecular bone, Proceedings of Ultrasonics World Congress 23, , ISBN , Societe Francaise d Acoustique P. H. F. Nicholson, Quantitative ultrasound of bone: Myth and reality, Proceedings of Ultrasonics World Congress 23, , ISBN , Societe Francaise d Acoustique 23. Hiroki Nagaoka Takuji Suzaki Takahiko Otani, DSc. Isao Mano Kaoru Horii 69

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