DementiaPhantomTestmanual
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1 F FDG PET 4 PET 2018/10/ PET(PET/CT) ( ) D ( X CT ) ( X CT ) PET DICOM header PET D D PET %contrast PET ROI (Coefficient of Variation: CV) c 1 / 19 petcamera@jsnm.org
2 ( ) A. 17 B D D PET D D D PET ROI ( : : ) PET ROI ROI PET ROI uroi mean D D ( 20 MBq) c 2 / 19 petcamera@jsnm.org
3 1. ( ) 18 F FDG PET DICOM (1) PET DICOM header PET DICOM header DICOM header (2) PET PET(PET/CT) PET ( ) ( % ) PET(PET/CT) PET(PET/CT) 2.2. ( ) ( ) 2.3. PET 3D (Fig. 1) [1] (Fig. 3) 2 Table 1, Table 2 3D 4 (Table 1, Fig. 2) 3. PET 3D 20 MBq 30 ( 3.1.5) 3D MBq 30 c 3 / 19 petcamera@jsnm.org
4 Table 1: 3D = 170 mm* = 205 mm* mm 1200 ml *... Figure 2: 3D Figure 1: 3D PET Table 2: = 320 mm = 170 mm = 300 mm = 160 mm 6,032 ml* *... 6,032 ml Figure 3: c 4 / 19 petcamera@jsnm.org
5 ( 3.2.5) D 3D 2 3D (Fig. 4) 3D 3D 90 3 (Fig. 4) ( 3.1.5, 3.2.5) ( 3.1.1, 3.2.1) Figure 4: 3D D 3D 18 F FDG PET F-FDG 3D (A H ) Eqn. 1 ( ) Tm A H = 20 exp ln(2) [MBq] (1) ln(2) e 2 T m [min] (T m ) 90 3D c 5 / 19 petcamera@jsnm.org
![(A H ) Eqn. 2 ( ) 90 A H = 20 exp 109.8 ln(2) = 35.3 [MBq] (2) 20 MBq 3D 3.1.2. 3D 3D 3D [2] 18 F ( 35.3 MBq) PET [2] 3.1.3. 3D PET(PET/CT) 3D 3D PET(PET/CT) (Fig.](/docs-images/93/114228998/images/6-0.jpg "5) X CT CT Figure 5: 3D 3.1.4. ( X CT ) PET X CT PET/CT X CT 3.1.5. 3D 20 MBq ±5% 30 3 PET PET c 6 / 19 petcamera@jsnm.org")
6 (A H ) Eqn. 2 ( ) 90 A H = 20 exp ln(2) = 35.3 [MBq] (2) 20 MBq 3D D 3D 3D [2] 18 F ( 35.3 MBq) PET [2] D PET(PET/CT) 3D 3D PET(PET/CT) (Fig. 5) X CT CT Figure 5: 3D ( X CT ) PET X CT PET/CT X CT D 20 MBq ±5% 30 3 PET PET c 6 / 19 petcamera@jsnm.org
7 ( 4.1) (Table 5) PET PET ( 6) ( ) iterative update( ) [3 5] (2mm ) [6, 7] 3.2. PET F-FDG (A C ) Eqn. 3 ( ) Tn A C = 20 exp ln(2) [MBq] (3) ln(2) e 2 T n [min] (T n ) 30 (A C ) Eqn. 4 ( ) 30 A C = 20 exp ln(2) = 24.2 [MBq] (4) 20 MBq F ( 24.2 MBq) ( ) PET(PET/CT) PET(PET/CT) (Fig. 6) X CT CT c 7 / 19 petcamera@jsnm.org
8 Figure 6: ( X CT ) PET X CT PET/CT X CT MBq ±5% 30 3 PET PET ( 4.1) (Table 5) PET D ( 3.1.6) PET (PET/CT X CT ) PET [Bq/mL] [Bq/cc] PET 3D ( 3.1.5) ( 3.2.5) PET 18 F FDG PET (Table 5) 4.2. PET c 8 / 19 petcamera@jsnm.org
9 3D ( 3.1.5) ( 3.2.5) PET(PET/CT) Table 3 Table 3: i HBP01 Brain CYL01 Brain ii ID JSNM H JSNM C ( + + ) iii BrainShisetsuNinsyo iv cm 160 cm* v 60.5 kg 60 kg* vi fluorodeoxyglucose vii 6588 sec min viii (Branching Fraction) ix ( ) x ( ) xi (PET ) xii Brain Hoffman Brain Pool xiii ( ) xiv (pixel size) xv ( )... HBP01 CYL01... PET * DICOM 1) 5.1. DICOM header DICOM header header 5.2. PET 18 F FDG PET PET ( ) ( ) ( ) ( 4.1) D 3D PET 1) DICOM PACS c 9 / 19 petcamera@jsnm.org
10 2) 3 3 3D PET (1) (PET ) (2) 3D PET (3) (4) PET Invert Gray scale (5) = = 10% (Fig. 7) 3) (6) 3D PET (Fig. 7) 3 (Fig. 8) (7) (FWHM) D PET %contrast 3D PET (ROI) 4) 3D PET ROI (1) 3D PET (2) 3D PET 4 1 ROI(Fig. 9) [8] ROI (3) ROI ROI Figure 7: 3D PET %contrast 3D PET ( 5.2) %contrast Eqn. 5 %contrast = GM P /WM P 1 GM d /WM d 1 100[%] (5) GM P WM P PET ROI GM d ROI WM d ROI 2) 3) SEAD J J ADNI FDG-PET 4) J ADNI PET QC ROI (Fig. 9) ROI c 10 / 19 petcamera@jsnm.org
11 Figure 8: PET PET ROI ( 5.2.6) ( 5.2.7) PET ROI PET Fig mm 2 ROI( 13 mm ROI 17 ROI mm 12 ROI 40mm +40mm (Fig. 11) Fig cm 2 ROI( 65 mm ROI) PET ROI( 5.2.5) (uroi mean ) Eqn. 6 uroi mean (uroi T OT ) c 11 / 19 petcamera@jsnm.org
12 Figure 9: ROI ( : : ) uroi T OT = n i=1 uroi mean,i (6) n uroi mean,i ROI n ROI 51 5) ROI uroi mean ROI uroi T OT (Fig. 13) uroi T OT ( uroi mean ) Eqn. 7 uroi mean = ( ) uroimean 1 uroi T OT (7) (SD uroi ) Eqn (Coefficient of Variation: CV) SD uroi = 1 n ( uroi mean,i ) n 1 2 (8) PET ROI( 5.2.5) Eqn. 9 (CV) 5) (1+4+12) 3 = 51 i=1 c 12 / 19 petcamera@jsnm.org
13 CV = SD n nroi mean 100% (9) SD n ROI(nROI) nroi mean nroi Figure 10: PET ROI (a) -40 mm (b) 0 mm (c) +40 mm Figure 11: 3 ROI Figure 12: PET ROI 6. J ADNI [10] c 13 / 19 petcamera@jsnm.org
14 6.1. 3D PET ( 5.2) 8 mm PET PET ( 5.2) 6.2. J ADNI [6,10] (1) PET (%contrast) 3D PET ( 5.2) %contrast 55% (2) ( uroi mean ) PET ( 5.2) ROI ( uroi mean ) (SD uroi ) SD uroi uroi mean ±5% ROI (Fig. 13) (3) (CV) PET ( 5.2) 15 % Figure 13: uroi mean c 14 / 19 petcamera@jsnm.org
15 ( ) F 0.6% 11 C 3.5% 1% 7.2. ( ) /3 1/ PET ( 6) c 15 / 19 petcamera@jsnm.org
16 [1] Hoffman EJ, Culer PD, Digby WM, et al: 3 D phantom to simulate cerebral blood flow and metabolic images for PET. IEEE Trans Nucl Sci. 1990; 37(2): [2] : PET.,,,,,,,.,, 2016: , [3] Jaskowiak CJ, Bianco JA, Perlman SB, et al: Influence of reconstruction iterations on 18 F FDG PET/CT standardized uptake values. J Nucl Med. 2005; 46(3): [4] Panin VY, Kehren F, Michel C, et al: Fully 3-D PET reconstruction with system matrix derived from point source measurements. IEEE Trans Med Imaging. 2006; 25(7): [5] Yokoi T, Shinohara H, Onishi H: Performance evaluation of OSEM reconstruction algorithm incorporating three-dimensional distance-dependent resolution compensation for brain SPECT: A simulation study. Ann Nucl Med. 2002; 16(1): [6] Ikari Y, Nishio T, Miya Y, et al: Head motion evaluation and correction for PET scans with 18 F FDG in the Japanese Alzheimer s disease neuroimaging initiative (J-ADNI) multi-center study. Ann Nucl Med. 2012; 26(7): , 6.2 [7] Akamatsu G, Ikari Y, Nishio T, et al: Optimization of image reconstruction conditions with phantoms for brain FDG and amyloid PET imaging. Ann Nucl Med. 2016; 30(1): [8] Ikari Y, Akamatsu G, Nishio T, et al: Phantom criteria for qualification of brain FDG and amyloid PET across different cameras. EJNMMI Phys. 2016; 3: [9] Hays MT, Segall GM: A mathematical model for the distribution of fluorodeoxyglucose in humans. J Nucl Med. 1999; 40(8): Table 4 [10] Iwatsubo T. Japanese Alzheimer s disease neuroimaging initiative: present status and future. Alzheimer s Dementia. 2010; 6(3): , 6.2, Table 4 [11] Lin KJ, Hsu WC, Hsiao IT, et al: Whole-body biodistribution and brain PET imaging with [ 18 F]AV 45, a novel amyloid imaging agent a pilot study. Nucl Med Biol. 2010; 37(4): Table 4 [12] Nelissen N, Van Laere K, Thurfjell L, et al: Phase 1 study of the Pittsburgh compound B derivative 18 F Flutemetamol in healthy volunteers and patients with probable Alzheimer s disease. J Nucl Med. 2009; 50(8): Table 4 [13] Rowe CC, Ackerman U, Browne W, et al: Imaging of amyloid beta in Alzheimer s disease with 18 F BAY , a novel PET tracer: proof of mechanism. Lancet Neurol. 2008; 7(2): Table 4 [14] Piramal Healthcare and SCETI. Information of 18 F-Florbetaben clinical trials. Table 4 [15] PET ; 68(6): c 16 / 19 petcamera@jsnm.org
17 A. PET PET 18 F FDG PET ( PET ) PET ( PET ) PET PET PET (Table 4) (Table 5) Table 4: 18 F FDG 185 MBq MBq; [9] 11 C PiB 555 MBq MBq; J ADNI [10] 18 F Florbetapir 370 MBq MBq; [11] 18 F Flutemetamol 185 MBq MBq; [12] 18 F Florbetaben 300 MBq MBq; [13, 14] Table 5: 3D ( 20 MBq) 18 F FDG C PiB F Florbetapir F Flutemetamol F Florbetaben c 17 / 19 petcamera@jsnm.org
18 B. 2 3D PET J ADNI PET(PET/CT) 12 PET/CT 4 7% 5% PET/CT 3 [15] Fig.3 B, C, F PET/CT 18 F FDG PET c 18 / 19 petcamera@jsnm.org
19 ver Florbetaben ROI c 19 / 19 petcamera@jsnm.org
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核 撮像法ガイド
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