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1 1039 報 告 婦人科腫瘍委員会 第 54 回治療年報 2006 年に治療した子宮頸癌, 子宮体癌, 卵巣悪性 境界悪性腫瘍の 5 年治療成績について 婦人科腫瘍委員会の第 54 回治療年報 (2006 年治療開始例 ) の報告をいたします. なお, 第 49 回治療年報より, 従来の直接法最小生存率 * による方法から Kaplan-Meier 法に変更しました. 追跡不能症例 (Lost to follow-up) が多いと治療成績の信頼性が低下するため, 予後追跡報告で追跡不能症例が 20% を超える施設のデータは治療成績の解析には用いないこととしています. 予後解析に使用された施設は, 施設名の左に がつけてあります. 加盟機関の先生方のご苦労に感謝申し上げ, また婦人科腫瘍委員会の全委員に御礼申し上げます. 今後とも何卒よろしくお願い申し上げます. 婦人科腫瘍委員会委員長青木大輔 子宮頸癌治療成績 Table A Table 1~8 Figure 1~10 5 年後の治療転帰項目別成績予後 5 年生存率 子宮体癌治療成績 Table A Table 1~8 Figure 1~10 5 年後の治療転帰項目別成績予後 5 年生存率 卵巣悪性腫瘍治療成績 Table A Table 1~6 Figure 1~9 5 年後の治療転帰項目別成績予後 5 年生存率 卵巣境界悪性腫瘍治療成績 Table A 5 年後の治療転帰 Table 1~6 項目別成績 * 最小生存率 : 直接法とは観察開始時点から一定の年限を経過した症例について生存者数を観察対象者数で割った値である. この場合, 消息不明例の取扱いによって 3 種類の生存率が計算される. すなわち, 消息不明例をすべて死亡とみなして計算する最小生存率, すべて生存とみなして計算する最大生存率, 消息不明例を対象から除外して計算する推定 ( 概算 ) 生存率の 3 種類である. ( 日本癌治療学会 癌規約総論, 金原出版,1991 より抜粋 ) 本報告に関するお問い合わせは婦人科腫瘍委員会にお願いいたします.
2 1040 日産婦誌 66 巻 3 号 A Institution B C D E F G H I J K no description Total No. Treated 子宮頸癌治療成績 Statement for the Year 2006, Inclusive, Cervix Table A. 5-Year Results, Stage I-IV no Evidence of the or without Other Malignant Tumor Intercurrent Cause of Death HOKKAIDO CANCER CENTER JR SAPPORO HOSP SAPPORO MED. UNIV HOKKAIDO UNIV KKR SAPPORO MED. CENTER ASAHIKAWA CITY HOSP ASAHIKAWA MED. COLL AOMORI PREF. CENTRAL HOSP HIROSAKI UNIV MISAWA CITY HOSP TOHOKU UNIV SENDAI MED. CENTER AKITA RED CROSS HOSP AKITA UNIV YAMAGATA PREF. CENTRAL HOSP YAMAGATA UNIV TSUCHIURA KYODO GENERAL HOSP KASUMIGAURA MED. CENTER TSUKUBA GAKUEN HOSP TSUKUBA UNIV HITACHI GENERAL HOSP TSUKUBA MED. CENTER TOCHIGI NATIONAL HOSP DOKKYO MED. UNIV SAISEIKAI UTSUNOMIYA HOSP ASHIKAGA RED CROSS HOSP JICHI MED. UNIV TOCHIGI CANCER CENTER GUNMA UNIV GUNMA PREF. CANCER CENTER SAITAMA SHAKAI HOKEN HOSP KOSHIGAYA MUNI. HOSP SAITAMA NATIONAL HOSP NATIONAL DEFENSE MED. COLL SAITAMA CANCER CENTER CHIBA UNIV NIPPON MED. SCH. CHIBA HOKUSOU HOSP MATSUDO CITY HOSP TOKYO DENTAL COLL. ICHIKAEA GENERAL HOSP JIKEI UNIV. KASHIWA HOSP JUNTENDO UNIV. URAYASU HOSP ASAHI CENTRAL HOSP KAMEDA MED. CENTER CHIBA CANCER CENTER NATIONAL INS. OF RADIOLOGICAL SCIENCES MITUI MEMORIAL HOSP NATIONAL CANCER CENTER JIKEI UNIV JUNTENDO UNIV TOKYO MED. DENT. UNIV NIPPON MED. SCH TOKYO UNIV TOKYO WOMENS MED. UNIV. MED. CENTER EAST JIKEI UNIV. KATSUSHIKA MED. CENTER Lost to follow-up
3 1041 A Institution B C D E F G H I J K no description Total No. Treated no Evidence of the or without Other Malignant Tumor Intercurrent Cause of Death TOKYO METRO. BOKUTOH HOSP NTT MED. CENTER TOKYO SHOWA UNIV TOHO UNIV. OMORI MED. CENTER RED CROSS MED. CENTER KOSEI CENTRAL HOSP KEIO UNIV NATIONAL CENTER FOR GLOBAL HEALTH AND MED TOKYO WOMENS MED. UNIV KOSEI HOSP TEIKYO UNIV NIHON UNIV MUSASHINO RED CROSS HOSP MACHIDA MUNI. HOSP JIKEI UNIV. 3RD HOSP NIPPON MED. SCH. TAMA NAGAYAMA HOSP TOKYO METRO. KOMAGOME HOSP KYOUNDO HOSP CANCER INST. HOSP TAMA-NAMBU CHIIKI HOSP KAWASAKI MUNI. HOSP NIPPON MED. SCH. MUSASHI KOSUGI HOSP KANTO ROSAI HOSP ST. MARIANNA UNIV YOKOHAMA ROSAI HOSP SHOWA UNIV. FUJIGAOKA HOSP KITAZATO UNIV YOKOHAMA CITY UNIV YOKOHAMA MINAMI KYOSAI HOSP ISEHARA KYODO HOSP TOKAI UNIV KANAGAWA CANCER CENTER YOKOHAMA CITY UNIV. MED. CENTER YAMANASHI PREF. CENTRAL HOSP UNIV. OF YAMANASHI NAGANO RED CROSS HOSP SHINSHU UNIV FUJI CITY GENERAL HOSP SHIZUOKA GENERAL HOSP NAGAOKA RED CROSS HOSP NIIGATA CANCER CENTER HOSP TOYAMA UNIV TOYAMA RED CROSS HOSP KANAZAWA MED. UNIV KANAZAWA MED. CENTER KANAZAWA UNIV FUKUI PREF. HOSP FUKUI UNIV FUKUI RED CROSS HOSP GIFU UNIV OGAKI MUNI. HOSP TOYOHASHI MUNI. HOSP RED CROSS NAGOYA DAIICHI HOSP NAGOYA MED. CENTER NAGOYA UNIV NAGOYA CITY UNIV FUJITA HEALTH UMIN AICHI MED. UNIV AICHI CANCER CENTER MIE PREF. GENERAL MED. CENTER Lost to follow-up
4 1042 日産婦誌 66 巻 3 号 A Institution B C D E F G H I J K no description Total No. Treated no Evidence of the or without Other Malignant Tumor Intercurrent Cause of Death YOKKAICHI MUNI. HOSP MIE UNIV ISE RED CROSS HOSP OHTSU RED CROSS HOSP SHIGA UNIV. OF MED. SCIENCE SHIGA MED. CENTER FOR ADULTS KYOTO 2ND RED CROSS HOSP KYOTO PREF. UNIV. OF MED KYOTO 1ST RED CROSS HOSP KYOTO UNIV KITANO HOSP OSAKA NATIONAL HOSP OSAKA POLICE HOSP OSAKA UNIV OSAKA MED. COLL KANSAI MED. UNIV KINKI UNIV OSAKA ROUSAI HOSP OSAKA MED. CENTER FOR CANCER AND CVD KOBE UNIV KOBE CITY MED. CENTER GENERAL HOSP KOBE MED. CENTER KANSAI ROSAI HOSP HYOGO MED. COLL TOYOOKA PUBLIC HOSP HIMEJI RED CROSS HOSP HIMEJI MED. CENTER HYOGO CANCER CENTER NARA PREF. NARA HOSP TENRI HOSP NARA MED. UNIV JAPAN RED CROSS WAKAYAMA MED. CENTER WAKAYAMA MED. UNIV TOTTORI PREF. CENTRAL HOSP TOTTORI UNIV SHIMANE UNIV SHIMANE PREF. CENTRAL HOSP KAWASAKI HOSP OKAYAMA SAISEIKAI GENERAL HOSP OKAYAMA UNIV KURASHIKI CENTRAL HOSP FUKUYAMA MED. CENTER ONOMICHI GENERAL HOSP HIROSHIMA CITY HOSP HIROSHIMA CITY ASA HOSP HIROSHIMA UNIV HIROSHIMA PREF. HOSP KURE MED. CENTER HIROSHIMA GENERAL HOSP HIGASHIHIROSHIMA MED. CENTER TOKUYAMA CENTRAL HOSP YAMAGUCHI RED CROSS HOSP YAMAGUCHI UNIV TOKUSHIMA UNIV TOKUSHIMA PREF. CENTRAL HOSP TAKAMATSU RED CROSS HOSP TAKAMATSU MUNI. HOSP KAGAWA PREF. CENTRAL HOSP SHIKOKU CANCER CENTER EHIME PREF. CENTRAL HOSP Lost to follow-up
5 1043 A Institution B C D E F G H I J K no description Total No. Treated no Evidence of the or without Other Malignant Tumor Intercurrent Cause of Death Lost to follow-up KOCHI HEALTH SCIENCES CENTER KOCHI UNIV UNIV. OCCUPATIONAL & ENVIRONMENTAL HEALTH KYUSHU MED. CENTER KYUSHU UNIV FUKUOKA UNIV FUKUOKA RED CROSS HOSP KURUME UNIV KYUSHU CANCER CENTER SAGA UNIV NAGASAKI MUNI. HOSP NAGASAKI UNIV RED CROSS NAGASAKI ATOMIC BOMB HOSP SASEBO KYOSAI HOSP KUMAMOTO MED. CENTER KUMAMOTO UNIV KUMAMOTO CITY HOSP OITA PREF. HOSP OITA UNIV MIYAZAKI PREF. HOSP MIYAZAKI UNIV KAGOSHIMA UNIV KAGOSHIMA CITY HOSP RYUKYU UNIV OKINAWA PREF. CHUBU HOSP Total
6 1044 日産婦誌 66 巻 3 号 Table 1. No. of Patients by Stage and Age Age ~19 20~29 30~39 40~49 50~59 60~69 70~79 80~ Total FIGO Stage No. % No. % No. % No. % No. % No. % No. % No. % No. % A A A not cl I B B B not cl not cl total A II B not cl total A III B not cl total A IV B not cl total Total
7 1045 Table 2. Type of Treatment FIGO Stage I II III IV Treatment Alone Surgery Rad. Chem.Immun. Rad. Other Chem.Immun. Rad. Other Hormon Hormon Chem.Immun. Hormon, Other Rad. Chem.Immun. Hormon, Other No. % No. % No. % No. % No. % No. % No. % No. % A A A not cl B B B not cl not cl total A B not cl total A B not cl total A B not cl total Total Treatment Alone Chem.Immun. Hormon Radiation Other Chem.Immun. Hormon, Other Chem.Immun. Hormon FIGO Stage No. % No. % No. % No. % No. % No. % No. % No. % No. % A A A not cl I B B B not cl not cl total A II B not cl total A III B not cl total A IV B not cl total Total Alone Other Alone Others Other Total
8 1046 日産婦誌 66 巻 3 号 Table 3. 5-Year Results, Treatment Started in year result No. of patients % no Evidence of the or without Other Malignant Tumor Intercurrent Cause of Death Lost to follow-up Total 2699 Table 4. 5-Year Survival by Stage, Treatment Started in 2006 FIGO Stage Patients treated 5-year survival No. % A A A not cl I B B B not cl not cl. 2 - A II B not cl. 0 - A III B not cl. 0 - A IV B not cl. 2 - Total Lost to follow-up 73/1401 (5.2%) 38/662 (5.7%) 26/414 (6.3%) 7/222 (3.2%) Table 5. 5-Year Survival by Histological Type, Treatment Started in 2006 Histological type Patients treated 5-year survival No. % % Squamous cell carcinoma Adenocarcinoma Adenosquamous carcinoma Others No description
9 1047 Table 6. 5-Year Survival by Stage and Histological Type, Treatment Started in 2006 FIGO Stage I II III IV Histology type Patients treated 5-year survival No. % % Squamous cell carcinoma Adenocarcinoma Adenosquamous carcinoma Others No description Squamous cell carcinoma Adenocarcinoma Adenosquamous carcinoma Others No description Squamous cell carcinoma Adenocarcinoma Adenosquamous carcinoma Others No description Squamous cell carcinoma Adenocarcinoma Adenosquamous carcinoma Others No description Table 7. 5-Year Survival by First Therapy, Treatment Started in 2006 FIGO Stage I II III IV Therapy Patients treated 5-year survival No. % % Surgery Radiation (Radiation alone) 10 (0.7) (90.0) Chemotherapy Others Surgery Radiation (Radiation alone) 26 (3.9) (56.0) Chemotherapy Others Surgery Radiation (Radiation alone) 38 (9.2) (30.3) Chemotherapy Others Surgery Radiation (Radiation alone) 36 (16.2) (14.3) Chemotherapy Others
10 1048 日産婦誌 66 巻 3 号 Table 8. 5-Year Survival by TNM Classification, Treatment Started in 2006 TNM Stage Patients treated 5-year survival No. % % T1a1 N0 M T1a2 N0 M T1b1 N0 M T1b2 N0 M T2a N0 M T2b N0 M T3a N0 M T3b N0 M T4 N0 M T1a1 N1 M T1b1 N1 M T1b2 N1 M T2a N1 M T2b N1 M T3a N1 M T3b N1 M T4 N1 M Any T Any N M
11 1049 Figure 1. Kaplan-Meier Estimated Overall Survival Curves of Cervical Cancer Patients by FIGO Stage, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank <.0001 Wilcoxon < Log (LR) <.0001 Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values FIGO Stage FIGO Stage Raw Tukey-Kramer I II <.0001 <.0001 I III <.0001 <.0001 I IV <.0001 <.0001 II III <.0001 <.0001 II IV <.0001 <.0001 III IV
12 1050 日産婦誌 66 巻 3 号 Figure 2. Kaplan-Meier Estimated Overall Survival Curves of Cervical Cancer Patients by Histological Type, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank <.0001 Wilcoxon < Log (LR) <.0001 Histological Type Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenosquamous carcinoma Adenosquamous carcinoma Others Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison Histological Type Adenosquamous carcinoma Others Squamous cell carcinoma Others Squamous cell carcinoma Squamous cell carcinoma p-values Raw Tukey-Kramer
13 1051 Figure 3. Kaplan-Meier Estimated Overall Survival Curves of Cervical Cancer Patients by FIGO Stage I Substage, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank <.0001 Wilcoxon < Log (LR) <.0001 Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values FIGO Stage FIGO Stage Raw Tukey-Kramer 1A1 1A < A1 1B A1 1B <.0001 < A2 1B A2 1B <.0001 < B1 1B <.0001 <.0001
14 1052 日産婦誌 66 巻 3 号 Figure 4. Kaplan-Meier Estimated Overall Survival Curves of Stage I Cervical Cancer Patients by Histological Type, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank Wilcoxon Log (LR) Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values Histological Type Histological Type Raw Tukey-Kramer Aenocarcinoma Adenosquamous carcinoma Adenocarcinoma Others Adenocarcinoma Squamous cell carcinoma Adenosquamous carcinoma Others Adenosquamous carcinoma Squamous cell carcinoma Others Squamous cell carcinoma <.0001 <.0001
15 1053 Figure 5. Kaplan-Meier Estimated Overall Survival Curves of Cervical Cancer Patients by FIGO Stage II Substage, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank Wilcoxon Log (LR)
16 1054 日産婦誌 66 巻 3 号 Figure 6. Kaplan-Meier Estimated Overall Survival Curves of Stage II Cervical Cancer Patients by Histological Type, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank Wilcoxon Log (LR) Histological Type Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenosquamous carcinoma Adenosquamous carcinoma Others Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values Histological Type Raw Tukey-Kramer Adenosquamous carcinoma Others Squamous cell carcinoma Others Squamous cell carcinoma Squamous cell carcinoma
17 1055 Figure 7. Kaplan-Meier Estimated Overall Survival Curves of Cervical Cancer Patients by FIGO Stage III Substage, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank Wilcoxon Log (LR)
18 1056 日産婦誌 66 巻 3 号 Figure 8. Kaplan-Meier Estimated Overall Survival Curves of Stage III Cervical Cancer Patients by Histological Type, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank <.0001 Wilcoxon < Log (LR) <.0001 Histological Type Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenosquamous carcinoma Adenosquamous carcinoma Others Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values Histological Type Raw Tukey-Kramer Adenosquamous carcinoma Others Squamous cell carcinoma Others Squamous cell carcinoma Squamous cell carcinoma <.0001 <.0001
19 1057 Figure 9. Kaplan-Meier Estimated Overall Survival Curves of Cervical Cancer Patients by FIGO Stage IV Substage, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank Wilcoxon Log (LR)
20 1058 日産婦誌 66 巻 3 号 Figure 10. Kaplan-Meier Estimated Overall Survival Curves of Stage IV Cervical Cancer Patients by Histological Type, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank Wilcoxon Log (LR) Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values Histological Type Histological Type Raw Tukey-Kramer Adenocarcinoma Adenosquamous carcinoma Adenocarcinoma Others Adenocarcinoma Squamous cell carcinoma Adenosquamous carcinoma Others Adenosquamous carcinoma Squamous cell carcinoma Others Squamous cell carcinoma
21 1059 A Institution B C D E F G H I J K no description Total No. Treated 子宮体癌治療成績 Statement for the Year 2006, Inclusive, Corpus Table A. 5-Year Results, Stage I-IV no Evidence of the or without Other Malignant Tumor Intercurrent Cause of Death HOKKAIDO CANCER CENTER JR SAPPORO HOSP SAPPORO MED. UNIV HOKKAIDO UNIV KKR SAPPORO MED. CENTER ASAHIKAWA CITY HOSP ASAHIKAWA MED. COLL HIROSAKI UNIV MISAWA CITY HOSP TOHOKU UNIV SENDAI MED. CENTER AKITA RED CROSS HOSP AKITA UNIV YAMAGATA PREF. CENTRAL HOSP YAMAGATA UNIV FUKUSHIMA MED. UNIV TSUCHIURA KYODO GENERAL HOSP KASUMIGAURA MED. CENTER TSUKUBA GAKUEN HOSP TSUKUBA UNIV HITACHI GENERAL HOSP TSUKUBA MED. CENTER TOCHIGI NATIONAL HOSP DOKKYO MED. UNIV SAISEIKAI UTSUNOMIYA HOSP ASHIKAGA RED CROSS HOSP JICHI MED. UNIV TOCHIGI CANCER CENTER GUNMA UNIV GUNMA PREF. CANCER CENTER SAITAMA SHAKAI HOKEN HOSP KOSHIGAYA MUNI. HOSP SAITAMA NATIONAL HOSP NATIONAL DEFENSE MED. COLL SAITAMA CANCER CENTER CHIBA UNIV NIPPON MED. SCH. CHIBA HOKUSOU HOSP MATSUDO CITY HOSP TOKYO DENTAL COLL. ICHIKAEA GENERAL HOSP JIKEI UNIV. KASHIWA HOSP JUNTENDO UNIV. URAYASU HOSP ASAHI CENTRAL HOSP KAMEDA MED. CENTER CHIBA CANCER CENTER NATIONAL INS. OF RADIOLOGICAL SCIENCES NATIONAL CANCER CENTER JIKEI UNIV JUNTENDO UNIV TOKYO MED. DENT. UNIV NIPPON MED. SCH TOKYO UNIV TOKYO WOMENS MED. UNIV. MED. CENTER EAST JIKEI UNIV. KATSUSHIKA MED. CENTER TOKYO METRO. BOKUTOH HOSP Lost to follow-up
22 1060 日産婦誌 66 巻 3 号 A Institution B C D E F G H I J K no description Total No. Treated no Evidence of the or without Other Malignant Tumor Intercurrent Cause of Death NTT MED. CENTER TOKYO SHOWA UNIV TOHO UNIV. OMORI MED. CENTER RED CROSS MED. CENTER KOSEI CENTRAL HOSP KEIO UNIV NATIONAL CENTER FOR GLOBAL HEALTH AND MED TOKYO WOMENS MED. UNIV KOSEI HOSP TEIKYO UNIV NIHON UNIV MUSASHINO RED CROSS HOSP MACHIDA MUNI. HOSP JIKEI UNIV. 3RD HOSP NIPPON MED. SCH. TAMA NAGAYAMA HOSP TOKYO METRO. KOMAGOME HOSP KYOUNDO HOSP CANCER INST. HOSP TAMA-NAMBU CHIIKI HOSP KAWASAKI MUNI. HOSP NIPPON MED. SCH. MUSASHI KOSUGI HOSP KANTO ROSAI HOSP ST. MARIANNA UNIV YOKOHAMA ROSAI HOSP SHOWA UNIV. FUJIGAOKA HOSP KITAZATO UNIV YOKOHAMA CITY UNIV YOKOHAMA MINAMI KYOSAI HOSP YAMATO MUNI. HOSP ISEHARA KYODO HOSP TOKAI UNIV KANAGAWA CANCER CENTER YOKOHAMA CITY UNIV. MED. CENTER YAMANASHI PREF. CENTRAL HOSP UNIV. OF YAMANASHI NAGANO RED CROSS HOSP SHINSHU UNIV FUJI CITY GENERAL HOSP SHIZUOKA GENERAL HOSP NAGAOKA RED CROSS HOSP NIIGATA CANCER CENTER HOSP TOYAMA UNIV TOYAMA RED CROSS HOSP KANAZAWA MED. UNIV KANAZAWA MED. CENTER KANAZAWA UNIV FUKUI PREF. HOSP FUKUI UNIV FUKUI RED CROSS HOSP GIFU UNIV OGAKI MUNI. HOSP TOYOHASHI MUNI. HOSP RED CROSS NAGOYA DAIICHI HOSP NAGOYA MED. CENTER NAGOYA UNIV NAGOYA CITY UNIV FUJITA HEALTH UMIN AICHI MED. UNIV AICHI CANCER CENTER Lost to follow-up
23 1061 A Institution B C D E F G H I J K no description Total No. Treated no Evidence of the or without Other Malignant Tumor Intercurrent Cause of Death MIE PREF. GENERAL MED. CENTER YOKKAICHI MUNI. HOSP MIE UNIV ISE RED CROSS HOSP OHTSU RED CROSS HOSP SHIGA UNIV. OF MED. SCIENCE SHIGA MED. CENTER FOR ADULTS KYOTO 2ND RED CROSS HOSP KYOTO PREF. UNIV. OF MED KYOTO 1ST RED CROSS HOSP KYOTO UNIV KITANO HOSP OSAKA CITY GENERAL HOSP OSAKA NATIONAL HOSP OSAKA POLICE HOSP OSAKA UNIV OSAKA MED. COLL KANSAI MED. UNIV OSAKA ROUSAI HOSP OSAKA MED. CENTER FOR CANCER AND CVD KOBE UNIV KOBE CITY MED. CENTER GENERAL HOSP KOBE MED. CENTER KANSAI ROSAI HOSP HYOGO MED. COLL TOYOOKA PUBLIC HOSP HIMEJI RED CROSS HOSP HIMEJI MED. CENTER HYOGO CANCER CENTER NARA PREF. NARA HOSP TENRI HOSP NARA MED. UNIV JAPAN RED CROSS WAKAYAMA MED. CENTER WAKAYAMA MED. UNIV TOTTORI PREF. CENTRAL HOSP TOTTORI UNIV SHIMANE UNIV SHIMANE PREF. CENTRAL HOSP KAWASAKI HOSP OKAYAMA SAISEIKAI GENERAL HOSP OKAYAMA UNIV KURASHIKI CENTRAL HOSP FUKUYAMA MED. CENTER ONOMICHI GENERAL HOSP HIROSHIMA CITY HOSP HIROSHIMA CITY ASA HOSP HIROSHIMA UNIV HIROSHIMA PREF. HOSP KURE MED. CENTER HIROSHIMA GENERAL HOSP HIGASHIHIROSHIMA MED. CENTER TOKUYAMA CENTRAL HOSP YAMAGUCHI RED CROSS HOSP YAMAGUCHI UNIV TOKUSHIMA MUNI. HOSP TOKUSHIMA UNIV TOKUSHIMA PREF. CENTRAL HOSP TAKAMATSU RED CROSS HOSP TAKAMATSU MUNI. HOSP Lost to follow-up
24 1062 日産婦誌 66 巻 3 号 A Institution B C D E F G H I J K no description Total No. Treated no Evidence of the or without Other Malignant Tumor Intercurrent Cause of Death KAGAWA PREF. CENTRAL HOSP SHIKOKU CANCER CENTER KOCHI HEALTH SCIENCES CENTER KOCHI UNIV UNIV. OCCUPATIONAL & ENVIRONMENTAL HEALTH KYUSHU MED. CENTER KYUSHU UNIV FUKUOKA UNIV FUKUOKA RED CROSS HOSP KURUME UNIV KYUSHU CANCER CENTER SAGA UNIV NAGASAKI MUNI. HOSP NAGASAKI UNIV RED CROSS NAGASAKI ATOMIC BOMB HOSP SASEBO KYOSAI HOSP KUMAMOTO MED. CENTER KUMAMOTO UNIV KUMAMOTO CITY HOSP OITA PREF. HOSP OITA UNIV MIYAZAKI PREF. HOSP MIYAZAKI UNIV KAGOSHIMA UNIV KAGOSHIMA CITY HOSP RYUKYU UNIV OKINAWA PREF. CHUBU HOSP Total Lost to follow-up
25 1063 Table 1. No. of Patients by Stage and Age Age ~19 20~29 30~39 40~49 50~59 60~69 70~79 80~ Total FIGO Stage No. % No. % No. % No. % No. % No. % No. % No. % No. % A B I C not cl total A II B not cl total A B III C not cl total A IV B not cl total Total
26 1064 日産婦誌 66 巻 3 号 Table 2. Type of Treatment FIGO Stage I II III IV Treatment A B C not cl total A B not cl total A B C not cl total A B not cl total Total Treatment Alone Rad. Rad. Chem.Immun. Rad. Chem.Immun. Other Chem.Immun. Rad. Other Hormon, Chem.Immun. Hormon Hormon Other Hormon, Other No. % No. % No. % No. % No. % No. % No. % No. % Alone Chem.Immun. Hormon Radiation Other Chem.Immun. Hormon, Other Surgery Chem.Immun. Hormon FIGO Stage No. % No. % No. % No. % No. % No. % No. % No. % No. % A B I C not cl total A II B not cl total A B III C not cl total A IV B not cl total Total Alone Other Alone Others Other Total
27 1065 Table 3. 5-Year Results, Treatment Started in year result No. of patients % no Evidence of the or without Other Malignant Tumor Intercurrent Cause of Death Lost to follow-up Total 3243 Table 4. 5-Year Survival by Stage, Treatment Started in 2006 FIGO Stage Patients treated 5-year survival No. % Lost to follow-up A I B C /2105(2.5%) not cl. 9 - A II B /266(3.0%) not cl. 2 - A III B C /658(3.7%) not cl. 3 - A IV B /214(7.9%) not cl. 6 - Total Table 5. 5-Year Survival by Stage and Histological Type, Treatment Started in 2006 FIGO Stage Ⅰ Ⅱ III IV Histology Patients treated 5-year survival No. % % Endometrioid type Serous, Mucinous, Clear cell type Others No description Endometrioid type Serous, Mucinous, Clear cell type Others No description Endometrioid type Serous, Mucinous, Clear cell type Others No description Endometrioid type Serous, Mucinous, Clear cell type Others No description
28 1066 日産婦誌 66 巻 3 号 Table 6. 5-Year Survival by Stage and Grade, Treatment Started in 2006 FIGO Stage Ⅰ Ⅱ III IV Grade Patients treated 5-year survival No. % % Grade Grade Grade Not Graded Grade Grade Grade Not Graded Grade Grade Grade Not Graded Grade Grade Grade Not Graded Table 7. 5-Year Survival by Histological Type and Grade, Treatment Started in 2006 Histology Endometrioid type Serous, Mucinous, Clear cell type Others Grade Patients treated 5-year survival No. % % Grade Grade Grade Not Graded Grade Grade Grade Not Graded Grade Grade Grade Not Graded
29 1067 Table 8. 5-Year Survival by TNM Classification, Treatment Started in 2006 TNM Stage Patients treated 5-year survival No. % % T1a N0 M T1b N0 M T1c N0 M T2a N0 M T2b N0 M T3a N0 M T3b N0 M T3c N0 M T4 N0 M T1a N1 M T1b N1 M T1c N1 M T2a N1 M T2b N1 M T3a N1 M T3b N1 M T3c N1 M T4 N1 M Any T AnyN M
30 1068 日産婦誌 66 巻 3 号 Figure 1. Kaplan-Meier Estimated Overall Survival Curves of Corpus Cancer Patients by FIGO Stage, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank <.0001 Wilcoxon < Log (LR) <.0001 Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values FIGO Stage FIGO Stage Raw Tukey-Kramer I II <.0001 <.0001 I III <.0001 <.0001 I IV <.0001 <.0001 II III <.0001 <.0001 II IV <.0001 <.0001 III IV <.0001 <.0001
31 1069 Figure 2. Kaplan-Meier Estimated Overall Survival Curves of Corpus Cancer Patients by Grade of Differentiation, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank <.0001 Wilcoxon < Log (LR) <.0001 Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values Grade Grade Raw Tukey-Kramer Grade 1 Grade <.0001 <.0001 Grade 1 Grade <.0001 <.0001 Grade 1 Not Graded <.0001 <.0001 Grade 2 Grade <.0001 <.0001 Grade 2 Not Graded <.0001 <.0001 Grade 3 Not Graded
32 1070 日産婦誌 66 巻 3 号 Figure 3. Kaplan-Meier Estimated Overall Survival Curves of Corpus Cancer Patients by FIGO Stage I Substage, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank <.0001 Wilcoxon < Log (LR) <.0001 Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values FIGO Stage FIGO Stage Raw Tukey-Kramer IA IB IA IC <.0001 <.0001 IB IC
33 1071 Figure 4. Kaplan-Meier Estimated Overall Survival Curves of Stage I Corpus Cancer Patients by Grade of Differentiation, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank <.0001 Wilcoxon < Log (LR) <.0001 Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values Grade Grade Raw Tukey-Kramer Grade 1 Grade <.0001 <.0001 Grade 1 Grade <.0001 <.0001 Grade 1 Not Graded <.0001 <.0001 Grade 2 Grade Grade 2 Not Graded Grade 3 Not Graded
34 1072 日産婦誌 66 巻 3 号 Figure 5. Kaplan-Meier Estimated Overall Survival Curves of Corpus Cancer Patients by FIGO Stage II Substage, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank Wilcoxon Log (LR)
35 Figure 6. Kaplan-Meier Estimated Overall Survival Curves of Stage II Corpus Cancer Patients by Grade of Differentiation, Treatment Started in Test of Equality over Strata Test DF Pr > Log-rank Wilcoxon Log (LR) Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values Grade Grade Raw Tukey-Kramer Grade 1 Grade Grade 1 Grade Grade 1 Not Graded Grade 2 Grade Grade 2 Not Graded Grade 3 Not Graded
36 1074 日産婦誌 66 巻 3 号 Figure 7. Kaplan-Meier Estimated Overall Survival Curves of Corpus Cancer Patients by FIGO Stage III Substage, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank Wilcoxon Log (LR) Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values FIGO Stage FIGO Stage Raw Tukey-Kramer IIIA IIIB < IIIA IIIC IIIB IIIC
37 1075 Figure 8. Kaplan-Meier Estimated Overall Survival Curves of Stage III Corpus Cancer Patients by Grade of Differentiation, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank <.0001 Wilcoxon < Log (LR) <.0001 Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values Grade Grade Raw Tukey-Kramer Grade 1 Grade Grade 1 Grade <.0001 <.0001 Grade 1 Not Graded <.0001 <.0001 Grade 2 Grade Grade 2 Not Graded <.0001 <.0001 Grade 3 Not Graded
38 1076 日産婦誌 66 巻 3 号 Figure 9. Kaplan-Meier Estimated Overall Survival Curves of Corpus Cancer Patients by FIGO Stage IV Substage, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank Wilcoxon Log (LR)
39 1077 Figure 10. Kaplan-Meier Estimated Overall Survival Curves of Stage IV Corpus Cancer Patients by Grade of Differentiation, Treatment Started in 2006 Test of Equality over Strata Test DF Pr > Log-rank <.0001 Wilcoxon Log (LR) <.0001 Adjustment for Multiple Comparisons for the Log-rank Test Strata Comparison p-values Grade Grade Raw Tukey-Kramer Grade 1 Grade Grade 1 Grade Grade 1 Not Graded <.0001 <.0001 Grade 2 Grade Grade 2 Not Graded Grade 3 Not Graded
40 1078 日産婦誌 66 巻 3 号 A Institution B C D E F G H I J K no description Total No. Treated 卵巣悪性腫瘍治療成績 Statement for the Year 2006, Inclusive, Malignant Ovarian Tumor Table A. 5-Year Results, Stage I-IV no Evidence of the or without Other Malignant Tumor Intercurrent Cause of Death HOKKAIDO CANCER CENTER JR SAPPORO HOSP SAPPORO MED. UNIV HOKKAIDO UNIV KKR SAPPORO MED. CENTER ASAHIKAWA CITY HOSP ASAHIKAWA MED. COLL HIROSAKI UNIV MISAWA CITY HOSP TOHOKU UNIV SENDAI MED. CENTER AKITA RED CROSS HOSP AKITA UNIV YAMAGATA PREF. CENTRAL HOSP YAMAGATA UNIV FUKUSHIMA MED. UNIV TSUCHIURA KYODO GENERAL HOSP KASUMIGAURA MED. CENTER TSUKUBA GAKUEN HOSP TSUKUBA UNIV HITACHI GENERAL HOSP TSUKUBA MED. CENTER TOCHIGI NATIONAL HOSP DOKKYO MED. UNIV SAISEIKAI UTSUNOMIYA HOSP ASHIKAGA RED CROSS HOSP JICHI MED. UNIV TOCHIGI CANCER CENTER GUNMA PREF. CANCER CENTER SAITAMA SHAKAI HOKEN HOSP KOSHIGAYA MUNI. HOSP SAITAMA NATIONAL HOSP NATIONAL DEFENSE MED. COLL SAITAMA CANCER CENTER CHIBA UNIV NIPPON MED. SCH. CHIBA HOKUSOU HOSP MATSUDO CITY HOSP TOKYO DENTAL COLL. ICHIKAEA GENERAL HOSP JIKEI UNIV. KASHIWA HOSP JUNTENDO UNIV. URAYASU HOSP ASAHI CENTRAL HOSP KAMEDA MED. CENTER CHIBA CANCER CENTER MITUI MEMORIAL HOSP NATIONAL CANCER CENTER JIKEI UNIV JUNTENDO UNIV TOKYO MED. DENT. UNIV NIPPON MED. SCH TOKYO UNIV TOKYO WOMENS MED. UNIV. MED. CENTER EAST JIKEI UNIV. KATSUSHIKA MED. CENTER TOKYO METRO. BOKUTOH HOSP NTT MED. CENTER TOKYO Lost to follow-up
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