Response of pre-and postoperative Glucose- Insulin-Kalium (GIK) loading in patients with valve replacement. Isao Sakashita*, Takeshi Ando*, Tetsunosuk

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1 Response of pre-and postoperative Glucose- Insulin-Kalium (GIK) loading in patients with valve replacement. Isao Sakashita*, Takeshi Ando*, Tetsunosuke Matsukawa* *Department and Ken-ichi Asano*. of Thoracic and Cardiovascular Surgery, Niigata University School of Medicine.

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6 of functional capacity and structure of anoxic myocardium. J. Clin. Invest., 47:403, ) Taylor, S.H.: Insulin and heart failure. Brit. Heart J., 33:329, ) Sodi -Pallares, D., Testelli, M.R., Fishleder, B.L., Sisteni, A., Medrano, G.A., Friendland, C. and DeMichell, A.: Effects of an intravenous infusion of a Potassium-Glucose-Insulin solution on the electrocardiographic signs of myocardial infarction. A preliminary clinical report. Amer. J. Cardiol., 9: 166, ) Scheuer, J.: Myocardial metabolism in cardiac hypoxia. Amer. J. Cardiol., 19:385, ) Owen, P., Thomas, M. and Opie, L.: Relative changes in free-fatty-acid and glucose utilization by ischemic myocardium after coronary-artery occlusion. Lancet, 1:1187, ) Weissler, A.M., Kruger, F.A., Baba, N., Scarpelli, D.G., Leighton, R.F. and Gallimore, J.K.: Role of anaerobic metabolism in the preservation 6) Krohn, B.C., Magison, 0., Lewis, R.R., Tsuji, H.K., Redington, J.V. and Kay, J.1-1.: Prevention of metabolic alkalosis following heart surgery. J. Thorac. Cardiovas. Surg., 56:748, ) Taylor, S.H., Sexton, C., Majid, P.A., Dykes, J.R.W., Ghosh, P. and Stoker, J.B.: Insulin secretion following myocardial infarction with particular respect to the pathogenesis of cardiogenic shock. Lancet, 1:7635, ) Sharma, S., Majid, P.A., Pakrashi, D.C., Dykes, J.R.W. and Taylor, S.H.: Insulin secretion in heart failure. Brit. Med. J., 2:396, ) Majid, P.A., Ghosh, P., Parashi, C., lonescu, M., Dykes, J.R.W. and Taylor, S.FI. : Insulin secretion after open-heart surgery with particular respect to pathogenesis of low cardiac output state Brit. Heart J., 33:6, ) Allison, S.P., Morley, C. J. and Burns-Cox, C. J.: Insulin, glucose, and potassium in the treatment of congestive heart failure. Brit. Med. J., 3:675, ) Gautam, H.P.: Improved cardiac performance with potassium, glucose, and insulin. Lancet, 1:1315, ) Braimbridge, M.V., Clement, A.J., Brown, A.H.,

7 1110 Sabar, E. and Mendel, D.: Triple starr valve replacement. Brit. Med. J., 3:683, ) Bradley, R.D. and Branthwaite, M. A.: Circulatory effects of potassium, glucose and insulin following open-heart suegery. Thorax, 25: 716, ) Moffitt, E. A., Rosever, J. W., Molnar, G. D. and McGoon, D. C.: The effect of glucose-insulin-potassium solution on ketosis following cardiac surgery. Anethesia and Analgesia, 50: 291, ) Moffitt, E. A., Molnar, G. D., Pluth, J. R., White, R. D. and McGoon, D. C.: Effects on metabolism and cardiac output of glucose-potassium solution, with and without insulin. Ann. Thorac. Surg., 15: 1, ) Pacifico, A. D., Digerness, S. and Kirklin, J. W: Regression of body compositional abnormalities of heart failure after intracardiac operation. Circ tia tion, 41:331, ) Briggs, A. P., Korchez, I., rorsy, E. A. and We_ ber, C. F.: Some changes in the composition of blood due to the infusion of insulin. J. Biol. Chem., 58: 721, ) Danielson, K. S., DeWeese, J. A. and Mahoney, E. B.: Evaluation of dextrose, insulin, and potassium on ventricular irritability in acute myocardial infarction. J. Thorac. Cardiovas. Surg., 60: 653, 1970.

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11) Kumar, R., et al.: Lancet, 1 : 90, 1973. 12) Baek, S. M., et al.: Ann. Surg., 177: 253, 1973. 13) Beak, S. M., et al.: Ann. Surg., 178 : 605, 1978. 14) Beak, S. M., et al.: Surgery, 77: 632, 1975.

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