Microsoft Word - StatsDirectMA Web ver. 2.0.doc

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1 Web version May 2006 StatsDirect ver May Meta-Analysis for Beginners by using the StatsDirect ver May 2006 Yukari KAMIJIMA 1), Ataru IGARASHI 2), Kiichiro TSUTANI 2) 1) Department of Pharmacoepidemiolog y, Faculty of Medicine, University of Tokyo 2) Department of Pharmacoeconomics, Graduate School of Pharmaceutical Sciences, University of Tokyo

5 Meta-Analysis: MA ,000 MA Systematic Review: SR 2) MA 3) MA 3 1) commercial Comprehensive Metaanalysis, DSAT, MetaWin, Metaxis 2) free available Easy MA, Meta, Meta-Analysist, Meta-Test, RevMan 3) MA Bugs and WinBUGS, SAS, S-Plus, Stata, StatXact, StatsDirect, True Epistat, StatsDirect Kaplan-Meire Chapter 1: StatsDirect Chapter 2: StatsDirect Chapter 3: StatsDirect StatsDirect 1) Multivariate meta-analysis 2) Cumulative meta-analysis 3) Baysian meta-analysis i

6 ii

7 StatsDirect Chapter 1: StatsDirect 1 Chapter 2: StatsDirect 13 Chapter 3: iii

9 Chapter 1: StatsDirect (1) StatsDirect (2) 10 Try 1-1 1

10 (3) Try 1) 2) [click here to read the terms and conditions] StatsDirect 3) StatsDirect Download 1-2 1) 2) 3) 2

11 (4) [click here] 1-3 3

12 (5) 1) 2) 3) Submit 1-4 1) 2) 4

13 (6)

14 (7) WSetupStatsDirect.EXE SetupStatsDirect.EXE 2 3 [Next] 1-6 6

15 (8) [ accept] 1-7 7

16 (9) Program Files 1-8 8

17 (10) StatsDirect 1-9 9

18 (11) [OK] StatsDirect

19 (12) 10 StatsDirect p.5 10 StatsDirect URL StatsDirect StatsDirect * , , , , , , ,800 ** 49 1,165 8,640 * ** FAX VISA Master Amex JCB 11

20 URL:

21 Chapter 2: StatsDirect StatsDirect StatsDirect 1) Odds Ratio 2) Peto Odds Ratio Peto 3) Relative Risk 4) Risk Difference 5) Summary 6) Effect Size 7) Incidence Rate 7 p.20 Odds Ratio 13

22 (1) StatsDirect 1) 2) [OK] ) 1) 14

23 (2) [OK] 1) 10 [OK] (3) StatsDirect 2) 10 URL StatsDirect 2-2 2) 1) 15

24 (3) test.sdw 1) [New StatsDirect Work Book] 2) [OK] 2-3 aspirin 7 Table 1 Table1 Table

25 Table 1 Trial aspirin group placebo group event event total event event total MRC CDP MRC GASP PARIS AMIS ISIS Table 2-1 Trial MRC-1 event event total aspirin placebo Table 2-2 Trial CDP event event total aspirin placebo Table 2-3 Trial MRC-2 event event total aspirin placebo Table 2-4 Trial GASP event event total aspirin placebo Table 2-5 Trial PARIS event event total aspirin placebo Table 2-6 Trial AMIS event event total aspirin placebo Table 2-7 Trial ISIS-2 event event total aspirin placebo

26 Table 1 StatsDirect StatsDirect Stratum Label Total number of patients in EXPERIMENTAL group Number of patients with event in EXPERIMENTAL group event Total number of patients in CONTROL group Number of patients with event in CONTROL group event 5 5 Table 3 Table 3 Trial aspirin group placebo group total event total event MRC CDP MRC GASP PARIS AMIS ISIS

27 (4) StatsDirect Excel Excel Table 3 A Trial B Total number of patients in aspirin group aspirin C Number of patients with event in aspirin group aspirin event D Total number of patients in placebo group placebo E Number of patients with event in placebo group placebo event

28 (5) 1) [Analysis] 2) [Meta-Analysis] 3) [Odds Ratio] 2-5 1) 3) 2) 20

29 (6) 1) Select TOTAL numbers of subjects in EXPERIMENTAL groups [1 column] 2) B B StatsDirect 3) [OK] [OK] / Select numbers of EXPERIMENTAL subjects with DISEASE/OUTCOME [1 column] C [OK] 4) 5) Select stratum LABELS [cancel for default [1 column]] A [OK] 2-6 1) 3) 2) 21

30 (7) [ ]

31 (8) bias assessment plot vertical axis CI confidence interval standard error [standard error] [include CI interval if relevant] [OK] 2-8 (9) 23

32 Chapter 3: [ ] 4) ) Table 3 p.17 Table 3 Stratum 2 aspirin group event 3 placebo group event 4 aspirin group event 5 placebo group event 2) Odds ratio 95%CI 95% M-H Weight Mantel-Haenszel weight [p.72] Fixed effects [p.49] Random effects [p.49] 3) 4) 5) Fixed effects 6) Random effects Fixed effects model 5) Fixed effects Fixed effects model Random effects model 24

33 3-1 1) 2) 3) 4) 5) 25

34 StatsDirect Fixed effects Mantel-Haenszel Random effects DerSimonian-Laird [p.71] 3) Fixed effects Mantel-Haenszel chi-square Mantel-Haenszel Mantel-Haenszel pooled estimate of odds ratio Approximate 95%CI 95% StatsDirect Mantel-Haenszel 95% Robins, Breslow and Greenland method [p.159] 4) Fixed effects Conditional maximum likelihood estimate of pooled odds ratio Exact Fisher 95% confidence interval Fisher 95% Exact Fisher one sided P two sided P p 95% 4 5 Exact mid-p 95% confidence interval 95% Exact Fisher one sided P two sided P p 5) Non-combinability of odds ratios StatsDirect Breslow-Day Woolf p df degree of freedom k 26

35 3-1 1) 2) 3) 4) 5) 27

36 6) Random effects DerSimonian-Laird pooled odds ratio Approximate 95% CI 95% DerSimonian-Laird chi-square [p.72] 7) StatsDirect From regression of normalized effect vs. precision Egger From Kendall's test on standardized effect vs. variance Kendall Begg Mazumdar [p.121] Egger funnel plot α β 0 StatsDirect Intercept y approximate 95% CI 95% p funnel plot p.30 Begg Mazumdar Kendall Kendall tau StatsDirect tau Kendall p not robust, small sample 10% 28

37 3-1 3) 4) 5) 6) 7) 29

38 Fig.1 funnel plot funnel plot p.51 StatsDirect p.22 Part 2. (8) 7) Egger Egger Part 2. 8 [p ] Fig.2 L'Abbe plot 5) aspirin group placebo group event L'Abbe plot 30

39 3-2 Fig.1 Fig.2 31

40 Fig.3 Fixed effects Fig.4 Random effects 32

41 3-3 Fig.3 Fig.4 33

42 34

43 StatsDirect p StatsDirect 1) Odds Ratio Mantel-Haenszel DerSimonian-Laird 2) Peto Odds Ratio Peto 3) Relative Risk Mantel-Haenszel DerSimonian-Laird 4) Risk Difference Mantel-Haenszel DerSimonian-Laird 5) Summary 6) Effect Size 7) Incidence Rate 1) Odds Ratio Mantel-Haenszel DerSimonian-Laird StatsDirect 2) 7) p.20 3) StatsDirect Help 35

44 1). systematic review. 2003; 34(4): ) Sterne JAC, Egger M, Sutton AJ, Meta-analysis software. In: Systematic reviews in health care: meta-analysis in context. BMJ Books, 2002 p ) ; 19(8) 4) ) Song F. Exploring heterogeneity in meta-analysis: Is the L Abbe plot useful? J Clin Epidemiology; 52(8): ,

こんにちは由美子です

こんにちは由美子です Sample size power calculation Sample Size Estimation AZTPIAIDS AIDSAZT AIDSPI AIDSRNA AZTPr (S A ) = π A, PIPr (S B ) = π B AIDS (sampling)(inference) π A, π B π A - π B = 0.20 PI 20 20AZT, PI 10 6 8 HIV-RNA