untitled
|
|
|
- ようた おおかわち
- 5 years ago
- Views:
Transcription
1 Shinichiro Okamoto MD, PhD Keio University School of Medicine Tokyo Japan
2
3
4
5
6 vincristine) Berberidaceae etoposide VP-16)
7 MRD PCR ( CR) ( CR)
8 AML Study n Ind Consol % 3 5yr CALGB 474 DA/HiDACx3 or HiDACx1, E, CTX or diaziquone, M GAMLCG 535 TAD, HAM/TAD HOVON 253 DA, AMSA A/ME ALFA 345 DA MA AMSA A; MEC ALLG 298 ICE ICE or IcEx JALSG 1,057 IA or DA MA, DA, ACR-A, A-triple-V or HiDACx
9
10 / P P PI3K/Akt
11 Mylotarg (gemtuzumab ozogamicin) gemtuzumab ozogamicin internalization CD33 calicheamicin DNA
12 ATP BCR-ABL 9 9 BCR-ABL (q+) Ph (22q-) Effector X Y abl bcr Effector bcr-abl
13 CML Imatinib IRIS Study % CML ASH 2009
14 Affinity of Three TKIs to Abl Imatinib Nilotinib Dasatinib
15 III AP24534 II Dasatinib Nilotinib AP SRC ABL1 ABL1 SRC ABL1 VEGF T315I T315I E255V E255K V V299L F317L E255K V Y253F H Q252H F359V T315I E255V
16
17 AML Farnesyl tranferase FLT3 P CD33 Tipifarnib PKC412 CEP-701 Bortezomib Decitabine Azacytidine Clofarabine Cloretazine Bcl-2 Oblimeresen sodium Zosuquidar GO
18 P15 P21 P15 P21 MAP P15 P210 AKT0 P15 P21 MAP MAP MAP C-KIT RAS ERK ERK PKC ERK IL ERK STAT BCR-ABL
19 ( Ph + ALL N= (3 100 (3 + (N=25 Probability (%) % % % % Including one CR after Salvage Tx + Imatinib P < P < Blood 2005; 105:
20
21
22 JMDP) 600 Nations
23 / Probability % % 37.2% % 57.5% 46.7% 17.5% % % BBMT 14: , 2008, BMT 39; , 2007
24 AML LFS OS % 100 % 100 Leukemia-free survival Transplant group No transplant group Overall survival Transplant group No transplant group P= P= Leukemia 23: , 2009
25 Painting its brighter future
26 GVHD
27 UVAR XTS TM or CELLEX TM Photopheresis Systems
28 Extracorporeal Photopheresis (ECP)
29 A Multicenter Prospective Phase 2 Randomized Study of Extracorporeal Photopheresis for Treatment of Chronic Graft-Versus-Host Disease Median % Change in Steroid Dose By 12W 50% reduction of PSL is achieved in 20.8% ECP group vs 6.4% Control p <0.04 ECP Control Probability of a Response / p < ECP Control W2 W4 W6 W8 W10 W12 Study Week Study Week Blood 2008; 112:
30 ECP Complete and Partial Response Rate % % 65% 12 50% 43% 36% 27% 12% 7% Complete and Partial Response Rate % % 70% 24 50% 50% 47% 42% 29% 26% Original Randomized Non-ECP Cross-over Open-Label ECP Study Original Randomized ECP Crossover Open-Label ECP Study
31
32 Nitch
33 G-CSF CXCR4 CD44 HA SDF- VLA-4 VCAM-1 c-kit KL MMP9 NE+ CG Plerixafor (AMD3100)
34 AMD3100 Washington University School of Medicine MD Anderson Cancer Center Dana Farber Cancer Institute Washington University School of Medicine Multicenter Multicenter Phase II. HLA plerixafor Phase I/II. plerixafor Phase I/II. AML MEC plerixafor Phase I/II. CLL plerixafor Phase I. plerixafor
35 Shh AMD3100 AMD3465 SDF-1 VEGF C CXCR4 FLT4 Notch Cell cycling p27 Kip1 PI3K/Akt & MAPK signaling mtor S6 kinase Bcl-2 expression Sorafeni b Sorafenib FLT3 KIT KL CD44 CD62L VLA-4 Natalizuma b BIO5192 VCAM-1 Osteopontin Fibronectin Collagen Hyaluronin PSGL GMI-1070 Blood 2009; 113:
36 Thank you for your attention!!
PowerPoint Presentation
1 Cutaneous T- cell lymphoma) 2) 2001 WHO - - - PS LDH soluble IL- B 38.5 C 10 International Prognostic Index IPI International prognostic factor and index Prognostic factor >60 LDH > PS 2-4 Stage III
山形PhALL座談会_MF.indd
Hematology Today 特別企画 VII 山形 Ph+ALL 座談会 Current Status and Future Perspectives in the Treatment for Ph+ALL 司 会 大本英次郎 出席者佐藤伸二 木村淳 加藤裕一 本間りこ コメンテーター太田秀一 213 7 チロシンキナーゼ阻害薬 (TKI) 登場以前の Philadelphia 染色体陽性急性リンパ性白血病
Understanding Stem Cell Transplant 2007
Understanding Stem Cell Transplant IMF International Myeloma Foundation 12650 Riverside Drive, Suite 206 North Hollywood, CA 91607 USA Telephone: 800-452-CURE (2873) (USA & Canada) 818-487-7455 Fax: 818-487-7454
PowerPoint プレゼンテーション
* ** 117,320 70,293 109,140 49,830 93,402 45,744 60,986 31,875 47,318 28,829 45,367 18,186 29,025 12,838 27,822 11,970 20,734 10,823 19,994 10,336 * 2007 ** 2011 65% 25% 9 DNA P53, ATM G1 S G2 G1 M 1
Major Histocompatibility Complex 2018; 25 (2): 抄録集 2 HLA A 3 128
Major Histocompatibility Complex 2018; 25 (: 128 138 抄録集 2018 4 14 A 3 128 MHC 2018; 25 ( HLA 2013 10.5 10 8 12 10 8 2016 CD34 + HLA NC 10 8 CD34 + CD34 + 10 6 NC10.5 2013.Apr 2014.Mar NC11 2014.Apr 2016.Jun
食道がん化学放射線療法後のsalvage手術
2006 2 17 52 Daly JM, et al. J Am Coll Surg 2000;190:562-573 Esophageal Cancer: Results of an American College of Surgeons Patient Care Evaluation Study Daly JM, et al. J Am Coll Surg 2000;190:562-573
CEO 2017.10.30 Agenda Agenda ) 2000 2000 10 ~ ~ GLP: Good Laboratory Practice GCP: Good Clinical Practice GMP: Good Manufacturing Practice GPSP: Good Post-marketing Study 1 10,000 Practice GLP GMP GCP
cm H.11.3 P.13 2 3-106-
H11.3 H.11.3 P.4-105- cm H.11.3 P.13 2 3-106- 2 H.11.3 P.47 H.11.3 P.27 i vl1 vl2-107- 3 h vl l1 l2 1 2 0 ii H.11.3 P.49 2 iii i 2 vl1 vl2-108- H.11.3 P.50 ii 2 H.11.3 P.52 cm -109- H.11.3 P.44 S S H.11.3
untitled
( ) - 1 - - 2 - 38% 26% A) Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma 124 (J Clin Oncol 7: 126-131, 1989) 124 95 29 II 1 2,000mg/m 2 x 4 8g/m
I? 3 1 3 1.1?................................. 3 1.2?............................... 3 1.3!................................... 3 2 4 2.1........................................ 4 2.2.......................................
20 15 14.6 15.3 14.9 15.7 16.0 15.7 13.4 14.5 13.7 14.2 10 10 13 16 19 22 1 70,000 60,000 50,000 40,000 30,000 20,000 10,000 0 2,500 59,862 56,384 2,000 42,662 44,211 40,639 37,323 1,500 33,408 34,472
- 2 -
- 2 - - 3 - (1) (2) (3) (1) - 4 - ~ - 5 - (2) - 6 - (1) (1) - 7 - - 8 - (i) (ii) (iii) (ii) (iii) (ii) 10 - 9 - (3) - 10 - (3) - 11 - - 12 - (1) - 13 - - 14 - (2) - 15 - - 16 - (3) - 17 - - 18 - (4) -
2 1980 8 4 4 4 4 4 3 4 2 4 4 2 4 6 0 0 6 4 2 4 1 2 2 1 4 4 4 2 3 3 3 4 3 4 4 4 4 2 5 5 2 4 4 4 0 3 3 0 9 10 10 9 1 1
1 1979 6 24 3 4 4 4 4 3 4 4 2 3 4 4 6 0 0 6 2 4 4 4 3 0 0 3 3 3 4 3 2 4 3? 4 3 4 3 4 4 4 4 3 3 4 4 4 4 2 1 1 2 15 4 4 15 0 1 2 1980 8 4 4 4 4 4 3 4 2 4 4 2 4 6 0 0 6 4 2 4 1 2 2 1 4 4 4 2 3 3 3 4 3 4 4
1 (1) (2)
1 2 (1) (2) (3) 3-78 - 1 (1) (2) - 79 - i) ii) iii) (3) (4) (5) (6) - 80 - (7) (8) (9) (10) 2 (1) (2) (3) (4) i) - 81 - ii) (a) (b) 3 (1) (2) - 82 - - 83 - - 84 - - 85 - - 86 - (1) (2) (3) (4) (5) (6)
untitled
Data cleaning Original datan=8479 NCC/ptkgN=7958 NCC10x10E628 8139 NCC/kgPage 1-2) Covariate cleaningcovariate Page Page5-8 Kaplan-Meier method, Log-rank, Cox hazard model Overall survival Cumulative incidence
1 (1) 3 4 (2) 5 () 30 35 40 45 50 55 60 410 519 599 975 1,176 1,362 1,840 250 298 426 691 735 829 693 865 1,287 1,838 2,209 2,718 2,776 3,361 888 1,061 1,448 1,598 1,849 2,157 2,214 1,324 1,172 964 808
- 1 - - 2 - - 3 - - 4 - - 5 - - 6 - - 7 - - 8 - - 9 - - 10 - - 11 - - 12 - - 13 - - 14 - - 15 - - 16 - - 17 - - 18 - - 19 - - 20 - - 21 - - 22 - - 23 - - 24 - - 25 - - 26 - - 27 - - 28 - - - - 29 - - 30
03慢性骨髄性白血病CML.indd
慢* 59 病CML略語一覧 Ⅰ クリニカルクエスチョン一覧 Ⅱ 略語一覧 慢性骨髄性白血病 CML CQ 1 小児 CML の標準的治療は何か CQ 2 小児 CML 治療における造血幹細胞移植の役割は何か CML (Chronic Myelocytic Leukemia, 慢性骨髄性白血病 ) TKI (Tyrosine Kinase Inhibitor, チロシンキナーゼ阻害薬 ) CHR (Complete
Rinku General Medical Center
Rinku General Medical Center 4860 100 1620 Ann Intern Med. 1966; 64: 328 40 CHOP 63 1 83 J Clin Oncol. 1998; 16: 20065-69 Febrile Neutropenia IDSA(Infectious Diseases Society of America) 2002 Guidelines
日本消化器外科学会雑誌第29巻第9号
Table 1 Oligonucleotide primers used for RT-PCR and internal probes used for Southern blot hybridization Cytokine Primer Sequence (5'-3') 5' 3' Internal probe s' 3' Internal probe 5' 3' Internal probe
52-2.indb
Jpn. J. Health Phys., 52 (2) 55 60 (2017) DOI: 10.5453/jhps.52.55 * 1 * 2 * 2 * 3 * 3 2016 10 28 2017 3 8 Enhancement of Knowledge on Radiation Risk Yukihiko KASAI,* 1 Hiromi KUDO,* 2 Masahiro HOSODA,*
untitled
twatanab@oncoloplan.com http://www.oncoloplan.com I II - III IV Fig 3. Survival curves overall and according to response Bruzzi, P. et al. J Clin Oncol; 23:5117-5125 25 Copyright merican Society of Clinical
untitled
1988 2000 2002 2004 2006 2008 IFN Lamivudine Adefovir Entecavir 1 Total number 560 Sex (male/female) 424/136 Age (years)* 38 (15-68) Duration of treatment (weeks)* 26 (1-592) Follow-up time (years) 75(05-21
分子標的薬アプデート 2018
Primary imatinib, 2002-2008 (CML IV) 5-year survival 93% n = 2830 Survival probability IFN or SCT, 1997-2008 (CML IIIA) 5-year survival 71% IFN or SCT, 1995-2008 (CML III) 5-year survival 63% IFN, 1986-2003
ii
HPSI Hosei University Policy Science Institute i ii iii iv Cool Japan) - 1 - - 2 - - 3 - - 4 - - 5 - - 6 - - 7 - - 8 - CSBS - 9 - - 10-21 - 11 - - 12 - - 13 - - 14 - - 15 - - 16 - - 17 - - 18 - - 19 -
16 MHC 2018; 25 (1) 参加費 1 2, , ,000 会議等 :00 13: :00 13: :20 会場地図 TEL JR 350 m 57
Major Histocompatibility Complex 2018; 25 (1): 56 82 抄録集 16 2018 3 3 7 2 4 43 TEL 06 6962 7001 594 1101 840 TEL 0725 56 1220 56 16 MHC 2018; 25 (1) 参加費 1 2,000 2 1,000 3 3,000 会議等 1 3 3 13:00 13:10 2 3
3 6 6 8 5 5 0 4 3 4 4 0,000 3 ID ID ID 4 7 9 :5 4 5 60-8048 NACOS TEL: 075-45-366 FAX: 075-45-366 E-mail: jiao@nacos.com 3. Power Point PC 0 5. Power Point PC 7 3 3. 3 5 PC PC PC Windows Power Point USB
スライド 1
第 2 回新薬開発合同シンポジウム わが国からの新薬開発を目指して ~ 医療イノベーションをどう実現するか? 2012 年 11 月 16 日東京ステーションコンファレンス II. ポストゲノム時代の新薬開発を考える 世界における抗がん剤開発の現状 長浜バイオ大学 / がん支援 化学療法基盤支援活動班 水上民夫 抗がん剤開発 : 過去 15 年間の変遷 がん遺伝子産物をメインターゲットとする分子標的抗がん剤が30
Clinical Study of Effect of Intrathecal Use of Alpha-tocopherol on Chronic Vasospasm Hirotoshi Sano, Motoi Shoda, Youko Kato, Kazuhiro Katada, Youichi
Clinical Study of Effect of Intrathecal Use of Alpha-tocopherol on Chronic Vasospasm Hirotoshi Sano, Motoi Shoda, Youko Kato, Kazuhiro Katada, Youichi Shinomiya and Tetsuo Kanno Department of Neurosurgery,
CHEMOTHERAPY APR. 1984
VOL.32 S-3 CHEMOTHERAPY dihydro-4-oxo-7-(1-piperazinyl)-1, 8-naphthyridine- CHEMOTHERAPY APR. 1984 VOL.32 S-3 CHEMOTHERAPY Table 1 Implantation rates and post- implantation survival rates in females mated
エッセー
5.13................................... 3 5.14........................................ 9 5.15.................................. 12 5.16................................ 15 5.17..................... 18 5.18...................................
第５７巻２号／投稿規定・目次・表２・奥付・背
Feature articlesdiet in a society with a growing elderly population and a low birth rate Original The problems of breastfeeding Kazuhisa Maeda, Ryuji Mitani, Satoko Endo, Yoshika Saijo, and Toshihiro
ito.dvi
1 2 1006 214 542 160 120 160 1 1916 49 1710 55 1716 1 2 1995 1 2 3 4 2 3 1950 1973 1969 1989 1 4 3 3.1 3.1.1 1989 2 3.1.2 214 542 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27
cladribine 2-CdA ADA DCF HCL IFN- MTD LD50 LD90 DLT MDACC RWJPRI NHL ATL CLL 2-CdATP 5 -NT dckase (2-chloro-2 -deoxyadenosine) adenosine deaminase deoxycoformycin( ) hairy cell leukemia - (interferon alfa)
Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection
Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection Table 1. Bacterial cell counts in feces of mice infected with Esclwrichia coli O 157: H7 NK2 before and during oral dosing with fosfomycin
% 11.1% +6.% 4, % %+12.2% 54,16 6.6% EV7, ,183 Copyright 216 JAPAN POST GROUP. All Rights Reserved. 1
216 3 216 5 13 848+4.4% 11.1% +6.% 4,853 495 +2.6% 1 +11.6%+12.2% 54,16 6.6% EV7,829 2 7,183 Copyright 216 JAPAN POST GROUP. All Rights Reserved. 1 15.3 16.3 16.3 11,692 96,57 5.5 % 4,926 4,115 16.5 %
サイトメトリー12-1.indd
Cell Growth Inhibition and Apoptosis in Cancer Cells Kazuki Omoteyama, Shoichi Inoue and Alaa-eldin Salah-eldin Department of Environmental Medicine and Informatics, Graduate School of Environmental Earth
2 The Bulletin of Meiji University of Integrative Medicine 3, Yamashita 10 11
1-122013 1 2 1 2 20 2,000 2009 12 1 2 1,362 68.1 2009 1 1 9.5 1 2.2 3.6 0.82.9 1.0 0.2 2 4 3 1 2 4 3 Key words acupuncture and moxibustion Treatment with acupuncture, moxibustion and Anma-Massage-Shiatsu
(2009) 1... / 1 ( ) / 1 ( ) / 1 ( ), 2 ( )
212009................................................ 2............................................ 115 (2009) 1... / 1 ( )........................................... 4 2... / 1 ( )......................................
BE0005 TS-1/ InVivoMab anti-human LFA-1α (CD11a) mouse IgG , ,000 BE0005 TS-1/ InVivoMab anti-human LFA-1α (CD11a) mous
Bio X Cell 社価格表 (2018 年 4 月 ) < 株式会社シン コーポレーション > Bio X Cell 社価格表 (2018 年 4 月 ) ご注文ごとに別途取扱手数料 (2( 万円 税別 ) を申し受けます 大学向け価格でのご購入には アカデミックプライス適用申込書のご提出が必須となります 品番クローン品名イソタイプ 容量 (mg) 大学向希望小売価格 ( 円 ) 税別 希望小売価格
44 4 I (1) ( ) (10 15 ) ( 17 ) ( 3 1 ) (2)
(1) I 44 II 45 III 47 IV 52 44 4 I (1) ( ) 1945 8 9 (10 15 ) ( 17 ) ( 3 1 ) (2) 45 II 1 (3) 511 ( 451 1 ) ( ) 365 1 2 512 1 2 365 1 2 363 2 ( ) 3 ( ) ( 451 2 ( 314 1 ) ( 339 1 4 ) 337 2 3 ) 363 (4) 46
骨髄異形成症候群に対する 同種造血幹細胞移植の現状と課題
第 36 回造血幹細胞移植委員会 (H25.2.4) 資料 5 第 36 回厚生科学審議会疾病対策部会造血幹細胞移植委員会 日本造血細胞移植学会 (JSHCT) 移植医療の現場からの提言 日本造血細胞移植学会理事長 岡本真一郎 我が国における非血縁者間造血幹細胞移植数 2000 1800 1600 1400 1200 1000 800 600 400 200 非血縁者間骨髄移植非血縁者間臍帯血移植
PrmryCellCltrガイド_0620.indd
初代細胞培養製品ガイド HEK HEKa C-005-5C [1Vial (>500k cells)] HEKa-APF C-021-5C [1Vial (>500k cells)] Epilife in vitro 2 Epilife 60µM CaCl 2 HEKn C-001-5C [1Vial (>500k cells)] HEKn-APF C-020-5C [1Vial (>500k cells)]
112 54 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 Apr. 2013 8 2005 3 10 8 2012 6 7 B 2 NTT 2012 6
Apr. 2013 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 111 53 8 8 1. Ph-ALL Liposomal amphotericin B 1 2. CBT MCFG L-AMBAML 2 112 54 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 Apr. 2013 8 2005 3 10 8 2012 6
CAR-T実施
Building a Clinical CAR-T Program - Jichi Medical University Experience l l l Anti-CD3/28 mabs & IL-2: 29% Anti-CD3/28 beads: 66% Retroviral: 41% Lentiviral: 54% T-Flasks: 22% Static Culture Bags: 35%
i ii i iii iv 1 3 3 10 14 17 17 18 22 23 28 29 31 36 37 39 40 43 48 59 70 75 75 77 90 95 102 107 109 110 118 125 128 130 132 134 48 43 43 51 52 61 61 64 62 124 70 58 3 10 17 29 78 82 85 102 95 109 iii
Studies on the Antigens Expressed on Trophoblasts Related to MLR-blocking Antibodies Shigenori GOTO Department of Obstetrics and Gynecology, Niigata University School of Medicine (Director: Prof. Shoshichi
untitled
COLAK Mehmed 11000 305 305 180 10000 9000 8000 160 140 120 7000 100 6000 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 80 GH IGF-1 GH GH 5 4 3 2 1 0 2 3 4 5
告では DNR も IDR もさらに高い CR 率 (75~80% vs 79~82%) と DFS 率 (25~44% vs 26~30%) が報告されており meta-analysis の報告と異なって両者間に差を認めていない これは 欧米での DNR の総投与量が 135~150mg/m 2
急性骨髄性白血病の治療 :AML201(110920) このような疾患については直接治療に当たることは無いが プライマリ ケア医にとって全く関係 のない領域は無いと思う 日本人における急性白血病の治療に関する RCT を読んでみた 基本的知識が無いので 論文を読む前に 基本的事項をお勉強 急性骨髄性白血病 (AML) は 診断時に患者体内に 10 12 個程度 ( 重量で約 1kg) の白血病細胞があると考えられ
untitled
THE JOURNAL OF THE JAPAN MEDICAL CONFERENCE ON MAGNETISM 32 2007 11 09 55 10 00 20 10 1 10 00 10 30 2 10 30 11 00 3 11 00 11 30 4 11 30 12 00 12 00 13 00 5 13 00 13 30 1 2 3 6 13 30 14 00 1 2 3 NeurometerNS3000
IonTorrentPGM_appnote_0319.indd
Ion PGM Heterogeneity * 1 * 1 * 2 * 2 * 2 * 2 * 2 * 1 *1 * 2 DNA DNA DNA ArcturusXT LCM Laser Capture Microdissection LCM A Workflow for Cancer Profiling Applied Biosystems ViiA7 PCR qpcr QC Assay Ion
89 91 93 95 97 99 101 103 105 107 109 111 113 115 H 117 119 l l 121 l l 123 125 127 129 l l l l 131 kl kl kl kl 133 135 137 139 141 143 145 147 149 151 153 155 157 159
株式会社日清製粉グループ本社 第158期中間事業報告書
C O N T E N T S...1...3...5...7...9...11...12...13...14 1 2 3 4 3.7% 5.8% 8.5% 70,100kL 81.2% 0.8% 25 20 15 10 5 0 9.18 9.54 9.74 9.62 9.65 9.71 21.04 21.97 22.44 22.23 8.54 22.31 22.45 20.41 15 12 9 6
untitled
19CRC/2009.8.8-9 T0 T1 T2 T3 T4 M0 N0 M1 19CRC 2009.8.8 1 2 N1 N2 N3 Stage 0 Stage I Stage IIA Stage IIB Stage IIIA Stage IIIB Stage IIIC Stage IV Tis 3 4 5 6 1 19CRC/2009.8.8-9 7 8 Subtype of Breast Cancer
CHEMOTHERAPY APRIL 1992 Table 2. Concentration of meropenem in human prostatic fluid Table 1. Background of 21 chronic complicated UTI cases * NB + BPH, NB + Kidney tumor, NB + Kidney tuberculosis Table
endo.PDF
MAP 18 19 20 21 3 1173 MAP 22 700800 106 3000 23 24 59 1984 358 358 399 25 12 8 1996 3 39 24 20 10 1998 9,000 1,400 5,200 250 12 26 4 1996 156 1.3 1990 27 28 29 8 606 290 250 30 11 24 8 1779 31 22 42 9
Arthroscopic Treatment for Painful Bennett Lesions of the Shoulder in Baseball Players by M. Yoneda and K. Hayashida Department of Orthopaedic Surgery
Arthroscopic Treatment for Painful Bennett Lesions of the Shoulder in Baseball Players by M. Yoneda and K. Hayashida Department of Orthopaedic Surgery, Osaka Kosei-Nenkin Hospital K. Izawa and S. Wakitani
橡
TP T-13i AST ALT ALP Y CTP LOH CHE CRP 8.7 id 0.4 mg/d 21 AWL 131U/L 257 LU/L 12 111/L 234 11J/L 344 IU/L 0.30 mid No K a BUN ORE UA 142 meq/1 4.3 meqa 108 meqa 15.8 met! 0.71 mg/di 5.0 mg/d CEA 5_5 n8/m1
ABSTRACT The movement to increase the adult literacy rate in Nepal has been growing since democratization in 1990. In recent years, about 300,000 peop
Case Study Adult Literacy Education as an Entry Point for Community Empowerment The Evolution of Self-Help Group Activities in Rural Nepal Chizu SATO Masamine JIMBA, MD, PhD, MPH Izumi MURAKAMI, MPH Massachusetts
星医会51号.indb
1 , / / / / / / / / / / / / / / / / / /,, / / / /// /// / / / / / / / // / CBT / / / / / / 2 / / / / / /. / / / / / / / / POS / / / / / / / / /,,, CBT 3 / / / / / / / / 4 5 ARDS ? 6 CT MRI PET/CT 7 8 MESS
BTR 6110BTR CTC CTC CTC-HER2-1 -
0-1. 6110BTR 6110BTR CTC CTC CTC-HER2-1 - 0-2. 0-3. 0-4. 0-5. 0-6. 0-7. - 2 - - 3-0-8. tsurutani_j@dotd.med.kindai.ac.jp ykodera@med.kindai.ac.jp ...- 1-0-1.... - 1-0-2....- 2-0-3....- 2-0-4....- 2-0-5....-
平成１４年度 本態性多種化学物質過敏状態の調査研究 研究報告書
226 227 µ 228 Ω 229 230 0 ppb 2000ppb DG subthreshold (µa) 91 ± 59 86 ± 68 max stim. (µa) 755 ± 287 n=37 678 ± 300 max PS (mv) 8.7 ± 3.9 7.7 ± 4.3 n=61 CA1 subthreshold (µa) 36 ± 26 32 ± 13 max stim. (µa)
GIS GIS m 2m 5m 1 1 2,3,5 6 7,8 9, y = a 1 x + a 1 a 1 a y x 85ha 2m2mha 52m 2m GIS ArcView
Bull. Kitakyushu Mus. Nat. Hist. Hum. Hist., Ser. A, 5: 3338, March 31, 27 The forecast of the environmental changes in the urban green spaces by using the index of the degree of naturalness in vegetation
i ii ( ) ( ) ( ) 462,891 525,032 502,164 230,636 CD CD 1 1 2 2 3 3 4 4 5 5 6 6 7 7 8 8 9 9 10 10 11 10 12 11 13 11 14 12 15 12 16 13 16 14 17 15 18 15 18 16 19 17 20 17 18 19
14 D033 CR:16 15 E015 CR:18 16 E060 CR:15 17 D038 18 E059 19 E062 20 E063 21 E066 22 E064 23 E065 24 d031 25 E053 26 E048 27 E049 28 B009 29 D039 30 D
No QUEST CR 0 E051 1 E092 2 E093 3 E098 4 E099 5 D040 6 E100 7 E014 CR:14 ( 8 E010 9 E109 10 E045 11 E044 12 E028 13 E043 1 14 D033 CR:16 15 E015 CR:18 16 E060 CR:15 17 D038 18 E059 19 E062 20 E063 21
１
10 1113 14 1516 1719 20 21 22 2324 25 2627 i 2829 30 31 32 33 3437 38 3941 42 4344 4547 48 4950 5152 53 5455 ii 56 5758 59 6061 iii 1 2 3 4 5 6 7 8 9 10 PFI 30 20 10 PFI 11 12 13 14 15 10 11 16 (1) 17
untitled
2303 16 2 9 1 14 5 31 (423) 1 (4), (6) C55H84ClN17O21S3 HCl (BLM-A2) 1487.47 11 2 1 4 104 2 14 5 31 [ ] ( ) ( ) 1. 15mg 30mg( ) 5 20mL 1 5mg( ) 2. 3 15mg 30mg( ) 5mL 1mg( ) 1mL 3. 5mg 15mg( ) 4. 1 2 1
-1 - -2 - -3 - -4 - -5 - -6 - -7 - -8 - -9 - - 10 - -11 - - 12 - - 13 - - 14 - - 15 - - 16 - - 17 - - 18 - - 19 - - 20 - - 21 - - 22 - - 23 - - 24 - - 25 - - 26 - - 27 - - 28 - - 29 - - 30 - - 31 - - 32
