=PAS.. =.. =.... 1% 01% ] = = = = 4 (A/A 2 / /B ) 1 8 2n / n n 64 n 64 n ] ] 4
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- ひろみ はまもり
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1 : 0: + : +0 : : } = (38 )? [ ] = etc Ru
2 =PAS.. =.. =.... 1% 01% ] = = = = 4 (A/A 2 / /B ) 1 8 2n / n n 64 n 64 n ] ] 4
3 & = 6 = = = = :714 ;2026 ph ( ) K/Na = / = 10 5 : 7 : / 8 : 6 9 : 10 / & / / /
4 for /K/.. +. rat/mouse with / : : for (Ru & S ) ( S 11 ) / : < < : < (+) < < & 11 : & V
5 = / / = etc ph ph 7.0 >>/ AI etc / 510% ml /ml AI ml hrs /6 3/ Mb
6 ( = ) - / ( ) 1 (etc ) n at 3 2n ] / 4 n & 5 n ] 6 n+n 1 : 4 2 / 2 : 5 : Ru 3 : 6 :
7 / & & Ru: 2hour { } 1week [ ] 1week ( ( ) : ( )) [ ( ) ] [ ] / / etc 2 Ru, 7 9 / 8 10 : A A A
8 3 8 3 { } F B1 3 F B2 4 F B FB: GnRH h CRH ACTH h LH/FSH / ACTH 1 / 2 PIF PRL PRL / - OT LH h FSH h / / ACTH h PRL / FB hcg ecg PL PG FSH FB / h LH h FSH 1 β GnRH 2
9 [ ] 2. [ ] / 1. LHFSH FSH GnRHF SH RHLH RH F SHLH ( ) Estrogen/P rogesterone 1. FSH-RH FSH 2. FSH E 3. E LH-RH 4. LH-RH LH 5. LH FSH E P E 6. E 7. FSH-RH LH-RH 8. LH LH E P 9. P LH FSH-RH FSH 2. FSH =FSH FSH 3 - -
10 gonadotropin GnRH LHFSH / / FSH/LH LHRH/FSHRH GnRH LH GnRH FB(-)= FB(+)= GnRH 4 GnRH-analogue LH/FSH LH/FSH 5 6 LHRH etc LH etc = ? 6 GnRH LH?
11 FSH LH FSH LH 7 ( ) 8 / 9 / LH FSH / LH [LH ] GnRH & = LH LH/FSH / + LH PIH TRHE / etc / = / = 7 FSH 9 LH 8 FSH FSH
12 LH ( ) / / / etc etc = BW GTHFSH/LH Androgen sterility etc 1 : 3065 : 2223 : (E 1 ) (E 2 ) (E 3 E ) estriol LH F SH / 10 () + FSH/LH LH E/P E + 10 E+: / / /
13 LH FSH LH FSH/LH + LH +E 13 etc LH 19- P // / /// 14 // 11 : / / // / 12 P : / / :
14 FSH / FSH LH 15 GnRH ecg PMSG MW:53k FSH LH PMSG = FSH LH hcg LH / /Ru 15 GnRH GTH GnRH LH
15 local hormone or / / F 2α etc? CCMCounter Current Mechanism PGF 2α CCM PGF 2α V V A V /// PGF 2α / / ex 19 / 16 PGF 2α : & 17 PG etc GTH PGF 2α 18 : 19 etc LH /
16 / GnRH 1 etc etc 4.1 = P / = / = [ ] 1 : : 2 :
17 = [ ] SM + [ ]= SM [ ] SM - + SM = [ ] + [ ] = GnRH = SM
18 delayed implantation 3 3 4
19 Ru 5.2 etc /
20 (+) non-return A / P 2124 >1ng/ml / >10ng/ml E cm cf. etc 1 2 / 3 4 PMSG 40 6 E P 16/17 or E B A A 90 A <2 2 >24 =1 E 2231/80 P 21 E 17
21 ph ( ) () () A A 5 B DMSO etc ph etc 1 cf. p.4 p.5
22 / / PMSG PGF 2α PGF 2α / PGE 2 PGF 2α
23 / = 6mm / etc I 2 A Ca /2 / 4. (710 )/ 3 / (β- 4 ) FSH/PMSG PGF 2α 2 3 cf &LH/hCG AI () (Ru= ) / / : :4 2 3 II = 1/3 III = 4 β- +68 IV = 5 10% 1030% 50% /8 /
24 / ( etc) ( etc) / / etc / / etc = = = / 1 or / 1 = =
25 / 1% = / 7.3 1/2/3 4/5 etc
26 / / / = = / H-Y 3. XX/XY % XX XX/XY XY/XYY / ex. = & 2 1/80 1/200
27
1 2 1.2 1.2.1 =PAS.. =.. =.... 1% 01% ] 1.2.2 = = = = 4 (A/A 2 / /B ) 1 8 2n / 16 32 2n n 64 n 64 n ml /ml AI ml 50 5 10 0.5 0.25-0.5 30 1 30 1 0.2-0.
1 1 1 1.1 1.1.1 3 : 0: + : +0 : : } 40 40 40 = 3 35 35 (38 )? +0+7 30 35-0+0 38 38 +30 5 30 30 +20 16 16 1. [ ] 2. 3. 4. + = etc 1.1.2 Ru 1 2 1.2 1.2.1 =PAS.. =.. =.... 1% 01% ] 1.2.2 = = = = 4 (A/A 2
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