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12 agents inhibiting fungal squalene epoxidase, Scinence, 224: , Ryder NS, Dupont MC: Inhibition of squalene epoxidase by allylamine antimycotic compounds, Biochem J, 230: , Ryder NS: Selective inhibition of squalene epoxidation by allylamine antimycotic agents, Microbial Cell Wall Synthesis and Autolysis, (Nombela C Ed), Elsevier Science, Amsterdam, 1984, Ryder NS: Effect of allylamine antimycotic agents on fungal sterol biosynthesis measured by sterol side-chain methylation, J Gen Microbiol, 131: , Stutz A SF and related compounds Synthetic methods; in Proc 13th Int Congr Chemother (Spitzy KH and Karrer K eds), TOM 6, Vienna, Austria, 1983, 116/5-116/8 2. Shadomy S, Espinel-Ingroff A, Gebhart RJ In vitro studies with SF86-327, a new orally active allylamine derivative, J Med Ver Mycol, , Davies RR: "Griseofulvin", antifungal Chemotherapy (Speller DCE, ed), Jone Wiley and 4. Petranyi G, Meingassner JG, Mieth H Activity Sons Ltd, Chichester , 1980 of terbinafine in experimental fungal infec- 18. Hantschke D, Gutz H:Griseofulvinresistenz, tions of laboratory animals. Antimicrobial Z. Hautkr, 56: , 1981 Agents and Chemotherapy, , 19. Artis WM, Odle BM, John HE et al:griseofulvin-resistant 1987 dermatophytosis correlates with in vitro resistance, Arch Dermatol, 117:16-19, Schuster I, Ryder NS: Allylamine-mode and selectivity 6. Petranyi G, Ryder NS, Stutz A : Allylamine and action compared to azole antifun- derivatives; New class of synthetic antifungal gals and biological fate in mammalian orga-
13 nisims, J Dermatol Treat 1 Suppl, 2:7-9, 1990 dose-finding trial of oral SF in volunteers 21. Jensen JC:Clinical pharmacokinetics of terbinafine (Lamisil). Clin Exp Dermatol, 14: , Meith H, Petranyi G:Preclinical evaluation of terbinafine in vivo, Clin Exp Dermatol, 14 : Stephen A:Double blind, placebo-controlled, 107, 1989
14 Investigation of Clinical Usefulness of Terbinafine Tablet at Low Dose In Patients with Extensive Tinea Corporis \ Nobuhiko Higashi Departmet of Dermatology, Sakai Municipal Hospital Shukuin-cho, Nishi, Sakai, Osaka 590, Japan Akinobu Shoji Department of Dermatology, Osaka Kaisei Hospital Kichiro Oka Section of Dermatology, Nagaoka Red Cross Hospital Chiaki Nishiyama Department of Dermatology, Nihon University Nerima Hikarigaoka Hospital Hiroshi Hanyaku Depatment of Dermatology, Ogikubo Hospital Ken Noma Department of Dermatology, Nippon Steel Corporation Yawata Works Hospital Key words : terbinafine-clinical usefulness-low dose-extensive tinea corporis Usefulness of oral antifungal agent, Terbinafine tablet, at a daily dose of 62.5mg(low dose) was investigated in patients with extensive tinea corporis. Seventeen cases were employed for the assessment of both the efficacy and usefulness ratings, and 21 cases for the safety rating. The ratings for negative of fungi and for the improvement rating of skin symptoms were 47.1% and 76.5%, respectively. The ratings for both efficacy and usefulness were 52.9%. Adverse reactions observed were one case each of gastrointestinal symptom and headache, but no abnormal finding in laboratory tests was observed. The result of this study suggests that Terbinafine at a daily dose of 62.5mg did not reduce the occurrence of adverse reactions as compared with that of 125mg, while sufficient treatment effects could not be obtained. Considering the result of the dosage increase to 125mg, a daily dose of 125mg Terbinafine is superior to that of 62.5mg.
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