C033** of 7 C034** PEG-IFN-2b + IFN -2b + 78 HCV-RNA PEG-IFN-2b IFN-2b n=250 n=200 n= =10 % % 85 % 74 % %

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1 Genotype 1 C PEG-IFN-2b+ C033* Genotype 1 C PEG-IFN-2b + IFN-2b C033* 1 of 7 Genotype 1 C PEG-IFN-2b+ Genotype 1 C PEG-IFN-2b + IFN-2b + 24 HCV-RNA follow-up 2 46 PEG/R 1:1 PEG-IFN-2b + IFN-2b + IFN/R (PEG-IFN-2b 250 IFN-2b 250 ) 514 (PEG-IFN-2b 258 IFN-2b 256 ) 511 (PEG-IFN-2b 257 IFN-2b 254 ) 507 (PEG-IFN-2b 254 IFN-2b 253 ) FAS 506 (PEG-IFN-2b 254 IFN-2b 252 ) IFN C PEG-IFN-2b + C034* Genotype 1b 100 kcopies/ml HCV-RNA PEG-IFN -2b 1.5 µg/kg + 46 IFN-2b 300 IU IFN-2b 600 IU IFN PEG-IFN -2b + IFN-2b + HCV-RNA C034 PEG-IFN-2b + HCV-RNA IFN -2b + 5 IFN-2b + 41 PEG-IFN-2b + 46 PEG-IFN-2b + IFN -2b

2 C033** of 7 C034** PEG-IFN-2b + IFN -2b + 78 HCV-RNA PEG-IFN-2b IFN-2b n=250 n=200 n= =10 % % 85 % 74 % % 68 % 56 % n Genotype 1 C 20 40kg 100 kg 60 C Genotype 1Genotype 1a 1b HCV-RNA RT-PCR HCV 100 k IU/mL 60 ALT ALT 45 IU/L * (%)0.124 * (ng/ml)0.001 =1, 2 (-0.413) *(/mm 3 )(-0.075)2.005 * g/dl 1,500 /mm 3 10 /mm 3 Cockcroft 51 Ccr =140 (kg) /72 (mg/dl) Ccr Ccr mg/dl 110 mg/dl 126 mg/dl Hb A1c 6.5% 2 polyethylene glycol IFN IFN 30 IFN IFN HBs mmhg grade 3 601

3 C033* 3 of 7 30 C IFN HCG PEG-IFN-2b IFN-2b peginterferon alfa-2binn 1.5 µg/kg b JAN IFN-2b 600 IU (JAN) 6001,000 mg/ PEG/R PEG-IFN-2b + PEG-IFN-2b 1.5g/kg 1/ mg/ 48 IFN/R IFN-2b IFN-2b 600IU 6/ mg/

4 C033* 4 of 7 HIV IFN IL-2 C () Day 1) ) 3) 4) 5) CT X PEGR 1 IFNR 3 a) --#-- b) --#-- c) --#-- HCG --#-- HCV-RNA HCV-RNA HCV genotype HBs f) ml Day1a 2 baltast -GTPALPLDH 314 BUN HbA1C* CRP - * * 4 14 ctshft3ft4trab*tpoab* dbranched DNA probe* HCV 48 e fafppivka-ii * # Day HCV-RNA RT-PCR 24 HCV-RNA 24 HCV-RNA IFN / HCV-RNA RT-PCR 24 HCV-RNA 24 HCV-RNA HCV-RNA RT-PCR HCV-RNA HCV-RNA 603

5 C019* 5 of HCV-RNA RT-PCR 12 HCV-RNA 12 HCV-RNA IFN / 4. ALT ALT ALT ALT ALT 5. ALT ALT 24 ALT 24 ALT ALT IFN / 1. 1) 2) 3)

6 C033* 6 of [FAS PPS PPS ] IFN Wilcoxon-Mann-Whitney test Mantel-Haenszel test Fisher s exact test 1. IFN 2. HCV-RNA RT-PCR HCV ALT 3. PEG-IFN-2bIFN-2b 24 HCV-RNA 1. FAS PEG/R IFN/R -10 PEG/R IFN/R 2. PPS PPS IFN logistic regression analysis IFN HCV-RNA RT-PCR HCV ALT IFN HCV-RNA RT-PCR HCV ALT 605

7 C033* 7 of 7 PEG/R IFN/R ALT ALT 24 HCV-RNA HCV-RNA 24 HCV-RNA HCV-RNA 24 HCV-RNA HCV-RNA ALT HCV-RNA ALT MedDRA 1. skewnesskurtosis 25% 75% grade

8 PEG/R 258 IFN/R PEG/R 257 IFN/R PEG/R 1 IFN/R PEG/R 257 IFN/R PEG/R 20.2%52 /257 IFN/R 21.7%55 /254 / / PEG/R 8.9%23 /257 IFN/R 8.3%21 /254 PEG/R 8.9%23 /257 IFN/R 9.8%25 / PEG/R 257 IFN/R PEG/R 6 IFN/R 13 PEG/R 2.3%6 /257 IFN/R 3.9%10 /254 / / PEG/R 0.0%0 /257 IFN/R 0.4%1 /

9 786 * PEG-IFN-2b IFN-2b * Hb/PLT Hb/PLT 257 /Neu /Neu 21 Hb/PLT Hb/PLT /Neu /Neu PEG-IFN-2b IFN-2b ** 257 ** 254 )

10 C033* (C033*) PEG/R IFN/R PEG-IFN-2b/ IFN-2b 6MIU 6 / 1.5 µg/kg1 / MIU3 / ,000 mg/ 600-1,000 mg/ % % % % 0 0.0% 1 0.4% / / % % / / % % 1 0.4% 0 0.0% 1 0.4% 0 0.0% 1 0.4% 2 0.8% 0 0.0% 1 0.4% A 0 0.0% 4 1.6% % % % % / / 7 2.7% 4 1.6% / / % % / 1 0.4% 1 0.4% 2 0.8% 0 0.0% % % % % % % 6 2.3% % 0 0.0% 1 0.4% 0 0.0% 1 0.4% / / 0 0.0% 1 0.4% % % CHC500CSR14_1_1_4 all randomized subjects ARS Full analysis set FAS FAS Per Plotocol Set PPS FAS PPS ARS FAS ARS 514 PEG/R 258 IFN/R

11 ARS 514 PEG/R 258 IFN/R PEG/R 254 IFN/R PEG/R 4 IFN/R 3 GCP 5 PEG/R 3 IFN/R 2 2 PEG/R 1 IFN/R 1 GCP 5 IFN/R 1 / PEG/R IFN/R 3 PEG-IFN-2b 1 IFN-2b 2 IFN/R 1 PEG/R 1 ARS 514 PEG/R 258 IFN/R 256 FAS 506 PEG/R 254 IFN/R 252 FAS 8 PEG/R 4 IFN/R 4 GCP 5 PEG/R 3 IFN/R 2 2 PEG/R 1 IFN/R 1 IFN-2b 1 IFN/R 1 IFN-2b 1 IFN/R 1 FAS 506 PEG/R 254 IFN/R 252 PPS 429 PEG/R 219 IFN/R 210 PPS 77 PEG/R 35 IFN/R 42 8 PEG/R 4 IFN/R 4 2 PEG/R 1 IFN/R 1 3 PEG/R 1 IFN/R 2 17 PEG/R 6 IFN/R 11 5 PEG/R 1 IFN/R 4 70 PEG/R 32 IFN/R 38 FAS PPS ARS 507 PEG/R 254 IFN/R PEG/R /254 IFN/R 84.6%214 /253 80% PEG/R /254 IFN/R 78.3%198 /

12 C033* PEG/R n= 254 IFN/R n= % % % % % % % % % % % % % % CSR T PEG/R 600 mg / mg /142 1,000 mg /18 IFN/R 600 mg / mg /131 1,000 mg /16 PEG/R mg / mg /142 1,000 mg /18 IFN/R mg / mg /131 1,000 mg / C033* PEG/R n=254 IFN/R n=253 PEG-IFN-2b/IFN-2b 1.5 µg/kg 1.5 µg/kg 1.5 µg/kg 600MIU 600MIU 600MIU 600mg 800mg 1,000mg 600mg 800mg 1,000mg % 97.9% 100.0% 94.3% 96.9% 100.0% % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % 78.9% 88.9% 72.6% 82.4% 81.3% CSR T02 611

13 FAS 506 PEG/R 254 IFN/R C033* 1 of 3 (C033*) PEG/R IFN/R (65.0%) 164 (65.1%) [Fisher's exact test] 89 (35.0%) 88 (34.9%) p = bae % % kg [Wilcoxon Mann Whit ney test] Z= p= (93.3%) 229 (90.9%) [Fisher's exact test] (6.7%) 23 (9.1%) p = % % [Wilcoxon-Mann-Whitn ey test] Z= p= kg 94 (37.0%) 106 (42.1%) [ Mantel-Haenszel 60kg 80kg 142 (55.9%) 130 (51.6%) test] 80kg 18 (7.1%) 16 2 =1.2895df= 1 (6.3%) p= % % [Wilcoxon-Mann-Whitn ey test] Z= p= (2.0%) 7 (2.8%) [ Mantel-Haenszel (19.7%) 66 (26.2%) test] (35.0%) 81 (32.1%) 2 =2.5baedf= (43.3%) 98 (38.9%) p= (21.7%) 43 (17.1%) [Fisher's exact test] 199 (78.3%) 209 (82.9%) p = (53.9%) 139 (55.2%) 91 (35.8%) 81 (32.1%) [Fisher's exact test] IFN 26 (10.2%) 31 (12.3%) p = (0.0%) 1 (0.4%) Genotype 1a 2 (0.8%) 0 (0.0%) [Fisher's exact test] 1b 252 (99.2%) 252 (100.0%) p = a1b 0 (0.0%) 0 (0.0%) 612

14 C033* of 3 (C033*) PEG/R IFN/R no fibrosis 0 (0.0%) 0 (0.0%) mild fibrosis 107 (42.1%) bae (41.3%) [ Mantel-Haenszel moderate fibrosis 109 (42.9%) 114 (45.2%) test] severe fibrosis 34 (13.4%) 30 (11.9%) 2 =0.0211df= 1 staging cirrhosis 1 (0.4%) 3 (1.2%) p= (1.2%) 1 (0.4%) None 0 (0.0%) 0 (0.0%) Minimal chronic 48 (18.9%) 49 (19.4%) hepatitis [ Mantel-Haenszel Mild chronic hepatitis 88 (34.6%) 89 (35.3%) test] Moderate chronic 102 (40.2%) 94 (37.3%) hepatitis 2 =0.0032df= 1 grading Severe chronic p= (5.1%) 19 (7.5%) hepatitis 3 (1.2%) 1 (0.4%) HCV-RNA [Wilcoxon-Mann-Whitn ey test] RT-PCR 75% Z=0.1848p= HCV 25% KIU/mL (8.7%) 16 (6.3%) (12.2%) 38 (15.1%) (28.0%) 68 (27.0%) (51.2%) 130 (51.6%) bae ALT 75% IU/L 25% (6.3%) 16 (6.3%) (47.6%) 117 (46.4%) (34.6%) 96 (38.1%) (11.4%) 23 (9.1%) [ Mantel-Haenszel test] 2 =0.0151df= 1 p= [Wilcoxon-Mann-Whitn ey test] Z= p= [ Mantel-Haenszel test] 2 =0.0007df= 1 p=

15 C033* 3 of 3 (C033*) PEG/R IFN/R [Wilcoxon-Mann-Whitn ey test] g/dl 75% Z= p= % , , , [Wilcoxon-Mann-Whitn 8,000 6,577 /mm 3 ey test] 75% 3,235 3,196 Z= p= ,614 2, % 2,042 2,065 1,376 1, [Wilcoxon-Mann-Whitn /mm 3 ey test] 75% Z= p= % CHC500CSR14_1_4_1&CSR14_1_4_6 Wilcoxon-Mann-Whitney testp= Mantel-Haenszel testp= HCV-RNA ALT 614

16 HCV-RNA HCV-RNA PEG/R /254 IFN/R /252 2 PEG/R IFN/R HCV-RNA PEG/R /254 IFN/R /252 2 PEG/R IFN/R HCV-RNA PEG/R /254 IFN/R /252 2 PEG/R IFN/R HCV-RNA PEG/R /254 IFN/R /252 2 PEG/R IFN/R HCV-RNA PEG/R IFN/R 95% IFN/R PEG/R PEG-IFN-2b+ IFN-2b+ PPS ARS FAS IFN HCV-RNA PEG/R IFN/R 95% PPS %ARS % IFN % HCV-RNA HCV-RNA C033** PEG/R n= 254 IFN/R n= 252 HCV-RNA * 95% 24 n= 254 n= (66.9%) 165 (65.5%) -6.8% 9.7% 57 (22.4%) 53 (21.0%) 27 (10.6%) 34 (13.5%) n= 254 n= (71.7%) 175 (69.4%) -5.7% 10.2% 69 (27.2%) 70 (27.8%) 3 ( 1.2%) 7 ( 2.8%) 12 n= 254 n= (47.6%) 115 (45.6%) -6.7% 10.7% 122 (48.0%) 122 (48.4%) 11 ( 4.3%) 15 ( 6.0%) 24 n= 254 n= (47.6%) 113 (44.8%) -5.9% 11.5% 122 (48.0%) 120 (47.6%) 11 ( 4.3%) 19 ( 7.5%) *PEG/R -IFN/R CSR 14_2_2_1 staging grading 615

17 HCV-RNA RT-PCR ALT / HCV-RNA IFN PEG/R /137 IFN/R /139 PEG/R /91 IFN/R /81 PEG/R /26 IFN/R /31 IFN 24 HCV-RNA HCV-RNA C033** / PEG/R IFN/R HCV-RNA *95% 59/137 (43.1%) 65/139 (46.8%) -15.4%8.0% 57/91 (62.6%) 42/81 (51.9%) -4.0%25.5% IFN 5/26 (19.2%) 6/31 (19.4%) -20.7%20.4% 0/0 (0.0%) 0/1 (0.0%) no fibrosis 0/0 (0.0%) 0/0 (0.0%) mild fibrosis 60/107 (56.1%) 55/bae (52.9%) -10.2%16.6% moderate fibrosis 50/109 (45.9%) 44/114 (38.6%) -5.7%20.2% Stagingsevere fibrosis 11/34 (32.4%) 13/30 (43.3%) -34.7%12.7% cirrhosis 0/1 (0.0%) 0/3 (0.0%) 0/3 (0.0%) 1/1 (100.0%) %-100.0% none 0/0 (0.0%) 0/0 (0.0%) minimal chronic hepatitis 20/48 (41.7%) 20/49 (40.8%) -18.7%20.4% mild chronic hepatitis 52/88 (59.1%) 46/89 (51.7%) -7.2%22.0% moderate chronic Grading 45/102 (44.1%) 41/94 (43.6%) -13.4%14.4% hepatitis severe chronic hepatitis 4/13 (30.8%) 5/19 (26.3%) -27.5%36.4% 0/3 (0.0%) 1/1 (100.0%) %-100.0% /22 (59.1%) 9/16 (56.3%) -29.0%34.7% HCV-RNA /31 (51.6%) 15/38 (39.5%) -11.3%35.6% RT-PCR /71 (38.0%) 22/68 (32.4%) -10.2%21.5% KIU/mL850 65/130 (50.0%) 67/130 (51.5%) -13.7%10.6% /72 (36.1%) 39/87 (44.8%) -24.0%6.5% /93 (51.6%) 35/85 (41.2%) -4.1%25.0% /73 (54.8%) 32/65 (49.2%) -11.1%22.2% mg/kg /16 (43.8%) 6/12 (50.0%) -43.5%31.0% /0 (0.0%) 1/3 (33.3%) 45 5/16 (31.3%) 8/16 (50.0%) -52.2%14.7% /121 (43.8%) 54/117 (46.2%) -15.0%10.3% ALT /88 (51.1%) 42/96 (43.8%) -7.0%21.8% IU/mL /29 (62.1%) 9/23 (39.1%) -3.7%49.6% 65 6/17 (35.3%) 7/23 (30.4%) -24.6%34.3% /237 (48.5%) 106/229 (46.3%) -6.8%11.3% 94/165 (57.0%) 82/164 (50.0%) -3.8%17.7% 27/89 (30.3%) 31/88 (35.2%) -18.7%8.9% Caucasian 0/1 (0.0%) 0/0 (0.0%) Asian 121/253 (47.8%) 113/252 (44.8%) -5.7%11.7% /94 (35.1%) 45/106 (42.5%) -20.8%6.1% /142 (57.7%) 63/130 (48.5%) -2.5%21.1% kg /18 (33.3%) 5/16 (31.3%) -29.4%33.5% *PEG/R -IFN/R CSR14_2_2_314_2_3_714_2_5_1 616

18 stepwise 20% stepwise HCV-RNA PEG/R staging 5%IFN/R staging grading HCV-RNA RT-PCR 5% PEG/R FAS <.0001 R 14 * stepwise IFN/R FAS <.0001 *. stepwise HCV-RNA HCV-RNA

19 HCV-RNA C033* PEG/R n=254 IFN/R n=252 5/253 (2.0%) 16/249 ( 6.4%) 23/249 (9.2%) 31/238 (13.0%) /238 (60.5%) 124/232 (53.4%) /227 (74.9%) 165/218 (75.7%) /218 (78.4%) 162/208 (77.9%) /206 (79.6%) 155/201 (77.1%) 182/251 (72.5%) 175/245 (71.4%) 131/245 (53.5%) 127/239 (53.1%) /243 (49.8%) 115/237 (48.5%) /243 (49.8%) 113/233 (48.5%) 121/244 (49.6%) 114/237 (48.1%) (CSR 14_2_6_2) PEG/R IFN/R HCV-RNA C033* 618

20 HCV-RNA HCV-RNA HCV-RNART-PCR 75% HCV-RNA HCV-RNA HCV-RNA PEG/R 100%5 /5 100%18 / %86 /121 IFN/R 75.0%12 / %16 / %65 /93 24 HCV-RNA PEG/R IFN/R 36.4%12 / %20 /49 24 HCV-RNA HCV-RNA HCV-RNA HCV-RNA C033* HCV-RNA PEG/R n=254 IFN/R n=252 n=5 n= (100.0%) 12 (75.0%) 0 (0.0%) 1 (6.3%) (CSR 14_2_6_3_2) 0 (0.0%) 3 (18.8%) n=18 n=19 18 (100.0%) 16 (84.2%) 0 (0.0%) 3 (15.8%) 0 (0.0%) 0 (0.0%) n=121 n=93 86 (71.1%) 65 (69.9%) 34 (28.1%) 24 (25.8%) 1 (0.8%) 4 (4.3%) n=33 n=49 12 (36.4%) 20 (40.8%) 21 (63.6%) 28 (57.1%) 0 (0.0%) 1 (2.0%) n=11 n=6 0 (0.0%) 0 (0.0%) 11 (100.0%) 6 (100.0%) 0 (0.0%) 0 (0.0%) n=4 n=2 0 (0.0%) 0 (0.0%) 4 (100.0%) 2 (100.0%) 0 (0.0%) 0 (0.0%) n=1 n=1 0 (0.0%) 0 (0.0%) 1 (100.0%) 1 (100.0%) 0 (0.0%) 0 (0.0%) HCV-RNART-PCR 357 PEG/R 182 IFN/R PEG/R 181 IFN/R HCV-RNART-PCR 24 PEG/R IFN/R 33.7%61 / %59 / HCV-RNA 619

21 24 PEG/R IFN/R 0%0 / %2 /115 ALT ALT PEG/R IFN/R 53.9%137 / %140 /252 ALT PEG/R -IFN/R 95% % ALT PEG/R IFN/R 70.5%179 / %165 /252 ALT PEG/R -IFN/R 95% % ALT ALT C033** PEG/R n=254 IFN/R n=252 * ALT 95% n=254 n= (70.5%) 165 (65.5%) -3.1% 13.1% 54 (21.3%) 58 (23.0%) 21 (8.3%) 29 (11.5%) 24 n=254 n= (53.9%) 140 (55.6%) -10.3% 7.1% 71 (28.0%) 58 (23.0%) 46 (18.1%) 54 (21.4%) * PEG/R -IFN/R (CSR 14_2_7_1) PEG/R IFN/R PEG/R 60% 97.2%247 / % 245 / %245 / %242 / %233 / %224 / %220 / %213 / %204 / %202 / %197 / %185 / %182 / %174 / %170 / %155 /254 IFN/R 60% 99.2%251 / %247 / %241 / %238 / %229 / %224 / %220 / %211 / %197 / %190 / %189 / %187 / %180 / %173 / %171 / % 620

22 163 /253 PEG/R IFN/R 5% PEG/R 41.7%IFN/R 3.6% PEG/R 26.0%IFN/R 2.8% PEG/R 79.5%IFN/R 67.6% PEG/R 86.6% IFN/R 74.7% PEG/R 96.5% IFN/R 87.0% PEG/R 80.3%IFN/R 71.1% PEG/R 27.2%IFN/R 18.2% PEG/R 61.0% IFN/R 52.2% PEG/R 8.3% IFN/R 0.8% PEG/R 21.3%IFN/R 14.6% PEG/R 35.0%IFN/R 29.2% PEG/R 5.9%IFN/R 0.4% PEG/R 8.3% IFN/R 3.2% PEG/R 18.9% IFN/R 13.8% IFN/R PEG/R 5% PEG/R 18.5%IFN/R 30.8% PEG/R 3.9%IFN/R 13.4% PEG/R 33.1%IFN/R 41.9% PEG/R 66.9% IFN/R 75.1% PEG/R 16.1% IFN/R 23.3% PEG/R 6.7% IFN/R 13.0% PEG/R 57.9%IFN/R 64.4% PEG/R 83.9% IFN/R 90.5% PEG/R 35.8%IFN/R 42.3% PEG/R46.1% IFN/R52.6% PEG/R28.0% IFN/R34.4% PEG/R 13.8% IFN/R 19.4% PEG/R 77.6% IFN/R 83.4% PEG/R 5.1% IFN/R 10.3% PEG/R 68.5% IFN/R 73.9% PEG/R 72.8%IFN/R 77.9% PEG/R IFN/R IFN/R PEG/R PEG/R IFN/R 5% PEG/R 19.3%IFN/R 7.1% PEG/R 28.7%IFN/R 17.8% IFN/R PEG/R 5% PEG/R 78.0%198 /254 IFN/R 73.5%186 / %158 / %147 / %73 / %45 / %49 / %18 /253 PEG/R IFN/R PEG/R IFN/R PEG/R 621

23 IFN/R PEG/R IFN/R IFN PEG/R IFN/R PEG/R / /223 IFN/R / /214 PEG/R / /223 IFN/R / /214 PEG/R / /223 IFN/R / / PEG/R IFN/R kg 60 kg 60 kg 80 kg 80 kg 100 kg 622

24 PEG/R C033*1 of 15 PEG/R n=254 2 (0.8%) 54 (21.3%) 198 (78.0%) 254 (100.0%) 19 (7.5%) 7 (2.8%) 0 (0.0%) 26 (10.2%) 16 (6.3%) 4 (1.6%) 0 (0.0%) 20 (7.9%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 4 (1.6%) 1 (0.4%) 0 (0.0%) 5 (2.0%) 47 (18.5%) 7 (2.8%) 2 (0.8%) 56 (22.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 47 (18.5%) 5 (2.0%) 2 (0.8%) 54 (21.3%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 24 (9.4%) 10 (3.9%) 0 (0.0%) 34 (13.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 7 (2.8%) 1 (0.4%) 0 (0.0%) 8 (3.1%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 2 (0.8%) 3 (1.2%) 2 (0.8%) 0 (0.0%) 5 (2.0%) 12 (4.7%) 4 (1.6%) 0 (0.0%) 16 (6.3%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 2 (0.8%) 5 (2.0%) 3 (1.2%) 10 (3.9%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 2 (0.8%) 2 (0.8%) 5 (2.0%) 2 (0.8%) 2 (0.8%) 1 (0.4%) 5 (2.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 68 (26.8%) 51 (20.1%) 0 (0.0%) 119 (46.9%) 9 (3.5%) 3 (1.2%) 0 (0.0%) 12 (4.7%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 8 (3.1%) 7 (2.8%) 0 (0.0%) 15 (5.9%) 0 (0.0%) 5 (2.0%) 0 (0.0%) 5 (2.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 623

25 IFN/R C033*1 of 15 IFN/R n=253 0 (0.0%) 67 (26.5%) 186 (73.5%) 253 (100.0%) 14 (5.5%) 3 (1.2%) 2 (0.8%) 19 (7.5%) 11 (4.3%) 1 (0.4%) 2 (0.8%) 14 (5.5%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 3 (1.2%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 34 (13.4%) 8 (3.2%) 0 (0.0%) 42 (16.6%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 30 (11.9%) 7 (2.8%) 0 (0.0%) 37 (14.6%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 4 (1.6%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 24 (9.5%) 10 (4.0%) 1 (0.4%) 35 (13.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 8 (3.2%) 2 (0.8%) 0 (0.0%) 10 (4.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 6 (2.4%) 1 (0.4%) 0 (0.0%) 7 (2.8%) 12 (4.7%) 1 (0.4%) 0 (0.0%) 13 (5.1%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 13 (5.1%) 1 (0.4%) 15 (5.9%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 4 (1.6%) 0 (0.0%) 5 (2.0%) 0 (0.0%) 5 (2.0%) 1 (0.4%) 6 (2.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 70 (27.7%) 52 (20.6%) 0 (0.0%) 122 (48.2%) 3 (1.2%) 1 (0.4%) 0 (0.0%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 6 (2.4%) 12 (4.7%) 0 (0.0%) 18 (7.1%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 624

26 PEG/R C033*2 of 15 PEG/R n=254 2 (0.8%) 54 (21.3%) 198 (78.0%) 254 (100.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 6 (2.4%) 0 (0.0%) 6 (2.4%) 0 (0.0%) 7 (2.8%) 0 (0.0%) 7 (2.8%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 15 (5.9%) 2 (0.8%) 0 (0.0%) 17 (6.7%) 5 (2.0%) 0 (0.0%) 0 (0.0%) 5 (2.0%) 3 (1.2%) 2 (0.8%) 0 (0.0%) 5 (2.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 4 (1.6%) 4 (1.6%) 0 (0.0%) 8 (3.1%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 2 (0.8%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 15 (5.9%) 1 (0.4%) 0 (0.0%) 16 (6.3%) 12 (4.7%) 4 (1.6%) 0 (0.0%) 16 (6.3%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 3 (1.2%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 6 (2.4%) 1 (0.4%) 0 (0.0%) 7 (2.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 6 (2.4%) 1 (0.4%) 0 (0.0%) 7 (2.8%) 3 (1.2%) 0 (0.0%) 0 (0.0%) 3 (1.2%) 6 (2.4%) 1 (0.4%) 0 (0.0%) 7 (2.8%) 3 (1.2%) 2 (0.8%) 0 (0.0%) 5 (2.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 5 (2.0%) 6 (2.4%) 0 (0.0%) 11 (4.3%) 2 (0.8%) 2 (0.8%) 0 (0.0%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 625

27 IFN/R C033*2 of 15 IFN/R n=253 0 (0.0%) 67 (26.5%) 186 (73.5%) 253 (100.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 9 (3.6%) 0 (0.0%) 9 (3.6%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 3 (1.2%) 1 (0.4%) 0 (0.0%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 3 (1.2%) 0 (0.0%) 5 (2.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 27 (10.7%) 6 (2.4%) 0 (0.0%) 33 (13.0%) 3 (1.2%) 2 (0.8%) 0 (0.0%) 5 (2.0%) 3 (1.2%) 2 (0.8%) 0 (0.0%) 5 (2.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 3 (1.2%) 4 (1.6%) 0 (0.0%) 7 (2.8%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 18 (7.1%) 1 (0.4%) 0 (0.0%) 19 (7.5%) 17 (6.7%) 0 (0.0%) 0 (0.0%) 17 (6.7%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 12 (4.7%) 2 (0.8%) 0 (0.0%) 14 (5.5%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 9 (3.6%) 1 (0.4%) 0 (0.0%) 10 (4.0%) 7 (2.8%) 0 (0.0%) 0 (0.0%) 7 (2.8%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 6 (2.4%) 0 (0.0%) 0 (0.0%) 6 (2.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 3 (1.2%) 2 (0.8%) 11 (4.3%) 0 (0.0%) 13 (5.1%) 4 (1.6%) 1 (0.4%) 0 (0.0%) 5 (2.0%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 626

28 PEG/R C033*3 of 15 PEG/R n=254 2 (0.8%) 54 (21.3%) 198 (78.0%) 254 (100.0%) 79 (31.1%) 149 (58.7%) 1 (0.4%) 229 (90.2%) 15 (5.9%) 1 (0.4%) 0 (0.0%) 16 (6.3%) 14 (5.5%) 2 (0.8%) 0 (0.0%) 16 (6.3%) 105 (41.3%) 14 (5.5%) 0 (0.0%) 119 (46.9%) 4 (1.6%) 1 (0.4%) 0 (0.0%) 5 (2.0%) 20 (7.9%) 20 (7.9%) 0 (0.0%) 40 (15.7%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 3 (1.2%) 0 (0.0%) 0 (0.0%) 3 (1.2%) 6 (2.4%) 7 (2.8%) 0 (0.0%) 13 (5.1%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 2 (0.8%) 19 (7.5%) 40 (15.7%) 0 (0.0%) 59 (23.2%) 57 (22.4%) 27 (10.6%) 0 (0.0%) 84 (33.1%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 4 (1.6%) 2 (0.8%) 0 (0.0%) 6 (2.4%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 3 (1.2%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 4 (1.6%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 4 (1.6%) 7 (2.8%) 0 (0.0%) 11 (4.3%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 9 (3.5%) 6 (2.4%) 0 (0.0%) 15 (5.9%) 7 (2.8%) 0 (0.0%) 0 (0.0%) 7 (2.8%) 3 (1.2%) 1 (0.4%) 0 (0.0%) 4 (1.6%) 3 (1.2%) 1 (0.4%) 0 (0.0%) 4 (1.6%) 1 (0.4%) 3 (1.2%) 0 (0.0%) 4 (1.6%) 4 (1.6%) 2 (0.8%) 0 (0.0%) 6 (2.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 8 (3.1%) 0 (0.0%) 9 (3.5%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 627

29 IFN/R C033*3 of 15 IFN/R n=253 0 (0.0%) 67 (26.5%) 186 (73.5%) 253 (100.0%) 62 (24.5%) 173 (68.4%) 1 (0.4%) 236 (93.3%) 12 (4.7%) 3 (1.2%) 0 (0.0%) 15 (5.9%) 12 (4.7%) 3 (1.2%) 0 (0.0%) 15 (5.9%) bae (41.1%) 25 (9.9%) 0 (0.0%) 129 (51.0%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 3 (1.2%) 17 (6.7%) 33 (13.0%) 0 (0.0%) 50 (19.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 15 (5.9%) 11 (4.3%) 0 (0.0%) 26 (10.3%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 1 (0.4%) 4 (1.6%) 0 (0.0%) 5 (2.0%) 13 (5.1%) 49 (19.4%) 0 (0.0%) 62 (24.5%) 70 (27.7%) 36 (14.2%) 0 (0.0%) 106 (41.9%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 3 (1.2%) 3 (1.2%) 0 (0.0%) 6 (2.4%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 4 (1.6%) 0 (0.0%) 4 (1.6%) 3 (1.2%) 2 (0.8%) 0 (0.0%) 5 (2.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 3 (1.2%) 2 (0.8%) 0 (0.0%) 5 (2.0%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 2 (0.8%) 2 (0.8%) 7 (2.8%) 0 (0.0%) 9 (3.6%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 3 (1.2%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 15 (5.9%) 7 (2.8%) 0 (0.0%) 22 (8.7%) 8 (3.2%) 0 (0.0%) 0 (0.0%) 8 (3.2%) 3 (1.2%) 2 (0.8%) 0 (0.0%) 5 (2.0%) 1 (0.4%) 2 (0.8%) 0 (0.0%) 3 (1.2%) 1 (0.4%) 2 (0.8%) 0 (0.0%) 3 (1.2%) 1 (0.4%) 3 (1.2%) 0 (0.0%) 4 (1.6%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 4 (1.6%) 0 (0.0%) 4 (1.6%) 0 (0.0%) 4 (1.6%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 628

30 PEG/R C033*4 of 15 PEG/R n=254 2 (0.8%) 54 (21.3%) 198 (78.0%) 254 (100.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 2 (0.8%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 14 (5.5%) 4 (1.6%) 0 (0.0%) 18 (7.1%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 109 (42.9%) 38 (15.0%) 0 (0.0%) 147 (57.9%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 7 (2.8%) 0 (0.0%) 0 (0.0%) 7 (2.8%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 2 (0.8%) 1 (0.4%) 4 (1.6%) 0 (0.0%) 5 (2.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 15 (5.9%) 29 (11.4%) 0 (0.0%) 44 (17.3%) 30 (11.8%) 26 (10.2%) 0 (0.0%) 56 (22.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 8 (3.1%) 10 (3.9%) 0 (0.0%) 18 (7.1%) 28 (11.0%) 7 (2.8%) 0 (0.0%) 35 (13.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 3 (1.2%) 1 (0.4%) 0 (0.0%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 0 (0.0%) 3 (1.2%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 6 (2.4%) 4 (1.6%) 0 (0.0%) 10 (3.9%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 629

31 IFN/R C033*4 of 15 IFN/R n=253 0 (0.0%) 67 (26.5%) 186 (73.5%) 253 (100.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 6 (2.4%) 4 (1.6%) 0 (0.0%) 10 (4.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 109 (43.1%) 54 (21.3%) 0 (0.0%) 163 (64.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 8 (3.2%) 0 (0.0%) 0 (0.0%) 8 (3.2%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 2 (0.8%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 3 (1.2%) 0 (0.0%) 3 (1.2%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 5 (2.0%) 0 (0.0%) 6 (2.4%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 21 (8.3%) 33 (13.0%) 0 (0.0%) 54 (21.3%) 26 (10.3%) 34 (13.4%) 0 (0.0%) 60 (23.7%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 2 (0.8%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 4 (1.6%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 5 (2.0%) 7 (2.8%) 0 (0.0%) 12 (4.7%) 30 (11.9%) 19 (7.5%) 0 (0.0%) 49 (19.4%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 3 (1.2%) 2 (0.8%) 0 (0.0%) 5 (2.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 1 (0.4%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 3 (1.2%) 1 (0.4%) 0 (0.0%) 4 (1.6%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 4 (1.6%) 7 (2.8%) 0 (0.0%) 11 (4.3%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 1 (0.4%) 0 (0.0%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (0.4%) 0 (0.0%) 1 (0.4%) 6 (2.4%) 1 (0.4%) 0 (0.0%) 7 (2.8%) 2 (0.8%) 0 (0.0%) 0 (0.0%) 2 (0.8%) 630

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