日本化学療法学会雑誌第57巻第5号

Size: px
Start display at page:

Download "日本化学療法学会雑誌第57巻第5号"

Transcription

1 in vitro Key words Streptococcus pneumoniae β Haemophilus influenzae Escherichia coli I

2 Table. Antibacteriallevofloxacinactivityagainstclinicalisolates Organism Year Susceptibility(%)(Numberofstrains) MIC(μ g/ml) MSSA.(36) 6.().3(76).(,6)... MRSA 7.3(3).6().(7).3(,6) > > > 6 > 6 MSCNS.(7).().(37) (7) MRCNS 3.3(7).3(3) 6.(6) 3.(,) > Streptococcuspneumoniae ().(3).().(,) Streptococcuspyogenes (7) (33).(36).(676) Enterococcusfaecalis 7.(3) 7.(7) 7.(6) 6.(7) > Enterococcusfaecium.3().(37).6().3(663) > > 6 6 Haemophilusinfluenzae () ().(67).(,) <_.6 <_.6 <_. <_. Neiseriagonorhoeae.(7).3() 6 6 Moraxela(Branhamela)catarhalis (73) ().(3) (76) <_.6 <_ Escherichiacoli 6.7(363).().(66).(,). Klebsielapneumoniae.(3).().(63).(,). <_.6.. Salmonelaspp. () (6) (6).(3) <_.6 <_.6 <_.6. Proteusmirabilis.(67).6(7).(373).(677) Indole-positiveProteusgroup 3.().(3).(63).3(76) Seratiamarcescens.3(33) 3.() 3.(6) 6.() Citrobacterspp..().(3).6(7).7(7) Enterobacterspp. 6.6() 7.(6) 7.(6) 6.(,) Acinetobacterspp..() 3.(3).7(7).3(3) PseudomonasaeruginosaUTI.() 6.(3) 6.(3) 6.7(3) > PseudomonasaeruginosaRTI.().(6).().(,) in vitro II LVFX Staphylococcus aureus S. pneumoniae Streptococcus pyogenes H. influenzae Moraxella Branhamella catarrhalise. coli Proteus mirabilis E. coli P. mirabilis S. pneumoniae

3 Table. LevofloxacinpharmacokineticandPK-PDparametersforS.pneumoniaecalculatedbyMonteCarlosimulation Parameter Statistics mg /day Pharmacokinetic Cmax (μ g/ml) AUCh (μ g h/ml) PK-PD Cmax/MIC AUCh/MIC median 6. (thandthpercentiles) (3.3,.) median 6. (thandthpercentiles) (3.6,3.3) median.3 (thandthpercentiles) (.,.) median 7. (thandthpercentiles) (.,37.7) PercentageofsubjectswhosePK-PDparametersreachedthetarget Cmax/MIC>_ (%) 3. AUCh/MIC>_ 3 (%). mg 3/day. (.3,3.). (3.,7.) 3.3 (.6,.) 76. (3.,.) 3.. gyra gyrb parc pare S. pneumoniae S. pneumoniae In vitro S. pneumoniae E. coli E. coli S. pneumoniae E. coli

4 Log CFU/mL Time (h) Fig.A. BactericidalactivityoflevofloxacinagainstStrepto coccuspneumoniaeclinicalisolate(eg3)inaninvi tropharmacokineticmodel. Opencircles,mgt.i.d.;closeddiamonds,mgq.d.; solidline,growthcontrol,dotedline;detectionlimit Time (h) Fig.C. BactericidalactivityoflevofloxacinagainstEscheri chiacoliclinicalisolate(gk)inaninvitropharma cokineticmodel. Opencircles,mgt.i.d.;dotedlinewithasterisks, mgq.d.;closeddiamonds,mgq.d.;solidline,growth control. III Log CFU/mL Levofloxacin ( g/ml) Fig.B. FrequencyofresistantpopulationinStreptococcus pneumoniaeclinicalisolate(eg3)aftersimulating serum concentrationoflevofloxacin. Opencircles,mgt.i.d.;closeddiamonds,mgq.d.; solidline,controlwithnodrugtreatment,dotedline;de tectionlimit Levofloxacin ( g/ml) Fig.D. Frequencyofresistantpopulation in Escherichia coliclinicalisolate(gk)aftersimulatingserum con centrationoflevofloxacin. Opencircles,mgt.i.d.;dotedlinewithasterisks, mgq.d.;closeddiamonds,mgq.d.;solidline,control withnodrugtreatment,dotedline;detectionlimit. µ

5 Table3. Pharmacokineticlevofloxacinparametersin(A)single-doseand(B)multiple-dosestudies (A)Single-dosestudy Dose (mg) n Cmax (μ g/ml) tmax (h) t/ (h) AUCinf (μ g h/ml) CLt/F (L/h) Vdz/F (L) CLr (L/h) Chinese , (B)Multiple-dosestudy n Day Cmax (μ g/ml) Ch (μ g/ml) tmax (h) t/ (h) AUCh (μ g h/ml) Vdz/F (L) CLss/F (L/h) CLr (L/h) nonelderly elderly µ µ µ S. pneumoniae H. influenzae MBcatarrhalis E. coli Enterococcus faecalis Klebsiella pneumoniae Pseudomonas aeruginosa

6 Table. Pharmacokineticlevofloxacinparametersaftersingleoraladministration(mg)tosubjects withimpairedrenalfunction Group n Cmax (μ g/ml) tmax (h) t/ (h) AUC7h (μ g h/ml) CLt/F (L/h) Vdz/F (L) CLr (L/h) I a) I b) I c) Mean± a) GroupI:Ccr>_ ml/min b) GroupI:<_ Ccr< ml/min c) Group I:Ccr< ml/min,exceptfordialysissubjects Table. Clinicaleficacyattreatmentcompletion Diagnosis Respiratorytractinfection Community-acquiredpneumonia Secondaryinfectionofchronic respiratorydiseases Acutebronchitis Urinarytractinfection ComplicatedUTI Pyelonephritis Cystitis UncomplicatedUTI Acuteuncomplicatedcystitis Acuteuncomplicatedpyelonephritis RecurentuncomplicatedUTI Eficacy(%) Chinese 36/3. 77/ / 3. 3/37 7. /. 3/ 7. /. 3/7 3. 3/ 6. 3/7 3. 6/ 66.7 / 73.3 /. 37/ /6. 7/7.7 /6. S. aureus S. pneumoniae K. pneumoniae H. influenzae Haemophilus parainfluenzae E. coli K. pneumoniae P. mirabilis

7 Table6. Bacteriologicalresponse Causativebacteria Staphylococcusaureus Staphylococcuscapitis Staphylococcusepidermidis Staphylococcushaemolyticus Staphylococcussaprophyticus CNS Streptococcusagalactiae Streptococcusanginosus Streptococcuspneumoniae Streptococcussalivarius Streptococcussanguinis Streptococcusmitis β -hemolyticstreptococcus Enterococcusfaecalis Enterococcusfaecium Enterococcusavium Enterococcusdurans Enterococcusgalinarum Leuconostocspp. Gemelamorbilorum Neiseriaspp. Moraxela(Branhamela)catarhalis Escherichiacoli Citrobacterfreundi Citrobacterkoseri Klebsielapneumoniae Klebsielaoxytoca Klebsielaozaenae Enterobactercloacae Enterobacteraerogenes Seratiamarcescens Proteusmirabilis Proteusvulgaris Morganelamorgani Providenciaretgeri Providenciaalcalifaciens Pantoeaagglomerans Enterobacteriaceae Haemophilusinfluenzae Haemophilusparainfluenzae Haemophilusspp. Pseudomonasaeruginosa Burkholderiacepacia Stenotrophomonasmaltophilia Acinetobactercalcoaceticus Acinetobacterbaumanni Acinetobacterlwofi Acinetobacterjuni Acinetobacterjohnsoni Eradication(%) respiratorytractinfection urinarytractinfection Chinese Chinese / /(.) /(.) /(.) 3/3 / /(.) / / /(.) /3(.3) / / /(.7) / /(.) /(.) /(6.6) / / / /(.) 7/(7.) /6(6.7) /(.) /(.) /3 /(.) / / / / / /(.) 7/7(.) 7/7(.) /6(3.3) 6/7(6.7) 6/(.) / / / / 6/6(.) 6/6(.) 3/3(.) 3/3(.) / / /(.) /3(33.3) 3/ / / /(.) 3/3(.) / /(.) / 3/3(.) /(.) /6(3.3) / / / / /(.) 37/3(7.) 67/7() /(.) /(6.) /(.) / /(.) / 3/(.) 3/3(.) / /(.) / γ

8 Table7. Adversedrugreactions PT a) Patientsevaluatedforsafety Patientswithadversedrugreaction(%) 337 3(7.6) Chinese, 367(.) Total, 6(.) Dizziness 6(.) 3(.3) (3.7) Nausea 3(3.) (3.) (3.) Whitebloodcelcountdecreased (.6) (3.) (3.) Insomnia (.6) 3(.) 37(.3) Alanineaminotransferaseincreased 6(.) 3(.) (.) Bloodlactatedehydrogenaseincreased 6(.) 6(.6) Headache (.) (.) 3(.) Diarhoea (.) 7(.6) (.) Vomiting (3.) (.) (.) Aspartateaminotransferaseincreased (.) 7(.) (.) Eosinophilcountincreased (3.6) 7(.6) (.) Plateletcountdecreased (.) (.) Stomachdiscomfort (.) (.) (.) Anorexia (.3) (.) (.) Hepaticfunctionabnormal (.) (.) Plateletcountincreased (.) (.) Rash (.) (.7) 3(.) Neutrophilcountdecreased (.3) (.) 3(.) Asthenia (.) (.) Gamma-glutamyltransferaseincreased (.) (.) (.6) Dyspepsia (.) (.) (.3) Bloodcreatinephosphokinaseincreased (.) a) MedDRA/JV.. Table. Patientprofilesversusadversedrugreactions Patientswithadversedrugreaction(%) Patientprofiles (n= 337) Chinese(n=,) Total(n=,) Gender Male 36/ (.) 6/ (.) 7/7 (7.3) Female 7/6 (36.) 6/7 (.) 63/6 (3) Age < 6 /3 (36.) 3/,7 (.) 37/, (3.6) (yr) 6 to< 7 7/7 (7.) 6/7 (6.) 73/6 (7.) 7 to< /7 (.3) /7 (.3) / (.) / (.) Bodyweight < 3/ (7.3) / 3/ (.) (kg) to< 6 6/ (3.3) 63/7 (.) 3/77 (.) 6 to< / (.) / (3.6) /7 (.) /7 (.3) /76 (.) 3/3 (7.7) Ccr(mL/min) to< /6 (7.) /3 (3.) / (.3) (Cockcroft) to< 3/3 (.) /36 (.) 6/3 (7.) /3 (37.) 7/ (.) /7 (3) unknown /6 (66.7) /6 (66.7)

9 QTcF Male Female Age<_ Age>_ 6 QTcP QTcB QT n Table. LevofloxacinefectonQT/QTcinterval(ms) Changefrom baseline Levofloxacin Placebo Meandiference %CImaximum Diferencebetweenlevofloxacinandplacebotreatmentinchangefrom thebaselineinqt/qtcintervalattmax analyzedusingalinearmixedmodel.themodelincludestreatment,sequence,and periodasfixedefectsandsubjecttorandom efect.thetime-matchedbaselineofqtinterval, age,andgenderareincludedascovariates.qtcp= QT/RR.. IV V

10 Plasma concentration ( g/ml) Group I (Ccr 7. ml/min) mg qd (A) Time (h) Plasma concentration ( g/ml) Group II (Ccr 6. ml/min) (B) mg qd Initial dose of mg and subsequent doses of mg qd Time (h) Plasma concentration ( g/ml) Group III (Ccr.7 ml/min) (C) mg qd Initial dose of mg and subsequent doses of mg qd Initial dose of mg and subsequent doses of mg qod Time (h) Fig.. Simulatedplasmaconcentrationoflevofloxacinduring7-daytreatment. Plasmaconcentration-timeprofilesfortypicalpatientswithCcr=7.mL/min(GroupI),Ccr=6. ml/min(groupi),andccr=.7ml/min(group I).

11 In

12 in vitro

日本化学療法学会雑誌第57巻第S-2号

日本化学療法学会雑誌第57巻第S-2号 Key words β I Table. Observationandtestschedule Testschedule Observation/Tests Beforetreatment Endoftreatment 5 9days aftercompletion oftreatment 4 6weeks aftercompletion oftreatment Informedconsent Patientbackground

More information

日本化学療法学会雑誌第57巻第S-2号

日本化学療法学会雑誌第57巻第S-2号 µ µ Key words µ µ µ I Table1. Subjectprofilesin(A)singleand(B)multiple-dosestudies (A)Single-dosestudy Age (yr) Height (cm) Bodyweight (kg) BMI (kg/m ) Ccr(Cockcroft) (ml/min) Ethnicity dose(mg) n 5 5.1±.,3

More information

日本化学療法学会雑誌第58巻第4号

日本化学療法学会雑誌第58巻第4号 Escherichia coli Enterococcus faecalisstreptococcus agalactiae Klebsiella pneumoniae Staphylococcus epidermidis E. colie. faecalispseudomonas aeruginosa K. pneumoniae S. agalactiae E. coli E. coli μ p

More information

日本化学療法学会雑誌第57巻第1号

日本化学療法学会雑誌第57巻第1号 In vitro Streptococcus pneumoniae Escherichia coli in vitro Streptococcus pneumoniae Escherichia coli µs. pneumoniae E. coli µ Key words in vitrostreptococcus pneumoniae Escherichia coli Escherichia coli

More information

日本化学療法学会雑誌第61巻第6号

日本化学療法学会雑誌第61巻第6号 β Moraxella catarrhalis Escherichia coli Citrobacter Klebsiella pneumoniae Enterobacter cloacae Serratia marcescens Proteus Pseudomonas aeruginosa Acinetobacter Bacteroides fragilis β Haemophilus influenzae

More information

日本化学療法学会雑誌第64巻第4号

日本化学療法学会雑誌第64巻第4号 β β Moraxella catarrhalisescherichia colicitrobacter Klebsiella pneumoniaeenterobacter cloacaeserratia marcescens Proteus Providencia Pseudomonas aeruginosaacinetobacter Bacteroides fragilis β β E. colik.

More information

日本化学療法学会雑誌第56巻第S-1号

日本化学療法学会雑誌第56巻第S-1号 Key words Streptococcus pneumoniae µ µ H F Cl H H N N H N F COOH O Fig.1. Sitafloxacinstructure. I γ S. pneumoniae Haemophilus influenzae Table1. Observationandtestschedule Observation/Tests Informedconsent

More information

- 1 -

- 1 - - 1 - - 1 - ... 1... 2... 4... 5... 9... 11... 14... 16... 20... 21... 22... 23... 23 - 1 - - 2 - - 3 - - 4 - - 5 - - 6 - - 7 - - 8 - - 9 - ( ) - 10 - - 11 - Pseudomonas aeruginosa Escherichia coli Staphylococcus

More information

日本化学療法学会雑誌第57巻第6号

日本化学療法学会雑誌第57巻第6号 Streptococcus pneumoniae Haemophilus influenzae Moraxella catarrhalis S. pneumoniae S. pneumoniae β β H. influenzae S. pneumoniae H. influenzae M. catarrhalis Key words Otalgia Fever Item Crying,Iritation,

More information

日本化学療法学会雑誌第56巻第1号

日本化学療法学会雑誌第56巻第1号 β β β β β Streptococcus pneumoniaehaemophilus influenzaemoraxella catarrhalismycoplasma pneumoniaechlamydia pneumoniae β Key wordsβ mys nilc laci ngis Table. Assessmentschedule Parameters Patientcharacteristics

More information

日本化学療法学会雑誌第55巻第S-1号

日本化学療法学会雑誌第55巻第S-1号 µ µ Key words Streptococcus pneu- moniae S. pneumoniae µ µ I γ H H C HN F F O N O CO H H C SO H H O Fig.. ChemicalstructureofGRNX. γ γ II Haemophilus influenzae Pseudomonas aeruginosa Streptococcus intermedius

More information

日本化学療法学会雑誌第57巻第4号

日本化学療法学会雑誌第57巻第4号 Streptococcus pneumoniae Haemophilus influenzae β β Key words I β Enterococcus faecium Pseudomonas aeruginosa Streptococcus pneumoniae S. pneumoniae Haemophilus influenzae S. pneumoniae H. influenzae Table.

More information

日本化学療法学会雑誌第54巻第S-1号

日本化学療法学会雑誌第54巻第S-1号 β β β Key words β β I HP- -CD CHR RHC R R R R CHR R R R R RHC R R R CHR R R R RHC CHR R H CH CH Fig.. Structuralformulaofhydroxypropyl-β -cyclodextrin(hp-β -CD). CH n H β β β β Table-. Dosageandadministration(Singleadministrationstudy)

More information

日本化学療法学会雑誌第59巻第5号

日本化学療法学会雑誌第59巻第5号 Streptococcus pneumoniae Haemophilus influenzae Moraxella catarrhalis S. pneumoniae H. influenzae M. catarrhalis S. pneumoniae H. influenzae M. catarrhalis S. pneumoniae H. influenzae M. catarrhalis S.

More information

R06_01

R06_01 Staphylococcus aureus (MSSA) PCG (N=118,334) 57,369 (48.5%) 判定不能 :3 (0.0%) 60,962 (51.5%) CEZ (N=143,723) I:42 (0.0%) 143,635 (99.9%) R:46 (0.0%) CVA/AMPC (N=19,281) R:14 (0.1%) 19,265 (99.9%) 判定不能 :2

More information

MIC MIC...

MIC MIC... 50 mg 10% 2.7.36 2.7.36 2.7.36... 1 1.6... 1 2.6... 3 3.6... 5 3.16... 5 3.26... 12 3.36... 16 4.6... 17 5.6... 19 6.6... 20 2.7.3.3.16-1 MIC... 9 2.7.3.3.16-2 MIC... 10 2.7.3.3.16-3 MIC E. coli... 11

More information

日本化学療法学会雑誌第65巻第3号

日本化学療法学会雑誌第65巻第3号 μ Key words Chlamydia trachomatis C. trachomatis I Table1.Observation items, categories and scores Observation item Category Score Body temperature () Lower abdominal pain Uterine corpus tenderness Condition

More information

内科96巻3号★/NAI3‐1(第22回試験問題)

内科96巻3号★/NAI3‐1(第22回試験問題) µ µ α µ µ µ µ µ µ β β α γ µ Enterococcus faecalis Escherichia coli Legionella pneumophila Pseudomonas aeruginosa Streptococcus viridans α β 正解表正解記号問題 No. 正解記号問題 No. e(4.5) 26 e 1 a(1.2) 27 a 2

More information

2.7 臨床概要

2.7 臨床概要 2.7 臨床概要 A/G Al-P ALT AST AT- AUC AZM BIPM BP BUN CEZ CFPN-PI CFU CLcr Cmax CNS COPD CPFX CRP CS CYP CVA DBT DHP-I DIC DRPM DRPM-DC FAS γ-gtp GCP GNB GNF-GNR GPB HAM - Staphylococcus C P450 -I Full Analysis

More information

1.Streptococcus pneumoniae, Streptococcus pyogenes JC-1,S.aureus Smith,methicillin (DMPPC)- susceptible S. aureus subsp. aureus (MSSA) TR101, DMPPC-resistant S. aureus subsp. aureus (MRSA) TR102, Staphylococcus

More information

日本化学療法学会雑誌第60巻第4号

日本化学療法学会雑誌第60巻第4号 Streptococcus pneumoniae Haemophilus influenzae S. pneumoniae H. influenzae Key words β Streptococcus pneumoniae Haemophilus influenzae S. pneumoniae H. influenzae μ μ S. pneumoniae H. influenzae S. pneumoniae

More information

CHEMOTHERAPY Methicillin-resistant S.aureus(MRSA) coccus epidermidis 105 Streptococcus pyogenes E.faecali senterococcus avium Enterococcus faecium Str

CHEMOTHERAPY Methicillin-resistant S.aureus(MRSA) coccus epidermidis 105 Streptococcus pyogenes E.faecali senterococcus avium Enterococcus faecium Str cefaclor(ccl),cefuroxime(cxm),cefixime (CFIX),cefteram(CFTM),cefdinir(CFDN) pneumoniae,streptococcus pyogenes Moraxella catarrhalis,haemophilus influenzae,escherichia coli, Klebsiella pneumoniae,proteus

More information

2 2 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 1 Feb Neisseria gonorrhoeae ceftriaxone CTRX % 2010 CTRX 20 FQ staphylococci, E. faecium, N.

2 2 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 1 Feb Neisseria gonorrhoeae ceftriaxone CTRX % 2010 CTRX 20 FQ staphylococci, E. faecium, N. Feb. 2016 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 1 1 1 2013 69 11,762 2015 11 16 1994 2013 69 19 11,762 FQ 33 Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae

More information

CHEMOTHERAPY

CHEMOTHERAPY CHEMOTHERAPY VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin CHEMOTHERAPY AUG. 1993 VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin Table 1. Comparative in vitro activity of teicoplanin

More information

ヒビスコール液A カタログ

ヒビスコール液A カタログ 1 2 3 2002 10 Centers for Disease Control and Prevention CDC A 1. 2. 0.2% 3. 1 A 2 3 4 5 6 7 1 1 1. 2. 3. 2 1. 1 0.2% 10 Pseudomonas aeruginosa ATCC 27853 20 20 Proteus vulgaris ATCC 13315 30 20 Escherichia

More information

CHEMOTHERAPY aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Prote

CHEMOTHERAPY aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Prote aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Proteus mirabilis 3.13, Proteus vulgaris 1.56, Citrobacter freundii 0.39,

More information

THE JAPANESE JOURNAL OF ANTIBIOTICS 63 13 243 ( 37 ) 2007 12 2008 5 19 863 methicillin-susceptible Staphylococcus aureus (MSSA) Escherichia coli levof

THE JAPANESE JOURNAL OF ANTIBIOTICS 63 13 243 ( 37 ) 2007 12 2008 5 19 863 methicillin-susceptible Staphylococcus aureus (MSSA) Escherichia coli levof 242 ( 36 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 63 _ 3 prulifloxacin * ** ** CMC * ** 2010 2 22 Prulifloxacin ulifloxacin (UFX) 3 1 2003 12 2004 5 19 534 2 2005 12 2006 5 19 805 3 THE JAPANESE JOURNAL OF

More information

366 12 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 1 8 DNA 2,3 16 12 20 171 2008 12 2010 11 2 3,558 4.44% 1.65% 1.17% 90% 9 Escherichia coli -

366 12 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 1 8 DNA 2,3 16 12 20 171 2008 12 2010 11 2 3,558 4.44% 1.65% 1.17% 90% 9 Escherichia coli - Dec. 2012 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 365 11 sita oxacin 1 1 1 1 1 1 2 2 3 3 1 1 1 2 3 2012 9 14 sita oxacin STFX 50 mg 10% 2008 1 2008 12 2010 11 2 STFX 1,452 91.4% 1,235/1,351 95.9% 466/486

More information

CHEMOTHERAPY APRIL 1992 Acinetobacter calcoaceticus Staphylococcus aureus, Escherichia coli P. aeruginosa E. eoli, Klebsiella pneumoniae Serratia marc

CHEMOTHERAPY APRIL 1992 Acinetobacter calcoaceticus Staphylococcus aureus, Escherichia coli P. aeruginosa E. eoli, Klebsiella pneumoniae Serratia marc APRIL 1992 Acinetobacter calcoaceticus Staphylococcus aureus, Escherichia coli P. aeruginosa E. eoli, Klebsiella pneumoniae Serratia marcescens P. aeruginosa P. aeruginosa Streptococcus pyogenes Streptococcus

More information

Streptococcus pneumoniae,streptococcus pyogenes,streptococcus agalactiae,neisseria gonorrhoeae,h.influenzae,moraxella subgenus Branhamella catarrharis

Streptococcus pneumoniae,streptococcus pyogenes,streptococcus agalactiae,neisseria gonorrhoeae,h.influenzae,moraxella subgenus Branhamella catarrharis Streptococcus pneumoniae,streptococcus pyogenes,streptococcus agalactiae,neisseria gonorrhoeae,h.influenzae,moraxella subgenus Branhamella catarrharis, E.coil,Klebsiella pneumoniae,klebsiella oxytoca,proteus

More information

Fig.1 Chemical structure of BAY o 9867

Fig.1 Chemical structure of BAY o 9867 Fig.1 Chemical structure of BAY o 9867 CHEMOTHERAPY 43 Table 3 Antibacterial spectrum of gram negative bacteria Medium:Heart infusion agar (Nissui) Method:Agar dilution (Streak) CHEMOTHERAPY DEC 1985

More information

Feb THE JAPANESE JOURNAL OF ANTIBIOTICS ,4 2,4 2,4 2,3,4 2,3,4 2,3, ,3, Garenoxacin GRNX Levofloxacin LV

Feb THE JAPANESE JOURNAL OF ANTIBIOTICS ,4 2,4 2,4 2,3,4 2,3,4 2,3, ,3, Garenoxacin GRNX Levofloxacin LV Feb. 2016 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 1 27 27 1,4 2,4 2,4 2,3,4 2,3,4 2,3,4 2 1 2,3,4 1 2 3 4 2015 10 21 9 Garenoxacin GRNX Levofloxacin LVFX Sitafloxacin STFX Moxifloxacin MFLX Pharmacokinetics-Pharmacodynamics

More information

THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 June 2014 STFX mg mg mg mg mg 1

THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 June 2014 STFX mg mg mg mg mg 1 June 2014 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 175 29 1 2 2 2 2 2 3 4 4 5 5 2 2 1 2 3 4 5 2014 4 15 STFX 50 mg 10% 2011 8 1 100 mg 1 1 2011 12 2013 5 226 1,186 1,089 1,069 2.11% 23/1,089 1.10% 12/1,089

More information

VOL. 23 NO. 3 CHEMOTHERAPY 1067 Table 2 Sensitivity of gram positive cocci isolated from various diagnostic materials Table 3 Sensitivity of gram nega

VOL. 23 NO. 3 CHEMOTHERAPY 1067 Table 2 Sensitivity of gram positive cocci isolated from various diagnostic materials Table 3 Sensitivity of gram nega 1066 CHEMOTHERAPY MAR. 1975 Table 1 Sensitivity of standard strains VOL. 23 NO. 3 CHEMOTHERAPY 1067 Table 2 Sensitivity of gram positive cocci isolated from various diagnostic materials Table 3 Sensitivity

More information

CHEMOTHERAPY FEB Table 1. Activity of cefpirome and others against clinical isolates

CHEMOTHERAPY FEB Table 1. Activity of cefpirome and others against clinical isolates VOL.39 S-1 CHEMOTHERAPY FEB. 1981 Table 1. Activity of cefpirome and others against clinical isolates VOL.39 S-1 CHEMOTHERAPY FEB. 1991 72 M, 55.5 kg 66 F, 53 kg Chronic bronchitis Bronchopneumonia Peak

More information

Table 1. Antibacterial activity of cefdinir, cefixime, cefteram, cefuroxime, cefaclor and amoxicillin against standard strains Inoculum size: 108 cells/ml CFDN: cefdinir, CFIX: cefixime, CFTM: cefteram,

More information

日本化学療法学会雑誌第54巻第S-1号

日本化学療法学会雑誌第54巻第S-1号 β β Key words β Candida krusei Candida glabrata β I β Drugadministration Baselinecharacteristics Clinicalsymptom Mycologicaltests Plasmadrugconcn Adverseevents Laboratorytests ) -leadecg Clinicalphotograph

More information

浜松地区における耐性菌調査の報告

浜松地区における耐性菌調査の報告 平成 28 年度浜松地区感染対策地域連携を考える会 2017 年 2 月 22 日 浜松地区 耐性菌サーベイランス報告 浜松医科大学医学部附属病院 感染対策室 概要 平成 19 年 4 月に施行された改正医療法により すべての医療機関において管理者の責任の下で院内感染対策のための体制の確保が義務化されました 本サーベイランスは 静岡県浜松地区 ( 浜松市 湖西市 ) における薬剤耐性菌の分離状況や薬剤感受性の状況を調査し

More information

日本化学療法学会雑誌第61巻第4号

日本化学療法学会雑誌第61巻第4号 μ μ μ μ μ μ Key words I β μ Sex Age (years) Height (cm) Evaluation items Table1.Characteristics of patients 1. mg/kg/day (n14) 2.5 mg/kg/day (n9) 5. mg/kg/day (n9) Total (n32) male 12 8 7 27 female 2 1

More information

日本化学療法学会雑誌第51巻第2号

日本化学療法学会雑誌第51巻第2号 piperacillin piperacillin PIPC. g Cmax CL PIPC CL CLR CLNR CL PIPC g g Cmax PIPC Key words: piperacillin Piperacillin PIPC PIPC g g PIPC Cmax g g ml g g ml g g ml T T T PIPC g g T Ccr ml min AUCCmax PIPC

More information

DIC vegetation 1 nonbacterial thrombogenic e

DIC vegetation 1 nonbacterial thrombogenic e 2001 2002 Guidelines for the Prevention and Treatment of Infective Endocarditis (JCS 2003) h 1 1 2 3 4 5 6 7 8 9 2 1 2 3 1 2 3 4 1 2 5 1 2 1 G Streptococcus viridans Streptococcus bovis 2 G Streptococcus

More information

epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia

epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia Table 3. Overall clinical efficacy of cefozopran in

More information

THE JAPANESE JOURNAL OF ANTIBIOTICS 68 3 June 2015 Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis % 2 S. pneumon

THE JAPANESE JOURNAL OF ANTIBIOTICS 68 3 June 2015 Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis % 2 S. pneumon June 2015 THE JAPANESE JOURNAL OF ANTIBIOTICS 68 3 189 49 1 : 14 1 2 2 3 1 2 3 2015 4 3 1 : 14 CVA/AMPC 1 : 14 27 CVA/AMPC 1 : 14 88.5% Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis

More information

untitled

untitled Seminal paper Anhalt JP Pioneering paper Claydon MA Kishnamurthy T Enterobacter B. cereus Routine identification paper Eigner U Seng P Cherkaoui A Saureus S. Saureus* S. Vagococcus Haemophilus Mycobacterium

More information

「産業上利用することができる発明」の審査の運用指針(案)

「産業上利用することができる発明」の審査の運用指針(案) 1 1.... 2 1.1... 2 2.... 4 2.1... 4 3.... 6 4.... 6 1 1 29 1 29 1 1 1. 2 1 1.1 (1) (2) (3) 1 (4) 2 4 1 2 2 3 4 31 12 5 7 2.2 (5) ( a ) ( b ) 1 3 2 ( c ) (6) 2. 2.1 2.1 (1) 4 ( i ) ( ii ) ( iii ) ( iv)

More information

R01

R01 1. 集計対象医療機関数 (1,792 医療機関 ) 13.2% (7 医療機関 ) 900 床以上 N=53 86.8% (46 医療機関 ) 19.2% (70 医療機関 ) 500 899 床 N=365 80.8% (295 医療機関 ) JANIS 参加 * 200 499 床 N=2,231 43.4% (968 医療機関 ) 56.6% (1,263 医療機関 ) JANIS 参加 200

More information

Staphylococcus sp. K.pneumoniae P.mirabilis C.freundii E. cloacae Serratia sp. P. aeruginosa ml, Enterococcus avium >100ƒÊg/ml

Staphylococcus sp. K.pneumoniae P.mirabilis C.freundii E. cloacae Serratia sp. P. aeruginosa ml, Enterococcus avium >100ƒÊg/ml CHEMOTHERAPY SEPT. 1992 cefoperazone ceftazidime (CAZ), imipenem (IPM) Staphylococcus sp., Enterococcus (CPZ), faecalis, Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae,

More information

日本消化器外科学会雑誌第41巻第1号

日本消化器外科学会雑誌第41巻第1号 Table Profilesofthepatientswithsevereacutepancreatitis Gender(male:female) Age(years) Etiology Alcohol Cholelithiasis Hyperlipidemia Idiopathic Post-ERCP MHLW severityscore(stage) stage stage stage4 SOFA

More information

第65回日本化学療法学会東日本支部総会 抄録

第65回日本化学療法学会東日本支部総会 抄録 鍵 76 Clostridioides difficile C. difficile 77 γ γ Mycobacterium avium 78 79 Clostridium difficile Treponema pallidum 80 81 82 in vitro in vitro 83 鍵 Treponema pallidum 84 Chlamydia trachomatis Mycoplasma

More information

日本化学療法学会雑誌第65巻第4号

日本化学療法学会雑誌第65巻第4号 Mycoplasma pneumoniae M. pneumoniae M. pneumoniae M. pneumoniae M. pneumoniae M. pneumoniae Key words Mycoplasma pneumoniae Mycoplasma pneumoniae M. pneumoniae I M. pneumoniae M. pneumoniae M. pneumoniae

More information

CHEMOTHERAPY DEC (NFLX), ofloxacin (OFLX), ciprofloxacin (CPFX) Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecali

CHEMOTHERAPY DEC (NFLX), ofloxacin (OFLX), ciprofloxacin (CPFX) Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecali CHEMOTHERAPY DEC. 1988 (NFLX), ofloxacin (OFLX), ciprofloxacin (CPFX) Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis Pseudomonas aeruginosa, Serratia ma- Fig. 1. Chemical

More information

Tanigawara Y, Nomura H, Kagimoto N, Okumura K, Hori R. Premarketing population pharmacokinetic study of levofloxacin in normal sub

Tanigawara Y, Nomura H, Kagimoto N, Okumura K, Hori R. Premarketing population pharmacokinetic study of levofloxacin in normal sub 250 mg500 mg 2.7.5 2.7.5 2.7.5 2.7.2 1 Tanigawara Y, Nomura H, Kagimoto N, Okumura K, Hori R. Premarketing population pharmacokinetic study of levofloxacin in normal subjects and patients with infectious

More information

CHEMOTHERAPY NOV S. aureus, S. epidermidis, E. coli, K. pgeumoniae, E. cloacae, S. marcescens, P. mirabilis, Proteus, P. aeruginosa Inoculum siz

CHEMOTHERAPY NOV S. aureus, S. epidermidis, E. coli, K. pgeumoniae, E. cloacae, S. marcescens, P. mirabilis, Proteus, P. aeruginosa Inoculum siz VOL.33 S-5 CHEMOTHERAPY 381 Fig. 1 Chemical structure of HAPA-B Chemical name 1-N-[(2S)-3-Amino-2-hydroxypropiony1]-4-0-(6-amino- 6-deoxy-a-D-glucopyranosyl)-6-013-deoxy-4-C-methyl- 3-(methylamino)-ƒÀ-L-arabinopyranosyl]-2-deoxystreptamine

More information

4月号 学会特集号 122247/16)一般演題目次

4月号 学会特集号 122247/16)一般演題目次 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 48 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 49 60 61 62 63 64 65 66 67 68

More information

44 4 I (1) ( ) (10 15 ) ( 17 ) ( 3 1 ) (2)

44 4 I (1) ( ) (10 15 ) ( 17 ) ( 3 1 ) (2) (1) I 44 II 45 III 47 IV 52 44 4 I (1) ( ) 1945 8 9 (10 15 ) ( 17 ) ( 3 1 ) (2) 45 II 1 (3) 511 ( 451 1 ) ( ) 365 1 2 512 1 2 365 1 2 363 2 ( ) 3 ( ) ( 451 2 ( 314 1 ) ( 339 1 4 ) 337 2 3 ) 363 (4) 46

More information

i ii i iii iv 1 3 3 10 14 17 17 18 22 23 28 29 31 36 37 39 40 43 48 59 70 75 75 77 90 95 102 107 109 110 118 125 128 130 132 134 48 43 43 51 52 61 61 64 62 124 70 58 3 10 17 29 78 82 85 102 95 109 iii

More information

THE JAPANESE JOURNAL OF ANTIBIOTICS 48-8 Enterococcus avium 5Š, Corynebacterium xerosis 10Š, Corynebacterium pseudodiphtheriticum 10Š, Corynebacterium

THE JAPANESE JOURNAL OF ANTIBIOTICS 48-8 Enterococcus avium 5Š, Corynebacterium xerosis 10Š, Corynebacterium pseudodiphtheriticum 10Š, Corynebacterium THE JAPANESE JOURNAL OF ANTIBIOTICS 48-8 Enterobacter spp., Serratia spp., Burkholderia cepacia, Flavobacterium spp., Alcaligenes spp. THE JAPANESE JOURNAL OF ANTIBIOTICS 48-8 Enterococcus avium 5Š, Corynebacterium

More information

日本化学療法学会雑誌第58巻第S-2号

日本化学療法学会雑誌第58巻第S-2号 μ Key words Streptococcus pneumoniae β Haemophilus influenzae β Moraxella Branhamella catarrhalis I F F H C SO H H O H N N N N F CO H O Fig.1. Chemicalstructureoftosufloxacintosilatehydrate. α Body weight

More information

CHEMOTHERAPY OCT. 1994 Tazobactam Piperacillin Fig. I. Chemical structures of tazobactam and piperacillin. Table 1. Media used for preculture and MIC determination BHIB: Brain heart infusion broth (Difco),

More information

概要 (2004 年分 ) 本サーベイランスは 参加医療機関において血液および髄液から分離された各種細菌の検出状況や薬剤感受性パターンの動向を把握するとともに 新たな耐性菌の早期検出等を目的とする これらのデータを経時的に解析し臨床の現場に還元することによって 抗菌薬の安全で有効な使用方法や院内感染制御における具体的かつ確実な情報を提供する 検体 ( ) 内は施設数 2002 年 2003 年 2004

More information

概要 (2006 年 1 2 3 月分 ) 本サーベイランスは 参加医療機関において血液および髄液から分離された各種細菌の検出状況や薬剤感受性パターンの動 向を把握するとともに 新たな耐性菌の早期検出等を目的とする これらのデータを経時的に解析し臨床の現場に還元することによって 抗菌薬の安全で有効な使用方法や院内感染制御における具体的かつ確実な情報を提供する 検体 2005 年 2006 年 10~12

More information

CHEMOTHERAPY

CHEMOTHERAPY VOL.40 S-1 coagulase negative Staphylococcus sp, methicillin- resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Escherichia coli, Citrobacter freundii, Klebsiella pneumoniae, Enterobacter

More information

mg (1) (2) QT (3) 1 400mg 1 1 2

mg (1) (2) QT (3) 1 400mg 1 1 2 17 8 10 400mg 14 9 30 1 400mg 1 C21H24FN3O4 HCl 437.89 1 6 8 7 [(4aS, 7aS) [3,4 b] 6 ] 4 1,4 3 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridine -6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic

More information

日本化学療法学会雑誌第58巻第2号

日本化学療法学会雑誌第58巻第2号 Key words β Candida Table1. MCFGCPAstudygroup Investigator (representative) YoshitsuguMiyazaki NaoyukiMiyashita RyoichiAmitani KenjiOgawa AtsuyukiKurashima ToshiroKiguchi MichiakiMishima YuichiInoue HiroshiSaito

More information

HPM_442_F_TgCHG_1128

HPM_442_F_TgCHG_1128 3M TM Chlorhexidine Gluconate IV Securement Dressings Tegaderm TM CHG Support CRBSI Prevention TegadermTM CHG Dressing 2w/w% 60% N. Safdar, Intensive Care Med 2004 30 62-7 Guideline Centers for Disease

More information

Fig.2. Sensitivity distribution of clinical isolates of S. epidermidis (24 strains, 106 CFU/ml) Staphylococcus aureus Staphylococcus epider- midis Ent

Fig.2. Sensitivity distribution of clinical isolates of S. epidermidis (24 strains, 106 CFU/ml) Staphylococcus aureus Staphylococcus epider- midis Ent Fig.2. Sensitivity distribution of clinical isolates of S. epidermidis (24 strains, 106 CFU/ml) Staphylococcus aureus Staphylococcus epider- midis Enterococcus faecalis Klebsiella pneumoniae, Morganella

More information

CHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX

CHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX Fig. 1 Chemical structure of CXM-AX NOV. 1986 Fig. 2 Sensitivity distribution of clinical isolates organisms (106 cells/ml) a Smurcus 27 strains d) P.m irabilis 15 strains b Ecol i 27 strains 111.morganii

More information

公開情報 2016 年 1 月 ~12 月年報 院内感染対策サーベイランス集中治療室部門 3. 感染症発生率感染症発生件数の合計は 981 件であった 人工呼吸器関連肺炎の発生率が 1.5 件 / 1,000 患者 日 (499 件 ) と最も多く 次いでカテーテル関連血流感染症が 0.8 件 /

公開情報 2016 年 1 月 ~12 月年報 院内感染対策サーベイランス集中治療室部門 3. 感染症発生率感染症発生件数の合計は 981 件であった 人工呼吸器関連肺炎の発生率が 1.5 件 / 1,000 患者 日 (499 件 ) と最も多く 次いでカテーテル関連血流感染症が 0.8 件 / 公開情報 2016 年 1 月 ~12 月年報 院内感染対策サーベイランス集中治療室部門 集中治療室(ICU) 部門におけるサーベイランスの概要と目的 本サーベイランスの目的は 集中治療室 (Intensive Care Unit : ICU) における人工呼吸器関連肺炎 尿路感染症 カテーテル関連血流感染症の発生状況 * を明らかにすることである 集計対象医療機関の各感染症発生率を 1,000 患者

More information

600mg 600mg CTD 2 2.5 2.5 Page 3 2.5...7 2.5.1...7 2.5.2...27 2.5.3...28 2.5.4...42 2.5.5...55 2.5.6...79 2.5.7...97 2.5 Page 5 73 67 31 48 48A 102 104 105 106 ALP ALT(GPT) AST(GOT) AUC AUEC BID BUN

More information

Acecide_ProductsInformation2010PDF.indd

Acecide_ProductsInformation2010PDF.indd 53-0115-00-4PDF 53-0115-00-4PDF INDEX 1 3 9 11 12 16 21 38 39 40 42 43 44 45 46 47 53-0115-00-4PDF 3 1 Critical Semicritical Noncritical Disinfection Sterilization 53-0115-00-4PDF 2 53-0115-00-4PDF O =

More information

CHEMO THE RAPY OCT. 1994

CHEMO THE RAPY OCT. 1994 bilis (0.78), Proteus vulgaris (1.56), Enterococcus faecalis (3.13), Staphylococcus epidermidis (6.25), Klebsiella pneumoniae (6.25), Morganella morganii (6.25), Escherichia coli (12.5), Providencia rettgeri

More information

coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, F

coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, F VOL.43 S-1 coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, Flavobacter- Table 1. Concentration of grepafloxacin

More information

pneumoniae 30, C. freundii 32, E. aerogenes 27, E. cloacae 32, P. mirabilis 31, P. vulgaris 34, M. morganii 32, S. marcescens 31, H. influenzae 27, P.

pneumoniae 30, C. freundii 32, E. aerogenes 27, E. cloacae 32, P. mirabilis 31, P. vulgaris 34, M. morganii 32, S. marcescens 31, H. influenzae 27, P. pneumoniae 30, C. freundii 32, E. aerogenes 27, E. cloacae 32, P. mirabilis 31, P. vulgaris 34, M. morganii 32, S. marcescens 31, H. influenzae 27, P. aeruginosa 30, P. maltophilia pyogenes 32, Escherichia

More information

日本化学療法学会雑誌第54巻第1号

日本化学療法学会雑誌第54巻第1号 Chlamydophila pneumoniae Chlamydophila psittaci Mycoplasma pneumoniae Legionella pneumophila C. pneumoniae C. psittaci C. pneumoniae C. psittaci M. pneumoniae M. pneumoniae C. psittaci L. pneumophila C.

More information

CHEMOTHERAPY APRIL 1992 Table 2. Concentration of meropenem in human prostatic fluid Table 1. Background of 21 chronic complicated UTI cases * NB + BPH, NB + Kidney tumor, NB + Kidney tuberculosis Table

More information

VOL.42 S-1 methicillin-susceptible Staphylococcus aureus (MSSA), Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, Klebsiella pneum

VOL.42 S-1 methicillin-susceptible Staphylococcus aureus (MSSA), Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, Klebsiella pneum VOL.42 S-1 methicillin-susceptible Staphylococcus aureus (MSSA), Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae methicillin-resistant Staphylococcus

More information

公開情報 2016 年 1 月 ~12 月年報 ( 全集計対象医療機関 ) 院内感染対策サーベイランス検査部門 Citrobacter koseri Proteus mirabilis Proteus vulgaris Serratia marcescens Pseudomonas aerugino

公開情報 2016 年 1 月 ~12 月年報 ( 全集計対象医療機関 ) 院内感染対策サーベイランス検査部門 Citrobacter koseri Proteus mirabilis Proteus vulgaris Serratia marcescens Pseudomonas aerugino 公開情報 2016 年 1 月 ~12 月年報 ( 全集計対象医療機関 ) 院内感染対策サーベイランス検査部門 検査部門におけるサーベイランスの概要と目的 本サーベイランスの目的は 細菌検査により検出される主要な細菌の分離頻度とその抗菌薬感受性を継続的に収集 解析し 医療機関における主要な細菌ならびに薬剤耐性菌の分離状況を明らかにすることである サーベイランスの対象となる主要菌ならびに薬剤耐性菌の分離率は

More information

Staphylococcus epidermidis Streptococcus pneumoniae Staphylococcus epidermidis Streptococcus pneumontae S. epidermidis Table 1. Summary of the organis

Staphylococcus epidermidis Streptococcus pneumoniae Staphylococcus epidermidis Streptococcus pneumontae S. epidermidis Table 1. Summary of the organis Staphylococcus aureus S. aureus (MRSA) vancomycin (VCM), arbekacin (ABK) Streptococcus pneumoniae cefuzonam (CZON), cefpirome (CPR) S. pneumoniae Enterococcus faecalis ampicillin (ABPC), imipenem (IPM)

More information

Feb THE JAPANESE JOURNAL OF ANTIBIOTICS Tebipenem pivoxil 1 1, Meiji Seika 2 Meiji Seika G 3 Meiji Seika Tebipen

Feb THE JAPANESE JOURNAL OF ANTIBIOTICS Tebipenem pivoxil 1 1, Meiji Seika 2 Meiji Seika G 3 Meiji Seika Tebipen Feb. 2016 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 1 53 53 Tebipenem pivoxil 1 1, 3 2 2 1 1 Meiji Seika 2 Meiji Seika G 3 Meiji Seika 2015 12 15 Tebipenem pivoxil 10% 2010 4 2013 3 3,547 3,540 3,540 3,331

More information

Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates

Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates Table 2-1. Summary of patients treated with grepafloxacin for respiratory infection 1) Out: outpatient,

More information

O1-1 O1-2 O1-3 O1-4 O1-5 O1-6

O1-1 O1-2 O1-3 O1-4 O1-5 O1-6 O1-1 O1-2 O1-3 O1-4 O1-5 O1-6 O1-7 O1-8 O1-9 O1-10 O1-11 O1-12 O1-13 O1-14 O1-15 O1-16 O1-17 O1-18 O1-19 O1-20 O1-21 O1-22 O1-23 O1-24 O1-25 O1-26 O1-27 O1-28 O1-29 O1-30 O1-31 O1-32 O1-33 O1-34 O1-35

More information

i

i 14 i ii iii iv v vi 14 13 86 13 12 28 14 16 14 15 31 (1) 13 12 28 20 (2) (3) 2 (4) (5) 14 14 50 48 3 11 11 22 14 15 10 14 20 21 20 (1) 14 (2) 14 4 (3) (4) (5) 12 12 (6) 14 15 5 6 7 8 9 10 7

More information

プライマリーケアのためのワンポイントレクチャー「総論」(2017年4月12日開催)

プライマリーケアのためのワンポイントレクチャー「総論」(2017年4月12日開催) 総論 感染症診療の基本 感染制御部中村造 task300@tokyo-med.ac.jp お薦め図書 ( ポケット本 ) 初級者用辞書 中級者以上の必須本 Empiric therapy 用 初級者用マニュアル お薦め図書 ( 臨床の教科書 ) 物語的にまとめた本 辞書的な本 本日のポイント 1 感染症の 3 要素を押さえて診療する 2 グラム染色で菌を推定する 3 抗菌薬を勉強するにはまずは Spectrum

More information

第1部 一般的コメント

第1部 一般的コメント (( 2000 11 24 2003 12 31 3122 94 2332 508 26 a () () i ii iii iv (i) (ii) (i) (ii) (iii) (iv) (a) (b)(c)(d) a) / (i) (ii) (iii) (iv) 1996 7 1996 12

More information

プライマリーケアのためのワンポイントレクチャー「抗菌薬①」(2016年4月27日)

プライマリーケアのためのワンポイントレクチャー「抗菌薬①」(2016年4月27日) プライマリーケアのためのワンポイントレクチャー @ 東京医科大学病院 2016 年 4 月 27 日 ( 水 ) 抗菌薬 1 東京医科大学病院感染制御部 感染症科佐藤昭裕 感染症診療の原則 感染臓器 微生物 抗菌薬 細菌の分け方 グラム染色で染まる細菌の分け方 グラム 陽性球菌 グラム 陽性桿菌 グラム 陰性球菌 グラム 陰性桿菌 グラム陽性球菌 GPC Staphylococcus aureus

More information

立命館21_松本先生.indd

立命館21_松本先生.indd 2143-552010 1 2 () 1 2 3 456 78- Key Words 1 3 12007 2 3 508 19992008 1 23 4 43 2120107 4 2008 1992 2003 2005 1989 2008 4 2 2-1 10 4 4 6 5 4 5 2946 1 155 11 41 44 45 4 2-2 2003 1 21 2 1 3 4 5 6 7 3 2120107

More information

立命館20_服部先生.indd

立命館20_服部先生.indd 20 93-105 2010 2 () ' - 1 ( ) ( ' 2005) Key Words 2 1967 93 20 2010 1 94 1 ' 2002 2 2 1996 1996 1999 2 2 2 1993 1999 4 1 2 1985 1989 1986 1994 4 1 2 1 1 4 2 4 4 1 4 1966 4 10-1970 20 1993-1972 95 20 2010

More information

1996 2000 2004 1984 2005 7150 000 9 500 9 4 13 10 95 11 11 12 20002004 9 70

1996 2000 2004 1984 2005 7150 000 9 500 9 4 13 10 95 11 11 12 20002004 9 70 14 2006 1 Key Words 2002 3 1 2 3 3 1 2 3 1969 1987 69 1996 2000 2004 1984 2005 7150 000 9 500 9 4 13 10 95 11 11 12 20002004 9 70 14 2006 1 15 71 72 1 22 6 32 9 200 6 3 1 2 2000 10 1 2003 10 2005 6 5 4

More information