Database Center for Life Science Online Service Matthias P. Mayer*, Toshifumi Tomoyasu* *, Bernd Bukau*, Institut fiir Biochemie and Molekularbiologie

Size: px
Start display at page:

Download "Database Center for Life Science Online Service Matthias P. Mayer*, Toshifumi Tomoyasu* *, Bernd Bukau*, Institut fiir Biochemie and Molekularbiologie"

Transcription

1 Matthias P. Mayer*, Toshifumi Tomoyasu* *, Bernd Bukau*, Institut fiir Biochemie and Molekularbiologie Universitat Freiburg Zentrum fur Molekulare Biologie (ZMBH) Universitat Heidelberg bukau@zmbh.uni-heidelberg.de Molecular mechanism of Hsp70 chaperones

2

3

4

5

6 1) Glover, J. R., Lindquist, S.: Cell, 94, (1998) 2) Goloubinoff, P., Mogk, A., Peres Ben Zvi, A., Tomoyasu, T., Bukau, B. : Proc. Natl. Acad. Sci. USA, 96, (1999) 3) Motohashi, K., Watanabe, Y., Yohda, M., Yoshida, M.: Proc. Natl. Acad. Sci. USA, 96, (1999) 4) Diamant, S., Peres Ben-Zvi, A., Bukau, B., Goloubinoff, P. J. Biol. Chem., 275, (2000) 5) Pratt, W. B.: Annu. Rev. Pharmacol. Toxicol., 37, (1997) 6) Wall, D., Zylicz, M., Georgopoulos, C. : J. Biol. Chem., 269, (1994)

7 7) Karzai, A. W., McMacken, R.: J. Biol. Chem., 271, (1996) 8) Pellecchia, M., Szyperski, T., Wall, D., Georgopoulos, C., Wuthrich, K. : J. Mol. Biol., 260, (1996) 9) Garner, J., Multhaup, G., Tomoyasu, T., McCarty, J. S., Rudiger, S., Schonfeld, H.-J., Schirra, C., Bujard, H., Bukau, B. EMBO J., 15, (1996) 10) Barouch, W., Prasad, K., Greene, L., Eisenberg, E. : Biochemistry, 36, (1997) 11) Laufen, T., Mayer, M. P., Beisel, C., Klostermeier, D., Reinstein, J., Bukau, B. : Proc. Natl. Acad. Sci. USA, 96, (1999) 12) Harrison, C. J., Hayer-Hartl, M., Di Liberto, M., Hartl, F.-U., Kuriyan, J.: Science, 276, (1997) 13) Zhu, X., Zhao, X., Burkholder, W. F., Gragerov, A., Ogata, C. M., Gottesman, M., Hendrickson, W. A.: Science, 272, (1996) 14) Schmid, D., Baici, A., Gehring, H., Christen, P. : Science, 263, (1994) 15) Hohfeld, J., Jentsch, S. : EMBO J., 16, (1997) 16) Sondermann, H., Scheufler, C., Scheider, C., Hohfeld, J., Hard, F.-U. & Moarefi, I.: Science, 291, (2001) 17) Takayama, S., Reed, J. C.: Nat Cell Biol, 3, E (2001) 18) Liiders, J., Demand, J., Hohfeld, J.: J. Biol. Chem., 275, (2000) 20) Ha, J.-H., Johnson, E. R., McKay, D. B., Sousa, M. C., Takeda, S., Wilbanks, S. M. : in Molecular Chaperones and Folding Catalysts. Regulation, Cellular Function and Mechanism (ed. Bukau, B.), pp , Harwood Academic Publishers, Amsterdam (1999) 19) Flaherty, K. M., Deluca-Flaherty, C., McKay, D. B. : Nature,346, (1990) 21) Liberek, K., Marszalek, J., Ang, D., Georgopoulos, C., Zylicz, M. : Proc. Natl. Acad. Sci. USA, 88, (1991) 22) Gassler, C. S., Wiederkehr, T., Brehmer, D., Bukau, B., Mayer, M. P. : J. Biol. Chem., 276, (2001) 23) Riidiger, S., Germeroth, L., Schneider-Mergener, J., Bukau, B.: EMBO J., 16, (1997) 24) Rudiger, S., Schneider-Mergener, J., Bukau, B. : EMBO J., 20,1-9(2001) 25) Misselwitz, B., Staeck, 0., Rapoport, T. A. : Mol. Cell., 2, (1998) 26) Mayer, M. P., Schroder, H., Rudiger, S., Paal, K., Laufen, T., Bukau, B. : Nature Struct. Biol., 7, (2000) 27) Pellecchia, M., Montgomery, D. L., Stevens, S. Y., Vander Kooi, C. W., Feng, H., Gierasch, L. M., Zuiderweg, E. R. P. : Nature Struct. Biol., 7, (2000) 28) Riidiger, S., Mayer, M. P., Schneider-Mergener, J., Bukau, B. : J. Mol. Biol., 304, (2000)

Teru Ogura, Tomoko Yamada-Inagawa, E-mail : ogura@gpo.kumamotou.ac.jp AAA family ATPases : ring-shaped chaperones which catalyze energy-dependent conformational changes of proteins 29) Braun, S.,

More information

表1.eps

表1.eps Vol.1 C ontents 1 2 cell-free EMBO J Proc. Natl. Acad. Sci. USA NatureEMBO J 3 RNA NatureEMBO J Nature EMBO J 4 5 HCV HCV HCV HCV RNA HCV in situ 6 7 8 Nat Struct Mol Biol J Biol Chem Nat Commun J Virol

More information

Various function and toxicity of iron Key words 1) Hentze, M. W. et al: Cell, 117, 285-297 (2004) 2) Ganz, T.: Blood, 102, 783-788 (2003) 3) Nemeth, E. et al.: Science, 306, 2090-2093 (2004) 4) Hentze,

More information

Kazumitsu Ueda, [Department of Applied Life Science, Kyoto University Graduate School of Agriculture, Kitashirakawa, Sakyo-ku, Kyoto 606-01, Japan] Molecular Mechanisms for Drug Transport by MDR1/P-glycoprotein

More information

Florigen in rice Key words Shojiro Tamaki, Ko Shimamoto E-mail : s-tamaki@bs.naist.jp, simamoto@bs.naist.jp URL : http://bsw3.naist.jp/simamoto/simaoto.html 1) Thomas, B., Vince-prue, D.: Photoperiodism

More information

tary adenylate cyclase activating polypeptide ; PA-

tary adenylate cyclase activating polypeptide ; PA- Conformation of a peptide ligand bound to its G-protein coupled receptor and its implication for ligand transportation tary adenylate cyclase activating polypeptide ; PA- molecular biology (ed. Rich,

More information

Spatio-temporal regulation of ERK1/2 MAP kinase 20) Murphy, L. 0., MacKeigan, J. P., Blenis, J.: Mol. Cell. Biol., 24, 144-153 (2004) 21) Harada, T., Morooka, T., Ogawa, S., Nishida, E.: Nature Cell

More information

untitled

untitled Fig.1 t O O N,N p n J J J J J t J J J J J J J J J J J t t J J J J J J J J J p Fig.2 p t Fig.3 Fig.4 synanti p Table1 Table2t Table2 synanti antisyn synanti synanti Fig.5 syn anti anti Fig.6 Table3 Table4

More information

Correlation between molecular evolution of P450s and evolution of plant secondary metabolism Masaharu Mizutani E-mail : mizutani@scl.kyoto-u.ac.jp URL : http://biofun.kuicr.kyoto-u.ac.jp/index-j.html 13)

More information

.i...j...[.X8-2

.i...j...[.X8-2 Vol. 8 No.2 Nov. 2007 1 2 4 12 20 37 45 54 56 62 1 2 3 4 5 7 6 8 9 10 11 13 12 15 14 17 16 19 18 21 20 Hatena 23 22 Oidiodendron Oidiodendron 25 24 Monosiga ovata Monosiga 27 26 Toxoplasma gondii 29 28

More information

drug development Toshimi Michigami, E-mail : michigami@mch.pref.osaka.jp Keiichi Ozono, E-mail : keioz@ped.med.osaka-u.ac.jp The progress in the research on vitamin D 1) McCollum, E. V. et al.:

More information

Kazumitsu Ueda, E-mail : uedak@kais.kyoto-u.ac.jp http : //cseika-1, kais.kyoto-u.ac.j p Molecular mechanism of multidrug transporter MDR I : ABC in host-defense machinery 32P-ATP 1) Chen, C., Chin,

More information

Novel chemical mediators in the resolution of inflammation Charles N. Serhan Key words E-mail : marita@nih.go.jp Charles N. Serhan Brigham & Women's Hospital/Harvard Medical School 1) Serhan, C. N.,

More information

Database Center for Life Science Online Service

Database Center for Life Science Online Service Database Center for Life Science Online Service Database Center for Life Science Online Service Database Center for Life Science Online Service Database Center for Life Science Online Service SMN (Survival

More information

Database Center for Life Science Online Service Signal transduction of growth factor mediated by heparin heparan sulfate

Database Center for Life Science Online Service Signal transduction of growth factor mediated by heparin heparan sulfate Signal transduction of growth factor mediated by heparin heparan sulfate 1) Zhu. X.. Komiya, H., Chirino, A.. Faham. S.. Fox, G. M., Arakawa, T., Hsu, B.T., Rees, D. C.: Science. 251, 90-93 (1991)

More information

The function and structure of NAD kinase: the key enzyme for biosynthesis of NADP (H) Database Center for Life Science Online Service Key words Shigey

The function and structure of NAD kinase: the key enzyme for biosynthesis of NADP (H) Database Center for Life Science Online Service Key words Shigey The function and structure of NAD kinase: the key enzyme for biosynthesis of NADP (H) Key words Shigeyuki Kawai, Chikako Fukuda, Kousaku Murata E-mail : kawais@kais.kyoto-u.ac.jp, chikakko@kais.kyotou.ac.jp,

More information

10中西_他.indd

10中西_他.indd Streptomyces mobaraensis N N N Sm b Sm N N Sm Sm Sm ' ' Sm Sm ak K k K bk k K Sm Sm a b S. mobaraensis a b a b Sm b b bb b b Sm Sm S. lividans ab Sm ab Sm ab ab ab ab SmSm S. lividansab S. lividans ab

More information

Database Center for Life Science Online Service Chiharu Ueguchi, Molecular mechanism and biological function of t

Database Center for Life Science Online Service Chiharu Ueguchi,   Molecular mechanism and biological function of t Chiharu Ueguchi, E-mail : cueguchi@agr.nagoya-u.ac.jp Molecular mechanism and biological function of the cytokinin signal tansduction pathway 1) Miller, C. 0., Skoog, F., von Saltza, M. H., Strong,

More information

Database Center for Life Science Online Service Structure and function of nitric oxide synthases

Database Center for Life Science Online Service Structure and function of nitric oxide synthases Structure and function of nitric oxide synthases 3) Furchgott, R. F., Zawadzki, J. V. : Nature, 288,373-376 (1980) 4) Palmer, R. M., Ferrige, A. G., Moncada, S.: Nature, 327,524-5260987) 5) Alderton,

More information

4) H. Takayama et al.: J. Med. Chem., 45, 1949 (2002). 5) H. Takayama et al.: J. Am. Chem. Soc., 112, 8635 (2000). 6) H. Takayama et al.: Tetrahedron Lett., 42, 2995 (2001). 9) M. Kitajima et al: Chem.

More information

Database Center for Life Science Online Service Discovery, analysis and chemical mechanism of protein splicing

Database Center for Life Science Online Service Discovery, analysis and chemical mechanism of protein splicing Discovery, analysis and chemical mechanism of protein splicing VMA1 VMA1 2) Anraku, Y.: Genes to Cells, 2, 359-367 (1997) 3) Perler, F. B.: Cell, 92,1-4 (1998) 4) Perler, F. B.: Trends Biochem.

More information

E-mail : tmatsumo@house.rbc.kyoto-u.ac.jp htm Spindle checkpoint : Cell cycle regulation by a signal emitted from kinetochores http://www.rbc.kyoto-u.ac.jp/radiation_system/m-index. 19) Yao, X., Abrieu,

More information

Review Column 1) Extavour, C. G., Akam, M. : Development, 130, 5869-5884 (2003) 2) Saitou, M. et al.: Philos. Trans. R. Soc. Lond. B. Biol. Sci., 358,1363-1370(2003) 3) Eddy, E. M. : Int. Rev.

More information

Database Center for Life Science Online Service Miho Shimizu, [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sap

Database Center for Life Science Online Service Miho Shimizu, [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sap Miho Shimizu, [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060, Japan] Molecular Basis of Triplet Repeat Diseases : Genetic Instabillity and Unusual DNA

More information

1) van Meer, G., Op den Kamp, J. A.: J. Cell. Biochem., 19, 193-2040982) 2) Gaffet, P., Bettache, N., Bienvenue, A.: Biochemistry, 34, 6762-6769(1995) 3) Sims, P. J., Wiedmer, T.: Thromb. Haemost., 86,

More information

Short Review E-mail : kuwata@cc.gifu-u.ac.jp Structural medicine and structure-based drug design for prion diseases 2) Anfinsen, C. B.: Harvey Lect., 61, 95-116 (1967) 3) Carrel, R. W., Lomas, D. A.

More information

Database Center for Life Science Online Service

Database Center for Life Science Online Service 図8SINEの SINEと3'末 親 と な って い るLINEの 系 統 関係 端 を共 有 して い るLINEは 赤 色 で 示 す, 報 告 さ れ て い るす べ て のLINEは11の ら れ る.そ れ ぞ れ のLINEの グル ー プ に分 け あ い だ にお い て 水 平 的 な交 流 が な い と仮 定 す る と,こ の11に 分 け られ る こ のLINE え

More information

Review Database Center for Life Science Online Service Masanori Mishima, p Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

Review Database Center for Life Science Online Service Masanori Mishima, p Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge Review Masanori Mishima, p Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge E-mail : m.mishima @gurdon.cam.ac.uk http://www.gurdon.cam.ac.uk/groups/mishima.html Cytokinesis :

More information

D., Nicola, N. A., Hilton, D. J.: Nature, 387, 917-921 (1997) 12) Alexander, W. S. : Nat. Rev. Immunol., 2,410-416 (2002) 13) Chung, C. D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., Shuai, K. : Science,

More information

2

2 1999 No. 5 CHAPERONE NEWSLETTER CONTENTS 2 3 4 JEM JEM JEM, SEC, SCJ JEM JEM SCJ jem, scj 5 in vitro S. cerevisiae 6 K 7 in vitro Cell Mol. Cell in vitro 8 9 E. coli E. coli 10 in vitro ssc - b 11 in vivo

More information

Makoto Onoda, Department of Anatomy and Cell Biology, Georgetown University School of Medicine, 3900 Reservoir Road, N. W., Washington, D. C. 20007, USA Regulation Mechanism of Spermatogenesis : Cell-to-cell

More information

本文/YA9255F

本文/YA9255F pp. ATP ε ATP ATP ATP ε Bacillus PS ATP ATP H H µ H ATP ATP ADP µ H ATP FoF -ATP FoF -ATP µ H H ADP ATP H Na On the regulatory role of the epsilon subunit in ATP synthase Yasuyuki Kato-Yamada Department

More information

Review Yoshihiro Yoneda, Soo Jae Lee, E-mail : yyoneda@anat3.med.osaka-u. ac.jp http: //www.anat3.med.osaka-u.ac.jp/ Molecular basis of importin g revealed by crystal structures 2) Yoneda, Y. : Genes

More information

Generation of neural cells from embryonic stem cells Database Center for Life Science Online Service Takuya Yohei Okada Takahito Hideyuki Shimazaki Yo

Generation of neural cells from embryonic stem cells Database Center for Life Science Online Service Takuya Yohei Okada Takahito Hideyuki Shimazaki Yo Generation of neural cells from embryonic stem cells Takuya Yohei Okada Takahito Hideyuki Shimazaki Yoshizaki* Okano McLean Hospital/Harvard University Udall Parkinson's Disease Research Center of Excellence

More information

Review Fumio Imamoto1, Takefumi Sone1, Kazuhide Yahata1, Yukari Sasaki1, Masatoshi Takagi2, Kazuhiro Maeshima2, Naoko 25) Dong, W. K. et al.: Gene, 91, 217-223 (1990) 26) Masatsugu, T. et al.:

More information

[Nippon Nogeikagaku Kaishi

[Nippon Nogeikagaku Kaishi [ Nippon Nageikagaku Kaishi Vol. 72, No. 11, pp. 1333 `1344, 1998 l Key words: methylotrophic yeast; gene expres sion; C1-metabolism; peroxisome Cellular Functions of the Methylotrophic Yeast: Their Molecular

More information

Biology of spermatogenesis and spermatozoa in mammals. Biophys. Biochem. Cytol. Arch. Biochem. Biophys. Anat. Rec. Biol. Reprod. Mol. Hum. Reprod. Biol. Reprod. Reprod. Biol. Endocrinol. Aust. J. Zool.

More information

Database Center for Life Science Online Service

Database Center for Life Science Online Service 1) Epps, H. M., Gale, E. F.: Biochem. J., 36, 619-623 (1942) 2) Monod, J.: Recherches sur la croissance des cultures bacteriennes, Ph. D. thesis. Her mann,paris (1942) 3) Magasanik, B.: Cold Spring Harbor

More information

宿 主 特 異 性 を決 定 す る た め に非 常 に大 き な 役 割 を も った 割 を 演 じ る こ と に な る.ま 物 質 で あ る こ とは 間 違 い な い.ま た,Nod る菌 体 外 多 糖 の生 成 が菌 の 感 染 に 関与 して い る こ と も知 factorは マ メ科 植 物 根 細 胞 の 根 粒 形成 に 関 す る 遺 伝 子(nodulin gene)を

More information

Stress-responsive MAP kinases 15) Lu, H. T., Yang, D. D., Wysk, M., Gatti, E., Mellman, I., Davis, R. J., Flavell, R. A. : EMBO J., 18,1845-1857 (1999) 16) Lu, B., Yu, H., Chow, C., Li, B., Zheng,

More information

Vol.53 No. 11 (2008) 1327

Vol.53 No. 11 (2008) 1327 Molecules that regulate morphology of the plasma membrane Shiro Suetsugu, Kazunori Takano E-mail : suetsugu@iam.u-tokyo.ac.jp 1326 Vol.53 No. 11 (2008) Vol.53 No. 11 (2008) 1327 1328 Vol.53 No. 11 (2008)

More information

Database Center for Life Science Online Service Natronobacterium pharaonis Crystal structure of phoborhodopsin : Mechanisms of color tuning and signal

Database Center for Life Science Online Service Natronobacterium pharaonis Crystal structure of phoborhodopsin : Mechanisms of color tuning and signal Natronobacterium pharaonis Crystal structure of phoborhodopsin : Mechanisms of color tuning and signal transduction Needleman, R., Lanyi, J. K. : Science, 269,73-75 (1995) 3) Bogomolni, R. A., Stoeckenius,

More information

たんぱく3000web.indd

たんぱく3000web.indd 1 2 4 5 3000 6 8 3000 10 10 11 11 12 12 13 13 14 18 19 20 21 Atg 22 23 24 21 X 143000 3000 19 3000 20 25 X 26 27 28 1 20 DNA mrna DNA RNA mrna 3000 DNAmRNARNA SPring-8X Artsimovitch, I. et al., Cell 117,

More information

本文/YA7261E

本文/YA7261E J. Cell Biol.,,. Segev, N.Curr. Opin. Cell Biol.,,. Lafont, F., Lecat, S., Verkade, P., & Simons, K.J. Cell Biol.,,. Mostov, K.E., Verges, M., & Altschuler, Y.Curr. Opin. Cell Biol.,,. Sato, T., Mushiake,

More information

酵母 にお ける性 フ ェ ロモ ンの シ グナ ル 伝達 多 細 胞 生 物 に お け る 細胞 の機 能 は,ホ 土 屋 英 子 1 福 井 作 蔵 1,2 ル モ ンな ど 様 々な 情 報 分 子 に よ る 調 節 を 受 け て い る.細 胞 表 面 の レセ プ タ ー で 受 容 され た 外 来 情 報 は 細胞 膜 を介 し,ご え られ,細 宮 川 都 吉 1 く限 られ

More information

Database Center for Life Science Online Service Enzyme Research, The University of Tokushima, Kuramoto-cho, Tokushima 770, Japan] Clathrin : Its Struc

Database Center for Life Science Online Service Enzyme Research, The University of Tokushima, Kuramoto-cho, Tokushima 770, Japan] Clathrin : Its Struc Enzyme Research, The University of Tokushima, Kuramoto-cho, Tokushima 770, Japan] Clathrin : Its Structure and Role in Intracellular Transport 3) c ã T : Œ» 㻚w, J Š 10, 100-123 (1987) 4 zpfeffer,

More information

ü β 93

ü β 93 Amyloid Fibril Formation and Protein Science Yuji GOTO Institute for Protein Research, Osaka University E-mail: ygoto@protein.osaka-u.ac.jp Abstract: Amyloid fibrils have been a critical subject in recent

More information

1) Y. Hatefi: Annu. Rev. Biochem., 54, 1015 (1985). 2) H. Weiss, T. Friedrich, G. Hofhaus & D. Preis: Eur. 4) M. Yamaguchi & Y. Hatefi: Biochemistry, 32, 1935 (1993). 5) K. Leonard, H. Haiker & H. Weiss:

More information

2007050781......_.L.O...z.W

2007050781......_.L.O...z.W a s d f g a s d f g h j k l 0 in vitro in vivo in vitro in vivo in vivo in vivo in vitro Metabolism Metabolism Endocr Endocr Endocrinol Ann NYA cad Sci J clin Endocr Metab

More information

Minamiooya, Machida, Tokyo 194, Japan] RNA World, A Key Step in the Origin of Life : Inspection from the View Point of Biological Evolution 1) Crick, F. H. C.: Sym. Soc. Exp. Biol., 12, 548-555

More information

Database Center for Life Science Online Service

Database Center for Life Science Online Service 1) Bittner, J. J.: Science, 84, 162 (1936) 13) Michalides, R., van Ooyen, A., Nusse, R.: Curr. Top. Microbiol. Immunol., 106, 57-74 (1983) 2 z Yamamoto, K. R.: Ann. Rev. Genn., 19, 209-252 (1985) 3) Evans,

More information

Database Center for Life Science Online Service (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*,

Database Center for Life Science Online Service (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*, (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*, E mail : takaabe@mail.cc.tohoku.ac.jp Taro Tokui, Molecular identification of organic anion transporter

More information

会報35号表紙.pdf

会報35号表紙.pdf 35 No. (2017 1 ) RNA 2017 2017 TV 365 365 chunky 26 RNA 2017 Congratulations26 30-1 - RNA 2017-2 - - 3 - - 4 - - 5 - - 6 - 2016 8 31 9 2 RNA 2016 1 RNA RNA RNA RNA RNA 1-7 - RNA RNA 3 3 7 31 RNA ncrna

More information

Database Center for Life Science Online Service [Department of Molecular Physiology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome,

Database Center for Life Science Online Service [Department of Molecular Physiology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome, [Department of Molecular Physiology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome, Bunkyo-ku, Tokyo 113, Japan] [Graduate School of Agricultral Bioscien- ces, The University of Tokyo,

More information

Database Center for Life Science Online Service Masami Horikoshi, Ryosuke Himukai, Takashi Kuzuhara,

Database Center for Life Science Online Service Masami Horikoshi, Ryosuke Himukai, Takashi Kuzuhara, Masami Horikoshi, Ryosuke Himukai, Takashi Kuzuhara, E-mail : horikosh@iam.u-tokyo.ac.jp http://www.iam.u-tokyo.ac.jp/homasami/ 1) Jacob, F., Monod, J. : J. Mol. Biol., 3, 318-356 (1961) 2) Ptashne,

More information

Database Center for Life Science Online Service

Database Center for Life Science Online Service 2) Shin, S. I., Fredman, V. H., Risser, P., Pol lack,r.: Proc. Natl. Acad. Sci. USA, 72, 4435-4439 (1975) 3) Marquardt, H., Todaro, G. J.: J. Biol. Chem., 256, 6859-6865 (1981) 4) Dicker, P., Pohjanpelto,

More information

Database Center for Life Science Online Service archlaboratories, 4-1-1 Miyazaki, Miyamae-ku, Kawasaki-shi, Kanagawa 213, Japan] Developmental Genetics of Caenorhabditis elegans Database Center for

More information

RX501NC_LTE Mobile Router取説.indb

RX501NC_LTE Mobile Router取説.indb 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 1 2 3 4 5 6 7 8 19 20 21 22 1 1 23 1 24 25 1 1 26 A 1 B C 27 D 1 E F 28 1 29 1 A A 30 31 2 A B C D E F 32 G 2 H A B C D 33 E 2 F 34 A B C D 2 E 35 2 A B C D 36

More information

本文/AY380J

本文/AY380J MHC-II II MHC-II MHC- II CD T T TCR T T MHC-II MHC-II T MHC-II MHC-II MHC-II MHC-II Ii Ii-MHC-II MHC-II antigen processing compartment MIIC Regulation of cell surface expression of MHC-II in dendritic

More information

Database Center for Life Science Online Service Natuo Komoto, jp Silkworm mutants

Database Center for Life Science Online Service Natuo Komoto,   jp   Silkworm mutants Natuo Komoto, E-mail : natuo@affrc.go. jp http://cse.nias.affrc.go.jp/natuo/index.htm Silkworm mutants whose deficiency of epidermal orate granules causes translucent larval skin phenotypes 図3 カイ コ幼 虫

More information

Bio-No.57/3....

Bio-No.57/3.... 2004. MAR. 3No.57 http://www.wako-chem.co.jp C O N T E N T S 2 Wako Bio Window No.57 MAR.2004 l l l l wako wako l l mmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmm Wako Bio Window No.57 MAR.2004 3 4 Wako Bio Window

More information

% 32.3 DI DI

% 32.3 DI DI 2011 7 9 28.1 41.4 30.5 35.8 31.9% 32.3 DI 18.2 2.4 8.1 3.5 DI 9.4 32.2 0.0 25.9 2008 1 3 2 3 34.8 65.2 46.753.8 1 2 8.82.9 43.1 10 3 DI 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

More information

2 DI 28 7 1 37 28 4 18 27 11 21 5 2 26 4 5 1 15 2 25 3 35 4 17 7 5 48 76 31 47 17 2 92 12 2 2 4 6 8 1 12 1 2 4 1 12 13 18 19 3 42 57 57 1 2 3 4 5 6 1 1 1 3 4 4 5 5 5.5 1 1.5 2 2.5 3 3.5 4 4.5 5

More information

3 DI 29 7 1 5 6 575 11 751, 13 1,1,25 6 1,251,5 2 1,51,75 1,752, 1 2,2,25 2,252,5 2,53, 3,3,5 3,5 5 1 15 2 25 3 5 6 575 12 751, 21 1,1,25 27 1,251,5 9 1,51,75 1,752, 1 2,2,25 2 2,252,5 2,53, 2 3,3,5

More information

31, 21% 24, 17% 8, 5% 23, 16% 24, 16% 91, 62% 19, 13% 39, 27% 33, 23% 73 48 57 51 31 1 9 13.0% 7.4% 5.3% 12.5% 17.1% 13.2% 17.9% 4.5% 36.4% 56.5% 40.7% 36.8% 50.0% 67.1% 56.3% 65.8% 75.0% 26.0% 37.0%

More information

37 27.0% 26 19.0% 74 54.0% 9 6.4% 13 9.2% 28 19.9% 26 18.4% 37 26.2%. 24 17.0% 99 69 75 59 39 1 6 4.5% 1.4% 7.7% 2.9% 25.0% 17.9% 20.8% 50.0% 41.7% 47.0% 51.4% 54.3% 61.5% 57.1% 55.6% 42.4% 50.0% 58.3%

More information

本文/YA9121A

本文/YA9121A pp. CD CDHA HA CD HABD NMR HABD C HA ordered O -state HA partially disordered PD -state PD-state CD HA HA CD CD A Two-state equilibrium of hyaluronan-binding domain is crucial for CD -mediated cell rolling

More information

VOL33NO.3/2010 A B A B p-erk1/2 Time (min) 0 1 2 5 10 15 30 60 90 120 Erk1/2 Time (min) 0 1 2 5 10 15 30 60 90 120 p-vasp VASP C D enos/gapdh x-fold vs sham 2.0 1.5 1.0 0.5 * 0 ANP (-) (+) (-)

More information

取扱説明書

取扱説明書 ED-601 ED-501 ED-401 2 3 4 23 14 5 6 18 10 7 1 2 6 3 4 8 9 16 16 16 12 1 2 18 10 2 1 5 12 11 1 2 1 2 12 1 2 13 16 14 3 2 4 1 1 2 16 3 4 18 15 1 2 16 2 3 1 1 2 3 18 17 18 22 19 D A C 20 A B 22 B C D 22

More information

あまり関係ないことまで述べられていないか?( 混乱の元になるので良くない ) 引用の仕方は首尾一貫しているか?( 複数入り混じるのは良くないと思う ) 悪い例 : 先行研究においては~という結果が得られた(Tsugame et al., 2014) 一方 Tsugamo らは~という結果も得ている

あまり関係ないことまで述べられていないか?( 混乱の元になるので良くない ) 引用の仕方は首尾一貫しているか?( 複数入り混じるのは良くないと思う ) 悪い例 : 先行研究においては~という結果が得られた(Tsugame et al., 2014) 一方 Tsugamo らは~という結果も得ている 論文についての覚え書き 2016 年 9 月 14 日改訂 津釜大侑 研究を進めていく上で論文を読むのは最も基本的で重要な作業です 論文を読む上で気を 付けると良いと思われることについて以下に挙げます 論文の種類 Research article 実験解析の結果を載せる 論文というと普通これを指す ゼミではこれを扱います Short communication 量は多くないが重要性が高いデータを迅速に公表するためのもの

More information

- 111 -

- 111 - - 110 - - 111 - - 112 - - 113 - - 114 - - 115 - - 116 - - 117 - - 118 - - 119 - - 120 - - 121 - - 122 - - 123 - - 124 - - 125 - - 126 - - 127 - - 128 - - 129 - - 130 - - 131 - - 132 - - 133 - - 134 - -

More information

2 3 2

2 3 2 1 2 3 2 ha ha ha 3 4 ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) 5 5 ( ) ( ) 3 ( ) ( ),,, 5 6 7 ( ) ( ) ( ) ( ) ( ) ( ) 6 36.3% ( ) 8 ( ) ( ) ( ) ( ) ( ) ( ) 3 5 ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( )

More information

- 8 -. 1 (1) (2) (3) (4) (5) (6) (7) (8)

- 8 -. 1 (1) (2) (3) (4) (5) (6) (7) (8) - 7 - (1) (2).. ha 43 ( (1) ( ) (2).. 18 11 30 43 (1).. (2).. 0.5. () () A) B) C) - 8 -. 1 (1) (2) (3) (4) (5) (6) (7) (8) (1) (2) 43-9 - - 10 - (1).. 43.. 43... 43 - 11 - (2) (1).. A B A A B A - 12 -.

More information

untitled

untitled 1,985ha 41.5 2,799ha 58.5 4,784ha 100.0 3 14,210 0 0.0 27 57,590 37,140 64.5 3 1,800 930 51.7 6 1,150 1,150 31.0 39 77,310 39,220 50.7 34 8-3 34 8-4 52 1-6 52 2-3 53 1-6 56 1-2 56 1 18 12 17 30 50

More information

9 5 1 9 30 17 10 1 21 30 18 10 1 22 30 18 10 1 20 30 16 10 1 20 30 31 16 60 9 63 9 65 9 3 14 1 2 3 4 19 10 1 5,600 20,000 21,500 10 10 1,540 1,540 950 950 178 15 5,329 19 1,900 200 19 12 1 200 3,429

More information

100 26331 26331 7,082ha(6.9% 9,027ha(8.8) 903ha(0.9%) 1,2292.5% 5,45711.2% 2,916(6.0%) 80,622ha79.0 4,507ha4.4% 18,277(37.4) 2949 (42.9% ( ) !! 1008940 (03)3581-4111 http://www.mof.go.jp/ 0608579

More information

300 10

300 10 300 10 16 1695 4 2 44 7 3 1 2 2 1869 11 192210 506.75ha 3 (1594) (1596) 16 17 7 1630 2 14 1637 16 17 4 1664 5 6 1678 6 1678 6 3 8 16954 8 (1758) 7 (1770) 17 2 (1745) 2 (1765) 4 11 11 10 12 1 12 12 12 2

More information

untitled

untitled 2 23 3 28 10 12 1 2 3 18 6 1 1 2 9 9 5 22 1 22 10 2 100 9 9 9 1 11 2,300 22 10 8 90 5 80 90 100 5,000 100 90 5 90 8 90 13 1 22 20 / 14 / 10 / 1 13 80 8 80 80 7 8 13 80 7 90 2 200 300 3 4 10 1 1 90 5 90

More information

第1 予算編成の基本的な考え方

第1 予算編成の基本的な考え方 - 1 - - 2 - - 3 - - 4 - - 5 - - 6 - - 7 - - 8 - ) () (

More information

0

0 ... 1... 2... 3... 5... 10... 13... 15... 19... 22... 24... 26... 27 0 0 1 2 H13 12 3 4 H21 15.7 5 29.8 10 1 6 4 1 10 1 50,284 48,834 46,185 41,056 33,892 26,726 7 8 9 1012 10 11 12 136ha 80.7ha 13 14

More information

0.表紙

0.表紙 60 10 11 11 11,600 36,500 10,500 7,900 +1,500+1,500+9,000+18,0003,70041,600 12 3.84ha 3,100 3,100 4,400 2,785 5,000 50 70 3,500 3,500 2,600 30 2,600 45 3,375 40 4,500 20 2,000 12 1,500 12 2,300 7,500

More information

1 4 8 19 65 87 108 132 142 156 - 1 - - 2 - - 3 - - 4 - - 5 - - 6 - - 7 - - 8 - - 9 - - 10 - - 11 - - 12 - - 13 - - 14 - - 15 - - 16 - - 17 - - 18 - 30-19 - - 20 - ( ) - 21 - - 22 - - 23 - - 24 -

More information

-2-

-2- -1- -2- -3-24 32ha 13-4- 30-5- -6- -7- 100-8- 20 20 100-9- 100-10- 100 100-11- -12-30 -13- 10-14- 52 71 59-15- 30-16- -17- -18- 31 31-19- -20- 47 52 71 29 41 59 306 88 348-21- -22- -23- -24- 12-25- 1,300

More information

総務委員会会議録

総務委員会会議録 29 28 29 29 () 121 1 111 11928 3 () () () () 11928 3 1,320 32,7897,000 () 1 23725,000 9 1,320 313 2,7897,000 2 2 2 5.5 16 15200 31 29 2931 3110 21 21 5 6 8,2195,000 2134,1097,000 1,320 32,7897,000 31 ()

More information

14 12 ( 17 4 2 ) 2004

14 12 ( 17 4 2 ) 2004 14 12 ( 17 4 2 ) 2004 1 4,700 1980 1,757 1,150 25,000ha 6,000ha 10 10 10 2 1981 56 90 4,700 1980 1,757 1,150 2003 187,614 96,940 51.7 17 102,128 54.7 2004 545 76 14 2004 4 13 49.1 1981 84,638 38,272 17,570

More information

,

, 34 29 5 29 6 29 7 30 28 26 1 1-71 - , - 72 - 27 3 1, - 73 - 5811 5821 5822 5831 58 2 5841 5851 5861 5862 5863 5864 5892 5896 5897 5898 5891 5895 7711 622 6311 6312 6314 6324 6032 6033 7611 7621 7623 7624

More information

Molecular bases for plant circadian clock and flowering : How does the quintet tell the time? Cell, 101, 319-329(2000) 8) Schultz, T. F., Kiyosue, T., Yanovsky, M., Wada, M., Kay, S. 9) A. : Plant

More information

図1 A:融 試 験 管 内 受 精 と胚 様 体 発 育 お よび 植 物 体 再 生(ト ウ モ ロ コ シ) 合 前 の卵 細 胞(E)と 精 細 胞(S).バ ー=50μm, B:第1回 の 分 裂(融 合42時 間 後).バ ー=50μm, C:多 細 胞体(5日 後).バ ー=100μm, D:分 極 した 多 細 胞 体.一 方 の 極 に 細 胞 層 が,も う一 方 に液 胞 の

More information

肺癌第50巻第4号

肺癌第50巻第4号 1 Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan; 2 Department of Thoracic Surgery, Aichi Cancer Center, Japan;

More information

Short Review Database Center for Life Science Online Service bicoid oskar mrna. gurken mrna bicoid mrna Tamaki Yano,

Short Review Database Center for Life Science Online Service bicoid oskar mrna. gurken mrna bicoid mrna Tamaki Yano, Short Review bicoid oskar. gurken bicoid Tamaki Yano, E-mail : tyanoc@mail.pharm.tohoku.ac.jp Maternal RNA localization and RNP-complex, essential for the polarization of the oocyte in Drosophila hunchback

More information

色覚(初組4).pm

色覚(初組4).pm 733 3 1 520 1 8 4 0.2500 1 30012 1 AB 3 22 3 1 2 http://www.nig.ac.jp/labs/devgen/mou.html 734 1.1 360nm 830nm 380nm 780nm 540nm 580nm 660nm 540nm 660nm Log relative corneal sensitivity 0 1 2 400 500 600

More information

2007 Vol.56 No.6 総説 丸山浩樹

2007 Vol.56 No.6 総説 丸山浩樹 Reprinted from RADIOISOTOPES, Vol.56,.6 June 2007 Japan Radioisotope Association http : //www.jrias.or.jp/ α β α β ε m z α µ µ α m z m z µ µ Curr. Opin. Biotechnol J. Proteome Res Rapid Commun. Mass

More information

日経テレコン料金表(2016年4月)

日経テレコン料金表(2016年4月) 1 2 3 4 8,000 15,000 22,000 29,000 5 6 7 8 36,000 42,000 48,000 54,000 9 10 20 30 60,000 66,000 126,000 166,000 50 100 246,000 396,000 1 25 8,000 7,000 620 2150 6,000 4,000 51100 101200 3,000 1,000 201

More information