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10 ED ADL/QOL The European Working Group on Sarcopenia in Older People EWGSOP Asian Working Group for Sarcopenia AWGS D

11 C Zhang, 2006 C Imamura, 2008 ATP Imamura, 2009 Imamura, C Imamura, 2008 TRPM8 Chen, 2009; Zhang, 2012 TRPM8 Noguchi, 2013 Imamura, 2013 C TRPM8 Imamura, 2013

12 A 230 B 93 C 71 D 50 E A 31 B cm 52.2kg 17 H H16/4/6 S GIF 5g H19/3 4/18 UFM 74ml 8.2ml/s US H19/4/ /27 15g 11 H22/2/3 H26/11 H27/3/31 H27/9 12/8 K K 8

13 / g 1 3 BPSD Behavioral and Psychological Symptoms of Dementia DRS Delirium Rating Scale / / % 0% BPSD DRS / 2013 robot-assisted radical prostatectomy: RARP RARP RARP 178 RARP

14 LOH Aging male s symptoms AMS T luteinizing hormone LH follicle-stimulating hormone FSH ng/dL, LH miu/ml % % % % % % % vs.603, P = vs.42 %, P= LOH ESWL TUL PNL ESWL , BMI kg/m , mm 3.75, mm R2 1 R3 2 U1 5 U2 2 U , , % 5mm % 10mm % 14

15 CRPC 12.8% 21.5% Cancer Fatigue Scale CFS CRPC CFS 72 PSA1765ng/ml Gleason score4+4 adenocarcinoma CT 1 3 CRPC 3 8 PSA 2 CFS CFS 36 4 CFS 20 PSA C PSA3122ng/ml ct4n0m1 multiple OSS Gleason Score CAB PSA Nadir Nadir 1.675ng/ml 2 PSA Fe 135 g/dl 238ng/ml Alb 4.2g/dL PSA7.7ng/ml 8 ct2 N0M0 Gleason Score 3+3 high risk 11 CAB AST 167U/L/ALT 312U/L CAB PSA12.467ng/ml MRI T3a 3 2 AST 729U/L ALT 719U/L ALP 1189U/L GTP 627U/L 3.2mg/dL CT 1 AST 32 ALT 75 LDH 179 ALP 745 GTP PSA

16 89 CEA Urothelial Carcinoma, high grade, pt2b, CEA 6 CEA CT 4 CEA CT stable disease SD MSKCC Karnofsky Performance Status KPS mg % CTCAE v4.0 G2:8 G3:4 2.5g* KPS Hb p<0.05 KPS p= p= kg p= g/dL p=0.008 Hb g/dL p= PGE2

17 SD 0.04 / 0.1% 1% / 4 1% 1% 1% 1% Pelvic Congestion model; PC PC SD PC Sham NOx Real time RT-PCR enos nnos mrna Sham PC PC PC NOx Sham PC enos nnos mrna PC enos mrna Sham 2 2 NOx

18 distigmine,bethanechol,tramsulosin 9 3 distigmine,bethanechol,urapidil 16 3 retrospective bethanechol NSAIDs 39 G1P mg 1800mg 2 5g 3/day 1 7.5g/day off 7.5g/day 7.5g/day 600mg/day 36 1

19 LUTS QOL 1 LUTS LUTS IPSS 8 LUTS IPSS QOL UFM 8-OHdG IPSS 8-OHdG LUTS 1 30 IPSS IPSS-QOL BII score UFM 8-OHdG hanp IPSS IPSS-QOL BII score NPI 1

20 LUTS OABSS add on QOL Quality of Life TJ-54 R 1 2.5g OABSS 1 HUS PSQIP< OABSS P<0.001 OABSS Q P< P<0.001 HUS P=0.002 PSQI P<

21 LUNA / %

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Imamura, 200827-30 4-8 20 C Imamura, 2008 TRPM8 Chen, 2009; Zhang, 2012Chen, 2009 Noguchi, 2013) Yamagishi, 2013 1 TRPM8 C Imamura, 2013 Zhang,2006; Imamura, 2008 ATP Imamura, 2009 C C Imamura, 2013 BNP

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