Study on Patch Test Reagent for Titanium NAKAJIMA Koki Fixed Prosthodontics, Department of Restorative Sciences, Division of Oral Health Sciences, Gra
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1 Study on Patch Test Reagent for Titanium NAKAJIMA Koki Fixed Prosthodontics, Department of Restorative Sciences, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University (Chief and Director : Prof. MIURA Hiroyuki) Recently, allergy to titanium has been reported. However, the patch test reagent for titanium is not standardized yet. The form and density of the patch test reagent for titanium was changed and examined in a group of normal subjects and a group with skin disease. The following conclusions were obtained. 1. A reagent which was composed of pure titanium powder and vaseline was not preferable because its form was a stimulant. 2. If the form of the titanium powder was not sharp even though it was not spherical, it did not cause a stimulated reaction. 3. It is suggested that TiCl4 0.1% is preferable as a patch test reagent for titanium.
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3 94口 病誌 平 成19年6月 表1健 常 者 群 のPTの 図1各 1)健 常 者 群 の 酸 化 チ タ ン GDTi;50,30%とNanoTek PT試 間 と,NanoTek の4つ 行 い,各 チ タ ンPT試 Ti;50,30%の4つ の Ti;50,30%とTiO2;50,30% 間 に お い てKruskal-Wallisの 3)有 常 者 群 の 塩 化 チ タ ン 検定 を 1)健 金 属 粉 の 形 状 を 確 認 し た 走 査 電 子 顕 微 鏡 画 像 を 図1A Cに 符 号 付 き順 位 検 定 を 行 っ た はWilcoxonの 検 定 を 行 い,各 示 す こ れ を み る とGDTiは る NanoTek Tiは 直 径20μmの で き た TiO2はNanoTek 回転 切 削 器 具 に よ っ て 削 ら れ た 不 定 形 な 削 片 で あ り,鋭 問 に お い てWilcox- 病 者 群 の 塩 化 チ タ ン TiC14;0.2,0.1,0.05%の3つ 反 応 が 認 め ら れ た が,NanoTek は 全 く反 応 を 認 め な か っ た 群 間 で 有 意 差 が あ る場 合 病 者 群 の 酸 化 チ タ ン Friedmanの 示 す GDTi;50,30% Ti;50,30%とTiO2;50,30%,TiCl4;0.2,0.1%で 間 にお い 符 号 付 き順 位 検 定 を行 っ た 4)有 結 果 を 表1に 常 者群 健 常 者 群 のPTの 検 定 を 行 い,各 TiO2;30,10%の2つ onの 果 とTiC14;1,0.5%に TiCl4;1,0.5,0.2,0.1%の4つ に はWilcoxonの III.結 1.PT 群 間 で 有 意 差 が あ る 場 合 に はMalm-Whitney てFriedmanの の電 顕 像 の 検 定 を行 った 2)健 結果 Tiの 認 め ら れ な い が,GDTiの 間 におい て 利 な形 状 を呈 して い 球 状 で あ る こ とが 確 認 よ う に均 一 な球 状 とは よ う な鋭 利 な形 状 は確 認 で き な か っ た ま た 粉 末 の 大 き さ はNanoTek Tiよ り も小 さ い こ とが確 認 で き た 群 間 で 有 意 差 が あ る場 合 に 2)有 符 号 付 き順 位 検 定 を行 っ た 病 者群 有 病 者 群A,Bの は1名(0.37%)の (8) 結 果 を 表2に 示 す TiO2;30,10% み 疑 陽 性 反 応 と な っ た が,そ の他 は
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7 2) Fleischmann, P.: Zur Frage der Gefð rlichkeit kleinster QueckSilbermengen. Dt. Med. Wschr. 54 : , ) Fischer, A. A.: The role of patch testing, Contact Dermatitis. 3rd ed., Philadelphia, Lea & Febiger, ) Fregert, S. and Bandmann, H-J.: Test technique, Patch Testing. 1975, Springer-Verlag, ) Lalor, P. A.: Sensitivity to titanium. J-Bone-JT- Surg-Ser-B 73 : 25-28, ) Peters, M. S.: Pacemaker contact sensitivity. Contact Dermatitis 11: , ) Abdallah, H. I.: Pacemaker contact sensitivity: Clinical recognition and management. Ann. Thorac. Surg. 57: , ) Elves, M. W.: Incidence of metal sensitivity in patients with total joint replacements. British Medical Journal 4: , ) Macf arlane, A. W., Curley, R. K., Graham, R. M., Lewis-Jones, M. S. and King, C. M.: Delayed patch test reactions at day 7 and 9. Contact Dermatitis 20: , ) Fisher, T. and Rystedt, I.: A case of contact sensitivity to aluminum. Contact Dermatitis 8: 343, ) Vanneste, D., Martin, P. and Lachapelle, J. M.: Comparative study of the density of particles in suspensions for patch testing. Contact Dermatitis 6 : , ) Condie, M. W. and Adams, R. M.: Influence of oral prednisone on patch test reactions to rhus antigen. Arch. Dermatol. 107: , ) Sukanto, H., Nater, J. P. and Bleumink, E.: Influence of topically applied corticosteroids on patch test reactions. Contact Dermatitis 7: , 1981.
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