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2 ,889 99, , , ,031 8,952 13,261 16,443 14,464 17,948 % ,037 8,848 10,927 9,231 12,422 % ,575 12,027 6,805 8,913 11,544 (4,229) 412 (1,806) (4,926) (7,187) ,439 4,999 3,987 4,357 10,531 11,807 12,495 13,964 11,059 % ,612 1,291 1,668 1,952 6,576 3,799 2,810 2,458 2,363 2,738 ROE % ROA% , , , , ,968 96, , , , ,099 % , , , , , % , % % % % ROE 10.0% 2.0

3 120,000 90,000 90,889 99, , , ,031 20,000 15,000 17,948 16,443 14,464 13,261 15,000 12,000 12,422 10,927 9,231 8,848 9,000 60,000 10,000 8,952 6,000 30,000 5,000 3,000 2, ROE CSR

4 NFLX AP2 S NFLX 1993 FLRX HES 1976 HES NFLX 1984 NFLX 1986 FLRX F GFLX 1998 P&G

5 HOPE100 Aim for Health Of People and our Enterprises HOPE HOPE Kyorin USA, Inc. 100% 2002 Kyorin Europe GmbH 100% GFLX 2004 ActivX Biosciences, Inc. 100% % mg 4mg mg SkyePharmaFlutiform Merz Neramexane 2010 DS50% 2011 Almirall Aclidinium Bromide 0.1mg 2012 MSD 0.5% S.A g

6 HOPE100 1 HOPE100 1 StrategyOrganization Performance3 S O Strategy Organization P Performance ,067 1,

7 HOPE100 HOPE HOPE100 No HOPE HOPE

8 Q Answer: % 6% , % 20.8% % % MC PC ,

9 Answer: 02 3 MC1 Q Answer: , KRP g FC HOPE R&D Q3 HOPE

10 Q4 Answer: 04 NO.1 Q5 Answer:

11 Q6 Answer: 06 30% 30% % % ,400 1,200 * * Q7 Answer: HOPE100 HOPE100 9

12 MR MSD

13 HOPE HOPE100 1 P.12 P.14 GMP Good Manu- facturing Practice P.16 FC MR 11

14

15 R&D OJT R&D 3 13

16 GMP Good Manufacturing Practice

17 3 OJT QDC* * QDC QQualityDDeliveryCCost 15

18 MR FCMR MR MR MRMR MRMR 2012 MRPC MR MR KRP

19 1g 2013 MR 2013 MR MR MR MR 2 3 MR MR5 MR MR FC MR 17

20 FC KRP-108KRP-AB1102KRP-AB1102F3 COPD COPD KRP- 108KRP-AB1102 KRP-AB1102F R&D KRP-108 KRP-108 KRP-108 FC 4 No.1 FC KRP-AM1977Y KRP-AM1977X KRP-AB1102F KRP-AB1102 KRP-108 COPD 1,000 1,400 4,100 77,000 1,700 MR

21 mg10mg 0 4mg5mg mg OD 0.1mg mg500mg 50%5% DS 50% mg500mg 1g1g mg FUL

22 FC KRP-108 KRP-209 KRP-AB1102KRP- AB1102F4 FC MSD LG S.A. SPIMACO* * SPIMACO Saudi Pharmaceutical Industries & Medical Appliances Corporation

23 Ph KRP-108 ICS 2LABA 08 4 Ph KRP-AB1102 COPD M Genuair ( ) MSD 13 4 KRP KRP-AB POCPhPh KRP-209 NMDA KRP-AB1102F M3LAMA LABA KRP-203 IBD S1P 06 2 IDB KRP-AM1977X KRP-AM1977Y MRSA KRP-209 Ph KRP-AB1102F PhPh KRP-203 IBD S1P 06 2IDB POC

24 HOPE100 CSR

25 http // company/governance.shtml B R B R 3 23

26 HOPE

27

28 CSR CSR PRTR CO2 20,000 15,000 10,000 5, * 2008 *

29 4. NOx SOx 5. ph BOD SS OHSAS ISO14001 OHSAS ISO OHSAS , kg

30 120,000 90,000 60,000 90,889 99, , , ,031 30,000 18,000 12,000 6, n n n n , ,000 30,000 20,000 10, ,952 n ,261 n n 8.8 8, , ,927 n ROE , ,422 9, ,948 ROE % % % 6% , % % S.A % % % 1, % % 37.5%

31 % % % % % (%) 103, ,031 3, ,926 40,133 3, ,306 66, ,842 48,949 (2,892) (5.6) 13,964 11,059 (2,904) (20.8) 14,464 17,948 3, (88) (10.1) (5) (8.5) 15,262 18,603 3, ,231 12,422 3, (%) 9,231 12,422 3, ,843 1, , ,000 90,000 96, , , , ,911 9,871 14,265 4, , , % , % , %2.2 ROE ROE % (%) 99, ,265 8, ,822 46, , ,968 9, ,385 22,897 (487) (2.1) 4,086 2,970 (1,115) (27.3) 27,471 25,868 (1,603) (5.8) 117, ,985 9, ,113 1, , ,099 10, , ,968 9,

32 20,000 10,000 10, ,027 12,439 11,544 8,913 6,805 4,575 4,999 3,987 4, (4,229) n n n (1,806) (4,926) (7,187) (%) 8,913 11,544 2, (4,926) (7,187) (2,261) (45.9) (7,412) (5,132) 2, ,210 22,543 (667) (2.9) 2013 HOPE (%) 107, , ,948 18, ,422 12,

33 PL IT IT 31

34 ,615 21,370 45,067 46,555 7,372 11,667 11,016 11, ,089 7,694 2,340 2,773 2,774 6,013 (58) (53) 99, ,265 28,222 30,306 (18,888) (19,790) 9,333 10,515 15,827 16,668 (13,331) (13,897) 2,495 2,770 1,619 2, (65) (78) ,071 6,690 7,071 (5,719) (5,940) 971 1,131 14,544 18, ,040 24, ,144 1,438 1,642 1,690 (421) (123) 30,431 27,577 45,822 46, , ,

35 ,043 8,556 3,159 1, ,111 3,356 3,110 3, ,802 5,962 23,385 22, ,949 1, ,086 2,970 27,471 25, ,752 4, , ,856 (318) (323) 117, , ,293 (267) (180) 269 2, , , , ,968 33

36 , ,031 36,926 40,133 66,306 66,897 51,842 48,949 14,464 17, ,275 18, ,262 18,603 5,179 5, ,031 6,181 9,231 12,422 9,231 12, ,231 12, ,738 (34) ,843 9,871 14,265 9,871 14,

37 ,752 4,752 4,752 4, , ,797 (3,362) (3,362) 9,231 12,422 5,868 9, , ,856 (304) (318) (13) (4) (13) (4) (318) (323) 112, ,931 (3,362) (3,362) 9,231 12,422 (13) (4) 5,854 9, , ,985 (137) , , ,293 (232) (267) (34) 87 (34) 87 (267) (180) (370) , , , , ,201 (3,362) (3,362) 9,231 12,422 (13) (4) 640 1,843 6,494 10, , ,099 35

38 ,262 18,603 2,363 2, (7) (302) (110) 211 (816) (1,010) 8 1 (26) (39) (340) (308) (1) (25) 7 (2,474) (1,480) (374) 800 (1,809) (486) (238) (144) 3,451 (2,956) 15,098 15, (48) (21) (6,505) (4,623) 8,913 11,544 (822) (1,328) 1,057 1,139 (799) (5,995) 2,402 (1,686) (5,972) 25 0 (357) (344) (7,427) (3,501) 5,121 6,853 (36) (441) (4,926) (7,187) (3,840) (1,675) (43) (70) (328) (386) (30) (12) (2) (3,357) (3,357) (7,412) (5,132) (29) 108 (3,454) (667) 26,665 23,210 23,210 22,

39 ,140 14,938 8,259 10, ,584 2, ,958 84, ,514 83,265 90,099 99, ,504 99,112 89,504 99,112 90,099 99, ,139 15,654 2,650 2,476 3,489 13, ,523 13, ,515 13, ,414 12,973 37

40 % % % % % Kyorin USA, Inc. 50 US$ 100% 500 Frank W. Burr Boulevard, Teaneck, New Jersey 07666, U.S.A Kyorin Europe GmbH 5 EURO 100% Kaiserstrasse 8, Frankfurt am Main, Germany ActivX Biosciences, Inc. 1US$ 100% N. Torrey Pines Rd., La Jolla, CA 92037, U.S.A %

41 URL ,947,628 5, % 4.91% 3.90% 3.86% 3.66% 3.53% 3.00% 2.97% 2.60% 2.60%

42 KYORIN Holdings, Inc IR TEL FAX URL Printed in Japan

キョーリン製薬ホールディングス株式会社およびその連結子会社 3 月 31 日に終了した各事業年度および 3 月 31 日現在 百万円 2009 年度 2010 年度 2011 年度 2012 年度 2013 売上高 99, , , , ,400 営業利

キョーリン製薬ホールディングス株式会社およびその連結子会社 3 月 31 日に終了した各事業年度および 3 月 31 日現在 百万円 2009 年度 2010 年度 2011 年度 2012 年度 2013 売上高 99, , , , ,400 営業利 アニュアルレポート 2014 2014 年 3 月期 キョーリン製薬ホールディングス株式会社 キョーリン製薬ホールディングス株式会社およびその連結子会社 3 月 31 日に終了した各事業年度および 3 月 31 日現在 百万円 2009 年度 2010 年度 2011 年度 2012 年度 2013 売上高 99,764 104,069 103,232 107,031 111,400 営業利益 13,261

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